WO2015095437A8 - Methods and intermediates for the preparation of macrolactams - Google Patents

Methods and intermediates for the preparation of macrolactams Download PDF

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Publication number
WO2015095437A8
WO2015095437A8 PCT/US2014/071014 US2014071014W WO2015095437A8 WO 2015095437 A8 WO2015095437 A8 WO 2015095437A8 US 2014071014 W US2014071014 W US 2014071014W WO 2015095437 A8 WO2015095437 A8 WO 2015095437A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
macrolactams
methods
hcv
intermediates
Prior art date
Application number
PCT/US2014/071014
Other languages
French (fr)
Other versions
WO2015095437A1 (en
Inventor
Jongrock Kong
Mark Mclaughlin
Michael Williams
Zhiguo Jake Song
Yonggang Chen
Yan Jin
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of WO2015095437A1 publication Critical patent/WO2015095437A1/en
Publication of WO2015095437A8 publication Critical patent/WO2015095437A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
PCT/US2014/071014 2013-12-20 2014-12-18 Methods and intermediates for the preparation of macrolactams WO2015095437A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361919137P 2013-12-20 2013-12-20
US61/919,137 2013-12-20

Publications (2)

Publication Number Publication Date
WO2015095437A1 WO2015095437A1 (en) 2015-06-25
WO2015095437A8 true WO2015095437A8 (en) 2016-02-04

Family

ID=53403665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/071014 WO2015095437A1 (en) 2013-12-20 2014-12-18 Methods and intermediates for the preparation of macrolactams

Country Status (1)

Country Link
WO (1) WO2015095437A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201602693QA (en) * 2013-10-18 2016-05-30 Merck Sharp & Dohme Methods and intermediates for preparing macrolactams

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279304B2 (en) * 2000-12-18 2007-10-09 President And Fellows Of Harvard College Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
AU2011344075A1 (en) * 2010-12-14 2013-05-09 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
WO2012142457A2 (en) * 2011-04-15 2012-10-18 The Broad Institute, Inc. Macrolactam compounds and methods for the treatment of malaria
AU2012299223A1 (en) * 2011-08-19 2014-02-27 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams

Also Published As

Publication number Publication date
WO2015095437A1 (en) 2015-06-25

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