WO2015066781A1

WO2015066781A1 - Phototherapy apparatus and use of radiation apparatus with aiming of light beam and/or target

Info

Publication number: WO2015066781A1
Application number: PCT/BR2014/000049
Authority: WO
Inventors: Rodrigo Fernando Bianchi; Eduardo Quaresma GONÇALVES
Original assignee: Universidade Federal De Ouro Preto - Ufop
Priority date: 2013-11-05
Filing date: 2014-02-13
Publication date: 2015-05-14
Also published as: BR102013028476A2

Abstract

The present invention relates to an apparatus for aiming light beams at jaundiced newborns being treated with neonatal phototherapy, comprising one or more light sources, including in the absorption range for bilirubin and its isomers (spectral range from 300-800 nm), and with another colour or spectrum, allowing jaundiced patients to be ideally positioned under phototherapeutic sources, in that the optionally intermittent light beam and/or target is aimed for use on jaundiced newborns in incubators, maternities, hospitals, pediatric units, intensive care units and homes. The apparatus has various uses for medical, hospital, commercial and aesthetic treatments with ionizing radiation or non-ionizing radiation, for therapeutic or technical purposes, such as artificial tanning, treatment of vitiligo, oncological treatment, disinfestation, inhibiting plant sprouting and delaying the ripening of foodstuffs.

Description

PHOTO THERAPY AND USE OF LIGHT BEAM AND / OR TARGET RADIATION

FIELD OF INVENTION

The present invention is a device for target beam and / or light targeting to jaundiced newborns under neonatal phototherapy, composed of one or more light sources, one selected within the absorption band of bilirubin and its isomers. (spectral range 300 to 800 nm), and any of any color or spectrum that enables optimal positioning of jaundiced patients under phototherapy sources, by means of flashing beam and / or flash targeting for use in jaundiced newborns in incubators, maternity wards, hospitals, pediatric units, intensive care units and households. The device has a variety of uses in medical, hospital, commercial and aesthetic treatments, with ionizing or non-ionizing radiation and for therapeutic or technological purposes, such as artificial tanning, vitiligo treatment, cancer treatment and disinfestation, budding inhibition and maturation delay. of food.

BACKGROUND OF THE INVENTION AND ART STATE

Neonatal jaundice results from the predisposition to bilirubin production by the newborn (NB) and its ability to excrete it vide (DL Wong, Pediatric Nursing, 5th ed. Rio de Janeiro, Ed. Guanabara (1999); TWR Hansen, Therapeutic Approaches to Neonatal Jaundice: An International Survey, Clinical Pediatrics 35, 6, 309-16 (1996); L. Grossweiner, The Science of Phototherapy: an Introduction, Ed. Jones & Linda R. (2005); PK Vandiborg, Dose- response relationship of phototherapy for hyperbilirubinemia, Pediatrics 130, 352-357 (2012); MJ Maisels, Neonatal jaundice, Pediatrics Review 27, 443-454 (2006); S. Simmons, This just in: hyperbilirubinemia in neonates: prevention, early identification, and treatment, Advances in neonatal care 11, 5, s22-s27 (2011) MJ Maisels, AF Mcdonagh, Phototherapy for Neonatal Jaundice The New England Journal of Medicine 358, 9, 920-928 (2008); Maisells, Neonatal hyperbilirubinaemia and kernicterus - not gone but sometimes forgotten, Early H Development 85, 11, 727-732 (2009); ALC Ferreira, RM Nascimento, RCSS Veríssimo, Irradiation of phototherapy devices in maternity hospitals in Maceió, American Journal of Nursing 17, 5 (2009); R. Klielmann, P. Nohama, Evaluation of phototherapy equipment in the treatment of neonatal hyperbilirubinemia in Curitiba Maternities, II Latin American Congress of Ingeniería Biomédica; 23 to 25 May 2001. La Habana, Cuba; JV de Oliveira, Technical Evaluation of the phototherapy devices of the neonatology service of the South Wing Regional Hospital, Monografia (Pediatric Residence), Asa Sul Regional Hospital / SES / DF, (2006). About sixty percent of newborns are estimated to have serum bilirubin levels greater than 5 mg / dl, and their etiology is typically multifactorial. Fortunately, simple blue light phototherapy (400-500 nm, peak at 460 nm) is the most commonly used therapeutic procedure in the treatment of this condition and aims, above all, for the rapid reduction of serum bilirubin levels of newborns. In Brazil, according to DAT ASUS, in 2011 (Department of Informatics of SUS - DATASUS Ministry of Health. Available at: http://www2.datasus.gov.br/datasus/index.php?acao=l l & id = 30730. Accessed in June 2013) of the Ministry of Health, 1,839,220 Brazilian newborns have jaundice in their first days of life, with 293,371 newborns exposed to phototherapeutic treatments. Of these, 8% in the Midwest, 11 1% in the North, 13% in the South, 29% in the Northeast and 39% in the Southeast.

Also according to DATASUS 201 1, neonatal mortality associated with neonatal hyperbilirubinemia and its complications is 0.1%, but may reach, according to world statistics see (Design Revolution Available at: http://www.d-rev.org. Access in June 2013), up to 10% in less developed regions. Associated with these figures, also according to the medical literature, see (JA Owa, OJ Adebami, FF Fadero, TM Slusher, Irradiance Readings of Phototherapy Equipment: Nigeria, The Indian Journal of Pediatrics 8, 996-998 (2011); RK Pejaver, J. Vishwanath, An Auditor of Phototherapy Units, The Indian Journal of Pediatrics 67, 12, 883-884 (2000); M. de Carvalho, J. Lopes, A. Maria, Phototherapy at Rio de Janeiro Public Hospitals: Not Everything illuminating treats, Journal of Pediatrics 67, 157-162 (1991); American Academy of Pediatrics, Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, Pediatrics 94, 4, 1 192-1 199 (2009); Investigators of the National Perinatal Neonatal Database -NNPD, Morbidity and Mortality among Outborn Neonates at 10 Tertiary Care Institutions in India During the Year 2000, Journal of Tropical Pediatrics 50, 3, 170-174 (2004); TM Slusher, A. Zipursky; VKA Bhutani, A Global Need for Affordable Neonatal Jaundice Technologies, Seminars in Perinatology 35, 185-191 (2011); Jaundice is a critical global health issue among newborns, at http://d-rev.org/projects/brilliance/nind.html; K.L. Tan, The Nature of the Dose Response Relationship of Neonatal Phototherapy for Hyperbilirubinaemia, The Journal of Pediatrics 90, 3,444,452 (1977); M. de Carvalho, Treatment of Neonatal Jaundice, Jornal de Pediatria 77, 71-80 (2001); T.M. Lee, C.C.H. Chan, Dose-response relationship of phototherapy for seasonal affective disorder: meta-analysis, Acta Psychiatrica Scandinavica 99, 5, 315-323 (1999)), the light intensity (irradiance) that affects the newborn is one of the main factors influencing the quality of phototherapeutic treatment with blue light. Inefficiency or lack of phototherapeutic treatment results in a progressive increase in serum bilirubin levels in the newborn, which in turn can lead to sequelae such as secondary autism, deafness, blindness, brain damage and, most severe, kernicterus and death. , see (MJ Maisells, Neonatal hyperbilirubinaemia and kernicterus - not gone but sometimes forgotten, Early Human Development 85, 11, 727-732 (2009)).

In other words, the newborns' poor positioning in relation to the blue light sources makes the phototherapy treatment less effective to control jaundice, increasing, for example, the chances of sequelae resulting from this pathology. Coupled with this finding about the misplacement of newborns, it is noteworthy that small variations in the positioning of the newborn in relation to the focus of phototherapy sources can result in losses of more than 20% of irradiance in the newborn. Consequently, it increases morbidity and mortality in neonates and in some countries, such as India, see (Investigators of the National Perinatal Neonatal Database - NNPD, Morbidity and Mortality among Outborn Neonates at 10 Tertiary Care Institutions in India During the Year 2000, Journal of Tropical Pediatrics 50, 3, 170-174 (2004)), the sequelae resulting from neonatal hyperbilirubinemia represent up to 30% of cases of infant morbidity.

Due to the harm caused by the poor positioning of the NB in front of the blue light sources, the need for the development of easy-to-handle phototherapy devices accessible to low-income hospitals is justified, whose operating principle and utility favor the proper positioning of the device. Jaundiced RN against lighting from phototherapy sources, with the aim of minimizing adverse events, promoting better illumination conditions of the NB and positive interventions, and ultimately helping to assist healthcare professionals in decision-making in home environments, incubators, maternity hospitals, hospitals, pediatric units and intensive care units.

Patents US8202307B2, PI8400812-1, DEI 12004001731T5, US20070027510, Wo2005025671Al, US5698866, US6290713, US6596019, US6596016, WO2004032714A2, WO2004033028A2 and WO2004033029 All-round targeting equipment for targeting treatment of light beams to the jaundiced newborn under phototherapeutic treatment is not mentioned in the state of the art.

US2006 / 0100675 Al, WO 2006/052953 Al, US 2010/0106228 Al, GB 2476616 A, CA 2741124 Al, CA 2586847 Al and AU 2005304736 Al deal with phototherapy equipment described by flexible device consisting of blue LEDs, however The use of a focus or light target to direct light beams to the jaundiced newborn under phototherapy treatment is not mentioned in the state of the art.

PI 0007324-5, PI 0204158-8, PI 0305577-9 and MU 8701235-9, and Brazilian patent application 018110047225 of 12/05/2011 deal with LED-based devices for respectively cancer treatment, jaundice, psoriasis, HPV, and onychomycosis, however the use of a focus or light target to direct light beams to patients undergoing LED treatment is not mentioned in the state of the art. SUMMARY OF THE INVENTION

Broadly the phototherapy apparatus according to the invention comprises an optical device for exposing the jaundiced patient to suitable blue lighting conditions for treating jaundiced newborns by:

(a) a light emission spectrum light source or similar device (s) selected within the absorption band of bilirubin and its isomers (spectral range 300 to 800 nm), including light sources in the regions of violet, blue, green, yellow, orange and / or red, whether or not fitted with filter (s) and optical component (s), laser (s), LED (s), lens (s) ), mirror (s) and electrical (s) and / or magnetic component (s);

(b) a light-emitting beam and / or light source with a light emission spectrum or similar device (s) selected within the range of the visible spectrum including violet, blue, green, yellow, orange and / or red, whether or not fitted with an optical filter (s) and component (s), laser (s), LED (s), lens (s), mirror (s) and component (s) (s) and / or magnetic (s) capable of projecting or directing a beam or light target directly at or around the jaundiced newborn's body, which favors the proper positioning of the jaundiced newborn in the light of the sources phototherapy, by identifying the higher irradiance of the light source or the ideal lighting conditions of the NB.

The present invention may be used in conjunction with radiation dose indicating sensors, see patents PI0600986-7 and 0220700175455, for real time control and monitoring of radiation dose administered to jaundiced infants under phototherapeutic treatment.

The invention further provides a phototherapy apparatus described by lighting systems (incandescent, dichroic, fluorescent and halogen lasers and lamps; organic, inorganic or hybrid LED type, or combinations of two or more lamps different combinations in any configuration, arranged in light beam and / or target phototherapy devices, to direct the focus of illumination and maximum light intensity (radiance) from the phototherapy source to the body of the jaundiced newborn or any region in your surroundings.

Furthermore, the invention provides a blue light phototherapy apparatus comprising lighting systems based on flexible or rigid organic, inorganic or hybrid light-emitting devices capable of enclosing all or part of the body of the jaundiced patient;

The invention further provides a light-beam and / or light-targeting apparatus for enhancing light intensity (irradiance) in infants undergoing phototherapeutic treatment of jaundice or neonatal hyperbilirubinemia;

The invention provides a luminous beam and / or target targeting apparatus in the form of luminous films which is alternatively printed via silk screen, gravure printing, inkjet printing, or the like on a garment, diaper, pants etc;

The invention further provides a beam targeting and / or light targeting phototherapy apparatus operating on batteries, dc, direct current (dc) and / or ac (ac) sources;

The invention provides a light beam and / or light targeting apparatus in the form of luminous film and clothing in a variety of shapes, including blankets, pajamas, blouses, overalls, pants and diapers for wrapping or dressing the newborn. - born the source of phototherapy;

The invention also provides a beam or targeting apparatus for artificial tanning machines;

The invention further provides an apparatus for directing beam and / or light targets to light sources used in the treatment of vitiligo;

The invention further provides a beam and / or light targeting apparatus for photodynamic therapy sources used in the treatment of cancer patients;

The invention further provides an apparatus for directing beam and / or light targets to UV radiation sources used in germicidal and bactericidal control;

The invention further provides an apparatus for directing beam and / or light targets to ionizing radiation sources used in therapeutic and aesthetic irradiation processes;

The invention further provides an apparatus for beam targeting and / or light targeting for ionizing radiation sources used in sanitary, phytosanitary, sprout inhibiting and maturation delay food irradiation processes;

The invention further provides an apparatus for directing beam and / or light targets to ionizing radiation sources used in flower irradiation processes for sanitary, phytosanitary, commercial and technological purposes;

The invention further provides a beam-directed and / or light-targeting apparatus for inspecting and / or evaluating lighting conditions in phototherapeutic treatment of jaundice, vitiligo, skin cancer and other dermatological diseases; The invention further provides an apparatus capable of assisting treatment by skilled healthcare professionals or non-healthcare professionals and the lay public by intensifying radiance from radiation sources in patients undergoing radiation treatment, ionizing or otherwise, in hospitals, maternity hospitals , intensive care units and households;

The invention further provides an apparatus for scientific and technological study, whether systematic or not, of the effects of irradiance on patients undergoing radiation treatment, ionizing or not, in hospitals, maternity hospitals, intensive care units and households;

The invention further provides a beam-targeting and / or light-targeting apparatus for scientific and technological study, whether systematic or not, of the effects of intensity of radiation sources to evaluate the conditions of radiation processes for sanitary, phytosanitary and / or technological purposes.

The invention further provides a phototherapy apparatus with motor (s) and / or electronic device (s) and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or newborn pattern recognition system (s) and / or newborn motion detection system (s) against light source for beam direction and / or luminous targets on or around the body of jaundiced patients in real time or not;

The invention further provides a phototherapy apparatus with motor (s) and / or electronic device (s) and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or pattern recognition system (s) of patients with vitiligo and / or motion detection system (s) of these patients against the light source for beam direction and / or luminous targets on or around the body of patients with vitiligo, in real time or not;

The invention further provides a phototherapy apparatus with motor (s) and / or electronic device (s) and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or pattern recognition system (s) of patients with skin cancer, or other neoplasia, and / or motion detection system (s) of these patients against the source of light to direct beam and / or light target to the body of cancer patients, or their surroundings, in real time or not;

Attached, Figure 1 illustrates the principle of operation of the light beam targeting phototherapy apparatus for the jaundiced patient (Figure 1a). In this device, a red light target is directed to the center of the newborn (Figure 1b) for subsequent or concomitant optimal exposure of the newborn to conditions of blue light exposure (Figure 1c).

Figure 2 schematically illustrates the configuration of the electronic device of the invention.

The electronic device (100) according to the invention capable of directing a light beam and / or target to jaundiced newborns under neonatal phototherapy comprises a light source (1) within the visible range for beam or target targeting. luminous in or around the jaundiced newborns, and a light source (2) selected within the absorption band of bilirubin and its isomers (spectral range 300 to 800 nm), and another of any color or spectrum. THE Source (1) is usually an LED with emission in the visible range (violet, blue, green, orange, red etc).

Annex 1 presents photos of a phototherapy apparatus of the invention with beam and light targeting to the jaundiced patient. In this device, the red light beam is directed to the center of the NB (Annex 1) for later optimal exposure of the NB to the blue lighting conditions of neonatal phototherapy (Annex 1).

Annex 2 presents a photo of a red light target from the red light beam directed at the jaundiced patient.

Picture Listing

Figure 1: Principle of operation of the phototherapy device with beam and light targeting to the jaundiced patient. In (a) there is the RN; in (b) there is a focus-type red light source to position the RN in the best lighting conditions and finally (c) the optimal exposure of RN illumination.

Figure 2: Electronic schematic of the light beam targeting phototherapy device to the jaundiced patient.

Attachment listing

Annex 1: Applicability of the beam-and / or light-targeting phototherapy device. On the left is the red, target-type light beam and target aimed at the newborn's chest. On the right is the maximized blue light in the chest region of the newborn. The system is considered inductive because it allows health professionals to correctly direct the source of phototherapy to the region that has the greatest influence on the treatment of neonatal hyperbilirubinemia.

Annex 2: Details of the light target from the phototherapy device of this invention.

Claims

Phototherapy apparatus, characterized in that it comprises an optical device by means of: (a) a light source with a light emission spectrum or similar device (s) selected within the bilirubin absorption band and its isomers (spectral range 300 to 800 nm), including light sources in the regions of violet, blue, green, yellow, orange and / or red, whether or not fitted with a filter (s) and optical component (s) (s), laser (s), LED (s), lens (s), mirror (s) and electrical (s) and / or magnetic component (s); (b) a light-emitting beam and / or light source with a light emission spectrum or similar device (s) selected within the range of the visible spectrum including violet, blue, green, yellow, orange and / or red, whether or not fitted with an optical filter (s) and optical component (s), laser (s), LED (s), lens (s), mirror (s) and component (s) electrical (s) and / or magnetic (s).

Phototherapy apparatus according to claim 01, characterized by lighting systems such as lasers and incandescent, dichroic, fluorescent and halogen lamps; organic, inorganic or hybrid LED type, or combinations of two or more different lamps combined in any configuration, arranged on beam phototherapy apparatus and / or luminous targets with the focus of illumination from the phototherapy source to the object of interest or region around you.

Phototherapy apparatus according to claims 01 and 02, characterized in that the object of interest has conditions of maximum light intensity or irradiance.

Phototherapy apparatus according to claims 01, 02 and 03, characterized in that it contains blue light and lighting systems based on flexible or rigid organic, inorganic or hybrid light-emitting devices capable of enclosing all or part of the object. of interest.

Phototherapy apparatus according to claims 01, 02, 03 and 04, characterized by beam-targeting and / or light targeting for enhancement of irradiance in infants undergoing phototherapeutic treatment of jaundice or neonatal hyperbilirubinemia.

Phototherapy apparatus according to claims 01, 02, 03, 04 and 05, characterized by beam direction and / or light targets in the form of a light film which is alternatively printed via silk screen, rotogravure, jet printing techniques. ink, or the like on a garment, such as pants, overalls, pajamas and blouses, and diapers.

Phototherapy apparatus according to claims 01, 02, 03, 04, 05 and 06, characterized by beam targeting and / or light targets operating on batteries, batteries, direct current (dc) sources and / or light sources. alternating current (ac).

Phototherapy apparatus according to claims 01, 02, 03, 04, 05, 06 and 07, characterized by the direction or not of a light beam and / or target in the form of a light film.

Phototherapy apparatus according to claims 01, 02, 03, 04, 05, 06, 07 and 08, characterized in that it involves the body of interest in the form of blanket type clothing or blankets or clothes in various shapes, including pajamas , blouses, overalls, pants, diapers.

Phototherapy apparatus according to claims 01, 02, 03, 04, 05, 06, 07, 08 and 09 characterized by beam direction and / or light targeting for dosing and evaluate the conditions of irradiation processes for sanitary, phytosanitary and or technological purposes.

Phototherapy apparatus according to claims 01, 02, 03, 04, 05, 06, 07, 08, 09 and 10, characterized in that it contains motor (s) and / or electronic device (s) and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or pattern recognition system (s) and / or systems newborn sensing and / or newborn motion detection system (s) in front of a light source to direct beam and / or light targets to or around the body of jaundiced patients do not.

Phototherapy device according to claims 01, 02, 03, 04, 05, 06, 07, 08, 09, 10 and 11, characterized in that it contains motor (s) and / or electronic device (s). and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or pattern recognition system (s) and / or sensing systems of patients with skin cancer, or other neoplasia, and / or motion detection system (s) of these patients in front of the light source to direct light beam and / or target to the body of cancer patients, or their surroundings, real time or not.

Irradiation equipment according to claims 01, 02, 03, 04, 05, 06, 07, 08, 09, 10, 11 and 12, characterized in that it contains motor (s) and / or electronic device (s) ( and / or optoelectronic device (s) and / or optical device (s) and / or image recognition system (s) and / or pattern recognition system (s) and / or sensing systems of patients with vitiligo and / or motion detection system (s) of these patients in front of the irradiation source for directing beam and / or light targets to or around their body in real time. or not.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12 and 13 characterized by directional beam or light targeting for artificial tanning machines.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13 and 14 characterized by directional beam and / or targeting of light sources in the treatment of vitiligo.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14 and 15 characterized by beam and / or light targeting directed to photodynamic therapy sources in the treatment of cancer patients.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15 and 16 characterized by beam beam and / or light targeting for inspection and / or evaluation of lighting conditions. in phototherapeutic treatment of jaundice, vitiligo, skin cancer and other dermatological diseases.

Use of the phototherapy apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15, 16 and 17, characterized in that the irradiance in patients undergoing radiation treatment, whether ionized or not, in hospitals , maternity wards, intensive care units and households.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15, 16, 17 and 18 characterized by beam and / or light targeting directed to UV radiation sources in the germicidal and bactericidal control.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15, 16, 17, 18 and 19 characterized by beam and / or targeting light sources for ionizing radiation in irradiation processes for therapeutic and aesthetic purposes.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20 characterized by directional beam and / or targeting to sources of ionizing radiation in processes of food irradiation for sanitary, phytosanitary purposes, budding inhibition and maturation delay.

Use of the irradiation apparatus according to claims 01, 02, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 and 21 characterized by light beam and / or targeting for ionizing radiation sources in flower irradiation processes for sanitary, phytosanitary, commercial and technological purposes.