WO2015002754A3 - Novel bicyclic bromodomain inhibitors - Google Patents

Novel bicyclic bromodomain inhibitors Download PDF

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Publication number
WO2015002754A3
WO2015002754A3 PCT/US2014/043423 US2014043423W WO2015002754A3 WO 2015002754 A3 WO2015002754 A3 WO 2015002754A3 US 2014043423 W US2014043423 W US 2014043423W WO 2015002754 A3 WO2015002754 A3 WO 2015002754A3
Authority
WO
WIPO (PCT)
Prior art keywords
bromodomain inhibitors
novel bicyclic
terminal domain
inhibitors
bet
Prior art date
Application number
PCT/US2014/043423
Other languages
French (fr)
Other versions
WO2015002754A2 (en
Inventor
John Frederick QUINN
Ruifang WANG
May Xiaowu Jiang
Gregory Scott MARTIN
Gregory Steven WAGNER
Peter Ronald Young
Bryan Cordell DUFFY
Shuang Liu
Original Assignee
Zenith Epigenetics Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020157035639A priority Critical patent/KR102307566B1/en
Priority to DK14820520.6T priority patent/DK3010503T3/en
Priority to NZ714669A priority patent/NZ714669A/en
Priority to AU2014284616A priority patent/AU2014284616B2/en
Priority to CN201480034817.9A priority patent/CN105407888B/en
Priority to MX2015017045A priority patent/MX365864B/en
Priority to PL14820520T priority patent/PL3010503T3/en
Priority to EP14820520.6A priority patent/EP3010503B1/en
Priority to SG11201510409QA priority patent/SG11201510409QA/en
Priority to SI201431582T priority patent/SI3010503T1/en
Priority to EP20154850.0A priority patent/EP3674300B1/en
Priority to ES14820520T priority patent/ES2806135T3/en
Priority to EA201592143A priority patent/EA035601B1/en
Priority to CA2915838A priority patent/CA2915838C/en
Application filed by Zenith Epigenetics Corp. filed Critical Zenith Epigenetics Corp.
Priority to BR112015031073-7A priority patent/BR112015031073B1/en
Priority to JP2016521848A priority patent/JP6461121B2/en
Publication of WO2015002754A2 publication Critical patent/WO2015002754A2/en
Publication of WO2015002754A3 publication Critical patent/WO2015002754A3/en
Priority to IL242844A priority patent/IL242844B/en
Priority to US14/977,508 priority patent/US9663520B2/en
Priority to ZA2016/00272A priority patent/ZA201600272B/en
Priority to HK16104809.5A priority patent/HK1216722A1/en
Priority to HK16110599.6A priority patent/HK1222335A1/en
Priority to US15/486,256 priority patent/US10010556B2/en
Priority to US15/875,678 priority patent/US10363257B2/en
Priority to AU2019201212A priority patent/AU2019201212C1/en
Priority to US16/440,350 priority patent/US10772892B2/en
Priority to HRP20200854TT priority patent/HRP20200854T1/en
Priority to US16/940,785 priority patent/US11446306B2/en

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

The invention provides novel substituted, bicyclic compounds which are useful as inhibitors of extra terminal domain BET protein function by binding to bromodomains. The pharmaceutical compositions comprising such compounds are for the prevention and treatment of diseases and conditions that are associated with bromodornain and extra terminal domain (BET) proteins.
PCT/US2014/043423 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors WO2015002754A2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
BR112015031073-7A BR112015031073B1 (en) 2013-06-21 2014-06-20 BICYCLIC BROMODIMANIUM INHIBITORS AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUNDS
DK14820520.6T DK3010503T3 (en) 2013-06-21 2014-06-20 New bicyclic bromodomain inhibitors
AU2014284616A AU2014284616B2 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
CN201480034817.9A CN105407888B (en) 2013-06-21 2014-06-20 New bicyclic bromine structural domain inhibitor
MX2015017045A MX365864B (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors.
PL14820520T PL3010503T3 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
EP14820520.6A EP3010503B1 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
SG11201510409QA SG11201510409QA (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
SI201431582T SI3010503T1 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
EP20154850.0A EP3674300B1 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
ES14820520T ES2806135T3 (en) 2013-06-21 2014-06-20 New bicyclic bromodomain inhibitors
EA201592143A EA035601B1 (en) 2013-06-21 2014-06-20 Bicyclic bromodomain inhibitors
CA2915838A CA2915838C (en) 2013-06-21 2014-06-20 Bicyclic bromodomain inhibitors
KR1020157035639A KR102307566B1 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
NZ714669A NZ714669A (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
JP2016521848A JP6461121B2 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors
IL242844A IL242844B (en) 2013-06-21 2015-11-30 Novel bicyclic bromodomain inhibitors
US14/977,508 US9663520B2 (en) 2013-06-21 2015-12-21 Bicyclic bromodomain inhibitors
ZA2016/00272A ZA201600272B (en) 2013-06-21 2016-01-13 Novel bicyclic bromodomain inhibitors
HK16104809.5A HK1216722A1 (en) 2013-06-21 2016-04-27 Novel bicyclic bromodomain inhibitors
HK16110599.6A HK1222335A1 (en) 2013-06-21 2016-09-06 Novel bicyclic bromodomain inhibitors
US15/486,256 US10010556B2 (en) 2013-06-21 2017-04-12 Bicyclic bromodomain inhibitors
US15/875,678 US10363257B2 (en) 2013-06-21 2018-01-19 Bicyclic bromodomain inhibitors
AU2019201212A AU2019201212C1 (en) 2013-06-21 2019-02-21 Novel bicyclic bromodomain inhibitors
US16/440,350 US10772892B2 (en) 2013-06-21 2019-06-13 Bicyclic bromodomain inhibitors
HRP20200854TT HRP20200854T1 (en) 2013-06-21 2020-05-27 Novel bicyclic bromodomain inhibitors
US16/940,785 US11446306B2 (en) 2013-06-21 2020-07-28 Bicyclic bromodomain inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361837841P 2013-06-21 2013-06-21
US61/837,841 2013-06-21

Related Child Applications (1)

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US14/977,508 Continuation US9663520B2 (en) 2013-06-21 2015-12-21 Bicyclic bromodomain inhibitors

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WO2015002754A3 true WO2015002754A3 (en) 2015-03-12

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US (5) US9663520B2 (en)
EP (2) EP3010503B1 (en)
JP (4) JP6461121B2 (en)
KR (1) KR102307566B1 (en)
CN (2) CN105407888B (en)
AU (2) AU2014284616B2 (en)
BR (1) BR112015031073B1 (en)
CA (2) CA3190653A1 (en)
DK (1) DK3010503T3 (en)
EA (1) EA035601B1 (en)
ES (1) ES2806135T3 (en)
HK (2) HK1216722A1 (en)
HR (1) HRP20200854T1 (en)
HU (1) HUE049469T2 (en)
IL (1) IL242844B (en)
MX (1) MX365864B (en)
NZ (2) NZ714669A (en)
PL (1) PL3010503T3 (en)
PT (1) PT3010503T (en)
SG (2) SG10201710705UA (en)
SI (1) SI3010503T1 (en)
WO (1) WO2015002754A2 (en)
ZA (2) ZA201600272B (en)

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