WO2015019238A8 - Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one - Google Patents

Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one Download PDF

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Publication number
WO2015019238A8
WO2015019238A8 PCT/IB2014/063486 IB2014063486W WO2015019238A8 WO 2015019238 A8 WO2015019238 A8 WO 2015019238A8 IB 2014063486 W IB2014063486 W IB 2014063486W WO 2015019238 A8 WO2015019238 A8 WO 2015019238A8
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WO
WIPO (PCT)
Prior art keywords
thiazolidin
pyrrolidin
ylcarbonyl
protected
preparation
Prior art date
Application number
PCT/IB2014/063486
Other languages
French (fr)
Other versions
WO2015019238A1 (en
Inventor
Prabhat GIRI
Achyut TENDOLKAR
Ashwini Kumar Kapoor
Dhiren Chandra BARMAN
Asok Nath
Mohan Prasad
Original Assignee
Ranbaxy Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited
Publication of WO2015019238A1 publication Critical patent/WO2015019238A1/en
Publication of WO2015019238A8 publication Critical patent/WO2015019238A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention provides a process for the preparation of an N-protected (5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one of Formula III. The invention also provides a process for the preparation of {(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5- yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone, or salts thereof, using the N-protected (5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one of Formula III.
PCT/IB2014/063486 2013-08-06 2014-07-28 Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one WO2015019238A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2347/DEL/2013 2013-08-06
IN2347DE2013 2013-08-06

Publications (2)

Publication Number Publication Date
WO2015019238A1 WO2015019238A1 (en) 2015-02-12
WO2015019238A8 true WO2015019238A8 (en) 2015-04-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/063486 WO2015019238A1 (en) 2013-08-06 2014-07-28 Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one

Country Status (1)

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WO (1) WO2015019238A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153005A (en) * 2015-08-05 2015-12-16 上海瑞博化学有限公司 Preparation method of 4-carbonyl-proline derivative

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104788353B (en) * 2015-04-07 2018-04-20 四川同晟氨基酸有限公司 A kind of method for synthesizing 4 oxo L proline derivatives
CN105085510B (en) * 2015-09-11 2018-03-02 沧州那瑞化学科技有限公司 A kind of preparation method of the carboxylic acid tert-butyl ester of (S) 4 oxo 2 (carbonyl of thiazolidine 3) pyrrolidines 1
JP2019512460A (en) * 2017-02-03 2019-05-16 グレンマーク・ファーマシューティカルズ・リミテッド Preparation containing oxalate salt of teneligliptin and solvate thereof
JP6985179B2 (en) * 2018-02-27 2021-12-22 田辺三菱製薬株式会社 Method for producing proline amide compound
CN110294748B (en) * 2019-07-25 2020-12-25 浙江沙星科技有限公司 Synthesis method of teneligliptin key intermediate
CN115160306B (en) * 2022-08-04 2024-03-26 上海皓鸿生物医药科技有限公司 Synthetic method of telithromycin intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1950199B1 (en) 2000-08-10 2009-12-02 Mitsubishi Tanabe Pharma Corporation Proline derivatives and use thereof as drugs
GEP20084421B (en) * 2004-05-12 2008-07-10 Pfizer Prod Inc Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
BRPI0607863B8 (en) 2005-02-18 2021-05-25 Mitsubishi Pharma Corp 3-{(2s,4s)-4-[4-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl crystalline salt }thiazolidine and its preparation process
CN103619334A (en) * 2011-01-19 2014-03-05 朱红文 Thiazolidine derivatives and therapeutic use thereof
JP5863789B2 (en) * 2011-06-01 2016-02-17 田辺三菱製薬株式会社 Method for producing pyrazole derivative
BR112015004029B1 (en) * 2012-08-31 2022-03-29 Glenmark Pharmaceuticals Limited Process for preparing teneligliptin, a compound or a salt or hydrate thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153005A (en) * 2015-08-05 2015-12-16 上海瑞博化学有限公司 Preparation method of 4-carbonyl-proline derivative

Also Published As

Publication number Publication date
WO2015019238A1 (en) 2015-02-12

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