WO2014194030A3 - Conjugates comprising cell-binding agents and cytotoxic agents - Google Patents
Conjugates comprising cell-binding agents and cytotoxic agents Download PDFInfo
- Publication number
- WO2014194030A3 WO2014194030A3 PCT/US2014/039919 US2014039919W WO2014194030A3 WO 2014194030 A3 WO2014194030 A3 WO 2014194030A3 US 2014039919 W US2014039919 W US 2014039919W WO 2014194030 A3 WO2014194030 A3 WO 2014194030A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugates
- cell
- cytotoxic
- agents
- cba
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a branched linker compound with reactive moieties for forming covalent bonds with multiple cytotoxic agents (drugs) and/or a cell-binding agent (CBA); a cytotoxic compound comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; a modified cell-binding agent comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361829893P | 2013-05-31 | 2013-05-31 | |
US61/829,893 | 2013-05-31 |
Publications (2)
Publication Number | Publication Date |
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WO2014194030A2 WO2014194030A2 (en) | 2014-12-04 |
WO2014194030A3 true WO2014194030A3 (en) | 2015-01-22 |
Family
ID=50983218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/039919 WO2014194030A2 (en) | 2013-05-31 | 2014-05-29 | Conjugates comprising cell-binding agents and cytotoxic agents |
Country Status (1)
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WO (1) | WO2014194030A2 (en) |
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MX2015011348A (en) | 2013-03-15 | 2016-01-15 | Regeneron Pharma | Biologically active molecules, conjugates thereof, and therapeutic uses. |
CN105530942B (en) | 2013-08-26 | 2019-10-11 | 瑞泽恩制药公司 | A kind of pharmaceutical composition comprising macrolides diastereomer, preparation method and use |
KR101628872B1 (en) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | Compounds comprising self-immolative group |
CN106267225B (en) * | 2015-05-29 | 2020-03-06 | 上海新理念生物医药科技有限公司 | Trimaleimide-type linker and use thereof |
EP3308801A4 (en) | 2015-06-09 | 2019-02-27 | XDCExplorer (Shanghai) Co., Ltd. | Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof |
CN113599533A (en) | 2015-11-25 | 2021-11-05 | 乐高化学生物科学股份有限公司 | Antibody-drug conjugates comprising branched linkers and methods related thereto |
KR20180079452A (en) | 2015-11-25 | 2018-07-10 | 주식회사 레고켐 바이오사이언스 | Conjugates comprising self-sacrificial groups and methods for their preparation |
WO2017089894A1 (en) * | 2015-11-25 | 2017-06-01 | Legochem Biosciences, Inc. | Conjugates comprising peptide groups and methods related thereto |
CN114478801A (en) | 2016-01-25 | 2022-05-13 | 里珍纳龙药品有限公司 | Maytansinoid derivatives, conjugates thereof, and methods of use |
BR112019020136A2 (en) | 2017-03-29 | 2020-04-22 | Legochem Biosciences Inc | prodrug of pyrrolobenzodiazepine dimer and compound of ligand-ligand conjugate of the same |
AU2019266406A1 (en) | 2018-05-09 | 2020-11-26 | Legochem Biosciences, Inc. | Compositions and methods related to anti-CD19 antibody drug conjugates |
KR20210028544A (en) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | Antibody-drug conjugate comprising antibody binding to antibody against human ROR1 and its use |
KR102465431B1 (en) * | 2020-10-21 | 2022-11-09 | 순천향대학교 산학협력단 | Cell Penetrating Peptide-linker-anti-cancer drug and Pharmaceutical composition for prevention or treatment of colorectal cancer containing the same |
WO2022262516A1 (en) * | 2021-06-18 | 2022-12-22 | 北京海步医药科技有限公司 | Linker and conjugate therefor |
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