WO2014184807A3 - PROCESS FOR THE PREPARATION OF (2α,5β,7β,10β,13α)-4-ACETOXY-13-({(2R,3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-2-HYDROXY-3-PHENYLPROPANOYL}OXY)-1-HYDROXY-7,10-DIMETHOXY-9-OXO-5,20-EPOXYTAX-11-EN-2-YL BENZOATE - Google Patents

PROCESS FOR THE PREPARATION OF (2α,5β,7β,10β,13α)-4-ACETOXY-13-({(2R,3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-2-HYDROXY-3-PHENYLPROPANOYL}OXY)-1-HYDROXY-7,10-DIMETHOXY-9-OXO-5,20-EPOXYTAX-11-EN-2-YL BENZOATE Download PDF

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Publication number
WO2014184807A3
WO2014184807A3 PCT/IN2014/000326 IN2014000326W WO2014184807A3 WO 2014184807 A3 WO2014184807 A3 WO 2014184807A3 IN 2014000326 W IN2014000326 W IN 2014000326W WO 2014184807 A3 WO2014184807 A3 WO 2014184807A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
epoxytax
phenylpropanoyl
acetoxy
butoxycarbonyl
Prior art date
Application number
PCT/IN2014/000326
Other languages
French (fr)
Other versions
WO2014184807A2 (en
Inventor
Srinivasan Thirumalai Rajan
Muppa Kishore Kumar
Nimmala SRINIVAS RAO
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Publication of WO2014184807A2 publication Critical patent/WO2014184807A2/en
Publication of WO2014184807A3 publication Critical patent/WO2014184807A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for the preparation of (2α,5β,7β,10β,13α)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate compound of formula-1 and intermediates thereof.
PCT/IN2014/000326 2013-05-13 2014-05-12 PROCESS FOR THE PREPARATION OF (2α,5β,7β,10β,13α)-4-ACETOXY-13-({(2R,3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-2-HYDROXY-3-PHENYLPROPANOYL}OXY)-1-HYDROXY-7,10-DIMETHOXY-9-OXO-5,20-EPOXYTAX-11-EN-2-YL BENZOATE WO2014184807A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2112/CHE/2013 2013-05-13
IN2112CH2013 2013-05-13
IN3070/CHE/2013 2013-07-09
IN3070CH2013 2013-07-09

Publications (2)

Publication Number Publication Date
WO2014184807A2 WO2014184807A2 (en) 2014-11-20
WO2014184807A3 true WO2014184807A3 (en) 2015-02-26

Family

ID=51898946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000326 WO2014184807A2 (en) 2013-05-13 2014-05-12 PROCESS FOR THE PREPARATION OF (2α,5β,7β,10β,13α)-4-ACETOXY-13-({(2R,3S)-3-[(TERT-BUTOXYCARBONYL)AMINO]-2-HYDROXY-3-PHENYLPROPANOYL}OXY)-1-HYDROXY-7,10-DIMETHOXY-9-OXO-5,20-EPOXYTAX-11-EN-2-YL BENZOATE

Country Status (1)

Country Link
WO (1) WO2014184807A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110078686A (en) * 2019-04-28 2019-08-02 云南汉德生物技术有限公司 The method of 10- deacetylate Bakating III synthesis Cabazitaxel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102516281A (en) * 2011-10-20 2012-06-27 江苏红豆杉生物科技有限公司 10-deacetylbaccatin III and method for methoxylation of its derivative
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
US20130116444A1 (en) * 2011-10-31 2013-05-09 Scinopharm Taiwan, Ltd. Process for cabazitaxel, and intermediates thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN102516281A (en) * 2011-10-20 2012-06-27 江苏红豆杉生物科技有限公司 10-deacetylbaccatin III and method for methoxylation of its derivative
US20130116444A1 (en) * 2011-10-31 2013-05-09 Scinopharm Taiwan, Ltd. Process for cabazitaxel, and intermediates thereof

Also Published As

Publication number Publication date
WO2014184807A2 (en) 2014-11-20

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