WO2015091163A1 - Disinfectant composition with excellent foam profile - Google Patents
Disinfectant composition with excellent foam profile Download PDFInfo
- Publication number
- WO2015091163A1 WO2015091163A1 PCT/EP2014/077252 EP2014077252W WO2015091163A1 WO 2015091163 A1 WO2015091163 A1 WO 2015091163A1 EP 2014077252 W EP2014077252 W EP 2014077252W WO 2015091163 A1 WO2015091163 A1 WO 2015091163A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- composition
- disinfectant composition
- agents
- disinfectant
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 80
- 239000000645 desinfectant Substances 0.000 title claims abstract description 54
- 239000006260 foam Substances 0.000 title abstract description 11
- 239000012459 cleaning agent Substances 0.000 claims abstract description 27
- 150000001412 amines Chemical class 0.000 claims abstract description 20
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 238000004140 cleaning Methods 0.000 claims description 21
- -1 alkyl dimethylamine oxide Chemical compound 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 13
- 150000003856 quaternary ammonium compounds Chemical group 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000011012 sanitization Methods 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 150000001450 anions Chemical class 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- 239000003139 biocide Substances 0.000 claims description 5
- 239000002304 perfume Substances 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- 239000000975 dye Substances 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 239000011814 protection agent Substances 0.000 claims description 4
- 239000005871 repellent Substances 0.000 claims description 4
- 230000002940 repellent Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000005299 abrasion Methods 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims description 2
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 claims description 2
- 230000006750 UV protection Effects 0.000 claims description 2
- 238000004061 bleaching Methods 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 230000000249 desinfective effect Effects 0.000 abstract description 3
- 239000011888 foil Substances 0.000 description 14
- TWRQCVNFACGORI-UHFFFAOYSA-N hexane;dihydrochloride Chemical compound Cl.Cl.CCCCCC TWRQCVNFACGORI-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 150000004820 halides Chemical class 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- OGBDBLQBNVXCJX-UHFFFAOYSA-N hexane tetrahydrochloride Chemical compound Cl.Cl.Cl.Cl.CCCCCC OGBDBLQBNVXCJX-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
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- 239000002253 acid Substances 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 239000003125 aqueous solvent Substances 0.000 description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229940117927 ethylene oxide Drugs 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 150000003512 tertiary amines Chemical class 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 2
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 2
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 229960001716 benzalkonium Drugs 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- UMGXUWVIJIQANV-UHFFFAOYSA-M didecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC UMGXUWVIJIQANV-UHFFFAOYSA-M 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
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- 239000011521 glass Substances 0.000 description 2
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
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- FFQQCJGNKKIRMD-UHFFFAOYSA-N methyl n-(3-hydroxyphenyl)carbamate Chemical compound COC(=O)NC1=CC=CC(O)=C1 FFQQCJGNKKIRMD-UHFFFAOYSA-N 0.000 description 2
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- DLZPLSBQNQBHJH-UHFFFAOYSA-N (2-ethyl-1-iodopentyl) carbamate Chemical compound CCCC(CC)C(I)OC(N)=O DLZPLSBQNQBHJH-UHFFFAOYSA-N 0.000 description 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 1
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- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
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- YHGREDQDBYVEOS-UHFFFAOYSA-N [acetyloxy-[2-(diacetyloxyamino)ethyl]amino] acetate Chemical class CC(=O)ON(OC(C)=O)CCN(OC(C)=O)OC(C)=O YHGREDQDBYVEOS-UHFFFAOYSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
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- 125000005024 alkenyl aryl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
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- 229940100198 alkylating agent Drugs 0.000 description 1
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- 238000005804 alkylation reaction Methods 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
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- UUSQFLGKGQEVCM-UHFFFAOYSA-M benzoxonium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](CCO)(CCO)CC1=CC=CC=C1 UUSQFLGKGQEVCM-UHFFFAOYSA-M 0.000 description 1
- 229960001574 benzoxonium chloride Drugs 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
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- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
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- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- NEHMKBQYUWJMIP-NJFSPNSNSA-N chloro(114C)methane Chemical compound [14CH3]Cl NEHMKBQYUWJMIP-NJFSPNSNSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N cinnamic acid Chemical class OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001896 cresols Chemical class 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000392 cycloalkenyl group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- BYNQFCJOHGOKSS-UHFFFAOYSA-N diclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1 BYNQFCJOHGOKSS-UHFFFAOYSA-N 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical class OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
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- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- SNGREZUHAYWORS-UHFFFAOYSA-N perfluorooctanoic acid Chemical class OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F SNGREZUHAYWORS-UHFFFAOYSA-N 0.000 description 1
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical class C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
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- 230000037452 priming Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- PXGPLTODNUVGFL-JZFBHDEDSA-N prostaglandin F2beta Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H](O)[C@@H]1C\C=C/CCCC(O)=O PXGPLTODNUVGFL-JZFBHDEDSA-N 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 238000005956 quaternization reaction Methods 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003899 tartaric acid esters Chemical class 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- JREYOWJEWZVAOR-UHFFFAOYSA-N triazanium;[3-methylbut-3-enoxy(oxido)phosphoryl] phosphate Chemical compound [NH4+].[NH4+].[NH4+].CC(=C)CCOP([O-])(=O)OP([O-])([O-])=O JREYOWJEWZVAOR-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/835—Mixtures of non-ionic with cationic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/75—Amino oxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0094—High foaming compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
- C11D2111/14—Hard surfaces
Definitions
- the present invention relates to a disinfectant composition with excellent foam profile comprising amine oxide and a cationic surfactant.
- This composition can be used for disinfecting hard surfaces and is also suited for use in cleaning agents.
- the invention also relates to the use of the disinfectant composition as such or in cleaning agents.
- disinfectant- containing cleaning agents are widely used.
- active components such as disinfectants and/or surfactants.
- these compositions have to perform equally well or better in cleaning and disinfecting, particularly hard surfaces, than known compositions.
- compositions which also show an excellent foam profile to satisfy consumer expectations. This is especially the case, if in the consumer's opinion more foam means superior cleaning and disinfectant capabilities.
- many of the currently used disinfectants still rely on comparably high amounts of actives to achieve satisfactory results in disinfection and cleaning.
- Alternative active compounds that would allow the use of lower amounts of active ingredients are however generally too expensive for use in cleaning agents.
- the excellent foam profile also leads to superior cleaning properties compared to a cleaning composition with lesser foaming.
- the inventive composition requires a lower dose of active components to achieve excellent cleaning results and hence saves resources and is more environmentally friendly.
- the present invention is therefore directed to a disinfectant composition with a pH value of 5-6 comprising amine oxide in an amount of 0.3-1.0 wt.% and a cationic surfactant. It has been demonstrated that the disinfectant composition can advantageously be used in a cleaning agent, in particular a cleaning agent for hard surfaces, which contains other typical ingredients of cleaning agents. In another aspect, the present invention thus also relates to a cleaning agent comprising the disinfectant composition of the invention.
- the present invention relates to the use of the disinfectant composition or the cleaning agent of the invention for cleaning and/or sanitizing an object, preferably a hard surface.
- the use can comprise applying the composition or cleaning agent to the object and, optionally after a contact time of 1 to 15 minutes, rubbing it with a brush, sponge or cloth against the surface.
- the present invention also encompasses a method for cleaning and/or sanitizing an object, preferably a hard surface, comprising contacting said object with a disinfectant composition or cleaning agent of the invention.
- the method can also further comprise the step of rubbing the composition or cleaning agent with a brush, sponge or cloth against the surface, optionally after a contact time of 1 to 15 minutes.
- fatty acids or fatty alcohols and their derivatives represent branched or linear carboxylic acids and alcohols and their derivatives, respectively, preferably those with 6 to 22 carbon atoms.
- the former are particularly preferred due to environmental reasons, but the present invention is not limited to them.
- biocidal agent or antimicrobial compound or disinfectant in the context of this application refers to compounds, which possess an antimicrobial action and reduce the number of microorganisms on objects, in particular surfaces, treated therewith.
- Amine oxides suitable for the present invention have the general formula R R 2 R 3 NO, wherein each R , R 2 und R 3 independently from each other can be a O to C30 chain of carbon atoms, which is optionally substituted, preferably linear or branched saturated C1-30 alkyl, more preferably unsubstituted linear C1-20 alkyl.
- R and R 2 are C1-4 alkyl, preferably unsubstituted alkyl, more preferably methyl or ethyl, most preferably methyl
- R 3 is C8-20 alkyl, preferably unsubstituted C8-20 alkyl, more preferably unsubstituted C10-18 alkyl, most preferably unsubstituted C12-16 alkyl.
- the amine oxide is a C12-14 alkyl dimethylamine oxide.
- the disinfectant composition comprises at least one amine oxide, but may contain more than one amine oxide.
- amine oxide is generally present in amounts of 0.3-1.0 wt.% with respect to the complete composition, a preferred amount is in the range of 0.4-0.5 wt.% amine oxide.
- the disinfectant composition further comprises at least one cationic surfactant.
- the cationic surfactant may be present in the composition in a quantity of 0.1 wt.% to 2.5 wt.%, preferably 0.2 wt.% to 1.0 wt.%, more preferably 0.3 wt.% to 0.6 wt.% and most preferably 0.4 to 0.55 wt.%. It is particularly preferred from a toxicological and ecological viewpoint for the quantity of cationic surfactant compound to be less than 2.5 wt.%.
- the cationic surfactant is a quaternary ammonium compound.
- Suitable quaternary ammonium compounds have the general formula (R )(R 2 )(R 3 )(R 4 )N + X-, wherein each of R , R 2 , R 3 and R 4 is independently linear or branched C1-C22 alkyl, C2-C22 alkenyl, C2-C22 alkynyl or C7-C28 alk(en)ylaryl that can optionally be substituted or any two or three of R , R 2 , R 3 and R 4 combine to form a 5-6-membered, optionally aromatic, heterocyclic ring with the nitrogen atom to which they are attached; and X " is an anion.
- the alkyl moieties can comprise 1 to 22 carbon atoms, but preferably are either lower alkyl, comprising 1 to 4 carbon atoms, or Cs-Os alkyl. They are preferably linear. When substituted they can be substituted with any one or more substituents selected from the group consisting of -OR, halo, nitro, -NRR', cyano, -C(0)R, -C(0)OR, -(CO)NRR', -NR'C(0)R, -OC(0)R, C5-C20 aryl, C3-C20 cycloalk(en)yl, 3- to 8-membered heterocycloalk(en)yl, and 5- to 20-membered heteroaryl, wherein R and R' are independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C5-C14 aryl, C3-C8 cycloalk(en)yl, 5- to
- alkenyl and alkynyl moieties comprise one or more carbon-carbon double bonds or triple bonds, respectively, and are otherwise defined as alkyl above. Specifically, they are preferably linear and if substituted they are substituted with a substituent selected from the above list of substituents.
- Cycloalkyl refers to a non-aromatic carbocyclic moiety, such as cyclopentanyl, cyclohexanyl and the like.
- Cycloalkenyl refers to non-aromatic carbocyclic compounds that comprise at least one C-C double bond.
- heterocycloalk(en)yl relates to cycloalk(en)yl groups wherein 1 or more ring carbon atoms are replaced by heteroatoms, preferably selected from N , O and S.
- Aryl relates to an aromatic ring that is preferably monocyclic or consists of condensed aromatic rings.
- Preferred aryl substituents are C6-C12 aryl moieties, such as phenyl, naphthyl, anthracenyl and phenanthrenyl.
- Heteroaryl refers to aromatic moieties that correspond to the respective aryl moiety wherein one or more ring carbon atoms have been replaced by heteroatoms, such as N, O and S.
- Alkylaryl and alkenylaryl relate to alkyl or alkenyl groups that are substituted with an aryl group, such as benzyl.
- R and R 2 are unsubstituted C1-C4 alkyl, preferably methyl, and/or R 3 and R 4 are defined as follows:
- R 3 is (Ci-C 4 )alkyl(C6-Ci4)aryl, preferably benzyl, and R 4 is unsubstituted Cs-Cis alkyl; or (ii) R 3 is unsubstituted C1-C4 alkyl, preferably methyl, and R 4 is (meth)acryloxy(Ci-C4)alkyl, preferably acryloxyethyl; or (iii) R 3 and R 4 are independently unsubstituted Cs-C-is alkyl.
- R -R 14 In case any two or three of R -R 14 combine to form a cyclic moiety with the nitrogen atom to which they are attached , this means that for example two or three of R -R 14 together are an alkyl or alkenyl group as defined above that forms a ring with the nitrogen atom.
- the ring may be an aromatic, monocylic or bicyclic ring .
- X " is selected from the group consisting of halide, sulfate, hydroxide, phosphate, preferably halide, more preferably chloride.
- Halide includes fluoride, chloride, bromide and iodide.
- the anion can be selected such that the QAC is render water- soluble.
- the anion is selected from halide, methosulfate, methophosphate or phosphate and mixtures of these or similar anions.
- the anion may be a carboxylic acid derived organic anion such as acetate, propionate, citrate, lactate, tartrate and the like
- QACs can be produced by reacting tertiary amines with alkylating agents, such as e.g. methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide.
- alkylating agents such as e.g. methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide.
- alkylating agents such as e.g. methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide.
- alkylating agents such as e.g. methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide.
- the alkylation of tertiary amines with a long alkyl residue and two methyl groups is achieved particularly readily, and even the quaternization of
- Suitable QACs are for example benzalkonium chloride (N-alkyl-N,N-dimethylbenzylammonium chloride, CAS No. 8001-54-5), benzalkon B (m,p-dichlorobenzyldimethyl-Ci2-alkylammonium chloride, CAS No. 58390-78-6), benzoxonium chloride (benzyldodecylbis(2- hydroxyethyl)ammonium chloride), cetrimonium bromide (N-hexadecyl-N,N,N-trimethylammonium bromide, CAS No.
- benzethonium chloride N,N-dimethyl-N-[2-[2-[p-(1 , 1 ,3,3- tetramethylbutyl)phenoxy]ethoxy]ethyl]benzylammonium chloride, CAS No. 121 -54-0
- dialkyldimethylammonium chlorides such as di-n-decyldimethyl-ammonium chloride (CAS No. 7173-51-5-5), didecyldimethylammonium bromide (CAS No. 2390-68-3), dioctyldimethylammonium chloride, 1 -cetylpyridinium chloride (CAS No.
- QACs are dialkyldimethylammonium chlorides, in particular di-n-decyldimethylammonium chloride, N-octadecyl-N,N,N-trimethylammonium chloride, N-hexadecyl-N,N,N-trimethylammonium chloride and the benzalkonium chlorides with Cs-C-is alkyl residues, in particular Ci2-Ci4 alkylbenzyldimethylammonium chloride.
- Another preferred compound is methyl-N-(2-hydroxyethyl)-N,N-di(caproyloxyethyl)ammonium methosulfate.
- dialkyldimethylammonium halides the benzalkonium halides and/or substituted benzalkonium halides are commercially available, for example as Barquat ® from Lonza, Marquat ® from Mason, Variquat ® from Evonik Industries and Hyamine ® from Lonza.
- the cationic surfactant is a QAC of formula (R )(R 2 )(R 3 )(R 4 )N + X " , as defined above, for example a QAC of the given formula wherein R and R 2 are unsubstituted Ci- C4 alkyl, preferably methyl, and (i) R 3 is (Ci-C4)alkyl(C6-Ci4)aryl, preferably benzyl, and R 4 is unsubstituted Cs-C-is alkyl; or (ii) R 3 is unsubstituted C1-C4 alkyl, preferably methyl, and R 4 is (meth)acryloxy(Ci-C4)alkyl, preferably acryloxyethyl; or (iii) R 3 and R 4 are independently unsubstituted Cs-C-is alkyl; and the amine oxide is of the formula R R 2 R 3 NO, as defined above, preferably a C12-14 alkyl
- composition or cleaning agent may in certain embodiments comprise additional non-ionic surfactants, i.e. non-ionic surfactants other than amine oxide, such as a non-ionic surfactant selected from the group consisting of poly alkoxylates, alkoxylated fatty alcohols, alkoxylated fatty acids, alkoxylated alkylphenols and block copolymers of ethylene oxide and propylene oxide.
- additional non-ionic surfactants i.e. non-ionic surfactants other than amine oxide
- non-ionic surfactant selected from the group consisting of poly alkoxylates, alkoxylated fatty alcohols, alkoxylated fatty acids, alkoxylated alkylphenols and block copolymers of ethylene oxide and propylene oxide.
- the composition does not contain any non- ionic surfactant other than the amine oxide.
- the disinfectant composition of the invention can be comprised in a cleaning agent, as described above, and said cleaning agent or the disinfectant composition itself can additionally comprise one or more components that are commonly used in cleaning agents, for example those selected from the group consisting of additional disinfectants, cellulosic thickeners, viscosity regulators, dyes, perfumes, preservatives, water/stain repellents, stain release agents, refreshing agents, biocidal agents, anti-microbial agents, disinfecting agents, malodor control agents, abrasion resistance and protection agents, solvents such as water or non-aqueous solvents, insect/pet repellents, wetting agents, UV protection agents, enzymes, bleaching systems, antistats and mixtures thereof.
- additional disinfectants for example those selected from the group consisting of additional disinfectants, cellulosic thickeners, viscosity regulators, dyes, perfumes, preservatives, water/stain repellents, stain release agents, refreshing agents, biocidal agents, anti-microbial agents, disinfecting agents, mal
- Additional biocidal agents, anti-microbial agents and/or disinfecting agents that can be used in the disinfectant compositions described herein include, without being limited thereto, amines, quaternary ammonium compounds, aldehydes, antimicrobial acids and salts thereof, carboxylic acid esters, acid amides, phenols, phenol derivatives, diphenyls, diphenylalkanes, urea derivatives, oxygen acetals, oxygen formals, nitrogen acetals, nitrogen formals, benzamidines, isothiazolines, phthalimide derivatives, pyridine derivatives, guanidines, quinolines, iodine, iodophores, halogen compounds and mixtures thereof.
- biocidal compounds that may be used include, without limitation, 1 ,2- dibromo-2,4-dicyanobutane, iodo-2-propylbutyl carbamate, undecylenic acid, salicylic acid, dihydroacetic acid, o-phenylphenol, N-methylmorpholinoacetonitrile (MMA), 2-benzyl-4- chlorophenol, 2,2'-methylenebis(6-bromo-4-chlorophenol), 4,4'-dichloro-2'-hydroxydiphenyl ether (diclosan), 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), chlorhexidine, N-(4-chlorophenyl)-N- (3,4-dichlorophenyl)urea, N,N'-(1 ,10-decanediyldi-1-pyridinyl-4-ylidene)-
- MMA N-methylmorpholinoacetonitrile
- the cationic surfactant is a quaternary ammonium compound and this quaternary ammonium compound at the same time also represents the disinfecting agent, i.e. the active disinfectant.
- the cellulosic thickener is selected from the group consisting of cellulose, carboxymethyl cellulose or the sodium salt thereof, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, cellulose acetate and mixtures thereof.
- Preferred thickeners include hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, and hydroxyethyl methyl cellulose, in particular hydroxyethyl cellulose.
- Suitable cellulosic thickeners are commercially available from a variety of sources, for example as Cellosize QP 100 MH from Dow Chemicals, as Benecel MP 333 C, Culminal MC 2000 S and Culminal MHPC 3000 from Hercules, and MHEC 5000 PR and MHPC 600 R from Henkel.
- the inventive disinfectant composition may be a liquid disinfectant composition.
- the disinfectant composition of the invention can be an aqueous composition and can, in various embodiments, comprise at least 50 wt.% water, preferably at least 70 wt.% water or more.
- the composition additionally contains non-aqueous solvents for example selected from the group of monohydric or polyhydric alcohols, alkanolamines or glycol ethers, provided that they are miscible with water in the concentration range given.
- the solvents are preferably selected from ethanol, n- or i-propanol, butanols, glycol, propanediol or butanediol, glycerol, diglycol, propyl or butyl diglycol, hexylene glycol, ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol mono-n-butyl ether, diethylene glycol methyl ether, diethylene glycol ethyl ether, propylene glycol methyl, ethyl or propyl ether, dipropylene glycol monomethyl or ethyl ether, di-isopropylene glycol monomethyl or ethyl
- the disinfectant composition comprises 0.5 to 5, preferably 0.5 to 2.5 wt.% ethanol and/or isopropanol. Ethanol and isopropanol also possess an antimicrobial activity and thus extend the spectrum of action of the disinfectant composition.
- the disinfectant composition comprises a perfume composition in a quantity of usually up to 2 wt.%, preferably 0.01 to 1 wt.%, particularly 0.02 to 0.75 wt.% and particularly preferably 0.04 to 0.4 wt.%.
- the perfume composition can contain individual fragrance compounds, for example the synthetic products of the type of the esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Preferably, however, mixtures of various fragrances are used which together produce an attractive scent.
- the perfume composition can also contain natural fragrance compounds as may be obtained from plant sources.
- pH adjusters In order to bring the pH of the composition into the desired range, the use of pH adjusters may be indicated. All known acids or lyes may be used here, provided that their use is not prohibited for reasons of application technology or on ecological grounds, or for reasons of consumer protection.
- compositions can be colored using suitable dyes.
- Preferred dyes the selection of which offers no problem to the person skilled in the art, possess high storage stability and are not sensitive to the other ingredients of the composition and to light.
- the disinfectant composition may be part of a cleaning agent, the cleaning agent also being encompassed by the present invention.
- the cleaning agent also being encompassed by the present invention.
- the invention also relates to the use of the disinfectant composition or cleaning agent according to the invention for cleaning and/or sanitizing an object, preferably a hard surface.
- the cleaning and/or sanitizing includes reducing the number of microorganisms on the object or hard surface treated therewith.
- the composition or agent according to the invention may be used to reduce the number of microorganisms in a washing or rinsing solution.
- Also encompassed by the present invention is a method for cleaning and/or sanitizing an object, preferably a hard surface, the method comprising contacting said object with a disinfectant composition or a cleaning agent according to the invention.
- the contacting may be done by pouring, spraying or otherwise wetting the object, preferably a hard surface, with the composition or agent of the invention.
- the composition may for example be applied to an object by rubbing it with a brush, sponge or cloth wetted with the composition.
- compositions according to table 1 were prepared by mixing the components in water and adjusting the final pH value with citric acid. All amounts given in table 1 are wt.% if not otherwise noted.
- the cleaning performance and foam profile of all non-ionic surfactants listed above were analyzed in a disinfectant formula.
- the composition comprising 0.3, 0.4 or 0.5 wt.% amine oxide did not only show a great improvement in cleaning performance, but also exhibited the best foam profile in hard and soft water. Moreover, it allows for a much more sustainable formula as a lower dose of chemical is necessary.
- This method involved wiping a white dirt carrier treated with test dirt with a sponge soaked in the test specimen under defined conditions.
- the main features of the test method were published in 1986 as IPP quality standards in the journal "Seifen-Ole-Fette-Wachse” (Soaps-oils-greases-waxes), 1 12th volume, number 10, pages 371 -372. Production of the test dirt:
- test dirt 600 g was produced as follows:
- Adhesive Adhesin J1626-21 (Henkel)
- Cardboard strips (554 x 39 mm), the lengths must run in the direction of the fiber: Only hansa board 400 g/m2, smooth on one side, white, without barrier layer; Stora (formerly Feldmuhle AG), Dusseldorf, Work surface e.g. PVC, 1000 x 500 x 5 mm,
- the adhesive was diluted with 30 g of demineralized water per 1000 g adhesive.
- the cut foil sheets were used with approximate dimensions of 650 x 300 to 400mm. This measurement resulted from the roll width of 1300 mm and the width for 7 x 39 mm wide strips plus seam allowance. Halve the roll width so that a 554 mm long cardboard strip fit onto a half roll width of 650 mm.
- the foil was laid on the work surface with the smooth side down (this smooth side was later be soiled).
- the smooth side was determined by turning down a lying foil strip (approx. 30 x 10 cm) so that one third of its bottom side faces upward.
- a line was made with a red felt-tip marker lengthwise across the foil beginning at the double layer and ending at the single layer.
- the foil was cleanly cut off by protruding beyond the edges of the plate with a foil cutter.
- the plates prepared in this way were stacked for storage - and always with foil-on-foil and cardboard-on-cardboard - with the whole surface weighted, so that they stayed flat.
- Test dirt Homogenize for approx. 15 min with a magnetic stirrer before applying.
- Watch glasses (80 mm 0) for weighing the respective test dirt
- the dirt carrier plate (foil facing upwards) was covered with the template, making soiling possible in the lengthwise direction of 260 mm and of the entire 280 mm width.
- a quantity of 2.0 g of test dirt was weighed on a watch glass. If a new brush was used, it was saturated in the test dirt for 24 hours, subsequently squeezed and brushed onto the foil until no more dirt dripped off. Then the soiled brush was stored in a screw-top jar until usage.
- the dirt was further worked in by guiding the brush from the upper left to the lower left and back again along the same track. It was proceeded track-by-track with overlapping until the brush stroke ended in the upper right.
- the dirt was worked in from top to bottom.
- the brush was guided in single tracks overlapping from left to right.
- the foil was separated between the individual strips using a foil cutter.
- the stripes were then hung on a frame to be air-dried. The drying time was 1 h.
- the dimensions and the water holding capacity checks after sgueezing the sponge were made on a random basis for each new sponge delivery.
- a new order from Euroform made by Purchasing comprises around 9000 sponges. The sponges were soaked in tap water shortly before the start of the test.
- the soiled cardboard strips were laid into the guide rails of the wiping device.
- the moist sgueezed sponge was laid into the sponge cart of the cart which lied on the top side.
- 6 mL of test detergent solution was applied via a syringe to the non-soiled area of the cardboard strip.
- the cart was turned around so that the sponge rested on the strip in the guide rail and weighed it down. When turning around, it was ensured that possible dripping liguid lands on the strip. Then the wiping process was started. The sponge was wiped back and forth 10 times. Then the strip was removed from the rail and rinsed thoroughly at 20 °C with flowing tap water (before rinsing, the water should run for at least 10 min). The strip was guided diagonally downwards (angle approx. 45 °) under the water jet, so that the jet rinsed the dirt from top to bottom. The strips were hung to dry on a suitable frame for 1 hour.
- the degree of whiteness was measured with the Konica-Minolta Chroma Meter CR-400. The measurement was taken against a white standard: Clean, untreated dirt carrier strips correspond to 100% RV (cleaning capacity). 7 measured values were determined from each of the 3 cleaned strips of a test specimen (corresponded to 21 measuring points per detergent) and the corresponding mean average values were calculated.
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Abstract
The present invention relates to a disinfectant composition with excellent foam profile comprising amine oxide and a cationic surfactant. This composition can be used for disinfecting hard surfaces and is also suited for use in cleaning agents. The invention also relates to the use of the disinfectant composition as such or in cleaning agents.
Description
Disinfectant composition with excellent foam profile
The present invention relates to a disinfectant composition with excellent foam profile comprising amine oxide and a cationic surfactant. This composition can be used for disinfecting hard surfaces and is also suited for use in cleaning agents. The invention also relates to the use of the disinfectant composition as such or in cleaning agents.
Especially for sanitizing hard surfaces in hospitals as well as private households disinfectant- containing cleaning agents are widely used. To meet the growing demand for sustainable and environmental friendly products, it is desirable to have disinfectant compositions comprising a lower dose of active components, such as disinfectants and/or surfactants. At the same time, however, these compositions have to perform equally well or better in cleaning and disinfecting, particularly hard surfaces, than known compositions. Moreover, it is desirable to have compositions, which also show an excellent foam profile to satisfy consumer expectations. This is especially the case, if in the consumer's opinion more foam means superior cleaning and disinfectant capabilities. However, many of the currently used disinfectants still rely on comparably high amounts of actives to achieve satisfactory results in disinfection and cleaning. Alternative active compounds that would allow the use of lower amounts of active ingredients are however generally too expensive for use in cleaning agents.
It is therefore an object of the present invention to provide a disinfectant composition with excellent foam profile, which comprises a lower dose of disinfectant/surfactant and is based on easily available and inexpensive active components.
Surprisingly, it has now been found that this object can be met by a disinfectant composition with excellent foam profile that comprises amine oxide and a cationic surfactant and has a pH value of 5-6.
Moreover, it was found that in addition to satisfying the consumer's expectations, the excellent foam profile also leads to superior cleaning properties compared to a cleaning composition with lesser foaming.
The inventive composition requires a lower dose of active components to achieve excellent cleaning results and hence saves resources and is more environmentally friendly.
In a first aspect, the present invention is therefore directed to a disinfectant composition with a pH value of 5-6 comprising amine oxide in an amount of 0.3-1.0 wt.% and a cationic surfactant.
It has been demonstrated that the disinfectant composition can advantageously be used in a cleaning agent, in particular a cleaning agent for hard surfaces, which contains other typical ingredients of cleaning agents. In another aspect, the present invention thus also relates to a cleaning agent comprising the disinfectant composition of the invention.
In still another aspect, the present invention relates to the use of the disinfectant composition or the cleaning agent of the invention for cleaning and/or sanitizing an object, preferably a hard surface. The use can comprise applying the composition or cleaning agent to the object and, optionally after a contact time of 1 to 15 minutes, rubbing it with a brush, sponge or cloth against the surface.
In a further aspect, the present invention also encompasses a method for cleaning and/or sanitizing an object, preferably a hard surface, comprising contacting said object with a disinfectant composition or cleaning agent of the invention. The method can also further comprise the step of rubbing the composition or cleaning agent with a brush, sponge or cloth against the surface, optionally after a contact time of 1 to 15 minutes.
In the context of the present invention and if not indicated otherwise, fatty acids or fatty alcohols and their derivatives represent branched or linear carboxylic acids and alcohols and their derivatives, respectively, preferably those with 6 to 22 carbon atoms. The former are particularly preferred due to environmental reasons, but the present invention is not limited to them.
The terms "disinfection", "disinfectant", "sanitation", "antimicrobial effect", "antimicrobial agent", and "biocidal agent" as used herein, have the common meaning as understood by those skilled in the art, as for example described by K. H. Wallhausser in "Praxis der Sterilisation, Desinfektion - Konservierung: Keimidentifizierung - Betriebshygiene" (5. Aufl. - Stuttgart; New York: Thieme, 1995). While disinfection in the narrower sense of medicinal practice means the killing of - theoretically all - pathogenic germs, sanitation means the elimination of essentially all germs including those that are normally not harmful to human beings. The extent of disinfection and sanitation, respectively, is thereby dependent on the antimicrobial efficacy of the used antimicrobial agent, which decreases with decreasing concentrations and increasing dilution, respectively. Generally, as used herein, biocidal agent or antimicrobial compound or disinfectant in the context of this application refers to compounds, which possess an antimicrobial action and reduce the number of microorganisms on objects, in particular surfaces, treated therewith.
Amine oxides suitable for the present invention have the general formula R R2R3NO, wherein each R , R2 und R3 independently from each other can be a O to C30 chain of carbon atoms, which is optionally substituted, preferably linear or branched saturated C1-30 alkyl, more preferably unsubstituted linear C1-20 alkyl. In various embodiments, R and R2 are C1-4 alkyl, preferably
unsubstituted
alkyl, more preferably methyl or ethyl, most preferably methyl, and R3 is C8-20 alkyl, preferably unsubstituted C8-20 alkyl, more preferably unsubstituted C10-18 alkyl, most preferably unsubstituted C12-16 alkyl. In a preferred embodiment the amine oxide is a C12-14 alkyl dimethylamine oxide.
The disinfectant composition comprises at least one amine oxide, but may contain more than one amine oxide.
„At least one", as used herein, means one or more, e.g.1 , 2, 3, 4, 5, 6, 7, 8, 9 or more.
While the amine oxide is generally present in amounts of 0.3-1.0 wt.% with respect to the complete composition, a preferred amount is in the range of 0.4-0.5 wt.% amine oxide.
The disinfectant composition further comprises at least one cationic surfactant. The cationic surfactant may be present in the composition in a quantity of 0.1 wt.% to 2.5 wt.%, preferably 0.2 wt.% to 1.0 wt.%, more preferably 0.3 wt.% to 0.6 wt.% and most preferably 0.4 to 0.55 wt.%. It is particularly preferred from a toxicological and ecological viewpoint for the quantity of cationic surfactant compound to be less than 2.5 wt.%.
In a preferred embodiment the cationic surfactant is a quaternary ammonium compound.
Suitable quaternary ammonium compounds (QACs) have the general formula (R )(R 2)(R 3)(R 4)N+X-, wherein each of R , R 2, R 3 and R 4 is independently linear or branched C1-C22 alkyl, C2-C22 alkenyl, C2-C22 alkynyl or C7-C28 alk(en)ylaryl that can optionally be substituted or any two or three of R , R 2, R 3 and R 4 combine to form a 5-6-membered, optionally aromatic, heterocyclic ring with the nitrogen atom to which they are attached; and X" is an anion.
The alkyl moieties can comprise 1 to 22 carbon atoms, but preferably are either lower alkyl, comprising 1 to 4 carbon atoms, or Cs-Os alkyl. They are preferably linear. When substituted they can be substituted with any one or more substituents selected from the group consisting of -OR, halo, nitro, -NRR', cyano, -C(0)R, -C(0)OR, -(CO)NRR', -NR'C(0)R, -OC(0)R, C5-C20 aryl, C3-C20 cycloalk(en)yl, 3- to 8-membered heterocycloalk(en)yl, and 5- to 20-membered heteroaryl, wherein R and R' are independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C5-C14 aryl, C3-C8 cycloalk(en)yl, 5- to 14- membered heteroaryl, comprising 1 to 4 heteroatoms selected from N, O, and S, and 5- to 14- membered heterocycloalk(en)yl, comprising 1 to 4 heteroatoms selected from N, O, and S.
The alkenyl and alkynyl moieties comprise one or more carbon-carbon double bonds or triple bonds, respectively, and are otherwise defined as alkyl above. Specifically, they are preferably
linear and if substituted they are substituted with a substituent selected from the above list of substituents.
Cycloalkyl refers to a non-aromatic carbocyclic moiety, such as cyclopentanyl, cyclohexanyl and the like. Cycloalkenyl refers to non-aromatic carbocyclic compounds that comprise at least one C-C double bond. Similarly, heterocycloalk(en)yl relates to cycloalk(en)yl groups wherein 1 or more ring carbon atoms are replaced by heteroatoms, preferably selected from N , O and S.
Aryl relates to an aromatic ring that is preferably monocyclic or consists of condensed aromatic rings. Preferred aryl substituents are C6-C12 aryl moieties, such as phenyl, naphthyl, anthracenyl and phenanthrenyl.
Heteroaryl refers to aromatic moieties that correspond to the respective aryl moiety wherein one or more ring carbon atoms have been replaced by heteroatoms, such as N, O and S.
Alkylaryl and alkenylaryl relate to alkyl or alkenyl groups that are substituted with an aryl group, such as benzyl.
In preferred embodiments of the invention R and R 2 are unsubstituted C1-C4 alkyl, preferably methyl, and/or R 3 and R 4 are defined as follows:
(i) R 3 is (Ci-C4)alkyl(C6-Ci4)aryl, preferably benzyl, and R 4 is unsubstituted Cs-Cis alkyl; or (ii) R 3 is unsubstituted C1-C4 alkyl, preferably methyl, and R 4 is (meth)acryloxy(Ci-C4)alkyl, preferably acryloxyethyl; or (iii) R 3 and R 4 are independently unsubstituted Cs-C-is alkyl.
In case any two or three of R -R14 combine to form a cyclic moiety with the nitrogen atom to which they are attached , this means that for example two or three of R -R14 together are an alkyl or alkenyl group as defined above that forms a ring with the nitrogen atom. The ring may be an aromatic, monocylic or bicyclic ring .
In various embodiments of the invention, X" is selected from the group consisting of halide, sulfate, hydroxide, phosphate, preferably halide, more preferably chloride. Halide includes fluoride, chloride, bromide and iodide. The anion can be selected such that the QAC is render water- soluble. In specific embodiments, the anion is selected from halide, methosulfate, methophosphate or phosphate and mixtures of these or similar anions. Alternatively, the anion may be a carboxylic acid derived organic anion such as acetate, propionate, citrate, lactate, tartrate and the like
QACs can be produced by reacting tertiary amines with alkylating agents, such as e.g. methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide. The alkylation of tertiary amines with a long alkyl residue and two methyl groups is achieved particularly readily,
and even the quaternization of tertiary amines with two long residues and a methyl group can be carried out under mild conditions with the aid of methyl chloride. Amines having three long alkyl residues or hydroxy-substituted alkyl residues are of low reactivity and are preferably quaternized with dimethyl sulfate.
Suitable QACs are for example benzalkonium chloride (N-alkyl-N,N-dimethylbenzylammonium chloride, CAS No. 8001-54-5), benzalkon B (m,p-dichlorobenzyldimethyl-Ci2-alkylammonium chloride, CAS No. 58390-78-6), benzoxonium chloride (benzyldodecylbis(2- hydroxyethyl)ammonium chloride), cetrimonium bromide (N-hexadecyl-N,N,N-trimethylammonium bromide, CAS No. 57-09-0), benzethonium chloride (N,N-dimethyl-N-[2-[2-[p-(1 , 1 ,3,3- tetramethylbutyl)phenoxy]ethoxy]ethyl]benzylammonium chloride, CAS No. 121 -54-0), dialkyldimethylammonium chlorides such as di-n-decyldimethyl-ammonium chloride (CAS No. 7173-51-5-5), didecyldimethylammonium bromide (CAS No. 2390-68-3), dioctyldimethylammonium chloride, 1 -cetylpyridinium chloride (CAS No. 123-03-5) and thiazoline iodide (CAS No. 15764-48- 1 ) and mixtures thereof. Particularly preferred QACs are dialkyldimethylammonium chlorides, in particular di-n-decyldimethylammonium chloride, N-octadecyl-N,N,N-trimethylammonium chloride, N-hexadecyl-N,N,N-trimethylammonium chloride and the benzalkonium chlorides with Cs-C-is alkyl residues, in particular Ci2-Ci4 alkylbenzyldimethylammonium chloride. Another preferred compound is methyl-N-(2-hydroxyethyl)-N,N-di(caproyloxyethyl)ammonium methosulfate.
The dialkyldimethylammonium halides, the benzalkonium halides and/or substituted benzalkonium halides are commercially available, for example as Barquat® from Lonza, Marquat® from Mason, Variquat® from Evonik Industries and Hyamine® from Lonza.
In various embodiments, the cationic surfactant is a QAC of formula (R )(R 2)(R 3)(R 4)N+X" , as defined above, for example a QAC of the given formula wherein R and R 2 are unsubstituted Ci- C4 alkyl, preferably methyl, and (i) R 3 is (Ci-C4)alkyl(C6-Ci4)aryl, preferably benzyl, and R 4 is unsubstituted Cs-C-is alkyl; or (ii) R 3 is unsubstituted C1-C4 alkyl, preferably methyl, and R 4 is (meth)acryloxy(Ci-C4)alkyl, preferably acryloxyethyl; or (iii) R 3 and R 4 are independently unsubstituted Cs-C-is alkyl; and the amine oxide is of the formula R R2R3NO, as defined above, preferably a C12-14 alkyl dimethylamine oxide.
In addition, the composition or cleaning agent may in certain embodiments comprise additional non-ionic surfactants, i.e. non-ionic surfactants other than amine oxide, such as a non-ionic surfactant selected from the group consisting of poly alkoxylates, alkoxylated fatty alcohols, alkoxylated fatty acids, alkoxylated alkylphenols and block copolymers of ethylene oxide and propylene oxide. However, in preferred embodiments, the composition does not contain any non- ionic surfactant other than the amine oxide.
The disinfectant composition of the invention can be comprised in a cleaning agent, as described above, and said cleaning agent or the disinfectant composition itself can additionally comprise one or more components that are commonly used in cleaning agents, for example those selected from the group consisting of additional disinfectants, cellulosic thickeners, viscosity regulators, dyes, perfumes, preservatives, water/stain repellents, stain release agents, refreshing agents, biocidal agents, anti-microbial agents, disinfecting agents, malodor control agents, abrasion resistance and protection agents, solvents such as water or non-aqueous solvents, insect/pet repellents, wetting agents, UV protection agents, enzymes, bleaching systems, antistats and mixtures thereof.
Additional biocidal agents, anti-microbial agents and/or disinfecting agents that can be used in the disinfectant compositions described herein include, without being limited thereto, amines, quaternary ammonium compounds, aldehydes, antimicrobial acids and salts thereof, carboxylic acid esters, acid amides, phenols, phenol derivatives, diphenyls, diphenylalkanes, urea derivatives, oxygen acetals, oxygen formals, nitrogen acetals, nitrogen formals, benzamidines, isothiazolines, phthalimide derivatives, pyridine derivatives, guanidines, quinolines, iodine, iodophores, halogen compounds and mixtures thereof. These compounds act effectively against viruses, bacteria, moulds or yeasts. Exemplary biocidal compounds that may be used include, without limitation, 1 ,2- dibromo-2,4-dicyanobutane, iodo-2-propylbutyl carbamate, undecylenic acid, salicylic acid, dihydroacetic acid, o-phenylphenol, N-methylmorpholinoacetonitrile (MMA), 2-benzyl-4- chlorophenol, 2,2'-methylenebis(6-bromo-4-chlorophenol), 4,4'-dichloro-2'-hydroxydiphenyl ether (diclosan), 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), chlorhexidine, N-(4-chlorophenyl)-N- (3,4-dichlorophenyl)urea, N,N'-(1 ,10-decanediyldi-1-pyridinyl-4-ylidene)-bis(1-octanamine) dihydrochloride, N,N'-bis(4-chlorophenyl)-3, 12-diimino-2,4, 1 1 , 13-tetraazatetradecanediimidamide, glucoprotamines, guanidines including the bi- and polyguanidines, such as e.g. 1 ,6-bis(2- ethylhexylbiguanidohexane) dihydrochloride, 1 ,6-di-(Ni ,Ni'-phenyldiguanido-N5,Ns')hexane tetrahydrochloride, 1 ,6-di-(Ni ,Ni'-phenyl-Ni ,Ni-methyldiguanido-N5,N5')hexane dihydrochloride, 1 ,6-di-(Ni ,Ni'-o-chlorophenyldiguanido-N5, N5 )hexane dihydrochloride, 1 ,6-di(Ni ,Ni'-2,6- dichlorophenyldiguanido-N5,N5 )hexane dihydrochloride, 1 ,6-di-[Ni ,Ni'-beta-(p-methoxy- phenyl)diguanido-N5, N5']hexane dihydrochloride, 1 ,6-di-(Ni ,Ni'-alpha-methyl-beta.- phenyldiguanido-N5, N5')hexane dihydrochloride, 1 ,6-di-(Ni ,Ni'-p-nitrophenyldiguanido- N5,N5')hexane dihydrochloride, omega:omega-di-(Ni ,Ni'-phenyldiguanido-N5, N5')-di-n-propyl ether dihydrochloride, omega:omega'-di-(Ni ,Ni'-p-chlorophenyldiguanido-N5, N5')-di-n-propyl ether tetrahydrochloride, 1 ,6-di-(Ni ,Ni'-2,4-dichlorophenyldiguanido-N5,N5')hexane tetrahydrochloride, 1 ,6-di- (Ni ,Ni'-p-methylphenyldiguanido-N5,N5')hexane dihydrochloride, 1 ,6-di-(Ni ,Ni'-2,4,5- trichlorophenyldiguanido-N5, N5')hexane tetrahydrochloride, 1 ,6-di-[Ni ,Ni'-alpha-(p-chlorophenyl) ethyldiguanido-N5,N5']hexane dihydrochloride, omega:omega-di-(Ni ,Ni'-p-chlorophenyldiguanido- N5,N5')m-xylyl dihydrochloride, 1 ,12-di-(Ni ,Ni'-p-chlorophenyldiguanido-N5,N5')dodecane dihydrochloride, 1 , 10-di-(Ni ,Ni'-phenyldiguanido-N5,N5')decane tetrahydrochloride, 1 , 12-di-(Ni ,Ni'-
phenyldiguanido-N5, N5')dodecane tetrahydrochloride, 1 ,6-di-(Ni ,Ni'-o-chlorophenyldiguanido- N5,N5')hexane dihydrochloride, 1 ,6-di-(Ni ,Ni'-o-chlorophenyldiguanido-N5,N5')hexane tetrahydrochloride, ethylenebis(l-tolylbiguanide), ethylenebis(p-tolylbiguanide), ethylenebis(3,5- dimethylphenylbiguanide), ethylenebis(p-tert-amylphenylbiguanide), ethylenebis(nonyl- phenylbiguanide), ethylenebis(phenylbiguanide), ethylenebis(N-butylphenylbiguanide), ethylenebis(2,5-diethoxyphenylbiguanide), ethylenebis(2,4-dimethylphenylbiguanide), ethylenebis(o-diphenylbiguanide), N-butyl ethylene-bis(phenylbiguanide), trimethylenebis(o- tolylbiguanide), N-butyl trimethylene-bis(phenylbiguanide) and the corresponding salts such as acetates, gluconates, hydrochlorides, hydrobromides, citrates, bisulfites, fluorides, polymaleates, N-cocoalkyl sarcosinates, phosphites, hypophosphites, perfluorooctanoates, silicates, sorbates, salicylates, maleates, tartrates, fumarates, ethylenediamine tetraacetates, imino diacetates, cinnamates, thiocyanates, arginates, pyromellitates, tetracarboxybutyrates, benzoates, glutarates, monofluorophosphates and perfluoropropionates as well as any mixtures thereof. Also suitable are halogenated xylene and cresol derivatives, such as p-chlorometacresol or p-chlorometaxylene.
However, in a preferred embodiment of the inventive disinfectant solution, the cationic surfactant is a quaternary ammonium compound and this quaternary ammonium compound at the same time also represents the disinfecting agent, i.e. the active disinfectant.
In various embodiments of the present invention, the cellulosic thickener is selected from the group consisting of cellulose, carboxymethyl cellulose or the sodium salt thereof, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, cellulose acetate and mixtures thereof. Preferred thickeners include hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, and hydroxyethyl methyl cellulose, in particular hydroxyethyl cellulose. Suitable cellulosic thickeners are commercially available from a variety of sources, for example as Cellosize QP 100 MH from Dow Chemicals, as Benecel MP 333 C, Culminal MC 2000 S and Culminal MHPC 3000 from Hercules, and MHEC 5000 PR and MHPC 600 R from Henkel.
The inventive disinfectant composition may be a liquid disinfectant composition.
The disinfectant composition of the invention can be an aqueous composition and can, in various embodiments, comprise at least 50 wt.% water, preferably at least 70 wt.% water or more.
In another embodiment, the composition additionally contains non-aqueous solvents for example selected from the group of monohydric or polyhydric alcohols, alkanolamines or glycol ethers, provided that they are miscible with water in the concentration range given. The solvents are preferably selected from ethanol, n- or i-propanol, butanols, glycol, propanediol or butanediol, glycerol, diglycol, propyl or butyl diglycol, hexylene glycol, ethylene glycol methyl ether, ethylene
glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol mono-n-butyl ether, diethylene glycol methyl ether, diethylene glycol ethyl ether, propylene glycol methyl, ethyl or propyl ether, dipropylene glycol monomethyl or ethyl ether, di-isopropylene glycol monomethyl or ethyl ether, methoxy, ethoxy or butoxy triglycol, 1-butoxyethoxy-2-propanol, 3-methyl-3-methoxybutanol, propylene glycol t-butyl ether and mixtures of these solvents. Non-aqueous solvents can be used in quantities of between 0.5 and 15 wt.%, but preferably less than 9 wt.% and in particular less than 5 wt.%.
In one embodiment, the disinfectant composition comprises 0.5 to 5, preferably 0.5 to 2.5 wt.% ethanol and/or isopropanol. Ethanol and isopropanol also possess an antimicrobial activity and thus extend the spectrum of action of the disinfectant composition.
In a preferred embodiment, the disinfectant composition comprises a perfume composition in a quantity of usually up to 2 wt.%, preferably 0.01 to 1 wt.%, particularly 0.02 to 0.75 wt.% and particularly preferably 0.04 to 0.4 wt.%.
The perfume composition can contain individual fragrance compounds, for example the synthetic products of the type of the esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Preferably, however, mixtures of various fragrances are used which together produce an attractive scent. The perfume composition can also contain natural fragrance compounds as may be obtained from plant sources.
In order to bring the pH of the composition into the desired range, the use of pH adjusters may be indicated. All known acids or lyes may be used here, provided that their use is not prohibited for reasons of application technology or on ecological grounds, or for reasons of consumer protection.
To improve the aesthetic impression of the compositions, they can be colored using suitable dyes. Preferred dyes, the selection of which offers no problem to the person skilled in the art, possess high storage stability and are not sensitive to the other ingredients of the composition and to light.
As already stated above, the disinfectant composition may be part of a cleaning agent, the cleaning agent also being encompassed by the present invention. Thus, all embodiments described above in relation to the disinfectant composition similarly apply to the cleaning agents of the invention and vice versa.
The invention also relates to the use of the disinfectant composition or cleaning agent according to the invention for cleaning and/or sanitizing an object, preferably a hard surface. The cleaning and/or sanitizing includes reducing the number of microorganisms on the object or hard surface
treated therewith. Alternatively, the composition or agent according to the invention may be used to reduce the number of microorganisms in a washing or rinsing solution.
Also encompassed by the present invention is a method for cleaning and/or sanitizing an object, preferably a hard surface, the method comprising contacting said object with a disinfectant composition or a cleaning agent according to the invention. The contacting may be done by pouring, spraying or otherwise wetting the object, preferably a hard surface, with the composition or agent of the invention. The composition may for example be applied to an object by rubbing it with a brush, sponge or cloth wetted with the composition.
Example
The following compositions according to table 1 were prepared by mixing the components in water and adjusting the final pH value with citric acid. All amounts given in table 1 are wt.% if not otherwise noted.
Table 1 :
1 Cocoalkyl dimethyl benzyl ammonium chloride (50 wt.% active matter in water) (Thor)
2 Ethoxylated C6-fatty alcohol with 5 moles of ethyleneoxide (95 wt.% active matter; 5 wt.% Ethylenglykolmonohexylether) (BASF SE)
3 Ethoxylated Ci2-is-fatty alcohol with 7 moles of ethyleneoxide (Galaxy Surfactants Ltd.)
4 Amines, alkyldimethyl, N-oxides (C12-14 dimethylamine oxide; 30 wt.% active matter in water) (Clariant)
The cleaning performance and foam profile of all non-ionic surfactants listed above were analyzed in a disinfectant formula. The composition comprising 0.3, 0.4 or 0.5 wt.% amine oxide did not only show a great improvement in cleaning performance, but also exhibited the best foam profile in hard and soft water. Moreover, it allows for a much more sustainable formula as a lower dose of chemical is necessary.
This method involved wiping a white dirt carrier treated with test dirt with a sponge soaked in the test specimen under defined conditions. The cleaning capacity is measured photoelectrically against the untreated white dirt carrier (= 100% degree of whiteness). The main features of the test method were published in 1986 as IPP quality standards in the journal "Seifen-Ole-Fette-Wachse" (Soaps-oils-greases-waxes), 1 12th volume, number 10, pages 371 -372.
Production of the test dirt:
Reagents:
Oil V. Myritol® 318 (BASF)
Oil 2: Nytex® 801 (Nynas)
Gasoline 80/1 10® (Roth)
Soot: Special black 4® (EVONIK)
The production of 600 g of test dirt was performed as follows:
102 g Myritol 318 (= 17%), 240 g Nytex 801 (= 40%) and 216 g gasoline 80/1 10 (=
36%) were placed in a 1000 ml wide-mouth screw-top jar and stirred for 1 min. Slowly 42 g soot (=7%) (within 3 min) was added. Then the dirt was stirred for 60 min at 2000 rpm, and topped up with the missing gasoline. Finally, the solution was stirred thoroughly for 15 s.
Production of the dirt carriers
Reagents:
Adhesive Adhesin J1626-21 (Henkel)
Devices:
white PVC-foil BENOVA, 50 x 1.30 m; supplier Benecke GmbH, P.O. Box 709, Hanover, Order number 221 1 18,
Cardboard strips (554 x 39 mm), the lengths must run in the direction of the fiber: Only hansa board 400 g/m2, smooth on one side, white, without barrier layer; Stora (formerly Feldmuhle AG), Dusseldorf, Work surface e.g. PVC, 1000 x 500 x 5 mm,
To improve the brushability, the adhesive was diluted with 30 g of demineralized water per 1000 g adhesive. The cut foil sheets were used with approximate dimensions of 650 x 300 to 400mm. This measurement resulted from the roll width of 1300 mm and the width for 7 x 39 mm wide strips plus seam allowance. Halve the roll width so that a 554 mm long cardboard strip fit onto a half roll width of 650 mm.
The foil was laid on the work surface with the smooth side down (this smooth side was later be soiled). The smooth side was determined by turning down a lying foil strip (approx. 30 x 10 cm) so that one third of its bottom side faces upward. A line was made with a red felt-tip marker lengthwise across the foil beginning at the double layer and ending at the single layer. On one
piece a weaker coloration on which elevations are clearly recognizable were noted (= coarse). The ink was richly applied on the other piece (= smooth).
By means of a paint roller for radiators an even thin coating of adhesive was applied. Then seven cardboard strips with approx. 1 mm clearance were laid between them (the smooth white side facing the foil). Most of the air bubbles were pressed out by wiping vigorously with a fist-sized pulp bale in the lengthwise direction of the strips; the remaining bubbles were receded within the 24 hours time period of drying the adhesive.
The foil was cleanly cut off by protruding beyond the edges of the plate with a foil cutter.
The plates prepared in this way were stacked for storage - and always with foil-on-foil and cardboard-on-cardboard - with the whole surface weighted, so that they stayed flat.
Soiling of the dirt carriers: Reagents:
Test dirt: Homogenize for approx. 15 min with a magnetic stirrer before applying.
Devices:
Flat lacquer brush with natural bristles, approx. 55 mm wide, glued in the holes of the twist-off caps (see below),
370 ml jars fitting the twist-off caps,
Watch glasses (80 mm 0) for weighing the respective test dirt,
125 ml wide-mouth screw-lid jars containing the respective test dirt,
Foil cutter,
Template of 3 mm thick PVC, 550 x 400 mm with interior cutout of 260 x 300 mm, Scale (sensitivity 0.01 g), e.g. Sartorius
The dirt carrier plate (foil facing upwards) was covered with the template, making soiling possible in the lengthwise direction of 260 mm and of the entire 280 mm width. A quantity of 2.0 g of test dirt was weighed on a watch glass. If a new brush was used, it was saturated in the test dirt for 24 hours, subsequently squeezed and brushed onto the foil until no more dirt dripped off. Then the soiled brush was stored in a screw-top jar until usage.
Priming
The corresponding amount of soiling was coarsely spread on the dirt carrier.
1st step:
After coarse distribution over the entire surface within the template, the dirt was spread in the lengthwise direction of the strips from the upper left to the upper right. The brush was moved to the left side and drawed a second track overlapping the first. This procedure was continued until the lower right corner was reached in this way.
2nd step:
The dirt was further worked in by guiding the brush from the upper left to the lower left and back again along the same track. It was proceeded track-by-track with overlapping until the brush stroke ended in the upper right.
3rd step:
Performed as described in "1st step". 4th step:
The dirt was worked in from top to bottom. The brush was guided in single tracks overlapping from left to right. After soiling, the foil was separated between the individual strips using a foil cutter. The stripes were then hung on a frame to be air-dried. The drying time was 1 h.
Three strips for every cleaning agent to be tested were soiled.
Cleaning process
Reagents:
soiled cardboard strips, prepared test solutions.
Devices:
Polyester sponge BULPREN S28/190 black (Euroform) length: 90 mm (± 3.0 mm); Width: 45 mm (± 1 .5 mm); Height: 30 mm (± 1.0 mm)
washability and abrasion tester 494 from Erichsen GmbH, D-58675 Hemer-Sundwig. Brass guide rail for the sponge cart, 554 mm in length, milled. Closed sponge cart which picks up the sponge from below, with weight attachment (820 g). The weight ensures even rolling of the sponge cart during wiping.
Disposable syringe for viscous products.
Preparation of the cleaning sponges
The dimensions and the water holding capacity checks after sgueezing the sponge were made on a random basis for each new sponge delivery. A new order from Euroform made by Purchasing comprises around 9000 sponges. The sponges were soaked in tap water shortly before the start of the test.
Immediately before the respective cleaning process, the individual sponge was sgueezed out under a stamp. This stamp was clamped in a drill stand and eased the sgueezing. Each sponge was used no more than only once.
Cleaning process:
The soiled cardboard strips were laid into the guide rails of the wiping device. The moist sgueezed sponge was laid into the sponge cart of the cart which lied on the top side. 6 mL of test detergent solution was applied via a syringe to the non-soiled area of the cardboard strip.
The cart was turned around so that the sponge rested on the strip in the guide rail and weighed it down. When turning around, it was ensured that possible dripping liguid lands on the strip. Then the wiping process was started. The sponge was wiped back and forth 10 times. Then the strip was removed from the rail and rinsed thoroughly at 20 °C with flowing tap water (before rinsing, the water should run for at least 10 min). The strip was guided diagonally downwards (angle approx. 45 °) under the water jet, so that the jet rinsed the dirt from top to bottom. The strips were hung to dry on a suitable frame for 1 hour.
Degree of whiteness measurement
Devices:
Konica-Minolta Chroma Meter CR-400 Measuring parameters: Color system: Y Standard illuminant: D65 without UV
The degree of whiteness was measured with the Konica-Minolta Chroma Meter CR-400. The measurement was taken against a white standard: Clean, untreated dirt carrier strips correspond to 100% RV (cleaning capacity). 7 measured values were determined from each of the 3 cleaned strips of a test specimen (corresponded to 21 measuring points per detergent) and the corresponding mean average values were calculated.
The experimental results of the cleansing power determination are as follows:
E1 E2 E3 V1
% dirt removal 38,9 39,3 39,9 32,6
Claims
1 . Disinfectant composition comprising:
(i) 0.3 to 1 .0, preferably 0.4 to 0.5 wt.% relative to the complete composition of amine oxide; and
(ii) at least one cationic surfactant,
wherein the composition has a pH value of 5-6.
2. The disinfectant composition of claim 1 , wherein the amine oxide has the general formula R R2R3NO, wherein each R , R2 und R3 independently from each other can be a Ci to C30 chain of carbon atoms, which is optionally substituted , preferably linear or branched saturated C1-30 alkyl, more preferably unsubstituted linear C1-20 alkyl.
3. The disinfectant composition of claim 2, wherein R and R2 are Ci-4 alkyl, preferably
unsubstituted C1-4 alkyl, more preferably methyl or ethyl, most preferably methyl, and R3 is Cs- 20 alkyl, preferably unsubstituted C8-20 alkyl, more preferably unsubstituted C10-18 alkyl, most preferably unsubstituted C12-16 alkyl.
4. The disinfectant composition of any one of claims 1 to 3, wherein the amine oxide is a C12-14 alkyl dimethylamine oxide.
5. The disinfectant composition of any one of claims 1 to 4, wherein the cationic surfactant is a quaternary ammonium compound (QAC), preferably a QAC of the general formula
(R )(R 2)(R 3)(R 4)N+X-, wherein each of R , R 2, R 3 and R 4 is independently linear or branched C1-C22 alkyl, C2-C22 alkenyl, C2-C22 alkynyl or C7-C28 alk(en)ylaryl that can optionally be substituted or any two or three of R , R 2, R 3 and R 4 combine to form a 5-6-membered , optionally aromatic, heterocyclic ring with the nitrogen atom to which they are attached; and X" is an anion.
6. The disinfectant composition of any one of claims 1 to 5, wherein the composition comprises 0.3 to 0.6, preferably 0.4 to 0.55 wt.% relative to the complete composition of the at least one cationic surfactant, preferably QAC.
7. The disinfectant composition of any one of claims 1 to 6, wherein the composition further comprises one or more additional components selected from the group consisting of further disinfectants, cellulosic thickeners, viscosity regulators, dyes, perfumes, preservatives, water/stain repellents, stain release agents, refreshing agents, biocidal agents, anti-microbial agents, disinfecting agents, malodor control agents, abrasion resistance and protection agents, solvents, insect/pet repellents, wetting agents, UV protection agents , enzymes, bleaching systems, antistats and mixtures thereof.
8. Liquid cleaning agent comprising the disinfectant composition of any one of claims 1 to 7.
9. Use of the disinfectant composition of any one of claims 1 to 7 or the cleaning agent of claim 8 for cleaning and/or sanitizing an object, preferably a hard surface.
10. Method for cleaning and/or sanitizing an object, preferably a hard surface, comprising contacting said object with a disinfectant composition of any one of claims 1 to 7 or the cleaning agent of claim 8.
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WO2017011158A1 (en) | 2015-07-14 | 2017-01-19 | Ecolab Usa Inc. | Controlled rate of foam breakage in hard surface cleaners |
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