WO2015136030A1

WO2015136030A1 - Composition for use in the treatment of fatigue, concentration difficulties, withdrawal symptoms, headaches and colds, in particular reduction in productivity, hangovers and tiredness

Info

Publication number: WO2015136030A1
Application number: PCT/EP2015/055149
Authority: WO
Inventors: Jürgen RUHLMANN
Original assignee: Ruhlmann Jürgen
Priority date: 2014-03-13
Filing date: 2015-03-12
Publication date: 2015-09-17
Also published as: DE102014103443A1

Abstract

The invention relates to a composition comprising NADH and D-galactose for use in the treatment of fatigue, concentration difficulties, withdrawal symptoms, headaches and colds and in particular reduction in productivity, hangovers and tiredness, in particular also comprising vitamins and/or co enzymes and/or minerals.

Description

Composition for use in the treatment of fatigue,

Lack of concentration, withdrawal symptoms, headaches and

The present invention relates to a composition comprising NADH and D-galactose for the prevention of fatigue, lack of concentration,

Withdrawal symptoms, headaches and colds, and in particular the use for treatment in case of performance decline, hangover and

Fatigue by using a specific combination of vitamins, coenzymes,

Minerals and galactose.

It is known to use melatonin as a drug for faster adaptation

Time shifts, z. B. after long-haul flights to administer. Melatonin is a tryptophan derivative, it is produced by the so-called pineal gland. In the pinealocytes, the cells of this gland, tryptophan is converted from the blood via several biosynthesis steps to melatonin. Melatonin is in the US as

Nutritional supplement, but not approved as a medicinal product. In the

Federal Republic of Germany, melatonin preparations are not available on the open market, only in the form of the drug Circadin. The combination of the above substances stimulates u. a. the formation of melatonin. As far as is known today, melatonin has the effect described above due to the following mechanistic explanations: The circulating in the circulation melatonin acts mainly at central binding sites in certain areas of the

Hypothalamus and adenohypophysis. As far as is known, the show

Melatonin concentrations in human serum have a circadian pattern with high concentrations at night and low during the day. This pattern is created by the symmetrical innervation of the pineal organ. The daily light-dark change is perceived in mammals via the retina. This information is then forwarded neuronally via the retinohypothalamic tract to the suprachiasmatic nucleus (SCH), the so-called circadian clock. Postganglionic sympathetic fibers, which originate from the superior cervical ganglia (GCS), reach the pineal organ. During the dark phase, these fibers are stimulated by the activity of the SCH, resulting in release of the neurotransmitter

Norepinephrine leads to the nerve endings in the pineal organ. noradrenaline interacts with predominantly ß-adrenergic receptors on the membrane of

Pinealocytes and stimulates the activity of N-acetyltransferase via the cAMP second measuring system. This reaction represents, according to current knowledge, the rate-limiting step in melatonin synthesis.

On the melatonin system described above, light acts as a time tissue that synchronizes the circadian rhythm. In light exposure, it comes to a

Adjustment of norepinephrine release. This results in an inhibition of melatonin synthesis and thus follows a decrease in the concentration of melatonin in the blood. In humans, melatonin in serum has a half-life of about 35 to 50 minutes. Melatonin thus acts as an endocrine signal for the length of the night, because the duration of nocturnal melatonin delivery is proportional to the length of the night

Dark phase. The organism is thus able to determine the current day and season in which it is based on the melatonin profile. At the

People who show less pronounced seasonal adaptations than animals, melatonin plays a role in the regulation of the sleep-wake cycle, which is why melatonin is successfully used to facilitate adaptation after long-haul flights, so-called jet lag (ARENDT J., ALDHOUS M., MARKS M. (1987): Some effects of jet-long and their treatment by melatonin; Ergonomics 30: 1393-1397 (1987); ARENDT J., ALDHOUS M., MARKS V. (1986): Alleviation of jetlag by melatonin: preliminary results of controlled double-blind trials, BMJ 292: 1 170.

From US 2003/0021772 A1 it is known to use NADH alone for the relief of disorders based on sleep deprivation or jet lag.

WO 95/17199 A1 describes the use of galactose for the treatment of fatigue.

The object of the present invention is to provide an alternative to melatonin or NADH alone as a means of treating fatigue, lack of concentration,

To provide withdrawal symptoms, headaches and colds, and in particular, performance degradation, hangover and fatigue.

This object is achieved by the reproduced in claim 1 composition. According to the invention, it has been recognized that a composition comprising NADH and D-galactose for the treatment of fatigue, lack of concentration,

Withdrawal symptoms, headaches and colds and in particular from performance degradation, hangover and fatigue is appropriate

NADH is a coenzyme and the energetic, reduced form of NAD +. It serves as an energy-supplying coenzyme of the respiratory chain in oxidative metabolism, whereby ATP is generated. During the oxidation of NADH, this releases electrons and transfers them to oxygen as part of the intracellular oxyhydrogen gas reaction, resulting in NAD + and water. NAD + is u. a. also a coenzyme of for example the

Alcohol hydrogenase that oxidizes alcohol. NAD + is in the body on the one hand from niacin (vitamin B3, nicotinic acid) or nicotinamide, on the other hand from the

Degradation products of the amino acid tryptophan produced. These two starting materials are essential, so that deficiency symptoms of NAD + are possible, but this is rare because of the redundancy of both metabolic pathways.

Due to the reduced intake of niacin and tryptophan today, low normal NAD + levels appear more frequently.

NADH is one of the strongest antioxidants, the effect is on the one hand, the oxidation processes in the body, ie degradation processes by the reaction with oxygen, halt or slow down and on the other hand, the cell aggressive or polluting substances from the environment.

NADH plays a key role in energy production in particular, as it is the most important electron transporter in energy-producing processes. Without the action of NADH, humans can not optimally mobilize their energy. He feels energyless, tired and beaten off.

Due to our current way of life / nutrition, the supply of NADH is no longer sufficiently secured, z. B. by cooking meat and vegetables already lost much of the NADH effect.

The more NADH the cell has, the more energy the cell can produce. NADH stimulates or accelerates the production of the body's own "happiness hormones" dopamine and norepinephrine

Concentration and individual performance, including the general mood, the motivation and the individual energy potential, the

Improvement of any capacity is improved. NADH reduces jet lag, can compensate for lack of sleep and also increase libido. Since NADH effectively combats free radicals, the body cells are also sustainably protected (literature Prof. Dr. J. Birkmayer: NADH (coenzyme 1), biological function and therapeutic applications, DVD-Wissen.com).

Galactose is a naturally occurring simple sugar. In contrast to glucose, galactose can enter the cell, especially the brain cell, independently of the insulin via a concentration gradient. There galactose is rapidly converted completely into glucose, which improves brain function.

In particular, it has been found that the composition is particularly effective if it further comprises at least one or more substances selected from the group consisting of L-tryptophan, nicotinic acid or nicotinamide (vitamin B3), vitamin B2, vitamin B12, magnesium, L-carnitine, coenzyme Q10, vitamin C, inositol,

Dimethylaminoethanol or precursor of the aforementioned comprises.

Precursors are understood as meaning in particular "precursors" of the substances mentioned, which are converted by the body into the substances mentioned.Typtophan is an aromatic amino acid and is a constituent of proteins and peptides.It can not be produced in the human organism L-tryptophan is the precursor of serotonin Stress - and the resulting increased cortisol levels - leads to activation of the tryptophan-degrading enzyme tryptophan pyrrolase Over-dosing of L-tryptophan is difficult because L-tryptophan itself is the major activator of its degrading enzyme tryptophan pyrrolase.

Niacin or nicotinic acid is a vitamin from the B-complex. It is found in all living cells and forms an important building block of various coenzymes, in this form it is central to the metabolism of Proteins, fats and carbohydrates. Nicotinic acid has an antioxidant effect and is also important for the regeneration of skin muscles, nerves and DNA. The average daily requirement for women is 13 to 15 mg, for men 15 to 20 mg.

Coenzyme Q10, or even ubiquinone 10 is partly about the food

recorded, but also produced in the body itself. It participates as a coenzyme in oxidative phosphorylation, which generates 95% of total body energy (ATP) in the controlled oxyhydrogen reaction, and the electrons used to reduce ubiquinone are derived from NADH oxidation.

Vitamin B complex: In this vitamin group are eight vitamins

summarized, all of which serve as precursors for coenzymes. They are B1 thiamine, B2, rhiboflavine, B6 pyridoxine, B12 cobalamin, B7 biotin, B9 folic acid, B3

Nicotinic acid and B5 pantothenic acid.

Vitamin C is a radical scavenger and has an antioxidant effect, it is an important coenzyme for an enzyme in the biosynthesis of the protein collagen. In addition, it converts proline residues into hydroxyproline, which is responsible for the stable

Collagen construction is essential. Vitamin C is an important cofactor in the hydroxylation of steroids, and it plays an important role in the construction of amino acids such as L-tyrosine. It is also in the conversion of dopamine to norepinephrine, cholesterol metabolism and in the

Carnitine biosynthesis necessary. With niacin and vitamin B6, vitamin C controls the production of L-carnitine, which is needed for fat burning in the muscles. In addition, it promotes the absorption of iron in the small intestine.

Magnesium is indispensable for all organisms. It is involved in about 300 enzyme reactions as an enzyme constituent or coenzyme. Magnesium ions act as second messengers in the immune system. Magnesium deficiency also causes headache, lack of concentration, tiredness, general weakness, cardiac arrhythmias and muscle spasms. Slight deficiency can occur in competitive sports. So far, it is known how the individual substances mentioned work for themselves. So far However, it is not yet known that the combination of the substances mentioned the most common complaints of fatigue, lack of concentration,

Withdrawal symptoms, headaches and colds, and in particular performance degradation, hangover and fatigue are quickly eliminated.

Vitamin B2, Vitamin B12, Vitamin B3, Magnesium, Coenzyme Q10, Tryptophan are necessary substances that activate mitochondrial metabolism. For example, Does the respiratory chain have 3 out of 5 reactions involving Q10?

Without magnesium, ATP can not be formed. Carnitine is at the

Mitochondrial membrane necessary for stabilization and fats can be introduced into the mitochondrion only with the help of carnitine, therefore improved energy metabolism.

Galactose is introduced into the metabolism as an immediate carbohydrate, insulin independent.

Vitamin C also acts as an antioxidant at all levels.

Since the brain has few protective factors, it is protected from oxidative processes by Q10, vitamin C.

According to the invention, the composition may additionally comprise inositol. Inositol is important in signaling within the cells. For example, signals that reach the cell from the outside are directed from the cell membrane into the cell nucleus with the help of inositol as a second messenger, thus adapting the cell's metabolism to external requirements.

According to the invention, the composition may also comprise DMAE (dimethylaminoethanol). DMAE is a nootropic substance that improves brain function, especially memory impairment, lack of concentration, lack of drive and increased fatigue.

In addition, the composition may contain isomaltose. Isomaltose is a sugar whose glycemic activity is very low and, after conversion, provides glucose to the body over a longer period of time. The blood sugar level remains stable and thus the body is the result of this Energy over a longer period of time, which is important for the physical and mental performance.

Further, a flavor neutralizer (e.g., Resolver® from Wild) can be used to taste-neutralize bitter substances.

The composition is well suited for the preparation of a dietary supplement, in solid as well as liquid or powder form. The corresponding dietary supplement containing the combination according to the invention is suitable for use in the treatment of fatigue,

Lack of concentration, withdrawal symptoms, headaches and

Colds and in particular of performance decline, hangover and fatigue.

In a particularly preferred embodiment, the individual components of the composition are present in the following molar ratios to one another:

Component ratio

NADH 91-121

Vitamin B2 537-716

Vitamin B3 125-166

Vitamin B12 1

Vitamin C 1912-3059

Galactose 22450-29,933

Magnesium citrate 220 - 439

Tryptophan 990-2641

Carnitine 2510 - 5020

Q10 activates 78 - 125

Inositol 877-2631

DMAE 2658-7088

A particularly preferred embodiment of the composition according to the invention comprises the following quantitative ranges of the individual components:

NADH 30 - 90 mg

Vitamin B2 100 - 300 mg Vitamin B3 50 - 150 mg (as inositol nicotinate - retarded)

Vitamin B12 500 - 2000 μg (as hydroxycobalamin)

Vitamin C 200 - 500 mg

Galactose 2 - 6 g

Magnesium citrate 100-200 mg

Tryptophan 200 - 500 mg

Carnitine 300 - 600 mg

Q10 activates 40 - 100 mg

Inositol 100-300 mg

DMAE 150 - 400 mg

As a particularly preferred dosage, the administration of the following substances with the following concentration has been found:

NADH 30 mg

Vitamin B2 200 mg

Vitamin B3 100 mg (as inositol nicotinate - has a retarded effect)

Vitamin B12 1000 μg (as hydroxycobalamin)

Vitamin C 250 mg

Galactose 8 g

Magnesium citrate 150 mg

Tryptophan 5050 mg

Carnitine 500 mg

Q10 activates 40 mg

Inositol 200 mg

DMAE 250 mg

Isomaltose 16 g

Resolver 9000 g

Most preferably, these components and amounts are dissolved in at least 30 ml of liquid, especially water, most preferably 65 ml.

Claims

claims

1 . Composition comprising NADH and D-galactose for use in

Treatment of fatigue, lack of concentration, withdrawal symptoms, headaches and colds and in particular of performance degradation, hangover and fatigue.

2. Composition according to claim 1, further comprising vitamins and / or

Coenzymes and / or minerals.

3. Composition according to claim 1 or 2, further comprising at least one or more substances selected from the group consisting of L-tryptophan, nicotinic acid or nicotinamide, vitamin B12, vitamin B2, L-carnitine, magnesium, coenzyme Q10, vitamin C, inositol, dimethylaminoethanol or precursors of the aforementioned.

4. Composition according to claim 3, characterized in that the composition contains 30 mg NADH, 200 mg vitamin B2, 100 mg vitamin B3 as inositol nicotinate, 1000 [g vitamin B12 as hydroxycobalamin, 250 mg vitamin C, 4 g galactose, 150 mg magnesium Citrate, 500mg tryptophan, 500mg carnitine, 100mg coenzyme Q10 (activated).

5. Use of a composition according to any one of the preceding claims for the preparation of a dietary supplement, in particular in liquid form.

A dietary supplement containing a combination according to any one of the preceding claims for use in the treatment of fatigue,

Lack of concentration, withdrawal symptoms, headaches and

Colds and in particular of performance decline, hangover and fatigue.