WO2015050957A3 - Treatments for systemic lupus erythematosus - Google Patents

Treatments for systemic lupus erythematosus Download PDF

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Publication number
WO2015050957A3
WO2015050957A3 PCT/US2014/058576 US2014058576W WO2015050957A3 WO 2015050957 A3 WO2015050957 A3 WO 2015050957A3 US 2014058576 W US2014058576 W US 2014058576W WO 2015050957 A3 WO2015050957 A3 WO 2015050957A3
Authority
WO
WIPO (PCT)
Prior art keywords
lupus erythematosus
systemic lupus
treatments
elf4
bankl
Prior art date
Application number
PCT/US2014/058576
Other languages
French (fr)
Other versions
WO2015050957A2 (en
WO2015050957A8 (en
Inventor
Marta E. ALARCON RIQUELME
Ying Yu
Ramesh Kumar
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Publication of WO2015050957A2 publication Critical patent/WO2015050957A2/en
Publication of WO2015050957A8 publication Critical patent/WO2015050957A8/en
Publication of WO2015050957A3 publication Critical patent/WO2015050957A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The disclosure involves the identification of the Eukaryotic initiation factor 4 (elF4) machinery as a downstream effector of the B-cell scaffold protein with ankyrin repeats 1 (Bankl )-mediated regulation of IL-6 expression. Thus, methods for treating patients suffering from autoimmune diseases such as systemic lupus erythematosus by targeting elF4 function are provided.
PCT/US2014/058576 2013-10-02 2014-10-01 Treatments for systemic lupus erythematosus WO2015050957A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361885859P 2013-10-02 2013-10-02
US61/885,859 2013-10-02

Publications (3)

Publication Number Publication Date
WO2015050957A2 WO2015050957A2 (en) 2015-04-09
WO2015050957A8 WO2015050957A8 (en) 2015-09-11
WO2015050957A3 true WO2015050957A3 (en) 2015-11-12

Family

ID=52779279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/058576 WO2015050957A2 (en) 2013-10-02 2014-10-01 Treatments for systemic lupus erythematosus

Country Status (1)

Country Link
WO (1) WO2015050957A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015317741B2 (en) 2014-09-17 2020-01-16 Bristol-Myers Squibb Company MK2 inhibitors and uses thereof
CN105902533B (en) * 2016-05-23 2018-04-20 浙江省医学科学院 Purposes of the compound cercosporamide in immunopotentiator is prepared
EP4069268A4 (en) * 2019-12-02 2023-10-18 New York University Selective inhibition of t follicular helper cells for treatment of autoimmune disorders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090148462A1 (en) * 2005-10-13 2009-06-11 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US20110224223A1 (en) * 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
US20130209578A1 (en) * 2010-08-11 2013-08-15 Universite De Montreal Combinatory Cancer Treatment
US20130209543A1 (en) * 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090148462A1 (en) * 2005-10-13 2009-06-11 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US20110224223A1 (en) * 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
US20130209578A1 (en) * 2010-08-11 2013-08-15 Universite De Montreal Combinatory Cancer Treatment
US20130209543A1 (en) * 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GROLLEAU ET AL.: "Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients.", J CLIN INVEST., vol. 106, no. 12, 2000, pages 1561 - 1568, XP055235484 *
LOPEZ-PELAEZ ET AL.: "Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages", MOL BIOL CELL ., vol. 23, no. 15, August 2012 (2012-08-01), pages 2982 - 2992, XP055235483 *
WU ET AL.: "BANK1 controls CpG-induced IL -6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.", J IMMUNOL., vol. 191, no. 12, December 2013 (2013-12-01), pages 6110 - 6, XP055235488, DOI: doi:10.4049/jimmunol.1301203 *

Also Published As

Publication number Publication date
WO2015050957A2 (en) 2015-04-09
WO2015050957A8 (en) 2015-09-11

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