WO2015030677A3 - A method of predicting one or more neuro-developmental phenotypes of a subject - Google Patents

A method of predicting one or more neuro-developmental phenotypes of a subject Download PDF

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Publication number
WO2015030677A3
WO2015030677A3 PCT/SG2014/000404 SG2014000404W WO2015030677A3 WO 2015030677 A3 WO2015030677 A3 WO 2015030677A3 SG 2014000404 W SG2014000404 W SG 2014000404W WO 2015030677 A3 WO2015030677 A3 WO 2015030677A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
neuro
gene
predicting
developmental phenotype
Prior art date
Application number
PCT/SG2014/000404
Other languages
French (fr)
Other versions
WO2015030677A2 (en
Inventor
Karen Ann LILLYCROP
Keith Malcolm GODFREY
Joanna Dawn HOLBROOK
Original Assignee
University Of Southampton
Agency For Science Technology And Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Southampton, Agency For Science Technology And Research filed Critical University Of Southampton
Publication of WO2015030677A2 publication Critical patent/WO2015030677A2/en
Publication of WO2015030677A3 publication Critical patent/WO2015030677A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Abstract

The present application relates to a method of predicting at least one neuro-developmental phenotype of a subject, comprising detecting a degree of an epigenetic alteration of at least one gene or a regulatory element of the at least one gene in a sample of the subject, wherein the at least one gene is selected from the group consisting of DBH, KLK7, HES1, NR4A2, COMT, FAM83F, FANK1, MPP3, CMBL, C21 orf49, C11 orf61, TMEM65, IL1RN, SLC35F5, OR6N2, NFE2L2, TTC26, EYA2, TCF4, GAS2L3, ZMPSTE24, CIB4, LONRF1, KLRC4, RTN3, FGFBP3, RNF103, INHBA-AS1, CIA01, CLEC12A, SIM2, ACADSB, C9orf5, ABCA5, FER1L5, DERA, FGF11, ETS1, GAB1, CNN1, and OR1S1, and wherein the degree of the epigenetic alteration of the at least one gene or the regulatory element of the at least one gene indicates the - neuro-developmental phenotype of the subject. There is also provided a kit for performing a method of predicting at least one neuro-developmental phenotype of a subject, and a method of screening a prenatal composition for improving at least one neuro-developmental phenotype of a subject.
PCT/SG2014/000404 2013-08-27 2014-08-27 A method of predicting one or more neuro-developmental phenotypes of a subject WO2015030677A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361870443P 2013-08-27 2013-08-27
US61/870,443 2013-08-27

Publications (2)

Publication Number Publication Date
WO2015030677A2 WO2015030677A2 (en) 2015-03-05
WO2015030677A3 true WO2015030677A3 (en) 2016-08-25

Family

ID=52587458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2014/000404 WO2015030677A2 (en) 2013-08-27 2014-08-27 A method of predicting one or more neuro-developmental phenotypes of a subject

Country Status (1)

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WO (1) WO2015030677A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109735541B (en) * 2019-01-24 2020-07-03 广东海洋大学 ACADSB gene knockout dairy cow mammary gland epithelial cell line and construction method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089555A1 (en) * 2007-01-23 2008-07-31 Centre For Addiction And Mental Health Et Al Dna methylation changes associated with major psychosis
US20090104615A1 (en) * 2006-05-02 2009-04-23 Keith Malcolm Godfrey Phenotype prediction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090104615A1 (en) * 2006-05-02 2009-04-23 Keith Malcolm Godfrey Phenotype prediction
WO2008089555A1 (en) * 2007-01-23 2008-07-31 Centre For Addiction And Mental Health Et Al Dna methylation changes associated with major psychosis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ABDOLMALEKY, HM. ET AL.: "Epigenetic and genetic aberrations of the brain dopaminergic system in schizophrenia and bipolar disorder: achievements and prospective", IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES., vol. 2, 2008, pages 4 - 13 *
ABDOLMALEKY, HM. ET AL.: "Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder", HUM. MOL. GENET., vol. 15, 2006, pages 3132 - 3145 *
MILL, J. ET AL.: "Epigenomic profiling reveals DNA-methylation changes associated with major psychosis", AM. J. HUM. GENET., vol. 82, 2008, pages 696 - 711 *
URSINI, G. ET AL.: "Stress-related methylation of the catechol-O methyltransferase Val158 allele predicts human prefrontal cognition and activity", J. NEUROSCI., vol. 31, 2011, pages 6692 - 6698 *
ZHAO, X. ET AL.: "Epigenetics and neural developmental disorders", EPIGENETICS, vol. 2, 2007, pages 126 - 138 *

Also Published As

Publication number Publication date
WO2015030677A2 (en) 2015-03-05

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