WO2015109017A3 - Deuterated no-releasing nonoate(oxygen-bound)chromene conjugates - Google Patents

Deuterated no-releasing nonoate(oxygen-bound)chromene conjugates Download PDF

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Publication number
WO2015109017A3
WO2015109017A3 PCT/US2015/011460 US2015011460W WO2015109017A3 WO 2015109017 A3 WO2015109017 A3 WO 2015109017A3 US 2015011460 W US2015011460 W US 2015011460W WO 2015109017 A3 WO2015109017 A3 WO 2015109017A3
Authority
WO
WIPO (PCT)
Prior art keywords
deuterated
bound
oxygen
formula
nonoate
Prior art date
Application number
PCT/US2015/011460
Other languages
French (fr)
Other versions
WO2015109017A2 (en
Inventor
John J. Talley
Eduardo J. Martinez
Kevin D. Jerome
Original Assignee
Euclises Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euclises Pharmaceuticals, Inc. filed Critical Euclises Pharmaceuticals, Inc.
Publication of WO2015109017A2 publication Critical patent/WO2015109017A2/en
Publication of WO2015109017A3 publication Critical patent/WO2015109017A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides deuterated NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).
PCT/US2015/011460 2014-01-14 2015-01-14 Deuterated no-releasing nonoate(oxygen-bound)chromene conjugates WO2015109017A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461927352P 2014-01-14 2014-01-14
US61/927,352 2014-01-14

Publications (2)

Publication Number Publication Date
WO2015109017A2 WO2015109017A2 (en) 2015-07-23
WO2015109017A3 true WO2015109017A3 (en) 2015-11-19

Family

ID=53543410

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2015/011460 WO2015109017A2 (en) 2014-01-14 2015-01-14 Deuterated no-releasing nonoate(oxygen-bound)chromene conjugates
PCT/US2015/011457 WO2015109014A1 (en) 2014-01-14 2015-01-14 No-releasing nonoate(oxygen-bound)chromene conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2015/011457 WO2015109014A1 (en) 2014-01-14 2015-01-14 No-releasing nonoate(oxygen-bound)chromene conjugates

Country Status (1)

Country Link
WO (2) WO2015109017A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104860914B (en) * 2014-02-26 2018-09-14 中国科学院广州生物医药与健康研究院 Sulfur pentafluoride replaces benzopyrans compounds and its application
EP3215140A4 (en) * 2014-11-06 2018-05-02 The Arizona Board of Regents On Behalf of the University of Arizona Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer
CN105585547A (en) * 2016-03-09 2016-05-18 中国科学院广州生物医药与健康研究院 4-sulfur pentafluoride phenol compound, preparing method and preparing method for sulfur pentafluoride substituted benzopyran compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109211B2 (en) * 1997-04-21 2006-09-19 Pharmacia Corporation (Of Pfizer, Inc.) Substituted benzopyran derivatives for the treatment of inflammation
US20130225655A1 (en) * 2010-05-04 2013-08-29 Patrick Y. Lu Combinations of TGFBeta and COX-2 Inhibitors and Methods for Their Therapeutic Application
US20130289003A1 (en) * 2010-10-29 2013-10-31 Amjad Ali Diazeniumdiolate heterocyclic derivatives
WO2013189121A1 (en) * 2012-06-18 2013-12-27 中国科学院广州生物医药与健康研究院 Deuterated benzopyran compound and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109211B2 (en) * 1997-04-21 2006-09-19 Pharmacia Corporation (Of Pfizer, Inc.) Substituted benzopyran derivatives for the treatment of inflammation
US20130225655A1 (en) * 2010-05-04 2013-08-29 Patrick Y. Lu Combinations of TGFBeta and COX-2 Inhibitors and Methods for Their Therapeutic Application
US20130289003A1 (en) * 2010-10-29 2013-10-31 Amjad Ali Diazeniumdiolate heterocyclic derivatives
WO2013189121A1 (en) * 2012-06-18 2013-12-27 中国科学院广州生物医药与健康研究院 Deuterated benzopyran compound and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARTELLI ET AL.: "NO -Releasing Hybrids of Cardiovascular Drugs'.", CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 609 - 625, XP009087275, DOI: doi:10.2174/092986706776055634 *

Also Published As

Publication number Publication date
WO2015109017A2 (en) 2015-07-23
WO2015109014A1 (en) 2015-07-23

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