WO2014195965A3 - An improved process for the preparation of hmg-coa reductase inhibitor intermediates - Google Patents
An improved process for the preparation of hmg-coa reductase inhibitor intermediates Download PDFInfo
- Publication number
- WO2014195965A3 WO2014195965A3 PCT/IN2014/000356 IN2014000356W WO2014195965A3 WO 2014195965 A3 WO2014195965 A3 WO 2014195965A3 IN 2014000356 W IN2014000356 W IN 2014000356W WO 2014195965 A3 WO2014195965 A3 WO 2014195965A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- formula
- preparation
- hmg
- coa reductase
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 9
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- ZSXGLVDWWRXATF-UHFFFAOYSA-N N,N-dimethylformamide dimethyl acetal Chemical compound COC(OC)N(C)C ZSXGLVDWWRXATF-UHFFFAOYSA-N 0.000 abstract 1
- -1 alkyl chloroformate Chemical compound 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to novel processes for the preparation of compounds of Formula-II useful as intermediates in preparation of HMG-CoA reductase inhibitors, and further conversion of said intermediates to HMG-CoA reductase inhibitors. The process for the preparation of compounds of Formula-II comprises reacting compounds of Formula-Ill with dimethylformamide dimethylacetal in the presence of a base to get compounds of Formula-IV, reacting the compounds of formula-IV with alkyl chloroformate in the presence of a base to get compounds of Formula-V, and converting the compounds of Formula-V into compounds of Formula-II. The compounds have the following structures, [Formulas should be inserted here] wherein X is hydrogen or hydroxy protecting group, R1 is carboxyl protecting group, Alk represents C1-C4 alkyl and R2, R3 and R4 are independently selected from substituted or unsubstituted C6-C10 aryl groups.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2291/CHE/2013 | 2013-05-27 | ||
| IN2291CH2013 | 2013-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2014195965A2 WO2014195965A2 (en) | 2014-12-11 |
| WO2014195965A3 true WO2014195965A3 (en) | 2015-04-30 |
Family
ID=51417544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2014/000356 WO2014195965A2 (en) | 2013-05-27 | 2014-05-26 | An improved process for the preparation of hmg-coa reductase inhibitor intermediates |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2014195965A2 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011141934A1 (en) * | 2010-05-13 | 2011-11-17 | Matrix Laboratories Ltd. | An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors |
| WO2013080219A2 (en) * | 2011-11-28 | 2013-06-06 | Mylan Laboratories Ltd | NOVEL PROCESS FOR THE PREPARATION OF INTERMEDIATES OF HMG-CoA REDUCTASE INHIBITORS |
-
2014
- 2014-05-26 WO PCT/IN2014/000356 patent/WO2014195965A2/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011141934A1 (en) * | 2010-05-13 | 2011-11-17 | Matrix Laboratories Ltd. | An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors |
| WO2013080219A2 (en) * | 2011-11-28 | 2013-06-06 | Mylan Laboratories Ltd | NOVEL PROCESS FOR THE PREPARATION OF INTERMEDIATES OF HMG-CoA REDUCTASE INHIBITORS |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014195965A2 (en) | 2014-12-11 |
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