WO2014184684A3 - Methods and biomarkers for detection of hematological cancers - Google Patents
Methods and biomarkers for detection of hematological cancers Download PDFInfo
- Publication number
- WO2014184684A3 WO2014184684A3 PCT/IB2014/001733 IB2014001733W WO2014184684A3 WO 2014184684 A3 WO2014184684 A3 WO 2014184684A3 IB 2014001733 W IB2014001733 W IB 2014001733W WO 2014184684 A3 WO2014184684 A3 WO 2014184684A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biomarkers
- samples
- detection
- methods
- hematological cancers
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of hematological cancers (e.g., lymphoma) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361824278P | 2013-05-16 | 2013-05-16 | |
US61/824,278 | 2013-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014184684A2 WO2014184684A2 (en) | 2014-11-20 |
WO2014184684A3 true WO2014184684A3 (en) | 2015-05-21 |
Family
ID=51585136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2014/001733 WO2014184684A2 (en) | 2013-05-16 | 2014-05-15 | Methods and biomarkers for detection of hematological cancers |
Country Status (1)
Country | Link |
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WO (1) | WO2014184684A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
CA3127894A1 (en) * | 2019-02-05 | 2020-08-13 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007050706A2 (en) * | 2005-10-27 | 2007-05-03 | University Of Missouri-Columbia | Dna methylation biomarkers in lymphoid and hematopoietic malignancies |
US20100273151A1 (en) * | 2004-05-28 | 2010-10-28 | Fred Hutchinson Cancer Research Center | Genome-wide analysis of palindrome formation and dna methylation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
AU2004270220B2 (en) | 2003-09-05 | 2009-03-05 | The Chinese University Of Hong Kong | Method for non-invasive prenatal diagnosis |
PT2385143T (en) | 2006-02-02 | 2016-10-18 | Univ Leland Stanford Junior | Non-invasive fetal genetic screening by digital analysis |
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2014
- 2014-05-15 WO PCT/IB2014/001733 patent/WO2014184684A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100273151A1 (en) * | 2004-05-28 | 2010-10-28 | Fred Hutchinson Cancer Research Center | Genome-wide analysis of palindrome formation and dna methylation |
WO2007050706A2 (en) * | 2005-10-27 | 2007-05-03 | University Of Missouri-Columbia | Dna methylation biomarkers in lymphoid and hematopoietic malignancies |
Non-Patent Citations (6)
Title |
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GARNIS CATHIE ET AL: "Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas", ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 23, no. 14, 1 April 2004 (2004-04-01), pages 2582 - 2586, XP002500728, ISSN: 0950-9232, DOI: 10.1038/SJ.ONC.1207367 * |
M. DAIBATA ET AL: "Promoter Hypermethylation of the Bone Morphogenetic Protein-6 Gene in Malignant Lymphoma", CLINICAL CANCER RESEARCH, vol. 13, no. 12, 15 June 2007 (2007-06-15), pages 3528 - 3535, XP055157346, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-06-2766 * |
R. SHAKNOVICH ET AL: "DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma", BLOOD, vol. 116, no. 20, 7 July 2010 (2010-07-07), pages e81 - e89, XP055158085, ISSN: 0006-4971, DOI: 10.1182/blood-2010-05-285320 * |
SMELAND: "Epigenetic mechanisms in the development of malignant lymphoma - Centre for Cancer Biomedicine", 10 February 2012 (2012-02-10), XP055156533, Retrieved from the Internet <URL:http://www.med.uio.no/ccb/english/research/groups/erlend-smeland/projects-smeland/epigenetic-mechanisms-in-the-development-of-malignant-lymphoma/> [retrieved on 20141203] * |
UCCELLA S ET AL: "MGMT methylation in diffuse large B-cell lymphoma: validation of quantitative methylation-specific PCR and comparison with MGMT protein expression", JOURNAL OF CLINICAL PATHOLOGY, BMJ PUBLISHING GROUP, GB, vol. 62, no. 8, 1 August 2009 (2009-08-01), pages 715 - 723, XP008173783, ISSN: 0021-9746, DOI: 10.1136/JCP.2009.064741 * |
ZHAOHUI WANG ET AL: "Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 11 October 2012 (2012-10-11), pages 209, XP021134187, ISSN: 1479-5876, DOI: 10.1186/1479-5876-10-209 * |
Also Published As
Publication number | Publication date |
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WO2014184684A2 (en) | 2014-11-20 |
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