WO2014204417A1 - Dispositif d'inhalation comprenant une plaque flexible - Google Patents

Dispositif d'inhalation comprenant une plaque flexible Download PDF

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Publication number
WO2014204417A1
WO2014204417A1 PCT/TR2014/000200 TR2014000200W WO2014204417A1 WO 2014204417 A1 WO2014204417 A1 WO 2014204417A1 TR 2014000200 W TR2014000200 W TR 2014000200W WO 2014204417 A1 WO2014204417 A1 WO 2014204417A1
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WO
WIPO (PCT)
Prior art keywords
mouthpiece
upper cover
capsule
inhalation device
capsule chamber
Prior art date
Application number
PCT/TR2014/000200
Other languages
English (en)
Inventor
Mahmut Bilgic
Original Assignee
Mahmut Bilgic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahmut Bilgic filed Critical Mahmut Bilgic
Publication of WO2014204417A1 publication Critical patent/WO2014204417A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use

Definitions

  • the present invention relates to an inhalation device used for inhalation of medicaments in dry powder form from capsules.
  • a capsule which is loaded to the capsule chamber of the inhalation device prior to inhalation is pierced by means of at least one needle pushed towards the capsule chamber and the medicament in dry powder form comprised in the capsule becomes ready for inhalation once the patient presses the push button.
  • Dry powder inhalation devices are the devices used for inhalation of medicaments in dry powder form generally from capsules, blisters or reservoirs. Accordingly, dry powder inhalation devices can be either single-dose inhalers or multi-dose inhalers. While multi-dose inhalation devices are used in order to inhale the medicament in dry powder form from blisters or reservoirs, single-dose dry powder inhalation devices are used in order to inhale the medicament in dry powder form from capsules.
  • the inhalation devices which provide the medicament in dry powder form to be inhaled from capsule are commonly used for inhalation of the medicament in dry powder form.
  • the cover and the mouthpiece are opened generally by the patient rotating them respectively in order to expose the capsule chamber; a capsule is loaded to the capsule chamber and it is pierced by at least one needle moving towards the capsule chamber once an actuation button is pushed or rotated.
  • the medicament in dry powder form comprised in the pierced capsule becomes ready for inhalation.
  • the inhalation devices described in the patents explained below serve as examples for the inhalation devices having the aforementioned characteristic features.
  • EP 0703800 discloses an inhalation device having a bowl-shaped bottom-casing, a plate covering this bottom-casing and connecting with the capsule chamber, a mouthpiece and a cover protecting the mouthpiece. These components of the device are connected to each other by means of a hinge.
  • a hinge In order to place a capsule into the capsule chamber of the inhalation device, primarily the cover is rotated around the hinge until the mouthpiece is exposed; after the mouthpiece is exposed, the mouthpiece is rotated around the hinge until the capsule chamber is exposed.
  • a capsule comprising the medicament in dry powder form is placed into the capsule chamber which appears after the cover and the mouthpiece are rotated individually around the hinge.
  • the mouthpiece is closed over the plate which is connected to the capsule chamber and the capsule in the capsule chamber is pierced when the spring-loaded actuation button on the side-part of the device is pressed and the medicament in dry powder form comprised in the capsule becomes ready for inhalation.
  • US 7694676 discloses an inhalation device which comprises a bottom-casing wherein the capsule chamber is placed, a plate locked to the bottom-casing and providing the bottom-casing to be closed, a mouthpiece locked to the plate, a cover which hides the mouthpiece in closed position and is locked by means of a closure member.
  • These components are fixed to each other by means of a hinge similar to the device disclosed in the patent above.
  • the actuating button of this device was designed to be double-functional; in the first actuation, the closure member is detached from the bottom-casing and the cover becomes rotatable; in the second actuation, the capsule in the capsule chamber is pierced by means of the needles.
  • the closure member of the cover is released from the bottom-casing and the cover can be rotated manually by the patient.
  • the mouthpiece is also removed from the plate by being rotated in order to load the capsule into the capsule chamber.
  • the capsule is loaded to the capsule chamber which is exposed when the mouthpiece is rotated and the mouthpiece is again closed over the plate. In this position, the capsule in the capsule chamber is pierced by the second actuation of the actuating button and the medicament in dry powder form comprised in the capsule becomes ready for inhalation.
  • the aim of the present invention is to provide the inhalation devices in the prior art to be improved in terms of use which are used for inhalation of the medicament in dry powder form from capsules.
  • the aim of the present invention is to provide an inhalation device which is easy to use and practical, is prepared in a short time for inhalation of the medicament in dry powder form from capsule.
  • the present invention aims to provide an inhalation device wherein each dose is delivered entirely and accurately, the patients and relatives of the patients can be protected from possible accidents and misuses, and the safe inhalation shall be provided.
  • an inhalation device comprising,
  • a capsule chamber integrated with the mid-plate in order to place the capsule, a filter in order to filtrate dry powder formulation,
  • a hinge providing the connection between the upper cover, the mouthpiece, the mid-plate and the bottom-casing with each other
  • a movable push button in order to push at least one needle into the capsule chamber, a flexible plate preventing the movement of the mouthpiece and the upper cover in sleep mode of the device, characterized in that the flexible plate is connected with both the filter connector inserted into the mouthpiece and the upper cover, and this connection provides both the mouthpiece and the upper cover to be released together and simultaneously.
  • the main advantage of the present invention is that before loading a capsule into the capsule chamber, the mouthpiece and the upper cover are released simultaneously by actuating only the upper cover without implementing the processes separately in order to move the mouthpiece and the upper cover and these components become ready to be moved together by the patient.
  • the processes before loading a capsule into the capsule chamber can be implemented easily and in a short time in order to prepare the inhalation device for use.
  • the fact that the inhalation device becomes ready for use in a short time is of great importance for the patient during asthma attack.
  • connection of locking latches over the flexible plate to the upper cover and the mouthpiece in sleep mode of the device eliminates the possibility for opening of the device accidentally and makes the use of device safe.
  • the upper cover, the mouthpiece, the mid-plate and the bottom-casing of the device of the present invention are fixed to each other by a hinge and each of these components can be rotated around the same axis.
  • the devices of the present invention provide safe use since they prevent misuse and they also provide some important advantages in terms of ease of use thanks to this characteristic feature.
  • the force required for rotating the upper cover and the mouthpieces which are released by actuating the upper cover is considerably low, it is not needed for these components to use additional device parts which provide the patient to grip these components tightly. Since the upper cover and the mouthpiece do not have these parts, the appearance of the inhalation device is improved and these parts are prevented from accumulation of dirt.
  • the extensions under the upper cover and the extensions situated on both sides of the filter connector inserted into the mouthpiece insert into the bottom-casing when the inhalation device is closed.
  • one of the locking latches situated on the flexible plate is interlocked to the hole of an extension under the upper cover; the other one is interlocked to the hole of an extension belonging to the filter connector.
  • the inhalation device can have one flexible plate located on each of the two sides of the inhalation device which are situated oppositely.
  • the locking latches situated on these flexible plates can be interlocked to the holes of the extensions belonging to the mouthpiece and the upper cover which are located on the same side of the locking latches.
  • the upper cover should be actuated by being pressed by the patient in order to release the upper cover and the mouthpiece simultaneously.
  • the upper cover and the mouthpiece released by applying force to the upper cover and the mouthpiece by the flexible plate can be rotated together only up to 90°.
  • the mouthpiece cannot be rotated more than 90°; however the upper cover can be rotated by 180°.
  • the mouthpiece and the upper cover, which move together up to a position of 90° are separated by the continuing rotation of the upper cover after said position.
  • the structure of the hinge unit on the edge of the mouthpiece prevents the mouthpiece from rotating more than 90°.
  • This hinge element has a protruding structure in the manner that it prevents the movement of the mouthpiece more than 90°. After the mouthpiece is rotated by 90°, this protruding part leans on the bottom-casing and it prevents the rotation of the mouthpiece more than 90°.
  • the upper cover and the mouthpiece can be rotated together by 90° thanks to this connection between the mouthpiece and the upper cover.
  • the nails situated on the exterior surface of the mouthpiece are easily detached from the holes situated on the interior surface of the upper cover as the upper cover continues to rotate after the mouthpiece stops at this position and the upper cover and the mouthpiece are separated.
  • an air intake duct passing through the mouthpiece to provide the delivery of the dry powder medicament in the capsule to the patient.
  • One end of this air intake duct reaches to the mouthpiece inlet while the other end is inserted into the filter connector.
  • the point where the air intake duct ends in the filter connector is adjusted in such a way that the dry powder formulation sieved from the filter goes into the air intake duct without dispersing.
  • the filter connector is connected both to the holes On the side of the mouthpiece and the air intake duct passing through the mouthpiece.
  • the filter which provides to sieve the dry powder medicament comprised in the capsule during inhalation is also held by this filter connector.
  • the filter connector therefore the filter, is in a fixed position due to the connection of the filter connector with said components.
  • the mid-plate and the capsule chamber are preferably adjacent to each other and the capsule chamber is situated under the mid-plate.
  • the inhalation device of the present invention comprises a press button, preferably flexible plate, which is independent from the flexible plate and actuated when pressed.
  • the press button is preferably situated on the side part of the device and does not outreach the margins of the bottom-casing of the device.
  • the needle holder holding the needles piercing the capsule in the capsule chamber is in contact with the press button. Also the needles held by the needle holder are placed in the guide rails extending from the side-part of the capsule chamber. Upon pressing the press button, the needle holder moves towards the capsule chamber and the needles pierce the capsule in the capsule chamber moving through the guide rails.
  • the needle holder is connected to the mid-plate in the manner that it can easily move towards the capsule chamber and move away from the capsule chamber.
  • a holding member can be situated on a suitable part of the mid-plate which would facilitate holding for the patient. Thanks to this holding member, the mid-plate can be easily rotated.
  • a spring is situated between the capsule chamber and the needle holder in order to revert back the needles to their first positions after they pierce the capsule in the capsule chamber.
  • This spring is located on a connecting rod extending from the side-part of the capsule chamber towards the hole in the middle of the needle holder.
  • the connection rod appears from the side of the capsule chamber, enters into the hole in the center of the needle holder by passing through the spring.
  • the upper cover and the mouthpiece which are released simultaneously when the upper cover is actuated are rotated away from the mid-plate in order to load a capsule into the capsule chamber before inhalation.
  • the mouthpiece stops at 90° and the upper cover and the mouthpiece are separated from each other as the upper cover continues to be rotated.
  • the mouthpiece is again rotated over the mid-plate and the position of the mouthpiece is fixed once the locking latch on the upper part of the flexible plate is clasped into the hole of the extension belonging to the filter connector engaged into the mouthpiece.
  • the flexible plate is actuated pressing on the press button which is preferably situated independent from the flexible plate.
  • the needle holder which is in contact with the press button is pushed towards the capsule chamber as the press button is actuated. While the needle holder is pushed towards the capsule chamber by the push button to pierce the capsule, the needles carried by the needle holder proceeds through the guide rails extending towards one side of the capsule chamber and the capsule in the capsule chamber is pierced by these needles.
  • the dry powder formulation comprised in the capsule becomes ready for inhalation. After inhalation, the mouthpiece is released by applying force on it by the patient and the empty capsule is removed from the capsule chamber. When required, the device is cleaned by rotating the mid-plate around the hinge.
  • Figure 1 is a perspective view of the inhalation device in sleep mode
  • Figure 2a is front view of the upper cover
  • Figure 2b is rear view of the upper cover
  • Figure 3a and 3b are views of the parts within the bottom-casing when the device is in sleep mode
  • Figure 4a and Figure 4b are front and rear views of the mouthpiece, respectively
  • Figure 5a is to view of the mid-plate and the filter connector in assembled form
  • Figure 5a and Figure 5b are front and rear views of the mid-plate and the filter connector in assembled form, respectively
  • FIG. 6a and Figure 6b are different perspective views of the filter connector
  • Figure 7 is a perspective view of the filter
  • Figure 8 is a perspective view of the needle holder
  • FIG. 9a and Figure 9b are different perspective views of the flexible plate
  • Figure 10a and Figure 10b are different perspective views of the inner side of the bottom- casing
  • Figure 1 1 is a vertical section view of the device
  • Figure 1 shows a view of the inhalation device in sleep mode.
  • the inhalation device is in sleep mode, only the upper cover (1), the bottom-casing (4) and press button (9) can be seen.
  • the basic components of the device that are the upper cover (1), the mouthpiece (2), the mid-plate (3) and the bottom-casing (4) are connected to each other by means of a hinge (10). Thanks to the connection which is provided by the hinge (10) that goes into the hinge holes (la, 2a, 3 a, 4a) of these components, each component can be rotated easily around the hinge (10).
  • the flexible plate (8) When the device is in sleep mode, the flexible plate (8) is also in sleep mode. When the device is in sleep mode, the flexible plate (8) is connected to the upper cover (1) and the mouthpiece (2) in the manner that it prevents the rotation of the upper cover (1) and the mouthpiece (2) ( Figure 3a and Figure 3b).
  • the right locking latch (8a) of the locking latches on the flexible plate is interlocked to the hole of the front extension (lb) under the upper cover
  • the left locking latch (8b) is interlocked to the hole of the front extension (6c) under the filter connector which is internally interlocked to the mouthpiece (2) ( Figures 3a and 3b).
  • the other extensions (lc, 6d) of the upper cover (1) and the filter 1 connector (6) are not perforated since the flexible plate (8) is not interlocked to a locking latch ( Figure 2a, Figure 2b, Figure 6b).
  • the locking latches (8a, 8b) situated on the flexible plate (8) detach from the extensions (lb, 6c) of the filter connector (6) which is internally interlocked to the upper cover (1) and the mouthpiece, by this way, the upper cover and the mouthpiece are released simultaneously.
  • Pressing on the upper cover (1) to activate it by the patient causes the simultaneous release of the upper cover (1) and the mouthpiece (2) and enables these two components to synchronize.
  • the locking latches (6a, 6b) situated on the filter connector go into the holes on the locking points (2b, 2c) situated on the side of the mouthpiece (2) and provide the filter connector (6) to be interlocked internally to the mouthpiece (2) ( Figures 6a and 6b). Clasping of the locking latches (6a, 6b) on the upper part of the filter connector into the holes on the interlocking points (2b, 2c) on the sides of the mouthpiece (2) causes formation of nails on these interlocking points (2b, 2c) on the outer surface of the mouthpiece. The nail on the first interlocking point on the side of the mouthpiece goes into the front hole (Id) on the interior surface of the upper cover. The nail on the second interlocking point is shown in Figure 2.
  • the hinge hole (2a) of the mouthpiece has a protruding structure that does not allow the mouthpiece to be rotated more than 90° ( Figure 4a and Figure 4b).
  • This protruding part (2e) leans on the bottom-casing (4) after the mouthpiece is rotated by 90° and does not allow the mouthpiece (2) to be rotated more than 90°. If the upper cover (1), which is rotated by 90° together with the mouthpiece (2), is continued to be rotated after the mouthpiece (2) stops at 90°, the upper cover (1) and the mouthpiece (2) are separated from each other as the nails situated on the exterior surface of the mouthpiece (2) detach from the hole (Id) situated on the internal surface of the upper cover (1) easily.
  • the upper cover (1) can be rotated only by 180°.
  • the angle between them can be maximum 90° when the upper cover (1) and the mouthpiece (2) are separated from each other.
  • the flexible plate (8) is released and becomes ready to interlock to the front extension on the upper cover (lb) and the front extension on the filter connector (6c).
  • the mouthpiece (2) is rotated again over the mid- plate (3) in order to realize inhalation and the mouthpiece is connected to the flexible plate (8) again by interlocking of the left locking latch (8b) on the flexible plate (8) to the hole of the front extension (6c) under the filter connector and the mouthpiece (2) is fixed for a safe inhalation.
  • a press button (9) which is independent from the flexible plate (8) is actuated pressing on it by the patient.
  • the press button (9) is in sleep mode ( Figure 1), it is in contact with the needle holder (12) holding the needles (12b, 12c); and the needles (12b, 12c) held by the needle holder (12) are situated into the guide rails (1 1a, l ib) extending towards the side of the capsule chamber (11) ( Figure 12).
  • the needles (12b, 12c) enter the capsule chamber (11) by moving through the guide rails (11a, l ib) and pierce the capsule in the capsule chamber (1 1).
  • Two needles (12b, 12c) are held by the needle holder (12) in order to pierce the capsule.
  • the press button (9) is pressed in order to pierce the capsule, the upper needle (12b) moves through the upper guide rail (11a), the lower needle (12c) moves through the lower guide rail (l ib) upon the movement of the needle holder (12) towards the capsule chamber (11) and they pierce the capsule in the capsule chamber (1 1).
  • the needles (12b, 12c) revert back to their first positions after piercing the capsule and this is provided by means of a spring (13) ( Figure 12).
  • This spring (13) is situated between the capsule chamber (11) and the needle holder (12).
  • a connection rod (1 lc) reaching towards the hole (12a) in the center of the needle holder (12) from the side of the capsule chamber (1 1) passes through this spring ( Figure 12).
  • the press button (9) Upon pressing the press button (9), while the needle holder (12) moves towards the capsule chamber, the connection rod (11c) moves through the hole (12a) in the center of the needle holder and the spring (13) is compressed.
  • the press button (9) is released while the spring (13) reverts back to its previous position, the needle holder (12) and therefore the needles (12b, 12c) revert back to their first positions.
  • An air intake duct (5) is inserted into the mouthpiece (2) in order to provide the delivery of the medicament in dry powder form comprised in the capsule to the patient during inhalation ( Figure 12).
  • One end of this air intake duct (5) reaches to the inlet of the mouthpiece (2); the other end goes into the filter connector (6).
  • the filter connector (6) is connected both to the interlocking points (2b, 2c) on the side part of the mouthpiece (2) and the air intake duct (5) inserted into the mouthpiece (2), it is fixed to the mouthpiece (2).
  • the filter (7) showed in Figure 7 and providing the medicament in dry powder form comprised in the capsule to be sieved is held by the filter connector (6) showed in Figure 6a and 6b.
  • the medicament in dry powder form in the capsule pierced is delivered to the patient by means of the mouthpiece after passing through the filter (7), the filter connector (6) and the air intake duct (5).
  • the medicament in dry powder form comprised in the capsule becomes ready for inhalation.
  • the mouthpiece (8) is pressed in order to reactuate it after the inhalation of the medicament in dry powder form, the front extension (6c) of the filter connector is detached from the left locking latch (8b) of the flexible plate and released. In this position, the mouthpiece (2) can be rotated away from the mid-plate (3) again and the empty capsule in the capsule chamber (1 1) can be removed.
  • the mid-plate (3) can be rotated around the hinge (10) away from the bottom-casing by holding the holding member (3b) situated on the mid- plate and by this way the bottom-casing (4) can be cleaned easily.
  • the upper cover (1) and the mouthpiece (2) which are released simultaneously when the flexible plate (8) is actuated are rotated together away from the mid-plate (3) in order to load a capsule into the capsule chamber (11) before inhalation.
  • the capsule is loaded to the capsule chamber (11)
  • the mouthpiece (2) is rotated over the mid-plate (3) again and the position of the mouthpiece (2) is fixed by interlocking the left locking latch (8b) on the flexible plate (8) to the hole of the front extension (6c) belonging to the filter connector which is internally interlocked to the mouthpiece.
  • the press button (9) which is situated independent from the flexible plate (8) is actuated when the patient presses on it.
  • the needle holder (12) which is in contact with the press button (9) is pushed towards the capsule chamber (11) as the press button (9) is actuated.
  • the spring (13) between the capsule chamber (11) and needle holder (12) is compressed, the needles (12b, 12c) carried by the needle holder (12) move through the guide rails (11a, 1 lb) extending towards the side of the capsule chamber (11) and the capsule in the capsule chamber (11) are pierced by these needles (12b, 12c).
  • the spring (13) reverts back to its old position, the needles (12b, 12c) also revert back to their first positions as the press button is released.
  • the dry powder formulation comprised in the capsule becomes ready for inhalation.
  • the medicament in dry powder form in the pierced capsule exits the capsule chamber (11), it is delivered to the patient by means of the mouthpiece (2) after passing through the filter (7), filter connector (6) and air intake duct (5).
  • the inhalation device of the present invention comprising capsule can be made of the same or different materials.
  • each component of the inhalation device can be made of any suitable material, though it is preferably selected from a group comprising styrene, acrylonitrile, polyoxymethylene, acrylic polymethyl methacrylate, cellulose acetate, polyetheretherketone, polyvinyl chloride, polyethylene, polypropylene, acrylonitrile butadiene styrene, silicon, polycarbonate, polyamide, polystyrene, polyurethane or fluoropolymer types.
  • each component of the device can be in any suitable color.
  • the capsule used in the inhalation device comprising capsules according to the present invention can be made of any suitable component, though it is preferably made of a material selected from a group comprising gelatin, chitosan, starch and/or starch derivatives, cellulose and/or cellulose derivatives or synthetic polymers.
  • the capsule of the present invention is composed of intertwining top and bottom parts. The top and the bottom parts of said capsule can be made of identical or different materials.
  • the capsule material can be selected from, but not limited to, a group comprising hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose.
  • the capsule material can be selected from, but not limited to, a group comprising polyethylene, polyester, polyethylenterephthalat, polycarbonate or polypropylene.
  • the capsule material that shall be used in the present invention is gelatin, additional agents having different molecular weights such as polyethylene glycol, sorbitol, glycerol, propylene glycol, polyethylene oxide-polypropylene oxide block copolymers and/or other polyalcohols and polyethers can be used.
  • the capsule which is used in the inhalation device of the present invention and wherein the medicament in dry powder form is carried can be in any suitable form and color on the condition that the medicament has the aforementioned characteristic features.
  • the capsule wherein the medicament in dry powder form is carried in the inhalation device of the present invention which is illustrated in the drawings elucidated above is produced according to the prior art.
  • the particle sizes of the active agents comprised in the medicament in dry powder form contained in the capsule are less than 10 ⁇ , preferably less than 5 ⁇ .
  • the inhalation device of the present invention has been designed so as to administer the medicament in dry powder form used in monotherapy or combined therapy.
  • monotherapy refers to inhalation treatment wherein the medicament in dry powder form comprising a single active agent is used whereas the term “combined therapy” refers to inhalation treatment wherein the medicament in dry powder form comprising more than one active agent is used.
  • the medicament in dry powder form administered by means of the device of the present invention comprises at least one excipient in addition to the active agent or agents.
  • excipients are generally chosen from a group comprising monosaccharides (glucose, arabinose, etc.), disaccharides (lactose, saccharose, maltose, etc.), oligo- and polysaccharides (dextran, etc.), polyalcohols (sorbite, mannite, xylite), salts (sodium chloride, calcium carbonate, etc.) or combinations thereof.
  • the medicament in dry powder form preferably comprises lactose as the excipient.
  • the medicament in dry powder form comprises fine or coarse excipient particles preferably having various particle size ranges in order to transmit the required amount to the lungs.
  • the active agent or active agents comprised in the dry powder medicament which is stored in capsules used in the device according to the present invention can be selected from a group comprising cromolyns, anti-infectives, antihistamines, steroids, anti- inflammatory, bronchodilators, leukotriene inhibitors, PDE IV inhibitors, antitussives, diuretics, anticholinergics, hormones, xanthines and pharmaceutically acceptable derivatives thereof.
  • the active agent comprised in the medicament in dry powder form delivered via the inhalation device according to the present invention is preferably selected from a group comprising tiotropium, oxitropium, flutropium, ipratropium, glycopyrronium, flunisolide, beclomethasone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide, dexamethasone, montelukast, methylcyclopropane acetic acid, sodium cromoglycate, nedocromil sodium, enprofylline, theophylline, rofiumilast, ariflo (cilomilast), salmeterol, salbutamol, formoterol, terbutaline, carmoterol, indacaterol, cetirizine, levocetirizine, efletirizine, fexofenadine and racemates, free base, enantiomers or diastereomers and
  • the device according to the present invention is used in administration of the medicament in dry powder form which is used in treatment of many respiratory diseases, particularly in asthma, chronic obstructive pulmonary disease (COPD) and allergic rhinitis.
  • the respiratory tract diseases comprise, but not limited to, allergic or non-allergic asthma at any phases, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), exacerbation of airways hyperactivity, bronchiectasis, chronic obstructive pulmonary including emphysema and chronic bronchitis, airways or lung diseases (COPD, COAD or COLD), pneumoconiosis, aluminosis, anthracosis, asbestosis, chalicosis, ptilosis, siderosis, silicosis, tabacosis and byssinosis.
  • the device of the present invention can be used in prophylactic or symptomatic treatment.
  • the medicament in dry powder form which is preferably used in the symptomatic treatment of

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Abstract

La présente invention concerne un dispositif d'inhalation utilisé pour l'inhalation de médicaments sous la forme de poudre sèche à partir de capsules.
PCT/TR2014/000200 2013-06-19 2014-05-26 Dispositif d'inhalation comprenant une plaque flexible WO2014204417A1 (fr)

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TR2013/07401 2013-06-19

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017005420A1 (fr) * 2015-07-03 2017-01-12 Iconovo Ab Inhalateur à poudre sèche
WO2018001095A1 (fr) * 2016-07-01 2018-01-04 Cai Gu Huang Dispositif inhalateur pour administrer des compositions pharmaceutiques en poudre par inhalation
USD852408S1 (en) 2016-02-08 2019-06-25 Nicoventures Holdings Limited Electronic cigarette
US11123501B2 (en) 2016-03-24 2021-09-21 Nicoventures Holdings Limited Electronic vapor provision system
US11213638B2 (en) 2016-03-24 2022-01-04 Nicoventures Trading Limited Vapor provision system
US11241043B2 (en) 2016-03-24 2022-02-08 Nicoventures Trading Limited Vapor provision apparatus
US11452826B2 (en) 2016-03-24 2022-09-27 Nicoventures Trading Limited Mechanical connector for electronic vapor provision system
US11524823B2 (en) 2016-07-22 2022-12-13 Nicoventures Trading Limited Case for a vapor provision device
WO2023038607A1 (fr) * 2021-09-13 2023-03-16 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalateur de poudre sèche automatique

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US5657749A (en) * 1992-09-11 1997-08-19 Glaxo Group Limited Inhalation device
CA2544745A1 (fr) * 2003-11-08 2005-05-19 Boehringer Ingelheim International Gmbh Inhalateur de poudre
WO2011133740A1 (fr) * 2010-04-23 2011-10-27 Cambridge Consultants Limited Ensemble et contenants d'inhalateurs à poudre sèche
WO2011149435A1 (fr) * 2010-05-28 2011-12-01 Mahmut Bilgic Inhalateur de poudre
WO2012047181A1 (fr) * 2010-10-07 2012-04-12 Mahmut Bilgic Inhalateur comprenant une capsule
WO2013095311A1 (fr) * 2011-11-25 2013-06-27 Mahmut Bilgic Dispositif d'inhalation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5657749A (en) * 1992-09-11 1997-08-19 Glaxo Group Limited Inhalation device
CA2544745A1 (fr) * 2003-11-08 2005-05-19 Boehringer Ingelheim International Gmbh Inhalateur de poudre
WO2011133740A1 (fr) * 2010-04-23 2011-10-27 Cambridge Consultants Limited Ensemble et contenants d'inhalateurs à poudre sèche
WO2011149435A1 (fr) * 2010-05-28 2011-12-01 Mahmut Bilgic Inhalateur de poudre
WO2012047181A1 (fr) * 2010-10-07 2012-04-12 Mahmut Bilgic Inhalateur comprenant une capsule
WO2013095311A1 (fr) * 2011-11-25 2013-06-27 Mahmut Bilgic Dispositif d'inhalation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017005420A1 (fr) * 2015-07-03 2017-01-12 Iconovo Ab Inhalateur à poudre sèche
USD852408S1 (en) 2016-02-08 2019-06-25 Nicoventures Holdings Limited Electronic cigarette
US11123501B2 (en) 2016-03-24 2021-09-21 Nicoventures Holdings Limited Electronic vapor provision system
US11213638B2 (en) 2016-03-24 2022-01-04 Nicoventures Trading Limited Vapor provision system
US11241043B2 (en) 2016-03-24 2022-02-08 Nicoventures Trading Limited Vapor provision apparatus
US11452826B2 (en) 2016-03-24 2022-09-27 Nicoventures Trading Limited Mechanical connector for electronic vapor provision system
WO2018001095A1 (fr) * 2016-07-01 2018-01-04 Cai Gu Huang Dispositif inhalateur pour administrer des compositions pharmaceutiques en poudre par inhalation
US11524823B2 (en) 2016-07-22 2022-12-13 Nicoventures Trading Limited Case for a vapor provision device
WO2023038607A1 (fr) * 2021-09-13 2023-03-16 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalateur de poudre sèche automatique

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