WO2015145117A1 - Wound dressing - Google Patents
Wound dressing Download PDFInfo
- Publication number
- WO2015145117A1 WO2015145117A1 PCT/GB2015/050839 GB2015050839W WO2015145117A1 WO 2015145117 A1 WO2015145117 A1 WO 2015145117A1 GB 2015050839 W GB2015050839 W GB 2015050839W WO 2015145117 A1 WO2015145117 A1 WO 2015145117A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- wound
- honey
- absorbent core
- fibres
- dressing according
- Prior art date
Links
- 235000012907 honey Nutrition 0.000 claims abstract description 73
- 230000002745 absorbent Effects 0.000 claims abstract description 38
- 239000002250 absorbent Substances 0.000 claims abstract description 38
- 239000006261 foam material Substances 0.000 claims abstract description 5
- 235000010443 alginic acid Nutrition 0.000 claims description 17
- 229920000615 alginic acid Polymers 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 17
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 16
- 229940072056 alginate Drugs 0.000 claims description 16
- 239000001814 pectin Substances 0.000 claims description 16
- 235000010987 pectin Nutrition 0.000 claims description 16
- 229920001277 pectin Polymers 0.000 claims description 16
- 240000003553 Leptospermum scoparium Species 0.000 claims description 10
- 235000016887 Leptospermum scoparium Nutrition 0.000 claims description 10
- 229920000433 Lyocell Polymers 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 229920005830 Polyurethane Foam Polymers 0.000 claims description 6
- 239000004744 fabric Substances 0.000 claims description 6
- 239000011496 polyurethane foam Substances 0.000 claims description 6
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 14
- 238000010790 dilution Methods 0.000 abstract description 3
- 239000012895 dilution Substances 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 85
- 208000027418 Wounds and injury Diseases 0.000 description 85
- 239000006260 foam Substances 0.000 description 29
- 239000000835 fiber Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 235000010410 calcium alginate Nutrition 0.000 description 6
- 239000000648 calcium alginate Substances 0.000 description 6
- 229960002681 calcium alginate Drugs 0.000 description 6
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 229920000297 Rayon Polymers 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241001514662 Leptospermum Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000003490 calendering Methods 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229940043370 chrysin Drugs 0.000 description 1
- 235000015838 chrysin Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000002803 maceration Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920006264 polyurethane film Polymers 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00217—Wound bandages not adhering to the wound
- A61F2013/00229—Wound bandages not adhering to the wound with alginate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00731—Plasters means for wound humidity control with absorbing pads
- A61F2013/0074—Plasters means for wound humidity control with absorbing pads containing foams
Definitions
- This invention relates to wound dressings, in particular, the invention concerns wound dressings that include honey.
- Honey is a mixture of sugars, water and other active ingredients such as vitamin C, catalase and chrysin, that are thought to act as antioxidants. As such, it has much greater activity than sugar alone.
- honeys such as manuka honey, produced from the plant species Leptospermum scoparium.
- honey have been shown to have high anti-bacterial, non-peroxide activity which inhibits the growth of various species of bacteria.
- honey can support wound healing through its anti-inflammatory action, its natural anti-bacterial properties, its debriding action and its stimulatory effect on granulation and epithelialisation.
- honey has been shown to have considerable wound- and ulcer-healing capacity and strong anti-microbial capacity even in moist healing environments.
- the wound contact surface of a wound dressing needs to maintain a moist layer over the wound to prevent adherence to the drying wound. It is known that for efficient wound healing the area of the wound should be kept moist, but the surrounding healthy skin should be kept dry to avoid maceration of the healthy skin. If a wound dressing cannot be cleanly removed from a wound, then a patient will suffer additional trauma.
- Gelling fibres such as alginate or pectin fibres are known for use in wound dressings. They have a greater capacity for absorbing liquid than standard textile fibres and, on absorbing liquid, they become moist and slippery. This prevents the dressing from adhering to the wound and therefore makes removal of the dressing easier.
- Dressings comprising honey are also known in the art. However, the honey capacity of the currently available dressings is limited and lower than desired. One reason for this is the fluid nature of honey. The honey incorporated in a dressing is liable to flow away from the site of the wound. In addition, if a wound produces a significant volume of exudate, the exudate may dilute the honey and exacerbate the problems associated with the fluid nature of the honey.
- a wound dressing comprising an absorbent core of foam material having a regular array of perforations formed therein, and a wound-contact layer bonded to a first face of the absorbent core and comprising gelling fibres, wherein at least the absorbent core is impregnated with honey.
- the wound dressing according to the invention is advantageous primarily in that it enables a larger volume of honey to be held in contact with a wound site.
- the presence of the wound-contact layer between the absorbent core and the wound site may reduce the rate at which honey is released from the dressing to the wound site.
- the dressing according to the invention may therefore increase the amount of honey delivered to the wound site, and/or it may prolong the duration of action of the honey.
- the perforations in the absorbent core provide pockets for the honey and result in an increased honey capacity.
- the absorbent core may absorb exudate from the wound, thereby reducing the rate at which honey is diluted and flushed away from the wound site. Again, this may prolong the action of the dressing.
- the absorbent core may also provide cushioning and may increase the conformability of the dressing. Furthermore, because the wound-contact layer contains gelling fibres, that layer becomes gelatinous in use, when exposed to wound exudate. This renders the dressing non-adherent and allows for atraumatic removal of the dressing.
- one face of the absorbent core is bonded to the wound-contact layer and the other face is bonded to a backing layer.
- the backing layer is identical to the wound-contact layer, ie the dressing may be symmetrical about the absorbent core.
- the backing layer is different to the wound-contact layer.
- the backing layer may be a non-gelling fabric layer, or it may be a plastics film, eg a polyurethane film of the general type that is widely used in wound dressings.
- Such a film is preferably sufficiently porous to permit the transmission of moisture vapour, but not so porous as to prevent the loss of liquid or to permit the ingress of bacteria.
- the foam material used in the absorbent core may be any suitable foam known in the art.
- the foam is an open-celled foam.
- the foam is a hydrophilic foam. More preferably, the hydrophilic foam is a polyurethane foam. Most preferably, the foam is an open-celled polyurethane foam.
- the open cellular structure allows exudate from a wound to pass through the foam as well as be absorbed by it. The structure is sufficiently open as to allow exudate to pass through it.
- the foam typically has a thickness of 0.5mm to 10mm, preferably from 1 mm to 4mm, and the foam most preferably has a thickness of 1 mm to 2mm.
- Foams are generally absorbent. If the foam is an open-celled foam it will have a higher absorbent capacity. This is advantageous in that the foam may wick away exudate from the wound. This can prevent the honey from becoming diluted and reduce the likelihood of the honey becoming sufficiently fluid to run away from the wound site.
- the perforated foam layer has perforations spaced regularly across the extent of the layer.
- the perforations may be any suitable shape, but are typically circular and have a diameter of from 3mm to 10mm, preferably 4mm to 8mm and most preferably about 5mm to about 7mm,
- the perforations may be arranged in any suitable pattern across the dressing but are most preferably arranged in a hexagonal array.
- the centre-to-centre separation of perforations in such an array may be between 7mm and 20mm, or between 10mm and 15mm. It should be understood, however, that any regular array of perforations may be appropriate for use in the invention.
- the perforations may, for instance, be square or rectangular and arranged in parallel lines, or they may be elongate slots in a herringbone arrangement, or they may be elliptical or triangular or any other suitable shape.
- the wound-contact layer has an open structure that allows wound exudate from a wound to pass through it as well as be absorbed by it. It also allows honey to pass from the dressing to the wound site.
- the wound-contact layer may be non-woven, knitted or woven. Most preferably, the wound-contact layer is a knitted material. Knitting is a process whereby fabric is formed by the interlocking of loops of yarn. A variety of knitting techniques are known in the art, and are suitable for use in the present invention.
- the wound facing layer comprises gelling fibres.
- Gelling fibres allow the dressing to be non-adherent and enable atraumatic removal of the dressing.
- Gelling fibres are also absorbent. Gelling fibres can absorb excess wound exudate and reduce the effects of dilution of the honey at the wound site.
- gelling fibre is meant in relation to the invention fibres that are capable of absorbing aqueous fluid, such as wound exudate, and which on absorbing liquid become gel-like, moist and slippery.
- the gelling fibres may have an absorbency of at least 2 grams 0,9% saline solution per gram of fibre, as measured by the free swell absorbency test (ie dispersing a known dry weight of fibre in the test liquid (saline) for sufficient time for the fibre to absorb liquid, removing the excess liquid by vacuum filtration, and measuring the increase in weight of the fibre).
- the absorbency may be considerably higher, eg at least 5g/g, or at least 10g/g, or at least 15g/g, or at least 25g/g.
- the gelling fibres may be any suitable gelling fibre known in the art, including pectin fibres, alginate fibres, fibres made from alginate and another
- polysaccharide polysaccharide, chitosan fibres, hyaluronic acid fibres, fibres of other
- the gelling fibres may be a combination or blend of different gelling fibres.
- Currently preferred gelling fibres are alginate fibres and pectin fibres.
- Alginates are high molecular weight, hydrophilic polymers, which are derived from seaweed and which form a gel on contact with aqueous fluids. Their hydrophilic nature encourages the absorption of liquid such as wound exudate, making them extremely useful in wound dressings.
- the alginate polymer is formed of two basic monomeric units, mannuronic acid and guluronic acid. Differing proportions of these units in the polymer alter the properties of the alginate.
- alginate polymers are associated with cations, and are normally produced in the form of sodium alginate, calcium alginate or a sodium/calcium alginate mix. Other forms, such as potassium alginate, are also known.
- the nature of the cation which is associated with the alginate polymer changes the properties of the alginate. For example, sodium alginate is water-soluble, whereas calcium alginate is not. By altering the alginate used in a wound dressing it is therefore possible to ensure that the final dressing displays the desired
- Pectins are a family of complex polysaccharides comprising 1 ,4-linked ⁇ -D- galactosyluronic residues, found primarily in the cell walls of terrestrial plants. Pectins can be separated into two main groups which have different gelling properties: low-methoxy and high-methoxy pectins. Low-methoxy pectins are pectins in which less than half the carbonyl groups in the chain of galacturonic residues are esterified with methanol, Low-methoxy pectins can form a gel in the presence of divalent cations (eg calcium), due to non-covalent ionic interactions between blocks of galacturonic acid residues and the divalent ion.
- divalent cations eg calcium
- High-methoxy pectins are those in which more than half of the carbonyl groups have been esterified with methanol. Such pectins can gel in the presence of sugar and acid, forming two-dimensional networks of pectin molecules in which the solvent (water) is immobilised with the sugar and acid co-solutes.
- Another class of gelling fibres that are known to be useful in absorbent wound dressings are those made from chemically-modified cellulose.
- carboxymethylated cellulose fibres may be used, eg in the form of sodium carboxymethyl cellulose.
- Such fibres preferably have a degree of substitution of at least 0.2 carboxymethyl groups per glucose unit, or at least 0.3 or at least 0.5.
- the wound-contact layer may comprise only gelling fibres. However, at least where the wound-contact layer is woven or knitted, it is preferred that it comprises a blend of gelling fibres and non-gelling fibres. Preferably the material comprises at least 50% w/w gelling fibres.
- the material may be formed from a mixture of yarns of gelling fibre and yarns of non-gelling fibre. More preferably, however, the material is formed, most preferably knitted, from a single yarn that is a blend of gelling and non-gelling fibres. Suitable yarns include those disclosed in
- the non-gelling fibres may be any suitable fibres known in the art, or may be a mixture of two or more non-gelling fibres.
- the non-ge!ing fibres may be textile fibres, and may be natural, eg cotton, may be natural fibres which have been modified eg DC!u!osic fibres such as viscose or lyocell (sold under the trade name TENCEL®), or they may be synthetic, eg polyester, polypropylene or polyamide.
- Different fibres have different characteristics in terms of tensile strength and absorbency, and appropriate non-gelling fibres may be chosen according to the desired characteristics of the wound dressing.
- a combination of two or more non-gelling fibres may be used in order to achieve the desired
- the non-gelling fibres are natural fibres which have been modified. More preferably, the non-gelling fibres are cellulosic fibres.
- the wound-contact layer may comprise a combination of alginate fibres and cellulosic fibres. In such cases, the wound-contact layer preferably comprises a combination of calcium alginate fibres and cellulosic fibres. More preferably, the wound-contact layer comprises calcium alginate and viscose, or calcium alginate and lyocell.
- the wound-contact layer may comprise a combination of pectin fibres and cellulosic fibres.
- the wound- contact layer preferably comprises a combination of pectin fibres and viscose, or pectin fibres and lyocell.
- the wound-contact layer retains its structural integrity after use in the wound dressing. Even when saturated with liquid, the structure retains sufficient integrity that it can be easily removed from the wound with little or no breakage or disintegration,
- the wound-contact layer is bonded to the perforated foam layer.
- the layers may be bonded by any suitable means known in the art.
- the layers are heat- bonded.
- the wound-contact layer is heat-bonded to the foam layer using a heat-fusible polymer layer.
- At least the perforated foam absorbent core of the dressing is impregnated with honey.
- honey it is preferable for both the absorbent core and the wound-contact layer to be impregnated with honey.
- the absorbent foam core may be impregnated with honey prior to being incorporated into the dressing, or the various layers of the dressing may be bonded together and then impregnated with honey. Impregnation with honey may take place by dipping the component(s) of the dressing that are to be impregnated in honey.
- the honey may be contained in a suitable vat through which those component(s) are passed in a continuous process.
- the dressing of the invention will in most instances be manufactured by bonding the material of the various layers together to form a stock material from which individual dressings are cut or otherwise separated.
- stock of dressing material that is impregnated with honey, followed by division of the stock material into individual dressings, rather than impregnation of individual pre- formed dressings.
- the perforations in the foam layer fill with honey, and the wound-contact layer (and, if it is of an appropriate material, the backing layer - which may be identical to the wound-contact layer) is saturated with honey.
- honey may be removed, for instance by passing the honey-impregnated material through calendaring rollers.
- the honey enters the perforations in the foam and impregnates the wound-contact layer.
- the perforations thus provide pockets for the honey and increase the honey capacity of the dressing.
- the honey is in direct contact with the wound.
- the wound-contact layer having an open structure, permits honey to be transmitted to the wound site.
- the wound-contact layer also constrains that flow of honey so that honey is not lost from the dressing excessively quickly.
- the wound-contact layer also permits wound exudate to be taken up by the absorbent core, thereby reducing dilution of the honey and the tendency for the honey to be washed away from the wound site by the wound exudate.
- individual dressings can be formed, eg by cutting out using a suitable punch or other cutter.
- the dressings may have any desired shape, but are most commonly square or rectangular.
- the size of the dressing may vary between a few centimetres in one or both of length and width, to a few tens of centimetres in one or both of length and width.
- the dressing may be square, with sides of up to 5cm, or up to 10cm, or up to 20cm or more
- the dressing may alternatively be rectangular, with a length of up to 5cm, or up to 10cm, or up to 20cm or more, and a width of up to 5cm, or up to 10cm or more,
- the honey may be any suitable honey.
- the honey is manuka honey or another honey produced by bees that have collected nectar from plants of the genus Leptospermum, eg Leptospermum scoparium (manuka) or Leptospermum poiyga!ifo!ium (jelly bush).
- these honeys are known to exhibit highly beneficial properties in wound healing, Where the perforations in the absorbent foam core are circular and are arranged in a regular hexagonal array, and where the whole dressing is impregnated with honey, the dressing may have an appearance reminiscent of a natural
- honeycomb Whilst that appearance is not in itself of technical significance, it may give the dressing a pleasing aesthetic, natural-looking appearance, which may be reassuring to patients and so may improve patient compliance.
- the dressing will generally be supplied with a releasable liner on one or both sides of the dressing.
- the releasable liner may cover the wound dressing prior to use, and be removed from the dressing immediately before application of the dressing to the wound, This reduces the risk of contamination of the wound dressing and facilitates handling of the dressing.
- the releasable liner may be of a suitable plastics sheet or a siliconised paper or the like.
- the re!easab!e liner may be a single sheet which covers a side of the wound dressing, or may be formed of two or more sheets.
- the releasable liner may further comprise a tab to enable the liner to be easily removed from the dressing before use.
- the parts may either overlap or abut and extend outwards from the wound dressing, thus providing an easy method for removal of the releasable liner.
- Sterilisation may be undertaken by conventional means, eg gamma-irradiation.
- Figure 1 is an exploded view of a dressing according to the invention prior to impregnation with honey
- Figure 2 is a perspective view of a dressing according to the invention
- Figure 3 is a schematic representation of the process of manufacturing a dressing according to the invention.
- FIGs 1 and 2 there is shown an embodiment of a dressing according to the invention, generally designated 1 .
- the dressing comprises a perforated polyurethane foam layer 2 and two knitted facing layers 3.
- the foam layer 2 is bonded to the facing layers 3 by heat-fusable polymer layers 4 which are interposed between the foam layer 2 and each of the facing layers 3.
- the layers are impregnated with manuka honey such that each of the perforations 5 is filled with honey and the facing layers 3 are saturated with honey.
- the foam layer is approximately 1 ,5mm thick.
- the perforations 5 are arranged across the full extent of the foam layer 2 in a hexagonal array.
- the perforations 5 have approximate diameter 5mm and are spaced between 10 and 15mm apart.
- the knitted facing layers 3 are knitted from a blended alginate and tencel yarn in a tricot ground fabric structure,
- the dressing 1 may be manufactured by the following general method (see Figure 3).
- the manufacturing method is a continuous process, in which the component layers of the dressing 1 are brought together to form a stock material that is then impregnated with honey. Individual dressings are then cut from the stock material and packaged.
- a laminate comprising the perforated foam layer 2, the heat-fusable polymer layers 4 and the knitted facing layers 3 is produced. These layers are bonded together by passing the layered sheets through a set of heated rollers 6. The heat-fusable polymer layers 4 melt and bond the perforated foam layer 2 to the two facing layers 3, The heat-fusible layers 4 are of a lightweight, so-called dryweb material that effectively disintegrates on heating and so does not occlude either the perforations 5 in the foam 2 or the gaps in the knitted structure of the facing layers 3.
- the laminate is passed through a dipping tank of manuka honey 7. Excess honey is calendered from the
- the dressing 1 may be cut to any suitable size or shape.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
A wound dressing comprising an absorbent core of foam material having a regular array of perforations formed therein, and a wound-contact layer bonded to a first face of the absorbent core and comprising gelling fibres, wherein at least the absorbent core is impregnated with honey. The perforations in the absorbent core result in increased honey capacity, while the absorbent core absorbs exudate, reducing dilution of the honey.
Description
Wound dressing
This invention relates to wound dressings, in particular, the invention concerns wound dressings that include honey.
Healing properties have long been associated with honey. Honey is a mixture of sugars, water and other active ingredients such as vitamin C, catalase and chrysin, that are thought to act as antioxidants. As such, it has much greater activity than sugar alone.
In particular, certain honeys such as manuka honey, produced from the plant species Leptospermum scoparium., have been shown to have high anti-bacterial, non-peroxide activity which inhibits the growth of various species of bacteria. As such, honey can support wound healing through its anti-inflammatory action, its natural anti-bacterial properties, its debriding action and its stimulatory effect on granulation and epithelialisation. In fact, honey has been shown to have considerable wound- and ulcer-healing capacity and strong anti-microbial capacity even in moist healing environments.
Different types of wound dressing are required to meet different clinical needs. However, there are several desirable characteristics that are common to all wound dressings. Pain-free removal and the ability to remove a dressing without trauma to the wound and the surrounding skin are two of the most important
characteristics. In order to prevent pain and trauma, the wound contact surface of a wound dressing needs to maintain a moist layer over the wound to prevent adherence to the drying wound. It is known that for efficient wound healing the area of the wound should be kept moist, but the surrounding healthy skin should be kept dry to avoid maceration of the healthy skin. If a wound dressing cannot be cleanly removed from a wound, then a patient will suffer additional trauma.
Gelling fibres such as alginate or pectin fibres are known for use in wound dressings. They have a greater capacity for absorbing liquid than standard textile
fibres and, on absorbing liquid, they become moist and slippery. This prevents the dressing from adhering to the wound and therefore makes removal of the dressing easier. Dressings comprising honey are also known in the art. However, the honey capacity of the currently available dressings is limited and lower than desired. One reason for this is the fluid nature of honey. The honey incorporated in a dressing is liable to flow away from the site of the wound. In addition, if a wound produces a significant volume of exudate, the exudate may dilute the honey and exacerbate the problems associated with the fluid nature of the honey.
There has now been devised an improved honey-containing dressing, which overcomes or substantially mitigates the above-mentioned and/or other shortcomings or disadvantages of the prior art.
According to the invention there is provided a wound dressing comprising an absorbent core of foam material having a regular array of perforations formed therein, and a wound-contact layer bonded to a first face of the absorbent core and comprising gelling fibres, wherein at least the absorbent core is impregnated with honey.
The wound dressing according to the invention is advantageous primarily in that it enables a larger volume of honey to be held in contact with a wound site. In addition, the presence of the wound-contact layer between the absorbent core and the wound site may reduce the rate at which honey is released from the dressing to the wound site. The dressing according to the invention may therefore increase the amount of honey delivered to the wound site, and/or it may prolong the duration of action of the honey. The perforations in the absorbent core provide pockets for the honey and result in an increased honey capacity. In addition, the absorbent core may absorb exudate from the wound, thereby reducing the rate at which honey is diluted and flushed away from the wound site. Again, this may prolong the action of the dressing. The absorbent core may also provide cushioning and may increase the conformability of the dressing. Furthermore,
because the wound-contact layer contains gelling fibres, that layer becomes gelatinous in use, when exposed to wound exudate. This renders the dressing non-adherent and allows for atraumatic removal of the dressing. In preferred embodiments of the invention, one face of the absorbent core is bonded to the wound-contact layer and the other face is bonded to a backing layer. Preferably, the backing layer is identical to the wound-contact layer, ie the dressing may be symmetrical about the absorbent core. This has the advantage that it eliminates the risk of the dressing being placed on the wound in the wrong orientation, and also allows for the possibility of the dressing being used first in one orientation and then being inverted, thus prolonging the useful life of the dressing and leading to cost-savings. In other embodiments, however, the backing layer is different to the wound-contact layer. The backing layer may be a non-gelling fabric layer, or it may be a plastics film, eg a polyurethane film of the general type that is widely used in wound dressings. Such a film is preferably sufficiently porous to permit the transmission of moisture vapour, but not so porous as to prevent the loss of liquid or to permit the ingress of bacteria.
The foam material used in the absorbent core may be any suitable foam known in the art. Usually, the foam is an open-celled foam. Preferably, the foam is a hydrophilic foam. More preferably, the hydrophilic foam is a polyurethane foam. Most preferably, the foam is an open-celled polyurethane foam. The open cellular structure allows exudate from a wound to pass through the foam as well as be absorbed by it. The structure is sufficiently open as to allow exudate to pass through it. The foam typically has a thickness of 0.5mm to 10mm, preferably from 1 mm to 4mm, and the foam most preferably has a thickness of 1 mm to 2mm.
Foams are generally absorbent. If the foam is an open-celled foam it will have a higher absorbent capacity. This is advantageous in that the foam may wick away exudate from the wound. This can prevent the honey from becoming diluted and reduce the likelihood of the honey becoming sufficiently fluid to run away from the wound site.
The perforated foam layer has perforations spaced regularly across the extent of the layer. The perforations may be any suitable shape, but are typically circular and have a diameter of from 3mm to 10mm, preferably 4mm to 8mm and most preferably about 5mm to about 7mm, The perforations may be arranged in any suitable pattern across the dressing but are most preferably arranged in a hexagonal array. Depending on the size of the perforations, the centre-to-centre separation of perforations in such an array may be between 7mm and 20mm, or between 10mm and 15mm. It should be understood, however, that any regular array of perforations may be appropriate for use in the invention. The perforations may, for instance, be square or rectangular and arranged in parallel lines, or they may be elongate slots in a herringbone arrangement, or they may be elliptical or triangular or any other suitable shape.
The wound-contact layer has an open structure that allows wound exudate from a wound to pass through it as well as be absorbed by it. It also allows honey to pass from the dressing to the wound site.
The wound-contact layer may be non-woven, knitted or woven. Most preferably, the wound-contact layer is a knitted material. Knitting is a process whereby fabric is formed by the interlocking of loops of yarn. A variety of knitting techniques are known in the art, and are suitable for use in the present invention.
The wound facing layer comprises gelling fibres. Gelling fibres allow the dressing to be non-adherent and enable atraumatic removal of the dressing. Gelling fibres are also absorbent. Gelling fibres can absorb excess wound exudate and reduce the effects of dilution of the honey at the wound site.
By "gelling fibre" is meant in relation to the invention fibres that are capable of absorbing aqueous fluid, such as wound exudate, and which on absorbing liquid become gel-like, moist and slippery. The gelling fibres may have an absorbency of at least 2 grams 0,9% saline solution per gram of fibre, as measured by the free swell absorbency test (ie dispersing a known dry weight of fibre in the test liquid (saline) for sufficient time for the fibre to absorb liquid, removing the excess liquid
by vacuum filtration, and measuring the increase in weight of the fibre). The absorbency may be considerably higher, eg at least 5g/g, or at least 10g/g, or at least 15g/g, or at least 25g/g. The gelling fibres may be any suitable gelling fibre known in the art, including pectin fibres, alginate fibres, fibres made from alginate and another
polysaccharide, chitosan fibres, hyaluronic acid fibres, fibres of other
polysaccharides or derived from gums, or chemically-modified cellulosic fibres, eg carboxymethyl cellulose (CMC). The gelling fibres may be a combination or blend of different gelling fibres.
Currently preferred gelling fibres are alginate fibres and pectin fibres.
Alginates are high molecular weight, hydrophilic polymers, which are derived from seaweed and which form a gel on contact with aqueous fluids. Their hydrophilic nature encourages the absorption of liquid such as wound exudate, making them extremely useful in wound dressings.
The alginate polymer is formed of two basic monomeric units, mannuronic acid and guluronic acid. Differing proportions of these units in the polymer alter the properties of the alginate. In addition to this, alginate polymers are associated with cations, and are normally produced in the form of sodium alginate, calcium alginate or a sodium/calcium alginate mix. Other forms, such as potassium alginate, are also known.
The nature of the cation which is associated with the alginate polymer changes the properties of the alginate. For example, sodium alginate is water-soluble, whereas calcium alginate is not. By altering the alginate used in a wound dressing it is therefore possible to ensure that the final dressing displays the desired
characteristics.
Pectins are a family of complex polysaccharides comprising 1 ,4-linked γ-D- galactosyluronic residues, found primarily in the cell walls of terrestrial plants.
Pectins can be separated into two main groups which have different gelling properties: low-methoxy and high-methoxy pectins. Low-methoxy pectins are pectins in which less than half the carbonyl groups in the chain of galacturonic residues are esterified with methanol, Low-methoxy pectins can form a gel in the presence of divalent cations (eg calcium), due to non-covalent ionic interactions between blocks of galacturonic acid residues and the divalent ion. High-methoxy pectins are those in which more than half of the carbonyl groups have been esterified with methanol. Such pectins can gel in the presence of sugar and acid, forming two-dimensional networks of pectin molecules in which the solvent (water) is immobilised with the sugar and acid co-solutes.
Another class of gelling fibres that are known to be useful in absorbent wound dressings are those made from chemically-modified cellulose. In particular, carboxymethylated cellulose fibres may be used, eg in the form of sodium carboxymethyl cellulose. Such fibres preferably have a degree of substitution of at least 0.2 carboxymethyl groups per glucose unit, or at least 0.3 or at least 0.5.
The wound-contact layer may comprise only gelling fibres. However, at least where the wound-contact layer is woven or knitted, it is preferred that it comprises a blend of gelling fibres and non-gelling fibres. Preferably the material comprises at least 50% w/w gelling fibres. The material may be formed from a mixture of yarns of gelling fibre and yarns of non-gelling fibre. More preferably, however, the material is formed, most preferably knitted, from a single yarn that is a blend of gelling and non-gelling fibres. Suitable yarns include those disclosed in
Internationa! Patent Application WO2013/064831 .
The combination of gelling fibre and non-gelling fibre in such blended yarns produces a strong, flexible yarn, even where there is a relatively low proportion of non-gelling fibre.
The non-gelling fibres may be any suitable fibres known in the art, or may be a mixture of two or more non-gelling fibres. The non-ge!!ing fibres may be textile fibres, and may be natural, eg cotton, may be natural fibres which have been
modified eg cei!u!osic fibres such as viscose or lyocell (sold under the trade name TENCEL®), or they may be synthetic, eg polyester, polypropylene or polyamide. Different fibres have different characteristics in terms of tensile strength and absorbency, and appropriate non-gelling fibres may be chosen according to the desired characteristics of the wound dressing. In addition, a combination of two or more non-gelling fibres may be used in order to achieve the desired
characteristics. Preferably, the non-gelling fibres are natural fibres which have been modified. More preferably, the non-gelling fibres are cellulosic fibres. Thus, in some embodiments of the invention, the wound-contact layer may comprise a combination of alginate fibres and cellulosic fibres. In such cases, the wound-contact layer preferably comprises a combination of calcium alginate fibres and cellulosic fibres. More preferably, the wound-contact layer comprises calcium alginate and viscose, or calcium alginate and lyocell.
In other embodiments of the invention, the wound-contact layer may comprise a combination of pectin fibres and cellulosic fibres. In such cases, the wound- contact layer preferably comprises a combination of pectin fibres and viscose, or pectin fibres and lyocell.
Preferably the wound-contact layer retains its structural integrity after use in the wound dressing. Even when saturated with liquid, the structure retains sufficient integrity that it can be easily removed from the wound with little or no breakage or disintegration,
The wound-contact layer is bonded to the perforated foam layer. The layers may be bonded by any suitable means known in the art. Preferably the layers are heat- bonded. Most preferably, the wound-contact layer is heat-bonded to the foam layer using a heat-fusible polymer layer.
At least the perforated foam absorbent core of the dressing is impregnated with honey. In practice, however, it is preferable for both the absorbent core and the wound-contact layer to be impregnated with honey. Indeed, especially where the
dressing is symmetrical, with the absorbent core bonded to a wound-contact layer and a backing layer (which may be identical to the wound-contact layer), the whole dressing may be impregnated with honey. Thus, the absorbent foam core may be impregnated with honey prior to being incorporated into the dressing, or the various layers of the dressing may be bonded together and then impregnated with honey. Impregnation with honey may take place by dipping the component(s) of the dressing that are to be impregnated in honey. For instance, the honey may be contained in a suitable vat through which those component(s) are passed in a continuous process. It should be understood that in practice the dressing of the invention will in most instances be manufactured by bonding the material of the various layers together to form a stock material from which individual dressings are cut or otherwise separated. Thus, it will most commonly be that stock of dressing material that is impregnated with honey, followed by division of the stock material into individual dressings, rather than impregnation of individual pre- formed dressings. When the material is impregnated, the perforations in the foam layer fill with honey, and the wound-contact layer (and, if it is of an appropriate material, the backing layer - which may be identical to the wound-contact layer) is saturated with honey. Excess honey may be removed, for instance by passing the honey-impregnated material through calendaring rollers.
The honey enters the perforations in the foam and impregnates the wound-contact layer. The perforations thus provide pockets for the honey and increase the honey capacity of the dressing. The results in a dressing with a high honey capacity. In use, the honey is in direct contact with the wound. The wound-contact layer, having an open structure, permits honey to be transmitted to the wound site.
However, the wound-contact layer also constrains that flow of honey so that honey is not lost from the dressing excessively quickly. The wound-contact layer also permits wound exudate to be taken up by the absorbent core, thereby reducing dilution of the honey and the tendency for the honey to be washed away from the wound site by the wound exudate.
After the stock material has been impregnated with honey, individual dressings can be formed, eg by cutting out using a suitable punch or other cutter. The
dressings may have any desired shape, but are most commonly square or rectangular. The size of the dressing may vary between a few centimetres in one or both of length and width, to a few tens of centimetres in one or both of length and width. Thus, the dressing may be square, with sides of up to 5cm, or up to 10cm, or up to 20cm or more, The dressing may alternatively be rectangular, with a length of up to 5cm, or up to 10cm, or up to 20cm or more, and a width of up to 5cm, or up to 10cm or more,
The honey may be any suitable honey. Preferably the honey is manuka honey or another honey produced by bees that have collected nectar from plants of the genus Leptospermum, eg Leptospermum scoparium (manuka) or Leptospermum poiyga!ifo!ium (jelly bush). As noted above, these honeys are known to exhibit highly beneficial properties in wound healing, Where the perforations in the absorbent foam core are circular and are arranged in a regular hexagonal array, and where the whole dressing is impregnated with honey, the dressing may have an appearance reminiscent of a natural
honeycomb, Whilst that appearance is not in itself of technical significance, it may give the dressing a pleasing aesthetic, natural-looking appearance, which may be reassuring to patients and so may improve patient compliance.
The dressing will generally be supplied with a releasable liner on one or both sides of the dressing. The releasable liner may cover the wound dressing prior to use, and be removed from the dressing immediately before application of the dressing to the wound, This reduces the risk of contamination of the wound dressing and facilitates handling of the dressing.
Such releasable liners are commonly used on wound dressings known in the art, and suitable materials which can be employed in the present invention will be familiar to the skilled worker. For example, the releasable liner may be of a suitable plastics sheet or a siliconised paper or the like.
The re!easab!e liner may be a single sheet which covers a side of the wound dressing, or may be formed of two or more sheets. The releasable liner may further comprise a tab to enable the liner to be easily removed from the dressing before use. In particular, where the releasable liner is formed of two or more parts, the parts may either overlap or abut and extend outwards from the wound dressing, thus providing an easy method for removal of the releasable liner.
After individual dressings have been produced, they are preferably individually packaged and sterilised. Sterilisation may be undertaken by conventional means, eg gamma-irradiation.
The invention will now be described in greater detail, by way of example only, with reference to the accompanying drawings, in which Figure 1 is an exploded view of a dressing according to the invention prior to impregnation with honey;
Figure 2 is a perspective view of a dressing according to the invention; and Figure 3 is a schematic representation of the process of manufacturing a dressing according to the invention.
In Figures 1 and 2 there is shown an embodiment of a dressing according to the invention, generally designated 1 . The dressing comprises a perforated polyurethane foam layer 2 and two knitted facing layers 3. The foam layer 2 is bonded to the facing layers 3 by heat-fusable polymer layers 4 which are interposed between the foam layer 2 and each of the facing layers 3. The layers are impregnated with manuka honey such that each of the perforations 5 is filled with honey and the facing layers 3 are saturated with honey.
The foam layer is approximately 1 ,5mm thick. The perforations 5 are arranged across the full extent of the foam layer 2 in a hexagonal array. The perforations 5 have approximate diameter 5mm and are spaced between 10 and 15mm apart.
The knitted facing layers 3 are knitted from a blended alginate and tencel yarn in a tricot ground fabric structure, The dressing 1 may be manufactured by the following general method (see Figure 3).
The manufacturing method is a continuous process, in which the component layers of the dressing 1 are brought together to form a stock material that is then impregnated with honey. Individual dressings are then cut from the stock material and packaged.
First a laminate comprising the perforated foam layer 2, the heat-fusable polymer layers 4 and the knitted facing layers 3 is produced. These layers are bonded together by passing the layered sheets through a set of heated rollers 6. The heat-fusable polymer layers 4 melt and bond the perforated foam layer 2 to the two facing layers 3, The heat-fusible layers 4 are of a lightweight, so-called dryweb material that effectively disintegrates on heating and so does not occlude either the perforations 5 in the foam 2 or the gaps in the knitted structure of the facing layers 3. Once the layers are bonded together, the laminate is passed through a dipping tank of manuka honey 7. Excess honey is calendered from the
impregnated laminate by a set of rollers 8 and collected in the dipping tank 7. A release liner 9 is applied to the impregnated laminate, and individual dressings 1 are cut out using a reciprocating punch 10 and packaged. The packages may then be sterilised, eg by gamma-irradiation.
The dressing 1 may be cut to any suitable size or shape.
Claims
1 . A wound dressing comprising an absorbent core of foam material having a regular array of perforations formed therein, and a wound-contact layer bonded to a first face of the absorbent core and comprising gelling fibres, wherein at least the absorbent core is impregnated with honey.
2. A wound dressing according to any preceding claim, wherein the foam material of the absorbent core is a polyurethane foam material.
3. A wound dressing according to any preceding claim, wherein a backing layer is bonded to the opposite face of the absorbent core to the wound-contact layer.
4. A wound dressing according to any preceding claim, wherein the backing layer is identical to the wound-contact layer.
5. A wound dressing according to any preceding claim, wherein the
perforations in the absorbent core are between 3mm and 10mm in diameter.
6. A wound dressing according to any preceding claim, wherein the
perforations in the absorbent core are about 5mm to about 7mm in diameter.
7. A wound dressing according to any preceding claim, wherein the absorbent core is between 0.5mm and 10mm thick.
8. A wound dressing according to any preceding claim, wherein the absorbent core is between 1 mm and 4mm thick.
9. A wound dressing according to any preceding claim, wherein the absorbent core is between 1 mm and 2mm thick.
10. A wound dressing according to any preceding claim, wherein the wound- contact layer is knitted.
1 1 . A wound dressing according to any preceding claim, wherein the gelling fibres are alginate gelling fibres.
12. A wound dressing according to any of Claims 1 to 10, wherein the gelling fibres are pectin gelling fibres.
13. A wound dressing according to any of Claims 1 to 10, wherein the gelling fibres are modified CMC gelling fibres.
14. A wound dressing according to any preceding claim, wherein the wound- contact layer comprises lyocell fibres.
15. A wound dressing according to Claim 10, wherein the wound-contact layer is a knitted fabric of blended yarn comprising gelling and non-gelling fibres.
16. A wound dressin according to Claim 15, wherein the yarn comprises a blend of alginate fibres and cellulosic fibres.
17. A wound dressing according to any preceding claim, wherein the absorbent core is heat bonded to the wound-contact layer.
18. A wound dressing according to any preceding claim, wherein the honey is manuka honey.
19. A dressing according to Claim 1 , wherein
the absorbent core is a polyurethane foam and the perforations are approximately 5mm in diameter and spaced between 10mm and 15mm apart; the wound-contact layer is a knitted alginate and lyocell fabric;
the layers are heat bonded together; and
the honey is manuka honey.
20. A dressing according to Claim 1 , wherein
the absorbent core is a polyurethane foam and the perforations are approximately 5mm in diameter and spaced between 10mm and 15mm apart; the wound-contact layer and the backing layer are a knitted alginate and lyocell fabric;
the layers are heat bonded together; and
the honey is manuka honey.
21 . A dressing substantially as hereinbefore described and as illustrated in the accompanying Figures 1 and 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1405284.9 | 2014-03-25 | ||
GB1405284.9A GB2524510B (en) | 2014-03-25 | 2014-03-25 | Wound dressing impregnated with honey |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015145117A1 true WO2015145117A1 (en) | 2015-10-01 |
Family
ID=50686841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2015/050839 WO2015145117A1 (en) | 2014-03-25 | 2015-03-20 | Wound dressing |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2524510B (en) |
WO (1) | WO2015145117A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018217621A1 (en) * | 2017-05-22 | 2018-11-29 | Kci Usa, Inc. | Elastically deformable wound dressings |
US10968543B2 (en) | 2011-12-01 | 2021-04-06 | Convatec Technologies Inc. | Wound dressing for use in vacuum therapy |
US11116884B2 (en) | 2010-12-08 | 2021-09-14 | Convatec Technologies Inc. | Integrated system for assessing wound exudates |
US11135315B2 (en) | 2010-11-30 | 2021-10-05 | Convatec Technologies Inc. | Composition for detecting biofilms on viable tissues |
US11241525B2 (en) | 2010-12-08 | 2022-02-08 | Convatec Technologies Inc. | Wound exudate monitor accessory |
US11241339B2 (en) | 2011-11-29 | 2022-02-08 | Convatec Inc. | Perforated binder for laminated wound dressing |
US11266774B2 (en) | 2016-07-08 | 2022-03-08 | Convatec Technologies Inc. | Fluid collection apparatus |
US11286601B2 (en) | 2012-12-20 | 2022-03-29 | Convatec Technologies, Inc. | Processing of chemically modified cellulosic fibres |
US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
US11452808B2 (en) | 2016-07-08 | 2022-09-27 | Convatec Technologies Inc. | Fluid flow sensing |
US11458044B2 (en) | 2008-09-29 | 2022-10-04 | Convatec Technologies Inc. | Wound dressing |
US11583430B2 (en) | 2011-09-02 | 2023-02-21 | Convatec Ltd. | Skin contact material |
US11596554B2 (en) | 2016-07-08 | 2023-03-07 | Convatec Technologies Inc. | Flexible negative pressure system |
US11628093B2 (en) | 2008-05-08 | 2023-04-18 | Convatec Technologies, Inc. | Wound dressing |
US11723808B2 (en) | 2016-03-30 | 2023-08-15 | Convatec Technologies Inc. | Detecting microbial infections in wounds |
US11740241B2 (en) | 2016-03-30 | 2023-08-29 | Synovo Gmbh | Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds |
US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104812343B (en) | 2012-07-16 | 2019-06-18 | 史密夫和内修有限公司 | Negative pressure wound closure device |
JP6407954B2 (en) | 2013-03-13 | 2018-10-17 | スミス アンド ネフュー インコーポレイテッド | Negative pressure wound closure device and system and method of use in wound treatment with negative pressure |
GB201408553D0 (en) * | 2014-05-14 | 2014-06-25 | Brightwake Ltd | Wound dressing |
EP3288509B1 (en) | 2015-04-29 | 2022-06-29 | Smith & Nephew, Inc | Negative pressure wound closure device |
US20200000640A1 (en) * | 2018-06-29 | 2020-01-02 | Milliken & Company | Multi-Layer Wound Care Device Having Absorption and Fluid Transfer Properties |
EP3893825A1 (en) | 2018-12-13 | 2021-10-20 | University of Massachusetts | Negative pressure wound closure devices and methods |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2537494A1 (en) * | 2006-10-02 | 2012-12-26 | Birgit Riesinger | Wound care article for extraction and control of wound fluids |
WO2013064831A1 (en) * | 2011-11-01 | 2013-05-10 | Brightwake Limited | Wound dressings, and yarn useful therein |
EP2659865A1 (en) * | 2012-05-04 | 2013-11-06 | Advanced Medical Solutions Limited | Wound Dressing |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE505000C2 (en) * | 1996-05-14 | 1997-06-09 | Moelnlycke Ab | Wound dressing and manufacturing process therefore |
SE533843C2 (en) * | 2009-06-15 | 2011-02-08 | Moelnlycke Health Care Ab | Wound pad comprising a body of compressed open cell foam material |
GB2493960B (en) * | 2011-08-25 | 2013-09-18 | Brightwake Ltd | Non-adherent wound dressing |
EP3072533B1 (en) * | 2011-09-26 | 2019-11-06 | BSN medical GmbH | Improved wound dressing |
-
2014
- 2014-03-25 GB GB1405284.9A patent/GB2524510B/en active Active
-
2015
- 2015-03-20 WO PCT/GB2015/050839 patent/WO2015145117A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2537494A1 (en) * | 2006-10-02 | 2012-12-26 | Birgit Riesinger | Wound care article for extraction and control of wound fluids |
WO2013064831A1 (en) * | 2011-11-01 | 2013-05-10 | Brightwake Limited | Wound dressings, and yarn useful therein |
EP2659865A1 (en) * | 2012-05-04 | 2013-11-06 | Advanced Medical Solutions Limited | Wound Dressing |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11628093B2 (en) | 2008-05-08 | 2023-04-18 | Convatec Technologies, Inc. | Wound dressing |
US11458044B2 (en) | 2008-09-29 | 2022-10-04 | Convatec Technologies Inc. | Wound dressing |
US11135315B2 (en) | 2010-11-30 | 2021-10-05 | Convatec Technologies Inc. | Composition for detecting biofilms on viable tissues |
US11241525B2 (en) | 2010-12-08 | 2022-02-08 | Convatec Technologies Inc. | Wound exudate monitor accessory |
US11116884B2 (en) | 2010-12-08 | 2021-09-14 | Convatec Technologies Inc. | Integrated system for assessing wound exudates |
US11583430B2 (en) | 2011-09-02 | 2023-02-21 | Convatec Ltd. | Skin contact material |
US11241339B2 (en) | 2011-11-29 | 2022-02-08 | Convatec Inc. | Perforated binder for laminated wound dressing |
US10968543B2 (en) | 2011-12-01 | 2021-04-06 | Convatec Technologies Inc. | Wound dressing for use in vacuum therapy |
US11286601B2 (en) | 2012-12-20 | 2022-03-29 | Convatec Technologies, Inc. | Processing of chemically modified cellulosic fibres |
US11723808B2 (en) | 2016-03-30 | 2023-08-15 | Convatec Technologies Inc. | Detecting microbial infections in wounds |
US11740241B2 (en) | 2016-03-30 | 2023-08-29 | Synovo Gmbh | Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds |
US11266774B2 (en) | 2016-07-08 | 2022-03-08 | Convatec Technologies Inc. | Fluid collection apparatus |
US11452808B2 (en) | 2016-07-08 | 2022-09-27 | Convatec Technologies Inc. | Fluid flow sensing |
US11596554B2 (en) | 2016-07-08 | 2023-03-07 | Convatec Technologies Inc. | Flexible negative pressure system |
WO2018217621A1 (en) * | 2017-05-22 | 2018-11-29 | Kci Usa, Inc. | Elastically deformable wound dressings |
CN110785151A (en) * | 2017-05-22 | 2020-02-11 | 凯希美国公司 | Elastically deformable wound dressing |
US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
Also Published As
Publication number | Publication date |
---|---|
GB2524510B (en) | 2020-02-19 |
GB201405284D0 (en) | 2014-05-07 |
GB2524510A (en) | 2015-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2015145117A1 (en) | Wound dressing | |
EP3296436B1 (en) | Wound dressings, and fabric useful therein | |
US20220142822A1 (en) | Absorbent wound dressings | |
CA2356329C (en) | Multi-layered wound dressing | |
CA2556151C (en) | Multi layered wound dressing | |
JP6621328B2 (en) | Wound dressing | |
GB2568101A (en) | Antimicrobial dressing | |
JP2015519137A5 (en) | ||
MX2012005373A (en) | A component for a wound dressing. | |
EP2659865A1 (en) | Wound Dressing | |
GB2380945A (en) | Multi-layered wound dressing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 15715366 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 15715366 Country of ref document: EP Kind code of ref document: A1 |