WO2014181309A1 - Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes - Google Patents
Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes Download PDFInfo
- Publication number
- WO2014181309A1 WO2014181309A1 PCT/IB2014/061338 IB2014061338W WO2014181309A1 WO 2014181309 A1 WO2014181309 A1 WO 2014181309A1 IB 2014061338 W IB2014061338 W IB 2014061338W WO 2014181309 A1 WO2014181309 A1 WO 2014181309A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- erythrocytes
- phosphate
- solution
- substances
- dexamethasone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01001—Hexokinase (2.7.1.1)
Abstract
Description
Claims
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112015028278-4A BR112015028278B1 (en) | 2013-05-10 | 2014-05-09 | PROCESS FOR THE PREPARATION OF ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST, ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST, PHARMACEUTICAL COMPOSITION AND THERAPEUTIC USE OF SAID ERYTHROCYTES |
ES14732387T ES2950419T3 (en) | 2013-05-10 | 2014-05-09 | Procedure for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and erythrocytes obtained in this way |
SG11201509252QA SG11201509252QA (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
AU2014264205A AU2014264205B2 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
KR1020157035053A KR102223080B1 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
EP23177290.6A EP4338803A2 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
JP2016512472A JP6367314B2 (en) | 2013-05-10 | 2014-05-09 | Method for preparing red blood cells loaded with one or more pharmaceutically important substances and red blood cells thus obtained |
MX2015015409A MX2015015409A (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes. |
CA2911976A CA2911976C (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
MA38625A MA38625B1 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest, and erythrocytes thus obtained |
US14/888,486 US10849858B2 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
EP14732387.7A EP2994117B1 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
RU2015152801A RU2670070C2 (en) | 2013-05-10 | 2014-05-09 | Process for preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
PL14732387.7T PL2994117T3 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
CN201480026710.XA CN105228596B (en) | 2013-05-10 | 2014-05-09 | It is used to prepare the method for the red blood cell for being loaded with one or more pharmaceutics substances of interest and thus obtained red blood cell |
PH12015502535A PH12015502535A1 (en) | 2013-05-10 | 2015-11-05 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
CR20150604A CR20150604A (en) | 2013-05-10 | 2015-11-05 | PROCESS FOR THE PREPARATION OF Erythrocytes Loaded With One Or More Substances Of Pharmaceutical Interest And Erythrocytes Thus Obtained |
IL242503A IL242503B (en) | 2013-05-10 | 2015-11-08 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
SA515370122A SA515370122B1 (en) | 2013-05-10 | 2015-11-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
US17/083,771 US20210283063A1 (en) | 2013-05-10 | 2020-10-29 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM2013A000280 | 2013-05-10 | ||
IT000280A ITRM20130280A1 (en) | 2013-05-10 | 2013-05-10 | PROCEDURE FOR THE PREPARATION OF ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST. |
ITRM2013A000610 | 2013-11-05 | ||
IT000610A ITRM20130610A1 (en) | 2013-11-05 | 2013-11-05 | ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/888,486 A-371-Of-International US10849858B2 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
US17/083,771 Continuation US20210283063A1 (en) | 2013-05-10 | 2020-10-29 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014181309A1 true WO2014181309A1 (en) | 2014-11-13 |
Family
ID=50981593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2014/061338 WO2014181309A1 (en) | 2013-05-10 | 2014-05-09 | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
Country Status (19)
Country | Link |
---|---|
US (2) | US10849858B2 (en) |
EP (2) | EP2994117B1 (en) |
JP (1) | JP6367314B2 (en) |
KR (1) | KR102223080B1 (en) |
CN (1) | CN105228596B (en) |
AU (1) | AU2014264205B2 (en) |
BR (1) | BR112015028278B1 (en) |
CA (1) | CA2911976C (en) |
CR (1) | CR20150604A (en) |
ES (1) | ES2950419T3 (en) |
IL (1) | IL242503B (en) |
MX (1) | MX2015015409A (en) |
PH (1) | PH12015502535A1 (en) |
PL (1) | PL2994117T3 (en) |
PT (1) | PT2994117T (en) |
RU (1) | RU2670070C2 (en) |
SA (1) | SA515370122B1 (en) |
SG (1) | SG11201509252QA (en) |
WO (1) | WO2014181309A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9644180B2 (en) | 2013-11-18 | 2017-05-09 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
CN108883133A (en) * | 2015-12-22 | 2018-11-23 | 善威生物私人有限公司 | Use the treatment method of red blood cell |
CN111658772A (en) * | 2020-07-22 | 2020-09-15 | 南通大学 | Natural light induced controlled release medicine and preparation method and application thereof |
US10869898B2 (en) | 2014-04-01 | 2020-12-22 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
US11243218B2 (en) | 2015-10-07 | 2022-02-08 | Sangui Bio Pty Ltd. | Blood preparation and profiling |
US11693006B2 (en) | 2016-12-20 | 2023-07-04 | Sangui Bio Pty. Ltd | Blood profiling with protease inhibitors |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101671361B1 (en) * | 2016-08-08 | 2016-11-01 | 에스씨엠생명과학 주식회사 | Pharmaceutical composition for preventing or treating hair loss comprising TYMP(thymidine phosphorylase) protein |
WO2020099592A1 (en) | 2018-11-15 | 2020-05-22 | Erytech Pharma | Synergistic combinations of methionine depletion agents and immune checkpoint modulators |
CN109453137A (en) * | 2018-12-07 | 2019-03-12 | 上海交通大学 | A kind of red blood cell living carries the sustained release preparation and the preparation method and application thereof of betamethasone sodium phosphate |
CN113008653A (en) * | 2019-12-20 | 2021-06-22 | 深圳市帝迈生物技术有限公司 | Diluent, hemocyte analyzer, reagent for hemocyte analyzer, and kit |
AU2021270347A1 (en) | 2020-05-11 | 2022-12-15 | Erytech Pharma | Red cell extracellular vesicles (RCEVs) containing cargoes and methods of use and production thereof |
WO2022248975A1 (en) | 2021-05-27 | 2022-12-01 | Erydel S.P.A. | Engineering new metabolic pathways in isolated cells for the degradation of guanidinoacetic acid and simultaneous production of creatine |
WO2023027613A1 (en) * | 2021-08-27 | 2023-03-02 | Общество С Ограниченной Ответственностью "Рбк-Фармэко" | Device and method for incorporating biologically active agents into red blood cells by continuous flow dialysis |
CN114469865B (en) * | 2022-03-17 | 2023-09-22 | 中国医学科学院输血研究所 | Liposome drug carrier combined with blood cell membrane and preparation method and application thereof |
Citations (5)
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US4327710A (en) * | 1980-06-18 | 1982-05-04 | The United States Of America As Represented By The Secretary Of Agriculture | Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system |
EP0882448A1 (en) | 1997-05-05 | 1998-12-09 | DIDECO S.p.A. | Method of encapsulating biologically active agents within erythrocytes and apparatus therefor |
ITBO20100255A1 (en) | 2010-04-26 | 2011-10-27 | Erydel Spa | APPARATUS AND KIT FOR ENCAPSING AT LEAST A COMPOUND FOR THERAPEUTIC AND / OR DIAGNOSTIC USE WITHIN ERYTHROCYTES |
WO2011135431A1 (en) * | 2010-04-26 | 2011-11-03 | Erydel S.P.A. | Method for introducing at least one compound within erythrocytes for therapeutical and/or diagnostic use |
EP1773452B1 (en) | 2004-08-05 | 2011-11-09 | Erytech Pharma | Lysis / resealing process for incorporating an active ingredient in erythrocytes |
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SU1807595A1 (en) * | 1989-10-16 | 1996-08-10 | Целиноградский государственный медицинский институт Минздрава КазССР | Agent for treatment against mercury intoxication |
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KR100478791B1 (en) * | 2002-07-11 | 2005-03-24 | 오유경 | Erythrocyte ghosts containing a desired gene for biocompatible gene delivery systems |
-
2014
- 2014-05-09 WO PCT/IB2014/061338 patent/WO2014181309A1/en active Application Filing
- 2014-05-09 ES ES14732387T patent/ES2950419T3/en active Active
- 2014-05-09 SG SG11201509252QA patent/SG11201509252QA/en unknown
- 2014-05-09 CN CN201480026710.XA patent/CN105228596B/en active Active
- 2014-05-09 PL PL14732387.7T patent/PL2994117T3/en unknown
- 2014-05-09 CA CA2911976A patent/CA2911976C/en active Active
- 2014-05-09 US US14/888,486 patent/US10849858B2/en active Active
- 2014-05-09 BR BR112015028278-4A patent/BR112015028278B1/en active IP Right Grant
- 2014-05-09 PT PT147323877T patent/PT2994117T/en unknown
- 2014-05-09 EP EP14732387.7A patent/EP2994117B1/en active Active
- 2014-05-09 KR KR1020157035053A patent/KR102223080B1/en active IP Right Grant
- 2014-05-09 AU AU2014264205A patent/AU2014264205B2/en active Active
- 2014-05-09 JP JP2016512472A patent/JP6367314B2/en active Active
- 2014-05-09 MX MX2015015409A patent/MX2015015409A/en active IP Right Grant
- 2014-05-09 RU RU2015152801A patent/RU2670070C2/en active
- 2014-05-09 EP EP23177290.6A patent/EP4338803A2/en active Pending
-
2015
- 2015-11-05 PH PH12015502535A patent/PH12015502535A1/en unknown
- 2015-11-05 CR CR20150604A patent/CR20150604A/en unknown
- 2015-11-08 IL IL242503A patent/IL242503B/en active IP Right Grant
- 2015-11-09 SA SA515370122A patent/SA515370122B1/en unknown
-
2020
- 2020-10-29 US US17/083,771 patent/US20210283063A1/en active Pending
Patent Citations (6)
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US4327710A (en) * | 1980-06-18 | 1982-05-04 | The United States Of America As Represented By The Secretary Of Agriculture | Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system |
EP0882448A1 (en) | 1997-05-05 | 1998-12-09 | DIDECO S.p.A. | Method of encapsulating biologically active agents within erythrocytes and apparatus therefor |
EP1773452B1 (en) | 2004-08-05 | 2011-11-09 | Erytech Pharma | Lysis / resealing process for incorporating an active ingredient in erythrocytes |
ITBO20100255A1 (en) | 2010-04-26 | 2011-10-27 | Erydel Spa | APPARATUS AND KIT FOR ENCAPSING AT LEAST A COMPOUND FOR THERAPEUTIC AND / OR DIAGNOSTIC USE WITHIN ERYTHROCYTES |
WO2011135431A1 (en) * | 2010-04-26 | 2011-11-03 | Erydel S.P.A. | Method for introducing at least one compound within erythrocytes for therapeutical and/or diagnostic use |
WO2011135429A1 (en) * | 2010-04-26 | 2011-11-03 | Erydel S.P.A. | Apparatus and kit for encapsulating at least one compound for therapeutic and/or diagnostic use in erythrocytes |
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DRABKIN DL, MED SCI, 1949 |
REENA GILL: "Resealed erythrocytes as a potential drug carrier system", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 1 February 2012 (2012-02-01), pages 383 - 397, XP055124742, Retrieved from the Internet <URL:http://ijpsr.com/V3I2/12%20Vol.%203,%20Issue%202,%20Feb.%202012,%20IJPSR-431,%20Paper%2012.pdf> [retrieved on 20140624] * |
ROPARS C ET AL: "RESEALED RED BLOOD CELLS AS A NEW BLOOD TRANSFUSION PRODUCT", BIBLIOTHECA HAEMATOLOGICA, BASEL, CH, no. 51, 1 January 1985 (1985-01-01), pages 82 - 91, XP002043887, ISSN: 0067-7957 * |
SABRINA BUONI ET AL: "Betamethasone and Improvement of Neurological Symptoms in Ataxia-Telangiectasia", ARCHIVES OF NEUROLOGY, vol. 63, no. 10, 1 October 2006 (2006-10-01), pages 1479, XP055124752, ISSN: 0003-9942, DOI: 10.1001/archneur.63.10.1479 * |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10253296B2 (en) | 2013-11-18 | 2019-04-09 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
US10301593B2 (en) | 2013-11-18 | 2019-05-28 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
US10301594B1 (en) | 2013-11-18 | 2019-05-28 | Rubius Therapeutics, Inc | Synthetic membrane-receiver complexes |
US10329531B2 (en) | 2013-11-18 | 2019-06-25 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
US10344263B2 (en) | 2013-11-18 | 2019-07-09 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
US9644180B2 (en) | 2013-11-18 | 2017-05-09 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
US10557119B2 (en) | 2013-11-18 | 2020-02-11 | Rubius Therapeutics, Inc. | Erythroid cells comprising phenylalanine ammonia lyase |
US10869898B2 (en) | 2014-04-01 | 2020-12-22 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
US11576934B2 (en) | 2014-04-01 | 2023-02-14 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
US11554141B2 (en) | 2014-04-01 | 2023-01-17 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
US11243218B2 (en) | 2015-10-07 | 2022-02-08 | Sangui Bio Pty Ltd. | Blood preparation and profiling |
EP3393482A4 (en) * | 2015-12-22 | 2019-08-21 | Sangui Bio Pty. Ltd | Therapeutic methods using erythrocytes |
JP2021155454A (en) * | 2015-12-22 | 2021-10-07 | サングイ バイオ ピーティーワイ. エルティーディー | Treatment method using erythrocyte |
JP2018538343A (en) * | 2015-12-22 | 2018-12-27 | サングイ バイオ ピーティーワイ. エルティーディー | Treatment method using red blood cells |
US11564948B2 (en) | 2015-12-22 | 2023-01-31 | Sangui Bio Pty Ltd | Therapeutic methods using erythrocytes |
CN108883133A (en) * | 2015-12-22 | 2018-11-23 | 善威生物私人有限公司 | Use the treatment method of red blood cell |
US11693006B2 (en) | 2016-12-20 | 2023-07-04 | Sangui Bio Pty. Ltd | Blood profiling with protease inhibitors |
CN111658772A (en) * | 2020-07-22 | 2020-09-15 | 南通大学 | Natural light induced controlled release medicine and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
BR112015028278B1 (en) | 2022-12-20 |
CR20150604A (en) | 2016-03-09 |
JP6367314B2 (en) | 2018-08-01 |
CN105228596A (en) | 2016-01-06 |
SG11201509252QA (en) | 2015-12-30 |
IL242503B (en) | 2020-08-31 |
RU2015152801A (en) | 2017-06-16 |
KR20160005781A (en) | 2016-01-15 |
SA515370122B1 (en) | 2016-11-08 |
PH12015502535B1 (en) | 2016-02-22 |
CA2911976C (en) | 2021-01-19 |
CN105228596B (en) | 2018-08-24 |
US20160051482A1 (en) | 2016-02-25 |
EP2994117B1 (en) | 2023-06-07 |
BR112015028278A2 (en) | 2017-07-25 |
US20210283063A1 (en) | 2021-09-16 |
KR102223080B1 (en) | 2021-03-04 |
RU2670070C2 (en) | 2018-10-17 |
AU2014264205B2 (en) | 2018-08-30 |
AU2014264205A1 (en) | 2015-11-12 |
JP2016518402A (en) | 2016-06-23 |
EP4338803A2 (en) | 2024-03-20 |
PL2994117T3 (en) | 2023-10-16 |
PT2994117T (en) | 2023-07-14 |
CA2911976A1 (en) | 2014-11-13 |
EP2994117A1 (en) | 2016-03-16 |
ES2950419T3 (en) | 2023-10-09 |
MX2015015409A (en) | 2016-06-02 |
PH12015502535A1 (en) | 2016-02-22 |
US10849858B2 (en) | 2020-12-01 |
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