WO2015084693A3 - Nouveau procédé de préparation de loratadine à partir d'un intermédiaire de cétone - Google Patents
Nouveau procédé de préparation de loratadine à partir d'un intermédiaire de cétone Download PDFInfo
- Publication number
- WO2015084693A3 WO2015084693A3 PCT/US2014/067846 US2014067846W WO2015084693A3 WO 2015084693 A3 WO2015084693 A3 WO 2015084693A3 US 2014067846 W US2014067846 W US 2014067846W WO 2015084693 A3 WO2015084693 A3 WO 2015084693A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- loratadine
- ketone intermediate
- new process
- active carbon
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention se rapporte à un procédé de synthèse de dernière étape destiné à fabriquer de la loratadine à partir d'un intermédiaires de cétone.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361912133P | 2013-12-05 | 2013-12-05 | |
US61/912,133 | 2013-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015084693A2 WO2015084693A2 (fr) | 2015-06-11 |
WO2015084693A3 true WO2015084693A3 (fr) | 2015-10-22 |
Family
ID=53274263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/067846 WO2015084693A2 (fr) | 2013-12-05 | 2014-12-01 | Nouveau procédé de préparation de loratadine à partir d'un intermédiaire de cétone |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015084693A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016206028A1 (fr) * | 2015-06-24 | 2016-12-29 | 苏州大学张家港工业技术研究院 | Procédé de préparation de phosphate de cyclopropyle |
CN106478595B (zh) * | 2016-09-18 | 2019-05-21 | 西安交通大学 | 氯雷他定晶型及其制备方法和用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271378B1 (en) * | 1998-12-18 | 2001-08-07 | Schering Corporation | Process for preparing tricyclic compounds having antihistaminic activity |
US20080194823A1 (en) * | 2006-04-04 | 2008-08-14 | Mayur Devjibhai Khunt | Preparation of loratadine form i |
US7449583B2 (en) * | 2001-11-05 | 2008-11-11 | Zach System S.P.A. | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) |
CN102336739A (zh) * | 2011-07-15 | 2012-02-01 | 海南灵康制药有限公司 | 一种氯雷他定化合物及其制法 |
-
2014
- 2014-12-01 WO PCT/US2014/067846 patent/WO2015084693A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271378B1 (en) * | 1998-12-18 | 2001-08-07 | Schering Corporation | Process for preparing tricyclic compounds having antihistaminic activity |
US7449583B2 (en) * | 2001-11-05 | 2008-11-11 | Zach System S.P.A. | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) |
US20080194823A1 (en) * | 2006-04-04 | 2008-08-14 | Mayur Devjibhai Khunt | Preparation of loratadine form i |
CN102336739A (zh) * | 2011-07-15 | 2012-02-01 | 海南灵康制药有限公司 | 一种氯雷他定化合物及其制法 |
Also Published As
Publication number | Publication date |
---|---|
WO2015084693A2 (fr) | 2015-06-11 |
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