WO2015013177A3 - Rapid detection of carbapenemase and beta-lactamase producing bacteria - Google Patents

Rapid detection of carbapenemase and beta-lactamase producing bacteria Download PDF

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Publication number
WO2015013177A3
WO2015013177A3 PCT/US2014/047394 US2014047394W WO2015013177A3 WO 2015013177 A3 WO2015013177 A3 WO 2015013177A3 US 2014047394 W US2014047394 W US 2014047394W WO 2015013177 A3 WO2015013177 A3 WO 2015013177A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbapenemase
beta
producing bacteria
lactamase producing
rapid detection
Prior art date
Application number
PCT/US2014/047394
Other languages
French (fr)
Other versions
WO2015013177A2 (en
Inventor
Raymond Kwong
Original Assignee
Beckman Coulter Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc. filed Critical Beckman Coulter Inc.
Publication of WO2015013177A2 publication Critical patent/WO2015013177A2/en
Publication of WO2015013177A3 publication Critical patent/WO2015013177A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are methods, reagents, kits, and systems for detecting drug-resistant bacteria, particularly carbapenemase and beta-lactamase producing bacteria. The methods involve contacting unlysated bacterial samples with a test composition including an antibiotic drug composition, a dye and monitoring a color change produced as a result of degradation of the antibiotic drug.
PCT/US2014/047394 2013-07-25 2014-07-21 Rapid detection of carbapenemase and beta-lactamase producing bacteria WO2015013177A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361858217P 2013-07-25 2013-07-25
US61/858,217 2013-07-25

Publications (2)

Publication Number Publication Date
WO2015013177A2 WO2015013177A2 (en) 2015-01-29
WO2015013177A3 true WO2015013177A3 (en) 2015-11-26

Family

ID=52393948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/047394 WO2015013177A2 (en) 2013-07-25 2014-07-21 Rapid detection of carbapenemase and beta-lactamase producing bacteria

Country Status (1)

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WO (1) WO2015013177A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201520977D0 (en) * 2015-11-27 2016-01-13 Mast Group Ltd Carbapenemase-producing bacteria detection method
CN106467924B (en) * 2016-09-20 2019-12-20 安徽理工大学 Test method for evaluating in-vitro antibacterial activity of antibacterial substance

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075014A (en) * 1997-06-13 2000-06-13 Northwestern University Inhibitors of β-lactamases and uses therefor
US20080026418A1 (en) * 2002-03-13 2008-01-31 Creighton University Device and direct method for detecting antibiotic-inactivating factors
WO2009048673A2 (en) * 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
US20090275065A1 (en) * 2008-04-30 2009-11-05 Nanyang Technological University Methods and compounds for detecting beta-lactamase activity
US20120196309A1 (en) * 2011-01-28 2012-08-02 Yale University Methods and Kits for Detection of Antibiotic Resistance

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075014A (en) * 1997-06-13 2000-06-13 Northwestern University Inhibitors of β-lactamases and uses therefor
US20080026418A1 (en) * 2002-03-13 2008-01-31 Creighton University Device and direct method for detecting antibiotic-inactivating factors
WO2009048673A2 (en) * 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
US20090275065A1 (en) * 2008-04-30 2009-11-05 Nanyang Technological University Methods and compounds for detecting beta-lactamase activity
US20120196309A1 (en) * 2011-01-28 2012-08-02 Yale University Methods and Kits for Detection of Antibiotic Resistance

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOLAPURE ET AL.: "In Vitro and In Vivo Efficacy of -L actams against Replicating and Slowly Growing/Nonreplicating Mycobacterium tuberculosis", ANTIMICROBIAL AGENTS AND CHEMOTHERAP, vol. 57, no. 6, 1 June 2013 (2013-06-01), pages 2506 - 2510, XP055238134 *

Also Published As

Publication number Publication date
WO2015013177A2 (en) 2015-01-29

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