WO2015184380A8 - Snake venom for use in the treatment prior to a surgical procedure in the brain - Google Patents

Snake venom for use in the treatment prior to a surgical procedure in the brain Download PDF

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Publication number
WO2015184380A8
WO2015184380A8 PCT/US2015/033365 US2015033365W WO2015184380A8 WO 2015184380 A8 WO2015184380 A8 WO 2015184380A8 US 2015033365 W US2015033365 W US 2015033365W WO 2015184380 A8 WO2015184380 A8 WO 2015184380A8
Authority
WO
WIPO (PCT)
Prior art keywords
brain
injury
venom
treatment
snake venom
Prior art date
Application number
PCT/US2015/033365
Other languages
French (fr)
Other versions
WO2015184380A1 (en
Inventor
John H. ZHANG
Cherine KIM
Prativa SHERCHAN
Paul Krafft
Devin MCBRIDE
Tim LEKIC
Original Assignee
Loma Linda University
Loma Linda University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loma Linda University, Loma Linda University Medical Center filed Critical Loma Linda University
Publication of WO2015184380A1 publication Critical patent/WO2015184380A1/en
Publication of WO2015184380A8 publication Critical patent/WO2015184380A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A treatment for reducing brain or other injury that can be used before, during, or after a surgical treatment or other injury to the brain to decrease or prevent subsequent damage. Injury to the brain during surgery or from other trauma can create elevations in brain edema and blood-brain barrier disruption thereby decreasing neurological recovery and patient outcomes. Treatment of the brain with venom, including snake venom, prior to or after injury can reduce the bleeding, swelling, and/or inflammation that results from the trauma. These pre-conditioning and/or rapid-conditioning treatments of the brain with venom can reduce brain edema and blood-brain barrier disruption and improve patient outcomes.
PCT/US2015/033365 2014-05-30 2015-05-29 Snake venom for use in the treatment prior to a surgical procedure in the bran WO2015184380A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462005871P 2014-05-30 2014-05-30
US62/005,871 2014-05-30

Publications (2)

Publication Number Publication Date
WO2015184380A1 WO2015184380A1 (en) 2015-12-03
WO2015184380A8 true WO2015184380A8 (en) 2017-01-26

Family

ID=53762278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/033365 WO2015184380A1 (en) 2014-05-30 2015-05-29 Snake venom for use in the treatment prior to a surgical procedure in the bran

Country Status (1)

Country Link
WO (1) WO2015184380A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164196A (en) * 1987-05-19 1992-11-17 Ventech Research, Inc. Crotoxin complex as cytotoxic agent
US7208150B1 (en) * 1999-07-14 2007-04-24 S.I.S. Shulov Institute For Science Ltd. Analgesic from snake venom
AU2008341008A1 (en) * 2007-12-20 2009-07-02 The University Of Queensland Haemostasis- modulating compositions and uses therefor

Also Published As

Publication number Publication date
WO2015184380A1 (en) 2015-12-03

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