WO2015091842A3 - Method for removing protein-bound uremic toxins by adsorption to auxiliary substances that can be subjected to dialysis - Google Patents

Method for removing protein-bound uremic toxins by adsorption to auxiliary substances that can be subjected to dialysis Download PDF

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Publication number
WO2015091842A3
WO2015091842A3 PCT/EP2014/078538 EP2014078538W WO2015091842A3 WO 2015091842 A3 WO2015091842 A3 WO 2015091842A3 EP 2014078538 W EP2014078538 W EP 2014078538W WO 2015091842 A3 WO2015091842 A3 WO 2015091842A3
Authority
WO
WIPO (PCT)
Prior art keywords
dialysis
adsorption
subjected
auxiliary substances
removing protein
Prior art date
Application number
PCT/EP2014/078538
Other languages
German (de)
French (fr)
Other versions
WO2015091842A2 (en
Inventor
Rainer Fislage
Original Assignee
Fresenius Medical Care Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland Gmbh filed Critical Fresenius Medical Care Deutschland Gmbh
Publication of WO2015091842A2 publication Critical patent/WO2015091842A2/en
Publication of WO2015091842A3 publication Critical patent/WO2015091842A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3465—Substitution fluids using dialysate as substitution fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention relates to a method for removing protein-bound uremic toxins by adsorption to auxiliary substances that can be subjected to dialysis, to a device for carrying out said method, and to the use of auxiliary substances in said method.
PCT/EP2014/078538 2013-12-20 2014-12-18 Method for removing protein-bound uremic toxins by adsorption to auxiliary substances that can be subjected to dialysis WO2015091842A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013021957.4 2013-12-20
DE102013021957.4A DE102013021957A1 (en) 2013-12-20 2013-12-20 Method for removing protein-bound uremic toxins by adsorption to dialyzable excipients

Publications (2)

Publication Number Publication Date
WO2015091842A2 WO2015091842A2 (en) 2015-06-25
WO2015091842A3 true WO2015091842A3 (en) 2015-08-13

Family

ID=52134196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/078538 WO2015091842A2 (en) 2013-12-20 2014-12-18 Method for removing protein-bound uremic toxins by adsorption to auxiliary substances that can be subjected to dialysis

Country Status (2)

Country Link
DE (1) DE102013021957A1 (en)
WO (1) WO2015091842A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017113853A1 (en) * 2017-06-22 2018-12-27 B. Braun Avitum Ag Hemocompatible adsorbent for dialysis of protein-bound uremic toxins
WO2024073056A1 (en) * 2022-09-29 2024-04-04 Kureha America, Inc. Cucurbituril compositions, products, and methods of use

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889634A (en) * 1988-10-04 1989-12-26 Gynex, Inc. Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
JPH0871146A (en) * 1994-09-09 1996-03-19 Baxter Kk Peritoneum dialyzing liquid containing cyclodextrin or derivative thereof
WO2003094998A1 (en) * 2002-05-14 2003-11-20 Kreymann Bernhard Dr Device for removing protein-bound substances
WO2007013123A1 (en) * 2005-07-28 2007-02-01 Humanitas Mirasole S.P.A. Cyclodextrins for blood detoxification
WO2011116909A1 (en) * 2010-03-22 2011-09-29 Fresenius Medical Care Deutschland Gmbh Pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrin
WO2011116908A1 (en) * 2010-03-22 2011-09-29 Fresenius Medical Care Deutschland Gmbh Pharmaceutical composition containing cyclodextrin copolymer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1466702A (en) 1973-02-09 1977-03-09 Sandoz Ltd Polymer encapsulated-activated carbon
US4140652A (en) 1977-01-12 1979-02-20 Korshak Vasily V Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons
FR2680975B1 (en) 1991-09-10 1998-12-31 Hospal Ind ARTIFICIAL KIDNEY WITH MEANS FOR DETERMINING A SUBSTANCE IN BLOOD.
JP2001523139A (en) 1997-05-07 2001-11-20 アンフォメ ソシエテ アノニム Control method of blood purification device
WO2000009182A1 (en) 1998-08-11 2000-02-24 Alpamed S.A. Fluid driving device
ES2821448T3 (en) 2008-06-23 2021-04-26 Temasek Polytechnic Sorbent for a dialysis device
US8206591B2 (en) 2008-10-16 2012-06-26 Fresenius Medical Care Holdings, Inc. Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889634A (en) * 1988-10-04 1989-12-26 Gynex, Inc. Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
JPH0871146A (en) * 1994-09-09 1996-03-19 Baxter Kk Peritoneum dialyzing liquid containing cyclodextrin or derivative thereof
WO2003094998A1 (en) * 2002-05-14 2003-11-20 Kreymann Bernhard Dr Device for removing protein-bound substances
WO2007013123A1 (en) * 2005-07-28 2007-02-01 Humanitas Mirasole S.P.A. Cyclodextrins for blood detoxification
WO2011116909A1 (en) * 2010-03-22 2011-09-29 Fresenius Medical Care Deutschland Gmbh Pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrin
WO2011116908A1 (en) * 2010-03-22 2011-09-29 Fresenius Medical Care Deutschland Gmbh Pharmaceutical composition containing cyclodextrin copolymer

Also Published As

Publication number Publication date
WO2015091842A2 (en) 2015-06-25
DE102013021957A1 (en) 2015-06-25

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