WO2015020545A3 - New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs - Google Patents

New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs Download PDF

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Publication number
WO2015020545A3
WO2015020545A3 PCT/PL2014/050047 PL2014050047W WO2015020545A3 WO 2015020545 A3 WO2015020545 A3 WO 2015020545A3 PL 2014050047 W PL2014050047 W PL 2014050047W WO 2015020545 A3 WO2015020545 A3 WO 2015020545A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkylaminoalkanols
phenoxy
ethoxy
drugs
preparation
Prior art date
Application number
PCT/PL2014/050047
Other languages
French (fr)
Other versions
WO2015020545A2 (en
Inventor
Anna Waszkielewicz
Agnieszka GUNIA
Henryk Marona
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Publication of WO2015020545A2 publication Critical patent/WO2015020545A2/en
Publication of WO2015020545A3 publication Critical patent/WO2015020545A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention discloses new derivatives of N-[(phenoxy)ethoxy]alkylaminoalkanols with the structure which show pharmacological activity, especially in therapy and/or prophylaxis disorders and/or symptoms withneurological etiology.
PCT/PL2014/050047 2013-08-09 2014-08-07 New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs WO2015020545A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL405040A PL225258B1 (en) 2013-08-09 2013-08-09 New derivatives of N-[(phenoxy)ethoxy]alkylamino alkanols and their application for manufacturing of medicines
PLP.405040 2013-08-09

Publications (2)

Publication Number Publication Date
WO2015020545A2 WO2015020545A2 (en) 2015-02-12
WO2015020545A3 true WO2015020545A3 (en) 2015-04-02

Family

ID=51541274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2014/050047 WO2015020545A2 (en) 2013-08-09 2014-08-07 New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs

Country Status (2)

Country Link
PL (1) PL225258B1 (en)
WO (1) WO2015020545A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2009093916A2 (en) * 2008-01-22 2009-07-30 Uniwersytet Jagiellonski Derivatives of aminoalkanols, method of obtaining aminoalkanols and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071552A (en) 1976-05-19 1978-01-31 Ayerst Mckenna And Harrison Ltd. Aryloxy aminobutanols, their preparation and use thereof
PL126478B1 (en) 1978-12-19 1983-08-31 Inst Maszyn Spozywczych Temperature and humidity control system in particulary for smoking and steaming chambers
PL212489A1 (en) 1978-12-29 1980-07-01 Zaklady Urzadzen Chem
EP1809273B1 (en) 2004-09-16 2010-04-14 Janssen Pharmaceutica N.V. Use of 2-phenyl-1,2-ethanediol-(di)carbamates for treating epileptogenesis
PL220733B1 (en) 2012-11-07 2015-12-31 Univ Jagielloński New alkanolamides cinnamic acid derivatives and the use of cinnamic acid derivatives alkanolamides the preparation of medicaments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2009093916A2 (en) * 2008-01-22 2009-07-30 Uniwersytet Jagiellonski Derivatives of aminoalkanols, method of obtaining aminoalkanols and their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOLDFARB, DAVID SCOTT: "Method using lifespan-altering compounds for altering the lifespan of eukaryotic organisms, and screening for such compounds", XP002732387, retrieved from STN Database accession no. 2009:846113 *

Also Published As

Publication number Publication date
PL405040A1 (en) 2015-02-16
WO2015020545A2 (en) 2015-02-12
PL225258B1 (en) 2017-03-31

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