WO2015012541A3 - Kit de diagnostic précoce de la maladie d'alzheimer - Google Patents

Kit de diagnostic précoce de la maladie d'alzheimer Download PDF

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Publication number
WO2015012541A3
WO2015012541A3 PCT/KR2014/006582 KR2014006582W WO2015012541A3 WO 2015012541 A3 WO2015012541 A3 WO 2015012541A3 KR 2014006582 W KR2014006582 W KR 2014006582W WO 2015012541 A3 WO2015012541 A3 WO 2015012541A3
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WO
WIPO (PCT)
Prior art keywords
mir
alzheimer
dementia
early diagnosis
kit
Prior art date
Application number
PCT/KR2014/006582
Other languages
English (en)
Korean (ko)
Other versions
WO2015012541A2 (fr
Inventor
김명옥
김상태
Original Assignee
경상대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 경상대학교산학협력단 filed Critical 경상대학교산학협력단
Publication of WO2015012541A2 publication Critical patent/WO2015012541A2/fr
Publication of WO2015012541A3 publication Critical patent/WO2015012541A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/155—Particles of a defined size, e.g. nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Urology & Nephrology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

La présente invention concerne un kit de diagnostic précoce de la maladie d'Alzheimer permettant de diagnostiquer la maladie d'Alzheimer de manière précoce, ce kit comprenant une molécule sonde contenant un oligonucléotide pouvant détecter au moins un microARN spécifique de la maladie d'Alzheimer, choisi dans le groupe constitué par miR-200a, miR-181a, miR-124b, miR-146b, miR-34a, miR-106b, miR-153 et miR-155, en vue du diagnostic précoce de la maladie d'Alzheimer.
PCT/KR2014/006582 2013-07-26 2014-07-21 Kit de diagnostic précoce de la maladie d'alzheimer WO2015012541A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0088793 2013-07-26
KR1020130088793A KR101609599B1 (ko) 2013-07-26 2013-07-26 항원 검출용 형광 나노입자 및 그를 이용한 알츠하이머 치매의 조기 진단키트

Publications (2)

Publication Number Publication Date
WO2015012541A2 WO2015012541A2 (fr) 2015-01-29
WO2015012541A3 true WO2015012541A3 (fr) 2015-03-26

Family

ID=52393914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2014/006582 WO2015012541A2 (fr) 2013-07-26 2014-07-21 Kit de diagnostic précoce de la maladie d'alzheimer

Country Status (2)

Country Link
KR (1) KR101609599B1 (fr)
WO (1) WO2015012541A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101734645B1 (ko) * 2015-05-18 2017-05-11 (주)에이엔티랩스 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법
CN105567737A (zh) * 2015-12-30 2016-05-11 广州凯拓生物科技开发有限公司 miRNA-34a过表达重组载体的构建及应用
KR102075558B1 (ko) * 2018-03-07 2020-02-10 광운대학교 산학협력단 스크리닝 목적의 올리고머/모노머 기반 알츠하이머 진단칩과 이를 이용한 분석 방법
EP3807422A1 (fr) * 2018-06-15 2021-04-21 Universitat Autònoma de Barcelona Miarn circulants utilisés en tant que biomarqueurs pour le diagnostic d'une déficience cognitive légère et de la maladie d'alzheimer
CN111269977A (zh) * 2020-02-24 2020-06-12 中国医学科学院医药生物技术研究所 miRNA 200簇作为诊断和/或治疗阿尔茨海默病标志物的应用
CN111521592A (zh) * 2020-05-11 2020-08-11 深圳大学 一种信号放大的荧光检测体系、荧光生物传感器及其用途
KR102321753B1 (ko) * 2021-08-13 2021-11-04 주식회사 알츠코리아 알츠하이머성 치매 조기 진단용 신규 마이크로 rna 바이오마커
KR20230153559A (ko) 2022-04-28 2023-11-07 광운대학교 산학협력단 인터디지털커패시터 기반의 멀티플렉싱 조기 진단을 위한 키트
CN114874198B (zh) * 2022-06-14 2023-08-25 黄淮学院 一种基于罗丹明-铜配合物的Aβ荧光探针及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042222A2 (fr) * 1999-01-15 2000-07-20 Gene Logic Inc. Reactif d'hybridation d'acide nucleique immobilise et procede associe
WO2005118844A1 (fr) * 2004-05-28 2005-12-15 Sirs-Lab Gmbh Ensemble de sonde moleculaire adressable
WO2009009457A1 (fr) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Microréseau de micro-arn spécifique de la maladie d'alzheimer et procédés apparentés
WO2011107606A1 (fr) * 2010-03-04 2011-09-09 Miacom Diagnostics Gmbh Hybridation in situ à fluorescence multiplexe améliorée

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042222A2 (fr) * 1999-01-15 2000-07-20 Gene Logic Inc. Reactif d'hybridation d'acide nucleique immobilise et procede associe
WO2005118844A1 (fr) * 2004-05-28 2005-12-15 Sirs-Lab Gmbh Ensemble de sonde moleculaire adressable
WO2009009457A1 (fr) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Microréseau de micro-arn spécifique de la maladie d'alzheimer et procédés apparentés
WO2011107606A1 (fr) * 2010-03-04 2011-09-09 Miacom Diagnostics Gmbh Hybridation in situ à fluorescence multiplexe améliorée

Also Published As

Publication number Publication date
WO2015012541A2 (fr) 2015-01-29
KR20150014037A (ko) 2015-02-06
KR101609599B1 (ko) 2016-04-07

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