WO2015140348A3 - Use of dj-1 deglycase activity - Google Patents

Use of dj-1 deglycase activity Download PDF

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Publication number
WO2015140348A3
WO2015140348A3 PCT/EP2015/056117 EP2015056117W WO2015140348A3 WO 2015140348 A3 WO2015140348 A3 WO 2015140348A3 EP 2015056117 W EP2015056117 W EP 2015056117W WO 2015140348 A3 WO2015140348 A3 WO 2015140348A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycation
protein
interest
molecule
preventing
Prior art date
Application number
PCT/EP2015/056117
Other languages
French (fr)
Other versions
WO2015140348A2 (en
WO2015140348A9 (en
Inventor
Gilbert RICHARME
Aazdine Lamouri
Original Assignee
Centre National De La Recherche Scientifique (Cnrs)
Universite Paris Diderot Paris 7
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique (Cnrs), Universite Paris Diderot Paris 7 filed Critical Centre National De La Recherche Scientifique (Cnrs)
Publication of WO2015140348A2 publication Critical patent/WO2015140348A2/en
Publication of WO2015140348A9 publication Critical patent/WO2015140348A9/en
Publication of WO2015140348A3 publication Critical patent/WO2015140348A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates generally to the modification of molecules, in particular of proteins and nucleic acids, called glycation, which results in formation of advanced glycation endproducts and protein or nucleic acid crosslinks. The present invention provides products, and more particularly enzymes, that are useful for preventing or reversing protein and nucleic acid glycation. The invention in particular relates to an in vitro method for preventing and/or reversing glycation of a molecule of interest, said method comprising the step of bringing together the molecule of interest and a DJ-1 protein and/or one of its homologs.
PCT/EP2015/056117 2014-03-21 2015-03-23 Use of dj-1 deglycase activity WO2015140348A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305409 2014-03-21
EP14305409.6 2014-03-21

Publications (3)

Publication Number Publication Date
WO2015140348A2 WO2015140348A2 (en) 2015-09-24
WO2015140348A9 WO2015140348A9 (en) 2015-11-19
WO2015140348A3 true WO2015140348A3 (en) 2016-01-07

Family

ID=50397081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/056117 WO2015140348A2 (en) 2014-03-21 2015-03-23 Use of dj-1 deglycase activity

Country Status (1)

Country Link
WO (1) WO2015140348A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017132703A (en) * 2016-01-26 2017-08-03 オリザ油化株式会社 Carbonylation inhibitor
EP3219326A1 (en) 2016-03-14 2017-09-20 Institut Catalá De Ciencies Cardiovasculars (ICCC) Prevention and/or treatment of ischemia or ischemia/reperfusion injury
EP4375379A1 (en) * 2022-11-24 2024-05-29 Bioc3 Bioproduction of glycolic acid from glyoxal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010058364A1 (en) * 2008-11-21 2010-05-27 Xl'oreal Cosmetic and therapeutic use of proteins of dj-1 type for treating skin dryness
KR20130125630A (en) * 2012-05-09 2013-11-19 한국과학기술원 Human dj-1 protein or its homologs having novel glyoxalase activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2016015B (en) 1978-01-22 1982-05-06 Hayashibara Co Method of preparing interferon and preparations containing interferon

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010058364A1 (en) * 2008-11-21 2010-05-27 Xl'oreal Cosmetic and therapeutic use of proteins of dj-1 type for treating skin dryness
KR20130125630A (en) * 2012-05-09 2013-11-19 한국과학기술원 Human dj-1 protein or its homologs having novel glyoxalase activity

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHANGHAN LEE ET AL: "Glyoxal detoxification in Escherichia coli K-12 by NADPH dependent aldo-keto reductases", THE JOURNAL OF MICROBIOLOGY, vol. 51, no. 4, 1 August 2013 (2013-08-01), pages 527 - 530, XP055149649, ISSN: 1225-8873, DOI: 10.1007/s12275-013-3087-8 *
EMILE VAN SCHAFTINGEN ET AL: "Enzymatic repair of Amadori products", AMINO ACIDS ; THE FORUM FOR AMINO ACID AND PROTEIN RESEARCH, SPRINGER-VERLAG, VI, vol. 42, no. 4, 22 October 2010 (2010-10-22), pages 1143 - 1150, XP035024616, ISSN: 1438-2199, DOI: 10.1007/S00726-010-0780-3 *
J.-Y. LEE ET AL: "Human DJ-1 and its homologs are novel glyoxalases", HUMAN MOLECULAR GENETICS, vol. 21, no. 14, 20 April 2012 (2012-04-20), pages 3215 - 3225, XP055123296, ISSN: 0964-6906, DOI: 10.1093/hmg/dds155 *
KRISHNA P. SUBEDI ET AL: "Hsp31 of Escherichia coli K-12 is glyoxalase III", MOLECULAR MICROBIOLOGY, vol. 81, no. 4, 6 August 2011 (2011-08-06), pages 926 - 936, XP055149696, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.2011.07736.x *
S. HASIM ET AL: "A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal in Candida albicans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 3, 3 December 2013 (2013-12-03), pages 1662 - 1674, XP055141169, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.505784 *

Also Published As

Publication number Publication date
WO2015140348A2 (en) 2015-09-24
WO2015140348A9 (en) 2015-11-19

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