WO2015057583A8 - Treatment of chronic kidney disease with sahps - Google Patents

Treatment of chronic kidney disease with sahps Download PDF

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Publication number
WO2015057583A8
WO2015057583A8 PCT/US2014/060304 US2014060304W WO2015057583A8 WO 2015057583 A8 WO2015057583 A8 WO 2015057583A8 US 2014060304 W US2014060304 W US 2014060304W WO 2015057583 A8 WO2015057583 A8 WO 2015057583A8
Authority
WO
WIPO (PCT)
Prior art keywords
chronic kidney
kidney disease
treat
polypeptides
disclosed
Prior art date
Application number
PCT/US2014/060304
Other languages
French (fr)
Other versions
WO2015057583A1 (en
Inventor
Peter Yuen
Ana SOUZA
Robert Star
Alexander BOCHAROV
Alan Remaley
Thomas EGGERMAN
Original Assignee
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America, As Represented By The Secretary, Department Of Health And Human Services filed Critical The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of WO2015057583A1 publication Critical patent/WO2015057583A1/en
Publication of WO2015057583A8 publication Critical patent/WO2015057583A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are polypeptides comprising or consisting of a synthetic amphipathic helical peptide or peptide analog, and nucleic acid molecules encoding such polypeptides. Also disclosed herein are methods of using the disclosed polypeptides, analogs, or nucleic acid molecules to treat and/or inhibit chronic kidney disease, as well as to treat and/or inhibit dyslipidemic or vascular disorders, such as methods to treat or prevent cardiovascular disease including atherosclerosis.
PCT/US2014/060304 2013-10-14 2014-10-13 Treatment of chronic kidney disease with sahps WO2015057583A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361890585P 2013-10-14 2013-10-14
US61/890,585 2013-10-14

Publications (2)

Publication Number Publication Date
WO2015057583A1 WO2015057583A1 (en) 2015-04-23
WO2015057583A8 true WO2015057583A8 (en) 2015-06-18

Family

ID=51794993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/060304 WO2015057583A1 (en) 2013-10-14 2014-10-13 Treatment of chronic kidney disease with sahps

Country Status (1)

Country Link
WO (1) WO2015057583A1 (en)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496668A (en) 1983-08-26 1985-01-29 Hercules Corporated Cellular thermoset poly(dicyclopentadiene)
DE3517281A1 (en) 1985-05-14 1986-11-20 Bayer Ag, 5090 Leverkusen ELECTROVISCOSE LIQUIDS
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US5091309A (en) 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
CA1257199A (en) 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
DE19931865A1 (en) 1999-07-09 2001-01-11 Schopf Maschb Gmbh Aircraft towing vehicle
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
US6527863B1 (en) 2001-06-29 2003-03-04 Advanced Cardiovascular Systems, Inc. Support device for a stent and a method of using the same to coat a stent
ATE469174T1 (en) 2004-10-15 2010-06-15 Us Gov Health & Human Serv AMPHIPATHIC HELIX-SHAPED MULTIDOMAIN PEPTIDES AND METHOD FOR USE THEREOF
US8936787B2 (en) 2008-04-15 2015-01-20 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Peptides promoting lipid efflux
US20100240598A1 (en) * 2009-03-16 2010-09-23 The Regents Of The University Of California Peptides and peptide mimetics to inhibit the onset and/or progression of fibrotic and/or pre-fibrotic pathologies
WO2011066511A1 (en) 2009-11-30 2011-06-03 The U.S.A., As Represented By The Secretary Department Of Health And Human Services Synthetic apoa-1 mimetic amphipathic peptides and methods of use thereof

Also Published As

Publication number Publication date
WO2015057583A1 (en) 2015-04-23

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