WO2015055156A1 - Dispositif mobile pour la surveillance à long terme des fonctions visuelles et cérébrales - Google Patents

Dispositif mobile pour la surveillance à long terme des fonctions visuelles et cérébrales Download PDF

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Publication number
WO2015055156A1
WO2015055156A1 PCT/CZ2014/000115 CZ2014000115W WO2015055156A1 WO 2015055156 A1 WO2015055156 A1 WO 2015055156A1 CZ 2014000115 W CZ2014000115 W CZ 2014000115W WO 2015055156 A1 WO2015055156 A1 WO 2015055156A1
Authority
WO
WIPO (PCT)
Prior art keywords
visual
electrode
carrier
previous
head
Prior art date
Application number
PCT/CZ2014/000115
Other languages
English (en)
Inventor
Jan Kremlacek
Miroslav Kuba
Frantisek Vit
Original Assignee
Univerzita Karlova V Praze, Lekarska Fakulta V Hradci Kralove
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ2013-791A external-priority patent/CZ304882B6/cs
Priority claimed from CZ2013-28622U external-priority patent/CZ26369U1/cs
Priority claimed from CZ2013-831A external-priority patent/CZ304875B6/cs
Application filed by Univerzita Karlova V Praze, Lekarska Fakulta V Hradci Kralove filed Critical Univerzita Karlova V Praze, Lekarska Fakulta V Hradci Kralove
Publication of WO2015055156A1 publication Critical patent/WO2015055156A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/378—Visual stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head

Definitions

  • the invention relates to a mobile device for long-term monitoring of visual and brain functions based on registration and analysis of electric potentials of the human brain, evoked by visual stimuli (so-called "visual evoked potentials" - VEPs).
  • EEG spontaneous electric activity of the brain
  • MindBand2 NeuroSky http://vvww.mindtecstore.corri/index.php/en/mindband
  • Neuroheadset Emotiv http://www.emotiv.com/
  • Muse Muse
  • Enobio Starlab http://neuroelectrics.com/enobio
  • VEPs registration was not used for these purposes so far because the following technical limitations of existing devices for VEPs examination do not enable it:
  • VEPs acquired by standard methods are recorded from the hairy (occipital) area of the head, which requires quite demanding professional application of the recording electrodes.
  • Visual stimulators which are currently used for testing of visual system and brain functions provide their activation via temporally-spatial modulation of light. Electric potentials recorded either from the retina (ERG) or from the cortical areas of the brain (VEPs) are evaluated-
  • ERG retina
  • VEPs cortical areas of the brain
  • visual stimulators in the form of glasses or other carriers adapted for wearing on the head (head carriers) that include light sources providing a visual stimulation (US 2009156886, GB 2352182), however, they do not produce usable visual stimuli for monitoring of visual sensation by means of brain electric activity recording.
  • the present invention provides a device for long-term monitoring of visual and brain functions, overcoming the drawbacks of the prior art devices.
  • the device contains a source of visual stimuli in the form of a set of light emitting diodes (LED) with the angle of irradiation being at least 80° and adjustable luminance that are mounted on fixation holders defining the angle of the LED irradiation to be between 60° and 80° relative to the horizontal plane.
  • the LEDs are arranged in one line on a carrier for placing the visual stimuli source on the upper edge of the visual field of the stimulated subject (person).
  • the device further includes a generator of the visual stimuli and a control and registration unit with amplifiers of the recorded signals and an analog-digital (A/D) converter.
  • A/D analog-digital
  • the carrier is also provided with two to four dry surface electrodes for recordings of VEPs, arranged in such a way that after placement of the carrier on the head the electrodes are in contact with the non-hairy forehead area of the stimulated subject.
  • the device may include bidirectional data interface for communication with a computer that controls visual stimulations and evaluates the recorded VEPs, or built-in microprocessor that controls visual stimulations and evaluates the recorded VEPs directly within the device.
  • a golf peak, a cap with a peak or a hat represent the carrier.
  • Stimulating LEDs have wide angle of light irradiation, at least 80°, in order to maintain the effectiveness of visual stimulation and thereby the amplitude of the recorded VEPs by different view directions of the monitored subject and also by different positions of the carrier (peak) on the head.
  • Suitable LED type (with the luminance of at least 1500 mcd) enables also to change automatically the luminance of stimulation within a wide range, according to light conditions in the background that are continuously monitored. It is namely important for evaluated parameters of VEPs to maintain approximately constant light contrast of the stimulation.
  • Dry surface electrodes (preferably of about 1 cm 2 ) are incorporated in the carrier in such a way that after its setting on the head, the electrodes are in good contact with the skin on the non-hairy forehead area of the subject, preferably in particular positions FP1 and FP2 according to the international system of electrode placement "10-20". This localisation is optimal for simple and non-professional applications.
  • the device also includes an integrated background luminance detector with an automatic regulator for continual control and adjustment of the visual stimuli luminance.
  • the device contains a reference electrode and an electrode for noise suppression of the recorded signal (CZ 302454).
  • the electrodes are incorporated in the opposite parts of an earlobe clip.
  • the earlobe clip includes only a reference electrode.
  • the earlobe clip thus realizes two electrodes at once and thus both sides of the earlobe are exploited.
  • the recorded signals (EEG) (from two to four unipolar channels) are preferably amplified by means of built-in amplifiers, preferably constructed according to the Czech patent CZ 302454 with an integrated A/D converter. These amplifiers are low-noise even with application of dry surface electrodes. Communication between the EEG amplifiers and the stimulator is ensured by the control and registration unit.
  • the mobile device is also provided with a 3D accelerometer, which enables to consider for the evaluation a possible influence of the subject mobility during the monitoring, in particular to detect such movements of the head which can significantly change the recorded EEG signal.
  • Data from the accelerometer are evaluated in the control computer or in the built-in microprocessor and on this basis transient interruption of visual stimulation and signal transmission can be done.
  • the device is provided with at least one dry electrode for registering VEPs having a substantially comb-like shape containing mutually conductively connected teeth, wherein the length of the teeth is at least 70% of the length of the entire electrode.
  • This shape allows easy application of the electrode to the hairy part of a scalp and a good contact with the skin.
  • the electrode is made from a conductive material (e.g., sheet metal, wire).
  • the material is flexible in order to adapt to the shape of the head.
  • This electrode is preferably arranged either on the carrier so that after the carrier is placed on the head, the electrode is in contact with the hairy part of the head; or it is arranged outside the carrier, but conductively connected to the data interface or the built-in microprocessor.
  • the teeth of the electrode are shaped to form at least one arc, thereby, the contact pressure to the scalp is ensured.
  • at least one tooth of the electrode is diverted in order to increase the contact pressure of the other teeth to the skin.
  • the edges of the comb electrode are preferably adjusted to avoid skin injuries, i.e. the edges are rounded.
  • Individual teeth of the comb electrode have preferably width in the range from 0.5 to 3 mm and their spacing is in the range from 0.5 to 3 mm, in order to ensure easy penetration of the comb electrode through hair with regard to the hair quality and thickness, and at the same time to maximize the connection surface formed by the comb electrode teeth contacting the skin.
  • the whole device is very light and simply and quickly usable. All its parts (with eventual incorporation of the control and evaluation unit) are incorporated into one carrier for placing on the head.
  • a fixing belt and a Velcro fastener enabling quick placement on the head of any size
  • exchangeable fixing belts for single user mode and a chemical disinfection of the recording electrodes.
  • Fig. 2 shows an embodiment of the electrode for registering VEPs having a substantially comb-like shape.
  • Fig 1 displays a mobile device for a long-term monitoring of visual and brain functions that on a carrier F includes a generator D of visual stimuli with a source A of visual stimuli in the form of light emitting diodes (LED) with the angle of irradiation of more than 80° and with adjustable luminance (luminance at least 1500 mcd).
  • LED light emitting diodes
  • adjustable luminance luminance at least 1500 mcd.
  • fixation holders with the angle of contact plane grinding of 60° to 80° are used and the LEDs are arranged on the carrier F at the border of the visual field of the stimulated subject.
  • the device further contains a control and registration unit C (includes EEG amplifiers, 3D accelerometer and a microprocessor for control and synchronisation of the device).
  • the carrier F is also provided with a bidirectional data interface B and with at least two active dry surface electrodes E for recording of visual evoked potentials (VEPs) which are arranged for being placed on the non-hairy frontal part of the subject's head after setting of the carrier F on the head.
  • the source A of visual stimuli, generator D of visual stimuli, control and registration unit C and bidirectional data interface B are supplied by electric power from a battery G fixed to the carrier F.
  • a golf peak serves as the carrier F.
  • the device further includes a reference electrode and an electrode for noise suppression in the recorded signal (see CZ 302454), both preferably placed in opposite sides of an earlobe clip L,
  • VEPs are transmitted via bidirectional data interface B to the control PC or they are evaluated by a microprocessor right in the device.
  • the device can be provided with at least one dry electrode i for registering VEPs, depicted in Fig. 2, having a substantially comb-like shape containing mutually conductively connected teeth 2, wherein the length c of the teeth 2 is at least 70% of the length b of the entire electrode.
  • This shape allows easy application of the electrode to the hairy part of a scalp and a good contact with the skin.
  • the electrode is made from a conductive material (e.g., sheet metal, wire).
  • the material is flexible in order to adapt to the shape of the head.
  • This electrode is preferably arranged either on the carrier so that after the carrier is placed on the head, the electrode is in contact with the hairy part of the head; or it is arranged outside the carrier, but conductively connected to the data interface or the built-in microprocessor.
  • Individual teeth 2 of the electrode have preferably rounded edges and width d in the range from 0.5 to 3 mm and their spacing e is in the range from 0.5 to 3 mm, in order to ensure easy penetration of the comb electrode through hair with regard to the hair quality and thickness, and at the same time to maximize the connection surface formed by the electrode teeth 2 contacting the skin.
  • Particularly preferable size of the electrode (a x b) is 20 x 23 mm with width d of the teeth 2 1 mm, length c of the teeth 2 18 mm and spacing e 1 mm.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention concerne un dispositif mobile pour une surveillance à long terme des fonctions visuelles et cérébrales, comprenant un support (F) soutenant un générateur (D) et une source (A) de stimuli visuels sous la forme de diodes électroluminescentes agencées de telle sorte que la source de stimuli visuels (A) soit sur la bordure du champ visuel du sujet stimulé, lorsque le dispositif est fixé sur sa tête. Elle comprend en outre une unité de commande et d'enregistrement (C) comprenant des amplificateurs du signal EEG enregistré, un convertisseur A/N et un microprocesseur d'évaluation ou une interface de données bidirectionnelle (B). Les LED de stimulation ont un angle de rayonnement d'au moins 80°, une luminance réglable, et sont assemblées au support (F) au moyen d'éléments de fixation la zone de contact formant un angle de 60° à 80°. Le support (F) comprend en outre deux à quatre électrodes actives à surfaces sèches (E) pour l'enregistrement des potentiels visuels évoqués, qui sont agencées de telle manière qu'après le placement du support (F) sur la tête, elles soient en contact avec la partie frontale non chevelue de la tête du sujet stimulé.
PCT/CZ2014/000115 2013-10-15 2014-10-15 Dispositif mobile pour la surveillance à long terme des fonctions visuelles et cérébrales WO2015055156A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CZ2013-791A CZ304882B6 (cs) 2013-10-15 2013-10-15 Mobilní zařízení pro dlouhodobé monitorování zrakových a mozkových funkcí
CZPUV2013-28622 2013-10-15
CZPV2013-791 2013-10-15
CZ2013-28622U CZ26369U1 (cs) 2013-10-15 2013-10-15 Mobilní zařízení pro dlouhodobé monitorování zrakových a mozkových funkcí
CZ2013-831A CZ304875B6 (cs) 2013-10-30 2013-10-30 Suchá elektroda pro registraci biopotenciálů z vlasaté části hlavy
CZPV2013-831 2013-10-30

Publications (1)

Publication Number Publication Date
WO2015055156A1 true WO2015055156A1 (fr) 2015-04-23

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WO (1) WO2015055156A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110612059A (zh) * 2017-05-02 2019-12-24 头部安全知识产权私人有限公司 头戴式设备
JP2021045424A (ja) * 2019-09-19 2021-03-25 ニッタ株式会社 脳波計測用ヘッドギア及び電極ユニット
US11020035B2 (en) 2016-02-01 2021-06-01 Epitel, Inc. Self-contained EEG recording system
US11633144B2 (en) 2020-04-05 2023-04-25 Epitel, Inc. EEG recording and analysis
EP4230128A1 (fr) * 2016-03-29 2023-08-23 Ceribell, Inc. Appareil de placement d'électrode
US11857330B1 (en) 2022-10-19 2024-01-02 Epitel, Inc. Systems and methods for electroencephalogram monitoring

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013584A1 (fr) * 1990-02-28 1991-09-19 Srd Shorashim Medical, Ltd. Appareil pour placer des electrodes
WO1999059470A1 (fr) * 1998-05-15 1999-11-25 Swinburne Limited Systeme d'evaluation de communication de masse
GB2352182A (en) 1999-06-05 2001-01-24 Peter Carr Photic stimulator with eye-movement cue
DE20300767U1 (de) * 2003-01-14 2003-03-20 Inst Agrar Und Stadtoekologisc Körperelektrode zur Messung elektrischer Potenziale auf einer mit Haaren oder Fell bewachsenen Hautoberfläche eines Lebewesens
WO2008077177A1 (fr) * 2006-12-22 2008-07-03 Neuro-Insight Pty. Ltd. Procédé pour évaluer des réponses psychologiques à des objets visuels
US20090156886A1 (en) 2007-12-12 2009-06-18 Synapse Research Company Method and apparatus for providing automatic eye focused therapy
WO2010147913A1 (fr) * 2009-06-15 2010-12-23 Brain Computer Interface Llc Batterie de test d'interface cerveau-ordinateur pour l'évaluation physiologique de la santé du système nerveux
US20110046503A1 (en) * 2009-08-24 2011-02-24 Neurofocus, Inc. Dry electrodes for electroencephalography
CZ302454B6 (cs) 2010-06-28 2011-05-25 Ceské vysoké ucení technické v Praze Fakulta elektrotechnická Systém pro merení biologických signálu s potlacením rušení
WO2012006972A1 (fr) * 2010-07-12 2012-01-19 Universita Karlova V Praze Lekarska Fakulta V Hradci Kralove Stimulateur visuel pour la surveillance à long terme d'une perception visuelle

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013584A1 (fr) * 1990-02-28 1991-09-19 Srd Shorashim Medical, Ltd. Appareil pour placer des electrodes
WO1999059470A1 (fr) * 1998-05-15 1999-11-25 Swinburne Limited Systeme d'evaluation de communication de masse
GB2352182A (en) 1999-06-05 2001-01-24 Peter Carr Photic stimulator with eye-movement cue
DE20300767U1 (de) * 2003-01-14 2003-03-20 Inst Agrar Und Stadtoekologisc Körperelektrode zur Messung elektrischer Potenziale auf einer mit Haaren oder Fell bewachsenen Hautoberfläche eines Lebewesens
WO2008077177A1 (fr) * 2006-12-22 2008-07-03 Neuro-Insight Pty. Ltd. Procédé pour évaluer des réponses psychologiques à des objets visuels
US20090156886A1 (en) 2007-12-12 2009-06-18 Synapse Research Company Method and apparatus for providing automatic eye focused therapy
WO2010147913A1 (fr) * 2009-06-15 2010-12-23 Brain Computer Interface Llc Batterie de test d'interface cerveau-ordinateur pour l'évaluation physiologique de la santé du système nerveux
US20110046503A1 (en) * 2009-08-24 2011-02-24 Neurofocus, Inc. Dry electrodes for electroencephalography
CZ302454B6 (cs) 2010-06-28 2011-05-25 Ceské vysoké ucení technické v Praze Fakulta elektrotechnická Systém pro merení biologických signálu s potlacením rušení
WO2012006972A1 (fr) * 2010-07-12 2012-01-19 Universita Karlova V Praze Lekarska Fakulta V Hradci Kralove Stimulateur visuel pour la surveillance à long terme d'une perception visuelle
CZ303192B6 (cs) 2010-07-12 2012-05-23 Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové Zrakový stimulátor

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11020035B2 (en) 2016-02-01 2021-06-01 Epitel, Inc. Self-contained EEG recording system
US11633139B2 (en) 2016-02-01 2023-04-25 Epitel, Inc. Self-contained EEG recording system
US11969249B2 (en) 2016-02-01 2024-04-30 Epitel, Inc. Self-contained EEG recording system
EP4230128A1 (fr) * 2016-03-29 2023-08-23 Ceribell, Inc. Appareil de placement d'électrode
CN110612059A (zh) * 2017-05-02 2019-12-24 头部安全知识产权私人有限公司 头戴式设备
JP7350257B2 (ja) 2019-09-19 2023-09-26 ニッタ株式会社 脳波計測用ヘッドギア
JP2021045424A (ja) * 2019-09-19 2021-03-25 ニッタ株式会社 脳波計測用ヘッドギア及び電極ユニット
US11633144B2 (en) 2020-04-05 2023-04-25 Epitel, Inc. EEG recording and analysis
US11779262B2 (en) 2020-04-05 2023-10-10 Epitel, Inc. EEG recording and analysis
US11786167B2 (en) 2020-04-05 2023-10-17 Epitel, Inc. EEG recording and analysis
US11638551B2 (en) 2020-04-05 2023-05-02 Epitel, Inc. EEG recording and analysis
US11857330B1 (en) 2022-10-19 2024-01-02 Epitel, Inc. Systems and methods for electroencephalogram monitoring
US11918368B1 (en) 2022-10-19 2024-03-05 Epitel, Inc. Systems and methods for electroencephalogram monitoring

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