WO2015115114A1 - Système de mesure de pression sanguine et capteur d'onde d'impulsion - Google Patents

Système de mesure de pression sanguine et capteur d'onde d'impulsion Download PDF

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Publication number
WO2015115114A1
WO2015115114A1 PCT/JP2015/000432 JP2015000432W WO2015115114A1 WO 2015115114 A1 WO2015115114 A1 WO 2015115114A1 JP 2015000432 W JP2015000432 W JP 2015000432W WO 2015115114 A1 WO2015115114 A1 WO 2015115114A1
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Prior art keywords
blood pressure
pulse wave
electrode
voltage
measurement system
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PCT/JP2015/000432
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English (en)
Japanese (ja)
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正吾 中谷
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日本電気株式会社
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Priority to JP2015559832A priority Critical patent/JPWO2015115114A1/ja
Publication of WO2015115114A1 publication Critical patent/WO2015115114A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter

Definitions

  • the present invention relates to a pulse wave sensor that can be always worn on a daily basis, and a blood pressure measurement system that wears the pulse wave sensor and continuously measures blood pressure.
  • the cuff method includes a Korotrov method using Korotrov sound, an oscillometric method using pulse wave vibration, and a capacitance compensation method.
  • the apparatus since the cuff is attached to an arm or a fingertip to perform pressurization or decompression, the apparatus cannot be reduced in size, and a sense of incongruity during measurement is great. For this reason, there is a problem that it is not suitable for measuring blood pressure constantly while living daily life.
  • the Korotrov method and the oscillometric method which are widely used among the cuff methods, have a problem that only representative blood pressure indexes such as the maximum blood pressure, the minimum blood pressure, and the average blood pressure can be measured intermittently.
  • the tonometry method is known as a non-invasive method for obtaining a continuous blood pressure waveform. Examples of applying this method are disclosed in Patent Document 1 and Patent Document 2.
  • this method has a problem that the sense of discomfort is still great because the pressure sensor must be pressed against the artery with a certain pressure.
  • both the cuff method and the tonometry method are easily affected by disturbances caused by body movements. Therefore, this method is also not suitable for continuous blood pressure measurement in daily life.
  • Non-patent document 1 proposes a method for measuring the pulse wave propagation delay shown in FIG. 12 as a method for measuring blood pressure continuously to some extent with little discomfort.
  • the subject 100 is equipped with pulse wave sensors 101A and 101B.
  • Pulse wave sensors 101A and 101B are attached to places where the arrival times of pulse waves are different, for example, wrists and ankles, and measure pulse waves at the respective places. Or you may make it use the electrocardiogram sensor 102 attached to the chest and one pulse wave sensor, for example, one of the pulse wave sensors 101A or 101B.
  • FIG. 13 shows an example of an electrocardiogram (Electrocardiogram, ECG) measured by the electrocardiographic sensor 102 and an example of a pulse wave signal (Photoplethysmography, PPG) measured by the pulse wave sensor 101A or 101B.
  • t is time.
  • Non-Patent Document 1 discloses a method for calculating a blood pressure (Blood pressure, P) based on the time difference T between the ECG peak time and the PPG rise time. As the time difference T, a pulse wave arrival time difference between the two pulse wave sensors 101A and 101B may be used.
  • FIG. 14 is a diagram for explaining the principle of this photoelectric pulse wave sensor.
  • the photoelectric pulse wave sensor emits infrared irradiation light 40 toward the artery 20 in the body from the light source 30 attached to the skin surface 16, and receives the reflected light 41 reflected by the blood 23 in the artery 20 as a light receiver 31. And measuring the change in the intensity of the reflected light 41.
  • the pulse wave can be measured by utilizing the fact that the intensity of the reflected light 41 changes according to the pulse wave. Since this photoelectric pulse wave sensor is relatively small, there is an advantage that there is little uncomfortable feeling at the time of wearing. Further, since the pulse wave propagation delay is used, it is only necessary to know the time of the pulse wave peak or rise, and there is an advantage that it is not affected by a slight fluctuation in the wave height.
  • the blood pressure measurement method based on the pulse wave propagation delay time using the photoelectric pulse wave sensor disclosed in Patent Document 3 has the following problems. That is, since the photoelectric pulse wave sensor uses a light source such as an LED (Light Emitting Diode), there is a problem that power consumption is large and frequent replacement and charging of the battery are required. Moreover, since only one blood pressure value can be obtained for each heartbeat, there is a problem that a continuous blood pressure waveform cannot be obtained.
  • a light source such as an LED (Light Emitting Diode)
  • the present invention has been made in view of the above-described problems, and an object thereof is to realize continuous blood pressure measurement with reduced discomfort in daily life and low power consumption.
  • a blood pressure measurement system includes: a pulse wave detection unit that detects in time series a voltage of an electromotive force generated by a blood flow of a subject crossing a magnetic field line; and a processing unit that calculates a blood pressure based on the voltage.
  • the pulse wave detection means includes a permanent magnet that generates the lines of magnetic force, and an electrode that detects the voltage.
  • the pulse wave sensor according to the present invention includes a permanent magnet that generates a line of magnetic force and an electrode that detects a voltage of an electromotive force generated by a blood flow across the line of magnetic force.
  • FIG. 1 is a block diagram illustrating a configuration of a blood pressure measurement system according to a first embodiment of the present invention. It is a block diagram which shows the structure of the blood pressure measurement system of the 2nd Embodiment of this invention. It is a perspective view which shows the example which equips a subject with the pulse-wave detection means of the 2nd Embodiment of this invention. It is a figure which shows the cross-section of the pulse-wave detection means of the 2nd Embodiment of this invention. It is a block diagram which shows the structure of the circuit part of the pulse-wave detection means of the 2nd Embodiment of this invention. It is a figure which shows the structure seen from the sensor part of the pulse-wave detection means of the 2nd Embodiment of this invention.
  • ECG electrocardiogram signal
  • PPG pulse wave signal
  • FIG. 1 is a diagram showing a configuration of a blood pressure measurement system according to a first embodiment of the present invention.
  • the blood pressure measurement system 1 includes: a pulse wave detection unit 2 that detects in time series a voltage of an electromotive force generated by a blood flow of a subject crossing a magnetic field line; and a processing unit 3 that calculates a blood pressure based on the voltage.
  • the pulse wave detecting means 2 includes a permanent magnet that generates the magnetic lines of force, and an electrode that detects the voltage.
  • FIG. 2 is a diagram showing a configuration of a blood pressure measurement system according to the second embodiment of the present invention.
  • the blood pressure measurement system 1 includes a pulse wave detection unit 2 that is a pulse wave sensor, and a processing unit 3 that calculates blood pressure based on the pulse wave.
  • the pulse wave detection means 2 includes a sensor unit 4 that detects a pulse wave by detecting in time series a voltage generated by the blood flow of the subject crossing the magnetic field lines. Furthermore, a circuit unit 5 that uses the voltage detected by the sensor unit 4 as time-series digital data and a communication unit 6 that transmits the digital data obtained by the circuit unit 5 to the processing means 3 are provided. The transmission can be performed wirelessly.
  • the processing unit 3 includes a communication unit 9 that receives the digital data transmitted from the communication unit 6 of the pulse wave detection unit 2. Furthermore, in order to perform calibration when calculating blood pressure from the digital data, a storage unit 7 that stores a blood pressure value of a subject obtained by another method in advance, and an input unit that inputs the blood pressure value and the like 10. Furthermore, a calculation unit 8 that calculates a continuous blood pressure waveform that is time-series data of blood pressure based on the digital data and the blood pressure value, and a display unit 11 that displays the calculation result are provided.
  • a server device can be used as the processing means 3.
  • the calculation unit 8 can be realized by the calculation function of the central processing unit (CPU) of the server device.
  • the storage unit 7 by a storage function such as a memory of the server device, the communication unit 9 by a communication function such as wireless communication, the input unit 10 by an input function such as a keyboard, the display unit 11 by a display function such as a display, Each can be realized.
  • the processing means 3 can also use a mobile terminal such as a smartphone. By using the processing means 3 as a portable terminal, blood pressure can be continuously measured even when the subject moves.
  • FIG. 3 is a perspective view showing an example in which the pulse wave detecting means 2 which is a pulse wave sensor of the present embodiment is attached to a subject.
  • the pulse wave detecting means 2 is attached by a method such as sticking on the skin surface of the arm 12 of the subject.
  • An artery passes under the pulse wave detection means 2, and blood flows in the blood flow direction 25, that is, in the direction from the heart to the hand 13.
  • FIG. 4 is a cross-sectional view taken along the cross section 14 of the body of the pulse wave detecting means 2 in FIG.
  • the pulse wave detecting means 2 includes a sensor unit 4 having a permanent magnet 50, an electrode 61 and an electrode 62 disposed on the skin surface 16, a circuit unit 5 connected to the electrode 61 and the electrode 62 by a wiring 71 and a wiring 72, A communication unit 6 is included.
  • the permanent magnet 50 generates lines of magnetic force 55 when, for example, the lower surface facing the skin surface 16 is an N pole and the upper surface is an S pole.
  • the artery 20 passes under the permanent magnet 50, and in this case, the blood 23 flows from the back of the page toward the front. Since the blood 23 is an electric conductor, an electromotive force known as Fleming's law is generated in the blood 23 by flowing across the magnetic field lines 55. For this reason, a voltage is generated between the left and right blood vessel walls 21 and the blood vessel wall 22 of the artery 20. This voltage can be detected by the electrode 61 and the electrode 62. Since this voltage is proportional to the blood flow velocity V, time series data corresponding to the blood flow velocity can be obtained by measuring this voltage in time series.
  • FIG. 5 is a diagram illustrating a configuration of the circuit unit 5.
  • the circuit unit 5 includes an amplifying unit 17 for amplifying the voltage, a filter unit 18 for removing noise from the voltage, and analog-to-digital conversion (analog-to-digital converter, abbreviated as ADC) of the voltage for time-series digital processing. And an ADC unit 19 for data d (t) (t is time).
  • ADC analog-to-digital converter
  • FIG. 6 is a view of the sensor unit 4 as viewed from the lower side of FIG.
  • a line of magnetic force 55 emerging from the north pole of the permanent magnet 50 penetrates the blood 23 in the artery 20 toward the front of the page.
  • a voltage is generated in a direction perpendicular to the direction of the lines of magnetic force 55 and the blood flow direction 25, and is detected by the electrodes 61 and 62.
  • the detected voltage is converted into digital data d (t) by the circuit unit 5 and sent to the calculation unit 8 via the communication unit 6 and the communication unit 9.
  • V (t) u ⁇ d (t) (equation 1) using the proportionality constant u. It can be expressed as.
  • the blood pressure P (t) can be obtained from the digital data d (t) by using Equation 1 and a relational expression between the blood flow velocity V (t) and the blood pressure P (t).
  • the digital data d (t) is data at discrete sampling times, and the blood pressure P (t) obtained from this is also time-series data at the discrete sampling times.
  • a continuous waveform as shown in FIGS. 7A and 7B can be approximated with sufficient accuracy. Solving differential equations numerically requires high computing power and a lot of power consumption. For this reason, it is desirable that the processing means 3 calculates the blood pressure P (t) from the digital data d (t).
  • the parameters u, r, and C included in Equation 1 and Equation 2 match the blood pressure value calculated by this embodiment with the blood pressure value of the subject obtained in advance by another method such as the cuff method or the tonometry method. Determine as follows. This process is called calibration. Blood pressure measurement devices such as the cuff method and tonometry method used for calibration are not portable, but once calibrated, the parameters obtained can be used for a while. For example, calibration can be performed at a clinic, hospital, or home, and using the parameters obtained there, continuous measurement of blood pressure for several days can be performed while sending a daily life according to this embodiment.
  • FIG. 8 shows a flowchart of blood pressure calculation according to the present embodiment.
  • step S101 the parameters u, r, and C included in Equation 1 and Equation 2 are calibrated.
  • the blood pressure value of the subject is measured in advance by another method such as the cuff method, and the measured blood pressure value is input from the input unit 10 and stored in the storage unit 7.
  • the pulse wave detection means 2 detects time-series data of the voltage corresponding to the pulse wave of the same subject.
  • the detected time-series data of the voltage is converted into digital data d (t) by the circuit unit 5 and sent to the calculation unit 8 via the communication unit 6 and the communication unit 9.
  • Parameters u, r, and C are determined from the digital data d (t) so that the blood pressure value obtained by Equation 1 and Equation 2 matches the blood pressure value obtained in advance by the cuff method, for example.
  • the parameters determined as described above are stored in the storage unit 7 and are used when calculating blood pressure values in subsequent steps.
  • the measurement by the pulse wave detection means 2 and the measurement by another method such as the cuff method be performed under the same conditions in the shortest possible time. Further, in order to increase the accuracy of calibration, it is desirable to perform measurement and result matching by both methods a plurality of times. In order to perform measurement with high accuracy, it is desirable to perform measurement without moving the body in a hospital, clinic, home, or the like.
  • step S102 the pulse wave detection means 2 acquires time series data of the voltage corresponding to the pulse wave.
  • the time-series data at this time can be time-series data obtained by acquiring a plurality of voltages in a time series in one heartbeat. Further, the time series data can be a plurality of heartbeats. After this step, it can be performed while sending a normal daily life. Note that the pulse wave detection means 2 after step S102 needs to maintain the mounting state in step S101. This is because the parameter u in Equation 1 varies depending on the mounting state of the pulse wave detection means 2.
  • step S103 the voltage data acquired in step S102 is converted into digital data d (t) by the circuit unit 5 and transmitted to the processing means 3.
  • the transmission from the communication unit 6 to the communication unit 9 is preferably wireless communication so that there is no sense of incongruity in daily life. Also, it is desirable to transmit a certain amount of data collectively to reduce power consumption during transmission. For example, it is desirable to transmit the data for each heartbeat collectively.
  • step S104 blood pressure for one heartbeat is calculated from the digital data d (t) of the voltage data transmitted in step S103, the parameters u, r, and C determined in step S101, and equations 1 and 2. .
  • the procedure for calculating the blood pressure is performed by solving Equation 2, that is, integrating.
  • the blood flow velocity V (t) based on the digital data d (t) is included in the integrand.
  • a low-noise blood pressure value can be obtained by calculating blood pressure by such a method.
  • step S105 it is determined whether or not the sensing by the pulse wave detection means 2 is to be terminated. This determination is made based on, for example, whether or not the processing means has shifted to an operation for ending the processing. If the process ends (YES), the flowchart ends. If not finished (NO), step S102 and subsequent steps are repeated. As described above, the blood pressure is continuously calculated.
  • the pulse wave detection means 2 which is a pulse wave sensor of the present embodiment is an electromagnetic pulse wave sensor using a permanent magnet, and thus has low power consumption. For example, it does not have a light source that requires power consumption like the photoelectric pulse wave sensor of FIG. Therefore, even a small battery can continue to operate for a sufficiently long period.
  • the electromagnetic pulse wave sensor since the electromagnetic pulse wave sensor has a simple structure, it can be easily downsized. Therefore, since it is only necessary to attach a small electromagnetic pulse wave sensor to the skin surface, it is possible to live daily life without a sense of incongruity.
  • a continuous blood pressure waveform that is, a plurality of blood pressure values within one heartbeat can be obtained. It acquires pulse wave data corresponding to a plurality of blood flow velocities within one heartbeat by an electromagnetic pulse wave sensor, and uses a relational expression between blood flow velocity and blood pressure based on this data to perform a plurality of samplings within one heartbeat. This is because a continuous blood pressure waveform corresponding to the point can be obtained.
  • the blood pressure can be calculated with only one electromagnetic pulse wave sensor.
  • FIG. 9 is a diagram showing a cross-sectional structure of the sensor portion 4 ′ of the pulse wave detection means 2 that is a pulse wave sensor according to the third embodiment of the present invention.
  • a cross section 15 of the body in FIG. 9 is a cross section perpendicular to the cross section 14 of the body in FIG.
  • the permanent magnet 50 ′ disposed on the skin surface 16 has a horseshoe shape.
  • Magnetic field lines 55 ′ are generated from the north pole of the permanent magnet 50 ′ toward the south pole. Immediately below the north pole, the magnetic field lines 55 'penetrate the blood 23 from top to bottom, and below the south pole, the blood 23 penetrates from bottom to top. Since the blood flow directions 25 under the N pole and under the S pole are the same, the voltage generated in the vicinity of the N pole and the polarity of the voltage generated in the vicinity of the S pole are opposite to each other according to Fleming's law.
  • FIG. 10 shows a bottom view of the structure of FIG. 9 viewed from below.
  • the magnetic field lines 55N immediately below the magnetic pole 51, which is the N pole penetrate the blood 23 in the front direction of the drawing, and the magnetic lines 55S immediately below the magnetic pole 52, which is the S pole, penetrate the blood 23 toward the back of the drawing.
  • the polarity of the voltage generated between the electrode 62 ′ and the electrode 61 is opposite to the polarity of the voltage generated between the electrode 62 ′ and the electrode 63.
  • the electrode 62 ′ is shared by the magnetic pole 51 and the magnetic pole 52. Therefore, voltages having opposite polarities are generated in the electrode 61 and the electrode 63 with respect to the electrode 62 '.
  • Biosignals are susceptible to so-called hum noise from commercial AC power supplies.
  • in-phase noise such as hum noise, that is, noise added in phase to both the positive input and the negative input of the instrumentation amplifier can be removed.
  • the pulse wave detecting means having the sensor unit 4 'of the present embodiment can be used as the pulse wave detecting means 2 of the blood measurement system shown in FIG.
  • the pulse wave detection means having the sensor unit 4 ′ of the present embodiment can measure blood pressure on a daily basis by sticking to the arm 12 of the subject.
  • the direction of the arrangement of the magnetic poles of the permanent magnet 50 ' that is, the direction of the lines of magnetic force 55 may be opposite.
  • the blood measurement system and the pulse wave sensor of the second or third embodiment are combined with a method for measuring a pulse wave transmission delay. That is, as shown in FIG. 12, the pulse wave transmission delay is measured by one electrocardiographic sensor 102 and one pulse wave sensor 101A, or two pulse wave sensors 101A and 101B, and thereby the blood pressure value is calculated for each heartbeat. calculate. Using this blood pressure value, the blood pressure value calculated by the blood measurement system of the second embodiment or the third embodiment is calibrated for each heartbeat.
  • FIG. 11 shows a flowchart of blood pressure calculation according to the present embodiment.
  • the first and second electromagnetic pulse wave sensors are used will be described, but one of the electromagnetic pulse wave sensors may be an electrocardiographic sensor.
  • step S201 the parameters u, r, and C included in Equation 1 and Equation 2 are calibrated. This step is the same as step S101 in the flowchart of FIG.
  • step S202 the first electromagnetic pulse wave sensor (pulse wave detecting means 2) acquires time series data of a voltage corresponding to the pulse wave. Further, the acquired voltage data is converted into digital data d (t) by the circuit unit 5 and transmitted to the processing means 3.
  • the process of step S202 is the same as the process of step S102 and step S103 of FIG. Note that the pulse wave arrival time at the first electromagnetic pulse wave sensor is obtained from the time-series data of the voltage corresponding to the pulse wave using the calculation function of the calculation unit 8 of the processing means 3.
  • the second electromagnetic pulse wave sensor (pulse wave detection means 2) acquires time series data of a voltage corresponding to the pulse wave. This is transmitted to the processing means 3, and the pulse wave arrival time at the second electromagnetic pulse wave sensor is obtained using the calculation function of the calculation unit 8 of the processing means 3.
  • the pulse wave arrival time here can also be obtained using an electrocardiographic sensor instead of the second electromagnetic pulse wave sensor.
  • step S204 the processing means 3 calculates pulse wave transmission delays in the first and second electromagnetic pulse wave sensors, and calculates a blood pressure value based on the delay.
  • the method of Non-Patent Document 1 can be used.
  • step S205 blood pressure for one heartbeat is calculated from the digital data d (t) of the voltage data transmitted in step S202, the parameters u, r, and C determined in step S201, and equations 1 and 2. .
  • the process of step S205 is the same as the process of step S104 of FIG.
  • step S206 the blood pressure data is calibrated for each heartbeat so that the blood pressure value obtained in step S204 matches the blood pressure data obtained in step S205.
  • the blood pressure data obtained in step S205 is obtained so that the highest blood pressure for each heart beat is obtained in step S204, and the highest blood pressure obtained from the blood pressure data for each heart beat obtained in step S205 matches the highest blood pressure obtained in step S204. Is multiplied by a constant.
  • step S207 it is determined whether or not to end sensing. This determination is made based on, for example, whether or not the processing means 3 has shifted to an operation for ending the processing. If the process ends (YES), the flowchart ends. If not finished (NO), step S202 and subsequent steps are repeated. As described above, the blood pressure is continuously calculated.
  • the blood pressure value is calibrated for each heartbeat, it is affected by fluctuations in the acquired data in the electromagnetic pulse wave sensor due to body movement, sweating, etc., specifically, fluctuations in the constant u in Equation 1. There is an advantage that it is difficult.
  • Appendix 1 A pulse wave detection means for detecting in time series a voltage of an electromotive force generated by a blood flow of a subject crossing a magnetic field line; and a processing means for calculating a blood pressure based on the voltage, the pulse wave detection means
  • a blood pressure measurement system comprising: a permanent magnet that generates the lines of magnetic force; and an electrode that detects the voltage.
  • the permanent magnet has an N pole and an S pole disposed on the skin surface of the subject,
  • the electrode is A common electrode for the N pole side and the S pole side, which serves as a reference potential for the electromotive force generated respectively on the N pole side and the S pole side;
  • a first electrode for detecting a first potential of the electromotive force generated on the N pole side with respect to the common electrode, and the polarity generated on the S pole side having a polarity opposite to the first potential
  • a second electrode for detecting a second potential of the electromotive force,
  • the blood pressure measurement system according to appendix 1, wherein the voltage is detected by the reference potential, the first potential, and the second potential.
  • the blood pressure measurement system according to claim 1, wherein the processing means calculates a blood flow velocity based on the voltage, and calculates the blood pressure by solving a differential equation including the blood flow velocity.
  • Appendix 8 The blood pressure measurement system according to appendix 7, wherein the processing unit calibrates the parameters for calculating the blood flow velocity and the blood pressure based on a blood pressure obtained in advance.
  • Appendix 9 The blood pressure measurement system according to appendix 8, wherein the processing means performs the calibration using a blood pressure obtained in advance by a cuff method or a tonometry method. (Appendix 10) 10.
  • a pulse wave sensor comprising: a permanent magnet that generates magnetic lines of force; and an electrode that detects a voltage of an electromotive force generated by a blood flow crossing the magnetic lines of force.
  • the permanent magnet has an N pole and an S pole disposed on the skin surface of the subject,
  • the electrode is A common electrode for the N pole side and the S pole side, which serves as a reference potential for the electromotive force generated respectively on the N pole side and the S pole side;
  • a first electrode for detecting a first potential due to the electromotive force generated on the N pole side with respect to the common electrode, and the polarity generated on the S pole side having a polarity opposite to the first potential
  • a second electrode for detecting a second potential due to an electromotive force,
  • the pulse wave sensor according to appendix 11, wherein the voltage is detected by the reference potential and the first and second potentials.
  • the present invention is applicable to a pulse wave sensor that can be always worn on a daily basis, and a blood pressure measurement system that wears this pulse wave sensor to continuously measure blood pressure.

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Abstract

Pour permettre la réalisation d'une mesure de pression sanguine continue présentant une gêne réduite pendant des activités quotidiennes et une faible consommation d'énergie, le système de mesure de pression sanguine comprend : un moyen de détection d'onde d'impulsion pour détecter une tension d'une force électromotrice dans des séries chronologiques, qui provient d'une circulation sanguine d'un sujet coupant des lignes de force magnétique ; et un moyen de traitement pour calculer une pression sanguine sur la base de la tension. Le moyen de détection d'onde d'impulsion comprend en outre un aimant permanent qui émet les lignes de force magnétique, et des électrodes qui détectent la tension.
PCT/JP2015/000432 2014-02-03 2015-02-02 Système de mesure de pression sanguine et capteur d'onde d'impulsion WO2015115114A1 (fr)

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EP3275365A1 (fr) * 2016-07-27 2018-01-31 Cerasani, Ennio Système d'évaluation de la circulation artérielle interactive non invasive
WO2020104945A1 (fr) * 2018-11-20 2020-05-28 42 Health Sensor Holdings, Ltd. Dispositif de surveillance cardiovasculaire extracorporel
WO2020171948A1 (fr) * 2019-02-20 2020-08-27 Edwards Lifesciences Corporation Dispositif de mesure continue et non invasive de la tension artérielle
EP4299000A1 (fr) * 2022-06-30 2024-01-03 CERAGOS Electronics & Nature Procédé d'évaluation de la circulation artérielle basé sur des ultrasons portatifs

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US11344209B2 (en) 2018-11-13 2022-05-31 Samsung Electronics Co., Ltd. Electronic device and method of estimating bio-information using the same

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