WO2015050744A3 - Neurogenesis screening method and uses thereof - Google Patents

Neurogenesis screening method and uses thereof Download PDF

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Publication number
WO2015050744A3
WO2015050744A3 PCT/US2014/057004 US2014057004W WO2015050744A3 WO 2015050744 A3 WO2015050744 A3 WO 2015050744A3 US 2014057004 W US2014057004 W US 2014057004W WO 2015050744 A3 WO2015050744 A3 WO 2015050744A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurogenesis
methods
screening method
adscs
oxysterol
Prior art date
Application number
PCT/US2014/057004
Other languages
French (fr)
Other versions
WO2015050744A2 (en
Inventor
Chenzhong KUANG
Yan XIAO
Dirk HONDMANN
Eduard K. POELS
Zeina Jouni
Original Assignee
Mjn U.S. Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/044,913 external-priority patent/US20140179775A1/en
Priority claimed from US14/044,918 external-priority patent/US20140179782A1/en
Priority claimed from US14/044,916 external-priority patent/US9351978B2/en
Application filed by Mjn U.S. Holdings Llc filed Critical Mjn U.S. Holdings Llc
Publication of WO2015050744A2 publication Critical patent/WO2015050744A2/en
Publication of WO2015050744A3 publication Critical patent/WO2015050744A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided herein are methods for detecting and/or confirming the neurogenesis effect of cholesterol, at least one oxysterol, EPA, EGCG and/or resveratrol utilizing adipose-derived stem cells (ADSCs). Further provided are methods of promoting neurogenesis in ADSCs. Also provided are methods for the use of cholesterol, an oxysterol, EPA, EGCG and/or resveratrol for the production of a neurologic component that may be incorporated into a nutritional composition for promoting neurogenesis in a pediatric subject.
PCT/US2014/057004 2013-10-03 2014-09-23 Neurogenesis screening method and uses thereof WO2015050744A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14/044,916 2013-10-03
US14/044,913 US20140179775A1 (en) 2012-02-29 2013-10-03 Neurogenesis screening method and uses thereof
US14/044,913 2013-10-03
US14/044,918 2013-10-03
US14/044,918 US20140179782A1 (en) 2011-10-14 2013-10-03 Neurogenesis screening method and uses thereof
US14/044,916 US9351978B2 (en) 2012-02-29 2013-10-03 Neurogenesis screening method and uses thereof

Publications (2)

Publication Number Publication Date
WO2015050744A2 WO2015050744A2 (en) 2015-04-09
WO2015050744A3 true WO2015050744A3 (en) 2015-06-11

Family

ID=52779271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/057004 WO2015050744A2 (en) 2013-10-03 2014-09-23 Neurogenesis screening method and uses thereof

Country Status (2)

Country Link
TW (1) TW201608026A (en)
WO (1) WO2015050744A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105232525A (en) * 2015-10-08 2016-01-13 成都普瑞法科技开发有限公司 Hypolipidemic drug combination and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010065567A2 (en) * 2008-12-01 2010-06-10 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
WO2013055439A1 (en) * 2011-10-14 2013-04-18 Mead Johnson Nutrition Company Nutritional phytonutrient compositions
US20130224862A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
US20130224782A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Neurogenesis screening method and system using adipose tissue derived stem cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61701B1 (en) 1986-07-17 1994-11-30 Morinaga Milk Industry Co Ltd Process for producing bovine lactoferrin in high purity
US5407957A (en) 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
DK165090D0 (en) 1990-07-09 1990-07-09 Kem En Tec As CONLOMERATED PARTICLES
AU661297B2 (en) 1991-01-24 1995-07-20 Martek Corporation Microbial oil mixtures and uses thereof
US5374567A (en) 1993-05-20 1994-12-20 The United States Of America As Represented By The Secretary Of The Navy Operational amplifier using bipolar junction transistors in silicon-on-sapphire
EP1142484A2 (en) 1994-02-16 2001-10-10 Pharming Intellectual Property BV Isolation of lactoferrin from milk
SE9503926D0 (en) 1995-11-07 1995-11-07 Pharmacia Biotech Ab Adsorption process and separation medium
WO1999065586A2 (en) 1998-06-18 1999-12-23 Upfront Chromatography A/S Expanded bed adsorption system
AU5823801A (en) 2000-05-12 2001-11-20 Upfront Chromatography As A bed adsorption system
US6332533B1 (en) 2000-08-29 2001-12-25 H.H.H. Incorprorated Media holder mouse pad
WO2002096215A1 (en) 2001-06-01 2002-12-05 Upfront Chromatography A/S Fractionation of protein containing mixtures
DK1480524T3 (en) 2002-03-07 2013-07-15 Upfront Chromatography As Method for isolating lactoferrin
US7951410B2 (en) 2003-04-14 2011-05-31 Mead Johnson Nutrition Company Enteral compositions containing caseinoglycomacropeptide having an enhanced concentration of sialic acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010065567A2 (en) * 2008-12-01 2010-06-10 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
WO2013055439A1 (en) * 2011-10-14 2013-04-18 Mead Johnson Nutrition Company Nutritional phytonutrient compositions
US20130224862A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
US20130224782A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Neurogenesis screening method and system using adipose tissue derived stem cells

Also Published As

Publication number Publication date
WO2015050744A2 (en) 2015-04-09
TW201608026A (en) 2016-03-01

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