WO2015066452A3 - Methods of treating pediatric cancers - Google Patents

Methods of treating pediatric cancers Download PDF

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Publication number
WO2015066452A3
WO2015066452A3 PCT/US2014/063384 US2014063384W WO2015066452A3 WO 2015066452 A3 WO2015066452 A3 WO 2015066452A3 US 2014063384 W US2014063384 W US 2014063384W WO 2015066452 A3 WO2015066452 A3 WO 2015066452A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
pediatric cancers
treating pediatric
treating
cancers
Prior art date
Application number
PCT/US2014/063384
Other languages
French (fr)
Other versions
WO2015066452A2 (en
Inventor
Siraj Mahamed ALI
Juliann CHMIELECKI
Matthew J. HAWRYLUK
Philip James STEPHENS
Kai Wang
Original Assignee
Foundation Medicine, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foundation Medicine, Inc. filed Critical Foundation Medicine, Inc.
Publication of WO2015066452A2 publication Critical patent/WO2015066452A2/en
Publication of WO2015066452A3 publication Critical patent/WO2015066452A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Methods and compositions for treating pediatric cancers are disclosed.
PCT/US2014/063384 2013-11-01 2014-10-31 Methods of treating pediatric cancers WO2015066452A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361898835P 2013-11-01 2013-11-01
US61/898,835 2013-11-01

Publications (2)

Publication Number Publication Date
WO2015066452A2 WO2015066452A2 (en) 2015-05-07
WO2015066452A3 true WO2015066452A3 (en) 2015-06-04

Family

ID=53005386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/063384 WO2015066452A2 (en) 2013-11-01 2014-10-31 Methods of treating pediatric cancers

Country Status (1)

Country Link
WO (1) WO2015066452A2 (en)

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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
DK3176170T3 (en) 2012-06-13 2019-01-28 Incyte Holdings Corp SUBSTITUTED TRICYCLIC RELATIONS AS FGFR INHIBITORS
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
ES2893725T3 (en) 2013-04-19 2022-02-09 Incyte Holdings Corp Bicyclic heterocyclics as FGFR inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
CN107438607B (en) 2015-02-20 2021-02-05 因赛特公司 Bicyclic heterocycles as FGFR inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
AU2017238390A1 (en) * 2016-03-23 2018-09-27 Dana-Farber Cancer Institute, Inc. Compositions, assays, and methods for targeting HDM2 and HDMX to reverse the inhibition of p53 in pediatric cancers
CN106011051B (en) * 2016-07-01 2020-01-21 中山大学 Application of Bend5 protein in improving differentiation of embryonic stem cells into primitive germ-like cells by induction
WO2018081204A1 (en) * 2016-10-26 2018-05-03 Li George Y DEUTERATED N-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL) PYRIDIN-2-YL)-5-FLUORO-4-(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[d]IMIDAZOL-6-YL)PYRIMIDIN-2-AMINE
ES2928773T3 (en) 2017-01-17 2022-11-22 Heparegenix Gmbh Protein kinase inhibitors to promote liver regeneration or reduce or prevent hepatocyte death
CN108794452B (en) 2017-05-05 2021-05-28 上海时莱生物技术有限公司 Compound with kinase inhibition activity, preparation method and application thereof
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
RU2020133814A (en) 2018-03-19 2022-04-19 Такеда Фармасьютикал Компани Лимитед METHODS FOR TREATMENT OF CANCER IN CHILDHOOD PATIENTS
MA52493A (en) 2018-05-04 2021-03-10 Incyte Corp FGFR INHIBITOR SALTS
BR112020022392A2 (en) 2018-05-04 2021-02-02 Incyte Corporation solid forms of a fgfr inhibitor and processes for preparing them
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
JP2020162420A (en) 2019-03-28 2020-10-08 シスメックス株式会社 Method for determining sensitivity of cyclin-dependent kinase 4/6 inhibitor, reagent kit, device and computer program
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CR20220169A (en) 2019-10-14 2022-10-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2023505258A (en) 2019-12-04 2023-02-08 インサイト・コーポレイション Tricyclic heterocycles as FGFR inhibitors
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
US20230340485A1 (en) * 2020-06-16 2023-10-26 Alnylam Pharmaceuticals, Inc. ANAPLASTIC LYMPHOMA KINASE (ALK) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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WO2012068030A1 (en) * 2010-11-15 2012-05-24 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble fgfr1 fusion proteins
WO2012108782A1 (en) * 2011-02-07 2012-08-16 Общество С Ограниченной Ответственностью "Онкомакс" Antibody that stops or slows tumour growth (variants)

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2012068030A1 (en) * 2010-11-15 2012-05-24 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble fgfr1 fusion proteins
WO2012108782A1 (en) * 2011-02-07 2012-08-16 Общество С Ограниченной Ответственностью "Онкомакс" Antibody that stops or slows tumour growth (variants)
US20140105821A1 (en) * 2011-02-07 2014-04-17 llya Valer'evich Tymofeev Antibody that stops or slows tumour growth (variants)

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LEW W ET AL.: "The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations", SCI SIGNAL, vol. 2, no. 58, 17 February 2009 (2009-02-17), pages RA6 1 - 11 *
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