WO2014169845A3 - 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof - Google Patents
4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof Download PDFInfo
- Publication number
- WO2014169845A3 WO2014169845A3 PCT/CN2014/075683 CN2014075683W WO2014169845A3 WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3 CN 2014075683 W CN2014075683 W CN 2014075683W WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrid
- pyrazolo
- dihydro
- ones
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
The present invention relates to 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, as shown in Formula (I), and to a preparation method and an application thereof; the definition of each substituent in the Formula (I) compound is the same as the definition found in the description.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201480003262.1A CN105026392B (en) | 2013-04-19 | 2014-04-18 | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310138026.8 | 2013-04-19 | ||
CN201310138026 | 2013-04-19 | ||
CN201310372920.1 | 2013-08-23 | ||
CN201310372920 | 2013-08-23 | ||
CN201310428690.6 | 2013-09-18 | ||
CN201310428690.6A CN104109165A (en) | 2013-04-19 | 2013-09-18 | 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives, and preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014169845A2 WO2014169845A2 (en) | 2014-10-23 |
WO2014169845A3 true WO2014169845A3 (en) | 2014-12-11 |
Family
ID=51706170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2014/075683 WO2014169845A2 (en) | 2013-04-19 | 2014-04-18 | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof |
Country Status (2)
Country | Link |
---|---|
CN (2) | CN104109165A (en) |
WO (1) | WO2014169845A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3064497A1 (en) * | 2015-07-20 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Dimer impurities of apixaban and method to remove them |
ES2819830T3 (en) | 2016-03-17 | 2021-04-19 | Hoffmann La Roche | Derivative of 5-ethiol-4-methyl-pyrazole-3-carboxamide having activity as a TAAR agonist |
CN107474030B (en) * | 2016-06-08 | 2021-03-30 | 首都医科大学 | Warfarin-aspirin conjugates, their synthesis, antithrombotic activity and uses |
CN109232596B (en) * | 2018-09-05 | 2020-03-17 | 大连九信精细化工有限公司 | Synthetic method of dibenzofuran carbazole |
CN110143914B (en) * | 2019-06-21 | 2022-03-29 | 常州恒邦药业有限公司 | Preparation method of apixaban intermediate |
BR112023024741A2 (en) | 2021-05-27 | 2024-02-15 | Jiangsu Hengrui Pharmaceuticals Co Ltd | QUINOLINAMINE COMPOUND, PREPARATION METHOD FOR THE SAME AND APPLICATION OF THE SAME IN PHARMACEUTICAL PRODUCTS |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1391575A (en) * | 1998-12-23 | 2003-01-15 | 杜邦药品公司 | Nitrogen containing heterobicycles as factor XA inhibitors |
US20100048611A1 (en) * | 2006-05-31 | 2010-02-25 | Bayer Healthcare Ag | Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2410393A1 (en) * | 2000-06-23 | 2002-01-03 | Dupont Pharmaceuticals Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
PL204653B1 (en) * | 2001-09-21 | 2010-01-29 | Bristol Myers Squibb Co | Derivative of pyrazolo [3,4-c] pyridine, the use thereof and pharmaceutical composition |
TW200303201A (en) * | 2001-12-10 | 2003-09-01 | Bristol Myers Squibb Co | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
CN101065379B (en) * | 2004-09-28 | 2011-05-11 | 布里斯托尔-迈尔斯斯奎布公司 | Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
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2013
- 2013-09-18 CN CN201310428690.6A patent/CN104109165A/en active Pending
-
2014
- 2014-04-18 WO PCT/CN2014/075683 patent/WO2014169845A2/en active Application Filing
- 2014-04-18 CN CN201480003262.1A patent/CN105026392B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1391575A (en) * | 1998-12-23 | 2003-01-15 | 杜邦药品公司 | Nitrogen containing heterobicycles as factor XA inhibitors |
US20100048611A1 (en) * | 2006-05-31 | 2010-02-25 | Bayer Healthcare Ag | Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof |
Also Published As
Publication number | Publication date |
---|---|
CN105026392A (en) | 2015-11-04 |
CN105026392B (en) | 2017-05-10 |
WO2014169845A2 (en) | 2014-10-23 |
CN104109165A (en) | 2014-10-22 |
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