WO2015112468A1

WO2015112468A1 - Hydrogen peroxide use in ap/do

Info

Publication number: WO2015112468A1
Application number: PCT/US2015/011949
Authority: WO
Inventors: Heng Cai; Vijay Joshi
Original assignee: Revlon Consumer Products Corporation
Priority date: 2014-01-22
Filing date: 2015-01-20
Publication date: 2015-07-30

Abstract

The present invention is directed to an antiperspirant composition, comprising: (a) a carrier material; (b) an antiperspirant active in an amount from about 5% to less than 25%, by weight of the composition on an anhydrous basis; (c) a plurality of particles comprising a silica complexed with hydrogen peroxide and the silica hydrogen peroxide particles release oxygen when exposed to perspiration.

Description

HYDROGEN PEROXIDE USE IN AP/DO

FIELD OF INVENTION

[0001] The present invention relates to incorporation of hydrogen peroxide in a nonaqueous antiperspirant composition.

[0002] BACKGROUND OF THE INVENTION

[Θ003] It is difficult to deliver the benefits associated with hydrogen peroxide in antiperspirant products. Hydrogen peroxide being a strong oxidant can react with the fragrance component of antiperspirants creating a malodor. Rapid decomposition into oxygen also occurs after reacting with any of the basic components of an antiperspirant formula, it is difficult to improve the delivery efficiencies of hydrogen peroxide in an antiperspirant formulation as hydrogen peroxide breaks down to water and released oxygen prior to use by the consumer.

[0004] Accordingly, there is a need for a hydrogen peroxide containing delivery particles that provide the benefits associated with free oxygen delivery over time.

[0005] SUMMARY OF THE INVENTION

[0006] The present invention is directed to an antiperspirant composition, comprising: (a) a carrier material; (b) an antiperspirant active in an amount from about 5% to less than 25%, by weight of the composition on an anhydrous basis; (c) a plurality of particles comprising a silica complexed with hydrogen peroxide and the silica hydrogen peroxide particles release oxygen when exposed to perspiration.

[0007] In an embodiment the antiperspirant active is included in an amount from about 10% to less than or equal to about 20%, by weight of the composition on an anhydrous basis.

[0008] In an embodiment the percent of the silica that is complexed with the hydrogen peroxide is about 5% to about 30%. In another embodiment the percent of the silica that is complexed with the hydrogen peroxide is about 25%. The silica may be hydrophobic a hydrated silica, a silica silyiate, or a silica silylate dtmethicone. [0009] In an embodiment the percent of the hydrogen peroxide that is complexed with the silica is about 5% to about 30%. In another embodiment the percent of the silica that is complexed with the hydrogen peroxide is about 20%.

[0010] In an embodiment the silica complexed with the hydrogen peroxide is configured to be timed released in an environment having a pH range of at least 5.4 to 6.4.

[0011] In an embodiment the silica hydrogen peroxide complex comprise about 0.05 to about 8 wt. % of the antiperspirant composition.

[0012] In an embodiment the antiperspirant composition is in a form selected from the group consisting of solid and soft solid.

[0013] In an embodiment the antiperspirant or deodorant compositions, are merchandised by communicating a comparison to perspective buyers between a first antiperspirant deodorant composition comprising a silica hydrogen peroxide complexes and a second antiperspirant/deodorant composition that comprises hydrogen peroxide without silica and a third antiperspirant/deodorant composition with no hydrogen peroxide. The comparison comprises a performance comparison of oxygen release.

10014] BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 is a photo of a conical flask {to show the set up) containing antiperspirant composition with artificial sweat fitted with a balloon.

[0016] Figure 2 is a photo of the closed flask containing antiperspirant composition with artificial sweat taken at time zero,

[0017] Figure 3 is a photo of the closed flask containing antiperspirant composition with artificial sweat taken at 10 minutes.

[0018] Figure 4 is a photo of the closed flask containing antiperspirant composition with artificial sweat taken at 1 hour.

[0019] Figure 5 is a photo of the closed flask containing antiperspirant composition with artificial sweat taken at 3.5 hours.

[0020] Figure 6 is a photo of the closed flask containing antiperspirant composition with artificial sweat taken at 6 hours.

P T/US2015/011949

DETAILED DESCRIPTION OF THE INVENTION

[0021] The present invention is directed to an antiperspirant composition, comprising: (a) a carrier material; (b) an antiperspirant active in an amount from about 5% to less than 25%, by weight of the composition on an anhydrous basis; (c) a plurality of particles comprising a silica complexed with hydrogen peroxide and the silica hydrogen peroxide particles release oxygen when exposed to perspiration.

[0022] The terms used in this specification generally have their ordinary meanings in the art, within the context of the invention, and in the specific context where each term is used. Certain terms are discussed below, or elsewhere in the specification, to provide additional guidance to the practitioner in describing the compounds, compositions, and methods of the invention and how to make and use them. Moreover, it will be appreciated that the same thing can be said in more than one way. Consequently, alternative language and synonyms may be used for any one or more of the terms discussed herein, nor is any special significance to be placed upon whether or not a term is elaborated or discussed herein. The use of examples anywhere in this specification, including examples of any terms discussed herein, is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term, Likewise, the invention is not limited to the examples presented.

[0023] In addition to the silica hydrogen peroxide complex of the present invention, the cosmetic compositions of the present invention include a carrier material. The carrier material for use in formulating the cosmetic compositions may comprise one or more compounds which is selected based on the particular intended use of the composition. The carrier may be inorganic or organic in nature; it must be non-toxic and non-irritating. The carrier must also be compatible with a plurality of particles comprising a silica complexed with hydrogen peroxide.

[0024] The cosmetic compositions of the present invention may also include one or more optional ingredients. Examples of the optional ingredients include but are not limited to lubricants, preservatives, perfumes, and colorants, oils, and waxes. The optional ingredients should be chemically inert with respect to each other, and with respect to the silica hydrogen peroxide particles. [0025] Lists of carrier materia! and optional ingredients, which are well known in the art, are disclosed, for example, in "Cosmetics: Science and Technology," edited by M. S. Balsam and E. Sagarin, 2nd Edition, 1972, Wiley Pub. Co.; "The Chemistry and Manufacture of Cosmetics" by . G. DeNavasse; and "Harry's Cosmeticology," J. B. Wilkinson et al., 7th Edition, 1982, Chem. Pub. Co.; the disclosures of each of the above being incorporated herein by reference.

[0026] As used herein, "about" or "approximately" generally means within 20 percent, preferably within 10 percent, and more preferably within 5 percent of a given value or range.

[0027] As used herein, the silica is preferably hydrophobically modified silica. Examples of various types of silicas that may be used herein include, but are not limited to fumed silica, hydrated silica, silica silylate, or silica silylate dimethicone.

[0028] As used herein the antiperspirant contains an active ingredient intended to reduce the negative effects of odor and wetness associated with perspiration. The antiperspirant active compositions are present in a concentration of 5% to less than 25%, by weight of the composition on an anhydrous basis and means any compound or composition having antiperspirant activity, preferably astringent metallic salts such as the inorganic and organic salts of aluminum, zirconium, and zinc, and mixtures thereof. Particularly preferred are the aluminum and zirconium salts such as aluminum halides, aluminum hydroxide halides, zirconyl oxide halides, zirconyl hydroxy halides, and mixtures thereof.

[0029] Examples of aluminum and zirconium salts include aluminum chloride, aluminum chlorohydrate, aluminum chlorohydrex PEG, aluminum chlorohydrex PG, aluminum dichlorohydrate, aluminum dich!orohydrex PEG, aluminum dich!orohydrex PC, aluminum sesquichlorohydrate, aluminum sesquichlorohydrex PEG, aluminum sesquichlorohydrex PG, aluminum zirconium octachlorohydrate, aluminum zirconium octachloroydrex GLY, aluminum zirconium pentachlorohydrate, aluminum zirconium pentachlorohydrex GLY, aluminum zirconium tetrachlorohydrate, aluminum zirconium tetrachlororhydrex GLY, aluminum zirconium trichlorohydrate, aluminum zirconium trichlorohydrex GLY, and mixtures thereof. [0030] it may be desired to incorporate into the antiperspirant composition one or more deodorant actives instead of the antiperspirant actives. The deodorant actives should be soluble in the aqueous single phase composition, or water dispersible carrier, such as triclosan encapsulated in cyclodextrin, which may be purchased from Lipo, Inc. Examples of suitable deodorant actives include fragrances, ammonium phenolsulfonate, benzalkonium chloride, benzethonium chloride, bromochlorophene, cetylpyridinium chloride, chlorophyllin-copper complex, chlorothymo!, chloroxylenol, cloflucarban, dequalinium chloride, dichlorophene, dichloro-m-xylenol, disodium dihydroxyethyl suifosuccinylundecylenate, domiphen bromide, hexachlorophene, lauryi pyridinium chloride, methylbenzethonium chloride, phenol, , sodium bicarbonate, sodium phenolsulfonate, triclocarbone, triclosan, zinc phenolsulfonate, zinc ricinoleate, and mixtures thereof.

[0031] The plurality of particles comprising silica complexed with hydrogen peroxide. A non-limiting example of how these particles are used may be an aqueous solution of hydrogen peroxide impregnated into the silica. The solution is applied to human skin. Oxygen is released from the plurality of particles when the composition is applied to human sweat (pH about 5.4 to 6.0).

[0032] As used herein merchandising is used as a term of art in the marketing of a product for sale.

[0033] EXAMPLES OF ANTIPERSPIRANT COMPOSITIONS

[0034] Encapsulated Hydrogen Peroxide - An aqueous solution of hydrogen peroxide was complexed in silica to form a plurality of particles by mixing the ingredients in Table 1 in an osterizer, 12 speed blender until no uncomplexed silica is present in the solution. Table 1

[0035] An antiperspirant stick including the plurality of particles was prepared as follows:

Table 2

%

Serial # CTFA Name A B

1 Cyclopentasiloxane q.s q.s

2 PPG-14 Butyl Ether 16.0 16.0 3 Tocopheryl Acetate 0.1 0.1

4 Steary! Alcohol 16.0 16.0

5 Hydrogenated Caster Oil 1.0 1.0

6 PEG-8 Distearate 1.0 1.0

7 Aluminum Zirconium 25,5 25.5

Tetrachlorohydrex Gly

8 Talc 5.0 5.0

9 Aloe Barbadensis Leaf 0.1 0.1

extrac

10 Hydrogen peroxide (35%) 0.03 0.0

11 H₂0₂ particles from 0.0 0.15 Tablel 36] An antiperspirant solid including the plurality of particles was prepared as foliows:

Table 3

[0037] An antiperspirant soft solid including the plurality of particles was prepared as follows:

Table 4

%

Serial # CTFA Name A B

1 Cyclopentasiloxane q.s q.s

2 Aluminum Zirconium 25.50 25.5

Tetrachlorohydrex Gly

3 Trisiloxane .Dimethicone 5.5 5.5

4 Tocopheryl Acetate 0.1 0.1

5 Cyclopentasiloxane 10.48 10.48

6 Petrolatum 2.0 2.0 7 AloeBarbadensis A!oe 0.01 0.01

Extrac.

8 Tribehenin 5.0 5.0

9 C 18-36 Acid triglyceride 2.0 2.0

10 Hydrogen peroxide (35%) 0.03 0.0

11 H₂0₂ particles from Table 0.0 0.15

1

[0038] Testing for release of oxygen over time:

[0039] Qualitative evolution of oxygen from an antiperspirant composition was observed by the mixing of one of the above compositions with artificial sweat. Artificial sweat was prepared by dissolving 5 g of sodium chloride, 1 gm of urea, and 1 g of lactic acid 1 L of water and adjusting the pH of the solution 6.0 to 6.4 using 10% solution of ammonium hydroxide or 20% solution of citric acid. 20 gm of the product was mixed with 20 gm of sweat solution in a conical flask fitted with a balloon as shown in Figure 1 and 2. The contents of the balloon covered flask were stirred using a magnetic stir bar while warming the flask to about 45°C. The inflated balloon suggests the release of oxygen from the plurality of particles, in further experiments use of oxygen gas monitor will confirm the findings.

[0040] The antiperspirant compositions were stored in glass jars at 50°C for five weeks.

The compositions were taken out after 1 and 5 weeks of storage. Samples were prepared from the prior tables 2 - 6. The samples were tested for the evolution of oxygen by the test method described above. The results for the evolution of oxygen are found in Table 8. A yes indicates the balloon was observed as inflated indicative of a gas released from the composition containing hydrogen peroxide complexed with silica over time, A no indicates that no gas was released over from the composition containing hydrogen peroxide at that time. The reason for a no might be that all the hydrogen peroxide was released from the silica or that no silica hydrogen peroxide complex was present in the sample (control and example 6). The control was a solution with no hydrogen peroxide or silica present. These results show that hydrogen peroxide in a non-aqueous antiperspirant composition when complexed with silica is stable and releases a gas over time when exposed to perspiration. T/US2015/011949

Table 8 Presence of oxygen

Each inflated balloon was carefully removed from the flask and attached to the oxygen gas monitor. Once again no change on the monitor dial suggests that either there was no oxygen evolved or monitor is not sensitive enough to measure the small amount of oxygen evolved.

[0041] Experiment showing release of oxygen over time:

[0042] To a conical flask were added 0.61 gms of a soft solid containing a plurality of particles comprising hydrogen peroxide comp!exed with silica dimethicone silylate, a magnetic bar, and 0.72 gms of artificial sweat. The conical flask was closed with a ground glass joint stopper fitted with a balloon (Figure 24).

[0043] The contents of the flask were mixed on a stir plate at 40°C. A photo of the closed flask was taken after 10 minutes. The balloon was deflated and continued stirring on the stir plate at 40°C. A second photo was taken after 1 hour. The balloon was deflated again and mixing was continued for an additional 3.5 hours after which another photo of the balloon was taken. The same process was repeated after 6 hours. Results are presented in Figures 2 - 6.

[0044] The results show the antiperspirant composition containing a plurality of particles comprising hydrogen peroxide comp!exed with silica releases oxygen over time until almost ail of the hydrogen peroxide is decomposed by artificial sweat, suggesting that hydrogen peroxide when comp!exed within silica dimethicone silyiate is stable and released over time.

[0045] Experiments measuring oxygen release

[0046] Encapsulated hydrogen peroxide was measured into a 0.125 mL flask for each of (1), (2), (3), and (4). [0047] (1) - Artificial sweat was added along with a stirbar to a 125 mL erienmeyer flask. The sample was closed with a joint containing a balloon. The sample was set on a hotplate to stir at room temperature.

[0048] (2) - Sodium lauryl Sulfate (30%) (SLS) and Laureth 23 (L23) were weighed into the 125 mL erienmeyer flask. Artificial sweat was added with a stirbar. The sample was closed with a joint containing a balloon. The sample was set on a hotplate to stir at room temperature.

[0049] (3) - Aluminum Zirconium TetrachlorohydroxGly (Ventii) and artificial sweat were mixed together before adding to the 125 mL erienmeyer flask with a stirbar. The sample was closed with a joint containing a balloon. The sample was set on a hotplate to stir at room temperature.

[0050] (4) - Catalase and artificial sweat were mixed together before adding to the 25 mL erienmeyer flask with a stirbar. The sample was closed with a joint containing a balloon. The sample was set on a hotplate to stir at room temperature.

[0051] All joints were sealed with vacuum grease and covered with parafilm.

[0052] Generation of oxygen was measured using a GasBadge Pro from industrial Scientific (www, lNDSCI.com). Measurements were taken only on samples with an inflated balloon.

[0053] Table of Results showing generation of oxygen over time

Claims

WHAT IS CLAIMED IS:

1. An antiperspirant composition, comprising: (a) a carrier materia!; (b) an antiperspirant active in an amount from about 5% to less than 25%, by weight of the composition on an anhydrous basis; (c) a plurality of particles comprising a silica complexed with hydrogen peroxide and the silica hydrogen peroxide particles release oxygen when exposed to perspiration.

2. The antiperspirant composition of claim 1 , wherein the antiperspirant active is included in an amount from about 10% to less than or equal to about 15%, by weight of the composition on an anhydrous basis.

3. The antiperspirant composition of claim 1 , wherein the antiperspirant active is included in an amount of about 20%, by weight of the composition on an anhydrous basis.

4. The antiperspirant composition of claim 1 , wherein the percent of the silica that is complexed with the hydrogen peroxide is present in the compositon at about 3% to about 50% of the composition.

5. The antiperspirant composition of claim 1 , wherein the percent of the silica that is complexed with the hydrogen peroxide is present in the compositon at about 50% of the composition.

6. The antiperspirant composition of claim 1 , wherein the percent of the silica that is complexed with the hydrogen peroxide is about 25%.

7. The antiperspirant composition of claim 1 , wherein the percent of the hydrogen peroxide that is complexed with the silica is about 5% to about 30%.

8. The antiperspirant composition of claim 1 , wherein the percent of the silica that is complexed with the hydrogen peroxide is about 20%.

9. The antiperspirant composition of claim 1 wherein the silica is hydrophobic.

10. The antiperspirant of claim 9 wherein the silica is a fumed silica, a hydrated silica, a silica si!ylate, or a silica silyiate dimethicone.

11. The antiperspirant composition of claim 1 wherein the particles are configured to release hydrogen peroxide over time in an environment having a pH of about 5.4 to about 6.4.

12. The antiperspirant composition of claim 1 wherein the particles are configured to be at least partially dissolved in an environment having a pH of at about 5.4.

13. The antiperspirant composition of claim 1 wherein the particles are configured to be at least partially dissolved in an environment having a pH of about 6.4.

14. The antiperspirant composition of claim 1 wherein the plurality of particles comprise about 0.05 to about 8 wt. % of the antiperspirant composition.

15. The antiperspirant composition of claim 1, wherein the composition is in a form selected from the group consisting of solid and soft solid.

16. A method of merchandising antiperspirant or deodorant compositions, comprising the step of communicating a comparison to perspective buyers between a first antiperspirant/deodorant composition comprising a silica hydrogen peroxide complex and a second antiperspirant/deodorant composition that comprises hydrogen peroxide and no silica and a third antiperspirant/deodorant composition that comprises no hydrogen peroxide or silica.

17. The method of claim 16, wherein the comparison comprises a performance comparison of oxygen release over time.

18. A process for making an antiperspirant or deodorant composition comprising a silica hydrogen peroxide complex by:

a) adding an aqueous solution of hydrogen peroxide to silica; b) mixing the ingredients until no uncomplexed silica is present in the solution and the silica and hydrogen peroxide complex forms a plurality of particles : and c) adding the plurality of particles to an antiperspirant or deodorant composition.

19. The antiperspirant composition of claim 18 wherein the particles are configured to release hydrogen peroxide over time having a pH of about 5.4 to about 6.4.

20. The antiperspirant composition of claim 18, wherein the percent of the silica that is complexed with the hydrogen peroxide is present in the compositon at about 3% to about 50% of the composition.