WO2015184249A3 - Sle and sle-related disease-associated risk markers and uses thereof - Google Patents

Sle and sle-related disease-associated risk markers and uses thereof Download PDF

Info

Publication number
WO2015184249A3
WO2015184249A3 PCT/US2015/033161 US2015033161W WO2015184249A3 WO 2015184249 A3 WO2015184249 A3 WO 2015184249A3 US 2015033161 W US2015033161 W US 2015033161W WO 2015184249 A3 WO2015184249 A3 WO 2015184249A3
Authority
WO
WIPO (PCT)
Prior art keywords
sle
related disease
risk markers
subjects
associated risk
Prior art date
Application number
PCT/US2015/033161
Other languages
French (fr)
Other versions
WO2015184249A2 (en
Inventor
Sergey Kozyrev
Göran Andersson
Helene HANSSON-HAMLIN
Kerstin Lindblad-Toh
Maria WILBE
Original Assignee
The Broad Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Broad Institute, Inc. filed Critical The Broad Institute, Inc.
Publication of WO2015184249A2 publication Critical patent/WO2015184249A2/en
Publication of WO2015184249A3 publication Critical patent/WO2015184249A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing systemic lupus erythematosus (SLE) or an SLE-related immune-mediated rheumatic disorder, such as IMRD or SRMA, or having undiagnosed SLE or an SLE-related immune-mediated rheumatic disorder, such as IMRD or SRMA. These subjects are identified based on the presence of germ-line risk markers.
PCT/US2015/033161 2014-05-30 2015-05-29 Sle and sle-related disease-associated risk markers and uses thereof WO2015184249A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462005828P 2014-05-30 2014-05-30
US62/005,828 2014-05-30

Publications (2)

Publication Number Publication Date
WO2015184249A2 WO2015184249A2 (en) 2015-12-03
WO2015184249A3 true WO2015184249A3 (en) 2016-01-28

Family

ID=54700068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/033161 WO2015184249A2 (en) 2014-05-30 2015-05-29 Sle and sle-related disease-associated risk markers and uses thereof

Country Status (1)

Country Link
WO (1) WO2015184249A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518885A (en) * 2020-04-22 2020-08-11 深圳市福田区风湿病专科医院 Method for detecting mutation sites of systemic lupus erythematosus genes
US11978532B2 (en) 2020-04-30 2024-05-07 Optum Services (Ireland) Limited Cross-variant polygenic predictive data analysis
US11610645B2 (en) 2020-04-30 2023-03-21 Optum Services (Ireland) Limited Cross-variant polygenic predictive data analysis
US11482302B2 (en) 2020-04-30 2022-10-25 Optum Services (Ireland) Limited Cross-variant polygenic predictive data analysis
US11574738B2 (en) 2020-04-30 2023-02-07 Optum Services (Ireland) Limited Cross-variant polygenic predictive data analysis
US11967430B2 (en) 2020-04-30 2024-04-23 Optum Services (Ireland) Limited Cross-variant polygenic predictive data analysis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOKINEN, P.: "Identifying Genetic Risk Factors In Canine Autoimmune Disorders.", ACADEMIC DISSERTATION., 28 January 2011 (2011-01-28), Retrieved from the Internet <URL:https://helda.helsinki.fi/bitstream/handle/10138/24488/identify.pdf> [retrieved on 20151008] *
TRUVE, K.: "Bioinformatics Mining For Disease Causing Mutations: Using The Dog Genome As A Model For Human Disease.", DOCTORAL THESIS., 2012, Retrieved from the Internet <URL:http://hunddna.slu.selartikelserie/truve_k_120920.pdf> [retrieved on 20151008] *
WILBE, M ET AL.: "Genome-Wide Association Mapping Identifies Multiple Loci For A Canine SLE-Related Disease Complex.", NAT GENET., vol. 42, no. 3, March 2010 (2010-03-01), pages 250 - 254 *
WILBE, M.: "Discovery Of A Novel Pathway For An SLE-Related Disease Complex In The Canine Breed Nova Scotia Duck Tolling Retriever.", SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES UPPSALA. DOCTORAL THESIS., 2013, Retrieved from the Internet <URL:http://pub.epsilon.siu.se/10229/1/wilbe_m_130415.pdf> [retrieved on 20151008] *

Also Published As

Publication number Publication date
WO2015184249A2 (en) 2015-12-03

Similar Documents

Publication Publication Date Title
WO2015184249A3 (en) Sle and sle-related disease-associated risk markers and uses thereof
EP3542331A4 (en) &#34;identifying an entity&#34;
CY1120988T1 (en) MOVEMENT DIAHREL INHIBITORS
CL2017000590A1 (en) Anti-cll-1 and immunoconjugate antibodies
CL2017001408A1 (en) Anti-cd79b antibodies and methods of use
WO2014152355A3 (en) Osteosarcoma-associated risk markers and uses thereof
DK3214927T3 (en) LIQUID COLLECTION SYSTEM FOR FLOWS ON THE FLOOR OF AN ANIMAL BREEDING INCLUSION
ZA201902996B (en) Stable solid composition based on an aromatic compound and uses thereof
WO2018071796A3 (en) Compositions and methods for identifying functional anti-tumor t cell responses
BR112017028470A2 (en) 6.6 high module nylon cables
FR3037569B1 (en) AXIAL MAGNETIC ATTRACTION DEVICE.
EP3492541A4 (en) Compositions based on emulsions of wax and particulate inorganic compounds for improved water-repellency, and the use thereof
FR3018672B1 (en) DEVICE FOR CONDITIONING AND APPLICATION.
BR112019006636A2 (en) low emission pre-vulcanization inhibitor for polyurethane foam
CL2016002256A1 (en) An improved process for the preparation of exametazyme
WO2014169204A3 (en) Sle and sle-related disease-associated risk markers and uses thereof
FR3047109B1 (en) COOLING ASSEMBLY OF AN INDUCTANCE DEVICE
BR112018013888A2 (en) diurnosid and / or cestrumosid animal feed additive
Thammishetty Educational Evaluation
Karaküçük Effects of accountants’ demographic characteristics on ethical behaviors
FR3016892B1 (en) DEVICE FOR PREHEATING AN ANODE ASSEMBLY.
WO2014160359A8 (en) Mast cell cancer-associated germ-line risk markers and uses thereof
Dixon Field Journal of JR Dixon (JRD Specimens 30722-30957)
Dixon Field Journal of JR Dixon (JRD Specimens 30622-30721)
TH66498B (en) Transmission equipment for vehicles

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15799423

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15799423

Country of ref document: EP

Kind code of ref document: A2