WO2015107553A3 - A process for the preparation of crizotinib or an acid addition salt thereof - Google Patents

A process for the preparation of crizotinib or an acid addition salt thereof Download PDF

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Publication number
WO2015107553A3
WO2015107553A3 PCT/IN2015/000029 IN2015000029W WO2015107553A3 WO 2015107553 A3 WO2015107553 A3 WO 2015107553A3 IN 2015000029 W IN2015000029 W IN 2015000029W WO 2015107553 A3 WO2015107553 A3 WO 2015107553A3
Authority
WO
WIPO (PCT)
Prior art keywords
crizotinib
preparation
acid addition
addition salt
dihydrochloride
Prior art date
Application number
PCT/IN2015/000029
Other languages
French (fr)
Other versions
WO2015107553A2 (en
Inventor
Satyanarayana Chava
Seeta Rama Anjaneyulu GORANTLA
Venkata Sunil Kumar Indukuri
Venkata Rama Krishna Murthy MOTURU
Veera Venkateswara Rao KARUTURI
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of WO2015107553A2 publication Critical patent/WO2015107553A2/en
Publication of WO2015107553A3 publication Critical patent/WO2015107553A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The present invention is relates to a process for the preparation of crizotinib or an acid addition salts thereof. More specifically the invention pertains to crizotinib free base in amorphous form and crizotinib dihydrochloride in crystalline and amorphous Forms and pharmaceutical compositions containing the same.
PCT/IN2015/000029 2014-01-15 2015-01-16 A process for the preparation of crizotinib or an acid addition salt thereof WO2015107553A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN166CH2014 2014-01-15
IN166/CHE/2014 2014-01-15

Publications (2)

Publication Number Publication Date
WO2015107553A2 WO2015107553A2 (en) 2015-07-23
WO2015107553A3 true WO2015107553A3 (en) 2015-11-26

Family

ID=53543583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000029 WO2015107553A2 (en) 2014-01-15 2015-01-16 A process for the preparation of crizotinib or an acid addition salt thereof

Country Status (1)

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WO (1) WO2015107553A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108341802B (en) * 2018-04-16 2020-09-08 浙江科聚生物医药有限公司 Synthesis method of antineoplastic drug crizotinib

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2620140A1 (en) * 2012-01-26 2013-07-31 ratiopharm GmbH Crizotinib containing compositions
WO2013181251A1 (en) * 2012-05-29 2013-12-05 Ratiopharm Gmbh Crizotinib hydrochloride salt in crystalline

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2620140A1 (en) * 2012-01-26 2013-07-31 ratiopharm GmbH Crizotinib containing compositions
WO2013181251A1 (en) * 2012-05-29 2013-12-05 Ratiopharm Gmbh Crizotinib hydrochloride salt in crystalline

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTHIAS BELLER ET AL., ORGANOMETALLICS AS CATALYSTS IN THE FINE CHEMICAL INDUSTRY, 27 June 2011 (2011-06-27) *

Also Published As

Publication number Publication date
WO2015107553A2 (en) 2015-07-23

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