WO2014180882A3 - Traitement des métastases cérébrales d'un cancer - Google Patents
Traitement des métastases cérébrales d'un cancer Download PDFInfo
- Publication number
- WO2014180882A3 WO2014180882A3 PCT/EP2014/059303 EP2014059303W WO2014180882A3 WO 2014180882 A3 WO2014180882 A3 WO 2014180882A3 EP 2014059303 W EP2014059303 W EP 2014059303W WO 2014180882 A3 WO2014180882 A3 WO 2014180882A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- brain metastasis
- treatment
- metastasis
- brain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne l'utilisation de composés de formule (I), d'inhibiteurs de GRP94 et d'inhibiteurs d'HDAC dans le traitement d'une métastase cérébrale d'un cancer, de préférence une métastase cérébrale d'un cancer du sein ou une métastase cérébrale d'un cancer du poumon.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361820444P | 2013-05-07 | 2013-05-07 | |
EP13382168.6 | 2013-05-07 | ||
EP13382168 | 2013-05-07 | ||
US61/820,444 | 2013-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014180882A2 WO2014180882A2 (fr) | 2014-11-13 |
WO2014180882A3 true WO2014180882A3 (fr) | 2015-01-08 |
Family
ID=48236835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2014/059303 WO2014180882A2 (fr) | 2013-05-07 | 2014-05-07 | Traitement des métastases cérébrales d'un cancer |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014180882A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015341301B2 (en) | 2014-10-30 | 2019-05-16 | Kangpu Biopharmaceuticals, Ltd. | Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof |
AU2019381688A1 (en) | 2018-11-13 | 2021-06-03 | Biotheryx, Inc. | Substituted isoindolinones |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087307A2 (fr) * | 2000-05-15 | 2001-11-22 | Celgene Corp. | Compositions et methodes de traitement du cancer |
WO2005046593A2 (fr) * | 2003-11-06 | 2005-05-26 | Celgene Corporation | Methodes et compositions faisant appel a du thalidomide pour le traitement et pour la gestion de cancers et d'autres maladies |
-
2014
- 2014-05-07 WO PCT/EP2014/059303 patent/WO2014180882A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087307A2 (fr) * | 2000-05-15 | 2001-11-22 | Celgene Corp. | Compositions et methodes de traitement du cancer |
WO2005046593A2 (fr) * | 2003-11-06 | 2005-05-26 | Celgene Corporation | Methodes et compositions faisant appel a du thalidomide pour le traitement et pour la gestion de cancers et d'autres maladies |
Non-Patent Citations (7)
Title |
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"1200 POSTER Phase II study of thalidomide in patients with brain metastases from malignant melanoma", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, vol. 3, no. 2, 1 October 2005 (2005-10-01), pages 347, XP027684237, ISSN: 1359-6349, [retrieved on 20051001] * |
ADAM S. DUERFELDT ET AL: "Development of a Grp94 inhibitor", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 23, 13 June 2012 (2012-06-13), pages 9796 - 9804, XP055128967, ISSN: 0002-7863, DOI: 10.1021/ja303477g * |
BARTLETT J B ET AL: "Phase 1 study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers", BRITISH JOURNAL OF CANCER, vol. 90, no. 5, 8 March 2004 (2004-03-08), pages 955 - 961, XP002727210, ISSN: 0007-0920 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; October 2005 (2005-10-01), HADA MASATO ET AL: "[A case report of chemotherapy with thalidomide, celecoxib and gemcitabine in the treatment of patients with brain metastases from lung cancer].", XP002727211, Database accession no. NLM16223182 * |
KARIN OECHSLE ET AL: "Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumors", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, BERLIN, DE, vol. 136, no. 1, 16 September 2009 (2009-09-16), pages 165 - 167, XP019760639, ISSN: 1432-1335 * |
KNISELY J P S ET AL: "A Phase III Study of Conventional Radiation Therapy Plus Thalidomide Versus Conventional Radiation Therapy for Multiple Brain Metastases (RTOG 0118)", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, USA, vol. 71, no. 1, 1 May 2008 (2008-05-01), pages 79 - 86, XP022606146, ISSN: 0360-3016, [retrieved on 20071231], DOI: 10.1016/J.IJROBP.2007.09.016 * |
VESTERMARK LENE W ET AL: "A phase II study of thalidomide in patients with brain metastases from malignant melanoma.", ACTA ONCOLOGICA (STOCKHOLM, SWEDEN) 2008, vol. 47, no. 8, 2008, pages 1526 - 1530, XP002727209, ISSN: 1651-226X * |
Also Published As
Publication number | Publication date |
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WO2014180882A2 (fr) | 2014-11-13 |
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