WO2014169744A1 - Method and system for evaluating effect of radiotherapy - Google Patents

Method and system for evaluating effect of radiotherapy Download PDF

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WO2014169744A1
WO2014169744A1 PCT/CN2014/073525 CN2014073525W WO2014169744A1 WO 2014169744 A1 WO2014169744 A1 WO 2014169744A1 CN 2014073525 W CN2014073525 W CN 2014073525W WO 2014169744 A1 WO2014169744 A1 WO 2014169744A1
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dose
tumor target
target area
physical
total
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PCT/CN2014/073525
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French (fr)
Chinese (zh)
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邓小武
张广顺
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深圳市医诺智能科技发展有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems

Definitions

  • the invention belongs to the technical field of medical software, and in particular relates to a method and a system for evaluating the effect of radiotherapy.
  • the radiotherapy physicist passes the radiotherapy planning system (Treatment).
  • TPS radiotherapy planning system
  • the radiotherapy plan of the TPS output includes therapeutic field parameters (mainly including the radiation parameters of the various moving parts of the accelerator, such as the radiation incident angle, the shape of the field, and the radiation energy, when the accelerator for generating the therapeutic radiation is irradiated to the tumor site.
  • radiologists Before radiotherapy for cancer patients, radiologists need to use computer simulation techniques to observe the distribution of physical doses in the human body, as well as the distribution of dose-volume histograms of DVH in specific doses of tumor targets and normal organs. The situation is to assess whether the radiotherapy plan designed by the physical technician meets the requirements of the treatment plan.
  • the physical dose reflects the ideal distribution of radiation after ideally absorbed by human tissue and does not fully reflect the biological effects of radiation therapy.
  • the killing of tumors and the damage of normal organs are more dependent on biological doses than on physical doses.
  • the same physical total doses, under different treatment times and treatment intervals, often produce larger biological effects. Differences, therefore, the evaluation of radiotherapy plans through a combination of physical dose and biological dose has more valuable clinical significance.
  • the radiotherapy physician can only carry out the plan evaluation by observing the physical dose distribution, the physical dose volume and other parameters through the plan evaluation function provided on the TPS, and there is a problem that the evaluation accuracy is insufficient.
  • the object of the embodiments of the present invention is to provide a method and a system for evaluating radiotherapy effects, so as to solve the problem that the radiotherapy doctors in the prior art can only provide the plan evaluation function provided by the TPS, by observing physical dose distribution, physical dose volume and the like. Conduct a plan assessment to assess the problem of insufficient accuracy.
  • An embodiment of the present invention is achieved by a method of evaluating a radiotherapy effect, the method comprising the steps of:
  • the three-dimensional coordinate data of each voxel point of the target area on the CT image, the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
  • the radiation therapy dose distribution matrix the structural contour information of the human organ and the tumor target area, and the radiotherapy field parameters, a single physical dose of each voxel point of the human organ and the tumor target area is obtained;
  • the radiotherapy effect is evaluated based on the equivalent biological dose and the single physical dose.
  • Another object of an embodiment of the present invention is to provide a system for evaluating a radiation therapy effect, the system comprising:
  • a receiving unit configured to receive an input computed tomography CT image, structural contour information of a human organ and a tumor target area, a radiation therapy dose distribution matrix, and a radiation therapy plan field parameter, and structural contour information of the human body and the tumor target area
  • the query unit is configured to query a single physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter;
  • a calculating unit configured to calculate an equivalent biological dose of each voxel point of the human body organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter;
  • the first evaluation unit is configured to evaluate the radiotherapy effect according to the equivalent biological dose and the single physical dose.
  • the equivalent biological dose is calculated by receiving the number of times of treatment, the time interval, and a single physical dose of each voxel point of the human organ and the tumor target area, according to the single physical dose and the equivalent biological dose.
  • the radiotherapy doctors in the prior art can only solve the problem of radiotherapy treatment by observing the physical dose distribution, physical dose volume and other parameters through the plan evaluation function provided on the TPS.
  • FIG. 1 is a flowchart of an implementation of a method for evaluating a radiotherapy effect according to an embodiment of the present invention
  • FIG. 2 is a block diagram of a system for evaluating a radiation therapy effect according to an embodiment of the present invention.
  • the embodiment of the invention provides a method for obtaining an evaluation effect of the radiotherapy, and the method is as shown in FIG. 1 , and the specific steps include:
  • Computed computed tomography Computed computed tomography (Computed) Tomography, CT) image, structural contour information of human organs and tumor targets, radiotherapy dose distribution matrix, and radiation therapy plan field parameters.
  • CT image, human organ and structural contour information of the tumor target area are generated by the CT imaging device, and the radiation therapy dose distribution matrix and the radiation therapy plan field parameter are determined by the radiation therapy planning system (Treatment) Planning System, TPS) is generated;
  • the CT image includes a position of a human body voxel in a three-dimensional space coordinate system, and the structural contour information of the human body and the tumor target area includes respective voxel points of the human body and the tumor target area on the CT image
  • the three-dimensional coordinate data, the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation therapy, the three-dimensional dose distribution matrix including the three-dimensional coordinate data and the three-dimensional coordinate corresponding to the single Subphysical dose
  • the radiotherapy plan field parameters include the number of treatments N and the time interval t between the two treatments.
  • the radiation treatment plan field parameters also include the angle of incidence of the radiation, the size and shape of the treatment field, the energy of the radiation, and the hop.
  • the number, etc. does not require the use of parameters such as the angle of incidence of radiation, the size and shape of the treatment field, the energy of the radiation, and the number of hops.
  • the single physical dose of each voxel point of the human body and the tumor target area is equal for each radiation treatment, and firstly, the individual body points of the human body and the tumor target area are queried. The total physical dose, then a single physical dose of each voxel point in the human organ and tumor target area is calculated based on the number of treatments.
  • the equivalent biological dose is for a single physical dose, and refers to the biological effect produced by a single physical dose combined with the human body, and can effectively reflect the effect of radiation therapy.
  • the radiotherapy effect is evaluated according to the equivalent biological dose and the single physical dose.
  • the method for implementing step S12 in the step includes:
  • the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
  • a single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
  • the total physical dose image plane is constructed to facilitate the subsequent query of the total physical dose of each voxel point of the human organ and the tumor target area.
  • the purpose of constructing the total physical dose image plane is to establish the total physical dose and the CT image.
  • the construction of the total physical dose image plane can also be replaced by the construction of the total physical dose and CT image relationship table. According to the total physical dose and the number of treatments of the radiotherapy field parameters, a single physical dose can be calculated.
  • the method for implementing step S14 in the step specifically includes:
  • a biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
  • the points where the equivalent biological dose values are equal to the points of the single physical dose value are respectively connected to form a biological isodose contour line and a physical isodose contour line.
  • the points with the equivalent biological dose values are connected to form a biological isodose contour line, which is formed by extracting the equivalent biological dose value for image segmentation, and using the boundary detection algorithm to obtain the dose region boundary coordinates for the designated dose region.
  • Point, using the contour tracking algorithm to connect the boundary coordinates to the vertices of the polygon connect to form the biological isodose contour, and connect the points with the same physical dose value on the CT image to form the physical isodose contour. Same as the biological isodose contour.
  • the foregoing method further includes:
  • the total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose, so that the treating physician can according to the dose volume
  • the histogram evaluates the effects of radiation therapy.
  • the volume of the human body and the tumor target area is calculated according to the CT image and the structural contour information of the human body and the tumor target area, and the CT image, and then the total equivalent biological dose and the total physical dose of the human body and the tumor target area are counted. , plot the dose volume histogram.
  • the embodiment of the present invention calculates a single physical dose and a corresponding biological dose value by receiving CT images, structural contour information of human organs and tumor target regions, radiation therapy dose distribution matrix, and radiation treatment plan field parameters. And forming a physical isodose contour and a biological isodose contour to make it easier for the treating physician to evaluate the effect of the radiation therapy, solving the problem that the prior art evaluation method cannot accurately evaluate the radiotherapy effect.
  • the embodiment of the present invention provides a system for evaluating a radiotherapy effect, and the system for evaluating the radiotherapy effect is as shown in FIG. 2, and specifically includes:
  • the receiving unit 21 is configured to receive the input computed tomography CT image, the structural contour information of the human body and the tumor target area, the radiation therapy dose distribution matrix, and the radiation therapy plan field parameter, the structural contour of the human body and the tumor target area
  • the information includes three-dimensional coordinate data of respective voxel points of the human body and the tumor target area on the CT image, and the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
  • the query unit 22 is configured to query a single physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter. ;
  • the calculating unit 23 is configured to calculate an equivalent biological dose of each voxel point of the human body organ and the tumor target area according to a single physical dose of each voxel point of the human body and the tumor target area and a radiation treatment plan field parameter;
  • the first evaluation unit 24 is configured to evaluate the radiotherapy effect according to the equivalent biological dose and the single physical dose.
  • the query unit 22 is specifically configured to:
  • the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
  • a single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
  • the first evaluation unit 24 is specifically configured to:
  • a biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
  • system further includes:
  • a second evaluation unit configured to calculate a volume of each organ and a tumor target area and a total equivalent organism according to the equivalent biological dose value, a single physical dose value, structural contour information of a human organ and a tumor target area, and a CT image Dose and total physical dose;
  • the total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose of each organ and tumor target area, so that treatment is performed
  • the physician can evaluate the radiotherapy effect based on the dose volume histogram.
  • each module included in the foregoing embodiment is only divided according to functional logic, but is not limited to the above division, as long as the corresponding function can be implemented; in addition, the specific name of each functional module It is also for convenience of distinguishing from each other and is not intended to limit the scope of protection of the present invention.
  • the storage medium includes a ROM/RAM or the like.

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Abstract

Disclosed are a method and a system for evaluating the effect of radiotherapy, relating to the technical field of medical software. The method comprises: receiving an input computed tomography CT image, structure contour information of a human organ and a tumour target area, a distribution matrix of a radiotherapy dosage and a radiotherapy planning radiation field parameter; obtaining the single physical dosage of each voxel point of the human organ and the tumour target area through identification; calculating the biological equivalent dosage of each voxel point of the human organ and the tumour target according to the single physical dosage of each voxel point of the human organ and the tumour target and the radiotherapy planning radiation field parameter; and evaluating the effect of radiotherapy according to the biological equivalent dosage and the single physical dosage. Obtaining the single physical dosage through identification, calculating the biological equivalent dosage and constructing a corresponding contour line solves the problem of inaccurate evaluation of the effect of radiotherapy which is present in the prior art.

Description

一种评估放射治疗效果方法及系统  Method and system for evaluating radiotherapy effect 技术领域Technical field
本发明属于医疗软件技术领域，尤其涉及一种评估放射治疗效果方法及系统。 The invention belongs to the technical field of medical software, and in particular relates to a method and a system for evaluating the effect of radiotherapy.
背景技术Background technique
在肿瘤放射治疗领域，放疗医师在给肿瘤患者安排基于放射线照射的放射治疗方案后，由放疗物理技师通过放疗计划系统（Treatment Planning System，TPS）设计出符合治疗方案要求的放疗计划。TPS输出的放疗计划中包括有治疗射野参数（主要包括产生治疗用放射线的加速器针对肿瘤部位进行放射线治疗照射时，加速器的各个运动部件的运动参数，如放射线入射角度、射野形状、放射线能量、跳数、照射总分次数等），患者人体吸收的物理剂量在患者体内的三维剂量分布，由CT断层扫描设备扫描产生的CT断层扫描图像，以及设计计划前有放疗医师在CT图像上所勾画的用于描述患者人体器官及肿瘤部位的轮廓形状和位置的结构数据。In the field of tumor radiotherapy, after the radiation therapy program is arranged for the tumor patients by radiotherapy, the radiotherapy physicist passes the radiotherapy planning system (Treatment). Planning System, TPS) designed a radiotherapy plan that meets the requirements of the treatment plan. The radiotherapy plan of the TPS output includes therapeutic field parameters (mainly including the radiation parameters of the various moving parts of the accelerator, such as the radiation incident angle, the shape of the field, and the radiation energy, when the accelerator for generating the therapeutic radiation is irradiated to the tumor site. , hop count, total number of exposures, etc.), the three-dimensional dose distribution of the physical dose absorbed by the patient in the patient, the CT tomography image generated by the CT tomography scan, and the CT image on the radiologist before the design plan Delineated structural data used to describe the contour shape and location of the patient's human organs and tumor sites.
　　在对肿瘤患者进行放射治疗前，放疗医师需要借助于计算机模拟技术，通过观察物理剂量在人体内的梯度分布情况，以及肿瘤靶区和正常器官受到的特定剂量照射的剂量体积直方图DVH的分布情况，来评估物理技师所设计的放疗计划的是否符合治疗方案的要求。Before radiotherapy for cancer patients, radiologists need to use computer simulation techniques to observe the distribution of physical doses in the human body, as well as the distribution of dose-volume histograms of DVH in specific doses of tumor targets and normal organs. The situation is to assess whether the radiotherapy plan designed by the physical technician meets the requirements of the treatment plan.
　　物理剂量所反映的是放射线在理想情况下被人体组织吸收后其剂量的理想分布情况，并不能完全反映出放射治疗的生物效应。肿瘤的灭杀和正常器官的损伤更依赖于生物剂量而不仅仅是物理剂量，相同的物理总剂量，在不同的治疗次数、治疗时间间隔的条件下，所产生的生物学效应往往有较大差别，因此通过物理剂量和生物剂量结合的方式对放疗计划进行评估，具有更有价值的临床意义。但目前的技术条件下，放疗医师只能通过TPS上提供的计划评估功能，通过观察物理剂量分布、物理剂量体积等参数来进行计划评估，存在评估准确性不够的问题。The physical dose reflects the ideal distribution of radiation after ideally absorbed by human tissue and does not fully reflect the biological effects of radiation therapy. The killing of tumors and the damage of normal organs are more dependent on biological doses than on physical doses. The same physical total doses, under different treatment times and treatment intervals, often produce larger biological effects. Differences, therefore, the evaluation of radiotherapy plans through a combination of physical dose and biological dose has more valuable clinical significance. However, under the current technical conditions, the radiotherapy physician can only carry out the plan evaluation by observing the physical dose distribution, the physical dose volume and other parameters through the plan evaluation function provided on the TPS, and there is a problem that the evaluation accuracy is insufficient.
技术问题technical problem
本发明实施例的目的在于提供一种评估放射治疗效果方法及系统，以解决现有技术存在的放疗医师只能通过TPS上提供的计划评估功能，通过观察物理剂量分布、物理剂量体积等参数来进行计划评估，评估准确性不够的问题。 The object of the embodiments of the present invention is to provide a method and a system for evaluating radiotherapy effects, so as to solve the problem that the radiotherapy doctors in the prior art can only provide the plan evaluation function provided by the TPS, by observing physical dose distribution, physical dose volume and the like. Conduct a plan assessment to assess the problem of insufficient accuracy.
技术解决方案Technical solution
本发明的实施例是这样实现的,一种评估放射治疗效果方法,所述方法包括以下步骤:An embodiment of the present invention is achieved by a method of evaluating a radiotherapy effect, the method comprising the steps of:
　　接收输入的计算机断层扫描CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上的三维坐标数据，所述放射治疗剂量分布矩阵为经过放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵；Receiving input computed tomography CT images, structural contour information of human organs and tumor target regions, radiation therapy dose distribution matrix, and radiation therapy plan field parameters, the structural contour information of the human organs and tumor target regions including human organs and tumors The three-dimensional coordinate data of each voxel point of the target area on the CT image, the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
　　根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量；According to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiotherapy field parameters, a single physical dose of each voxel point of the human organ and the tumor target area is obtained;
　　根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量；Calculating an equivalent biological dose of each voxel point of the human organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter;
　　根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。The radiotherapy effect is evaluated based on the equivalent biological dose and the single physical dose.
　　本发明的实施例的另一目的在于提供一种评估放射治疗效果系统，所述系统包括：Another object of an embodiment of the present invention is to provide a system for evaluating a radiation therapy effect, the system comprising:
　　接收单元，用于接收输入的计算机断层扫描CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上的三维坐标数据，所述放射治疗剂量分布矩阵为经过放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵；a receiving unit, configured to receive an input computed tomography CT image, structural contour information of a human organ and a tumor target area, a radiation therapy dose distribution matrix, and a radiation therapy plan field parameter, and structural contour information of the human body and the tumor target area The three-dimensional coordinate data of each voxel point of the human body and the tumor target area on the CT image, wherein the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
　　查询单元，用于根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量；The query unit is configured to query a single physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter;
　　计算单元，用于根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量；a calculating unit, configured to calculate an equivalent biological dose of each voxel point of the human body organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter;
　　第一评估单元，用于根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。The first evaluation unit is configured to evaluate the radiotherapy effect according to the equivalent biological dose and the single physical dose.
有益效果Beneficial effect
本发明实施例通过接收治疗的次数、时间间隔以及查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量，计算出等效生物剂量，根据所述单次物理剂量和等效生物剂量评估放射治疗效果，解决了现有技术存在的放疗医师只能通过TPS上提供的计划评估功能，通过观察物理剂量分布、物理剂量体积等参数来进行计划评估，无法准确评估放射治疗效果的问题。 In the embodiment of the present invention, the equivalent biological dose is calculated by receiving the number of times of treatment, the time interval, and a single physical dose of each voxel point of the human organ and the tumor target area, according to the single physical dose and the equivalent biological dose. To evaluate the effect of radiotherapy, the radiotherapy doctors in the prior art can only solve the problem of radiotherapy treatment by observing the physical dose distribution, physical dose volume and other parameters through the plan evaluation function provided on the TPS.
附图说明DRAWINGS
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the embodiments or the description of the prior art will be briefly described below. It is obvious that the drawings in the following description are only the present invention. For some embodiments, other drawings may be obtained from those of ordinary skill in the art without departing from the drawings.
　　图1是本发明实施例提供的评估放射治疗效果方法的实现流程图；1 is a flowchart of an implementation of a method for evaluating a radiotherapy effect according to an embodiment of the present invention;
　　图2是本发明实施例提供的评估放射治疗效果系统的模块结构图。2 is a block diagram of a system for evaluating a radiation therapy effect according to an embodiment of the present invention.
本发明的实施方式Embodiments of the invention
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
　　本发明实施例提供了获取评估放射治疗效果方法,所述方法如图1所示,具体步骤包括:The embodiment of the invention provides a method for obtaining an evaluation effect of the radiotherapy, and the method is as shown in FIG. 1 , and the specific steps include:
　　S11、接收输入的计算机断层扫描(Computed Tomography，CT)图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数。S11. Computed computed tomography (Computed) Tomography, CT) image, structural contour information of human organs and tumor targets, radiotherapy dose distribution matrix, and radiation therapy plan field parameters.
　　在本实施例中，CT图像、人体器官和肿瘤靶区的结构轮廓信息由CT成像设备生成，放射治疗剂量分布矩阵和放射治疗计划射野参数由放射治疗计划系统（Treatment Planning System，TPS）生成；所述CT图像包含人体体素在三维空间坐标系的位置，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上三维坐标数据，所述放射治疗剂量分布矩阵为经过所述放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵，所述三维剂量分布矩阵包括三维坐标数据和三维坐标对应的单次物理剂量所述放射治疗计划射野参数包括治疗次数N和两次治疗的时间间隔t，放射治疗计划射野参数还包括放射线的入射角度、治疗射野的大小和形状、放射线的能量和跳数等，不过本实施例不需要用到放射线的入射角度、治疗射野的大小和形状、放射线的能量和跳数等参数。In the present embodiment, CT image, human organ and structural contour information of the tumor target area are generated by the CT imaging device, and the radiation therapy dose distribution matrix and the radiation therapy plan field parameter are determined by the radiation therapy planning system (Treatment) Planning System, TPS) is generated; the CT image includes a position of a human body voxel in a three-dimensional space coordinate system, and the structural contour information of the human body and the tumor target area includes respective voxel points of the human body and the tumor target area on the CT image The three-dimensional coordinate data, the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation therapy, the three-dimensional dose distribution matrix including the three-dimensional coordinate data and the three-dimensional coordinate corresponding to the single Subphysical dose The radiotherapy plan field parameters include the number of treatments N and the time interval t between the two treatments. The radiation treatment plan field parameters also include the angle of incidence of the radiation, the size and shape of the treatment field, the energy of the radiation, and the hop. The number, etc., does not require the use of parameters such as the angle of incidence of radiation, the size and shape of the treatment field, the energy of the radiation, and the number of hops.
　　S12、根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量。S12. Query a single physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter.
　　在本实施例中，在多次放射治疗中，每次放射治疗时人体器官和肿瘤靶区各个体素点的单次物理剂量是相等的，首先查询人体器官和肿瘤靶区各个体素点的总物理剂量，然后根据治疗次数计算得到人体器官和肿瘤靶区各个体素点的单次物理剂量。In the present embodiment, in the multiple radiation therapy, the single physical dose of each voxel point of the human body and the tumor target area is equal for each radiation treatment, and firstly, the individual body points of the human body and the tumor target area are queried. The total physical dose, then a single physical dose of each voxel point in the human organ and tumor target area is calculated based on the number of treatments.
　　S13、根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量。S13. Calculate an equivalent biological dose of each voxel point of the human organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter.
　　需要说明的是，等效生物剂量是针对单次物理剂量而言的，是指单次物理剂量与人体结合所产生的生物效果，能够有效反应放射治疗的效果。It should be noted that the equivalent biological dose is for a single physical dose, and refers to the biological effect produced by a single physical dose combined with the human body, and can effectively reflect the effect of radiation therapy.
　　S14、根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。S14. The radiotherapy effect is evaluated according to the equivalent biological dose and the single physical dose.
　　可选的，实现步骤所述S12的方法包括：Optionally, the method for implementing step S12 in the step includes:
　　根据所述放射治疗剂量分布矩阵的三维坐标数据和三维坐标对应的总物理剂量，在CT图像上选取三维坐标与所述放射治疗剂量分布矩阵的三维坐标重合点，构建总物理剂量图像平面；Forming a total physical dose image plane according to the three-dimensional coordinate data of the radiation therapy dose distribution matrix and the total physical dose corresponding to the three-dimensional coordinates, selecting a three-dimensional coordinate coincident with the three-dimensional coordinates of the radiation therapy dose distribution matrix on the CT image;
　　根据人体器官和肿瘤靶区各个体素点在CT图像上的三维坐标数据，查询得到人体器官和肿瘤靶区各个体素点的总物理剂量；According to the three-dimensional coordinate data of the individual organ points of the human body and the tumor target area on the CT image, the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
　　根据人体器官和肿瘤靶区各个体素点的总物理剂量以及放射治疗射野参数总的治疗次数，计算得到人体器官和肿瘤靶区各个体素点的单次物理剂量。A single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
　　需要说明的是，构建总物理剂量图像平面是为了方便后面查询人体器官和肿瘤靶区各个体素点的总物理剂量，构建总物理剂量图像平面的目的是让总物理剂量和CT图像建立联系，构建总物理剂量图像平面也可以使用构建总物理剂量与CT图像关系表格来替代，根据总物理剂量和放射治疗射野参数的治疗次数，可以计算得到单次物理剂量It should be noted that the total physical dose image plane is constructed to facilitate the subsequent query of the total physical dose of each voxel point of the human organ and the tumor target area. The purpose of constructing the total physical dose image plane is to establish the total physical dose and the CT image. The construction of the total physical dose image plane can also be replaced by the construction of the total physical dose and CT image relationship table. According to the total physical dose and the number of treatments of the radiotherapy field parameters, a single physical dose can be calculated.
　　可选的，实现步骤所述S13的方法包括：BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× tOptionally, the method for implementing step S13 in the step includes: BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t
　　其中，所述为人体器官和肿瘤靶区各个体素点的等效生物剂量，所述为预存的剂量效应系数，所述K为预存的剂量修正参数，所述d为人体器官和肿瘤靶区各个体素点的单次物理剂量，所述N为治疗次数，所述t为治疗之间的时间间隔，所述放射治疗计划射野参数包括治疗次数和治疗之间的时间间隔。Wherein, the equivalent biological dose of each voxel point of the human organ and the tumor target area, the pre-existing dose effect coefficient, the K being a pre-existing dose correction parameter, the d being a human organ and a tumor target area A single physical dose of each voxel point, said N being the number of treatments, said t being the time interval between treatments, said radiation therapy plan field parameters including the number of treatments and the time interval between treatments.
　　可选的，实现步骤所述S14的方法具体包括：Optionally, the method for implementing step S14 in the step specifically includes:
　　在CT图像上分别将所述等效生物剂量值相等的点和所述单次物理剂量值相等的点连接起来，形成生物等剂量轮廓线和物理等剂量轮廓线；Connecting points equal to the equivalent biological dose value and points of the single physical dose value respectively on the CT image to form a biological isodose contour line and a physical isodose contour line;
　　将生物等剂量轮廓线和物理等剂量轮廓线显示在显示屏上，以使得治疗医师可以根据所述生物等剂量轮廓线和物理等剂量轮廓线评估放射治疗效果。A biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
　　需要说明的是，在CT图像上分别将所述等效生物剂量值相等的点和所述单次物理剂量值相等的点连接起来，形成生物等剂量轮廓线和物理等剂量轮廓线的意思是，在CT图像上将等效生物剂量值相等的点连接起来形成生物等剂量轮廓线，形成的方式是提取等效生物剂量值进行图像分割，对指定剂量区域利用边界检测算法获取剂量区域边界坐标点，利用轮廓跟踪算法将边界坐标点按多边形顶点连接方式，连接形成生物等剂量轮廓线，在CT图像上将单次物理剂量值相等的点连接起来，形成物理等剂量轮廓线，形成的方式和生物等剂量轮廓线一样。It should be noted that, on the CT image, the points where the equivalent biological dose values are equal to the points of the single physical dose value are respectively connected to form a biological isodose contour line and a physical isodose contour line. On the CT image, the points with the equivalent biological dose values are connected to form a biological isodose contour line, which is formed by extracting the equivalent biological dose value for image segmentation, and using the boundary detection algorithm to obtain the dose region boundary coordinates for the designated dose region. Point, using the contour tracking algorithm to connect the boundary coordinates to the vertices of the polygon, connect to form the biological isodose contour, and connect the points with the same physical dose value on the CT image to form the physical isodose contour. Same as the biological isodose contour.
　　可选的，上述方法还包括：Optionally, the foregoing method further includes:
　　根据所述等效生物剂量值、单次物理剂量值、人体器官和肿瘤靶区的结构轮廓信息以及CT图像，计算各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量；Calculating a volume of each organ and a tumor target area, and a total equivalent biological dose and a total physical dose according to the equivalent biological dose value, a single physical dose value, structural contour information of a human organ and a tumor target area, and a CT image;
　　根据所述各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量，将总等效生物剂量和总物理剂量以剂量体积直方图显示出来，以使得治疗医师可以根据所述剂量体积直方图评估放射治疗效果。The total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose, so that the treating physician can according to the dose volume The histogram evaluates the effects of radiation therapy.
　　需要说明的，根据CT图像和人体器官和肿瘤靶区的结构轮廓信息以及CT图像计算人体器官和肿瘤靶区的体积，然后统计出人体器官和肿瘤靶区的总等效生物剂量和总物理剂量，绘制剂量体积直方图。It should be noted that the volume of the human body and the tumor target area is calculated according to the CT image and the structural contour information of the human body and the tumor target area, and the CT image, and then the total equivalent biological dose and the total physical dose of the human body and the tumor target area are counted. , plot the dose volume histogram.
　　综上所述，本发明实施例通过接收CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，计算出单次物理剂量和对应的生物剂量值，并且形成将物理等剂量轮廓线和生物等剂量轮廓线，以使得治疗医师容易评估放射治疗的效果，解决了现有技术存在的评估方式无法准确评估放射治疗效果的问题。In summary, the embodiment of the present invention calculates a single physical dose and a corresponding biological dose value by receiving CT images, structural contour information of human organs and tumor target regions, radiation therapy dose distribution matrix, and radiation treatment plan field parameters. And forming a physical isodose contour and a biological isodose contour to make it easier for the treating physician to evaluate the effect of the radiation therapy, solving the problem that the prior art evaluation method cannot accurately evaluate the radiotherapy effect.
　　本发明实施例提供了评估放射治疗效果系统,所述评估放射治疗效果系统如图2所示,具体包括:The embodiment of the present invention provides a system for evaluating a radiotherapy effect, and the system for evaluating the radiotherapy effect is as shown in FIG. 2, and specifically includes:
　　接收单元21，用于接收输入的计算机断层扫描CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上的三维坐标数据，所述放射治疗剂量分布矩阵为经过放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵；The receiving unit 21 is configured to receive the input computed tomography CT image, the structural contour information of the human body and the tumor target area, the radiation therapy dose distribution matrix, and the radiation therapy plan field parameter, the structural contour of the human body and the tumor target area The information includes three-dimensional coordinate data of respective voxel points of the human body and the tumor target area on the CT image, and the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
　　查询单元22，用于根据CT图像、放射治疗剂量分布矩阵以及人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量；The query unit 22 is configured to query a single physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter. ;
　　计算单元23，用于根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量；The calculating unit 23 is configured to calculate an equivalent biological dose of each voxel point of the human body organ and the tumor target area according to a single physical dose of each voxel point of the human body and the tumor target area and a radiation treatment plan field parameter;
　　第一评估单元24，用于根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。The first evaluation unit 24 is configured to evaluate the radiotherapy effect according to the equivalent biological dose and the single physical dose.
　　可选的，所述查询单元22具体用于：Optionally, the query unit 22 is specifically configured to:
　　根据所述放射治疗剂量分布矩阵的三维坐标数据和三维坐标对应的总物理剂量，在CT图像上选取三维坐标与所述放射治疗剂量分布矩阵的三维坐标重合点，构建总物理剂量图像平面；Forming a total physical dose image plane according to the three-dimensional coordinate data of the radiation therapy dose distribution matrix and the total physical dose corresponding to the three-dimensional coordinates, selecting a three-dimensional coordinate coincident with the three-dimensional coordinates of the radiation therapy dose distribution matrix on the CT image;
　　根据人体器官和肿瘤靶区各个体素点在CT图像上的三维坐标数据，查询得到人体器官和肿瘤靶区各个体素点的总物理剂量；According to the three-dimensional coordinate data of the individual organ points of the human body and the tumor target area on the CT image, the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
　　根据人体器官和肿瘤靶区各个体素点的总物理剂量以及放射治疗射野参数总的治疗次数，计算得到人体器官和肿瘤靶区各个体素点的单次物理剂量。A single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
　　可选的，所述计算单元23具体用于：　　　 BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t ;Optionally, the calculating unit 23 is specifically configured to: BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t ;
　　其中，所述为人体器官和肿瘤靶区各个体素点的等效生物剂量，所述为预存的剂量效应系数，所述K为预存的剂量修正参数，所述d为人体器官和肿瘤靶区各个体素点的单次物理剂量，所述N为治疗次数，所述t为治疗之间的时间间隔，所述放射治疗计划射野参数包括治疗次数和治疗之间的时间间隔。Wherein, the equivalent biological dose of each voxel point of the human organ and the tumor target area, the pre-existing dose effect coefficient, the K being a pre-existing dose correction parameter, the d being a human organ and a tumor target area A single physical dose of each voxel point, said N being the number of treatments, said t being the time interval between treatments, said radiation therapy plan field parameters including the number of treatments and the time interval between treatments.
　　可选的，所述第一评估单元24具体用于：Optionally, the first evaluation unit 24 is specifically configured to:
　　在CT图像上分别将所述等效生物剂量值相等的点和所述单次物理剂量值相等的点连接起来，形成生物等剂量轮廓线和物理等剂量轮廓线；Connecting points equal to the equivalent biological dose value and points of the single physical dose value respectively on the CT image to form a biological isodose contour line and a physical isodose contour line;
　　将生物等剂量轮廓线和物理等剂量轮廓线显示在显示屏上，以使得治疗医师可以根据所述生物等剂量轮廓线和物理等剂量轮廓线评估放射治疗效果。A biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
　　可选的，所述系统还包括：Optionally, the system further includes:
　　第二评估单元，用于根据所述等效生物剂量值、单次物理剂量值、人体器官和肿瘤靶区的结构轮廓信息以及CT图像，计算各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量；a second evaluation unit, configured to calculate a volume of each organ and a tumor target area and a total equivalent organism according to the equivalent biological dose value, a single physical dose value, structural contour information of a human organ and a tumor target area, and a CT image Dose and total physical dose;
　　根据所述各个器官和肿瘤靶区的体积以及各个器官和肿瘤靶区的总等效生物剂量和总物理剂量，将总等效生物剂量和总物理剂量以剂量体积直方图显示出来，以使得治疗医师可以根据所述剂量体积直方图评估放射治疗效果。The total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose of each organ and tumor target area, so that treatment is performed The physician can evaluate the radiotherapy effect based on the dose volume histogram.
　　本领域普通技术人员可以理解为上述实施例所包括的各个模块只是按照功能逻辑进行划分的，但并不局限于上述的划分，只要能够实现相应的功能即可；另外，各功能模块的具体名称也只是为了便于相互区分，并不用于限制本发明的保护范围。A person skilled in the art can understand that each module included in the foregoing embodiment is only divided according to functional logic, but is not limited to the above division, as long as the corresponding function can be implemented; in addition, the specific name of each functional module It is also for convenience of distinguishing from each other and is not intended to limit the scope of protection of the present invention.
　　本领域普通技术人员还可以理解，实现上述实施例快速进入应用方法中的全部或部分步骤是可以通过程序来指令相关的硬件来完成，所述的程序可以在存储于评估放射治疗效果系统可读取存储介质中，所述的存储介质，包括ROM/RAM等。It will also be understood by those skilled in the art that all or part of the steps of implementing the above method for quickly entering the application method may be completed by a program instructing related hardware, and the program may be readable in the system for evaluating the radiotherapy effect. In the storage medium, the storage medium includes a ROM/RAM or the like.
　　以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection of the present invention. Within the scope.

Claims (10)

  1. 一种评估放射治疗效果方法，其特征在于，所述方法包括： A method for evaluating a radiotherapy effect, characterized in that the method comprises:
    　　接收输入的计算机断层扫描CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上的三维坐标数据，所述放射治疗剂量分布矩阵为经过放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵；Receiving input computed tomography CT images, structural contour information of human organs and tumor target regions, radiation therapy dose distribution matrix, and radiation therapy plan field parameters, the structural contour information of the human organs and tumor target regions including human organs and tumors The three-dimensional coordinate data of each voxel point of the target area on the CT image, the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
    　　根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗计划射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量；According to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy plan field parameters, a single physical dose of each voxel point of the human organ and the tumor target area is obtained;
    　　根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量；Calculating an equivalent biological dose of each voxel point of the human organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter;
    　　根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。The radiotherapy effect is evaluated based on the equivalent biological dose and the single physical dose.
  2. 如权利要求1所述的方法，其特征在于，所述根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的单次物理剂量具体为：The method according to claim 1, wherein said querying for human organs and tumor target regions based on CT images, radiation therapy dose distribution matrices, structural contour information of human organs and tumor target regions, and radiotherapy field parameters The single physical dose of each voxel point is specifically:
    　　根据所述放射治疗剂量分布矩阵的三维坐标数据和三维坐标对应的总物理剂量，在CT图像上选取坐标点与所述放射治疗剂量分布矩阵的坐标参数重合点，构建总物理剂量图像平面；Forming a total physical dose image plane according to the three-dimensional coordinate data of the radiation therapy dose distribution matrix and the total physical dose corresponding to the three-dimensional coordinates, selecting a coordinate point of the coordinate point and the coordinate parameter of the radiation therapy dose distribution matrix on the CT image;
    　　根据人体器官和肿瘤靶区各个体素点在CT图像上的三维坐标数据，查询得到人体器官和肿瘤靶区各个体素点的总物理剂量；According to the three-dimensional coordinate data of the individual organ points of the human body and the tumor target area on the CT image, the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
    　　根据人体器官和肿瘤靶区各个体素点的总物理剂量以及放射治疗射野参数总的治疗次数，计算得到人体器官和肿瘤靶区各个体素点的单次物理剂量。A single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
  3. 　　如权利要求1所述的方法，其特征在于，所述根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量具体为： BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t ;The method according to claim 1, wherein said calculating a body organ and a tumor target region according to a single physical dose of each voxel point of said human organ and a tumor target region and a radiation treatment plan field parameter The equivalent biological dose of the prime point is specifically: BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t ;
    　　其中，为人体器官和肿瘤靶区各个体素点的等效生物剂量，为预存的剂量效应系数，K为预存的剂量修正参数，d为人体器官和肿瘤靶区各个体素点的单次物理剂量，N为治疗次数，t为治疗之间的时间间隔，所述放射治疗计划射野参数包括治疗次数和治疗之间的时间间隔。　　Among them, the equivalent biological dose for each voxel point of human organs and tumor target area is the pre-existing dose-effect coefficient, K is the pre-existing dose-correction parameter, and d is the single-physics of each voxel point of human organs and tumor target areas. The dose, N is the number of treatments, and t is the time interval between treatments, the radiation treatment plan field parameters including the number of treatments and the time interval between treatments.
  4. 如权利要求1所述的方法，其特征在于，所述根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估具体为：The method of claim 1 wherein said evaluating said radiotherapy effect based on said equivalent biological dose and said single physical dose is:
    　　在CT图像上分别将所述等效生物剂量值相等的点和所述单次物理剂量值相等的点连接起来，形成生物等剂量轮廓线和物理等剂量轮廓线；Connecting points equal to the equivalent biological dose value and points of the single physical dose value respectively on the CT image to form a biological isodose contour line and a physical isodose contour line;
    　　将生物等剂量轮廓线和物理等剂量轮廓线显示在显示屏上，以使得治疗医师可以根据所述生物等剂量轮廓线和物理等剂量轮廓线评估放射治疗效果。A biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
  5. 　　如权利要求4所述的方法，其特征在于，所述方法还包括：The method of claim 4, wherein the method further comprises:
    　　根据所述等效生物剂量值、单次物理剂量值、人体器官和肿瘤靶区的结构轮廓信息以及CT图像，计算各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量；Calculating a volume of each organ and a tumor target area, and a total equivalent biological dose and a total physical dose according to the equivalent biological dose value, a single physical dose value, structural contour information of a human organ and a tumor target area, and a CT image;
    　　根据所述各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量，将总等效生物剂量和总物理剂量以剂量体积直方图显示出来，以使得治疗医师可以根据所述剂量体积直方图评估放射治疗效果。The total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose, so that the treating physician can according to the dose volume The histogram evaluates the effects of radiation therapy.
  6. 　　一种评估放射治疗效果系统，其特征在于，所述系统包括：A system for evaluating a radiation therapy effect, characterized in that the system comprises:
    　　接收单元，用于接收输入的计算机断层扫描CT图像、人体器官和肿瘤靶区的结构轮廓信息、放射治疗剂量分布矩阵和放射治疗计划射野参数，所述人体器官和肿瘤靶区的结构轮廓信息包括人体器官和肿瘤靶区的各个体素点在CT图像上的三维坐标数据，所述放射治疗剂量分布矩阵为经过放射治疗后，放射线在患者体内产生的物理总剂量的三维剂量分布矩阵；a receiving unit, configured to receive an input computed tomography CT image, structural contour information of a human organ and a tumor target area, a radiation therapy dose distribution matrix, and a radiation therapy plan field parameter, and structural contour information of the human body and the tumor target area The three-dimensional coordinate data of each voxel point of the human body and the tumor target area on the CT image, wherein the radiation therapy dose distribution matrix is a three-dimensional dose distribution matrix of the physical total dose generated by the radiation in the patient after the radiation treatment;
    　　查询单元，用于根据CT图像、放射治疗剂量分布矩阵、人体器官和肿瘤靶区的结构轮廓信息以及放射治疗射野参数，查询得到人体器官和肿瘤靶区各个体素点的总物理剂量；The query unit is configured to query the total physical dose of each voxel point of the human organ and the tumor target area according to the CT image, the radiation therapy dose distribution matrix, the structural contour information of the human organ and the tumor target area, and the radiation therapy field parameter;
    　　计算单元，用于根据所述人体器官和肿瘤靶区各个体素点的单次物理剂量以及放射治疗计划射野参数，计算人体器官和肿瘤靶区各个体素点的等效生物剂量；a calculating unit, configured to calculate an equivalent biological dose of each voxel point of the human body organ and the tumor target area according to a single physical dose of each voxel point of the human organ and the tumor target area and a radiation treatment plan field parameter;
    　　第一评估单元，用于根据所述等效生物剂量和所述单次物理剂量对放射治疗效果进行评估。The first evaluation unit is configured to evaluate the radiotherapy effect according to the equivalent biological dose and the single physical dose.
  7. 　　如权利要求6所述的系统，其特征在于，所述查询单元具体用于：The system of claim 6 wherein said query unit is specifically for:
    　　根据所述放射治疗剂量分布矩阵的三维坐标数据和三维坐标对应的总物理剂量，在CT图像上选取坐标点与所述放射治疗剂量分布矩阵的坐标参数重合点，构建总物理剂量图像平面；Forming a total physical dose image plane according to the three-dimensional coordinate data of the radiation therapy dose distribution matrix and the total physical dose corresponding to the three-dimensional coordinates, selecting a coordinate point of the coordinate point and the coordinate parameter of the radiation therapy dose distribution matrix on the CT image;
    　　根据人体器官和肿瘤靶区各个体素点在CT图像上的三维坐标数据，查询得到人体器官和肿瘤靶区各个体素点的总物理剂量；According to the three-dimensional coordinate data of the individual organ points of the human body and the tumor target area on the CT image, the total physical dose of each voxel point of the human organ and the tumor target area is obtained;
    　　根据人体器官和肿瘤靶区各个体素点的总物理剂量以及放射治疗射野参数总的治疗次数，计算得到人体器官和肿瘤靶区各个体素点的单次物理剂量。A single physical dose of each voxel point in the human organ and the tumor target area is calculated based on the total physical dose of each voxel point of the human organ and the tumor target area and the total number of treatments of the radiotherapy field parameters.
  8. 　　如权利要求6所述的系统，其特征在于，所述计算单元具体用于：　　 BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t;The system of claim 6 wherein said computing unit is specifically for: BED = N × d × (1+d/(α/β))/(1+2/(α/β))-K × (N-1)× t;
    　　其中，为人体器官和肿瘤靶区各个体素点的等效生物剂量，a/b为预存的剂量效应系数，K为预存的剂量修正参数，d为人体器官和肿瘤靶区各个体素点的单次物理剂量，N为治疗次数，t为治疗之间的时间间隔，所述放射治疗计划射野参数包括治疗次数和治疗之间的时间间隔。Among them, the equivalent biological dose of each voxel point of human organs and tumor target area, a/b is the pre-existing dose-effect coefficient, K is the pre-existing dose-correction parameter, and d is the voxel point of human organs and tumor target areas. A single physical dose, N is the number of treatments, and t is the time interval between treatments, the radiation treatment plan field parameters including the number of treatments and the time interval between treatments.
  9. 　　如权利要求6所述的系统，其特征在于，所述第一评估单元具体用于：The system of claim 6 wherein said first evaluation unit is specifically for:
    　　在CT图像上分别将所述等效生物剂量值相等的点和所述单次物理剂量值相等的点连接起来，形成生物等剂量轮廓线和物理等剂量轮廓线；Connecting points equal to the equivalent biological dose value and points of the single physical dose value respectively on the CT image to form a biological isodose contour line and a physical isodose contour line;
    　　将生物等剂量轮廓线和物理等剂量轮廓线显示在显示屏上，以使得治疗医师可以根据所述生物等剂量轮廓线和物理等剂量轮廓线评估放射治疗效果。A biological isodose contour and a physical isodose contour are displayed on the display screen such that the treating physician can evaluate the radiotherapy effect based on the biological isodose contour and the physical isodose contour.
  10. 　　如权利要求9所述的评估放射治疗效果系统，其特征在于，所述系统还包括:The system for evaluating a radiation therapy effect according to claim 9, wherein the system further comprises:
    　　第二评估单元，用于根据所述等效生物剂量值、单次物理剂量值、人体器官和肿瘤靶区的结构轮廓信息以及CT图像，计算各个器官和肿瘤靶区的体积以及总等效生物剂量和总物理剂量；a second evaluation unit, configured to calculate a volume of each organ and a tumor target area and a total equivalent organism according to the equivalent biological dose value, a single physical dose value, structural contour information of a human organ and a tumor target area, and a CT image Dose and total physical dose;
    　　根据所述各个器官和肿瘤靶区的体积以及各个器官和肿瘤靶区的总等效生物剂量和总物理剂量，将总等效生物剂量和总物理剂量以剂量体积直方图显示出来，以使得治疗医师可以根据所述剂量体积直方图评估放射治疗效果。 The total equivalent biological dose and the total physical dose are displayed in a dose volume histogram according to the volume of each organ and tumor target area and the total equivalent biological dose and total physical dose of each organ and tumor target area, so that treatment is performed The physician can evaluate the radiotherapy effect based on the dose volume histogram.
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111388879A (en) * 2020-03-19 2020-07-10 上海联影医疗科技有限公司 Radiation dose determination system, radiation dose determination device and storage medium
WO2020185659A1 (en) * 2019-03-08 2020-09-17 Varian Medical Systems, Inc. System and method for biological treatment planning and decision support
US11103727B2 (en) 2019-03-08 2021-08-31 Varian Medical Systems International Ag Model based PBS optimization for flash therapy treatment planning and oncology information system
CN114155934A (en) * 2021-12-10 2022-03-08 中南大学 Tumor intensity modulated radiotherapy dose prediction method based on deep learning
CN117379709A (en) * 2023-12-08 2024-01-12 中国人民解放军空军特色医学中心 Radiotherapy positioning system

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105031820B (en) * 2015-09-01 2018-04-03 上海联影医疗科技有限公司 Intensity modulated radiation therapy reverse optimization method and device
US10143859B2 (en) * 2016-09-22 2018-12-04 Varian Medical Systems International Ag Controlling and shaping the dose distribution outside treatment targets in external-beam radiation treatments
EP3539616A1 (en) * 2018-03-13 2019-09-18 Koninklijke Philips N.V. Optimizing fractionation schemes in radiation therapy using biological impact calculation
CN108310682B (en) * 2018-03-16 2022-10-18 深圳市医诺智能科技发展有限公司 Error verification method for radiotherapy dosage
CN109528202B (en) * 2018-11-14 2021-07-16 北京大学第一医院 Head and neck radiotherapy diagnosis and treatment system
CN111863203A (en) * 2020-07-20 2020-10-30 上海联影医疗科技有限公司 Method, device, equipment and storage medium for classifying radiotherapy data
CN112221023B (en) * 2020-09-27 2023-12-15 中国辐射防护研究院 Dosage evaluation system and method for radiopharmaceuticals
CN112618970B (en) * 2021-01-06 2022-03-15 南京航空航天大学 Device and medium for boron neutron capture treatment biological dose calculation method
CN113139948B (en) * 2021-04-28 2023-06-27 福建自贸试验区厦门片区Manteia数据科技有限公司 Organ contour line quality assessment method, device and system
CN113262390B (en) * 2021-06-28 2022-06-21 真实维度科技控股(珠海)有限公司 Tumor radiotherapy effect evaluation method based on radioactive particle implantation
CN114842917B (en) * 2022-03-17 2024-04-19 华中农业大学 Method for measuring and calculating radiation biological effect and equivalent biological dose
CN115120891B (en) * 2022-06-13 2023-04-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） Dose transmission evaluation device, computer-readable storage medium and system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6167294A (en) * 1996-03-29 2000-12-26 Busch; Martin Method and apparatus for producing benefit/risk evaluation data relating to radiation therapy in patients
CN101295400A (en) * 2008-06-18 2008-10-29 山东大学 Medical image partitioning method for radiation therapy planning system
US20110060602A1 (en) * 2009-09-09 2011-03-10 Grudzinski Joseph J Treatment Planning System For Radiopharmaceuticals
WO2012032609A1 (en) * 2010-09-07 2012-03-15 独立行政法人放射線医学総合研究所 Treatment planning method, treatment planning device, treatment planning program and method for calculating relative biological effectiveness
CN102671309A (en) * 2011-03-17 2012-09-19 西门子公司 Method and device for determining an irradiation plan

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101005874B (en) * 2004-08-13 2015-05-20 皇家飞利浦电子股份有限公司 Radiotherapeutic treatment plan adaptation
EP1907968A4 (en) * 2005-07-22 2009-10-21 Tomotherapy Inc Method and system for evaluating quality assurance criteria in delivery of a treament plan
WO2010068744A2 (en) * 2008-12-11 2010-06-17 Mount Sinai School Of Medicine Of New York University System and method for generating hybrid bed contour maps
CN102024097A (en) * 2010-12-29 2011-04-20 深圳市海博科技有限公司 Target spot layout optimization method in treatment plan and treatment plan system
CN102136041B (en) * 2011-04-18 2017-04-26 深圳市海博科技有限公司 Treatment plan system
CN102274588A (en) * 2011-05-25 2011-12-14 深圳市一体医疗科技股份有限公司 method and system for controlling radiation dose
JP5665994B2 (en) * 2011-08-17 2015-02-04 三菱電機株式会社 Skin dose evaluation support device and treatment planning device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6167294A (en) * 1996-03-29 2000-12-26 Busch; Martin Method and apparatus for producing benefit/risk evaluation data relating to radiation therapy in patients
CN101295400A (en) * 2008-06-18 2008-10-29 山东大学 Medical image partitioning method for radiation therapy planning system
US20110060602A1 (en) * 2009-09-09 2011-03-10 Grudzinski Joseph J Treatment Planning System For Radiopharmaceuticals
WO2012032609A1 (en) * 2010-09-07 2012-03-15 独立行政法人放射線医学総合研究所 Treatment planning method, treatment planning device, treatment planning program and method for calculating relative biological effectiveness
CN102671309A (en) * 2011-03-17 2012-09-19 西门子公司 Method and device for determining an irradiation plan

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
WANG, YULONG ET AL.: "Deviations of Planning Target Dose in Radiotherapy for Nasopharyngeal Carcinoma", J SHANXI MED UNIV, vol. 41, no. 4, 30 April 2010 (2010-04-30), pages 312 - 314 *
XIAO, GANG ET AL.: "A Survey of BNCT Treatment Planning System", CHINESE JOURNAL OF MEDICAL PHYSICS, vol. 23, no. 1, 31 January 2006 (2006-01-31), pages 5 - 6 *
ZENG, ZILI ET AL.: "Dose Calculation of Spinal Cord in Three Dimensional Conformal Radiotherapy of Lung Cancer", CHINESE JOURNAL OF MEDICAL PHYSICS, vol. 28, no. 6, 30 November 2011 (2011-11-30), pages 2978 - 2979 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020185659A1 (en) * 2019-03-08 2020-09-17 Varian Medical Systems, Inc. System and method for biological treatment planning and decision support
US11090508B2 (en) 2019-03-08 2021-08-17 Varian Medical Systems Particle Therapy Gmbh & Co. Kg System and method for biological treatment planning and decision support
US11103727B2 (en) 2019-03-08 2021-08-31 Varian Medical Systems International Ag Model based PBS optimization for flash therapy treatment planning and oncology information system
CN111388879A (en) * 2020-03-19 2020-07-10 上海联影医疗科技有限公司 Radiation dose determination system, radiation dose determination device and storage medium
CN114155934A (en) * 2021-12-10 2022-03-08 中南大学 Tumor intensity modulated radiotherapy dose prediction method based on deep learning
CN114155934B (en) * 2021-12-10 2024-05-14 中南大学 Tumor intensity modulated radiotherapy dosage prediction method based on deep learning
CN117379709A (en) * 2023-12-08 2024-01-12 中国人民解放军空军特色医学中心 Radiotherapy positioning system
CN117379709B (en) * 2023-12-08 2024-02-23 中国人民解放军空军特色医学中心 Radiotherapy positioning system

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