WO2015090320A2 - Dose delivery device with improved handling - Google Patents

Dose delivery device with improved handling Download PDF

Info

Publication number
WO2015090320A2
WO2015090320A2 PCT/DK2014/000056 DK2014000056W WO2015090320A2 WO 2015090320 A2 WO2015090320 A2 WO 2015090320A2 DK 2014000056 W DK2014000056 W DK 2014000056W WO 2015090320 A2 WO2015090320 A2 WO 2015090320A2
Authority
WO
WIPO (PCT)
Prior art keywords
dose
cartridge
housing
needle
cover
Prior art date
Application number
PCT/DK2014/000056
Other languages
French (fr)
Other versions
WO2015090320A3 (en
Inventor
Claus Schmidt MØLLER
Original Assignee
Cpu Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cpu Innovation filed Critical Cpu Innovation
Publication of WO2015090320A2 publication Critical patent/WO2015090320A2/en
Publication of WO2015090320A3 publication Critical patent/WO2015090320A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3271—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position

Definitions

  • the invention relates to a dose delivery device wherein a dose can be set by rotating a dose-setting member, and by which rotation of the dose-setting member to set a dose loads a spring, and by which actuation of a release feature releases the applied spring force, which drives a screw forward co-operating with a piston in a cartridge and expelling a medicament out of the cartridge through a needle.
  • WO2006045528 describes a pen with a torsional spring operatively connected to a dose-setting member.
  • a rotationally arranged display member is connected to the spring via a driver, and is adapted to display the dose to be expelled set by rotation of the dose-setting member.
  • the movement of the rotationally arranged display member is following a helical path and is adapted to be rotated over an angle corresponding to one or more revolutions, so that the endpoints of the angle defines the maximum dose to be set, and the "end of dose” positions.
  • WO2006045529 describes a device based on a push-spring, which has a mechanical display member with helical arranged numbers, and which is capable of rotating more than one revolution.
  • a screw is engaged with a housing via a thread.
  • a nut which is rotationally coupled to the numbered display member, is engaging the same thread on the screw, and between the nut and the display member a push-spring is arranged.
  • An index feature which indexes the dose setting at specific amounts of medicament to be injected, is rotationally locked to the screw.
  • a locking feature is rotationally but not axially locked to the screw, and this locking feature is further more connected to a release feature, which by operation of a user can set the locking feature free to rotate.
  • the release feature is operated perpendicular to the axis of the device and close to the needle. Rotating the numbered display member by means of a dose selector, which in turn rotates the nut and compresses the spring, sets a dose.
  • a dose selector which in turn rotates the nut and compresses the spring
  • sets a dose When the release feature is operated, and the locking nut is set free to rotate, the screw, the nut, the display member and the index feature rotates as well because of the force arising from the push-spring and the non self locking thread engagement between the screw and the housing.
  • the user interface is not very well suited for injections in awkward positions.
  • WO2011060786 describes a device based on a push- spring but with a push-button in the end.
  • a screw is engaging a housing via a thread
  • a nut which is rotationally coupled to a dose member, is engaging the thread on the screw as well.
  • a push-spring is arranged between the nut and the dose member.
  • a non-axial moving one-way ratchet is rotationally coupled to the screw and ensures that the screw can only move forward.
  • the dose member can either be provided with helically arranged numbers printed on the outside, or an external display member can be present. This configuration can also be difficult to use in awkward positions and areas of the body.
  • WO20131 10538 describes a device with helically arranged numbers on a dose member, which rotates in one direction when a dose is set, and in the opposite direction when the set dose is injected, and which does not move axially.
  • a sliding window which moves axially in an opening in the housing, is provided.
  • the invention relates to a mainly cylindrical dose delivery device defining a main axis and comprising a housing,
  • a dose can be set by rotating the dose-setting member relative to the housing, and whereby the first dose member follows the rotation of the dose-setting member during the setting of the dose, and wherein the window does not rotate relative to the housing, and wherein, during rotation of the first dose member, the num- bers printed on the first dose member are visible one by one through the window, characterized by that during rotation of the first dose member the relative movement between the first dose member and the window is following a path defined by a sequence of circular and not circular movements.
  • the numbers which are indicating the size of a set dose, can be printed on an element of the device in a more compact way and requiring less axial movement of the element relative to the window through which it is displayed.
  • the path is defined by tracks on the first dose member, and a key on the sliding window engages the tracks one at the time. This makes it possible to let the ends of the track chain define the zero position stop and the max dose stop.
  • the first dose member does not move axial relative to the housing when it rotates, and during rotation of the first dose member the window moves axial relative to the housing over a first angle of the first dose member, and the window does not move axial over a second angle of the first dose member de- fined by the remaining angle of a full revolution, the second angle being larger than the first angle.
  • the relative movement between the first dose member and the window pulses, it is an advantage to let the window slider move relative to the housing instead of the first dose member, as the window has a much lower mass.
  • an area on the window comprises a magnifier that enlarges the numbers, which are visible through the window. It is an advantage and very easy to build in a magnifier in the window, as this does not require an extra part and as it will increase the readability of the numbers.
  • the dose delivery device further comprises: a driver rotationally coupled to the first dose member,
  • a ratchet between the screw 8 and the housing, wherein the ratchet only allows the screw to rotate in a direction, which pushes the piston into the cartridge so that medicament are expelled out through a needle, and wherein, during dose setting, the driver is rotated in the blocked direction of the screw, whereby it is moved away from the cartridge, and wherein, during injection, the first dose member is rotationally coupled to the screw. In this way the rotational movement of the screw is transferred to the first dose element, and the first dose element does not have to carry a thread engagement with any elements of the device.
  • the dose delivery device further comprises: a trigger sleeve arranged coaxial with the housing,
  • indexing means indexing the first dose member relative to the housing at equally spaced positions around the revolution, wherein during dose setting the rotation of the driver is against the bias of the spring, and wherein rotation of the driver further tense the spring, and wherein the indexing means are strong enough to prevent the first dose member from rotating due to the spring force from the spring, and wherein axial movement of the trigger sleeve rela- tive to the housing disengage the indexing means.
  • the steep non self locking thread angle in the thread connection between the housing and the screw is utilized to rotate the screw and the first dose member during injection, because the spring force acts on both the driver and the screw as they are locked together during injection.
  • a dose delivery device comprises: a housing,
  • a cartridge holder fixed in the housing and containing a medicament filled cartridge, a needle attached to the cartridge holder,
  • a needle cover arranged coaxially with and between the cartridge holder and the cartridge cover, wherein the cartridge holder and the cartridge cover has elongated openings, which at a first rotational position of the cartridge cover are unaligned, whereby the cartridge in the cartridge holder is not visible, and which at a second rotational position of the cartridge cover are aligned, whereby the cartridge in the cartridge holder is visible, characterized by when the cartridge cover is in the first rotational position the needle cover is locked in a position where the needle is inaccessible for injection, and when the cartridge cover is in the second rotational position, the needle is accessible for injection.
  • the needle cover when the cartridge cover is in the second rotational position, the needle cover is displaced axially and locked in a position where the needle is exposed through a hole in the end of the needle cover.
  • This embodiment exposes the needle in just one movement of the cartridge cover, and makes it easy for a user to see and follow the insertion of the needle.
  • the needle cover when the cartridge cover is in the second rotational position, the needle cover is unlocked and axially displaceable against the bias of a spring, whereby the needle is exposed through a hole in the needle cover.
  • the dose delivery device further comprises: a trigger for injecting a set dose, and, when the cartridge cover is in the first rotational position, the trigger is locked to prevent a set dose to be injected, and wherein, when the cartridge cover is in the se- cond rotational position, the trigger can be operated to inject a set dose.
  • a trigger for injecting a set dose and, when the cartridge cover is in the first rotational position, the trigger is locked to prevent a set dose to be injected, and wherein, when the cartridge cover is in the se- cond rotational position, the trigger can be operated to inject a set dose.
  • an injection device comprising a housing and a cartridge with the medicament to be injected.
  • a linear push spring is adapted to be preloaded between a driver engaged with a screw via a thread and a first dose member, the driver and the first dose member are rotationally but not axially coupled and the first dose member has numbers printed on the outer cylindrical surface.
  • the screw which is also engaging the housing via the thread, has one or more longitudinally tracks and is rotationally coupled to a one-way ratchet, which is axially fixed relative to the housing, and which only allows rotation in one direction.
  • the first dose member also comprises a two-way ratchet which interacts with the housing, and which allows it to be rotated in both directions and to be indexed at certain positions around the revolution corresponding to specific amounts of medica- ment to be injected.
  • the click torque is of a size big enough to hold against the torque, which attempts to rotate the dose-setting member back to zero position and which arises from the thread engagement between the screw and the housing.
  • a trigger sleeve is surrounding the housing and is rotationally fixed to the housing and axially fixed to the dose-setting member.
  • the first dose member connects rotationally to the second dose member, and therefore also the second dose member and, due to the rotational coupling, the screw will rotate, which in turn will drive the screw and the driver forward, due to the thread engagement between the screw and the housing, and the screw advances into the cartridge.
  • the advancement of the screw will expel the medicament due to a co-operation with a piston in the medicament filled cartridge.
  • the numbers printed on the first dose member can be viewed through a transparent area in a window movable in an opening in the housing.
  • the numbers are arranged in circles above each other and around the outer surface of the first dose member.
  • the window is adapted to move axially in the opening in the housing, such that when the all numbers in one circle has been displayed one by one through the window, the window will move up in the device and allow the numbers of the next circle to be displayed and so on.
  • the movable window is engaging a track in the first dose mem- ber, which controls the axial position of the window.
  • the numbers are printed on a scale drum and relative axial movement between the window and the scale drum can be obtained by axial movements of both the window and the scale drum, or solely by axial movement of the scale drum.
  • the cartridge with the medicament is contained in a cartridge holder, which is fixed to the housing.
  • the cartridge holder has elongated windows, which allows a user to inspect the content of the cartridge.
  • a tube formed cartridge cover also comprising two elongated windows is arranged coaxial with the cartridge holder, and the cartridge cover can either be in a rotational position where the windows of the cartridge holder and the cartridge cover are aligned, and inspection of the cartridge content is possible, or in a rotational position where the windows are not aligned, and the cartridge is fully covered by the cartridge holder and the cartridge cover.
  • a needle cover is arranged in the end of the device. By rotation of the cartridge cover to the open position, which allows inspection, the needle cover is retracted to a position where the needle is free to be inserted.
  • the needle cover has an opening in the end to allow the needle to be exposed, and the needle cap on the needle to be removed.
  • the cartridge cover is indexed in one of two rotational positions by a spring, and the cartridge cover and the needle cover can be removed from the device, when it is desired e.g. if the cartridge must be replaced.
  • the first dose member can be arranged to provide a clicking sound against the housing when a set dose is injected.
  • An advantage by using the first dose member is, that it always ends in the same position, and it is therefore possible to configure different sounds at certain intervals, e.g. at 0,10,20 units, by changing the height or width of the relevant teeth.
  • Figure 1 shows a perspective view of a pen according to the invention
  • Figure 2 shows an exploded view of the pen according to the invention
  • Figure 3 schematically shows a vertical sectional view of a pen according to the invention ready to set a dose
  • Figure 4 schematically shows a vertical sectional view of a pen according to the invention where a dose has been set.
  • Figure 5 schematically shows a vertical sectional view of a pen according to the invention where a dose has been injected and the trigger sleeve is still activated
  • Figure 6 shows an exploded and partly sectional view of the number display mechanism
  • Figure 7 shows a perspective view of the sliding window
  • Figure 8 shows a perspective view of the scale drum
  • Figure 9 schematically shows a vertical sectional view of a pen according to the invention where the cartridge and needle cover mechanism is visible in close position
  • Figure 10 shows an exploded view of the cartridge and needle cover mechanism
  • Figure 1 1 shows a perspective view of the cartridge and needle cover mechanism in closed position
  • Figure 12 shows a perspective view of the cartridge and needle cover mecha- nism in open position
  • main axis defines the common axis of revolution for the mainly tube shaped parts and for the entire injection device. Only the parts necessary to understand the function is included in the description, however, the drawings may show other parts, which could be part of an injection device comprising the feature.
  • the terms “up” and “down” and “upper” and “lower” and “upward” and “downward” refer to the drawings and does not necessarily correspond to a situation of use.
  • the described screw is abutting a plunger in a medicine filled cartridge and downward movement of the screw moves the plunger in the cartridge and medicine is pressed out through s needle. Plunger, cartridge and needle are not shown on all drawings.
  • a perspective view of a device according to the invention can be seen.
  • a dose-setting member 3 by which a dose can be set by rotating the dose-setting member 3 clockwise and corrected downward by rotating the dose-setting member 3 anticlockwise, can be seen.
  • a trigger sleeve 5 by which a set dose is injected, is visible.
  • the trigger sleeve 5 is axial connected to the dose- setting member 3, and a set dose is injected by gripping around the trigger sleeve and pressing the needle end of the device with the needle inserted against the skin.
  • the cartridge cover 12 with a window 51 and the needle cov- er 13 can be seen.
  • the device is prepared for injection by rotating the cartridge cover 12 an angle. This will align the window 51 in the cartridge cover 12 with a corresponding window 49 in a cartridge holder 1 1 inside the cartridge cover, and the content of the cartridge contained in the cartridge holder 1 1 will be visible. Rotation of the cartridge cover 12 further more retracts the needle cover 13 into the device and the needle becomes accessible. This will be further explained.
  • Fig. 2 shows an exploded view of a device according to the invention with all elements of the device visible. These will be referred to during the functional descriptions, especially when the sectional views do not clearly show the described feature.
  • FIG. 3 the dose setting and injection mechanism of a device according to the invention, can be seen.
  • a nut 7 comprising a threaded hole 39 is fixed to the housing 1.
  • a screw 8 has a thread 42 along the entire length of the screw 8 and is engaging the thread 39 of the nut 7, however, the thread 42 has a top in the upper end of the screw 8 to prevent the screw 8 from rotating out of the nut 7 and to prevent the user from being able to set a dose, which is higher than the remaining content of the cartridge. This will be further explained later.
  • the screw 8 has two flat sides, which allows it to be rotationally but not axially coupled to a one-way ratchet comprising a rotational coupling part 9 and a ratchet part 10 having two ratchet arm 45, which cooperates with teeth in the nut 7.
  • the one-way ratchet assembly 9/10 en- sures that the screw 8 can only move towards the needle, but as the part is assembled by two items 9/10 with a second ratchet between them, the user is actually able to rotate the screw 8 back into the device against a substantial torque, when the cartridge is replaced and the device is reloaded.
  • the one-way ratchet is axially but not rotationally fixed in the nut 7.
  • a driver 6 is also engaged with the thread 42 on the screw 8 by a thread 37.
  • the driver 6 is further rotational but not axial connected to a first dose member 2 by means of keys 38 on the driver 6 and grooves 30 on the first dose member 2, which can clearly be seen in fig. 2, and further the first dose member 2 is releasable rotational connected to the dose-setting member 3 by means of a re- leasable teeth connection 28/34 between the first dose member and a second dose member 4, to which the dose-setting member 3 is rotational but not axial connected, and which second dose member 4 is axial but not rotational connected to the housing 1.
  • a push-spring 15 is arranged inside the driver 6 and the first dose member 2 .
  • a pretensed push- spring 16 is arranged in such a way that it applies a force to the driver 6 in the downward direction.
  • the first dose member 2 is engaging the housing 1 in a two-way ratchet connection consisting of teeth 27 on the first dose member 2 cooperating with grooves 19 in the housing 1.
  • the first dose member 2 is capable of moving a small distance down in the device against the bias of the push-spring 15, which will in turn disconnect the two-way ratchet between the first dose member 2 and the housing 1 , and set the first dose member 2 free to rotate.
  • a recess in the housing 1 and a sliding surface on the first connecting member 2 prevents the first dose member 2 from moving up in the device due to the spring force.
  • the first dose member 2 also comprises teeth 29, which during injection will engage the first dose member 2 with the ratchet assembly 9/10 by means of cooperating teeth 43 on the rotational coupling part 9 and thereby the first connecting part 2 is locked to the screw 8.
  • the first dose member 2 has further more printed numbers on the outside cylindrical surface, which is visible through an opening in the housing 18 and a transparent area 60 in a movable window 22. This will be further explained later.
  • the thread 42 on the screw 8 has a stop in the upper end.
  • the stop in the thread 42 will abut the end of the thread segments 37 in the driver 6, and further dose setting is prevented.
  • a trigger sleeve 5 is arranged coaxial with the housing 1.
  • the trigger sleeve 5 is rotational connected to the housing 1 via grooves in the trigger sleeve 5 engaged with keys 20 on the outside surface of the housing 1 , which in turn allows the trigger sleeve 5 to move axial a small distance relative to the housing 1.
  • the trigger sleeve 5 is also axially but not rotationally locked to the dose-setting member 3 via a recess 36 inside the trigger sleeve 5 engaging flaps 31 on the dose-setting member 3.
  • FIG. 3 shows a device according to the invention where a dose has not yet been set, and it is clear that the first dose member 2 and the ratchet assembly 9/10 are disengaged, while on the other hand the first dose member 2 is engaging the housing 1 in the two-way ratchet connection 19/27, and the second dose member 4 in the teeth connection 28/34 (see fig. 2).
  • the driver 6 is in the zero position close to the ratchet assembly 9/10.
  • the driver 6 has moved up in the device, and away from the ratchet assembly 9/10, and as none of the first dose member 2 and the driver 6 are able to rotate relative to the nut 7 fixed in the housing 1 , there is no torque applied to the screw 8.
  • the spring force arising from the push- spring 15 is acting on the thread connection 39/42 between the screw 8 and the nut 7, and on the thread connection 37/42 between the screw 8 and the driver 6, and the screw 8 is in balance.
  • the trigger sleeve 5 When the user hereafter continues to press the device against the skin, the trigger sleeve 5 will begin to move axial relative to the housing 1 and against the force of the push-spring 15 and because of the axial connection between the dose-setting member 3 and the trigger sleeve 5, the dose-setting member 3 moves too.
  • the force required to inject a set dose is ra- ther high, the force of the push-spring 15 must be rather high, and therefore a return spring 16 applying a force to the dose-setting member 3 in the opposite direction is arranged between a shelf 59 on the dose-setting member 3 and protrusions 32 on the second dose member 4.
  • the return spring 16 is pretensed to a level, which results in a low and convenient trigger force when a user triggers the injection by pressing the device against the skin.
  • the dose-setting member 3 is mating the first dose member 2 in a sliding surface 58 on a very little diameter, and therefore the first dose member 2 is pushed down as well. This disengages the two-way ratchet 27 from the teeth 19 in the housing 1 and the teeth 28 from the teeth 34 on the second dose member 4, and the first dose mem- ber 2 is set free to rotate.
  • the first dose member 2 rotates clockwise when a dose is set to be higher, and anticlockwise when a dose is reset to be lower or when a set dose is injected, and therefore numbers can be printed on the first dose member 2 to display the size of a set or remaining dose through an opening 18 in the housing 1.
  • the first dose member 2 does not move axially relative to the housing 1 except from the limited triggering displacement, and therefore the numbers cannot be printed on a helical track and shown one after another in a fixed window in the housing 1.
  • a movable window 22 with a transparent area 60 is capable of sliding up and down in the opening 18 in the housing 1 , and is displaying numbers on one row after another, such that during dose setting, when all numbers in one circle have been shown, the window 22 moves axially to the next circle and displays the numbers in the circle one by one during the continued dose setting.
  • the sliding window 22 has a protrusion 57, which engage a combination of circular tracks 25 and slanted tracks 26 on the first dose member 2.
  • the angle of the slanted tracks 26 forms a not axially self-locking connection with the protrusion 57 on the movable window 22, such that when the protrusion 57 is in the slanted track 26, then relative rotation between the parts will cause the window 22 to move axially relative to the first dose member 2, and such that this axial movement will cause the window 22 to shift to the next circular track 25.
  • the numbers are printed on a scale drum 67 (see fig. 8) and relative axial movement between the window 22 and the scale drum 67 can be obtained by axial movements of both the window 22 and the scale drum 67, or solely by axial movement of the scale drum 67.
  • the scale drum 67 is rotationally connected to the first dose member 2 by ribs 68 engaging longitudinally track on the first dose member 2, and the circular and slanted tracks 69/70 on the scale drum 67 is engaging an inwardly protruding element on the window 22 or inside the housing 1.
  • the circular and slanted tracks 69/70 can also be in the housing 1 , or they can be partly in the housing 1 and on the scale drum 67.
  • a cartridge cover 12 Coaxial with the cartridge holder 1 1 a cartridge cover 12 is arranged and a needle cover 13 is connected with the cartridge cover 12 in such a way, that by rotation of the cartridge cover relative to the cartridge holder 1 1 the needle cover 13 retracts up in the cartridge cover 13 to be fully covered.
  • the needle cover 13 is rotationally locked to the cartridge cover 12 by means of keys 53 on the cartridge cover 12 and slots 55 on the needle cover 13.
  • An index spring 17 is provided between the cartridge holder 1 1 and the cartridge cover 12 to help indexing the cartridge cover 12 in an open and a closed position.
  • the cartridge holder 1 1 has a track 47, which cooperates with protrusions 50 in the cartridge cover 12.
  • the index spring 17 pushes the cartridge cover 12 towards the needle end and indexes the cartridge cover 12 in two rotational positions by pushing the key 50 in the cartridge cover 12 down in the groove 64 in the track 47 to set the cartridge cover 12 in the closed position, and down in the groove 63 to set the cartridge cover 12 in the open position.
  • the cartridge holder 1 1 has two windows 49, which extends along the axis of the part and opposite each other and each covering an angle of less than 90°, and the cartridge cover 12 has two corresponding windows 51. In the closed position the two sets of windows 49/51 are rotated 90° relative to each other, and in the open position, the windows are aligned and a user can inspect the content of the cartridge.
  • the track 47 on the cartridge holder 1 1 has an outlet 62, which allows a user to take off the.cartridge cover 12, e.g. to attach a new needle.
  • the grooves 63/64 has rounded edges such that the protrusion 50 in the cartridge cover 12 will jump up and down of the grooves just by rotation of the cartridge cover 12, while a user must press the cartridge holder 12 up and rotate to disengage the cartridge cover 12 from the cartridge holder 1 1 via the outlet 62. Due to the closed track 55 on the needle cover 13 the needle cover 13 cannot disengage from the cartridge cover 12, and the needle cover 13 will follow the cartridge cover 12, when it is mounted or disengaged from the cartridge holder 1 1.
  • the needle cover 13 Due to the key 53 in the cartridge cover 12 operating in the closed grooves 55 on the needle cover 13, the needle cover 13 can move axially in relation to the cartridge cover 12, but it cannot rotate.
  • the needle cover 13 has two protrusions 56 on the inner cylindrical surface which are engaging a helical track 48 on the cartridge holder 1 1, and consequently, when the cartridge cover 12 is rotated, the needle cover 13 will move up and down in the cartridge cover 12.
  • an arc formed area 65 is provided over an angle.
  • the protrusions 56 are positioned in the arc formed area 65 and the needle cover 13 is locked against axial movement.
  • the needle cover 13 does not move axially when the cartridge cover 12 is rotated, but instead rotation of the cartridge cover 12 unlocks and locks the needle cover 13, such that when the cartridge cover is in the open position, it is possible to press the needle cover up in the cartridge cover against the bias of a spring.
  • Fig. 1 1 shows the cartridge cover in the closed position, and it is clearly seen that the cartridge holder 1 1 is covering the windows 49 in the cartridge cover 12 and the cartridge contained in the cartridge holder 1 1 is hidden. It is also seen that the needle cover 13 totally covers the needle and makes it inaccessible.
  • the cartridge cover 12 has been rotated and indexed in the open position, and the windows 49 in the cartridge holder 1 1 are now aligned with the windows 51 in the cartridge cover 12, whereby it is possible to see and inspect the content of the cartridge (not shown).
  • the needle cover 13 has a hole in the closed end to allow the needle to be exposed, when the cartridge cover 12 is in its open position.
  • the cartridge cover 12 further more comprises two protrusions 66.
  • these protrusions prevent the trigger sleeve 5 from being pressed down and a set dose to be injected.
  • the cartridge cover 12 on the other hand is in its open position, the cut 61 in the trigger sleeve 5 can move over the protrusions 66, and the set dose can be injected.

Abstract

The invention relates to a dose delivery device wherein a dose can be set by rotating a dose-setting member 3, and by which rotation of the dose-setting member 3 loads a spring 15 when the dose is set, and by which the applied spring force is released by activation of a trigger 5 whereby the spring force drives a screw 8 co-operating with the piston in a cartridge forward and whereby a medicament thereby is expelled out of the cartridge through a needle. The dose delivery device according to the invention is characterized in that it comprises a dial 2 with numbers corresponding to a specific amount of medicament arranged in circles around the cylindrically surface of the dial, and displayed one by one through a window in the housing. The dose delivery device is further characterized in that it provides an improved way of preparing the device for injection and to inject the set dose.

Description

DOSE DELIVERY DEVICE WITH IMPROVED HANDLING
Field of invention
The invention relates to a dose delivery device wherein a dose can be set by rotating a dose-setting member, and by which rotation of the dose-setting member to set a dose loads a spring, and by which actuation of a release feature releases the applied spring force, which drives a screw forward co-operating with a piston in a cartridge and expelling a medicament out of the cartridge through a needle. Description of the related art
WO2006045528 describes a pen with a torsional spring operatively connected to a dose-setting member. A rotationally arranged display member is connected to the spring via a driver, and is adapted to display the dose to be expelled set by rotation of the dose-setting member. The movement of the rotationally arranged display member is following a helical path and is adapted to be rotated over an angle corresponding to one or more revolutions, so that the endpoints of the angle defines the maximum dose to be set, and the "end of dose" positions. When a push-button is depressed, the driver rotates a screw in a thread in the housing and the screw advances towards the needle end expelling the set dose. This has the advantage that the push-button only has to be moved a very little distance independent of the set dose, when the set dose is injected. However, the use of a torsional spring introduces some problems in the assembling process. As the torsional spring tends to rotate the dose-setting member back to the zero position, a mechanism preventing this must also be provided. The pen described in WO20081 16766 is based on a push spring. A non-rotating screw is axially locked by a thread engagement with a nut, which is locked against rotation when the pen is in dose setting mode. When setting a dose a dose tube, which is also engaged with the thread on the screw, is rotated, and due to the engagement with the screw the dose tube is elevated towards the push-button end, and the push spring is thereby loaded. When a user injects the set dose, the push-button is depressed and the nut is thereby set free to rotate due to the torque arising from the thread engagement with the screw. The problem with this configuration is that when an injecting is carried out the nut rotates in the same direction as when the dose was set, and therefore it is not possible to rotate a numbered display member back to its initial position in a simple mechanical way. This configuration is therefore not suited for mechanical pens comprising a numbered display member.
WO2006045529 describes a device based on a push-spring, which has a mechanical display member with helical arranged numbers, and which is capable of rotating more than one revolution. A screw is engaged with a housing via a thread. A nut, which is rotationally coupled to the numbered display member, is engaging the same thread on the screw, and between the nut and the display member a push-spring is arranged. An index feature, which indexes the dose setting at specific amounts of medicament to be injected, is rotationally locked to the screw. A locking feature is rotationally but not axially locked to the screw, and this locking feature is further more connected to a release feature, which by operation of a user can set the locking feature free to rotate. The release feature is operated perpendicular to the axis of the device and close to the needle. Rotating the numbered display member by means of a dose selector, which in turn rotates the nut and compresses the spring, sets a dose. When the release feature is operated, and the locking nut is set free to rotate, the screw, the nut, the display member and the index feature rotates as well because of the force arising from the push-spring and the non self locking thread engagement between the screw and the housing. However, the user interface is not very well suited for injections in awkward positions. WO2011060786 describes a device based on a push- spring but with a push-button in the end. A screw is engaging a housing via a thread, and a nut, which is rotationally coupled to a dose member, is engaging the thread on the screw as well. Between the nut and the dose member a push-spring is arranged. A non-axial moving one-way ratchet is rotationally coupled to the screw and ensures that the screw can only move forward. When a dose is set the nut and the dose member is rotated by mean of a dose selector, and as the nut elevates the push-spring is compressed. The dose mem- ber is indexing the dose setting via a two-ratchet, and when the push-button is pushed the dose member is set free to rotate. Due to the spring force the nut and the dose member is pushed away from each other, and due to the non self locking thread engagement between the screw and the housing this will in turn rotate the nut, the dose member, the spring and the one-way ratchet, which all are rotationally coupled to the dose member during injection. The dose member can either be provided with helically arranged numbers printed on the outside, or an external display member can be present. This configuration can also be difficult to use in awkward positions and areas of the body.
It is a first objective of the invention to provide a spring driven injection device, which is easy to use on all areas of the body.
More of the previous described devices comprise numbered display members that rotates and moves up and down at the same time, and with helically arranged numbers. WO20131 10538 describes a device with helically arranged numbers on a dose member, which rotates in one direction when a dose is set, and in the opposite direction when the set dose is injected, and which does not move axially. To be able to read the number, which corresponds to the set dose, a sliding window, which moves axially in an opening in the housing, is provided. When numbers are arranged helically, however, there are large areas in the ends of the number scale, where numbers cannot be printed, and a helically arranged number scale is therefore rather long.
It is a second objective of the invention to provide a mechanism for a spring driven device, which provides more space for numbers.
All the above described injection devices as well as devices available on the market are equipped with a removable cap. As also the needle is covered by a cap, which must be removed before use, it can be difficult for a user to handle all the loose part, especially if the injection is taken e.g. in a train or in other public places. It is a third objective of the invention to provide an injection device, which is easier to prepare for injection.
Brief description of the invention
The invention relates to a mainly cylindrical dose delivery device defining a main axis and comprising a housing,
a dose-setting member,
a first dose member with numbers printed on an external cylindrical surface following at least two circular paths,
a window, wherein a dose can be set by rotating the dose-setting member relative to the housing, and whereby the first dose member follows the rotation of the dose-setting member during the setting of the dose, and wherein the window does not rotate relative to the housing, and wherein, during rotation of the first dose member, the num- bers printed on the first dose member are visible one by one through the window, characterized by that during rotation of the first dose member the relative movement between the first dose member and the window is following a path defined by a sequence of circular and not circular movements. In this way the numbers, which are indicating the size of a set dose, can be printed on an element of the device in a more compact way and requiring less axial movement of the element relative to the window through which it is displayed. For example two full circular paths of numbers only require a relative movement corresponding to the distance between the circular paths, while displaying numbers that-follows a helical— path over two full revolutions requires an axial displacement two times the pitch of the helical path corresponding to the double distance. In another embodiment the path is defined by tracks on the first dose member, and a key on the sliding window engages the tracks one at the time. This makes it possible to let the ends of the track chain define the zero position stop and the max dose stop.
In a further embodiment the first dose member does not move axial relative to the housing when it rotates, and during rotation of the first dose member the window moves axial relative to the housing over a first angle of the first dose member, and the window does not move axial over a second angle of the first dose member de- fined by the remaining angle of a full revolution, the second angle being larger than the first angle. As the relative movement between the first dose member and the window pulses, it is an advantage to let the window slider move relative to the housing instead of the first dose member, as the window has a much lower mass. In an even further embodiment an area on the window comprises a magnifier that enlarges the numbers, which are visible through the window. It is an advantage and very easy to build in a magnifier in the window, as this does not require an extra part and as it will increase the readability of the numbers. In an even further embodiment the dose delivery device further comprises: a driver rotationally coupled to the first dose member,
a screw threadedly engaged with the housing and with the driver and cooperating with a piston in a medicament filled cartridge,
a ratchet between the screw 8 and the housing, wherein the ratchet only allows the screw to rotate in a direction, which pushes the piston into the cartridge so that medicament are expelled out through a needle, and wherein, during dose setting, the driver is rotated in the blocked direction of the screw, whereby it is moved away from the cartridge, and wherein, during injection, the first dose member is rotationally coupled to the screw. In this way the rotational movement of the screw is transferred to the first dose element, and the first dose element does not have to carry a thread engagement with any elements of the device.
In an even further embodiment the dose delivery device further comprises: a trigger sleeve arranged coaxial with the housing,
a pretensed spring for injecting a set dose,
indexing means indexing the first dose member relative to the housing at equally spaced positions around the revolution, wherein during dose setting the rotation of the driver is against the bias of the spring, and wherein rotation of the driver further tense the spring, and wherein the indexing means are strong enough to prevent the first dose member from rotating due to the spring force from the spring, and wherein axial movement of the trigger sleeve rela- tive to the housing disengage the indexing means. In this way the steep non self locking thread angle in the thread connection between the housing and the screw is utilized to rotate the screw and the first dose member during injection, because the spring force acts on both the driver and the screw as they are locked together during injection.
In an even further embodiment according to the invention a dose delivery device comprises: a housing,
a cartridge holder fixed in the housing and containing a medicament filled cartridge, a needle attached to the cartridge holder,
a cartridge cover arranged coaxially over the cartridge holder,
a needle cover arranged coaxially with and between the cartridge holder and the cartridge cover, wherein the cartridge holder and the cartridge cover has elongated openings, which at a first rotational position of the cartridge cover are unaligned, whereby the cartridge in the cartridge holder is not visible, and which at a second rotational position of the cartridge cover are aligned, whereby the cartridge in the cartridge holder is visible, characterized by when the cartridge cover is in the first rotational position the needle cover is locked in a position where the needle is inaccessible for injection, and when the cartridge cover is in the second rotational position, the needle is accessible for injection. This has the big advantage that a user does not have to handle a loose cap for the device and the convenience of taking an injection is increased.
In an even further embodiment, when the cartridge cover is in the second rotational position, the needle cover is displaced axially and locked in a position where the needle is exposed through a hole in the end of the needle cover. This embodiment exposes the needle in just one movement of the cartridge cover, and makes it easy for a user to see and follow the insertion of the needle.
In an even further embodiment, when the cartridge cover is in the second rotational position, the needle cover is unlocked and axially displaceable against the bias of a spring, whereby the needle is exposed through a hole in the needle cover. This is very advantageously for people having fear of needles, as they can inject them self, without being able to see the needle at any time.
In an even further embodiment of the invention the dose delivery device further comprises: a trigger for injecting a set dose, and, when the cartridge cover is in the first rotational position, the trigger is locked to prevent a set dose to be injected, and wherein, when the cartridge cover is in the se- cond rotational position, the trigger can be operated to inject a set dose. In this way a user can set a dose to prepare the device for injection, without having the risk of firing the device by accident during dose setting.
The objectives of the invention can be obtained by an injection device comprising a housing and a cartridge with the medicament to be injected. A linear push spring is adapted to be preloaded between a driver engaged with a screw via a thread and a first dose member, the driver and the first dose member are rotationally but not axially coupled and the first dose member has numbers printed on the outer cylindrical surface. The screw, which is also engaging the housing via the thread, has one or more longitudinally tracks and is rotationally coupled to a one-way ratchet, which is axially fixed relative to the housing, and which only allows rotation in one direction.
When a dose is set, a dose-setting member is rotated, which in turn will rotate the first dose member, the driver and the spring. This will cause the driver to elevate into the device, and the push spring to be compressed further beyond the preloaded force. The first dose member also comprises a two-way ratchet which interacts with the housing, and which allows it to be rotated in both directions and to be indexed at certain positions around the revolution corresponding to specific amounts of medica- ment to be injected. The click torque is of a size big enough to hold against the torque, which attempts to rotate the dose-setting member back to zero position and which arises from the thread engagement between the screw and the housing. A trigger sleeve is surrounding the housing and is rotationally fixed to the housing and axially fixed to the dose-setting member. When a user grips around the sleeve and pene- trates the skin with the needle by pressing the device against the body then, after the needle is fully inserted, a continued movement of the sleeve towards the body moves the sleeve relative to the housing. As the sleeve is axially coupled to the dose-setting member this also moves the dose-setting member relative to the housing and the dose-setting member is disconnected from the first dose member. Also the first dose member is moved a small distance together with the sleeve, which disconnects the two-way ratchet from the housing and sets the first dose member and the driver free to rotate. At the same time the first dose member connects rotationally to the second dose member, and therefore also the second dose member and, due to the rotational coupling, the screw will rotate, which in turn will drive the screw and the driver forward, due to the thread engagement between the screw and the housing, and the screw advances into the cartridge. The advancement of the screw will expel the medicament due to a co-operation with a piston in the medicament filled cartridge.
The numbers printed on the first dose member can be viewed through a transparent area in a window movable in an opening in the housing. The numbers are arranged in circles above each other and around the outer surface of the first dose member. The window is adapted to move axially in the opening in the housing, such that when the all numbers in one circle has been displayed one by one through the window, the window will move up in the device and allow the numbers of the next circle to be displayed and so on. The movable window is engaging a track in the first dose mem- ber, which controls the axial position of the window.
In other embodiments the numbers are printed on a scale drum and relative axial movement between the window and the scale drum can be obtained by axial movements of both the window and the scale drum, or solely by axial movement of the scale drum.
The cartridge with the medicament is contained in a cartridge holder, which is fixed to the housing. The cartridge holder has elongated windows, which allows a user to inspect the content of the cartridge. A tube formed cartridge cover also comprising two elongated windows is arranged coaxial with the cartridge holder, and the cartridge cover can either be in a rotational position where the windows of the cartridge holder and the cartridge cover are aligned, and inspection of the cartridge content is possible, or in a rotational position where the windows are not aligned, and the cartridge is fully covered by the cartridge holder and the cartridge cover. A needle cover is arranged in the end of the device. By rotation of the cartridge cover to the open position, which allows inspection, the needle cover is retracted to a position where the needle is free to be inserted. The needle cover has an opening in the end to allow the needle to be exposed, and the needle cap on the needle to be removed. The cartridge cover is indexed in one of two rotational positions by a spring, and the cartridge cover and the needle cover can be removed from the device, when it is desired e.g. if the cartridge must be replaced.
The first dose member can be arranged to provide a clicking sound against the housing when a set dose is injected. An advantage by using the first dose member is, that it always ends in the same position, and it is therefore possible to configure different sounds at certain intervals, e.g. at 0,10,20 units, by changing the height or width of the relevant teeth.
Figures
In the following the invention is described in further details with reference to the drawings, wherein
Figure 1 shows a perspective view of a pen according to the invention
Figure 2 shows an exploded view of the pen according to the invention
Figure 3 schematically shows a vertical sectional view of a pen according to the invention ready to set a dose
Figure 4 schematically shows a vertical sectional view of a pen according to the invention where a dose has been set.
Figure 5 schematically shows a vertical sectional view of a pen according to the invention where a dose has been injected and the trigger sleeve is still activated Figure 6 shows an exploded and partly sectional view of the number display mechanism Figure 7 shows a perspective view of the sliding window
Figure 8 shows a perspective view of the scale drum
Figure 9 schematically shows a vertical sectional view of a pen according to the invention where the cartridge and needle cover mechanism is visible in close position
Figure 10 shows an exploded view of the cartridge and needle cover mechanism
Figure 1 1 shows a perspective view of the cartridge and needle cover mechanism in closed position
Figure 12 shows a perspective view of the cartridge and needle cover mecha- nism in open position
Detailed description
In the following the term main axis defines the common axis of revolution for the mainly tube shaped parts and for the entire injection device. Only the parts necessary to understand the function is included in the description, however, the drawings may show other parts, which could be part of an injection device comprising the feature. The terms "up" and "down" and "upper" and "lower" and "upward" and "downward" refer to the drawings and does not necessarily correspond to a situation of use. In all embodiments the described screw is abutting a plunger in a medicine filled cartridge and downward movement of the screw moves the plunger in the cartridge and medicine is pressed out through s needle. Plunger, cartridge and needle are not shown on all drawings.
In fig. 1 a perspective view of a device according to the invention can be seen. At the upper part of the device a dose-setting member 3, by which a dose can be set by rotating the dose-setting member 3 clockwise and corrected downward by rotating the dose-setting member 3 anticlockwise, can be seen. Also a trigger sleeve 5, by which a set dose is injected, is visible. The trigger sleeve 5 is axial connected to the dose- setting member 3, and a set dose is injected by gripping around the trigger sleeve and pressing the needle end of the device with the needle inserted against the skin. In the lower end of the device the cartridge cover 12 with a window 51 and the needle cov- er 13 can be seen. The device is prepared for injection by rotating the cartridge cover 12 an angle. This will align the window 51 in the cartridge cover 12 with a corresponding window 49 in a cartridge holder 1 1 inside the cartridge cover, and the content of the cartridge contained in the cartridge holder 1 1 will be visible. Rotation of the cartridge cover 12 further more retracts the needle cover 13 into the device and the needle becomes accessible. This will be further explained.
Fig. 2 shows an exploded view of a device according to the invention with all elements of the device visible. These will be referred to during the functional descriptions, especially when the sectional views do not clearly show the described feature.
In fig. 3 the dose setting and injection mechanism of a device according to the invention, can be seen. A nut 7 comprising a threaded hole 39 is fixed to the housing 1. A screw 8 has a thread 42 along the entire length of the screw 8 and is engaging the thread 39 of the nut 7, however, the thread 42 has a top in the upper end of the screw 8 to prevent the screw 8 from rotating out of the nut 7 and to prevent the user from being able to set a dose, which is higher than the remaining content of the cartridge. This will be further explained later. As can be seen on fig. 2 the screw 8 has two flat sides, which allows it to be rotationally but not axially coupled to a one-way ratchet comprising a rotational coupling part 9 and a ratchet part 10 having two ratchet arm 45, which cooperates with teeth in the nut 7. The one-way ratchet assembly 9/10 en- sures that the screw 8 can only move towards the needle, but as the part is assembled by two items 9/10 with a second ratchet between them, the user is actually able to rotate the screw 8 back into the device against a substantial torque, when the cartridge is replaced and the device is reloaded. The one-way ratchet is axially but not rotationally fixed in the nut 7. A driver 6 is also engaged with the thread 42 on the screw 8 by a thread 37. The driver 6 is further rotational but not axial connected to a first dose member 2 by means of keys 38 on the driver 6 and grooves 30 on the first dose member 2, which can clearly be seen in fig. 2, and further the first dose member 2 is releasable rotational connected to the dose-setting member 3 by means of a re- leasable teeth connection 28/34 between the first dose member and a second dose member 4, to which the dose-setting member 3 is rotational but not axial connected, and which second dose member 4 is axial but not rotational connected to the housing 1. Inside the driver 6 and the first dose member 2 a push-spring 15 is arranged. Between the dose-setting member 3 and the second dose member 4 a pretensed push- spring 16 is arranged in such a way that it applies a force to the driver 6 in the downward direction.
The first dose member 2 is engaging the housing 1 in a two-way ratchet connection consisting of teeth 27 on the first dose member 2 cooperating with grooves 19 in the housing 1. The first dose member 2 is capable of moving a small distance down in the device against the bias of the push-spring 15, which will in turn disconnect the two-way ratchet between the first dose member 2 and the housing 1 , and set the first dose member 2 free to rotate. A recess in the housing 1 and a sliding surface on the first connecting member 2 prevents the first dose member 2 from moving up in the device due to the spring force. The first dose member 2 also comprises teeth 29, which during injection will engage the first dose member 2 with the ratchet assembly 9/10 by means of cooperating teeth 43 on the rotational coupling part 9 and thereby the first connecting part 2 is locked to the screw 8. The first dose member 2 has further more printed numbers on the outside cylindrical surface, which is visible through an opening in the housing 18 and a transparent area 60 in a movable window 22. This will be further explained later.
To avoid that a user can set a dose, which is higher than the remaining content in the cartridge, the thread 42 on the screw 8 has a stop in the upper end. When a user attempt to set a dose of an amount, which the device would not be able to inject, the stop in the thread 42 will abut the end of the thread segments 37 in the driver 6, and further dose setting is prevented.
A trigger sleeve 5 is arranged coaxial with the housing 1. The trigger sleeve 5 is rotational connected to the housing 1 via grooves in the trigger sleeve 5 engaged with keys 20 on the outside surface of the housing 1 , which in turn allows the trigger sleeve 5 to move axial a small distance relative to the housing 1. The trigger sleeve 5 is also axially but not rotationally locked to the dose-setting member 3 via a recess 36 inside the trigger sleeve 5 engaging flaps 31 on the dose-setting member 3.
When a dose is set the dose-setting member 3 is rotated clockwise. Fig. 3 shows a device according to the invention where a dose has not yet been set, and it is clear that the first dose member 2 and the ratchet assembly 9/10 are disengaged, while on the other hand the first dose member 2 is engaging the housing 1 in the two-way ratchet connection 19/27, and the second dose member 4 in the teeth connection 28/34 (see fig. 2). The driver 6 is in the zero position close to the ratchet assembly 9/10. As the dose-setting member 3 and the second dose member 4 are rotational locked, rotation of the dose-setting member 3 also rotates the first dose member 2, and due to the two-way ratchet 27 the first dose member 2 is indexed equally around the revolution relative to the housing 1 in specific positions corresponding to specific amounts of medicament. The rotational movement between the indexing positions produces a clicking sound and a tactile feed back. As the driver 6 is rotational locked to the first dose member 2 and as the screw 8 cannot rotate in the clockwise direction due to the engagement with the one-way ratchet assembly 9/10, the driver 6 will be rotated and elevated up in the device due to the thread engagement 39/42 with the screw 8, and the push-spring 15 is further tensed. Fig. 4 shows a device where a dose has been set. Now the driver 6 has moved up in the device, and away from the ratchet assembly 9/10, and as none of the first dose member 2 and the driver 6 are able to rotate relative to the nut 7 fixed in the housing 1 , there is no torque applied to the screw 8. The spring force arising from the push- spring 15 is acting on the thread connection 39/42 between the screw 8 and the nut 7, and on the thread connection 37/42 between the screw 8 and the driver 6, and the screw 8 is in balance.
In fig. 5 the set dose has been expelled. Before expelling the dose the user has rotated a cartridge cover 12, which in turn has revealed the cartridge and enabled the user to inspect the content of the medicament in the cartridge. The rotation of the cartridge cover 12 has also retracted a needle cover 13 and the needle is made accessible. This will be further explained later. To inject the dose the user holds around the trigger sleeve 5 with the thumb and the index finger, just like a person would hold an ordinary pen. The needle is fully inserted in the skin until the contact face 54 on the car- tridge cover 12 is in contact with the skin (see fig. 2). When the user hereafter continues to press the device against the skin, the trigger sleeve 5 will begin to move axial relative to the housing 1 and against the force of the push-spring 15 and because of the axial connection between the dose-setting member 3 and the trigger sleeve 5, the dose-setting member 3 moves too. As the force required to inject a set dose is ra- ther high, the force of the push-spring 15 must be rather high, and therefore a return spring 16 applying a force to the dose-setting member 3 in the opposite direction is arranged between a shelf 59 on the dose-setting member 3 and protrusions 32 on the second dose member 4. The return spring 16 is pretensed to a level, which results in a low and convenient trigger force when a user triggers the injection by pressing the device against the skin. The dose-setting member 3 is mating the first dose member 2 in a sliding surface 58 on a very little diameter, and therefore the first dose member 2 is pushed down as well. This disengages the two-way ratchet 27 from the teeth 19 in the housing 1 and the teeth 28 from the teeth 34 on the second dose member 4, and the first dose mem- ber 2 is set free to rotate. As the axial movement of the first dose member 2 also causes the part to connect rotational with the ratchet assembly 9/10, a range of parts are now rotationally locked together, which is the first dose member 2, the driver 6, the ratchet assembly 9/10, the push-spring 15 and the screw 8, and all the mentioned parts rotates between the sliding surface 58 on the dose-setting member 3 in one end, and a sliding surface between the screw 8 and a foot 14, which abuts the piston in the cartridge (not shown), in the other end. Because the push-spring 15 pushes the driver 6 toward the needle end, the whole packet of parts will rotate due to the thread engagement 39/42 between the screw 8 and the nut 7. There is no load on the rotational movement of the parts, and the parts can easily rotate transmitting the force from the push-spring 15 to the foot 14 with a very high efficiency, and pressing the medicament out of the needle. The rotation of the ratchet assembly 9/10 causes the ratchet arm 45 on the ratchet part 10 to click in the rotational arranged teeth in the nut 7.
As it is understood from the previous descriptions, the first dose member 2 rotates clockwise when a dose is set to be higher, and anticlockwise when a dose is reset to be lower or when a set dose is injected, and therefore numbers can be printed on the first dose member 2 to display the size of a set or remaining dose through an opening 18 in the housing 1. When looking at fig. 6 the first dose member 2 does not move axially relative to the housing 1 except from the limited triggering displacement, and therefore the numbers cannot be printed on a helical track and shown one after another in a fixed window in the housing 1. Instead the numbers are printed in circles on the first dose member 2, and a movable window 22 with a transparent area 60 is capable of sliding up and down in the opening 18 in the housing 1 , and is displaying numbers on one row after another, such that during dose setting, when all numbers in one circle have been shown, the window 22 moves axially to the next circle and displays the numbers in the circle one by one during the continued dose setting. As seen on fig. 7 the sliding window 22 has a protrusion 57, which engage a combination of circular tracks 25 and slanted tracks 26 on the first dose member 2. The angle of the slanted tracks 26 forms a not axially self-locking connection with the protrusion 57 on the movable window 22, such that when the protrusion 57 is in the slanted track 26, then relative rotation between the parts will cause the window 22 to move axially relative to the first dose member 2, and such that this axial movement will cause the window 22 to shift to the next circular track 25.
In other embodiments the numbers are printed on a scale drum 67 (see fig. 8) and relative axial movement between the window 22 and the scale drum 67 can be obtained by axial movements of both the window 22 and the scale drum 67, or solely by axial movement of the scale drum 67. The scale drum 67 is rotationally connected to the first dose member 2 by ribs 68 engaging longitudinally track on the first dose member 2, and the circular and slanted tracks 69/70 on the scale drum 67 is engaging an inwardly protruding element on the window 22 or inside the housing 1. In the case of a non moving window 22, the circular and slanted tracks 69/70 can also be in the housing 1 , or they can be partly in the housing 1 and on the scale drum 67.
In the following the covering and uncovering of the cartridge and needle will be ex- plained with reference to fig. 9-12. Due to the risk of injuries it is obvious that the needle must be covered until the injection is actually taken place, but as most injectable medicaments are sensitive to light, and also to avoid breaking the cartridge during the handling of the device, the cartridge too must be covered. In fig. 9 a full sectional view of a device according to the invention can be seen where the cover mech- anism is in its closed position. The cartridge holder 1 1 that contains the cartridge (not shown) is fixed in the housing 1 by means of a thread connection between the parts. Coaxial with the cartridge holder 1 1 a cartridge cover 12 is arranged and a needle cover 13 is connected with the cartridge cover 12 in such a way, that by rotation of the cartridge cover relative to the cartridge holder 1 1 the needle cover 13 retracts up in the cartridge cover 13 to be fully covered. The needle cover 13 is rotationally locked to the cartridge cover 12 by means of keys 53 on the cartridge cover 12 and slots 55 on the needle cover 13. An index spring 17 is provided between the cartridge holder 1 1 and the cartridge cover 12 to help indexing the cartridge cover 12 in an open and a closed position. As shown in fig. 10 the cartridge holder 1 1 has a track 47, which cooperates with protrusions 50 in the cartridge cover 12. The index spring 17 pushes the cartridge cover 12 towards the needle end and indexes the cartridge cover 12 in two rotational positions by pushing the key 50 in the cartridge cover 12 down in the groove 64 in the track 47 to set the cartridge cover 12 in the closed position, and down in the groove 63 to set the cartridge cover 12 in the open position. The cartridge holder 1 1 has two windows 49, which extends along the axis of the part and opposite each other and each covering an angle of less than 90°, and the cartridge cover 12 has two corresponding windows 51. In the closed position the two sets of windows 49/51 are rotated 90° relative to each other, and in the open position, the windows are aligned and a user can inspect the content of the cartridge. The track 47 on the cartridge holder 1 1 has an outlet 62, which allows a user to take off the.cartridge cover 12, e.g. to attach a new needle. The grooves 63/64 has rounded edges such that the protrusion 50 in the cartridge cover 12 will jump up and down of the grooves just by rotation of the cartridge cover 12, while a user must press the cartridge holder 12 up and rotate to disengage the cartridge cover 12 from the cartridge holder 1 1 via the outlet 62. Due to the closed track 55 on the needle cover 13 the needle cover 13 cannot disengage from the cartridge cover 12, and the needle cover 13 will follow the cartridge cover 12, when it is mounted or disengaged from the cartridge holder 1 1. Due to the key 53 in the cartridge cover 12 operating in the closed grooves 55 on the needle cover 13, the needle cover 13 can move axially in relation to the cartridge cover 12, but it cannot rotate. The needle cover 13 has two protrusions 56 on the inner cylindrical surface which are engaging a helical track 48 on the cartridge holder 1 1, and consequently, when the cartridge cover 12 is rotated, the needle cover 13 will move up and down in the cartridge cover 12. In the end of the track 48, near the needle end, an arc formed area 65 is provided over an angle. In the closed position of the cartridge cover 12 the protrusions 56 are positioned in the arc formed area 65 and the needle cover 13 is locked against axial movement. In another embodiment (not shown) the needle cover 13 does not move axially when the cartridge cover 12 is rotated, but instead rotation of the cartridge cover 12 unlocks and locks the needle cover 13, such that when the cartridge cover is in the open position, it is possible to press the needle cover up in the cartridge cover against the bias of a spring.
Fig. 1 1 shows the cartridge cover in the closed position, and it is clearly seen that the cartridge holder 1 1 is covering the windows 49 in the cartridge cover 12 and the cartridge contained in the cartridge holder 1 1 is hidden. It is also seen that the needle cover 13 totally covers the needle and makes it inaccessible. In fig. 12 the cartridge cover 12 has been rotated and indexed in the open position, and the windows 49 in the cartridge holder 1 1 are now aligned with the windows 51 in the cartridge cover 12, whereby it is possible to see and inspect the content of the cartridge (not shown). The needle cover 13 has a hole in the closed end to allow the needle to be exposed, when the cartridge cover 12 is in its open position.
To prevent unintended expelling of medicament during dose setting and handling of the device, the cartridge cover 12 further more comprises two protrusions 66. When the cartridge cover 12 is in its locked position, these protrusions prevent the trigger sleeve 5 from being pressed down and a set dose to be injected. When the cartridge cover 12 on the other hand is in its open position, the cut 61 in the trigger sleeve 5 can move over the protrusions 66, and the set dose can be injected.

Claims

Claims
1. A mainly cylindrical dose delivery device defining a main axis and comprising a housing 1 ,
a dose-setting member 3,
a first dose member 2 with numbers printed on an external cylindrical face following at least two circular paths,
a window 22, wherein a dose can be set by rotating the dose-setting member 3 relative to the housing 1 , and whereby the first dose member 2 follows the rotation of the dose- setting member 3 during the setting of the dose, and wherein the window 22 does not rotate relative to the housing 1 , and wherein, during rotation of the first dose member 2, the numbers printed first dose member 2 are visible one by one through the window 22, c h a r a c t e r i s e d b y during rotation of the first dose member 2 the relative movement between the first dose member 2 and the window 22 is following a path defined by a sequence of circular and not circular movements. 2. A dose delivery device according to claim 1 wherein the path is defined by
tracks on the first dose member 2, and wherein a key 57 on the window 22 is engaging the tracks of the first dose member 2 one at the time.
A dose delivery device according to claim 1 wherein, during rotation, the first dose member 2 does not move axially relative to the housing 1, and wherein, during rotation of the first dose member 2, the window 22 moves axially in an opening in the housing 1 over a first rotational angle of the first dose member 2, and wherein the window 22 does not move axial over a second rotational angle of the first dose member 2, the second rotational angle being defined by the remaining angle of a full revolution and the second angle being larger than the first angle.
A dose delivery device according to claim 1 wherein an area 60 on the window 22 comprises a magnifier, and wherein the numbers, which are visible through the sliding window 22, are enlarged by the magnifier.
A dose delivery device according to claim 1 further comprising: a driver 6 rotationally coupled to the first dose member 2,
a screw 8 threadedly engaged with the housing 1 and with the driver 6 and cooperating with a piston in a medicament filled cartridge,
a ratchet 9/10 between the screw 8 and the housing 1 , wherein the ratchet 9/10 only allows the screw 8 to rotate in a direction, which pushes the piston into the cartridge so that medicament are expelled out through a needle, and wherein, during dose setting, the driver 6 is rotated in the blocked direction of the screw 8, whereby it is moved towards the dose-setting member, and wherein, during injection, the first dose member 2 is rotationally coupled to the screw 8.
A dose delivery device according to claim 5 further comprising: a trigger sleeve 5 arranged coaxial with the housing 1 ,
a pretensed spring 15 for injecting a set dose, indexing means 19/27 for indexing the first dose member 2 relative to the housing 1 at equally spaced positions around the revolution,
wherein during dose setting the rotation of the driver 6 is against the bias of the spring 15, and wherein rotation of the driver 6 further tense the spring 15, and wherein the indexing means 19/27 are strong enough to prevent the first dose member 2 from rotating due to the spring force from the spring 15, and wherein axial movement of the trigger sleeve 5 relative to the housing 1 disengage the indexing means 19/27.
A mainly cylindrical dose delivery device defining a main axis and comprising a housing 1 ,
a cartridge holder 1 1 fixed in the housing 1 and containing a medicament filled cartridge,
a needle attached to the cartridge holder 1 1 ,
a cartridge cover 12 arranged coaxially over the cartridge holder 1 1 , a needle cover 13 arranged coaxially with and between the cartridge holder 1 1 and the cartridge cover 12, wherein the cartridge holder 1 1 and the cartridge cover 12 has elongated open- ings 49/51, which at a first rotational position of the cartridge cover 12 are unaligned, whereby the cartridge in the cartridge holder 1 1 is not visible, and which at a second rotational position of the cartridge cover 12 are aligned, whereby the cartridge in the cartridge holder 1 1 is visible, c h a r a c t e r i s e d b y when the cartridge cover 12 is in the first rotational position the needle cover 13 is locked in a position where the needle is inaccessible for injection, and when the cartridge cover 12 is in the second rotational position, the needle is accessible for injection.
8. A dose delivery device according to claim 7 wherein, when the cartridge cover 12 is in the second rotational position, the needle cover 13 is displaced axially and locked in a position where the needle is exposed through a hole in the end of the needle cover 13.
9. A dose delivery device according to claim 7 wherein, when the cartridge cover 12 is in the second rotational position, the needle cover 13 is unlocked and axially displaceable against the bias of a spring, whereby the needle is exposed through a hole in the needle cover 13.
10. A dose delivery device according to claim 7 further comprising a trigger 5 for injecting a set dose, and wherein, when the cartridge cover 12 is in the first rotational position, the trigger 5 is locked to prevent a set dose to be injected, and wherein, when the cartridge cover 12 is in the second rotational position, the trigger 5 can be operated to inject a set dose.
PCT/DK2014/000056 2013-12-18 2014-11-20 Dose delivery device with improved handling WO2015090320A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201300704 2013-12-18
DKPA201300704 2013-12-18

Publications (2)

Publication Number Publication Date
WO2015090320A2 true WO2015090320A2 (en) 2015-06-25
WO2015090320A3 WO2015090320A3 (en) 2015-09-03

Family

ID=52344905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2014/000056 WO2015090320A2 (en) 2013-12-18 2014-11-20 Dose delivery device with improved handling

Country Status (1)

Country Link
WO (1) WO2015090320A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017144601A1 (en) * 2016-02-25 2017-08-31 Novo Nordisk A/S A medical injection device with a axially movable shield
CN108495678A (en) * 2015-11-27 2018-09-04 赛诺菲-安万特德国有限公司 Injection device
US10850036B2 (en) 2015-08-27 2020-12-01 E3D Agricultural Cooperative Association Reusable automatic injection device
WO2022117684A1 (en) * 2020-12-02 2022-06-09 Sanofi Drive subassembly for a drug delivery device, arrangement, method for assembling a drug delivery device, container-holder subassembly for a drug delivery device, kit and drug delivery device
US11504475B2 (en) 2010-06-28 2022-11-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
AU2019296449B2 (en) * 2018-06-29 2023-01-12 Anthony Scott HORSTMAN Rotary locking safe insulin injection needle
WO2023209130A1 (en) * 2022-04-27 2023-11-02 Medmix Switzerland Ag Cartridge holding unit
US11865306B2 (en) 2014-02-10 2024-01-09 E3D A.C.A.L Ltd Semi disposable auto injector

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045528A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with torsion spring and rotatable display
WO2006045529A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with internal dose indicator
WO2008116766A1 (en) 2007-03-23 2008-10-02 Novo Nordisk A/S An injection device comprising a locking nut
WO2011060786A1 (en) 2009-11-20 2011-05-26 Moeller Claus Schmidt Spring actuated dose delivery device
WO2013110538A1 (en) 2012-01-27 2013-08-01 Novo Nordisk A/S Injection device with a sliding scale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5921966A (en) * 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
DE102007026560A1 (en) * 2007-06-08 2009-01-15 Tecpharma Licensing Ag Delivery device with axially movable indicator
WO2011060785A1 (en) * 2009-11-20 2011-05-26 Moeller Claus Schmidt Injection device without a gearing
CN103974732B (en) * 2011-12-14 2016-08-24 诺沃—诺迪斯克有限公司 There is the injection pen of the mechanical dose display part including big digital code

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045528A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with torsion spring and rotatable display
WO2006045529A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with internal dose indicator
WO2008116766A1 (en) 2007-03-23 2008-10-02 Novo Nordisk A/S An injection device comprising a locking nut
WO2011060786A1 (en) 2009-11-20 2011-05-26 Moeller Claus Schmidt Spring actuated dose delivery device
WO2013110538A1 (en) 2012-01-27 2013-08-01 Novo Nordisk A/S Injection device with a sliding scale

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504475B2 (en) 2010-06-28 2022-11-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11813436B2 (en) 2010-06-28 2023-11-14 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11865306B2 (en) 2014-02-10 2024-01-09 E3D A.C.A.L Ltd Semi disposable auto injector
US11786658B2 (en) 2015-08-27 2023-10-17 E3D A.C.A.L. Ltd Reusable automatic injection device
US10850036B2 (en) 2015-08-27 2020-12-01 E3D Agricultural Cooperative Association Reusable automatic injection device
US11439770B2 (en) 2015-11-27 2022-09-13 Sanofi-Aventis Deutschland Gmbh Injection device
CN108495678A (en) * 2015-11-27 2018-09-04 赛诺菲-安万特德国有限公司 Injection device
WO2017144601A1 (en) * 2016-02-25 2017-08-31 Novo Nordisk A/S A medical injection device with a axially movable shield
JP2019509799A (en) * 2016-02-25 2019-04-11 ノボ・ノルデイスク・エー／エス Medical injection device having a shield movable in the axial direction
CN108697842A (en) * 2016-02-25 2018-10-23 诺和诺德股份有限公司 Medication injections device with axial movable shield
AU2019296449B2 (en) * 2018-06-29 2023-01-12 Anthony Scott HORSTMAN Rotary locking safe insulin injection needle
WO2022117684A1 (en) * 2020-12-02 2022-06-09 Sanofi Drive subassembly for a drug delivery device, arrangement, method for assembling a drug delivery device, container-holder subassembly for a drug delivery device, kit and drug delivery device
WO2023209130A1 (en) * 2022-04-27 2023-11-02 Medmix Switzerland Ag Cartridge holding unit

Also Published As

Publication number Publication date
WO2015090320A3 (en) 2015-09-03

Similar Documents

Publication Publication Date Title
WO2015090320A2 (en) Dose delivery device with improved handling
RU2401133C2 (en) Automatic injection device with upper unlock mechanism
US9956351B2 (en) Injection device without a gearing
EP2618872B1 (en) A gearing mechanism for a dose delivery device
CA2500195C (en) Injecting device
US8083711B2 (en) Injection device with internal dose indicator
JP5230722B2 (en) Injection device with lock nut
JP4350525B2 (en) Drug dispensing device with gear set giving mechanical advantages
JP4954091B2 (en) Dose setting element for an injection device having a dose setting limiting mechanism
JP6371834B2 (en) Forward-loading drug delivery device with moved cartridge holder and piston rod coupler
EP3164172B1 (en) Spring arrangement and drug delivery device herewith
JP6316945B2 (en) Drug delivery device having piston rod coupler
CA3111681C (en) Injection device
EP3768359A1 (en) Drive mechanism for an injection device

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14825259

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14825259

Country of ref document: EP

Kind code of ref document: A2