WO2015028630A1 - Composés de pyridylidène n-substitués et leurs dérivés utilisables pour lutter contre les animaux nuisibles - Google Patents

Composés de pyridylidène n-substitués et leurs dérivés utilisables pour lutter contre les animaux nuisibles Download PDF

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WO2015028630A1
WO2015028630A1 PCT/EP2014/068415 EP2014068415W WO2015028630A1 WO 2015028630 A1 WO2015028630 A1 WO 2015028630A1 EP 2014068415 W EP2014068415 W EP 2014068415W WO 2015028630 A1 WO2015028630 A1 WO 2015028630A1
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het
compounds
examples
alkyl
especially preferred
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PCT/EP2014/068415
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Nina Gertrud Bandur
Martin John MCLAUGHLIN
Matthias Pohlman
Jochen Dietz
Wolfgang Von Deyn
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Basf Se
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Definitions

  • N-substituted pyndylidene compounds and derivatives for combating animal pests N-substituted pyndylidene compounds and derivatives for combating animal pests
  • the present invention relates to N-substituted pyridylidene compounds, to the enantiomers, diastereomers, derivatives and salts thereof and to compositions comprising such compounds.
  • the invention also relates to the use of the N-substituted pyridylidene compounds, of their salts or of compositions comprising them for combating animal pests. Furthermore the invention relates also to methods of applying such compounds.
  • Animal pests destroy growing and harvested crops and attack wooden dwelling and commercial structures, causing large economic loss to the food supply and to property. While a large number of pesticidal agents are known, due to the ability of target pests to develop resistance to said agents, there is an ongoing need for new agents for combating animal pests. In particular, animal pests such as insects and acaridae are difficult to be effectively controlled. It is therefore an object of the present invention to provide compounds having a good pesticidal activity, especially against difficult to control insects and acaridae.
  • A is a 6-membered saturated, partially or fully unsaturated N-heterocyclic ring; k is an integer selected from 0, 1 , 2, 3 or 4; is selected from O and S;
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and/or sulfur, optionally substituted with 1 , 2, 3 or 4, substituents R 18 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized,
  • R 1 and R 2 from, together with the carbon atom, which they attached to, a 3-, 4, 5- or 6-membered saturated or partly unsaturated carbocyclic or heterocyclic ring, wherein each of the carbon atoms of said cycle are unsubstituted or may carry any combination of 1 or 2 radicals R 7 ,
  • Het is a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated or aromatic heterocyclic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized, and wherein the Het ring may be attached by a carbon or a nitrogen bond;
  • phenyl or the Het may optionally be substituted with q substituents selected from Ry, wherein
  • q is an integer selected from 1 , 2, 3, 4 or 5;
  • Y is a single bond, CH 2 , NR 5 , O or S;
  • Ar is phenyl, naphthyl or
  • a mono- or bicyclic 5 to 10- membered heteroaromatic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • Cy is a C3-C12 cycloalkyl or C3-C12 cycloalkenyl, which is unsubstituted or substituted with 1 to 5 radicals selected independently of one another from the group consisting of hydrogen, halogen, CN, NO2, OH, SH,NH2, CO2H, Ci-C 6 alkyl, Ci-C 6 haloalkyl, Ci-C 6 alkoxy, C 2 -C 6 alkenyloxy, C 2 - C6 alkynyloxy, C1-C6 haloalkoxy and C1-C6 alkylthio;
  • R 4c2 , R 4d1 and R 4d2 are each independently from one another selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 al- kylamino, C3-C6 cycloalkyl, wherein each carbon atom of the carbon chain may be partially or fully halogenated or may be substituted with 1 , 2 or 3 radials selected independently from one another from the group consisting of CN, N0 2 , CN , OH, SH or NH 2 ;
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted with 1 , 2, 3 or 4 substituents R 10 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized,
  • two R 7 may form a 3-, 4-, 5-, 6-, 7- or 8-membered saturated or partly unsaturated carbocyclic or heterocyclic ring together with the carbon atoms to which the two R 7 are bonded to; is each independently from one another selected from the group consisting of hydrogen, cyano, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci- C6-alkoxy-Ci-C6-alkyl, Ci-C6-alkylthio, Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6- haloalkylthio, Cs-Cs-cycloalkyl, C3-Cs-cycloalkyl-Ci-C4-alkyl, Cs-Cs-halocycloalkyl, C 2 -C 6 -alkenyl, C 2
  • phenyl phenyl-Ci-C4-alkyl, wherein the phenyl moiety of the last two aforemen- tioned radicals is optionally substituted with one or more substituents R 10 ; which are selected independently from one another,
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted with 1 , 2, 3 or 4 substituents R 10 , selected inde- pendently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • R 9a , R 9b are each independently from one another selected from the group consisting of hydrogen, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio, Cs-Cs-cycloalkyl, Cs-Cs-halocycloalkyl, C 2 -
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted with 1 , 2, 3 or 4 substituents R 10 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized; or,
  • R 9a and R 9b are together a C 2 -C7 alkylene chain and form a 3-, 4-, 5-, 6-,
  • alkylene chain may contain one or two heteratoms or heteroatom groups selected from oxygen, sulfur, nitrogen, SO, S0 2 and NO, and may optionally be substituted with halogen, Ci-C6-alkyl, Ci-C6-haloalkyl, C1-C6- alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, C1-C6- haloalkylthio, Cs-Cs-cycloalkyl, Cs-Cs-halocycloalkyl, C 2 -C6- alkenyl, C 2 -C6-haloalkenyl, C 2 -C6-alkynyl, C 2 -C6 haloalkynyl, phenyl, optionally substituted with 1 , 2, 3, 4 or 5 substituents R 10 ;
  • NR 17 or NOR 16 radical; is each independently from one another selected from the group consisting of hydrogen, halogen, cyano, azido, nitro, SCN, SF 5 , Ci-Cio-alkyl, Cs-Cs-cycloalkyl, C2- Cio-alkenyl, C2-Cio-alkynyl, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 15 , which are selected independently from one another,
  • phenyl optionally substituted with halogen, cyano, nitro, Ci-C6-alkyl, C1-C6- haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy,
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted with one or more substituents selected independently from one another from halogen, cyano, NO2, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy, and wherein the nitrogen and/or the sulfur at- om(s) of the heterocyclic ring may optionally be oxidized;
  • R 12 are each independently from one another selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloal- koxyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, Ci-C6-alkoxy-Ci-C6-alkyl, Ci-C6-haloalkoxy- d-Ce-alkyl,
  • phenyl and benzyl wherein the last two aromatic radicals may optionally substituted with 1 , 2, 3, 4 or 5 substituents R 18 ; which are selected independently from one another;
  • R 15 is each independently from one another selected from the group consisting of hydrogen, cyano, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-haloalkylthio, trimethylsilyl, triethylsilyl, fer/butyldimethylsi- lyl,
  • Ci-C6-haloalkyl Ci-C6-alkoxy, C1-C6 haloalkoxy or (Ci-C6-alkoxy)carbonyl;
  • R 17a , R 17b are each independently from one another selected from the group consisting of hydrogen, cyano, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, C1-C6- alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-haloalkylthio, trimethylsilyl, triethylsilyl, ferfbutyldimethylsilyl,
  • phenyl, benzyl, pyridyl, phenoxy wherein the four last mentioned radicals may be unsubstituted, partially or fully halogenated and/or carry 1 , 2 or 3 substituents selected from Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, C1-C6 haloalkoxy or (Ci-C6-alkoxy)carbonyl,
  • R 17a and R 17b may together be a C2-C6-alkylene or -alkenylene chain forming a 3- to 7-membered saturated, partly saturated or unsaturated ring together with the nitrogen atom R 17a and R 17b are bonded to, wherein the alkylene or alkenylene chain may contain 1 or 2 heteroatoms selected from oxygen, sulfur or nitrogen, and may optionally be substituted with halogen, Ci-C4-haloalkyl,
  • Ci-C4-alkoxy or Ci-C4-haloalkoxy wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • R18 is selected, independently from one another and independently from thenumber present in the molecule, from the group consisting of hydrogen, halogen, cyano, Ci- C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Cs-Cs-cycloalkyl, wherein the four last men- tioned aliphatic radicals may be unsubstituted, partially or fully halogenated and/or oxygenated and/or may carry 1 -2 radicals selected from C1-C4 alkoxy;
  • the two adjacent R 18 s may form a 3-, 4-, 5-, 6- or 7-membered saturated, partly saturated or unsaturated ring together with the atom bearing them by forming a C2-C6 alkylene chain; in this case, the al- kylene chain may contain 1 or 2 oxygen atoms, sulfur atoms or nitrogen atoms, and may be arbitrarily substituted with halogen atoms, Ci-C4-haloalkyl, Ci-C4-alkoxy, Ci- C4-haloalkoxy;
  • R 19 is each independently from one another selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy and phenyl; n is an integer selected independently from one another from 0, 1 or 2; and an enantiomer, diastereomer, E/Z-isomer or agriculturally or veterinarily acceptable salts thereof.
  • the invention relates to pesticidal-N-substituted pyridylidene compounds of formula (I),
  • phenyl optionally substituted with one or more, e.g. 1 , 2, 3, 4 or 5 sub-stituents R 18 , which are independently selected from one another,
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and/or sulfur, optionally substituted with 1 , 2, 3 or 4, substituents R 18 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized,
  • R 1 and R 2 from, together with the carbon atom, which they attached to, a 3- to 6- membered saturated or partly unsaturated carbocyclic or heterocyclic ring, wherein each of the carbon atoms of said cycle are unsubstituted or may carry any combination of 1 or 2 radicals R 7 ,
  • Het is a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated or aromatic heterocyclic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized, and wherein the Het ring may be attached by a carbon or a nitrogen bond;
  • phenyl or the Het may optionally be substituted with q substituents selected from Ry, wherein
  • q is an integer selected from 1 , 2, 3, 4 or 5;
  • Ry is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, azido, nitro, SCN, SF 5 , Ci- Cio-alkyl, Cs-Cs-cycloalkyl, C2-Cio-alkenyl, C2-Cio-alkinyl, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 7 , which are selected independently from one another,
  • Y is a single bond, CH 2 , NR 5 , O or S;
  • Ar is phenyl, naphtyl or
  • a mono- or bicyclic 5 to 10- membered heteroaromatic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • Cy is a C3-C12 cycloalkyl, which is unsubstituted or substituted with 1 to 5 radicals selected independently of one another from the group consisting of hydrogen, halogen, CN, N0 2 , OH, SH,NH 2 , C0 2 H, Ci-C 6 alkyl, Ci-C 6 haloalkyl, C1-C6 alkoxy, C2-C6 alkenyloxy, C2-C6 alkynyloxy, C1-C6 haloalkoxy, C1-C6 alkylthio;
  • R 4c2 , R 4d1 and R 4d2 are each independently from one another selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 al- kylamino, C3-C6 cycloalkyl, wherein each carbon atom of the carbon chain may be partially or fully halogenated or may be substituted with 1 , 2 or 3 radials selected independently from one another from the group consisting of CN, N0 2 , CN, OH, SH or NH 2 ;
  • Ci-C6-alkyl Ci-C6-haloalkyl, Ci-C6-alkoxy, C1-C6 haloalkoxy or (Ci-C6-alkoxy)carbonyl; is selected each, independently from the value of k and from one another, from the group consisting of hydrogen, halogen, azido, CN , NO2, SCN , SF 5 , Ci-C6-alkyl, Cs-Cs-cycloalkyl, C2-C6-alkenyl, C2-C6-alkinyl, and wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be further substituted independently from one another with one or more R 7 ,
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and/or sulfur, optionally substituted with 1 , 2, 3 or 4 substituents R 10 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized,
  • two R 7 may form a 3-, 4-, 5-, 6-, 7- or 8-membered saturated or partly unsaturated carbocyclic or heterocyclic ring together with the carbon atoms to which the two R 7 are bonded to; is each independently from one another selected from the group consisting of hydrogen, cyano, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy,
  • R 9a , R 9b are each independently from one another selected from the group consisting of hydrogen, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio, Cs-Cs-cycloalkyl, Cs-Cs-halocycloalkyl, C2- C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkinyl, C2-C6
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxy- gen, nitrogen and/or sulfur, optionally substituted with 1 , 2, 3 or 4 substituents
  • R 10 selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized; or,
  • R 9a and R 9b are together a C2-C7 alkylene chain and form a 3-, 4-, 5-, 6-,
  • alkylene chain may contain one or two heteratoms selected from oxygen, sulfur or nitrogen, and may optionally be substituted with halogen, Ci-C6-alkyl, Ci- C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio,
  • phenyl optionally substituted with one or more substituents R 10 ; which are selected independently from one another, a 3-, 4-, 5-, 6,- or 7-membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and/or sulfur, optionally substituted with one or more substituents R 10 , selected independently from one another, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • NR 17 or NOR 16 radical; is each independently from one another selected from the group consisting of hydrogen, halogen, cyano, azido, nitro, SCN, SF 5 , Ci-Cio-alkyl, Cs-Cs-cycloalkyl, C2- Cio-alkenyl, C2-Cio-alkinyl, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 15 , which are selected independently from one another,
  • phenyl optionally substituted with halogen, cyano, nitro, Ci-C6-alkyl, C1-C6- haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy,
  • a 3-, 4-, 5-, 6- or 7- membered saturated, partly saturated or unsaturated aromatic heterocyclic ring comprising 1 , 2 or 3 heteroatoms selected from oxygen, nitrogen and/or sulfur, optionally substituted with one or more substituents selected independently from one another from halogen, cyano, NO2, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy, and wherein the nitrogen and/or the sulfur at- om(s) of the heterocyclic ring may optionally be oxidized;
  • R 11 , R 12 are each independently from one another selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloal- koxyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkinyl, C2-C6 haloalkinyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, C1-C6 alkoxyalkyl, C1-C6 haloalkoxyalkyl, Phenyl and benzyl, wherein the last two aromatic radicals may optionally substituted with one or more substituents R 18 ; which are selected independently from one another;
  • R 13 , R 14 are each independently from one another selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C6 cycloalkyl, C1-C4 alkoxyalkyl, N(CH3)2, phenyl and benzyl;
  • R 16 is each independently from one another selected from the group consisting of hy- drogen, cyano, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-alkylsulfinyl,
  • Ci-C6-alkylsulfonyl Ci-C6-haloalkylthio, trimethylsilyl, triethylsilyl, fer/butyldimethylsi- iyi.
  • Ci-C6-alkyl C2-C6-alkenyl, C2-C6-alkinyl, Cs-Cs-cycloalkyl, wherein the four last mentioned radicals may be unsubstituted, partially or fully halogenated and/or oxygenat- ed and/or may carry 1 or 2 radicals selected from Ci-C 4 alkoxy,
  • R 17a , R 17b are each independently from one another selected from the group consisting of hydrogen, cyano, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, C1-C6- alkylsulfinyl, Ci-C6-alkylsulfonyl, Ci-C6-haloalkylthio, trimethylsilyl, triethylsilyl, ferfbutyldimethylsilyl,
  • phenyl, benzyl, pyridyl, phenoxy wherein the four last mentioned radicals may be unsubstituted, partially or fully halogenated and/or carry 1 , 2 or 3 substitu- ents selected from Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, C1-C6 haloalkoxy or (Ci-C6-alkoxy)carbonyl,
  • R 17a and R 17b may together be a C2-C6-alkyl or alkylen chain forming a 3- to 7- membered saturated, partly saturated or unsaturated ring together with the ni- trogen atom R 17a and R 17b are bonded to, wherein the alkylene chain may contain 1 or 2 heteroatoms selected from oxygen, sulfur or nitrogen, and may optionally be substituted with halogen, Ci-C 4 -haloalkyl, Ci-C 4 -alkoxy or Ci-C 4 - haloalkoxy, and wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized; R 18 is selected, independently from one another and independently from thenumber present in the molecule, from the group consisting of hydrogen, halogen, cyano, Ci- C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, Cs-Cs-cycloalkyl, wherein the four last mentioned
  • Ci-C6-haloalkyl Ci-C6-alkoxy, C1-C6 haloalkoxy;
  • the two adjacent R 17 s may form a 3- to 7-membered saturated, partly saturated or unsaturated ring together with the atom bearing them by forming a C2-C6 alkylene chain; in this case, the alkylene chain may contain 1 -2 oxygen atoms, sulfur atoms or nitrogen atoms, and may be arbitrarily substituted with halogen atoms, Ci-C4-haloalkyl, Ci-C4-alkoxy, C1-C4- haloalkoxy;
  • R 19 is each independently from one another selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy and phenyl; n is an integer selected independently from one another from 0, 1 or 2; and/or an enantiomer, diastereomer, E/Z-isomer or agriculturally or veterinarily acceptable salts thereof.
  • N-substituted pyridylidene compounds of the general formula I of the present invention have not been described previously. Similar compounds are known for pharmaceutical pruposes.
  • WO 2009/048936 and WO 2010/1 1 1572 describe related acyl imino-pyridines as ligands for the Cannabinoid Receptor.
  • EP 1820504 also describes related acyl imino-pyridines as ligands for the Cannabinoid Receptor.
  • N-substituted pyridylidene compounds of the formula I and their agriculturally or veterinarily acceptable salts are highly active against animal pest, i.e. harmful arthropodes and nematodes, especially against difficult to control insects and acaridae. Accordingly, the present invention relates to N-substituted pyridylidene compounds of the general formula I, to their agriculturally or veterinarily useful salts, their enantiomers or diasterom- ers.
  • the present invention relates to and includes the following embodiments:
  • compositions comprising an amount of at least one compound of the formula I or an enantiomer, diasteromer or salt thereof;
  • a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one compound of the formula I or an enantiomer, diasteromer or salt thereof;
  • a method for protecting crops from attack or infestation by animal pests which comprises contacting a crop with a pesticidally effective amount of at least one compound of the formula I or an enantiomer, diasteromer or salt thereof;
  • a method for the protection of plant propagation, especially seeds, from soil insects and of the seedlings' roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with at least one compound of the formula I, or the enantiomers, diastereomers or salts thereof;
  • seeds comprising a compound of the formula I or an enantiomer, diasteromer or salt thereof;
  • a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of an compound of formula I or the enantiomers, diastereomers and/or veterinary acceptable salt thereof;
  • a process for the preparation of a veterinary composition for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises adding a parasiticidally effective amount of an compound of formula I or the enantiomers, diastereomers and/or veterinary acceptable salt thereof to a carrier composition suitable for veterinary use;
  • the present invention especially relates to plant propagation materials, in particular as mentioned above to seeds, comprising at least one compound of formula I and/or an agriculturally acceptable salt thereof.
  • the present invention relates to every possible stereoisomer of the compounds of formula I, i.e. to single enantiomers or diastereomers, as well as to mixtures thereof.
  • the present invention relates to each isomer alone, or mixtures or combinations of the isomers in any proportion to each other.
  • the compounds of the present invention may be amorphous or may exist in one ore more different crystalline states (polymorphs) or modifications which may have a different macroscopic properties such as stability or show different biological properties such as activities.
  • the present invention includes both amorphous and crystalline compounds of the formula I, mixtures of different crystalline states or modifications of the respective compound I, as well as amorphous or crystalline salts thereof.
  • Salts of the compounds of the formula I are preferably agriculturally and/or veterinary acceptable salts. They can be formed in a customary method, e.g. by reacting the compound with an acid of the anion in question if the compound of formula I has a basic functionality or by reacting an acidic compound of formula I with a suitable base.
  • Suitable agriculturally or veterinary useful salts are especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, do not have any adverse effect on the action of the compounds according to the present invention.
  • Suitable cations are in particular the ions of the alkali metals, preferably lithium, sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, and of the transition metals, preferably manganese, copper, zinc and iron, and also ammonium (NhV) and substituted ammonium in which one to four of the hydrogen atoms are replaced by Ci-C4-alkyl, C1-C4- hydroxyalkyl, Ci-C4-alkoxy, Ci-C4-alkoxy-Ci-C4-alkyl, hydroxy-Ci-C4-alkoxy-Ci-C4-alkyl, phenyl or benzyl.
  • substituted ammonium ions comprise methylammonium, isoprop- ylammonium, dimethylammonium, diisopropylammonium, trimethylammonium, tetrame- thylammonium, tetraethylammonium, tetrabutylammonium, 2-hydroxyethylammonium, 2-(2- hydroxyethoxy)ethyl-ammonium, bis(2-hydroxyethyl)ammonium, benzyltrimethylammonium and benzyltriethylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(Ci-C4- alkyl)sulfonium, and sulfoxonium ions, preferably tri(Ci-C4-alkyl)sulfoxonium.
  • Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, hydrogen carbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of Ci-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting the compounds of the formulae I with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.
  • partially or fully halogenated will be taken to mean that 1 or more, e.g. 1 , 2, 3, 4 or 5 or all of the hydrogen atoms of a given radical have been replaced by a halogen atom, in particular by fluorine or chlorine.
  • substituents will be taken to mean that one or more, e.g. 1 , 2, 3 etc. or all of the hydrogen atoms of a given radical have been replaced by the substituent.
  • C n -C m -alkyl refers to a branched or unbranched saturated hydrocarbon group having n to m, e.g.
  • 1 to 10 carbon atoms preferably 1 to 6 or 1 to 4 or 1 to 3 carbon atoms, for example methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1 ,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1 ,1- dimethylpropyl, 1 ,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4- methylpentyl, 1 ,1-dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3- dimethylbutyl, 3,3-dimethylbutyl, 1 -ethylbutyl, 2-ethylbut
  • Ci-C4-alkyl means for example methyl, ethyl, propyl, 1 -methylethyl, butyl, 1 -methylpropyl, 2-methylpropyl or 1 ,1 -dimethylethyl.
  • Ci-C3-alkyl means for example me- thyl, ethyl, propyl or 1 -methylethyl (isopropyl)
  • Halomethyl is methyl in which 1 , 2 or 3 of the hydrogen atoms are replaced by halo-gen atoms. Examples are bromomethyl, chloromethyl, fluoromethyl, dichloromethyl, trichloromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl and the like.
  • C n -C m -haloalkyl refers to a straight-chain or branched alkyl group having n to m carbon atoms, e.g.
  • Ci-C4-haloalkyl such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1 -chloroethyl, 1 -bromoethyl, 1 -fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroeth
  • Ci-C4-haloalkyl such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, tri
  • Ci-Cio-haloalkyl in particular comprises Ci-C2-fluoroalkyl, which is synonym with methyl or ethyl, wherein 1 , 2, 3, 4 or 5 hydrogen atoms are substituted by fluorine atoms, such as fluoromethyl, difluoromethyl, trifluoromethyl, 1 - fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl and pentafluoromethyl.
  • C n -C m -alkoxy and “C n -C m -alkylthio" refer to straight-chain or branched alkyl groups having n to m carbon atoms, e.g. 1 to 10, in particular 1 to 6 or 1 to 4 carbon atoms (as mentioned above) bonded through oxygen or sulfur linkages, respectively, at any bond in the alkyl group.
  • Ci-C4-alkoxy such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, isobutoxy and tert-butoxy
  • futher C1-C4- alkylthio such as methylthio, ethylthio, propylthio, isopropylthio, and n-butylthio.
  • C n -C m -haloalkoxy and "C n -C m -haloalkylthio” (or C n -C m -haloalkylsulfenyl, respectively) refer to straight-chain or branched alkyl groups having n to m carbon atoms, e.g.
  • Ci-C2-haloalkoxy such as chloromethoxy, bromomethoxy, dichloromethoxy, trichlorometh- oxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoro- methoxy, chlorodifluoromethoxy, 1 -chloroethoxy, 1 -bromoethoxy, 1 -fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro
  • Ci-C2-fluoroalkoxy and Ci-C2-fluoroalkylthio refer to C1-C2- fluoroalkyl which is bound to the remainder of the molecule via an oxygen atom or a sulfur atom, respectively.
  • C2-C m -alkenyl refers to a branched or unbranched unsaturated hydrocarbon group having 2 to m, e.g. 2 to 10 or 2 to 6 carbon atoms and a double bond in any position, such as ethenyl, 1 -propenyl, 2-propenyl, 1 -methyl-ethenyl, 1 -butenyl, 2-butenyl, 3- butenyl, 1 -methyl-1 -propenyl, 2-methyl-1 -propenyl, 1 -methyl-2-propenyl, 2-methyl-2-propenyl, 1 - pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1 -methyl-1 -butenyl, 2-methyl-1 -butenyl, 3-methyl- 1 -butenyl, 1 -methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1 -butenyl, 1
  • haloalkenyl as used herein, which is also expressed as “alkenyl which is partially or fully halogenated”, refers to unsaturated straight-chain or branched hydrocarbon radicals having 2 to 3 (“C 2 -C 3 -haloalkenyl"), 2 to 4 (“C 2 -C 4 -haloalkenyl"), 2 to 6 (“C 2 -C 6 -haloalkenyl”), 2 to 8 (“C 2 - C6-haloalkenyl”) or 2 to 10 (“C2-Cio-haloalkenyl”) carbon atoms and a double bond in any position (as mentioned above), where some or all of the hydrogen atoms in these groups are re- placed by halogen atoms as mentioned above, in particular fluorine, chlorine and bromine, for example chlorovinyl, chloroallyl and the like.
  • C2-C m -alkynyl refers to a branched or unbranched unsaturated hy- drocarbon group having 2 to m, e.g. 2 to 10 or 2 to 6 carbon atoms and containing one triple bond, such as ethynyl, propynyl, 1 -butynyl, 2-butynyl, and the like.
  • haloalkynyl as used herein, which is also expressed as “alkynyl which is partially or fully halogenated”, refers to unsaturated straight-chain or branched hydrocarbon radicals having 2 to 3 (“C 2 -C 3 -haloalkynyl"), 2 to 4 ("C 2 -C 4 -haloalkynyl"), 3 to 4 ("C 3 -C 4 -haloalkynyl”), 2 to 6 (“C 2 - Ce-haloalkynyl”), 2 to 8 (“C 2 -C 8 -haloalkynyl”) or 2 to 10 (“C 2 -Cio-haloalkynyl”) carbon atoms and one or two triple bonds in any position (as mentioned above), where some or all of the hydrogen atoms in these groups are replaced by halogen atoms as mentioned above, in particular fluorine, chlorine and bromine.
  • C 2 -C6-alkenyloxy relates to a C 2 -C6-alkenyl group, as defined above, bound via an oxygen atom. Examples are ethenyloxy, prop-1 -enyloxy, prop-2-enyloxy, prop-1 -en-2-yloxy and the like.
  • C 2 -C6-alkynyloxy relates to a C 2 -C6-alkynyl group, as defined above, bound via an oxygen at- om. Examples are ethynyloxy, prop-1 -ynyloxy, prop-2-ynyloxy, and the like.
  • Ci-C 4 -alkoxy-Ci-C 4 -alkyl refers to alkyl having 1 to 4 carbon atoms, e.g. like specific examples mentioned above, wherein one hydrogen atom of the alkyl radical is replaced by an Ci-C 4 -alkoxy group.
  • Ci-C6-alkoxy-Ci-C6-alkyl refers to alkyl having 1 to 6 carbon atoms, e.g. like specific examples mentioned above, wherein one hydrogen atom of the alkyl radical is replaced by an Ci-C6-alkoxy group.
  • Examples are methoxymethyl, ethox- ymethyl, propoxymethyl, isopropoxymethyl, n-butoxymethyl, sec-butoxymethyl, isobutoxymethyl, tert-butoxymethyl, 1 -methoxyethyl, 1 -ethoxyethyl, 1 -propoxyethyl, 1 -isopropoxyethyl, 1 -n- butoxyethyl, 1 -sec-butoxyethyl, 1 -isobutoxyethyl, 1 -tert-butoxyethyl, 2-methoxyethyl, 2- ethoxyethyl, 2-propoxyethyl, 2-isopropoxyethyl, 2-n-butoxyethyl, 2-sec-butoxyethyl, 2- isobutoxyethyl, 2-tert-butoxyethyl, 1 -methoxypropyl, 1 -ethoxypropyl, 1 -propoxypropyl,
  • Ci-C4-alkoxy-Ci-C4-alkoxy refers to alkoxy having 1 to 4 carbon atoms, e.g. like specific examples mentioned above, wherein one hydrogen atom of the alkyl radical is replaced by an Ci-C4-alkoxy group.
  • Examples are methoxymethoxy, ethoxymethoxy, propoxymethoxy, isopropoxymethoxy, n-butoxymethoxy, sec-butoxymethoxy, isobutoxymeth- oxy, tert-butoxymethoxy, 1 -methoxyethoxy, 1 -ethoxyethoxy, 1 -propoxyethoxy, 1 - isopropoxyethoxy, 1 -n-butoxyethoxy, 1 -sec-butoxyethoxy, 1 -isobutoxyethoxy, 1 -tert- butoxyethoxy, 2-methoxyethoxy, 2-ethoxyethoxy, 2-propoxyethoxy, 2-isopropoxyethoxy, 2-n- butoxyethoxy, 2-sec-butoxyethoxy, 2-isobutoxyethoxy, 2-tert-butoxyethoxy, 1 -methoxypropoxy,
  • C3-C m -cycloalkyl refers to a monocyclic 3- to m-membered saturated cycloaliphatic radicals, in particular to a 3- to 12- ("C3-Ci2-cycloalkyl") or 3- to 8- ("C3-C8- cycloalkyl") or 3- to 7- (“C 3 -C 7 -cycloalkyl") or 3- to 6- (“C 3 -C 6 -cycloalkyl”) or 3- to 5- (“C3-C5- cycloalkyl”) or 3- to 4- (“C3-C4-cycloalkyl”) membered saturated cycloaliphatic radical.
  • Examples of monocyclic radicals having 3 to 4 carbon atoms comprise cyclopropyl and cyclobutyl.
  • Examples of monocyclic radicals having 3 to 5 carbon atoms comprise cyclopropyl, cyclobutyl and cyclopentyl.
  • Examples of monocyclic radicals having 3 to 6 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
  • Examples of monocyclic radicals having 3 to 7 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.
  • Examples of monocyclic radicals having 3 to 8 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
  • Examples of monocyclic radicals having 3 to 12 carbon atoms comprise cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cy- clononyl, cyclodecyl, cycloundecyl and cyclododecyl.
  • halocycloalkyl as used herein, which is also expressed as “cycloalkyl which is partially or fully halogenated”, refers to monocyclic saturated hydrocarbon groups having 3 to 8 (“Cs-Cs-halocycloalkyl” ) or preferably 3 to 6 (“C 3 -C 6 -halocycloalkyl") or 3 to 5 (“C3-C5- halocycloalkyl”) or 3 to 4 (“C3-C4-halocycloalkyl”) carbon ring members (as mentioned above) in which some or all of the hydrogen atoms are replaced by halogen atoms as mentioned above, in particular fluorine, chlorine and bromine.
  • Cs-Cs-halocycloalkyl monocyclic saturated hydrocarbon groups having 3 to 8 (“Cs-Cs-halocycloalkyl” ) or preferably 3 to 6 (“C 3 -C 6 -halocycloalkyl”) or 3 to 5 (“C3-C5- halocyclo
  • cycloalkyl-Ci-C4-alkyl refers to a Cs-Cs-cycloalkyl group ("C3-C8-cycloalkyl-Ci-C4- alkyl”), preferably a C3-C6-cycloalkyl group ("C3-C6-cycloalkyl-Ci-C4-alkyl”), more preferably a C3-C4-cycloalkyl group (“C3-C4-cycloalkyl-Ci-C4-alkyl”) as defined above (preferably a monocyclic cycloalkyl group) which is bound to the remainder of the molecule via a Ci-C4-alkyl group, as defined above.
  • Examples for C3-C4-cycloalkyl-Ci-C4-alkyl are cyclopropylmethyl, cyclopro- pyl ethyl, cyclopropylpropyl, cydobutylmethyl, cyclobutylethyl and cyclobutylpropyl,
  • Examples for C3-C6-cycloalkyl-Ci-C4-alkyl, apart those mentioned for C3-C4-cycloalkyl-Ci-C4-alkyl, are cyclo- pentylmethyl, cyclopentylethyl, cyclopentylpropyl, cyclohexylmethyl, cyclohexylethyl and cyclo- hexylpropyl.
  • C3-C8-halocycloalkyl-Ci-C4-alkyl refers to a Cs-Cs-halocycloalkyl group as defined above which is bound to the remainder of the molecule via a Ci-C4-alkyl group, as defined above.
  • cycloalkenyl refers to monocyclic hydrocarbon radicals with at least one C-C double bond in the ring, which ring is however not aromatic, the hydrocarbon radicals having 3 to 12 ("C 3 -Ci 2 -cycloalkenyl) or 3 to 8 (“C 3 -C 8 -cycloalkenyl) or 3 to 7 (“C3-C7- cycloalkenyl) carbon atoms.
  • Examples are cyclopropenyl, such as cycloprop-1 -enyl and cyclo- prop-2-yl, cyclobutenyl, such as cyclobut-1 -enyl and cyclobut-2-enyl, cyclopentenyl, such as cyclopent-1 -enyl, cyclopent-2-enyl and cyclopent-3-enyl, cyclopentadienyl, such as cyclopenta- 1 ,3-dienyl, cyclpenta-1 ,4-dienyl and cyclpenta-2,4-dienyl, cyclohexenyl, such as cyclohex-1 - enyl, cyclohex-2-enyl and cyclohex-3-enyl, cyclohexadienyl, such as cyclohexa-1 ,3-dienyl, cyclohexa-1 ,4-dienyl, cycl
  • halocycloalkenyl refers to monocyclic hydrocarbon radicals with at least one C-C double bond in the ring, which ring is however not aromatic, the hydrocarbon radicals having 3 to 8 (“Cs-Cs-halocycloalkyl”) carbon atoms, and wherein some or all of the hydro- gen atoms are replaced by halogen atoms as mentioned above, in particular fluorine, chlorine and bromine.
  • C3-C6-Cycloalkoxy is a C3-C6-cycloalkyl group, as defined above, bound via an oxygen atom. Examples are cyclopropoxy, cyclobutoxy, cyclopentoxy and cyclohexoxy.
  • Phenyl-Ci-C4-alkyl is a Ci-C4-alkyl group, as defined above, in which a hydrogen atom is replaced by a phenyl group. Examples are benzyl, 1-phenylethyl and phenethyl.
  • Phenyl-Ci-C4-alkoxy is a Ci-C4-alkoxy group, as defined above, in which a hydrogen atom is replaced by a phenyl group. Examples are benzyloxy, 1 -phenylethoxy and 2-phenylethoxy.
  • C i -C2-a I ky Is u If i nyl is a Ci-C2-alkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-C4-alkylsulfinyl is a Ci-C4-alkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • C i -C6-a I ky Is u If i nyl" is a Ci-C6-alkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-Cio-alkylsulfinyl is a Ci-Cio-alkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-C2-Alkylsulfinyl is methylsulfinyl or ethylsulfinyl.
  • Ci-C4-Alkylsulfinyl is additionally, for example, n-propylsulfinyl, 1 - methylethylsulfinyl (isopropylsulfinyl), butylsulfinyl, 1 -methylpropylsulfinyl (sec-butylsulfinyl), 2- methylpropylsulfinyl (isobutylsulfinyl) or 1 ,1 -dimethylethylsulfinyl (tert-butylsulfinyl).
  • C1-C6- Alkylsulfinyl is additionally, for example, pentylsulfinyl, 1 -methylbutylsulfinyl,
  • d-Cs-Alkylsulfinyl is additionally, for example, heptylsulfinyl, octylsulfinyl, 2-ethylhexylsulfinyl and positional isomers thereof.
  • Ci-Cio-Alkylsulfinyl is additionally, for example, nonylsulfinyl, decylsulfinyl and positional isomers thereof.
  • Ci-C2-haloalkylsulfinyl is a Ci-C2-haloalkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-C4-haloalkylsulfinyl is a Ci-C4-haloalkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-C6-haloalkylsulfinyl is a C1-C6- haloalkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • C1-C10- haloalkylsulfinyl is a Ci-Cio-haloalkyl group, as defined above, attached via a sulfinyl [S(O)] group.
  • Ci-C 2 -Haloalkylsulfinyl is, for example, S(0)CH 2 F, S(0)CHF 2 , S(0)CF 3 , S(0)CH 2 CI, S(0)CHCl2, S(0)CCl3, chlorofluoromethylsulfinyl, dichlorofluoromethylsulfinyl, chlorodifluorome- thylsulfinyl, 2-fluoroethylsulfinyl, 2-chloroethylsulfinyl, 2-bromoethylsulfinyl, 2-iodoethylsulfinyl, 2,2-difluoroethylsulfinyl, 2,2,2-trifluoroeth
  • Ci- C4-Haloalkylsulfinyl is additionally, for example, 2-fluoropropylsulfinyl, 3-fluoropropylsulfinyl, 2,2- difluoropropylsulfinyl, 2,3-difluoropropylsulfinyl, 2-chloropropylsulfinyl, 3-chloropropylsulfinyl, 2,3-dichloropropylsulfinyl, 2-bromopropylsulfinyl, 3-bromopropylsulfinyl, 3,3,3- trifluoropropylsulfinyl, 3,3,3-trichloropropylsulfinyl, S(0)CH 2 -C 2 F 5 , S(0)CF 2 -C 2 F 5 , 1 -(CH 2 F)-2- fluoroethylsulfinyl, 1 -(CH 2 CI)-2-ch
  • C1-C6- Haloalkylsulfinyl is additionally, for example, 5-fluoropentylsulfinyl, 5-chloropentylsulfinyl, 5- brompentylsulfinyl, 5-iodopentylsulfinyl, undecafluoropentylsulfinyl, 6-fluorohexylsulfinyl, 6- chlorohexylsulfinyl, 6-bromohexylsulfinyl, 6-iodohexylsulfinyl or dodecafluorohexylsulfinyl.
  • Ci-C 2 -alkylsulfonyl is a Ci-C 2 -alkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C3-alkylsulfonyl is a Ci-C3-alkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C4-alkylsulfonyl is a Ci-C4-alkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C6-alkylsulfonyl is a Ci-C6-alkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-Cio-alkylsulfonyl is a Ci-Cio-alkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C 2 -Alkylsulfonyl is methylsulfonyl or ethylsulfonyl.
  • Ci-C3-Alkylsulfonyl is additionally, for example, n- propylsulfonyl or 1 -methylethylsulfonyl (isopropylsulfonyl).
  • Ci-C4-Alkylsulfonyl is additionally, for example, butylsulfonyl, 1 -methylpropylsulfonyl (sec-butylsulfonyl), 2-methylpropylsulfonyl (isobu- tylsulfonyl) or 1 ,1 -dimethylethylsulfonyl (tert-butylsulfonyl).
  • Ci-C6-Alkylsulfonyl is additionally, for example, pentylsulfonyl, 1 -methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1 ,1 - dimethylpropylsulfonyl, 1 ,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1 - ethylpropylsulfonyl, hexylsulfonyl, 1 -methylpentylsulfonyl, 2-methylpentylsulfonyl,
  • d-Cs-Alkylsulfonyl is additionally, for example, heptylsulfonyl, oc- tylsulfonyl, 2-ethylhexylsulfonyl and positional isomers thereof.
  • Ci-Cio-Alkylsulfonyl is additionally, for example, nonylsulfonyl, decylsulfonyl and positional isomers thereof.
  • Ci-C 2 -haloalkylsulfonyl is a Ci-C 2 -haloalkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C3-haloalkylsulfonyl is a Ci-C3-haloalkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-C4-haloalkylsulfonyl is a C1-C4- haloalkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • C1-C6- haloalkylsulfonyl is a Ci-C6-haloalkyl group, as defined above, attached via a sulfonyl [S(0) 2 ] group.
  • Ci-Cio-haloalkylsulfonyl is a Ci-Cio-haloalkyl group, as defined above, at- tached via a sulfonyl [S(0)2] group.
  • Ci-C2-Haloalkylsulfonyl is, for example, S(0)2CH2F, S(0) 2 CHF 2 , S(0) 2 CF 3 , S(0) 2 CH 2 CI, S(0) 2 CHCI 2 , S(0) 2 CCI 3 , chlorofluoromethylsulfonyl, dichlor- ofluoromethylsulfonyl, chlorodifluoromethylsulfonyl, 2-fluoroethylsulfonyl, 2-chloroethylsulfonyl, 2-bromoethylsulfonyl, 2-iodoethylsulfonyl, 2,2-difluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, 2- chloro-2-fluoroethylsulfonyl, 2-chloro-2,2-difluoroethylsulfonyl, 2,2-d
  • Ci-C3-Haloalkylsulfonyl is additionally, for example, 2-fluoropropylsulfonyl, 3-fluoropropylsulfonyl, 2,2-difluoropropylsulfonyl, 2,3- difluoropropylsulfonyl, 2-chloropropylsulfonyl, 3-chloropropylsulfonyl, 2,3-dichloropropylsulfonyl, 2-bromopropylsulfonyl, 3-bromopropylsulfonyl, 3,3,3-trifluoropropylsulfonyl, 3,3,3- trichloropropylsulfonyl, S(0) 2 CH2-C2F 5 , S(0)2CF2-C 2 F 5 , 1 -(CH 2 F)-2-fluoroethylsulfonyl, 1 -
  • Ci-C4-Haloalkylsulfonyl is additionally, for example, 4-fluorobutylsulfonyl, 4-chlorobutylsulfonyl, 4-bromobutylsulfonyl or no- nafluorobutylsulfonyl.
  • Ci-C6-Haloalkylsulfonyl is additionally, for example, 5-fluoropentylsulfonyl, 5-chloropentylsulfonyl, 5-brompentylsulfonyl, 5-iodopentylsulfonyl, undecafluoropentylsulfonyl, 6-fluorohexylsulfonyl, 6-chlorohexylsulfonyl, 6-bromohexylsulfonyl, 6-iodohexylsulfonyl or dode- cafluorohexylsulfonyl.
  • Examples are acetyl (methylcarbonyl), propionyl (ethylcarbonyl), propylcarbonyl, isopropylcarbonyl, n- butylcarbonyl and the like.
  • haloalkylcarbonyl is a Ci-C6-haloalkyl ("Ci-C6-haloalkylcarbonyl”), preferably a Ci- C 4 -haloalkyl (“Ci-C 4 -haloalkylcarbonyl”) group, as defined above, attached via a carbonyl
  • methoxycarbonyl methoxycarbonyl
  • ethoxycarbonyl propoxycarbonyl
  • isopropoxycarbonyl n- butoxycarbonyl and the like.
  • Ci-C6-alkylamino is a group -N(H)Ci-C6-alkyl. Examples are methylamino, ethyla- mino, propylamino, isopropylamino, butylamino and the like.
  • di-(Ci-C6-alkyl)amino is a group -N(Ci-C6-alkyl)2. Examples are dimethylamino, di- ethylamino, ethylmethylamino, dipropylamino, diisopropylamino, methylpropylamino, methyli- sopropylamino, ethylpropylamino, ethylisopropylamino, dibutylamino and the like.
  • aminocarbonyl is a group -C(0)-NH2.
  • Ci-C6-alkylaminocarbonyl is a group -C(0)-N(H)Ci-C6-alkyl. Examples are methyla- minocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, butyla- minocarbonyl and the like.
  • di-(Ci-C6-alkyl)-aminocarbonyl is a group -C(0)-N(Ci-C6-alkyl)2.
  • dime- thylaminocarbonyl diethylaminocarbonyl, ethylmethylaminocarbonyl, dipropylaminocarbonyl, diisopropylaminocarbonyl, methylpropylaminocarbonyl, methylisopropylaminocarbonyl, ethylpropylaminocarbonyl, ethylisopropylaminocarbonyl, dibutylaminocarbonyl and the like.
  • Ci-C6-alkylaminosulfonyl is a Ci-C6-alkylamino group as mentioned above, which is bound to the remainder of the molecule by a sulfonyl group.
  • di-(Ci-C6-alkyl)-aminosulfonyl is a di-(Ci-C6-alkyl)-amino group as mentioned above, which is bound to the remainder of the molecule by a sulfonyl group.
  • Ci-C6-alkylaminosulfenyl is a (Ci-C6-alkyl)amino group as mentioned above, which is bound to the remainder of the molecule by a sulfenyl group.
  • di-(Ci-C6-alkyl)-aminosulfenyl is a di-(Ci-C6-alkyl)-amino group as mentioned above, which is bound to the remainder of the molecule by a sulfenyl group.
  • Ci-C6-alkylaminosulfinyl is a (Ci-C6-alkyl)amino group as mentioned above, which is bound to the remainder of the molecule by a sulfinyl group.
  • di-(Ci-C6-alkyl)-aminosulfinyl is a di-(Ci-C6-alkyl)-amino group as mentioned above, which is bound to the remainder of the molecule by a sulfinyl group.
  • aryl refers to an aromatic hydrocarbon radical such as naphthyl or in particular phenyl.
  • 3- to 6-membered carbocyclic ring refers to cyclopropane, cyclobu- tane, cyclopentane and cyclohexane rings.
  • heterocyclic ring containing 1 , 2 or 3 heteroatoms or “containing heteroatom groups", wherein those het- eroatom(s) (group(s)) are selected from N, O, S, NO, SO and SO2 and are ring members, as used herein refers to monocyclic radicals, the monocyclic radicals being saturated, partially unsaturated or aromatic.
  • the heterocyclic radical may be attached to the remainder of the molecule via a carbon ring member or via a nitrogen ring member.
  • Examples of 3-, 4-, 5-, 6- or 7-membered saturated heterocyclyl or heterocyclic rings include: Oxiranyl, aziridinyl, azetidinyl, 2 tetrahydrofuranyl, 3-tetrahydrofuranyl, 2 tetrahydrothienyl, 3 tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3 pyrazolidinyl, 4 pyrazolidinyl, 5-pyrazolidinyl, 2 imidazolidinyl, 4 imidazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5 oxazolidinyl, 3-isoxazolidinyl, 4 isoxazolidinyl, 5 isoxazolidinyl, 2 thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 3 isothiazolidinyl, 4- isothiazolidiny
  • Examples of 3-, 4-, 5-, 6- or 7-membered partially unsaturated heterocyclyl or heterocyclic rings include: 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl, 2,3- dihydrothien-2-yl, 2,3 dihydrothien-3-yl, 2,4 dihydrothien-2-yl, 2,4-dihydrothien-3-yl, 2-pyrrolin-2- yl, 2-pyrrolin-3-yl, 3 pyrrolin-2-yl, 3-pyrrolin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4 isoxazolin 3 yl, 2-isoxazolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2 isoxazolin-5-yl
  • Examples of 5- or 6-membered aromatic heterocyclyl (hetaryl) or heteroaromatic rings are: 2- furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl, 3-pyrazolyl, 4-pyrazo-"lyl, 5-pyrazolyl, 2- oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4 thiazolyl, 5-thiazo-"lyl, 2-imidazolyl, 4-imidazolyl, 1 ,3,4-triazol-2-yl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4- pyrimidinyl, 5-pyrimidinyl and 2-pyrazinyl.
  • C2-Cm-alkylene is divalent branched or preferably unbranched saturated aliphatic chain having 2 to m, e.g. 2 to 7 carbon atoms, for example CH 2 CH 2 , -CH(CH 3 )-, CH2CH2CH2,
  • C2-Cm-alkenylene is divalent branched or preferably unbranched mono-, di- or polyunsaturated aliphatic chain having 2 to m, e.g.
  • Embodiments and Preferences Embodiments and preferred compounds of the present invention are outlined in the following paragraphs. The remarks made below concerning preferred embodiments of the variables of the compounds of formula I, especially with respect to ring A and the substituents X, R 1 ,R 2 , R 3 , R 4a , R 4b , R 4c , R 4d and R 6 are valid both on their own and, in particular, in every possible combination with each other.
  • One embodiment of the present invention are compounds of formula (I), wherein X is selected from O.
  • Another embodiment of the present invention are compounds of formula (I), wherein X is selected from S.
  • R 1 and R 2 are independently from each other selected from the group consisting of hydrogen, halogen, CN, Ci-C6-alkyl, C3-C6-cycloalkyl, Ci- C6-haloalkyl, C3-C6-halocycloalkyl; or
  • R 1 and R 2 form, together with the carbon atom, which they attached to, a 3- to 5 membered saturated carbocyclic ring;
  • R 1 and R 2 are independently from each other selected from the group consisting of hydrogen, halogen, cyano, Ci-C3-alkyl or Ci- C3-haloalkyl.
  • R 1 and R 2 are independently from each other selected from hydrogen or CH3.
  • One embodiment of the present invention are compounds of formula (l),wherein R 1 and R 2 are both hydrogen.
  • Another embodiment of the present invention are compounds of formula (l),wherein one of R 1 and R 2 is hydrogen, and the other is methyl.
  • One embodiment of the present invention are compounds of formula (I), wherein one of R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is methyl and the others are hydrogen.
  • Another embodiment of the present invention are compounds of formula (I), wherein all of R 4a , R 4b , R 4b2 , R 4c , R 4c2 , R 4d and R 4d2 are hydrogen.
  • One embodiment of the present invention are compounds of formula (I), wherein the N- heterocyclic ring A is selected from one of the followings structures A-1 to A-4:
  • #1 and #2 denotes the bonds to the remainder of the molecule, and k is an integer selected from 0 or 1 ;
  • N-heterocyclic ring A is selected from one of the structures A-1 to A-4 described above, k is an integer selected from 0 or 1 and R 6 is selected from halogen, CN, C1-C4 alkyl and Ci-C4-haloalky.
  • N-heterocyclic ring A is of the structure A-1 described above and k is an integer selected from 0, thus the N-heterocyclic ring A is unsubstituted.
  • R y is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, azido, nitro, SCN, Ci-C6-alkyl, Cs-Cs-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 7 , which are selected independently from one another,
  • Y is a single bond, CH2, O or S; is phenyl, naphthyl or
  • a monocyclic 5- or 6- membered heteroaromatic ring comprising 1 , 2, 3 or 4 het- eroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • Ar is optionally substituted with 1 , 2, 3, 4 or 5 substituents selected independently from one another from hydrogen, halogen, CN, NO2, OH, SH, N H2, CO2H , C1 -C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or Ci-C6-alkoxy, and wherein the carbon atoms of the aforementioned aliphatic radicals may be partially or fully halogenated; and
  • Cy is a C3-C7 cycloalkyl and C3-C7-cycloalkenyl, which is unsubstituted or substituted with 1 to 5 radicals selected independently of one another from the group consisting of hydrogen, halogen, CN, NO2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy,
  • two Ry on adjacent carbon atoms of the heterocyclic ring Het may form a bridge selected from CH2CH2CH2 and CH2CH2CH2CH2.
  • Ry is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, azido, nitro, SCN, Ci-C6-alkyl, Cs-Cs-cycloalkyl, C2-C6-alkenyl, C2-C6-alkinyl, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 7 , which are selected independently from one another,
  • Y is a single bond, CH2, O or S;
  • Ar is phenyl, naphtyl or
  • a mono- or bicyclic 5- or 6- membered heteroaromatic ring comprising 1 , 2, 3 or 4 heteroatoms selected from oxygen, nitrogen and/or sulfur, wherein the nitrogen and/or the sulfur atom(s) of the heterocyclic ring may optionally be oxidized;
  • Ar is optionally substituted with 1 , 2, 3, 4 or 5 substituents selected independently from one another from hydrogen, halogen, CN, NO2, OH, SH, N H2, CO2H , Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or Ci-C6-alkoxy, and wherein the carbon atoms of the aforementioned aliphatic radicals may be partially or fully halogenated; and
  • Cy is a C3-C7 cycloalkyl, which is unsubstituted or substituted with 1 to 5 radicals selected independently of one another from the group consisting of hydrogen, halogen, CN, N0 2 , Ci-C 6 alkyl, Ci-C 6 haloalkyl, Ci-C 6 alkoxy, Ci-C 6 haloal- koxy,
  • Het is selected from the group consisting of radicals of the following formulae Het-1 , Het-2, Het-
  • R y is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, nitro, SCN, Ci-C6-alkyl, Ci-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, Ci-C6-haloalkenyl, C2-C6-alkynyl, C2- C6-haloalkynyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, wherein the carbon atoms of the aforementioned aliphatic and cyclo-aliphatic radicals may optionally be substituted with one or more R 15 , which are selected independently from one another,OR 16 , -S(0) n R 16 ,
  • Y is a single bond, CH2, O or S;
  • Ar is phenyl, naphthyl or is
  • a mono- or bicyclic 5- or 6- membered heteroaromatic ring comprising 1 or 2 het- eroatoms selected from oxygen, nitrogen and/or sulfur;
  • Ar is optionally substituted with 1 , 2, or 3 substituents selected inde- pendently from one another from hydrogen, halogen, CN, NO2, OH, Ci-C6-alkyl, C2-
  • Cy is selected from the group conisiting of cyclopropane or cyclobutane, cyclo- pentane, cyclohexane and cyclohexene, wherein the aliphatic ring is unsubstituted or partly or fully halogenated;
  • two Ry on adjacent carbon atoms of the heterocyclic ring Het may form a bridge selected from CH2CH2CH2 and CH2CH2CH2CH2.
  • Y is a single bond, CH2, O or S;
  • Ar is phenyl, naphtyl or is
  • a monocyclic 5- or 6- membered heteroaromatic ring comprising 1 or 2 heteroatoms selected from oxygen, nitrogen and/or sulfur;
  • Ar is optionally substituted with 1 , 2, or 3 substituents selected independently from one another from hydrogen, halogen, CN, NO2, OH, Ci-C6-alkyl, C2- C6-alkenyl, C2-C6-alkynyl or Ci-C6-alkoxy, and wherein the carbon atoms of the aforementioned aliphatic radicals may be partially or fully halogenated; and
  • Cy is selected from the group conisiting of cyclopropane or cyclobutan, cyclopen- tan and cyclohexan, wherein the aliphatic ring is unsubstituted or partly or fully halo- genated;
  • Het is selected from the group consisting of radicals of the following formulae Het-2, Het-3, Het- 6, Het-36, Het-37 and Het-39:
  • Ry is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, Ci-C6-alkyl, Ci-C6-haloalkyl, C3-C6-cycloalkyl, C3- C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, Ci- C6-alkoxy, Ci-C6-haloalkoxy, Ci-C4-alkoxy-Ci-C4-alkoxy, phenyl-Ci-C4-alkoxy, where the phenyl ring may carry 1 , 2 or 3 substituents selected from halogen, cyano, Ci-C4-alkyl, Ci- C4-haloalkyl, Ci-C4-alkoxy and Ci-C4-haloalkoxy; Ci-C6-alkyl
  • Y is a single bond or CH2 or O
  • Ar is phenyl or a monocyclic 5- or 6- membered heteroaromatic ring selected from the group consisting of thiazoles, isothiazoles, oxazoles, isoazoles, and pyrazoles, wherein the aromatic or heteroaromatic ring is optionally substituted with 1 , 2 or 3 substituents selected independently from one another from halogen, CN, OH, Ci-C6-alkyl and C1-C6- alkoxy, and wherein the carbon atoms of the aforementioned aliphatic radicals may be partially or fully halogenated;
  • Cy is cyclopropane, cyclobutane or cyclohexene, which is unsubstituted or partly or fully halogenated; or
  • two Ry on adjacent carbon atoms of the heterocyclic ring Het may form a bridge selected from CH2CH2CH2 and CH2CH2CH2CH2.
  • Het rings of formulae Het-2, Het-3, Het-6, Het-36, Het-37 and Het-39 preference is given to Het-2 and Het-36 and especially to Het-2.
  • Ry is selected each independently from one another and from the value of q from the group consisting of hydrogen, halogen, cyano, Ci-C6-alkyl, Ci-C6-haloalkyl, C3-C6-cycloalkyl, C3- C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, Ci- C6-alkoxy, Ci-C6-haloalkoxy, Ci-C4-alkoxy-Ci-C4-alkoxy, phenyl-Ci-C4-alkoxy, where the phenyl ring may carry 1 , 2 or 3 substituents selected from halogen, cyano, Ci-C4-alkyl, Ci- C4-haloalkyl, Ci-C4-alkoxy and Ci-C4-haloalkoxy; Ci-C6-alkyl
  • Y is a single bond or CH2 or O
  • Ar is phenyl or a monocyclic 5- or 6- membered heteroaromatic ring selected from the group consisting of thiazoles, isothiazoles, oxazoles, isoazoles, and pyrazoles, wherein the aromatic or heteroaromatic ring is optionally substituted with 1 , 2 or 3 substituents selected independently from one another from halogen, CN, OH, Ci-C6-alkyl and C1-C6- alkoxy, and wherein the carbon atoms of the aforementioned aliphatic radicals may be partially or fully halogenated;
  • Cy is cyclopropane, cyclobutane or cyclohexene, which is unsubstituted or partly or fully halogenated; or
  • two Ry on adjacent carbon atoms of the heterocyclic ring Het may form a bridge selected from CH2CH2CH2 and CH2CH2CH2CH2.
  • q is 0; i.e. the isoxazoline ring is unsubstituted.
  • the isoxazoline ring Het-23 is bound via its 3-position to the remainder of the molecule.
  • R 3 is Het, and Het is selected from Het-2, Het-23 and Het-36, and is very specifcally Het-2.
  • q and R have one of the above preferred meanings.
  • One embodiment of the invention are compounds of formula (I), wherein
  • A is fully unsaturated ring
  • R 6a is each independently from one another selected from the group consisting of hydrogen, halogen, CN , C1-C4 alkyl, Ci-C4-alkoxy, Ci-C4-haloalkoxy and Ci-C4-haloalky, where at least one R 6a is hydrogen;
  • X is selected from O and S;
  • R 1 , R 2 are independently from each other selected from the group consisting of hydrogen, halogen, cyano, Ci-C3-alkyl, and Ci-C3-haloalkyl;
  • R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is each hydrogen, and R 3 is defined as above.
  • One preferred embodiment of the present invention are compounds of formula (I), wherein
  • A is fully unsaturated ring A-1
  • R 6a is each independently from one another selected from the group consisting of hydrogen, halogen, CN, C1-C4 alkyl, Ci-C4-alkoxy, Ci-C4-haloalkoxy and Ci-C4-haloalky, where at least one R 6a is hydrogen;
  • X is selected from O and S;
  • R 1 , R 2 are independently from each other selected from the group consisting of hydrogen, halogen, cyano, Ci-C3-alkyl, and Ci-C3-haloalkyl;
  • R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is each hydrogen
  • R 3 is defined according to the preferred embodiments described herein above.
  • One especially preferred embodiment of the present invention are compounds of formula (I), wherein
  • A is fully unsaturated ring A-1
  • R 6a is each independently from one another selected from the group consisting of hydrogen, halogen, CN, C1-C4 alkyl, Ci-C4-alkoxy, Ci-C4-haloalkoxy and Ci-C4-haloalky, where at least one R 6a is hydrogen;
  • X is selected from O or S;
  • R 1 , R 2 are independently from each other selected from the group consisting of hydrogen, halogen, cyano, Ci-C3-alkyl, and Ci-C3-haloalkyl;
  • R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is each hydrogen, and wherein
  • R 3 is defined according to the especially preferred embodiments described herein above.
  • One especially more preferred embodiment of the present invention are compounds of formula (I), wherein
  • A is fully unsaturated ring
  • R 6a is each independently from one another selected from the group consisting of hydrogen, halogen, CN, C1-C4 alkyl, Ci-C4-alkoxy, Ci-C4-haloalkoxy and Ci-C4-haloalky, where at least one R 6a is hydrogen;
  • X is selected from O or S
  • R 1 , R 2 are independently from each other selected from the group consisting of hydrogen, halogen, cyano, Ci-C3-alkyl, and Ci-C3-haloalkyl;
  • R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is each hydrogen
  • R 3 is defined according to the more especially preferred embodiments described herein above.
  • One embodiment of the present invention are compounds of formula II)
  • X is selected from O or S; R 1 , R 2 are both hydrogen, or
  • R 1 or R 2 is methyl and the other is hydrogen
  • R 4a , R 4b1 , R 4b2 , R 4c1 , R 4c2 , R 4d1 and R 4d2 is each hydrogen;
  • R 3 is defined as herein above.
  • R 3 is defined according to the preferred embodiments described herein above. Especially preferred are compounds are compounds of formula (II), wherein
  • R 3 is defined according to the especially preferred embodiments described herein above.
  • R 3 is defined according to the especially more preferred embodiments described herein above.
  • R 3 is selected from pyrazin-2-yl, 5-chloropyrazin-2-yl, 6-chloropyrazin-2-yl, pyridazin-4-yl, 5- phenylpyrazin-2-yl, isoxazol-3-yl, 5-(2-fluorophenoxy)pyrazin-2-yl, 5-(2,2-difluoroethoxy)pyrazin- 2-yl, 5-methoxypyrazin-2-yl, 6-methoxypyrazin-2-yl, 5-[(2,6-dichlorophenyl)methoxy]pyrazin-2-yl 6-(m-tolyl)pyrazin-2-yl, 5-[3-(trifluoromethyl)phenoxy]pyrazin-2-yl, 5-isobutoxypyrazin-2-yl 6-(2,2,2-trifluoroethoxy)pyrazin-2-yl, 5-propoxypyrazin-2-yl, 6-(2-fluorophenyl)pyrazin
  • Het-36.16 Het-36.17 Het-36.18 Het-36.19 Het-36.20
  • Het-36.26 Het-36.27 Het-36.28 Het-36.29d Het-36.30
  • Het-40.1 5-isobutoxypyrazin-2-yl
  • Het-40.24 5-methyl-2-oxo-1 H-pyrazin-3-yl
  • Het-40.17 5-(2-methoxyethoxy)pyrazin-2-yl
  • Het-40.30 5-propylpyrazin-2-yl
  • the structures I.A-1 to I.A-13 are preferably substituted according to the scheme of table C herein above, and the respective R 3 is selected from the individualized Het-structures of the tables H2, H3, H6, H36, H37,H39 and H40 further above.
  • Examples of such especially preferred compounds are compounds C.1.C-2.1 to C.1.C-2.397 of core compound C.1 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.2. C-2.1 to C.2. C-2.397 of core compound C.2 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.3. C-2.1 to C.3. C-2.397 of core compound C.3 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.4. C-2.1 to C.4. C-2.397 of core compound C.4 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.5. C-2.1 to C.5. C-2.397 of core compound C.5 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.6. C-2.1 to C.6. C-2.397 of core compound C.6 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.7. C-2.1 to C.7. C-2.397 of core compound C.7 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.8. C-2.1 to C.8. C-2.397 of core compound C.8 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.9. C-2.1 to C.9. C-2.397 of core compound C.9 defined in table C, wherein the R 3 is selected respectively each from Het- 2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.10. C-2.1 to C.10. C-2.397 of core compound C.10 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.1 1.C-2.1 to C.1 1.C-2.397 of core compound C.1 1 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.12. C-2.1 to C.12. C-2.397 of core compound C.12 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.13. C-2.1 to C.13. C-2.397 of core compound C.13 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.14. C-2.1 to C.14. C-2.397 of core compound C.14 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.15. C-2.1 to C.15. C-2.397 of core compound C.15 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.16. C-2.1 to C.16. C-2.397 of core compound C.16 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.17. C-2.1 to C.17. C-2.397 of core compound C.17 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.18. C-2.1 to C.18. C-2.397 of core compound C.18 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.19. C-2.1 to C.19. C-2.397 of core compound C.19 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.20. C-2.1 to C.20. C-2.397 of core compound C.20 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.21. C-2.1 to C.21. C-2.397 of core compound C.21 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.22. C-2.1 to C.22. C-2.397 of core compound C.22 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.23.C-2.1 to C.23.C-2.397 of core compound C.23 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.24.C-2.1 to C.24.C-2.397 of core compound C.24 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.25.C-2.1 to C.25.C-2.397 of core compound C.25 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.26.C-2.1 to C.26.C-2.397 of core compound C.26 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.27.C-2.1 to C.27.C-2.397 of core compound C.27 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.28.C-2.1 to C.28.C-2.397 of core compound C.28 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.29.C-2.1 to C.29.C-2.397 of core compound C.29 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.30.C-2.1 to C.30.C-2.397 of core compound C.30 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.31.C-2.1 to C.31.C-2.397 of core compound C.31 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.32. C-2.1 to C.32. C-2.397 of core compound C.32 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.33. C-2.1 to C.33. C-2.397 of core compound C.33 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.34. C-2.1 to C.34. C-2.397 of core compound C.34 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.35.C-2.1 to C.35.C-2.397 of core compound C.35 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.36.C-2.1 to C.36.C-2.397 of core compound C.36 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.37.C-2.1 to C.37.C-2.397 of core compound C.37 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.38.C-2.1 to C.38.C-2.397 of core compound C.38 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.39.C-2.1 to C.39.C-2.397 of core compound C.39 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.40.C-2.1 to C.40.C-2.397 of core compound C.40 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.41.C-2.1 to C.41.C-2.397 of core compound C.41 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.42.C-2.1 to C.42.C-2.397 of core compound C.42 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.43.C-2.1 to C.43.C-2.397 of core compound C.43 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.44.C-2.1 to C.44.C-2.397 of core compound C.44 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.45.C-2.1 to C.45.C-2.397 of core compound C.45 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.46.C-2.1 to C.46.C-2.397 of core compound C.46 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.47.C-2.1 to C.47.C-2.397 of core compound C.47 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.48.C-2.1 to C.48.C-2.397 of core compound C.48 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.49.C-2.1 to C.49.C-2.397 of core compound C.49 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.50.C-2.1 to C.50.C-2.397 of core compound C.50 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.51.C-2.1 to C.51.C-2.397 of core compound C.51 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.52.C-2.1 to C.52.C-2.397 of core compound C.52 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.53.C-2.1 to C.53.C-2.397 of core compound C.53 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.54.C-2.1 to C.54.C-2.397 of core compound C.54 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.55.C-2.1 to C.55.C-2.397 of core compound C.55 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.56.C-2.1 to C.56.C-2.397 of core compound C.56 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.57.C-2.1 to C.57.C-2.397 of core compound C.57 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.58.C-2.1 to C.58.C-2.397 of core compound C.58 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.59.C-2.1 to C.59.C-2.397 of core compound C.59 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.60.C-2.1 to C.60.C-2.397 of core compound C.60 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.61.C-2.1 to C.61.C-2.397 of core compound C.61 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.62.C-2.1 to C.62.C-2.397 of core compound C.62 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.63.C-2.1 to C.63.C-2.397 of core compound C.63 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.64.C-2.1 to C.64.C-2.397 of core compound C.64 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.65.C-2.1 to C.65.C-2.397 of core compound C.65 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.66.C-2.1 to C.66.C-2.397 of core compound C.66 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.67.C-2.1 to C.67.C-2.397 of core compound C.67 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.68.C-2.1 to C.68.C-2.397 of core compound C.68 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.69.C-2.1 to C.69.C-2.397 of core compound C.69 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.70.C-2.1 to C.70.C-2.397 of core compound C.70 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.71.C-2.1 to C.71.C-2.397 of core compound C.71 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.72.C-2.1 to C.72.C-2.397 of core compound C.72 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.73.C-2.1 to C.73.C-2.397 of core compound C.73 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.74.C-2.1 to C.74.C-2.397 of core compound C.74 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.75.C-2.1 to C.75.C-2.397 of core compound C.75 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.76.C-2.1 to C.76.C-2.397 of core compound C.76 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.77.C-2.1 to C.77.C-2.397 of core compound C.77 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.78.C-2.1 to C.78.C-2.397 of core compound C.78 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.79.C-2.1 to C.79.C-2.397 of core compound C.79 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.80.C-2.1 to C.80.C-2.397 of core compound C.80 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.81.C-2.1 to C.81.C-2.397 of core compound C.81 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.82.C-2.1 to C.82.C-2.397 of core compound C.82 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.83.C-2.1 to C.83.C-2.397 of core compound C.83 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.84.C-2.1 to C.84.C-2.397 of core compound C.84 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.85.C-2.1 to C.85.C-2.397 of core compound C.85 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.86.C-2.1 to C.86.C-2.397 of core compound C.86 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.87.C-2.1 to C.87.C-2.397 of core compound C.87 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.88.C-2.1 to C.88.C-2.397 of core compound C.88 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.89.C-2.1 to C.89.C-2.397 of core compound C.89 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.90.C-2.1 to C.90.C-2.397 of core compound C.90 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.91.C-2.1 to C.91.C-2.397 of core compound C.91 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.92. C-2.1 to C.92. C-2.397 of core compound C.92 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.93. C-2.1 to C.93. C-2.397 of core compound C.93 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.94. C-2.1 to C.94. C-2.397 of core compound C.94 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.95.C-2.1 to C.95.C-2.397 of core compound C.95 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.96.C-2.1 to C.96.C-2.397 of core compound C.96 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.97.C-2.1 to C.97.C-2.397 of core compound C.97 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.98.C-2.1 to C.98.C-2.397 of core compound C.98 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.99.C-2.1 to C.99.C-2.397 of core compound C.99 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.100.C-2.1 to C.100.C- 2.397 of core compound C.100 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.101.C-2.1 to C.101.C- 2.397 of core compound C.101 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.102.C-2.1 to C.102.C- 2.397 of core compound C.102 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.103.C-2.1 to C.103.C- 2.397 of core compound C.103 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.104.C-2.1 to C.104.C- 2.397 of core compound C.104 defined in table C, wherein the R 3 is selected respectively each from Het-2.1 to Het-2.397 as defined in table H2.
  • Examples of such especially preferred compounds are compounds C.1.C-3.1 to C.1.C-3.17 of core compound C.1 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.2.C-3.1 to C.2.C-3.17 of core compound C.2 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.3.C-3.1 to C.3.C-3.17 of core compound C.3 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.4.C-3.1 to C.4.C-3.17 of core compound C.4 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.5.C-3.1 to C.5.C-3.17 of core compound C.5 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.6.C-3.1 to C.6.C-3.17 of core compound C.6 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.7.C-3.1 to C.7.C-3.17 of core compound C.7 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.8.C-3.1 to C.8.C-3.17 of core compound C.8 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.9.C-3.1 to C.9.C-3.17 of core compound C.9 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.10.C-3.1 to C.10.C-3.17 of core compound C.10 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.1 1.C-3.1 to C.1 1.C-3.17 of core compound C.1 1 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.12.C-3.1 to C.12.C-3.17 of core compound C.12 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.13.C-3.1 to C.13.C-3.17 of core compound C.13 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.14.C-3.1 to C.14.C-3.17 of core compound C.14 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.15.C-3.1 to C.15.C-3.17 of core compound C.15 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.16.C-3.1 to C.16.C-3.17 of core compound C.16 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.17.C-3.1 to C.17.C-3.17 of core compound C.17 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.18.C-3.1 to C.18.C-3.17 of core compound C.18 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.19.C-3.1 to C.19.C-3.17 of core compound C.19 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.20.C-3.1 to C.20.C-3.17 of core compound C.20 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.21.C-3.1 to C.21.C-3.17 of core compound C.21 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.22.C-3.1 to C.22.C-3.17 of core compound C.22 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.23.C-3.1 to C.23.C-3.17 of core compound C.23 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.24.C-3.1 to C.24.C-3.17 of core compound C.24 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.25.C-3.1 to C.25.C-3.17 of core compound C.25 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.26.C-3.1 to C.26.C-3.17 of core compound C.26 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.27.C-3.1 to C.27.C-3.17 of core compound C.27 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.28.C-3.1 to C.28.C-3.17 of core compound C.28 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.29.C-3.1 to C.29.C-3.17 of core compound C.29 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.30.C-3.1 to C.30.C-3.17 of core compound C.30 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.31.C-3.1 to C.31.C-3.17 of core compound C.31 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.32.C-3.1 to C.32.C-3.17 of core compound C.32 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.33.C-3.1 to C.33.C-3.17 of core compound C.33 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.34.C-3.1 to C.34.C-3.17 of core compound C.34 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.35.C-3.1 to C.35.C-3.17 of core compound C.35 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.36.C-3.1 to C.36.C-3.17 of core compound C.36 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.37.C-3.1 to C.37.C-3.17 of core compound C.37 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.38.C-3.1 to C.38.C-3.17 of core compound C.38 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.39.C-3.1 to C.39.C-3.17 of core compound C.39 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.40.C-3.1 to C.40.C-3.17 of core compound C.40 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.41.C-3.1 to C.41.C-3.17 of core compound C.41 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.42.C-3.1 to C.42.C-3.17 of core compound C.42 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.43.C-3.1 to C.43.C-3.17 of core compound C.43 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.44.C-3.1 to C.44.C-3.17 of core compound C.44 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.45.C-3.1 to C.45.C-3.17 of core compound C.45 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.46.C-3.1 to C.46.C-3.17 of core compound C.46 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.47.C-3.1 to C.47.C-3.17 of core compound C.47 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.48.C-3.1 to C.48.C-3.17 of core compound C.48 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.49.C-3.1 to C.49.C-3.17 of core compound C.49 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.50.C-3.1 to C.50.C-3.17 of core compound C.50 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.51.C-3.1 to C.51.C-3.17 of core compound C.51 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.52.C-3.1 to C.52.C-3.17 of core compound C.52 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.53.C-3.1 to C.53.C-3.17 of core compound C.53 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.54.C-3.1 to C.54.C-3.17 of core compound C.54 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.55.C-3.1 to C.55.C-3.17 of core compound C.55 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.56.C-3.1 to C.56.C-3.17 of core compound C.56 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.57.C-3.1 to C.57.C-3.17 of core compound C.57 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.58.C-3.1 to C.58.C-3.17 of core compound C.58 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.59.C-3.1 to C.59.C-3.17 of core compound C.59 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.60.C-3.1 to C.60.C-3.17 of core compound C.60 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.61.C-3.1 to C.61.C-3.17 of core compound C.61 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.62.C-3.1 to C.62.C-3.17 of core compound C.62 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.63.C-3.1 to C.63.C-3.17 of core compound C.63 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.64.C-3.1 to C.64.C-3.17 of core compound C.64 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.65.C-3.1 to C.65.C-3.17 of core compound C.65 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.66.C-3.1 to C.66.C-3.17 of core compound C.66 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.67.C-3.1 to C.67.C-3.17 of core compound C.67 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.68.C-3.1 to C.68.C-3.17 of core compound C.68 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.69.C-3.1 to C.69.C-3.17 of core compound C.69 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.70.C-3.1 to C.70.C-3.17 of core compound C.70 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.71.C-3.1 to C.71.C-3.17 of core compound C.71 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.72.C-3.1 to C.72.C-3.17 of core compound C.72 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.73.C-3.1 to C.73.C-3.17 of core compound C.73 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.74.C-3.1 to C.74.C-3.17 of core compound C.74 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.75.C-3.1 to C.75.C-3.17 of core compound C.75 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.76.C-3.1 to C.76.C-3.17 of core compound C.76 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.77.C-3.1 to C.77.C-3.17 of core compound C.77 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.78.C-3.1 to C.78.C-3.17 of core compound C.78 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.79.C-3.1 to C.79.C-3.17 of core compound C.79 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.80.C-3.1 to C.80.C-3.17 of core compound C.80 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.81.C-3.1 to C.81.C-3.17 of core compound C.81 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.82.C-3.1 to C.82.C-3.17 of core compound C.82 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.83.C-3.1 to C.83.C-3.17 of core compound C.83 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.84.C-3.1 to C.84.C-3.17 of core compound C.84 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.85.C-3.1 to C.85.C-3.17 of core compound C.85 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.86.C-3.1 to C.86.C-3.17 of core compound C.86 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.87.C-3.1 to C.87.C-3.17 of core compound C.87 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.88.C-3.1 to C.88.C-3.17 of core compound C.88 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.89.C-3.1 to C.89.C-3.17 of core compound C.89 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.90.C-3.1 to C.90.C-3.17 of core compound C.90 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.91.C-3.1 to C.91.C-3.17 of core compound C.91 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.92.C-3.1 to C.92.C-3.17 of core compound C.92 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.93.C-3.1 to C.93.C-3.17 of core compound C.93 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.94.C-3.1 to C.94.C-3.17 of core compound C.94 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.95.C-3.1 to C.95.C-3.17 of core compound C.95 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.96.C-3.1 to C.96.C-3.17 of core compound C.96 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.97.C-3.1 to C.97.C-3.17 of core compound C.97 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.98.C-3.1 to C.98.C-3.17 of core compound C.98 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.99.C-3.1 to C.99.C-3.17 of core compound C.99 defined in table C, wherein the R 3 is selected respectively each from Het- 3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.100.C-3.1 to C.100.C-3.17 of core compound C.100 defined in table C, wherein the R 3 is selected respectively each from Het-3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.101.C-3.1 to C.101.C-3.17 of core compound C.101 defined in table C, wherein the R 3 is selected respectively each from Het-3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.102.C-3.1 to C.102.C-3.17 of core compound C.102 defined in table C, wherein the R 3 is selected respectively each from Het-3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.103.C-3.1 to C.103.C-3.17 of core compound C.103 defined in table C, wherein the R 3 is selected respectively each from Het-3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.104.C-3.1 to C.104.C-3.17 of core compound C.104 defined in table C, wherein the R 3 is selected respectively each from Het-3.1 to Het-3.17 as defined in table H3.
  • Examples of such especially preferred compounds are compounds C.1.C-6.1 to C.1.C-6.17 of core compound C.1 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.2.C-6.1 to C.2.C-6.17 of core compound C.2 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.3.C-6.1 to C.3.C-6.17 of core compound C.3 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.4.C-6.1 to C.4.C-6.17 of core compound C.4 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.5.C-6.1 to C.5.C-6.17 of core compound C.5 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.6.C-6.1 to C.6.C-6.17 of core compound C.6 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.7.C-6.1 to C.7.C-6.17 of core compound C.7 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.8.C-6.1 to C.8.C-6.17 of core compound C.8 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.9.C-6.1 to C.9.C-6.17 of core compound C.9 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.10.C-6.1 to C.10.C-6.17 of core compound C.10 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.1 1.C-6.1 to C.1 1.C-6.17 of core compound C.1 1 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.12.C-6.1 to C.12.C-6.17 of core compound C.12 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.13.C-6.1 to C.13.C-6.17 of core compound C.13 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.14.C-6.1 to C.14.C-6.17 of core compound C.14 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.15.C-6.1 to C.15.C-6.17 of core compound C.15 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.16.C-6.1 to C.16.C-6.17 of core compound C.16 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.17.C-6.1 to C.17.C-6.17 of core compound C.17 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.18.C-6.1 to C.18.C-6.17 of core compound C.18 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.19.C-6.1 to C.19.C-6.17 of core compound C.19 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.20.C-6.1 to C.20.C-6.17 of core compound C.20 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.21.C-6.1 to C.21.C-6.17 of core compound C.21 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.22.C-6.1 to C.22.C-6.17 of core compound C.22 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.23.C-6.1 to C.23.C-6.17 of core compound C.23 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.24.C-6.1 to C.24.C-6.17 of core compound C.24 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.25.C-6.1 to C.25.C-6.17 of core compound C.25 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.26.C-6.1 to C.26.C-6.17 of core compound C.26 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.27.C-6.1 to C.27.C-6.17 of core compound C.27 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.28.C-6.1 to C.28.C-6.17 of core compound C.28 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.29.C-6.1 to C.29.C-6.17 of core compound C.29 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.30.C-6.1 to C.30.C-6.17 of core compound C.30 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.31.C-6.1 to C.31.C-6.17 of core compound C.31 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.32.C-6.1 to C.32.C-6.17 of core compound C.32 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.33.C-6.1 to C.33.C-6.17 of core compound C.33 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.34.C-6.1 to C.34.C-6.17 of core compound C.34 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.35.C-6.1 to C.35.C-6.17 of core compound C.35 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.36.C-6.1 to C.36.C-6.17 of core compound C.36 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.37.C-6.1 to C.37.C-6.17 of core compound C.37 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.38.C-6.1 to C.38.C-6.17 of core compound C.38 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.39.C-6.1 to C.39.C-6.17 of core compound C.39 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.40.C-6.1 to C.40.C-6.17 of core compound C.40 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.41.C-6.1 to C.41.C-6.17 of core compound C.41 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.42.C-6.1 to C.42.C-6.17 of core compound C.42 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.43.C-6.1 to C.43.C-6.17 of core compound C.43 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.44.C-6.1 to C.44.C-6.17 of core compound C.44 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.45.C-6.1 to C.45.C-6.17 of core compound C.45 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.46.C-6.1 to C.46.C-6.17 of core compound C.46 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.47.C-6.1 to C.47.C-6.17 of core compound C.47 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.48.C-6.1 to C.48.C-6.17 of core compound C.48 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.49.C-6.1 to C.49.C-6.17 of core compound C.49 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.50.C-6.1 to C.50.C-6.17 of core compound C.50 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.51.C-6.1 to C.51.C-6.17 of core compound C.51 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.52.C-6.1 to C.52.C-6.17 of core compound C.52 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.53.C-6.1 to C.53.C-6.17 of core compound C.53 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.54.C-6.1 to C.54.C-6.17 of core compound C.54 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.55.C-6.1 to C.55.C-6.17 of core compound C.55 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.56.C-6.1 to C.56.C-6.17 of core compound C.56 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.57.C-6.1 to C.57.C-6.17 of core compound C.57 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.58.C-6.1 to C.58.C-6.17 of core compound C.58 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.59.C-6.1 to C.59.C-6.17 of core compound C.59 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.60.C-6.1 to C.60.C-6.17 of core compound C.60 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.61.C-6.1 to C.61.C-6.17 of core compound C.61 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.62.C-6.1 to C.62.C-6.17 of core compound C.62 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.63.C-6.1 to C.63.C-6.17 of core compound C.63 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.64.C-6.1 to C.64.C-6.17 of core compound C.64 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.65.C-6.1 to C.65.C-6.17 of core compound C.65 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.66.C-6.1 to C.66.C-6.17 of core compound C.66 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.67.C-6.1 to C.67.C-6.17 of core compound C.67 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.68.C-6.1 to C.68.C-6.17 of core compound C.68 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.69.C-6.1 to C.69.C-6.17 of core compound C.69 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.70.C-6.1 to C.70.C-6.17 of core compound C.70 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.71.C-6.1 to C.71.C-6.17 of core compound C.71 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.72.C-6.1 to C.72.C-6.17 of core compound C.72 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.73.C-6.1 to C.73.C-6.17 of core compound C.73 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.74.C-6.1 to C.74.C-6.17 of core compound C.74 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.75.C-6.1 to C.75.C-6.17 of core compound C.75 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.76.C-6.1 to C.76.C-6.17 of core compound C.76 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.77.C-6.1 to C.77.C-6.17 of core compound C.77 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.78.C-6.1 to C.78.C-6.17 of core compound C.78 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.79.C-6.1 to C.79.C-6.17 of core compound C.79 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.80.C-6.1 to C.80.C-6.17 of core compound C.80 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.81.C-6.1 to C.81.C-6.17 of core compound C.81 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.82.C-6.1 to C.82.C-6.17 of core compound C.82 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.83.C-6.1 to C.83.C-6.17 of core compound C.83 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.84.C-6.1 to C.84.C-6.17 of core compound C.84 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.85.C-6.1 to C.85.C-6.17 of core compound C.85 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.86.C-6.1 to C.86.C-6.17 of core compound C.86 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.87.C-6.1 to C.87.C-6.17 of core compound C.87 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.88.C-6.1 to C.88.C-6.17 of core compound C.88 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.89.C-6.1 to C.89.C-6.17 of core compound C.89 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.90.C-6.1 to C.90.C-6.17 of core compound C.90 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.91.C-6.1 to C.91.C-6.17 of core compound C.91 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.92.C-6.1 to C.92.C-6.17 of core compound C.92 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.93.C-6.1 to C.93.C-6.17 of core compound C.93 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.94.C-6.1 to C.94.C-6.17 of core compound C.94 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.95.C-6.1 to C.95.C-6.17 of core compound C.95 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.96.C-6.1 to C.96.C-6.17 of core compound C.96 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.97.C-6.1 to C.97.C-6.17 of core compound C.97 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.98.C-6.1 to C.98.C-6.17 of core compound C.98 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.99.C-6.1 to C.99.C-6.17 of core compound C.99 defined in table C, wherein the R 3 is selected respectively each from Het- 6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.100.C-6.1 to C.100.C-6.17 of core compound C.100 defined in table C, wherein the R 3 is selected respectively each from Het-6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.101.C-6.1 to C.101.C-6.17 of core compound C.101 defined in table C, wherein the R 3 is selected respectively each from Het-6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.102.C-6.1 to C.102.C-6.17 of core compound C.102 defined in table C, wherein the R 3 is selected respectively each from Het-6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.103.C-6.1 to C.103.C-6.17 of core compound C.103 defined in table C, wherein the R 3 is selected respectively each from Het-6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.104.C-6.1 to C.104.C-6.17 of core compound C.104 defined in table C, wherein the R 3 is selected respectively each from Het-6.1 to Het-6.17 as defined in table H6.
  • Examples of such especially preferred compounds are compounds C.1.C-36.1 to C.1.C-36.147 of core compound C.1 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.2.C-36.1 to C.2.C-36.147 of core compound C.2 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.3.C-36.1 to C.3.C-36.147 of core compound C.3 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.4.C-36.1 to C.4.C-36.147 of core compound C.4 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.5.C-36.1 to C.5.C-36.147 of core compound C.5 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.6.C-36.1 to C.6.C-36.147 of core compound C.6 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.7.C-36.1 to C.7.C-36.147 of core compound C.7 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.8.C-36.1 to C.8.C-36.147 of core compound C.8 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.9.C-36.1 to C.9.C-36.147 of core compound C.9 defined in table C, wherein the R 3 is selected respectively each from Het- 36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.10.C-36.1 to C.10.C- 36.147 of core compound C.10 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.1 1.C-36.1 to C.1 1.C- 36.147 of core compound C.1 1 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.12. C-36.1 to C.12.C- 36.147 of core compound C.12 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.13. C-36.1 to C.13.C- 36.147 of core compound C.13 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.14. C-36.1 to C.14.C-
  • Examples of such especially preferred compounds are compounds C.15. C-36.1 to C.15.C- 36.147 of core compound C.15 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.16. C-36.1 to C.16.C- 36.147 of core compound C.16 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.17. C-36.1 to C.17.C- 36.147 of core compound C.17 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.18. C-36.1 to C.18.C- 36.147 of core compound C.18 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.19. C-36.1 to C.19.C-
  • Examples of such especially preferred compounds are compounds C.20. C-36.1 to C.20.C- 36.147 of core compound C.20 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.21. C-36.1 to C.21.C- 36.147 of core compound C.21 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.22. C-36.1 to C.22.C- 36.147 of core compound C.22 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.23.C-36.1 to C.23.C- 36.147 of core compound C.23 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.24.C-36.1 to C.24.C- 36.147 of core compound C.24 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.25.C-36.1 to C.25.C- 36.147 of core compound C.25 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.26.C-36.1 to C.26.C-
  • Examples of such especially preferred compounds are compounds C.27.C-36.1 to C.27.C- 36.147 of core compound C.27 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.28.C-36.1 to C.28.C- 36.147 of core compound C.28 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.29.C-36.1 to C.29.C- 36.147 of core compound C.29 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.30.C-36.1 to C.30.C- 36.147 of core compound C.30 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.31.C-36.1 to C.31.C-
  • Examples of such especially preferred compounds are compounds C.32. C-36.1 to C.32.C- 36.147 of core compound C.32 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.33. C-36.1 to C.33.C- 36.147 of core compound C.33 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.34. C-36.1 to C.34.C- 36.147 of core compound C.34 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.35.C-36.1 to C.35.C- 36.147 of core compound C.35 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.36.C-36.1 to C.36.C- 36.147 of core compound C.36 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.37.C-36.1 to C.37.C- 36.147 of core compound C.37 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.38.C-36.1 to C.38.C-
  • Examples of such especially preferred compounds are compounds C.39.C-36.1 to C.39.C- 36.147 of core compound C.39 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.40.C-36.1 to C.40.C- 36.147 of core compound C.40 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.41.C-36.1 to C.41.C- 36.147 of core compound C.41 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.42.C-36.1 to C.42.C- 36.147 of core compound C.42 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.43.C-36.1 to C.43.C-
  • Examples of such especially preferred compounds are compounds C.44.C-36.1 to C.44.C- 36.147 of core compound C.44 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.45.C-36.1 to C.45.C- 36.147 of core compound C.45 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.46.C-36.1 to C.46.C- 36.147 of core compound C.46 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.47.C-36.1 to C.47.C- 36.147 of core compound C.47 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.48.C-36.1 to C.48.C- 36.147 of core compound C.48 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.49.C-36.1 to C.49.C- 36.147 of core compound C.49 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.50.C-36.1 to C.50.C-
  • Examples of such especially preferred compounds are compounds C.51.C-36.1 to C.51.C- 36.147 of core compound C.51 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.52.C-36.1 to C.52.C- 36.147 of core compound C.52 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.53.C-36.1 to C.53.C- 36.147 of core compound C.53 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.54.C-36.1 to C.54.C- 36.147 of core compound C.54 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.55.C-36.1 to C.55.C-
  • Examples of such especially preferred compounds are compounds C.56.C-36.1 to C.56.C- 36.147 of core compound C.56 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.57.C-36.1 to C.57.C- 36.147 of core compound C.57 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.58.C-36.1 to C.58.C- 36.147 of core compound C.58 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.59.C-36.1 to C.59.C- 36.147 of core compound C.59 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.60.C-36.1 to C.60.C- 36.147 of core compound C.60 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.61.C-36.1 to C.61.C- 36.147 of core compound C.61 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.62.C-36.1 to C.62.C-
  • Examples of such especially preferred compounds are compounds C.63.C-36.1 to C.63.C- 36.147 of core compound C.63 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.64.C-36.1 to C.64.C- 36.147 of core compound C.64 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.65.C-36.1 to C.65.C- 36.147 of core compound C.65 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.66.C-36.1 to C.66.C- 36.147 of core compound C.66 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.67.C-36.1 to C.67.C-
  • Examples of such especially preferred compounds are compounds C.68.C-36.1 to C.68.C- 36.147 of core compound C.68 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.69.C-36.1 to C.69.C- 36.147 of core compound C.69 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.70.C-36.1 to C.70.C- 36.147 of core compound C.70 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.71.C-36.1 to C.71.C- 36.147 of core compound C.71 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.72.C-36.1 to C.72.C- 36.147 of core compound C.72 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.73.C-36.1 to C.73.C- 36.147 of core compound C.73 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.74.C-36.1 to C.74.C-
  • Examples of such especially preferred compounds are compounds C.75.C-36.1 to C.75.C- 36.147 of core compound C.75 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.76.C-36.1 to C.76.C- 36.147 of core compound C.76 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.77.C-36.1 to C.77.C- 36.147 of core compound C.77 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.78.C-36.1 to C.78.C- 36.147 of core compound C.78 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.79.C-36.1 to C.79.C-
  • Examples of such especially preferred compounds are compounds C.80.C-36.1 to C.80.C- 36.147 of core compound C.80 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.81.C-36.1 to C.81.C- 36.147 of core compound C.81 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.82.C-36.1 to C.82.C- 36.147 of core compound C.82 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.83.C-36.1 to C.83.C- 36.147 of core compound C.83 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.84.C-36.1 to C.84.C- 36.147 of core compound C.84 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.85.C-36.1 to C.85.C- 36.147 of core compound C.85 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.86.C-36.1 to C.86.C-
  • Examples of such especially preferred compounds are compounds C.87.C-36.1 to C.87.C- 36.147 of core compound C.87 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.88.C-36.1 to C.88.C- 36.147 of core compound C.88 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.89.C-36.1 to C.89.C- 36.147 of core compound C.89 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.90.C-36.1 to C.90.C- 36.147 of core compound C.90 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.91.C-36.1 to C.91.C-
  • Examples of such especially preferred compounds are compounds C.92. C-36.1 to C.92.C- 36.147 of core compound C.92 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.93. C-36.1 to C.93.C- 36.147 of core compound C.93 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.94. C-36.1 to C.94.C- 36.147 of core compound C.94 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.95.C-36.1 to C.95.C- 36.147 of core compound C.95 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.96.C-36.1 to C.96.C- 36.147 of core compound C.96 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.97.C-36.1 to C.97.C- 36.147 of core compound C.97 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.98.C-36.1 to C.98.C-
  • Examples of such especially preferred compounds are compounds C.99.C-36.1 to C.99.C- 36.147 of core compound C.99 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.100.C-36.1 to C.100.C- 36.147 of core compound C.100 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.101.C-36.1 to C.101.C- 36.147 of core compound C.101 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.102.C-36.1 to C.102.C- 36.147 of core compound C.102 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.103.C-36.1 to C.103.C- 36.147 of core compound C.103 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.104.C-36.1 to C.104.C- 36.147 of core compound C.104 defined in table C, wherein the R 3 is selected respectively each from Het-36.1 to Het-36.147 as defined in table H36.
  • Examples of such especially preferred compounds are compounds C.1.C-37.1 to C.1.C-37.17 of core compound C.1 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.2.C-37.1 to C.2.C-37.17 of core compound C.2 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.3.C-37.1 to C.3.C-37.17 of core compound C.3 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.4.C-37.1 to C.4.C-37.17 of core compound C.4 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.5.C-37.1 to C.5.C-37.17 of core compound C.5 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.6.C-37.1 to C.6.C-37.17 of core compound C.6 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.7.C-37.1 to C.7.C-37.17 of core compound C.7 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.
  • Examples of such especially preferred compounds are compounds C.8.C-37.1 to C.8.C-37.17 of core compound C.8 defined in table C, wherein the R 3 is selected respectively each from Het- 37.1 to Het-37.17 as defined in table H37.

Abstract

L'invention concerne des composés de pyridylidène de formule (I), des énantiomères, des diastéréomères et des sels de ceux-ci ainsi que des compositions comprenant ces composés. L'invention concerne également des procédés et des utilisations de ces composés de pyridylidène N-substitués et des compositions les comprenant, pour lutter contre des animaux nuisibles. En outre, l'invention concerne des procédés pesticides d'application desdits composés de pyridylidène N-substitués. Les composés de pyridylidène selon l'invention sont définis par la formule suivante (I) dans laquelle k, X, R1, R2, R3, R4a, R4b1, R4b2, R4c1, Rc2, R4d1, R4d2 et R6 sont tels que définis dans les revendications et la description.
PCT/EP2014/068415 2013-08-30 2014-08-29 Composés de pyridylidène n-substitués et leurs dérivés utilisables pour lutter contre les animaux nuisibles WO2015028630A1 (fr)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016198613A1 (fr) 2015-06-11 2016-12-15 Basf Se Composés n-(thio)acylimino
WO2016198611A1 (fr) 2015-06-11 2016-12-15 Basf Se Composés hétérocycliques n-(thio)acylimino
US9783523B2 (en) 2013-11-22 2017-10-10 Basf Se N-acylimino heterocyclic compounds
US10206397B2 (en) 2013-09-19 2019-02-19 Basf Se N-acylimino heterocyclic compounds
US11142514B2 (en) 2015-10-02 2021-10-12 Basf Se Imino compounds with a 2-chloropyrimidin-5-yl substituent as pest-control agents

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Publication number Priority date Publication date Assignee Title
EP2628389A1 (fr) * 2010-08-31 2013-08-21 Meiji Seika Pharma Co., Ltd. Agent de lutte contre des organismes nuisibles
EP2634174A2 (fr) * 2012-02-29 2013-09-04 Meiji Seika Pharma Co., Ltd. Dérivé hétérocyclique contenant de l'azote ayant un groupe 2-imino et agent antiparasitaire comprenant celui-ci

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2628389A1 (fr) * 2010-08-31 2013-08-21 Meiji Seika Pharma Co., Ltd. Agent de lutte contre des organismes nuisibles
EP2634174A2 (fr) * 2012-02-29 2013-09-04 Meiji Seika Pharma Co., Ltd. Dérivé hétérocyclique contenant de l'azote ayant un groupe 2-imino et agent antiparasitaire comprenant celui-ci

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10206397B2 (en) 2013-09-19 2019-02-19 Basf Se N-acylimino heterocyclic compounds
US10757938B2 (en) 2013-09-19 2020-09-01 Basf Se N-acylimino Heterocyclic Compounds
US9783523B2 (en) 2013-11-22 2017-10-10 Basf Se N-acylimino heterocyclic compounds
WO2016198613A1 (fr) 2015-06-11 2016-12-15 Basf Se Composés n-(thio)acylimino
WO2016198611A1 (fr) 2015-06-11 2016-12-15 Basf Se Composés hétérocycliques n-(thio)acylimino
US11142514B2 (en) 2015-10-02 2021-10-12 Basf Se Imino compounds with a 2-chloropyrimidin-5-yl substituent as pest-control agents

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