WO2014184248A3 - Trpa1 antagonist compounds - Google Patents

Trpa1 antagonist compounds Download PDF

Info

Publication number
WO2014184248A3
WO2014184248A3 PCT/EP2014/059853 EP2014059853W WO2014184248A3 WO 2014184248 A3 WO2014184248 A3 WO 2014184248A3 EP 2014059853 W EP2014059853 W EP 2014059853W WO 2014184248 A3 WO2014184248 A3 WO 2014184248A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist compounds
trpa1 antagonist
compounds
trpa1
diastereomers
Prior art date
Application number
PCT/EP2014/059853
Other languages
French (fr)
Other versions
WO2014184248A2 (en
Inventor
Mats A SVENSSON
Dirk Weigelt
Original Assignee
Acturum Life Science AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acturum Life Science AB filed Critical Acturum Life Science AB
Publication of WO2014184248A2 publication Critical patent/WO2014184248A2/en
Publication of WO2014184248A3 publication Critical patent/WO2014184248A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compounds of Formula (I), pharmaceutically acceptable salts thereof, diastereomers, enantiomers, or mixtures thereof: wherein R1, R2, R3, X, Yn and A are as defined in the specification, as well as pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
PCT/EP2014/059853 2013-05-15 2014-05-14 Trpa1 antagonist compounds WO2014184248A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361823706P 2013-05-15 2013-05-15
US61/823,706 2013-05-15

Publications (2)

Publication Number Publication Date
WO2014184248A2 WO2014184248A2 (en) 2014-11-20
WO2014184248A3 true WO2014184248A3 (en) 2014-12-31

Family

ID=50721797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/059853 WO2014184248A2 (en) 2013-05-15 2014-05-14 Trpa1 antagonist compounds

Country Status (1)

Country Link
WO (1) WO2014184248A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021506962A (en) * 2017-12-19 2021-02-22 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ Synthesis of 1: 1: 1 co-crystal consisting of 1-cyano-2- (4-cyclopropyl-benzyl) -4- (β-D-glucopyranos-1-yl) -benzene, L-proline and water
FR3114235A1 (en) * 2020-09-18 2022-03-25 Université Grenoble Alpes INHIBITION OF ASTROCYTIC TRPA1 CHANNEL AS A NEW NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050512A1 (en) * 2010-10-12 2012-04-19 Astrazeneca Ab Trpa1 receptor antagonist

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050512A1 (en) * 2010-10-12 2012-04-19 Astrazeneca Ab Trpa1 receptor antagonist

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VALLIN K S ET AL: "N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 22, no. 17, 1 September 2012 (2012-09-01), pages 5485 - 5492, XP002716178, ISSN: 0960-894X, [retrieved on 20120714], DOI: 10.1016/J.BMCL.2012.07.032 *

Also Published As

Publication number Publication date
WO2014184248A2 (en) 2014-11-20

Similar Documents

Publication Publication Date Title
WO2014209841A3 (en) Compounds for treating spinal muscular atrophy
PH12014502363A1 (en) N-aryltriazole compounds as lpar antagonists
PH12016500170A1 (en) Formulation of syk inhibitors
PH12014502789A1 (en) N-alkyltriazole compounds as lpar antagonists
WO2014151871A3 (en) Jak2 and alk2 inhibitors and methods for their use
WO2014045162A8 (en) ALKYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-d] [1,3]THIAZIN-2-AMINE COMPOUNDS
MX2015012432A (en) Pyridine cdk9 kinase inhibitors.
MX2014014229A (en) Substituted pyrrolidine-2-carboxamides.
PH12014501542A1 (en) Substituted pyrrolidine -2- carboxamides
WO2013004995A8 (en) Pyrimidinone compounds and their use
PH12018500377A1 (en) Novel annelated benzamides
JOP20190174A1 (en) Jak1 selective inhibitors
AU2015211852A1 (en) Heterocyclic sulfonamide derivative and medicine comprising same
WO2013112959A8 (en) Antifibrotic compounds and uses thereof
PH12018500378A1 (en) Novel annelated phenoxyacetamides
PH12014502364A1 (en) Substituted pyrazole compounds as lpar antagonists
EA201600619A1 (en) CHROMEN AND 1,1А, 2,7В-TETRAHYDROCYCLOPROP [С] CHROMEN PYRIDOPYRASINDION AS A GAMMA SECRETASE MODULATOR
WO2014102592A3 (en) Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
WO2014062838A3 (en) Pkm2 modulators and methods for their use
WO2014020405A8 (en) Cyclic urea- or lactam-substituted quinoxaline-type piperidine compounds and the uses thereof
WO2014201016A3 (en) Inhibitors of the mitf molecular pathway
MX2017013099A (en) Methods for the treatment of inflammatory disorders.
EA201700356A1 (en) NEW CYCLOPROPANBENZOFURANILPYRIDOPYRAZINDIONS
WO2015002755A3 (en) Compounds for the treatment of malaria
WO2014184248A3 (en) Trpa1 antagonist compounds

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14723812

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14723812

Country of ref document: EP

Kind code of ref document: A2