WO2015047902A1 - Compounds and their use for preparation of tau imaging agents and tau imaging formulations - Google Patents
Compounds and their use for preparation of tau imaging agents and tau imaging formulations Download PDFInfo
- Publication number
- WO2015047902A1 WO2015047902A1 PCT/US2014/056503 US2014056503W WO2015047902A1 WO 2015047902 A1 WO2015047902 A1 WO 2015047902A1 US 2014056503 W US2014056503 W US 2014056503W WO 2015047902 A1 WO2015047902 A1 WO 2015047902A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- tau
- pyrido
- tert
- Prior art date
Links
- JOXIMZWYDAKGHI-UHFFFAOYSA-N Cc(cc1)ccc1S(O)(=O)=O Chemical compound Cc(cc1)ccc1S(O)(=O)=O JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- OEERRCRYAVSBCY-UHFFFAOYSA-N CC(C)(C)OC([n]1c(cc(cc2)-c(cc3)cnc3[N](C)(C)C)c2c2cnccc12)=O Chemical compound CC(C)(C)OC([n]1c(cc(cc2)-c(cc3)cnc3[N](C)(C)C)c2c2cnccc12)=O OEERRCRYAVSBCY-UHFFFAOYSA-N 0.000 description 1
- GETAAWDSFUCLBS-UHFFFAOYSA-N Fc(cc1)ncc1-c1ccc(c2cnccc2[nH]2)c2c1 Chemical compound Fc(cc1)ncc1-c1ccc(c2cnccc2[nH]2)c2c1 GETAAWDSFUCLBS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
Definitions
- the present invention relates to novel trimethylammonium compounds, to methods of using the compounds for preparation of the tau imaging agent [ 18 F]T807, and to compositions and formulations of those preparations for diagnostic imaging, and to methods of imaging using those compounds, compositions, and formulations.
- AD Alzheimer's disease
- a leading cause of dementia develops in one percent of the population between the ages 65 and 69, and increasing to 40-50% in those 95 years and older.
- AD patients exhibit telltale clinical symptoms that include cognitive impairment and deficits in memory function.
- the mature senile plaques consist of intracellular neurofibrillary tangles (NFT) derived from filaments of hyperphosphorylated tau proteins, and extracellular ⁇ -amyloid peptides derived from enzymatic processing of amyloid precursor protein.
- NFT neurofibrillary tangles
- HPF-tau hyperphosphorylated tau
- neurofibrillary tangles are linked to the degree of cognitive impairment in Alzheimer's disease.
- PHF-tau hyperphosphorylated tau
- [ 18 F]T807 is a PET imaging agent with demonstrated high affinity and selectivity to PHF-tau, as well as favorable in vivo properties.
- [ 18 F]T807 is useful for detecting and/or quantitation of tau deposits in patients (Early clinical PET imaging results with the novel PHF-tau radioligand [F-18J-T807, Chien et al., J Alzheimers Dis. 2013 Jan l;34(2):457-68).
- tau imaging will improve diagnosis by identifying potential patients, those having high levels of tau in the brain, who may have increased chance of developing AD.
- Imaging with [ 18 F]T807 will also be useful to monitor tau accumulation, and or progression of AD, and when anti-tau drug treatments become available, tau imaging may provide an essential tool for monitoring treatment.
- 5H-pyrido[4,3-b]indole-5-carboxylate is radiolabeled via reaction with 18 F with an isocratic HPLC purification (J. Label Compd. Radiopharm (2013)).
- Xia et al. recites a method wherein the precursor compound is 7-(6-nitropyridin-3-yl)-5H- pyrido[4,3-b]indole, shown below.
- Xia et al. recites that 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole is radiolabeled with 18 F using a second step with iron powder/formic acid, in a separate vial, to reduce the nitro group on the remaining precursor to the respective 2-amino-pyridine derivative, thus facilitating separation by HPLC ([(18)F]T807, a novel tau positron emission tomography imaging agent or Alzheimer's disease. Alzheimer's & Dementia (Feb. 2013) 1-11, available online at http://dx.doi.Org/10.1016/j.jalz.2012.l l.008).
- radiochemistry and/or radiopharmaceutical properties would be useful for clinical tau imaging. This technology would enhance detection, diagnosis, monitoring and/or
- the present invention provides the use of compounds of formula I, la, or lb, for the manufacture of a radiopharmaceutical agent [ 18 F]T807 for imaging of tau in humans.
- the invention provides methods of preparing compounds of formula I, la, or lb.
- the invention provides methods of preparing [ F]T807 from compounds of formula I, la, or lb. Particularly preferred is the method of preparing [ 18 F]T807 from the compound of formula la.
- the invention provides a pharmaceutical composition comprising [ 18 F]T807 prepared from a compound of formula I, la, or lb, and a pharmaceutically acceptable diluent or carrier.
- the invention provides a pharmaceutical composition
- a pharmaceutical composition comprising [ 18 F]T807 prepared from a compound of formula I, la, or lb, which is formulated in 10% (v/v) ethanol/90% w/v (0.9% aqueous Sodium
- Chloride preferably for use in humans.
- the present invention also provides methods of imaging tau comprising introducing into a patient a detectable quantity of [ 18 F]T807 prepared from a compound of formula I, la, or lb, or a composition thereof.
- the present invention provides a compound of formula I:
- anion is a suitable anionic counterion.
- Suitable anionic counterions include non- nucleophilic anions such as organic sulfonates or tartrate.
- the organic sulfate is preferably an alkyl sulfonate or aryl sulfonate.
- the present invention further provides a compound of formula I wherein [anion] " is an alkyl sulfonate or aryl sulfonate.
- Alkyl sulfonates of the present invention include CrC 4 alkyl sulfonate.
- Aryl sulfonates of the present invention include phenyl sulfonate, wherein the phenyl group is optionllay substituted once with CrC 4 alkyl, halogen or nitro.
- Particular values of C C 4 alkyl sulfonate include methanesulfonate (mesylate) and ethanesulfonate.
- phenyl sulfonate examples include benzenesulfonate, 4-methylbenzenesulfonate (tosylate), 4-bromobenzenesulfonate and 4-nitrobenzenesulfonate.
- Another suitable anionic counterion is trifluoromethylsulfonate (CF 3 SO 3 ).
- a preferred species of the present invention is a compound of formula la wherein ] " is 4-methylbenzenesulfonate.
- a preferred species of the present invention is a compound of formula lb wherein [anion] " is methanesulfonate.
- the compounds of formulae I, Ia and Ib are useful, for example, to synthesize a compound of formula II.
- the compound of formula II is also referred to as [ F]T807.
- the present invention provides a compound of formula II prepared from a compound of formula I: [ 18 F] fluoride
- the invention further provides a compound of formula II prepared from a compound of formula la or formula lb.
- the present invention provides a process of making a compound of the formula:
- a compound of formula II may be prepared from a compound of formula I. More specifically as shown in Scheme 1, a compound of formula la is first reacted with a suitable source of [ F]fluoride such as Cryptand 2.2.2-K 2 C0 3 [ F]fluoride in the presence of a base such as potassium carbonate. The reaction is conveniently carried out in a solvent such as
- a compound of formula I may be prepared from a compound of formula III. More specifically, a compound III is reacted with an activator such as p-toluenesulfonic anhydride (tosic anhydride) or trifluoroacetic anhydride and trimethyl amine in a solvent such as methylene chloride to provide a compound of formula la where [anion] ⁇ is 4- methylbenzenesulfonate, or alternatively trifluoro acetate.
- an activator such as p-toluenesulfonic anhydride (tosic anhydride) or trifluoroacetic anhydride and trimethyl amine in a solvent such as methylene chloride
- a solvent such as methylene chloride
- a compound of formula IV is reacted with bis(pinacolato)diboron in the presence of a transition metal catalyst such as dichloro l,l'-bis(diphenylphosphino)ferrocene palladium (II) dichloromethane adduct in dioxane.
- a transition metal catalyst such as dichloro l,l'-bis(diphenylphosphino)ferrocene palladium (II) dichloromethane adduct in dioxane.
- the resulting pinacol ester intermediate is reacted with 3-bromo-pyridine 1 -oxide in the presence of a catalyst such as palladium(II) tetrakistriphenylphosphine and a base such as aqueous sodium carbonate to provide a compound of formula III.
- the reaction is conveniently carried out in a solvent such as methylene chloride.
- the compounds of the present invention are preferably formulated as
- radiopharmaceutical compositions administered by a variety of routes.
- such compositions are for intravenous use.
- Such pharmaceutical compositions and processes for preparing same are well known in the art. See, e.g., Remington: The Science and Practice of Pharmacy (A. Gennaro, et ah, eds., 19 th ed., Mack Publishing Co., 1995).
- Preferred formulations of the present invention are preparations of [ 18 F]T807 prepared from compounds of formula I, and particularly preferred are formulations of
- [ 18 F]T807 prepared from the compound of formula la Particularly preferred is [ 18 F]T807 prepared from the compound of formula la according to the procedures described herein according to Scheme 1. Particularly preferred is [ 18 F]T807 prepared from the compound of formula la according to the procedures described herein according to Example 1 and
- Example 2 A preferred formulation of [ 18 F]T807 is prepared from a compound of formula I and formulated in 10% (v/v) ethanol/90% w/v (0.9% aqueous Sodium Chloride). A particularly preferred formulation of [ 18 F]T807 is prepared from the compound of formula la and formulated in 10% (v/v) ethanol/90% w/v (0.9% aqueous Sodium Chloride). A preferred formulation of [ 18 F]T807 is prepared from a compound of formula I and formulated in 10%
- a preferred formulation of [ 18 F]T807 is prepared from a compound of formula la and formulated in 10% (v/v) ethanol/90% (21 mM sodium phosphate).
- Another embodiment of the invention is a formulation of [ 18 F]T807 prepared from the compound of formula la and formulated in 9% (v/v) ethanol, 1% (w/v) Kolliphor HS 15, and 90% (v/v) (0.9% aqueous Sodium Chloride). Particularly preferred is
- [ 18 F]T807 prepared from the compound of formula la according to the procedures described herein according to Example 1 and Example 2 and formulated in 10% (v/v) ethanol/90% w/v (0.9% aqueous Sodium Chloride).
- Novel trimethylammonium compounds of the present invention have been discovered to be surprisingly and unexpectedly advantageous for use as synthetic precursors for the radiosynthesis of [ 18 F]T807 for imaging uses, including human clinical imaging.
- a preferred compound, the compound of formula la possesses a combination of particularly useful properties as a precursor for synthesis of [ 18 F]T807, including solubility, reactivity, shorter reaction times, separability, and yield. This surprisingly advantageous combination of improved properties leads to an effective and efficient clinical process for radiosynthesis of
- [ 18 F]T807 which facilitates imaging of patients for tau burden.
- the solubility of the precursor compound affects the ability of the compound to get into solution so that a reaction to produce [ 1 i 8 O F]T807 can effectively occur.
- the compound of formula la is readily soluble in DMSO, and therefore does not require sonication or heating to get the compound into solution, as is required for prior methods using the precursor 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole.
- Production failures are a known problem in the clinical practice of radiosynthesis and can limit the number of batches that can be prepared on a daily basis, and thus limit the number of patients that can be imaged in a window of time. Production failures thus can have important impact on the cost, accessibility, and convenience of patient imaging.
- Yield is another important aspect of a clinical radiosynthetic process for preparation of [ 18 F]T807.
- the process using the compound of formula la results in clinically useful yields.
- bromo or chloro substituted precursors have very low corrected yields ( ⁇ 5%), as the bromo and chloro substituents are not readily displaceable under normal, no carrier added, nucleophilic aromatic fluorination conditions. While this aspect alone is significant and important, this property, when discovered to be in combination with other advantageous properties of the compound of formula la, results in surprising improvements in clinical radiosynthetic processes for preparation of [ 18 F]T807.
- product yields can be negatively impacted by the difficulty to destroy the left over un-reacted 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole.
- the iron- process using 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole to produce [ 18 F]T807 at two different production sites corrected yields are obtained of 42%, 48% and 25% at Culver City, and 8%, 6% and 19% at Northwales.
- the Siemens non-iron process results in corrected yields of 71%, 45%, 70%, 55% and 54%.
- [ 18 F]T807 using 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole requires destruction of leftover un-reacted 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole in order to facilitate chromatographic purification of the product [ 18 F]T807. This is because 7-(6-nitropyridin-3- yl)-5H-pyrido[4,3-b]indole and [18F]T807 have similar chromatography properties making it challenging to separate one from the other.
- [ 18 F]T807 and by-product generated using the compound of formula la precursor also facilitate the use of cartridge- based purification as opposed to more tedious and time consuming HPLC processes.
- use of the compound of formula la can also simplify the production process. These differences can result in significantly faster overall production times, and increases clinical radiosynthesis production capacity, which can have important positive impact on the cost, accessibility, and convenience of patient imaging.
- the present process using the compound of formula la has unexpected and important real world advantages for the reliability and production capacity in clinical radiosynthesis of [ 18 F]T807 imaging doses. More batches, from improved capacity and reliability, can have important positive impact on the ability to image tau in patients.
- Figure 1 HPLC peak matching profile of 7-[ 18 F]fluoro-5H-pyrido[4,3-b]indole,
- Upper panel labelled [ 18 F]T807 illustrates the radio- chromatogram of 7-(6-[ 18 F]fluoro-3-pyridyl)-5H-pyrido[4,3-b]indole, [ 18 F]T807.
- Lower panel labelled T807 illustrates the ultraviolet chromatogram of 7-(6- [ 18 F]fluoro-3-pyridyl)-5H-pyrido[4,3-b]indole, [ 18 F]T807.
- Figure 2 [ 18 F]T807 labeling of tau in post-mortem frontal lobe sections (10 um) of Tau positive human brain tissue from patients with AD, approximately 20 uCi of
- [ 18 F]T807 per slide Strong autoradiography signal of [ 18 F]T807 is observed on the grey matter (GM) region, and the presence of tau in these regions are confirmed by tau- immuno staining.
- the non-specific or background [ 18 F]T807 signal is shown in the white matter region (WM) and is low.
- the specificity of the autoradiography signal, with respect to binding to native tau aggregates, is indicated by the blocking effect of 1 uM of cold T807.
- Elemental analysis is performed at Galbraith Laboratories (GLI) (Galbraith Inc., 2323 Sycamore Drive, Knoxville, TN 37921) using GLI Procedure ME- 12 and palladium analysis is performed using GLI Procedure ME-70 (inductively coupled plasma optical emission spectrometry using an Optima 5300 ICP OES analyzer or equivalent) with results reported in ppm (Ref: Galbraith Inc., 2323 Sycamore Drive,
- the names for the compounds of the present invention are generated using Symyx Version 3.2.NET with the IUPAC naming functionality.
- the salts are washed with alternating portions of methylene chloride (2 x 250 mL) and methanol (2 x 250 mL), concentrated, and preabsorbed onto approximately 65 g silica gel.
- the material is divided and purified on two 330 g silica gel flash columns using a gradient of 100:0 (2 minute hold) to 95:5 methylene chloride: methanol over 10 minutes (8 minute hold) then increasing directly to 90: 10 methylene chloride: methanol (25 minute hold).
- the material is concentrated and dried under high vacuum to afford a grey-black solid (9.01 g, 31%).
- the reaction mixture is concentrated to a light yellow solid under reduced pressure.
- the solid is slurried in methylene chloride (500 mL) and extracted two times with water (300 mL, 200 mL).
- the aqueous layers are combined and extracted with methylene chloride (2 x 200 mL).
- the combined organic phases are dried over sodium sulfate, filtered, and concentrated to a tan/orange solid.
- the solids are dissolved in methylene choride (75 mL) and added dropwise to rapidly stirring diethyl ether (600 mL).
- the resulting solids are isolated by filtration and washed with diethyl ether.
- the trituration process is repeated 1 to 3 more times as necessary to remove any additional tosyl-related impurities.
- the material is further purified on a 40 g silica gel column (2-4 g compound) using a gradient of 100:0 (3 minute hold) to 90: 10 methylene chloride: methanol over 3 minutes with a 3 minute hold followed by increasing to 80:20 methylene
- the title compound is prepared using an automated radiosynthesizer such as a GE TRACERlab FX F _ N automated radiosynthesizer.
- Typical decay corrected yield is 45-55% [ F] Fluoride activity is retained on a Sep-Pak® Light AccellTM Plus (QMA) Carbonate Cartridge (46 mg Sorbent per Cartridge, 40 ⁇ Particle Size) and eluted to the reaction vessel using 0.8 mL of an aqueous Cryptand 2.2.2-K 2 C0 3 solution [Cryptand 2.2.2 (7 mg) and potassium carbonate (0.75 mg) in WFI (water for injection, 0.4 mL) and acetonitrile (0.4 mL)] .
- the eluted activity is dried by heating at 70 °C under nitrogen flow and vacuum for 4.5 minutes. The temperature is then raised to 100 °C and kept for an additional minute. Nitrogen flow is turned off and the activity is dried under vacuum for 4 minutes to afford
- the crude title compound is neutralized with 7 mL of 0.5 M NaOH (aq) (3.5 mL of 1 N NaOH (aq) and with 3.5 mL of water for injection, WFI).
- the resulting mixture is passed through an Oasis® HLB Light reversed-phase cartridge (30 mg Sorbent per Cartridge, 30 ⁇ Particle Size).
- the retained crude title compound is washed with WFI (5 mL) then eluted off the Oasis HLB Light cartridge using acetonitrile (1.5 mL).
- the crude material is diluted with WFI (3 mL) then loaded onto a semi-preparative C- 18 reversed-phase HPLC column
- the HPLC fraction containing the title compound is collected and diluted with 30 mL of WFI.
- the diluted solution is then passed through a Sep-Pak Light CI 8 reversed-phase Cartridge (130 mg Sorbent per Cartridge, 55-105 ⁇ Particle Size) and the retained title compound is washed with 5 mL of WFI.
- 18 F-AV- 1451 is eluted off the Sep-Pak C18 Plus Light cartridge using dehydrated alcohol, USP (1 mL) followed by 0.9% Sodium Chloride Injection, USP (2 mL) into 0.9% Sodium Chloride Injection, USP (7 mL).
- the drug substance solution is transferred into the bulk product vial (BPV) through a 0.22 um sterilizing filter (Millex GV PVDF, Millipore SLGV013SL).
- the HPLC method of analysis utilizes isocratic elution with a 25%:75% v/v acetonitrile: water with 0.1% TFA mobile phase on a C18 reversed-phase HPLC column with a flow rate of 1.0 mL/min.
- Two detectors, a radiometric detector and a UV detector set at 270 nm, are fitted to the system. Injections of Reference Standard solutions and Drug Product sample are made. The peaks from the UV chromatograms and radiochromatogram are integrated, and the data is used to calculate the radiochemical purity and specific activity and confirm the radiochemical identity. The identity of the title compound is confirmed by
- PBS lX-phospate buffered saline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016516543A JP2016531851A (en) | 2013-09-26 | 2014-09-19 | Novel compounds and uses for the preparation of tau imaging agents, and tau imaging formulations |
CA2920402A CA2920402A1 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
CN201480053230.2A CN105579454A (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of Tau imaging agents and Tau imaging formulations |
EA201690294A EA028426B1 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
MX2016003725A MX2016003725A (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations. |
KR1020167007637A KR101808969B1 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
US15/022,657 US20160228586A1 (en) | 2013-09-26 | 2014-09-19 | Compounds and Their Use for Preparation of Tau Imaging Agents and Tau Imaging Formulations |
EP14783708.2A EP3049414A1 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
AU2014327076A AU2014327076B2 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
HK16110824.3A HK1222654A1 (en) | 2013-09-26 | 2016-09-13 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations tau tau |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361882769P | 2013-09-26 | 2013-09-26 | |
US61/882,769 | 2013-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015047902A1 true WO2015047902A1 (en) | 2015-04-02 |
Family
ID=51690452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/056503 WO2015047902A1 (en) | 2013-09-26 | 2014-09-19 | Compounds and their use for preparation of tau imaging agents and tau imaging formulations |
Country Status (13)
Country | Link |
---|---|
US (1) | US20160228586A1 (en) |
EP (1) | EP3049414A1 (en) |
JP (1) | JP2016531851A (en) |
KR (1) | KR101808969B1 (en) |
CN (1) | CN105579454A (en) |
AR (1) | AR097683A1 (en) |
AU (1) | AU2014327076B2 (en) |
CA (1) | CA2920402A1 (en) |
EA (1) | EA028426B1 (en) |
HK (1) | HK1222654A1 (en) |
MX (1) | MX2016003725A (en) |
TW (1) | TW201605852A (en) |
WO (1) | WO2015047902A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106588915B (en) * | 2016-10-26 | 2018-12-04 | 浙江大学 | The synthetic method of Alzheimer's disease Protein tau diagnosis and treatment one targeted drug precursor |
ES2965049T3 (en) * | 2017-07-12 | 2024-04-10 | Dana Farber Cancer Inst Inc | Compounds for the degradation of tau protein |
TWI653052B (en) | 2017-11-17 | 2019-03-11 | 國立臺灣大學 | Preparation of [18f] t807 derivatives and uses thereof |
KR102215255B1 (en) | 2019-06-12 | 2021-02-15 | 한국과학기술연구원 | Novel compounds useful as fluorescent probes selectively binding to tau aggregates and preparation method thereof |
CN114539250B (en) * | 2022-03-04 | 2023-08-29 | 上海裕兰生物科技有限公司 | Preparation method of Alzheimer's disease PET-tau tracer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013017585A1 (en) * | 2011-08-01 | 2013-02-07 | Abx Advanced Biochemical Compounds Gmbh | Precursor compounds for the radiosynthesis of [18f] norchloro-fluorohomoepibatidine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4212595A1 (en) * | 1992-02-19 | 1993-08-26 | Bayer Ag | METHOD FOR PRODUCING 2-CHLORINE-5-METHYL-PYRIDINE |
DE4311247A1 (en) * | 1993-04-06 | 1994-10-13 | Bayer Ag | Process for the preparation of 2-halogenopyridine derivatives |
US8932557B2 (en) * | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
GB0905438D0 (en) * | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
CN102573475B (en) * | 2009-08-14 | 2016-01-20 | 欧科生医股份有限公司 | The iv formulation of neurokinine-1 antagonist |
EP2686302B1 (en) * | 2011-03-16 | 2016-08-10 | Mitsubishi Tanabe Pharma Corporation | Sulfonamide compounds having trpm8 antagonistic activity |
KR101353443B1 (en) * | 2012-02-07 | 2014-01-29 | 주식회사 아미팜 | Injectable composition of phosphatidylcholine devoid of sodium deoxycholate and manufacturing method thereof |
-
2014
- 2014-09-17 TW TW103132145A patent/TW201605852A/en unknown
- 2014-09-17 AR ARP140103454A patent/AR097683A1/en unknown
- 2014-09-19 KR KR1020167007637A patent/KR101808969B1/en active IP Right Grant
- 2014-09-19 EP EP14783708.2A patent/EP3049414A1/en not_active Withdrawn
- 2014-09-19 CN CN201480053230.2A patent/CN105579454A/en active Pending
- 2014-09-19 US US15/022,657 patent/US20160228586A1/en not_active Abandoned
- 2014-09-19 MX MX2016003725A patent/MX2016003725A/en unknown
- 2014-09-19 JP JP2016516543A patent/JP2016531851A/en not_active Withdrawn
- 2014-09-19 EA EA201690294A patent/EA028426B1/en not_active IP Right Cessation
- 2014-09-19 CA CA2920402A patent/CA2920402A1/en not_active Abandoned
- 2014-09-19 AU AU2014327076A patent/AU2014327076B2/en not_active Ceased
- 2014-09-19 WO PCT/US2014/056503 patent/WO2015047902A1/en active Application Filing
-
2016
- 2016-09-13 HK HK16110824.3A patent/HK1222654A1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013017585A1 (en) * | 2011-08-01 | 2013-02-07 | Abx Advanced Biochemical Compounds Gmbh | Precursor compounds for the radiosynthesis of [18f] norchloro-fluorohomoepibatidine |
Non-Patent Citations (6)
Title |
---|
A. CHIVATE ET AL.: "Formulation and development of oral dry suspension using taste masked Ornidazole particles prepared using Kollicoat® Smartseal 30 D", DRUG VEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 39, no. 7, July 2013 (2013-07-01), pages 1091 - 1097, XP002735121, ISSN: 1520-5762, Retrieved from the Internet <URL:http://informahealthcare.com/doi/abs/10.3109/03639045.2012.709250> [retrieved on 20150128], DOI: 10.3109/03639045.2012.709250 * |
B.G. HOCKLEY ET AL.: "(-)-[18F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 56, no. 12, 16 July 2013 (2013-07-16), pages 595 - 599, XP002731792, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3069/pdf> [retrieved on 20141029], DOI: 10.1002/jlcr.3069 * |
CHUN-FANG XIA ET AL.: "[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease", ALZHEIMER'S & DEMENTIA, vol. 9, no. 6, 16 July 2013 (2013-07-16), pages 666 - 676, XP002731790, Retrieved from the Internet <URL:http://dx.doi.org/10.1016/j.jalz.2012.11.008> [retrieved on 20141029], DOI: 10.1016/j.jalz.2012.11.008 * |
DAVID T CHIEN ET AL: "Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807", JOURNAL OF ALZHEIMER'S DISEASE, IOS PRESS, NL, vol. 34, February 2013 (2013-02-01), pages 457 - 468, XP008174041, ISSN: 1387-2877, DOI: 10.3233/JAD-122059 * |
T.M. SHOUP ET AL.: "A concise radiosynthesis of the tau radiopharmaceutical, [18F]T807", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 56, no. 14, 24 July 2013 (2013-07-24), pages 736 - 740, XP002731791, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3098/pdf> [retrieved on 20141029], DOI: 10.1002/jlcr.3098 * |
Z. UJHELYI ET AL.: "Assessment of the hemolytic activity and cyctotoxicity of different PEG-based solubilizing agents", PHARMAZIE, vol. 68, no. 5, May 2013 (2013-05-01), pages 383 - 384, XP002735122, ISSN: 0031-7144, Retrieved from the Internet <URL:http://ingentaconnect.com/content/govi/pharmaz/2013/00000068/00000005/art00014> [retrieved on 20150128], DOI: 10.1691/ph.2013.2207 * |
Also Published As
Publication number | Publication date |
---|---|
AU2014327076B2 (en) | 2016-12-22 |
KR101808969B1 (en) | 2017-12-13 |
CA2920402A1 (en) | 2015-04-02 |
US20160228586A1 (en) | 2016-08-11 |
KR20160045143A (en) | 2016-04-26 |
AR097683A1 (en) | 2016-04-06 |
MX2016003725A (en) | 2016-05-31 |
EA028426B1 (en) | 2017-11-30 |
AU2014327076A1 (en) | 2016-02-18 |
CN105579454A (en) | 2016-05-11 |
JP2016531851A (en) | 2016-10-13 |
EA201690294A1 (en) | 2016-06-30 |
HK1222654A1 (en) | 2017-07-07 |
EP3049414A1 (en) | 2016-08-03 |
TW201605852A (en) | 2016-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105358558B (en) | It is used as the diaza carbazole derivates of TAU PET parts | |
AU2014327076B2 (en) | Compounds and their use for preparation of tau imaging agents and tau imaging formulations | |
EP2365974B1 (en) | Fluorinated benzothiazole derivatives, preparation method thereof and imaging agent for diagnosing altzheimer's disease using the same | |
KR101761451B1 (en) | Method for production of f-18 labeled amyloid beta ligands | |
CN111712265B (en) | Diagnostic composition for PET imaging, method for producing the same and use thereof in diagnosis | |
Gao et al. | Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer’s disease | |
AU2019212170B2 (en) | Novel method of preparing an imaging compound | |
KR101906873B1 (en) | Method for production of f-18 labeled amyloid beta ligands | |
CA3003884C (en) | Azetidine derivatives for tau imaging | |
EA042728B1 (en) | A NEW METHOD FOR OBTAINING A VISUALIZING COMPOUND | |
BR112020014949B1 (en) | METHOD FOR PREPARING AN IMAGE FORMING COMPOUND | |
EA039208B1 (en) | Tau pet imaging ligands |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201480053230.2 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14783708 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2920402 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2014327076 Country of ref document: AU Date of ref document: 20140919 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 201690294 Country of ref document: EA |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2016/003725 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref document number: 2016516543 Country of ref document: JP Kind code of ref document: A Ref document number: 20167007637 Country of ref document: KR Kind code of ref document: A |
|
REEP | Request for entry into the european phase |
Ref document number: 2014783708 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2014783708 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112016005729 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 112016005729 Country of ref document: BR Kind code of ref document: A2 Effective date: 20160316 |