WO2014188011A3 - Method for preparation of linaclotide - Google Patents

Method for preparation of linaclotide Download PDF

Info

Publication number
WO2014188011A3
WO2014188011A3 PCT/EP2014/070577 EP2014070577W WO2014188011A3 WO 2014188011 A3 WO2014188011 A3 WO 2014188011A3 EP 2014070577 W EP2014070577 W EP 2014070577W WO 2014188011 A3 WO2014188011 A3 WO 2014188011A3
Authority
WO
WIPO (PCT)
Prior art keywords
linaclotide
preparation
cas
discloses
solid phase
Prior art date
Application number
PCT/EP2014/070577
Other languages
French (fr)
Other versions
WO2014188011A2 (en
Inventor
Ulf ALTENHOENER
Original Assignee
Ironwood Pharmaceuticals, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals, Inc filed Critical Ironwood Pharmaceuticals, Inc
Priority to PCT/EP2014/070577 priority Critical patent/WO2014188011A2/en
Publication of WO2014188011A2 publication Critical patent/WO2014188011A2/en
Publication of WO2014188011A3 publication Critical patent/WO2014188011A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention discloses a method for the preparation of linaclotide with CAS 851199-59-2 with solid phase peptide synthesis.
PCT/EP2014/070577 2014-09-25 2014-09-25 Method for preparation of linaclotide WO2014188011A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/070577 WO2014188011A2 (en) 2014-09-25 2014-09-25 Method for preparation of linaclotide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/070577 WO2014188011A2 (en) 2014-09-25 2014-09-25 Method for preparation of linaclotide

Publications (2)

Publication Number Publication Date
WO2014188011A2 WO2014188011A2 (en) 2014-11-27
WO2014188011A3 true WO2014188011A3 (en) 2015-04-16

Family

ID=51659619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/070577 WO2014188011A2 (en) 2014-09-25 2014-09-25 Method for preparation of linaclotide

Country Status (1)

Country Link
WO (1) WO2014188011A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11572386B2 (en) 2014-09-08 2023-02-07 Auro Peptides Ltd. Process for the preparation of linaclotide
ES2974095T3 (en) 2015-07-01 2024-06-25 Novetide Ltd Solid State Forms of Linaclotide
EP3411386A1 (en) * 2016-02-03 2018-12-12 Cipla Limited A process for the preparation of guanylate cyclase 2c agonist
JP7476798B2 (en) 2018-11-16 2024-05-01 味の素株式会社 Method for producing cyclized peptide having intramolecular S-S bond
CN111499693B (en) * 2020-04-27 2023-05-12 汉肽生物医药集团有限公司 Method for preparing linaclotide by solid-liquid combination
EP4194464A1 (en) 2021-12-13 2023-06-14 Chemi SPA Manufacturing process for the production of linaclotide
CN113956333B (en) * 2021-12-22 2022-03-29 浙江湃肽生物有限公司南京分公司 Synthesis and purification method of linaclotide
WO2023144292A1 (en) 2022-01-28 2023-08-03 Fresenius Kabi Ipsum S.R.L. Process for the preparation of linaclotide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100261877A1 (en) * 2009-04-10 2010-10-14 Michael Paul Fleming Process for isolating therapeutic peptides
CN102875655A (en) * 2012-09-29 2013-01-16 深圳翰宇药业股份有限公司 Linaclotide synthesis method
CN103626849A (en) * 2013-11-27 2014-03-12 深圳翰宇药业股份有限公司 Method for preparing linaclotide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100261877A1 (en) * 2009-04-10 2010-10-14 Michael Paul Fleming Process for isolating therapeutic peptides
CN102875655A (en) * 2012-09-29 2013-01-16 深圳翰宇药业股份有限公司 Linaclotide synthesis method
CN103626849A (en) * 2013-11-27 2014-03-12 深圳翰宇药业股份有限公司 Method for preparing linaclotide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIRIAM GÓNGORA-BENÍTEZ ET AL: "Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide", BIOPOLYMERS, vol. 96, no. 1, 1 January 2011 (2011-01-01), pages 69 - 80, XP055047758, ISSN: 0006-3525, DOI: 10.1002/bip.21480 *

Also Published As

Publication number Publication date
WO2014188011A2 (en) 2014-11-27

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