WO2014168105A1

WO2014168105A1 - Cephem compound having carboxy bioisostere in position 4

Info

Publication number: WO2014168105A1
Application number: PCT/JP2014/060058
Authority: WO
Inventors: 康宏西谷; 秀則吉澤
Original assignee: 塩野義製薬株式会社
Priority date: 2013-04-09
Filing date: 2014-04-07
Publication date: 2014-10-16

Abstract

A compound represented by formula (I) (In the formula, W is -CH₂-, etc., U is -S-, etc., R¹ is a substituted or unsubstituted carbocyclic group, etc., R^2A and R^2B together form an oxo, a substituted or unsubstituted methylidyne or a substituted or unsubstituted hydroxyimino, R³ is a hydrogen atom, etc., R¹¹ is a carboxy cyclic bioisostere, L is -CH₂-, etc., G is a single bond, etc., and R²⁰ is formula (Ia) and (Ib) in the specification.) or a pharmaceutically acceptable salt thereof.

Description

Cephem compound with carboxy bioisostere in position 4

The present invention relates to a cephem compound which is a cyclic bioisostere having a carboxyl at the 4-position. Specifically, the present invention relates to a cephem compound having a broad antibacterial spectrum and exhibiting strong antibacterial activity particularly against gram-positive bacteria such as penicillin-resistant pneumococci (PRSP) and particularly β-lactamase-producing gram-negative bacteria, and The present invention relates to a pharmaceutical composition containing

So far, various β-lactam drugs have been developed, and β-lactam drugs have become clinically very important antibacterial drugs. However, an increasing number of bacterial strains have acquired resistance to β-lactam drugs by producing β-lactamase that degrades β-lactam drugs.

According to Ambler's molecular classification method, β-lactamases are roughly classified into four classes. That is, class A (TEM type, SHV type, CTX-M type, KPC type, etc.), class B (IMP type, VIM type, L-1 type, etc.), class C (AmpC type, etc.), class D (OXA type, etc.) Etc.). Of these, class A, C, and D types are broadly classified into serine-β-lactamases, while class B types are broadly classified into metallo-β-lactamases, which are known to hydrolyze β-lactam drugs by different mechanisms. ing.

In recent years, the production of class A type substrate-specific extended β-lactamase (ESBL), class D serine-β-lactamase, and class B type metallo-β-lactamase has led to a large number of β-, including cephem and carbapenem. The presence of Gram-negative bacteria highly resistant to lactams is becoming a clinical problem. In particular, ESBL-producing bacteria have become a major problem in Japan and overseas as one of the causes of nosocomial infections.

As commercially available β-lactam antibacterial agents having a cephem skeleton, for example, ceftriaxone, cefcapene pivoxil, cefditorene, ceftobiprole, ceftaroline and the like are known, and these all have a carboxy at the 4-position of cephem. Alternatively, β-lactamase producing bacteria that are resistant to these drugs and that are esters thereof have been reported.

Patent Document 1 describes a compound having a carboxy bioisostere, such as phosphoric acid, phosphate ester, sulfonic acid amide, etc., at the 4-position of cephem, but a compound having a cyclic bioisostere such as tetrazolyl is Not listed. There is also no data on antibacterial activity.

Non-Patent Documents 2, 3 and 4 describe penicillin compounds having tetrazolyl at the 3-position of the penicillin skeleton, and Non-Patent Document 5 indicates that the compounds have stability against β-lactamase. Although described, a cephem compound having a tetrazolyl group at the 4-position of the cephem skeleton is not described.
Patent Documents 2, 3, 4 and Non-Patent Document 1 describe cephem compounds having tetrazolyl at the 4-position, but the structures of the 3- and / or 7-position side chains are different from the compounds of the present invention.

Patent Documents 5 and 6 describe cephem compounds having a carboxy bioisostere such as tetrazolyl at the 4-position and a cyclic quaternary ammonium group and a catechol-type substituent at the 3-position side chain. The compound of the present invention does not have the same type of 3-position side chain.

Japanese Published Patent Publication Showa 49-094697 U.S. Pat. No. 4,039,532 U.S. Pat. No. 3,966,719 European Patent Application Publication No. 207447 International Publication No. 2012/147773 International Publication No. 2013/2215

The present invention provides cephem compounds that exhibit a strong antibacterial spectrum against various bacteria including gram negative and gram positive bacteria.
Preferably, a cephem compound exhibiting strong antibacterial activity against β-lactamase-producing gram-negative bacteria is provided. More preferably, a cephem compound exhibiting strong antibacterial activity against multidrug-resistant bacteria, particularly substrate-specific extended β-lactamase (ESBL) -producing bacteria is provided. More preferably, it provides a cephem compound that exhibits effective antibacterial activity against class B metallo-β-lactamase producing Gram-negative bacteria. Particularly preferably, a cephem compound having an antibacterial action is provided against a resistant strain of a cephem compound having a carboxyl group at the 4-position.

The present invention provides the following cephem compound that solves the above-mentioned problems by having a structural feature that is a cyclic bioisostere having at least 4-position of carboxy.

(Item 1)
Formula (I):

(Where
W is —CH ₂ —, —S— or —O—,
a) when W is —CH ₂ —, U is —CH ₂ —, —S—, —S (═O) — or —O—, or b) W is —S— or —O—. When U is —CH ₂ —;
L is a single _{_{bond, -CH 2 -, - CH =}} CH -, - S -, - CH 2 -S -, - CH = CH-S -, - CH = CH-CH 2 -S-, and the following formula :

Wherein Y ¹ and Y ² are each independently —CR ⁴ R ⁵ —, —C (═O) —, —NR ⁴ —, —O— or —S (═O) ₂ — ⁴ and R ⁵ are each independently a hydrogen atom, substituted or unsubstituted lower alkyl or halogen, and n is an integer of 1 to 3.
A group selected from
G is a single bond or a substituted or unsubstituted heterocyclic group,
R ¹ is a substituted or unsubstituted carbocyclic group or a substituted or unsubstituted heterocyclic group;
R ^2A and R ^2B together form oxo, substituted or unsubstituted methylidene, or substituted or unsubstituted hydroxyimino;
R ³ is a hydrogen atom, —OCH ₃ or —NH—CH (═O),
R ¹¹ is a carboxy cyclic bioisostere;
R ²⁰ represents the following formulas (Ia) and (Ib):

Wherein R ^10a is a hydrogen atom, halogen, hydroxy, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted Lower alkoxy, substituted or unsubstituted acyl, substituted or unsubstituted carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted acyloxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aromatic carbocyclic A group, a substituted or unsubstituted non-aromatic heterocyclic group or a substituted or unsubstituted aromatic heterocyclic group,
E is the formula:

(In the formula, the bond from the cationic nitrogen atom indicates the bond with R ^10b , the other bond indicates the bond with G, and the broken line indicates a single bond between the cationic nitrogen atom and the adjacent atom. Or a lower alkylene between a cationic nitrogen atom and a ring member atom other than an adjacent atom.)
A divalent heterocyclic group containing a substituted or unsubstituted saturated or unsaturated monocyclic or condensed quaternary ammonium ion, wherein R ^10b is a substituted or unsubstituted amino, substituted Or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, or substituted or unsubstituted lower alkoxy)
Is a group selected from
However, the following:
1) Compounds (A-1) and (A-3):

and,
2) L is _{-S -, - CH 2 -S -} , - CH = CH-S- or _{-CH = CH-CH 2 -S-,} G is a single ^{bond, R 20} is formula (Ib), and, E Is a mono- or fused-ring pyridinium substituted with at least two adjacent hydroxys:
except for. )
Or a pharmaceutically acceptable salt thereof.

(Item 2)
R ¹ is the formula:

(Wherein X is N, C (—H) or C (—R ¹² ), and R ¹² is halogen)
Or a pharmaceutically acceptable salt thereof.

(Item 3)
2. The compound according to item 1, or a pharmaceutically acceptable salt thereof, wherein X is C (—H) or C (—Cl).

(Item 4)
R ^2A and R ^{2B taken} together are oxo, substituted methylidene as shown below:

(Wherein R ¹⁴ is substituted or unsubstituted lower alkyl, and the wavy bond means cis, trans, or a mixture thereof)
Or a substituted or unsubstituted hydroxyimino as shown below:

(Wherein R ⁹ is a hydrogen atom or a substituted or unsubstituted lower alkyl)
The compound or the pharmaceutically acceptable salt thereof according to any one of items 1 to 3, wherein

(Item 5)
R ^2A and R ^{2B taken} together form the substituted hydroxyimino shown below

Wherein R ⁷ and R ⁸ are each independently a hydrogen atom, halogen, hydroxy, carboxy, substituted or unsubstituted lower alkyl, substituted or unsubstituted carbocyclic group, or substituted or unsubstituted heterocyclic Or R ⁷ and R ⁸ together with adjacent atoms may form a substituted or unsubstituted carbocyclic ring or a substituted or unsubstituted heterocyclic ring,
Q is a single bond, a substituted or unsubstituted carbocycle, or a substituted or unsubstituted heterocycle,
m represents an integer of 0 to 3)
Or

The compound according to any one of Items 1 to 3, or a pharmaceutically acceptable salt thereof.

(Item 6)
R ^2A and R ^2B together are substituted methylidene as shown below:

(Wherein the wavy bond means cis, trans, or a mixture thereof)
The compound according to any one of Items 1 to 3, or a pharmaceutically acceptable salt thereof.

(Item 7)
7. The compound according to any one of items 1 to 6, or a pharmaceutically acceptable salt thereof, wherein R ³ is a hydrogen atom or —OCH ₃ .

(Item 8)
The R ¹¹ carboxy cyclic bioisostere has the formula:

(In the formula, R ¹³ is a group having an electron-withdrawing property)
8. The compound according to any one of items 1 to 7, or a pharmaceutically acceptable salt thereof, selected from

(Item 9)
Carboxy cyclic bioisosteres have the formula:

8. The compound according to any of items 1 to 7, or a pharmaceutically acceptable salt thereof, which is a group represented by:

(Item 10)
R ²⁰ represents formula (Ia):

10. The compound according to any one of items 1 to 9, or a pharmaceutically acceptable salt thereof.

(Item 11)
R ²⁰ represents formula (Ib):

(Item 12)
Item 12. The compound according to any one of items 1 to 9, or a pharmaceutically acceptable salt thereof, wherein E is a divalent group containing a substituted or unsubstituted monocyclic or condensed pyridinium.

(Item 13)
E is the formula:

(In the formula, one or more substituents selected from halogen, lower alkyl, and lower alkoxy may be the same or different on the ring.)
12. The compound according to any one of items 1 to 9, or a pharmaceutically acceptable salt thereof, which is a group selected from:

(Item 14)
E is the formula:

(In the formula, one or more substituents selected from halogen, lower alkyl, and lower alkoxy may be the same or different on the ring.)
The compound according to any one of items 1 to 9, 11 or a pharmaceutically acceptable salt thereof, which is a group represented by:

(Item 15)
R ^10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted ethyl, substituted or unsubstituted methoxy, substituted or unsubstituted ethoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy Substituted or unsubstituted aminomethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, substituted or unsubstituted carbamoylethyl, substituted or unsubstituted piperazylcarbonylmethyl, substituted or unsubstituted morpholine Nylcarbonylmethyl, substituted or unsubstituted piperazylcarbonylethyl, substituted or unsubstituted morpholinylcarbonylethyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted dihydropyrimimi Dinyl, substituted or unsubstituted dihydropyridanidyl, substituted or unsubstituted quinolyl, substituted or unsubstituted phenyl, substituted or unsubstituted pyridyl, substituted or unsubstituted pyrimidyl, substituted or unsubstituted pyridazyl, substituted or unsubstituted Substituted pyrazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted dihydrooxazolyl, substituted or unsubstituted oxadiazolyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted dihydroimidazolyl, Substituted or unsubstituted isothiazolyl, substituted or unsubstituted isoxadiazolyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted tetra A dihydrothiazolyl Lil, or a substituted or unsubstituted compound or a pharmaceutically acceptable salt thereof, according to any of items 1-10.

(Item 16)
R ^10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy substituted or unsubstituted aminoethyl, substituted or unsubstituted pyrrolyl Substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, substituted Or the compound according to any one of Items 1 to 10, or a pharmaceutically acceptable salt thereof, which is unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl.

(Item 17)
R ^10b is substituted or unsubstituted methyl, substituted or unsubstituted ethyl, substituted or unsubstituted aminomethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, substituted or unsubstituted carbamoylethyl, substituted Or an unsubstituted piperazylcarbonylmethyl, a substituted or unsubstituted morpholinylcarbonylmethyl, a substituted or unsubstituted piperazinylcarbonylethyl, or a substituted or unsubstituted morpholinylcarbonylethyl, 15. The compound according to any one of to 14, or a pharmaceutically acceptable salt thereof.

(Item 18)
Any one of Items 1 to 9, 11 to 14 wherein R ^10b is substituted or unsubstituted ethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, or substituted or unsubstituted piperazinylcarbonylmethyl Or a pharmaceutically acceptable salt thereof.

(Item 19)
19. The compound according to any one of items 1 to 18, or a pharmaceutically acceptable salt thereof, wherein W is —CH ₂ —.

(Item 20)
20. The compound according to any one of items 1 to 19, or a pharmaceutically acceptable salt thereof, wherein U is —S— or —O—.

(Item 21)
L is a single bond, —CH ₂ —, —CH═CH—, —S—, —CH ₂ —S— or the following formula:

The compound according to any one of Items 1 to 20, or a pharmaceutically acceptable salt thereof, which is a group represented by:

(Item 22)
G is a single bond or formula:

The compound according to any one of Items 1 to 21, or a pharmaceutically acceptable salt thereof, which is a group represented by:

(Item 23)
W is —CH ₂ —;
U is -S- or -O-;
L is a single bond, —CH ₂ —, —CH═CH—, —S—, —CH ₂ —S— or the following formula:

A group represented by
G is a single bond or formula:

A group represented by
R ¹ is the formula:

(Wherein X is N, C (—H) or C (—R ¹² ), and R ¹² is halogen)
A group represented by
R ^2A and R ^{2B taken} together are oxo, substituted methylidene as shown below:

(Wherein R ⁹ is a hydrogen atom or a substituted or unsubstituted lower alkyl)
And
R ³ is a hydrogen atom or -OCH _3,
R ¹¹ represents the formula:

A group represented by
R ^10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aminoethyl, substituted or unsubstituted Pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, Substituted or unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl,
E is a divalent group containing substituted or unsubstituted pyridinium;
Item 10. The compound according to Item 1, or a pharmaceutically acceptable salt thereof, wherein R ^10b is substituted or unsubstituted ethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, or substituted or unsubstituted piperazinylcarbonylmethyl Salt.

(Item 24)
W is —CH ₂ —;
U is -S- or -O-;
L is a single bond, —CH ₂ —, —CH═CH—, —S—, —CH ₂ —S— or the following formula:

A group represented by
G is a single bond or formula:

A group represented by
R ¹ is the formula:

A group represented by
R ²⁰ is R ^10a ;
R ^10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aminoethyl, substituted or unsubstituted Pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, The compound of item 1, which is substituted or unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl, or a pharmaceutically acceptable salt thereof

(Item 25)
formula:

Item 1. The compound according to Item 1, selected from: or a pharmaceutically acceptable salt thereof.

(Item 26)
26. A pharmaceutical composition comprising the compound according to any one of items 1 to 25, or a pharmaceutically acceptable salt thereof.

(Item 27)
27. A pharmaceutical composition according to item 26, which has an antibacterial action.

(Item 28)
The compound according to any one of items 1 to 25 or a pharmaceutically acceptable salt thereof for the treatment and / or prevention of an infectious disease.

(Item 29)
26. A method for treating and / or preventing an infectious disease, comprising administering the compound according to any one of items 1 to 25, or a pharmaceutically acceptable salt thereof.

The compound according to the present invention is useful as a pharmaceutical in that it has at least one of the following characteristics.
1) It exhibits a strong antibacterial spectrum against various bacteria including Gram negative bacteria and / or Gram positive bacteria.
2) Strong antibacterial activity against β-lactamase-producing gram-negative bacteria.
3) Strong antibacterial activity against multi-drug resistant bacteria, especially class B type metallo-β-lactamase producing Gram-negative bacteria.
4) It shows strong antibacterial activity against substrate-specific extended β-lactamase (ESBL) -producing bacteria including SHV and KPC.
5) No cross-resistance with existing cephem and / or carbapenem drugs.
6) Does not show side effects such as fever after in vivo administration.
7) High stability and / or solubility in water of the compound.
8) It has excellent pharmacokinetic characteristics such as high blood concentration, high oral absorption, long duration of effect, and high tissue migration.
In addition, the compound of the present invention has a carboxy cyclic bioisostere introduced at the 4-position although it does not have a catechol group that is usually advantageous for anti-gram-negative bacterial activity on the 3-position side chain. In particular, the activity of anti-gram-negative bacteria is improved.

Hereinafter, embodiments of the present invention will be described. Throughout this specification, singular forms (eg, “a”, “an”, “the” in English, corresponding articles in other languages, adjectives, etc.) It should be understood that it also includes the plural concept. In addition, it is to be understood that the terms used in the present specification are used in the meaning normally used in the art unless otherwise specified. Thus, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control. Hereinafter, specific definitions of terms specifically used in the present specification will be described.

Each term in this specification is defined as follows, alone or in combination with other terms.

“Halogen” includes fluorine, chlorine, bromine and iodine. Preferred are fluorine, chlorine and bromine, and more preferred is chlorine.

The “lower alkyl group” includes a linear or branched alkyl group having 1 to 8, preferably 1 to 6, and more preferably 1 to 4 carbon atoms. For example, methyl, ethyl, n-propyl Isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl and the like.

The “lower alkylene group” includes a linear alkylene group having 1 to 8, preferably 1 to 6, more preferably 1 to 4, and most preferably 1 or 2 carbon atoms, such as methylene, ethylene, n -Propylene, n-butylene, n-pentylene, n-hexylene and the like.

The “lower alkenylene group” includes a linear alkenylene group having 2 to 8, preferably 2 to 6, and more preferably 2 to 4 carbon atoms having one or more double bonds at any position. Examples include vinylene, arylene, propenylene, butenylene, plenylene, butadienylene, pentenylene, pentadienylene, hexenylene, hexadienylene, and the like.

The “lower alkynylene group” includes a straight-chain alkynylene group having 2 to 8, preferably 2 to 6, and more preferably 2 to 4 carbon atoms having one or more triple bonds at any position. Ethynylene, propynylene, butynylene, pentynylene, hexynylene and the like.

The “halo lower alkyl group” is a group substituted with one or more “halogen” at any position of the “lower alkyl group”, and examples thereof include monofluoromethyl, difluoromethyl, trifluoromethyl, monochloro Examples include methyl, dichloromethyl, trichloromethyl, monobromomethyl, monofluoroethyl, monochloroethyl, chlorodifluoromethyl and the like. Preferred are trifluoromethyl and trichloromethyl.

As a substituent of the “substituted or unsubstituted amino group” or “substituted or unsubstituted carbamoyl group”,
Substituted or unsubstituted lower alkyl (eg, methyl, ethyl, isopropyl, benzyl, carbamoylalkyl (eg, carbamoylmethyl), mono- or di-lower alkylcarbamoyl lower alkyl (eg, dimethylcarbamoylethyl), hydroxy lower alkyl, heterocyclic lower Alkyl (eg morpholinylethyl, tetrahydropyranylethyl), alkoxycarbonyl lower alkyl (eg ethoxycarbonylmethyl, ethoxycarbonylethyl), mono- or di-lower alkylamino lower alkyl (eg dimethylaminoethyl);
Lower alkoxy lower alkyl (eg, methoxyethyl, ethoxymethyl, ethoxyethyl, isopropoxyethyl));
Acyl (eg, formyl, substituted or unsubstituted lower alkylcarbonyl (eg, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, octanoyl, methoxyethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, Alkoxycarbonylacetyl (eg ethoxycarbonylmethylcarbonyl), lower alkoxy lower alkylcarbonyl (eg methoxyethylcarbonyl), lower alkylcarbamoyl lower alkylcarbonyl (eg methylcarbamoylethylcarbonyl)), substituted or unsubstituted lower alkenylcarbonyl, Substituted or unsubstituted lower alkynylcarbonyl, substituted or unsubstituted arylcarbonyl (eg benzoyl, toluoyl), substituted or unsubstituted Aromatic carbocyclic carbonyl (eg cyclopropylcarbonyl), substituted or unsubstituted heteroarylcarbonyl (eg pyridylcarbonyl), substituted or unsubstituted non-aromatic heterocyclic carbonyl (eg piperazinylcarbonyl, morpholinyl) Carbonyl));
Substituted or unsubstituted arylalkyl (eg benzyl, 4-fluorobenzyl);
Hydroxy;
Substituted or unsubstituted lower alkylsulfonyl (eg, methanesulfonyl, ethanesulfonyl, isopropylsulfonyl, 2,2,2-trifluoroethanesulfonyl, benzylsulfonyl, methoxyethylsulfonyl);
Arylsulfonyl optionally having lower alkyl or halogen as a substituent (eg, benzenesulfonyl, toluenesulfonyl, 4-fluorobenzenesulfonyl);
Cycloalkyl (eg, cyclopropyl);
Aryl optionally having lower alkyl as a substituent (eg, phenyl, tolyl);
Lower alkylaminosulfonyl (eg, methylaminosulfonyl, dimethylaminosulfonyl);
Lower alkylaminocarbonyl (eg, dimethylaminocarbonyl);
Lower alkoxycarbonyl (eg ethoxycarbonyl);
Cycloalkylcarbonyl (eg, cyclopropylcarbonyl, cyclohexylcarbonyl);
Substituted or unsubstituted sulfamoyl (eg, sulfamoyl, methylsulfamoyl, dimethylsulfamoyl);
Lower alkylcarbonylamino (eg, methylcarbonylamino);
Heterocycle (eg morpholinyl, tetrahydropyranyl);
Examples thereof include substituted or unsubstituted amino (eg, mono or dialkylamino (eg, dimethylamino), formylamino) and the like.
The “substituted amino” or “substituted carbamoyl” may be mono-substituted or di-substituted with these substituents.

“Lower alkenyl” means a linear or branched alkenyl having 2 to 8 carbon atoms having one or more double bonds to the above “lower alkyl”, for example, vinyl, 1-propenyl 2-propenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1,3-butadienyl, 3-methyl-2-butenyl and the like. Preferably, it is alkenyl having 2 to 6 carbon atoms, more preferably 2 to 4 carbon atoms.

“Lower alkynyl” means a linear or branched alkynyl having 2 to 8 carbon atoms having one or more triple bonds to the above “lower alkyl”. For example, ethynyl, propynyl, butynyl , Pentynyl, hexynyl, heptynyl, octynyl, noninyl, decynyl and the like. These may further have a double bond at an arbitrary position. Preferred is alkynyl having 2 to 6 carbon atoms, more preferably 2 to 4 carbon atoms.

The amino group of the “substituted or unsubstituted amino group” or “substituted or unsubstituted carbamoyl group” contains a sulfur atom and / or an oxygen atom in the ring together with two adjacent nitrogen atoms of the amino group. Optionally containing nitrogen-containing heterocycles (preferably 5- to 7-membered rings and preferably saturated), which rings may be substituted with oxo or hydroxy. When there is a sulfur atom forming a ring, the sulfur atom may be substituted with oxo. For example, 5-membered or 6-membered rings such as piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 4-hydroxymorpholinyl and the like are preferable.

The substituent of “substituted or unsubstituted lower alkyl”, “substituted or unsubstituted alkenyl” and “substituted or unsubstituted lower alkynyl” includes one or more groups selected from substituent group α. When substituted with a plurality of substituent groups α, the substituent groups α may be the same or different.

Examples of the substituent of “substituted or unsubstituted lower alkylene”, “substituted or unsubstituted lower alkenylene” and “substituted or unsubstituted lower alkynylene” include one or more groups selected from substituent group α. . When substituted with a plurality of substituents, the substituents may be the same or different.

The substituent of “substituted or unsubstituted aminosulfonyl” includes substituted lower alkyl and one or more groups selected from substituent group α.

The substituent of “substituted or unsubstituted lower alkyloxycarbonyl” includes one or more groups selected from substituent group α.

The substituent of “carbonyloxy having a substituent (meaning“ —O—C (═O) -substituent ”)” includes substituted or unsubstituted lower alkyl, substituted or unsubstituted lower Selected from alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted carbocyclic group, substituted or unsubstituted heterocyclic group, amino having heterocyclic group as substituent, and substituent group α One or more groups may be mentioned.
Substituents of “substituted or unsubstituted carboxy” include substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted carbocyclic group, and substituted Or one or more groups selected from an unsubstituted heterocyclic group are mentioned.
“Acyl” refers to a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted carbocyclic group or substituted or unsubstituted heterocyclic A carbonyl group substituted by a group is meant.

The “acyl” part in “acyloxy” has the same meaning as the above “acyl”.
“Substituted or unsubstituted acyloxy” is preferably substituted or unsubstituted lower alkylcarbonyloxy, substituted or unsubstituted aromatic carbocyclic carbonyloxy, substituted or unsubstituted non-aromatic carbocyclic carbonyloxy, substituted or unsubstituted Substituted heterocyclic carbonyloxy or substituted or unsubstituted non-aromatic heterocyclic carbonyloxy. More preferably, lower alkylcarbonyloxy, lower alkoxy, lower alkylcarbonyloxy, halo lower alkylcarbonyloxy, cycloalkylcarbonyloxy or 5- or 6-membered non-aromatic heterocycle that is unsubstituted or substituted with lower alkyl, halogen, or lower alkoxy. Ring carbonyloxy.

Substituents of “substituted or unsubstituted carbamoyloxy” and “substituted or unsubstituted hydroxyimino” include substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted Or an unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, an amino having a heterocyclic group as a substituent, and one or more groups selected from the substituent group α.

Examples of the substituent of “substituted or unsubstituted saturated or unsaturated monocyclic or condensed cyclic divalent heterocyclic group containing one or more quaternary ammonium ions” include substituted or unsubstituted lower alkyl, Examples thereof include substituted or unsubstituted lower alkylene, and one or more groups selected from the substituent group α, or those in which two or more substituents are combined to form a carbocyclic group or heterocyclic group. . When the substituent is lower alkylene, a quaternary ammonium group may form a crosslinked structure.

Here, the “substituent group α” is halogen, hydroxy, lower alkoxy, hydroxy lower alkoxy, lower alkoxy lower alkoxy, carboxy, amino, acylamino, lower alkylamino, imino, hydroxyimino, lower alkoxyimino, lower alkylthio, carbamoyl. , Lower alkylcarbamoyl, hydroxy lower alkylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfinyl, cyano, nitro, carbocyclic group and heterocyclic group.

“Lower alkoxy”, “hydroxy lower alkoxy”, “lower alkoxy lower alkoxy”, “lower alkylamino”, “lower alkoxyimino”, “lower alkylthio”, “lower alkylcarbamoyl”, “hydroxy lower alkylcarbamoyl”, “lower The lower alkyl moiety in “alkylsulfamoyl”, “lower alkylsulfinyl”, “lower alkyloxycarbonyl”, “lower alkylsulfonyl”, and “halo lower alkyl” is also the same as the above “lower alkyl”.
The lower alkenyl moiety in “lower alkenyloxy” has the same meaning as the above “lower alkenyl”.
The aryl moiety in “aryloxy” has the same meaning as “aryl” described later. The heteroaryl moiety in “heteroaryloxy” has the same meaning as “heteroaryl” described later.

Preferred examples of the substituent in the “substituted or unsubstituted lower alkyl” include a fluorine atom, a chlorine atom, a bromine atom, hydroxy, carboxy, methoxy, ethoxy, hydroxymethoxy, hydroxyethoxy, methoxymethoxy, methoxyethoxy, amino, and acetyl. Amino, methylamino, dimethylamino, imino, hydroxyimino, methoxyimino, methylthio, carbamoyl, methylcarbamoyl, hydroxymethylcarbamoyl, sulfamoyl, methylsulfamoyl, lower alkylsulfamoyl, cyano, nitro, phenyl, cyclopropyl, cyclobutyl Cyclohexyl, pyridyl, morpholinyl and the like.

Preferred embodiments of “substituted or unsubstituted lower alkyl” include methyl, ethyl, isopropyl, tert-butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monochloromethyl, dichloromethyl, trichloromethyl, carboxymethyl, carboxyethyl , Carbamoylmethyl, carbamoylethyl, hydroxymethyl, hydroxyethyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, methylthiomethyl, ethylthiomethyl, benzyl, phenethyl, 4-hydroxybenzyl, 4-methoxybenzyl, 4-carboxybenzyl Etc.

“Carbocyclic group” includes cycloalkyl, cycloalkenyl, aryl, non-aromatic fused carbocyclic group, and the like.

“Cycloalkyl” is a carbocyclic group having 3 to 10 carbon atoms, preferably 3 to 8 carbon atoms, more preferably 3 to 7 carbon atoms. For example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclo Includes octyl, cyclononyl, cyclodecyl and the like.

“Cycloalkenyl” includes those having one or more double bonds at any position in the cycloalkyl ring, specifically, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclo Examples include heptynyl, cyclooctynyl and cyclohexadienyl.

“Aryl” includes phenyl, naphthyl, anthryl, phenanthryl and the like, with phenyl being particularly preferred.

The “aromatic carbocyclic group” means the same group as the above aryl.
“Carbocycle” means a saturated or unsaturated cyclic hydrocarbon. A 3- to 8-membered non-aromatic carbocycle or a 6-membered or 10-membered aromatic carbocycle is preferred.
Examples of the substituent of “substituted or unsubstituted carbocycle” include substituted or unsubstituted lower alkyl and one or more groups selected from substituent group α.

“Heteroaryl” means a monocyclic or bicyclic or more aromatic cyclic group having one or more of the same or different heteroatoms arbitrarily selected from O, S and N in the ring.
The heteroaryl having two or more rings includes those obtained by condensing the above “aromatic carbocycle” to a single ring or two or more aromatic heterocycles.
The “aromatic heterocyclic group” means the same group as the above “heteroaryl”.

The “non-aromatic carbocyclic group” means a monocyclic or two or more cyclic saturated or unsaturated hydrocarbon group or a cyclic non-aromatic unsaturated hydrocarbon group. The non-aromatic carbocyclic group having 2 or more rings includes a monocyclic ring or a non-aromatic carbocyclic group having 2 or more rings condensed with the ring in the above “aromatic carbocyclic group”. Further, a group selected from the above “cycloalkyl” and “cycloalkenyl” is included. Furthermore, the group which is bridge | crosslinked as follows, or the group which forms a spiro ring is also included.

Specific examples include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptynyl, cyclooctynyl and cyclohexadienyl.
Examples of the two or more non-aromatic carbocyclic groups include indanyl, indenyl, naphthyl, tetrahydronaphthyl, fluorenyl and the like.

“Heterocyclic group” includes a heterocyclic group having one or more heteroatoms arbitrarily selected from O, S and N, specifically, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl. , Pyrimidinyl, pyrazinyl, triazolyl, triazinyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiadiazolyl, furyl, thienyl and the like; indolyl, isoindolyl, indazolyl, indolizinyl, indolinyl, isoindolinyl, quinolyl, Isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzopyranyl, benzimidazolyl, benzotriazolyl, benz Soxazolyl, benzoxazolyl, benzoxiazolyl, benzoisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, pyrazolopyridine, triazolopyridyl, imidazo Bicyclic fused heterocyclic groups such as thiazolyl, pyrazinopyridazinyl, quinazolinyl, quinolyl, isoquinolyl, naphthyridinyl, dihydrobenzofuryl, tetrahydroquinolyl, tetrahydroisoquinolyl, dihydrobenzoxazine, tetrahydrobenzothienyl; Tricyclic fused heterocyclic groups such as carbazolyl, acridinyl, xanthenyl, phenothiazinyl, phenoxathinyl, phenoxazinyl, dibenzofuryl, imidazoquinolyl; dioxanyl, thii Nil, oxiranyl, oxathiolanyl, azetidinyl, thianyl, thiazolidine, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl, thiomorpholinyl, dihydropyridyl, tetrahydropyridyl, tetrahydropyridyl, tetrahydropyridyl Includes non-aromatic heterocyclic groups such as thiazolyl, tetrahydroisothiazolyl, dihydrooxazinyl, hexahydroazepinyl, tetrahydrodiazepinyl and the like. A 5- to 6-membered heteroaryl or non-aromatic heterocyclic group is preferable. More preferred is 5- to 6-membered heteroaryl.

“Non-aromatic heterocyclic group” means a group that does not exhibit aromaticity among the above-mentioned “heterocyclic group”.

“Heterocycle” means a saturated or unsaturated cyclic group containing one or more heteroatoms arbitrarily selected from O, S and N. Preferably, it is a 3- to 8-membered non-aromatic heterocyclic ring or a 5- to 10-membered aromatic heterocyclic ring. More preferably, it is a 3- to 6-membered non-aromatic heterocyclic ring or a 5- to 6-membered aromatic heterocyclic ring.

As the substituents of “substituted or unsubstituted carbocyclic group”, “substituted or unsubstituted aromatic carbocyclic group” and “substituted or unsubstituted carbocyclic group”, substituted or unsubstituted lower alkyl and substituted One or more groups selected from the base group α can be mentioned.

The substituents of “substituted or unsubstituted heterocyclic group”, “substituted or unsubstituted aromatic heterocyclic group” and “substituted or unsubstituted heterocycle” include substituted or unsubstituted lower alkyl, oxo And one or more groups selected from the substituent group α.

Examples of the substituent of the “substituted or unsubstituted non-aromatic carbocyclic group” and “substituted or unsubstituted non-aromatic heterocyclic group” include substituted or unsubstituted lower alkyl, oxo, and substituent group α 1 or more groups selected from

"Substituted or unsubstituted carbocyclic group", "Substituted or unsubstituted heterocyclic group", "Substituted or unsubstituted carbocycle", "Substituted or unsubstituted heterocycle", "Substituted or unsubstituted heterocyclic group" "Aromatic carbocyclic group", "Substituted or unsubstituted aromatic heterocyclic group", "Substituted or unsubstituted non-aromatic carbocyclic group" and "Substituted or unsubstituted non-aromatic heterocyclic group" As a preferred embodiment of the substituent in the formula, methyl, ethyl, isopropyl, tert-butyl, fluorine atom, chlorine atom, bromine atom, oxo, hydroxyl, carboxy, methoxy, ethoxy, hydroxymethoxy, hydroxyethoxy, methoxymethoxy, methoxyethoxy , Amino, acetylamino, methylamino, dimethylamino, imino, hydroxyimino, methoxyimino, methylthio, Examples include carbamoyl, methylcarbamoyl, hydroxymethylcarbamoyl, sulfamoyl, methylsulfamoyl, ethylsulfamoyl, isopropylsulfamoyl, cyano, nitro, phenyl, cyclopropyl, cyclobutyl, cyclohexyl, pyridyl, morpholinyl and the like.

Hereinafter, preferred embodiments at each site of the formula (I) will be shown.

W is —CH ₂ —, —S— or —O—. Preferred is —CH ₂ —.

When W is —CH ₂ —, U is —CH ₂ —, —S—, —S (═O) — or —O—, preferably —S—, —O— or —S (═O ) —, More preferably —S— or —O—.

When W is —S— or —O—, U is —CH ₂ —.

L is a single _{_{bond, -CH 2 -, - CH =}} CH -, - S -, - CH 2 -S -, - CH = CH-S -, - CH = CH-CH 2 -S-, and the following formula :

Wherein Y ¹ and Y ² are each independently —CR ⁴ R ⁵ —, —C (═O) —, —NR ₄ —, —O— or —S (═O) ₂ — ⁴ and R ⁵ are each independently a hydrogen atom, substituted or unsubstituted lower alkyl or halogen, and n is an integer of 1 to 3.
Is a group selected from
L is

A preferred embodiment in the case of
Y ¹ and Y ² are preferably each independently —CR ⁴ R ⁵ — or —C (═O) —, more preferably —CR ⁴ R ⁵ —.
R ⁴ and R ⁵ are preferably each independently a hydrogen atom, a methyl atom or a fluorine atom, more preferably a hydrogen atom.
n is preferably 1 or 2, more preferably 1.
The bonding mode of the double bond between carbon atoms in L may be any of a cis bond, a trans bond, or a mixture thereof.

L is preferably a single bond, —CH ₂ —, —CH═CH—, —S—, —CH ₂ —S— or the following formula:

It is group shown by these. More preferably, L is a single bond, —CH ₂ —, —CH═CH—, —S—, —CH ₂ —S— or the following formula:

It is group shown by these.

G is a single bond or a substituted or unsubstituted heterocyclic group. The heterocyclic group is preferably a 5- to 6-membered member, and more preferably an aromatic heterocyclic group.
G is more preferably a single bond, a substituted or unsubstituted 5- to 6-membered nitrogen-containing aromatic heterocyclic group (eg, thiazolyl, thiathiazolyl, pyridyl, pyrimidyl), and more preferably a single bond or Thiazolyl. The substituent is preferably one or more groups selected from halogen, lower alkyl, halo lower alkyl, amino, hydroxy, carboxy, nitro and cyano. More preferably, they are a fluorine atom, a chlorine atom, or methyl.

Examples of the “substituted or unsubstituted carbocyclic group or substituted or unsubstituted heterocyclic group” of R ¹ include, for example, a substituted or unsubstituted aromatic carbocyclic group (eg substituted or unsubstituted Phenyl (examples of substituents: hydroxy, halogen)), substituted or unsubstituted 5- to 6-membered heterocyclic groups (eg aminothiazole, aminothiazolyl substituted with halogen, aminothiadiazolyl, thiophenyl, furyl, benzothiazolyl) , Pyridyl, pyrimidyl, pyridazyl, aminopyridyl) and the like.
Preferable examples include the groups shown below.

More preferred examples include the groups shown below.

For R ^2A and R ^2B
a) R ^2A is a hydrogen atom, substituted or unsubstituted amino, —SO ₃ H, substituted or unsubstituted aminosulfonyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted carbamoyl, hydroxy, or Carbonyloxy having a substituent, and
R ^2B is a hydrogen atom or
b) R ^2A and R ^2B together form oxo, substituted or unsubstituted methylidene, or substituted or unsubstituted hydroxyimino.
Preferably, R ^2A and R ^2B are taken together to form oxo, substituted or unsubstituted methylidene, or substituted or unsubstituted hydroxyimino.

When R ^2B is a hydrogen atom, R ^2A is preferably a hydrogen atom, substituted or unsubstituted amino, carboxy, —SO ₃ H, substituted or unsubstituted aminosulfonyl, carboxy, substituted or unsubstituted carbamoyl, hydroxy Or carbonyloxy having a substituent. For example,

Preferred examples of the substituted amino

Substituted aminosulfonyl shown below

(Wherein ring B represents a substituted or unsubstituted heterocyclic group);
Substituted carbamoyl shown below

(Wherein ring B represents a substituted or unsubstituted heterocyclic group); or substituted carbonyloxy as shown below

(In the formula, ring B represents a substituted or unsubstituted heterocyclic group)
Etc.

Alternatively, R ^2A and R ^{2B taken} together are oxo, substituted methylidene as shown below:

(Wherein R ¹⁴ is substituted or unsubstituted lower alkyl, and the wavy bond means cis, trans, or a mixture thereof) (examples of substituents: halogen, hydroxy) may be formed.
Preferably,

(The wavy bond means cis, trans, or a mixture thereof)
It is.
Here, an equation having a wavy coupling, for example:

Is the formula:

And mixtures thereof. The same applies to equations having other wavy lines coupled.

R ^2A and R ^2B are combined to form a substituted or unsubstituted hydroxyimino group shown below.

(Wherein R ⁹ is as defined above).
Preferably,

(Wherein each symbol is as defined above)
Or

It is group shown by these.

“R ⁷ and R ⁸ are each independently a hydrogen atom, halogen, hydroxy, carboxy, substituted or unsubstituted lower alkyl, substituted or unsubstituted carbocyclic group, or substituted or unsubstituted heterocyclic group. In this case, the lower alkyl preferably has 1 to 4 carbon atoms, and the carbocyclic group and the heterocyclic group are preferably 5 to 6-membered groups. Preferred substituents here are halogen, lower alkyl, carboxy, carbamoyl, hydroxy, lower alkoxy or lower alkylthio.

Examples of “R ⁷ and R ⁸ ” include hydrogen atom, fluorine atom, chlorine atom, hydroxy, carboxy, substituted or unsubstituted lower alkyl (eg, methyl, ethyl, isopropyl, tert-butyl, monofluoromethyl, difluoro Methyl, trifluoromethyl, carboxymethyl, carboxyethyl, carbamoylmethyl, carbamoylethyl, hydroxymethyl, hydroxyethyl, methoxymethyl, ethoxymethyl, methoxyethyl, ethoxyethyl, methylthiomethyl, ethylthiomethyl), substituted or unsubstituted carbon A cyclic group (eg, benzyl, 4-hydroxybenzyl, 4-methoxybenzyl, 4-carboxybenzyl, 3,4-dihydroxybenzyl, phenyl, 4-hydroxyphenyl, 3,4-dihydroxyphenyl, naphthyl, Chloropropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl,), substituted or unsubstituted heterocyclic groups (eg, pyrazinyl, triazolyl, triazinyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl) , Thiazolyl, thiadiazolyl, furyl and thienyl) and the like.

A preferred combination of R ⁷ and R ⁸ is that (R ⁷ , R ⁸ ) is (hydrogen atom, hydrogen atom), (methyl, hydrogen atom), (hydrogen atom, methyl), (methyl, methyl), (ethyl, (Hydrogen atom), (hydrogen atom, ethyl), (ethyl, ethyl), (phenyl, hydrogen atom), (hydrogen atom, phenyl), (dihydroxyphenyl, hydrogen atom), (hydrogen atom, dihydroxyphenyl), (carboxymethyl) , Hydrogen atom), (hydrogen atom, carboxymethyl), (carboxyethyl, hydrogen atom), (hydrogen atom, carboxyethyl), (hydroxyethyl, hydrogen atom), (hydrogen atom, hydroxylethyl), (carbamoylmethyl, hydrogen Atom), (hydrogen atom, carbamoylmethyl), (trifluoromethyl, hydrogen atom), (carboxy, hydrogen atom), (carbamoylethyl), (Hydrogen atom), (benzyl, hydrogen atom), (dihydroxybenzyl, hydrogen atom) and the like.

Preferable examples of the substituted hydroxyimino group include the following groups.

More preferable examples of the substituted hydroxyimino group include the following groups.

In the case where “R ⁷ and R ⁸ together with adjacent atoms form a substituted or unsubstituted carbocyclic ring or a substituted or unsubstituted heterocyclic ring”

(Wherein each symbol is as defined above)
R ⁷ and R ⁸ in the above formula may form a cycloalkane, cycloalkene, or non-aromatic heterocyclic ring which may have a group selected from the substituent group α on the ring. For example,

May have a group selected from substituent group α on the ring:

It may be.

Examples of “Q” include single bond, benzene, pyridine and the like. Particularly preferred is a single bond.

“M” is preferably an integer of 0 or 1, and an integer of 0 is particularly preferable.

Preferable examples in this aspect include the following.

As used herein, “bioisostere” refers to groups having chemical and physical similarities that result in similar biological properties. Accordingly, the “carboxy cyclic bioisostere” of the present invention means a group having a biological structure similar to that of carboxy and having a cyclic structure. The cyclic structure is directly connected to the cephem 4-position, and the ring is preferably a 4- to 6-membered substituted or unsubstituted heterocyclic group, and examples of the substituent include oxo, hydroxy, thioxo, halogen, substituted, or Unsubstituted lower alkyl (substituent examples: halogen, acyl, cyano, carbamoyl), carboxy, amino, carbamoyl, cyano, nitro, acyl, lower alkylsulfonyl, aminosulfonyl, substituted or unsubstituted hydroxyimino (substituent Examples: lower alkyl, halo lower alkyl, lower alkyl substituted with carboxy) and the like. The bioisostere preferably contains 1 to 4 N atoms as ring members. The bioisosteres specifically have the same electronic or physical properties as carboxy and have at least one, preferably 1-2, acidic protons, so that the acidity, water solubility, and A tendency similar to that of carboxy is expected in terms of physical properties such as pharmacokinetics. The acidic proton moiety may form a salt (eg, alkali metal salt (eg, Na salt)). They are described, for example, in J. Org. Med. Chem. 1992, 35, 1176-1183; Med. Chem. 1993, 36, 2485-2493, J. MoI. Med. Chem. 1992, 35, 3691-3698, J. MoI. Med. Chem. 1995, 38, 617-628, Med. Res. Rev. 1983, 3, 91-118; Med. Chem. 2001, 44, 1560-1563, Bioorganic & Medicinal Chemistry Letters, Vol. 4, no. 1, 41-44, 1994, and the like. The bioisostere is preferably selected from the group consisting of:

(In the formula, R ¹³ is an electron-withdrawing group.)
Preferred examples of the electron withdrawing group include halo lower alkyl, halogen, carbamoyl, cyano, nitro, acyl, lower alkylsulfonyl, aminosulfonyl, substituted or unsubstituted hydroxyimino, and the like. Particularly preferred examples include a fluorine atom, —CHF ₂ , —CF ₃ , —CONH ₂ , —CN, —C═N—OH, —SO ₂ CH ₃ or —SO ₂ NH ₂ .
More preferably, the bioisostere is

It is.

“R ³ ” is preferably a hydrogen atom or —OCH ₃ , more preferably a hydrogen atom.

E is the formula:

(In the formula, the bond from the cationic nitrogen atom indicates the bond with R ^10b , the other bond indicates the bond with G, and the broken line indicates a single bond between the cationic nitrogen atom and the adjacent atom. Or a lower alkylene between a cationic nitrogen atom and a ring member atom other than an adjacent atom.)
And a divalent heterocyclic group containing a substituted or unsubstituted saturated or unsaturated monocyclic or condensed quaternary ammonium ion. In the heterocyclic group, the cationic nitrogen atom is present only at the binding site with R ^10b . The heterocyclic group is preferably a 6 to 10 membered ring, more preferably the following formula:

(Wherein the bond from the cationic nitrogen atom represents a bond with R ^10b and the other bond represents a bond with G), and further has a substituent on the ring. A good group. Except when the substituent is at least two adjacent hydroxy. Examples of the substituent on the ring include substituted or unsubstituted lower alkyl or one or more groups selected from the same or different groups selected from the substituent group α. Preferred embodiments of the substituent on the ring include lower alkyl (eg, methyl, ethyl, isopropyl, tert-butyl), halogen (eg, fluorine atom, chlorine atom, bromine atom), carboxy, substituted or unsubstituted lower alkoxy. (Eg, methoxy, ethoxy, hydroxymethoxy, hydroxyethoxy, methoxymethoxy, methoxyethoxy), substituted or unsubstituted amino (eg, amino, acetylamino, methylamino, dimethylamino), substituted or unsubstituted imino (eg: Imino, hydroxyimino, methoxyimino), lower alkylthio (eg, methylthio), substituted or unsubstituted carbamoyl (eg, carbamoyl, methylcarbamoyl, hydroxymethylcarbamoyl), substituted or unsubstituted sulfamoyl (eg, sulfamoyl, methyl) Sulfamoyl, ethylsulfamoyl), cyano, nitro, carbocyclic group (eg, phenyl, cyclopropyl, cyclobutyl, cyclohexyl), heterocyclic group (eg, pyridyl, morpholinyl) and the like. A more preferred embodiment is an unsubstituted cyclic group, or a cyclic group mono- or di-substituted with a fluorine atom, a chlorine atom or methoxy. A particularly preferred embodiment is an unsubstituted cyclic group.

As a more preferred example of E, the formula:

(In the formula, the bond from the cationic nitrogen atom represents the bond to R ^10b , the other bond represents the bond to G, and the substituted or unsubstituted lower alkyl, halogen, lower alkoxy on the ring. , Optionally having one or more groups selected from substituted or unsubstituted amino, cyano and nitro. The pyridine ring is preferably unsubstituted.

R ^10a is a hydrogen atom, halogen, hydroxy, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, Substituted or unsubstituted acyl, substituted or unsubstituted carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted acyloxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted non-aromatic carbocyclic group, substituted Or an unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group. Preferably, a hydrogen atom, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted acyloxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted 5 A membered or 6-membered non-aromatic heterocyclic group or a substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group. More preferably, a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted acyloxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted 5-membered or 6-membered non-substituted An aromatic heterocyclic group or a substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group, provided that the aromatic heterocyclic group is a cyclic group substituted with at least two adjacent hydroxy groups Excluding cases).

R ^10b is substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, or substituted or unsubstituted lower alkoxy. Preferably, it is substituted or unsubstituted lower alkyl. More preferred is lower alkyl which is unsubstituted or substituted with halogen, amino, carbamoyl, acyloxy or carbamoyloxy.
Preferred substituents of “substituted or unsubstituted lower alkyl”, “substituted or unsubstituted lower alkenyl”, “substituted or unsubstituted lower alkynyl”, and “substituted or unsubstituted lower alkoxy” include amino, halogen, carboxy, carbamoyl Substituted or unsubstituted acyloxy, 5- or 6-membered non-aromatic heterocyclic carbonyl, 5- or 6-membered aromatic heterocyclic carbonyl, and the like.
Preferable substituents of “substituted or unsubstituted acyloxy” include halogen, lower alkyl, halo lower alkyl, lower cycloalkyl and the like. Preferred substituents of “substituted or unsubstituted carbamoyloxy” include lower alkyl and halo lower alkyl. Preferred substituents of the “substituted or unsubstituted non-aromatic heterocyclic group” include halogen, lower alkyl, halo-lower alkyl, oxo, hydroxy, lower alkoxy, cyano, nitro, amino and the like. The heterocyclic group is preferably a 5 or 6 membered group. More preferred examples of the non-aromatic heterocyclic group are dihydrotriazyl, dihydropyrimidyl, dihydropyridazyl, dihydrooxazolyl, dihydroimidazolyl, dihydrothiazolyl, pyrrolidyl, piperazyl, piperidyl or morpholinyl. . Preferred substituents of the “substituted or unsubstituted aromatic carbocyclic group” include halogen, lower alkyl, halo lower alkyl, hydroxy, lower alkoxy, cyano, nitro, amino and the like, and the aromatic carbocyclic Preferred examples of the group include phenyl, naphthyl, anthryl and the like. Preferred substituents of the “substituted or unsubstituted aromatic heterocyclic group” include halogen, lower alkyl, halo lower alkyl, oxo, hydroxy, lower alkoxy, cyano, nitro, amino and the like. The cyclic group is preferably a 5- or 6-membered group. More preferred examples of the aromatic heterocyclic group include pyrrolyl, quinolyl, phenyl, pyridyl, pyrimidyl, pyridazyl, pyrazolyl, triazolyl, oxazolyl, oxadiazolyl, imidazolyl, isothiazolyl, isoxadiazolyl, thiazolyl, thiadiazolyl, triazolyl or tetrazolyl It is. However, the case where at least two adjacent substituents are hydroxy is excluded.
More preferable examples of R ^10a include substituted or unsubstituted lower alkyl (eg, methyl, ethyl, isopropyl, aminomethyl, aminoethyl, acetoxymethyl, carbamoylmethyl, carbamoylethyl, piperazylcarbonylmethyl, morpholinylcarbonylmethyl). , Piperazylcarbonylethyl, morpholinylcarbonylethyl), substituted or unsubstituted acyloxy (eg acetoxy), substituted or unsubstituted carbamoyloxy (eg carbamoyloxy, dimethylcarbamoyloxy, monomethylcarbamoyloxy), or Group:

A group selected from:

More preferable examples of R ^10b include substituted or unsubstituted lower alkyl (eg, methyl, ethyl, isopropyl, aminomethyl, aminoethyl, acetoxymethyl, carbamoylmethyl, carbamoylethyl, piperazylcarbonylmethyl, morpholinylcarbonylmethyl). , Piperidylcarbonylmethyl, piperazylcarbonylethyl, morpholinylcarbonylethyl).

Preferred examples of formula (I) include formula (IC):

(Where
X is N, C (—H) or C (—Cl),
R ^2c is N or CH;
R ^9c is a hydrogen atom, hydroxy, lower alkoxy, halo lower alkyl or lower alkyl which is unsubstituted or substituted with carboxy or hydroxy,
U is —S— or —O—;
R ¹¹ is a carboxy cyclic bioisostere;
L is —S— or —CH ₂ —S—,
R ^10c is a substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group or a substituted or unsubstituted 5- or 6-membered non-aromatic heterocyclic group, and the substituent is preferably , Halogen, lower alkyl, halo-lower alkyl, oxo, hydroxy, lower alkoxy, cyano, nitro or amino).

Moreover, as a preferable example of Formula (I), Formula (ID):

Wherein X, R ^2c , R ^9c and R ¹¹ are as defined above,
U is —S— or —O—;
E ′ is a single bond or pyridinium in which a ring-ring cationic nitrogen atom is bonded to R ^10D ;
R ^10D is a hydrogen atom, a substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group, or a substituted or unsubstituted 5- or 6-membered non-aromatic heterocyclic group, where the substituent is Preferably, halogen, lower alkyl, halo lower alkyl, oxo, hydroxy, lower alkoxy, cyano, nitro or amino is exemplified. However, the case where at least two adjacent substituents are hydroxy is excluded. ).

Further, as a preferred example of the formula (I), the formula (IE):

Wherein X, R ^2c , R ^9c , R ¹¹ , Y ¹ , Y ² and n are as defined above,
U is —S— or —O—;
R ^10E is a hydrogen atom, lower alkyl, phenyl, substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group or substituted or unsubstituted 5- or 6-membered non-aromatic heterocyclic group, Examples of the substituent include halogen, lower alkyl, halo lower alkyl, oxo, hydroxy, lower alkoxy, cyano, nitro or amino. However, the case where at least two adjacent substituents are hydroxy is excluded. ).

Further, as a preferred example of the formula (I), the formula (IF):

(Wherein, X, R ^2c , R ^9c and R ¹¹ are as defined above,
U is —S— or —O—;
L is a single bond or —CH ₂ —;
R ^10F is a hydrogen atom, substituted or unsubstituted alkoxy, substituted or unsubstituted carbamoyloxy or substituted or unsubstituted acyloxy, wherein the substituent is preferably lower alkyl or halo-lower alkyl) Can be mentioned.

The naming of substitution positions on the Cephem skeleton of formula (I) is as follows. In this specification, the 3-position side chain, the 4-position side chain, and the 7-position side chain represent groups bonded to the 3-position, 4-position, and 7-position of the following cephem skeleton.

The compound (I) of the present invention is not limited to a specific isomer, but all possible isomers (for example, keto-enol isomer, imine-enamine isomer, diastereoisomer, optical isomer, rotational isomer, Isomers, stereoisomers, etc.), racemates or mixtures thereof.

For example, in formula (I)

Is

Is included.

In the compound (I) of the present invention, when R20 has the formula (Ib), that is, has E having a quaternary ammonium ion, the 4-position carboxy bioisostere forms an anion to form a zwitterion in the molecule. It may be. That is, in the compound represented by the formula (I), for example, when the substituent at the 4-position is a tetrazolyl group, the tetrazolyl group formed an anion.

The structure shown by is included. The same applies to other carboxy bioisosteres.

Furthermore, the compound represented by the formula (I) has a carboxy bioisostere, for example,

And a resonance structure such as The same applies when a carboxy bioisostere forms an anion, for example,

Including resonance structures.

One or more hydrogen, carbon and / or other atoms of the compound of formula (I) may be replaced with isotopes of hydrogen, carbon and / or other atoms, respectively. Examples of such isotopes are ² H, ³ H, ¹¹ C, ¹³ C, ¹⁴ C, ¹⁵ N, ¹⁸ O, ¹⁷ O, ³¹ P, ³² P, ³⁵ S, ¹⁸ F, ¹²³ I and ^{Like 36} Cl, hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, iodine and chlorine are included. The compound represented by the formula (I) also includes a compound substituted with such an isotope. The compound substituted with the isotope is also useful as a pharmaceutical, and includes all radiolabeled compounds of the compound represented by the formula (I). A “radiolabeling method” for producing the “radiolabeled product” is also encompassed in the present invention, and is useful as a metabolic pharmacokinetic study, a study in a binding assay, and / or a diagnostic tool.

The radioactive label of the compound represented by the formula (I) can be prepared by a method well known in the art. For example, the tritium-labeled compound represented by the formula (I) can be prepared by introducing tritium into the specific compound represented by the formula (I) by, for example, catalytic dehalogenation reaction using tritium. This method reacts a tritium gas with a precursor in which the compound of formula (I) is appropriately halogen-substituted in the presence of a suitable catalyst such as Pd / C, in the presence or absence of a base. Including that. Suitable methods for preparing other tritium labeled compounds include the document Isotopes in the Physical and Biomedical Sciences, Vol. 1, Labeled Compounds (Part A), Chapter 6 (1987). ¹⁴ C-labeled compounds can be prepared by using raw materials having ¹⁴ C carbon.

The salt of the compound represented by the formula (I) is a salt in which the carboxyl group at the 7-position and / or the amino group at the 7-position forms a salt with an inorganic base, an organic base, an inorganic acid or an organic acid, and This includes cases where the 3rd-position side chain quaternary amine moiety forms an internal salt with an anion on the 4th-position bioisostere or a salt formed with other counter anions.

As the pharmaceutically acceptable salt of the compound represented by the formula (I), for example, a compound represented by the formula (I), an alkali metal (for example, lithium, sodium, potassium, etc.), an alkaline earth metal (for example, Calcium, barium, etc.), magnesium, transition metals (eg, zinc, iron, etc.), ammonia, organic bases (eg, trimethylamine, triethylamine, dicyclohexylamine, ethanolamine, diethanolamine, triethanolamine, meglumine, diethanolamine, ethylenediamine, pyridine, Picolin, quinoline etc.) and salts with amino acids, or inorganic acids (eg hydrochloric acid, sulfuric acid, nitric acid, carbonic acid, hydrobromic acid, phosphoric acid, hydroiodic acid etc.) and organic acids (eg formic acid, acetic acid, Propionic acid, trifluoroacetic acid, citric acid, lactic acid Tartaric acid, oxalic acid, maleic acid, fumaric acid, mandelic acid, glutaric acid, malic acid, benzoic acid, phthalic acid, ascorbic acid, benzenesulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, etc.) Salt. Particularly, salts with hydrochloric acid, sulfuric acid, phosphoric acid, tartaric acid, methanesulfonic acid and the like can be mentioned. These salts can be formed by a commonly performed method.

The compound represented by the formula (I) or a pharmaceutically acceptable salt thereof may form a solvate (for example, hydrate etc.) and / or a crystalline polymorph. Also included are solvates and crystalline polymorphs. The “solvate” may be coordinated with an arbitrary number of solvent molecules (for example, water molecules) with respect to the compound represented by the formula (I). When the compound represented by the formula (I) or a pharmaceutically acceptable salt thereof is left in the air, it may absorb moisture and adsorbed water may adhere or form a hydrate. In some cases, the compound represented by formula (I) or a pharmaceutically acceptable salt thereof may be recrystallized to form a crystalline polymorph thereof.

The compound represented by the formula (I) or a pharmaceutically acceptable salt thereof may form a prodrug, and the present invention includes such various prodrugs. A prodrug is a derivative of a compound of the present invention having a group that can be chemically or metabolically degraded, and is a compound that becomes a pharmaceutically active compound of the present invention by solvolysis or under physiological conditions in vivo. A prodrug is a compound that is enzymatically oxidized, reduced, hydrolyzed, etc. under physiological conditions in vivo to be converted to a compound represented by formula (I), hydrolyzed by gastric acid, etc. The compound etc. which are converted into the compound shown are included. Methods for selecting and producing suitable prodrug derivatives are described, for example, in Design of Prodrugs, Elsevier, Amsterdam 1985. Prodrugs may themselves have activity.

When the compound represented by formula (I) or a pharmaceutically acceptable salt thereof has a hydroxyl group, for example, a compound having a hydroxyl group and a suitable acyl halide, a suitable acid anhydride, a suitable sulfonyl chloride, a suitable sulfonyl Examples thereof include prodrugs such as carbonyloxy derivatives and sulfonyloxy derivatives produced by reacting anhydride and mixed anhydride or reacting with a condensing agent. For example, CH ₃ COO—, C ₂ H ₅ COO—, t-BuCOO—, C ₁₅ H ₃₁ COO—, PhCOO—, (m-NaOOCPh) COO—, NaOOCCH ₂ CH ₂ COO—, CH ₃ CH (NH ₂ ) COO—, CH ₂ N (CH ₃ ) ₂ COO—, CH ₃ SO ₃ —, CH ₃ CH ₂ SO ₃ —, CF ₃ SO ₃ —, CH ₂ FSO ₃ —, CF ₃ CH ₂ SO ₃ —, p— CH ₃ —O—PhSO ₃ —, PhSO ₃ —, and p-CH ₃ PhSO ₃ — can be mentioned.

In the synthesis of the compound represented by the formula (I), the compounds (VIII), (X), (XX) and the following formula:

(Wherein Y is a leaving group, U, R ³ and R ¹¹ are as defined above, and P is an amino protecting group or a hydroxy protecting group described later)
A compound represented by (or a salt thereof) is preferable as an intermediate.
Examples of the leaving group include halogen (Cl, Br, I, F), methanesulfonyloxy, p-toluenesulfonyloxy, trifluoromethanesulfonyloxy and the like.

As described in the following general synthesis methods and examples, the compound of the present invention represented by the formula (I) has side chain sites bonded to the 3-position, 4-position and 7-position of the above-mentioned intermediate cephem skeleton, respectively. Can be obtained. Examples of the protecting group P include protecting groups described in the following general synthesis. Preferred examples include benzhydryl, paramethoxybenzyl, trityl, 2,6-dimethoxybenzyl, methoxymethyl, benzyloxymethyl, and allyl. Examples thereof include oxycarbonyl and 2- (trimethylsilyl) ethoxymethyl.

(General synthesis method)
The compound represented by the formula (I) according to the present invention can be produced, for example, by the general synthesis method shown below.

In the formula, W, U, R ¹ , R ^2A , R ^2B , R ³ , R ²⁰ , G, L and R ¹¹ are as defined above, L ′ is a single bond, —CH ₂ —, —CH═ CH—, L ″ represents a hydrogen atom, —SH, —CH ₂ —SH or —CHO, P represents a protecting group, Y represents a leaving group (eg, halogen (Cl, Br, I, F)) Methanesulfonyloxy, p-toluenesulfonyloxy, trifluoromethanesulfonyloxy, triphenylphosphonium, etc.).

1) 7-position side chain formation: Synthesis step 1 of compound (X)
Compound (X) is obtained by subjecting compound (VIII) obtained according to the method described in the literature (example: WO2012 / 147773, WO2013 / 2215) to a condensation reaction with compound (IX). Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, ethyl acetate, n-butyl acetate), halogenated carbonization Hydrogens (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg, acetone, methyl ethyl ketone), nitriles (eg, MeCN, propionitrile), nitros (eg, nitromethane, nitroethane, nitrobenzene), dimethyl sulfoxide, water and the like are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 20 ° C., more preferably about −60 to −20 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

2) 3-position side chain formation: Synthesis step 2 of compound (I)
Compound (I) is obtained by reacting compound (X) with compound (XI) and then subjecting it to a deprotection reaction by a method well known to those skilled in the art. Examples of the solvent for the reaction of compound (X) and compound (XI) include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, Ethyl acetate, n-butyl acetate), halogenated hydrocarbons (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg acetone, methyl ethyl ketone), nitriles (eg MeCN, propionitrile), nitros (eg nitromethane, nitroethane, nitrobenzene) ), Dimethyl sulfoxide, water, etc. It is exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −40 to 0 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

The compound represented by the formula (I) can also be produced by the synthesis method shown below.

In the formula, W, R ¹ , R ^2A , R ^2B , R ³ , R ²⁰ , G, L and R ¹¹ are as defined above, U represents S, L ′ represents a single bond, —CH ₂ — , —CH═CH—, L ″ represents a hydrogen atom, —SH, —CH ₂ —SH or —CHO, P represents a protecting group, Y represents a leaving group (eg, halogen (Cl, Br, I, F), methanesulfonyloxy, p-toluenesulfonyloxy, trifluoromethanesulfonyloxy, triphenylphosphonium and the like.

1) 7-position side chain formation: Compound (XIX) synthesis step 1
Compound (XIX) is obtained by subjecting compound (XVIII) obtained according to the method described in the literature (example: WO2012 / 147773, WO2013 / 2215) to a condensation reaction with compound (IX). Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, ethyl acetate, n-butyl acetate), halogenated carbonization Hydrogens (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg, acetone, methyl ethyl ketone), nitriles (eg, MeCN, propionitrile), nitros (eg, nitromethane, nitroethane, nitrobenzene), dimethyl sulfoxide, water and the like are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −60 to 0 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Process 2
Compound (XIX) is subjected to an oxidation reaction with an oxidant well known to those skilled in the art (eg, m-chloroperbenzoic acid) to give compound (XX). Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, ethyl acetate, n-butyl acetate), halogenated carbonization Hydrogens (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg, acetone, methyl ethyl ketone), nitriles (eg, MeCN, propionitrile), nitros (eg, nitromethane, nitroethane, nitrobenzene), dimethyl sulfoxide, water and the like are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −60 to −30 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

2) 3-position side chain formation: Synthesis step 3 of compound (I)
Compound (XX) is reacted with compound (XI) by a method well-known to those skilled in the art, then reduced with a reducing agent well-known to those skilled in the art (eg, phosphorus tribromide), and then subjected to a deprotection reaction. Obtain (I). Examples of the solvent for the reaction of compound (XX) and compound (XI) include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, Ethyl acetate, n-butyl acetate), halogenated hydrocarbons (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg acetone, methyl ethyl ketone), nitriles (eg MeCN, propionitrile), nitros (eg nitromethane, nitroethane, nitrobenzene) ), Dimethyl sulfoxide, water There are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −40 to 0 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Compound (XX) can also be obtained by reducing compound (XX) with a reducing agent well known to those skilled in the art (for example, phosphorus tribromide), reacting with compound (XI), and then subjecting to deprotection reaction. .

Further, when L contains a sulfide group (—S—), the compound represented by the formula (I) can also be produced by the synthesis method of Scheme 3 below.

In the formula, W, R ¹ , R ^2A , R ^2B , R ³ , R ^10b , R ¹¹ and E are as defined above, U represents S, and L ′ represents a single bond or —CH ₂ —. , L represents —S— or —CH 2 —S—, P represents a protecting group, Y represents a leaving group (eg, halogen (Cl, Br, I, F), methanesulfonyloxy, p-toluenesulfonyloxy) , Trifluoromethanesulfonyloxy and the like.

Process 1
Compound (I) is obtained by reacting compound (X) with compound (II). Examples of the solvent for the reaction of compound (X) with compound (II) include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, Ethyl acetate, n-butyl acetate), halogenated hydrocarbons (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg acetone, methyl ethyl ketone), nitriles (eg MeCN, propionitrile), nitros (eg nitromethane, nitroethane, nitrobenzene) ), Dimethyl sulfoxide, water, etc. It is exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −40 to 0 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Furthermore, when the compound represented by the formula (I) has a tetrazole ring at the 4-position and L contains a double bond, the compound represented by the formula (I) can also be produced by the synthesis method of the following scheme 4.

Wherein R ¹ , R ^2A , R ^2B , R ³ , R ^10a , Y ¹ , Y ² , n, U and W are as defined above, and R ¹³ is a substituted or unsubstituted aromatic carbocyclic group. represents a group, X ^- represents a counter anion, ^{P 1} and ^{P 2} represents a protecting group.

Process 1
Compound (IV) obtained by subjecting compound (III) obtained according to the method described in the literature (eg, WO2012 / 147773, WO2013 / 2215) to an oxidation reaction with an oxidant well known to those skilled in the art (eg, Jones reagent) is obtained. Get. Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, ethyl acetate, n-butyl acetate), halogenated carbonization Hydrogens (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg, acetone, methyl ethyl ketone), nitriles (eg, MeCN, propionitrile), nitros (eg, nitromethane, nitroethane, nitrobenzene), dimethyl sulfoxide, water and the like are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −60 to −30 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Process 2
Compound (IV) and compound (V) obtained according to the method described in the literature (eg, WO2002 / 1433) are subjected to a well-known Witting reaction as described in Example 1 and then known to those skilled in the art. By subjecting to deprotection, compound (VI) is obtained. Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether) hydrocarbons (eg, n-hexane, benzene, toluene) and the like. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to room temperature, preferably about −80 to room temperature. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Compound (Ia) is obtained by subjecting compound (VI) and compound (IX) to the same condensation reaction as in Step 1 of Scheme 1 followed by deprotection reaction well known to those skilled in the art. Examples of the reaction solvent include ethers (eg, anisole, dioxane, tetrahydrofuran, diethyl ether, tert-butyl methyl ether, diisopropyl ether), esters (eg, ethyl formate, ethyl acetate, n-butyl acetate), halogenated carbonization Hydrogens (eg, dichloromethane, chloroform, carbon tetrachloride), hydrocarbons (eg, n-hexane, benzene, toluene), amides (eg, formamide, N, N-dimethylformamide, N, N-dimethylacetamide, N-methylpyrrolidone), ketones (eg, acetone, methyl ethyl ketone), nitriles (eg, MeCN, propionitrile), nitros (eg, nitromethane, nitroethane, nitrobenzene), dimethyl sulfoxide, water and the like are exemplified. These solvents may be used alone or in combination of two or more. The reaction temperature is usually about −100 to 100 ° C., preferably about −80 to 50 ° C., more preferably about −60 to 0 ° C. The reaction time varies depending on the reagent, solvent and reaction temperature used, but is usually 0.5 to 24 hours.

Protecting groups (amino protecting group, hydroxyl protecting group, etc.) that can be used in the above reaction include, for example, Protective Groups in Organic Synthesis, T. et al. W. By Greene, John Wiley & Sons Inc. (1991) and the like. Methods for introducing and removing protecting groups are described in methods commonly used in organic synthetic chemistry (for example, see Protective Groups in Organic Synthesis, TW Greene, John Wiley & Sons Inc. (1991)). It can obtain according to the method or them. In addition to the above production method, the functional group contained in each substituent can be converted by a known method (for example, Comprehensive Organic Transformations, RC Larock (1989)). Some of the compounds of the invention can lead to further novel derivatives as synthetic intermediates. The intermediates and target compounds in each of the above production methods can be isolated and purified by purification methods commonly used in synthetic organic chemistry, such as neutralization, filtration, extraction, washing, drying, concentration, and various chromatography. it can. In addition, the intermediate can be subjected to the next reaction without any particular purification.

For example, amino protecting groups include phthalimide, lower alkoxycarbonyl (butoxycarbonyl (Boc), etc.), lower alkenyloxycarbonyl (allyloxycarbonyl (Alloc), etc.), benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, (substituted) Examples include aralkanoyl (p-nitrobenzoyl etc.), acyl (formyl, chloroacetyl etc.), (substituted) aralkyl (trityl etc.), benzhydryl (Bzh) and the like.

For example, hydroxyl protecting groups include, for example, lower alkoxycarbonyl such as C ₁ -C ₄ alkoxycarbonyl (eg t-butyloxycarbonyl), halogenated (C ₁ -C ₃ ) alkoxycarbonyl (eg 2-iodoethyl Halogenated lower alkoxycarbonyl such as oxycarbonyl, 2,2,2-trichloroethyloxycarbonyl), phenyl (C ₁ -C ₄ ) alkoxycarbonyl (benzyloxycarbonyl, o Aryl (lower) alkoxycarbonyl such as -nitrobenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, p-methoxybenzyloxycarbonyl), p-methoxybenzyl (PMB), tri (C ₁ -C ₄ ) alkylsilyl (for example, Trimethi Silyl, tri (lower) alkylsilyl such as t- butyldimethylsilyl), C ₁ -C ₄ alkoxymethyl (e.g., methoxymethyl), C ₁ -C ₄ alkoxy (C ₁ -C ₄₎ alkoxymethyl (e.g., 2 -Methoxyethoxymethyl), substituted methyl such as C ₁ -C ₄ alkylthiomethyl (eg methylthiomethyl), tetrahydropyranyl, and the like.

The deprotection reactions described above are tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile or their In a solvent such as a mixed solvent, Lewis acid (eg, AlCl ₃ , SnCl ₄ , TiCl ₄ ), protonic acid (eg, HCl, HBr, H ₂ SO ₄ , HCOOH) or the like may be used.

The obtained compound (I) can be further chemically modified to synthesize an ester form, a protected form of amino on the thiazole ring at the 7-position, or a pharmaceutically acceptable salt or solvate thereof.

The compound of the present invention has a broad spectrum of antibacterial activity, and various diseases caused by pathogenic bacteria in various mammals including humans such as respiratory tract infections, urinary tract infections, respiratory infections, sepsis, nephritis, gallbladder It can be used for the prevention or treatment of inflammation, oral infection, endocarditis, pneumonia, osteomyelitis, otitis media, enteritis, empyema, wound infection, opportunistic infection and the like.

The compound of the present invention is colonized in Gram-negative bacteria, preferably in the Enterobacteriaceae family, including CRE (E. coli, Klebsiella, Serratia, Enterobacter, Citrobacter, Morganella, Providencia, Proteus, etc.), respiratory organs High antibacterial activity against Gram-negative bacteria (Hemophilus, Moraxella, etc.) and non-glucose gram-negative bacteria (Pseudomonas, Pseudomonas other than Pseudomonas aeruginosa, Stenotrophomonas, Burkholderia, Acinetobacter, etc.). It is stable to β-lactamases belonging to classes A, B, C and D produced by these gram-negative bacteria. In particular, it is extremely stable against ESBL-producing bacteria belonging to class A including TEM, SHV, CTX-M, KPC, etc. Even it is effective. The compound of the present invention also has antibacterial activity against gram-positive bacteria including penicillin resistant staphylococcus pneumoniae (PRSP) and the like. Further preferable compounds have characteristics such as high blood concentration, long duration of effect, and / or remarkable tissue transferability as pharmacokinetics. Preferred compounds are safe in terms of side effects such as no fever and no nephrotoxicity. Further, preferred compounds have high water solubility and are particularly suitable as injections.

The compound of the present invention can be administered orally or parenterally. In the case of oral administration, the compound of the present invention is any of ordinary preparations, for example, solid preparations such as tablets, powders, granules, capsules; liquid preparations; oil suspensions; or liquid preparations such as syrups or elixirs. It can also be used as a dosage form. In the case of parenteral administration, the compound of the present invention can be used as an aqueous or oily suspension injection or nasal solution. In the preparation, conventional excipients, binders, lubricants, aqueous solvents, oily solvents, emulsifiers, suspending agents, preservatives, stabilizers and the like can be arbitrarily used. The formulations of the present invention are prepared by combining (eg, mixing) a therapeutically effective amount of a compound of the present invention with a pharmaceutically acceptable carrier or diluent.

The compound of the present invention can be administered parenterally or orally as an injection, capsule, tablet, or granule, but is preferably administered as an injection. The dose is usually about 0.1 to 100 mg / day, preferably about 0.5 to 50 mg / day per kg of the body weight of the patient or animal. Good. When used as an injection, the carrier is, for example, distilled water, physiological saline or the like, and a base for adjusting pH may be used. Carriers when used as capsules, granules, tablets are known excipients (eg, starch, lactose, sucrose, calcium carbonate, calcium phosphate, etc.), binders (eg, starch, gum arabic, carboxymethyl cellulose) , Hydroxypropyl cellulose, crystalline cellulose, etc.), lubricants (eg, magnesium stearate, talc, etc.).

Hereinafter, the present invention will be described in more detail with reference to Examples, Reference Examples, Test Examples, and Preparation Examples, but the present invention is not limited thereto.

The meaning of each abbreviation is as follows.
Ac: acetyl Alloc: allyloxycarbonyl Boc: tert-butoxycarbonyl BH: benzhydryl Bzh: benzhydryl DMF: N, N-dimethylformamide EDC: 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide i-Pr: isopropyl mCPBA : M-chloroperbenzoic acid Me: methyl ODS: octadecylsilyl PMB: paramethoxybenzyl t-Bu: tert-butyl TFA: trifluoroacetic acid WSCD: N-ethyl-N '-(3-dimethylaminopropyl) carbodiimide

The NMR analysis obtained in each example was performed at 400 MHz and measured using d ₆ -DMSO and CDCl ₃ .

(Example 1)
Synthesis of Compound I-1 (Cetofibrol 4-position tetrazole)

Step 1 Synthesis of Compound 1b
Compound 1a (4.75 g, 10 mmol) was suspended in tetrahydrofuran (50 mL), and 2,6-lutidine (2.91 ml, 25 mmol) and allyl chloroformate (1.28 mL, 12 mmol) were successively added under ice cooling. . The reaction mixture was stirred for 30 minutes under ice-cooling, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure.
The obtained residue was dissolved in tetrahydrofuran (150 mL) and water (50 mL), and the mixture was stirred at 50 ° C. for 5 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and then saturated brine and dried over anhydrous magnesium sulfate. Yield 99%).
¹ H-NMR (CDCl ₃ ) δ: 4.08 (brs, 1H), 4.61 (m, 2H), 5.23-5.36 (m, 4H), 5.49 (brd, J = 9.6Hz, 1H), 5.70 (rbd, J = 9.3Hz, 1H), 5.85-5.96 (m, 2H), 6.34 (s, 1H), 7.24-7.38 (m, 10H).

Step 2 Synthesis of Compound 1c
Compound 1b (4.96 g, 9.83 mmol) was dissolved in acetone (50 mL), and Jones reagent (5.51 ml, 14.8 mmol) was added under ice cooling. The reaction mixture was stirred for 30 minutes under ice-cooling, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure.
The resulting residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain Compound 1c (2.95 g, yield 60%).
¹ H-NMR (CDCl ₃ ) δ: 4.61 (m, 2H), 5.22-5.35 (m, 4H), 5.41 (dd, J = 3.6, 8.4Hz, 1H), 5.70 (d, J = 8.7Hz, 1H ), 5.90 (m, 1H), 6.25 (s, 1H), 7.21-7.40 (m, 10H), 7.62 (s, 1H), 9.27 (s, 1H).

Step 3 Synthesis of Compound 1e
Compound 1c (2.94 g, 5 mmol) and compound 1d (2.98 g, 5 mmol) known in WO2002014433 are dissolved in methylene chloride (35 mL), 1,2-epoxybutane (35 mL) is added, and 8 The mixture was refluxed for an hour. The solvent was distilled off from the reaction solution under reduced pressure, and the resulting residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain Compound 1e (4.44 g, yield 82%).
¹ H-NMR (CDCl ₃ ) δ: 1.46 (9H, s), 1.94-2.07 (2H, m), 2.81-2.84 (2H, m), 3.19-3.59 (6H, m), 4.60 (2H, d, J = 5.6 Hz), 4.78-4.80 (1H, m), 5.19-5.35 (3H, m), 5.45 (1H, dd, J = 9.5, 3.4 Hz), 5.72 (1H, d, J = 9.5 Hz), 5.84-5.95 (1H, m), 6.04 (1H, s), 6.61 (1H, s), 6.75 (1H, s), 7.20-7.69 (10H, m).

Step 4 Synthesis of Compound 1f
Compound 1e (4.36 g, 5.85 mmol) was dissolved in methylene chloride (40 mL), cooled to −40 ° C., and 65% -m-chloroperbenzoic acid (1.38 g, 5.19 mmol) was added. . The reaction mixture was stirred for 20 minutes under ice cooling, and then an aqueous solution of sodium thiosulfate (0.75 g, 4.72 mmol) was added. Subsequently, ethyl acetate was added and concentrated under reduced pressure, and then the organic layer was separated. The organic layer was washed twice with aqueous sodium hydrogen carbonate solution and then with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was subjected to silica gel column chromatography, eluting with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain Compound 1f (1.25 g, yield 35%).
¹ H-NMR (CDCl ₃ ) δ: 1.46 (9H, s), 1.95-2.09 (2H, m), 2.58 (1H, m), 3.01-3.07 (1H, m), 3.20-3.57 (7H, m) , 4.24 (1H, d, J = 17.7 Hz), 4.62 (2H, d, J = 5.4 Hz), 4.72 (1H, d, J = 4.8 Hz), 4.80 (1H, m), 5.23-5.37 (2H, m), 5.83-5.98 (2H, m), 6.11 (1H, d, J = 10.8 Hz), 7.22-7.41 (12H, m).

Step 5 Synthesis of Compound 1g
Compound If (1.24 g, 1.64 mmol) was dissolved in dimethylformamide (15 mL), cooled to −40 ° C., and phosphorus tribromide (0.47 mL, 4.93 mmol) was added. The reaction mixture was stirred at −40 ° C. for 30 minutes, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed twice with water and then distilled off under reduced pressure to obtain 1 g (1.24 g, yield 102%) of a compound.
¹ H-NMR (CDCl ₃ ) δ: 1.46 (9H, s), 1.95-2.45 (4H, m), 2.89-3.01 (1H, m), 3.20-3.57 (5H, m), 3.70 (2H, s) , 4.61, 4.65 (2H, ABq, J = 18.8 Hz), 4.82-4.91 (1H, m), 5.14 (1H, d, J = 5.1 Hz), 5.25 (1H, d, J = 10.5 Hz), 5.34 ( 1H, d, J = 17.1 Hz), 5.66 (1H, dd, J = 5.1, 9.6 Hz), 5.87-6.00 (1H, m), 6.08 (1H, d, J = 9.6 Hz), 7.27-7.48 (12H , m)

Step 6 Synthesis of Compound 1h
Compound 1g (1.22 g, 1.62 mmol) was dissolved in methylene chloride (15 mL), dimedone (679 mg, 4.84 mmol) and tetrakis (triphenylphosphine) palladium (93 mg, 0.08 mmol) were sequentially added to the refrigerator. The mixture was allowed to stand overnight and then stirred at room temperature for 3.5 hours. An aqueous sodium hydrogen carbonate solution was added to the reaction solution, and the methylene chloride layer was separated. The methylene chloride layer was dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 1h (0.87 g, yield 82%).
¹ H-NMR (CDCl ₃ ) δ: 1.40 (9H, s), 2.02 (1H, brs), 2.23-2.40 (3H, m), 2.66-2.82 (1H, m), 3.01-3.40 (5H, m) , 3.89, 4.01 (2H, ABq, J = 23.2 Hz), 4.49-4.63 (1H, m), 4.87 (1H, brs), 5.19 (1H, d, J = 5.1 Hz), 6.99 (1H, s), 7.28-7.45 (10H, m), 7.82 (1H, s).

Step 7 Synthesis of Compound 1j
Compound 1i (0.59 g, 1.45 mmol) was dissolved in N, N-dimethylacetamide (10 mL), and triethylamine (237 μL, 1.71 mmol) was added. Next, the reaction solution was cooled to −20 ° C., methanesulfonyl chloride (123 μL, 1.58 mmol) was added, and the mixture was stirred at −20 ° C. for 20 minutes to obtain a mixed acid anhydride of compound 1i and methanesulfonic acid. Prepared.
On the other hand, Compound 1h (0.59 g, 1.45 mmol) was dissolved in N, N-dimethylacetamide (10 mL), and N-methylmorpholine (289 μL, 2.63 mmol) was added. The mixed acid anhydride solution prepared above was added to this solution under ice cooling. The reaction solution was stirred for 10 minutes under ice cooling, water was added, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give compound 1j (1.57 g, yield 114%).
¹ H-NMR (CDCl ₃ ) δ: 1.50-1.57 (18H, m), 2.02 (1H, brs), 1.94-2.15 (2H, m), 2.35-2.80 (2H, m), 3.20-3.60 (4H, m), 3.72-3.77 (4H, m), 4.79 (1H, brm), 5.23-5.30 (2H, m), 5.30, 5.47 (2H, ABq, J = 15.8Hz), 6.10 (1H, dd, J = 4.8, 8.8 Hz), 6.79-6.86 (3H, m), 7.21-7.41 (13H, m).

Step 8 Synthesis of Compound I-1
Compound 1j (1.56 g, 1.49 mmol) was dissolved in methylene chloride (20 mL) and anisole (1.71 mL, 15.7 mmol) was added. The reaction mixture was then cooled to −20 ° C., 2 mol / L-aluminum chloride / nitroethane solution (7.83 mL, 15.7 mmol) was added, and the mixture was stirred at −20 ° C. for 80 minutes. Dilute hydrochloric acid, acetonitrile, and isopropyl ether were added to the reaction solution, and the aqueous layer was separated. HP-20SS was added to the aqueous layer, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to obtain Compound I-1 (0.14 g, yield 19%).
¹ H-NMR (DMSO-D ₆ ) δ: 2.01-2.23 (2H, m), 2.89-3.01 (1H, m), 3.14-3.37 (7H, m), 3.89, 3.98 (2H, ABq, J = 23.0 Hz), 4.51-4.61 (1H, m), 5.32 (1H, d, J = 5.0 Hz), 5.83 (1H, dd, J = 8.4, 5.0 Hz), 7.24 (1H, s), 8.08 (2H, s ), 8.89 (2H, br s), 9.48 (1H, d, J = 10.0 Hz).

(Example 2)
Synthesis of Compound I-2 (Cefcapene 4-position tetrazole)

Step 1: Synthesis of Compound 2b
Compound 2b was obtained in the same manner as in Step 7 of Example 1 using Compound 2a (7.39 g, 23.76 mmol) and Compound 1a (9.41 g, 19.8 mmol). The crude product was then subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 2b (5.08 g, yield 36%).
¹ H-NMR (CDCl ₃ ) δ: 1.10 (3H, t, J = 7.5 Hz), 1.54 (9H, s), 2.47 (2H, td, J = 7.5, 3.3 Hz), 4.03-4.10 (2H, m ), 5.37 (1H, d, J = 4.0 Hz), 5.67 (1H, dd, J = 7.5, 3.9 Hz), 6.00 (1H, s), 6.40-6.50 (3H, m), 6.75 (1H, s) , 7.23-7.41 (10H, m), 7.84 (1H, d, J = 7.6 Hz), 8.49 (1H, s).

Step 2: Synthesis of Compound 2c
Compound 2b (2.42 g, 3.36 mmol) was dissolved in tetrahydrofuran (75 mL) and water (25 mL), and the mixture was stirred at 40 ° C. for 15 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine in that order, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resulting residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain compound 2c (1.55 g, yield 66%).
¹ H-NMR (CDCl ₃ ) δ: 1.10 (3H, t, J = 7.2 Hz), 1.53 (9H, s), 2.49 (2H, m), 4.06 (2H, brs), 5.32 (1H, d, J = 3.6 Hz), 5.63 (1H, dd, J = 7.8, 3.9 Hz), 5.89 (1H, d, J = 1.5 Hz), 6.30 (1H, d, J = 1.8 Hz), 6.44 (1H, t, J = 7.5 Hz), 6.78 (1H, s), 7.23-7.43 (10H, m), 7.84 (1H, d, J = 7.8 Hz), 8.88 (1H, brs).

Step 3: Synthesis of Compound 2d Compound 2c (1.52 g, 2.82 mmol) was dissolved in tetrahydrofuran (25 mL), and chlorosulfonyl osocyanate (0.245 mL, 2.82 mmol) was added at −40 ° C. The reaction solution was stirred at −30 ° C. for 10 minutes, and then sodium hydrogen carbonate (0.911 g, 10.84 mmol) and then water (0.5 mL) were added. Subsequently, after stirring for 50 minutes at room temperature, water was added and extracted with ethyl acetate. The ethyl acetate layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give compound 2d (1.55 g, yield 66%).
¹ H-NMR (CDCl ₃ ) δ: 1.09 (3H, t, J = 7.5 Hz), 1.54 (10H, s), 2.43-2.52 (2H, m), 4.42, 4.56 (2H, ABq, J = 17.2 Hz ), 4.62 (2H, bs), 5.34 (1H, d, J = 3.8 Hz), 5.66 (1H, dd, J = 7.9, 3.7 Hz), 5.86 (1H, s), 6.43 (1H, t, J = 7.8Hz), 6.47 (2H, s), 6.75 (1H, s), 7.25-7.38 (10H, m), 7.94 (1H, s), 8.82 (1H, s).

Step 4: Synthesis of Compound 2e
Compound 2d (1.48 g, 1.99 mmol) was dissolved in methylene chloride (20 mL), and a solution of 65% -m-chloroperbenzoic acid (343 mg, 1.99 mmol) in methylene chloride (5 mL) at −50 ° C. added. The reaction mixture was stirred at −50 ° C. for 20 minutes, an aqueous solution of sodium thiosulfate (315 mg, 1.99 mmol) was added, and the methylene chloride layer was separated. The methylene chloride layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.
The obtained residue (1.31 g, 1.72 mmol as S-oxide) was dissolved in dimethylformamide (10 mL), and phosphorus tribromide (0.325 mL, 3.45 mmol) was added at -78 ° C. Stir at −78 ° C. for 40 minutes. Next, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine in that order, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resulting residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain compound 2e (0.53 g, yield 36%).
¹ H-NMR (CDCl ₃ ) δ: 1.10 (3H, t, J = 7.5 Hz), 1.52 (9H, s), 2.46-2.56 (2H, m), 3.47, 3.61 (2H, ABq, J = 24.0 Hz ), 4.73 (2H, brs), 4.77, 4.96 (2H, ABq, J = 17.2 Hz), 5.16 (1H, d, J = 4.9 Hz), 5.95 (1H, dd, J = 8.5, 5.0 Hz), 6.41 (1H, t, J = 7.6 Hz), 6.74 (1H, s), 7.42-7.21 (10H, m), 7.79 (1H, d, J = 8.4 Hz), 8.63 (1H, s).

Step 5: Synthesis of Compound I-2
Compound 2e (0.51 g, 0.69 mmol) was dissolved in methylene chloride (10 mL) and anisole (749 μL, 6.86 mmol) was added. Next, the reaction solution was cooled to −30 ° C., and a 2 mol / L-aluminum chloride / nitromethane solution (3.43 mL, 6.86 mmol) was added, followed by stirring at −20 ° C. for 20 minutes and then with ice cooling for 30 minutes. did. Dilute hydrochloric acid, acetonitrile, and isopropyl ether were added to the reaction solution, and the aqueous layer was separated. HP-20SS was added to the aqueous layer, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile and 0.01 mol / L-acetonitrile were collected, and the pH was adjusted to 2.9 with 2 mol / L-NaOH aqueous solution. Next, the mixture was stirred for 2 hours under ice cooling, and the precipitated solid was collected by filtration to obtain Compound I-2 (151 mg, yield 46%).
¹ H-NMR (DMSO-D ₆ ) δ: 1.00 (3H, t, J = 7.4 Hz), 2.12-2.22 (2H, m), 3.64, 3.70, (2H, ABq, J = 24.0 Hz), 4.59, 4.82 (2H, ABq, J = 16.8 Hz), 5.41 (1H, d, J = 4.9 Hz), 5.79 (1H, dd, J = 7.9, 5.0 Hz), 6.21 (1H, s), 6.24 (1H, t , J = 7.8 Hz), 6.60 (2H, br s), 7.06 (2H, s), 9.33 (1H, d, J = 7.9 Hz).

(Example 3)
Synthesis of Compound I-3 (Cetriaxone 4-position tetrazole)

Step 1: Synthesis of Compound 3b
Compound 3a (687 mg, 0.951 mmol) was dissolved in tetrahydrofuran (10 mL), and sodium iodide (426 mg, 2.85 mmol) was added at 15 ° C., followed by stirring for 30 minutes. Next, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 3b (815 mg, yield 105%).
¹ H-NMR (CDCl ₃ ) δ: 1.52 (9H, s), 3.60, 3.88 (2H, ABq, J = 23.8 Hz), 4.08 (3H, s), 4.31, 4.46 (2H, ABq, J = 12.8 Hz ), 5.21 (1H, d, J = 5.1 Hz), 5.99 (1H, dd, J = 4.5, 8.7 Hz), 7.25-7.39 (12H, m), 8.45 (1H, brs).

Step 2 Synthesis of Compound 3d
Compound 3c (175 mg, 1.103 mmol) was dissolved in dimethylformamide (5 mL) and sodium carbonate (127 mg, 0.919 mmol) was added. To the reaction solution was added a solution of compound 3b (787 mg, 0.919 mmol) in dimethylformamide (5 ml) at −30 ° C., and the mixture was stirred for 1 hour. Next, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 3d (780 mg, yield 100%).
¹ H-NMR (CDCl ₃ ) δ: 1.51 (9H, s), 3.68 (3H, s), 3.67, 3.77 (2H, ABq, J = 26 Hz), 4.06 (3H, s), 4.13, 4.60 (2H , ABq, J = 18.0 Hz), 5.21 (1H, d, J = 4.8 Hz), 6.04 (1H, dd, J = 5.1, 9.0 Hz), 7.25-7.39 (12H, m).

Step 3: Synthesis of Compound I-3
Using Compound 3d (761 mg, 0.901 mmol), Compound I-3 (180 mg, 35% yield) was obtained in the same manner as in Step 8 of Example 1.
¹ H-NMR (DMSO-D ₆ ) δ: 3.60 (3H, s), 3.72-3.83 (2H, ABq, J = 24.2 Hz), 3.83 (1H, s), 4.05, 4.50 (2H, ABq, J = 18.0 Hz), 5.37 (1H, d, J = 4.9 Hz), 5.78 (1H, dd, J = 8.2, 4.7 Hz), 6.74 (1H, s), 7.23 (2H, s), 9.68 (1H, d, J = 8.1 Hz).

Example 4
Synthesis of Compound I-4

Step 1: Synthesis of Compound 4c Compound 4a (2.50 g, 5.82 mmol) (see WO2012 / 147773 for the synthesis method) was dissolved in dimethylacetamide (50 mL) and cooled to −20 degrees. Triethylamine (1.0 mL, 7.41 mmol) methanesulfonyl chloride (0.54 mL, 6.88 mmol) was added, and the mixture was stirred at −20 degrees for 20 minutes. Subsequently, 2,6-lutidine (1.85 mL, 15.9 mmol) and compound 4b (2.52 g, 5.29 mmol) were added and stirred for 2 hours under ice cooling. 1.0 mol / L hydrochloric acid was added, and the mixture was extracted with ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate, water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain crude compound 4c (5.6 g).
¹ H-NMR (CDCl ₃ ) δ: 8.29-8.23 (m, 2H), 7.39-7.25 (m, 12H), 6.47-6.47 (m, 1H), 5.99 (d, J = 1.2 Hz, 1H), 5.81 (dd, J = 8.6, 4.1 Hz, 1H), 5.37 (d, J = 4.1 Hz, 1H), 4.13-4.01 (m, 2H), 1.63 (s, 3H), 1.60 (s, 3H), 1.52 ( s, 9H), 1.43 (s, 9H).

Step 2: Synthesis of Compound 4d Crude compound 4c (5.5 g) was dissolved in tetrahydrofuran (300 mL) and water (100 mL) and stirred at 40 degrees for 4 hours. Water was added and extracted with ethyl acetate. The organic layer was washed with saturated brine and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain crude compound 4d (4.6 g).
¹ H-NMR (CDCl ₃ ) δ: 8.16 (d, J = 8.7 Hz, 1H), 7.38-7.21 (m, 12H), 6.33-6.32 (m, 1H), 5.90-5.89 (m, 1H), 5.81 (dd, J = 8.6, 4.0 Hz, 1H), 5.33 (d, J = 4.0 Hz, 1H), 4.08 (s, 2H), 1.61 (s, 3H), 1.59 (s, 3H), 1.52 (s, 9H), 1.43 (s, 9H).

Step 3: Synthesis of Compound 4e Compound 4d (2.08 g, 2.50 mmol) was dissolved in methylene chloride (10 mL), pyridine (0.44 mL, 5.50 mmol) was added, and then acetyl chloride (0. 39 mL, 5.50 mmol) was added and stirred for 1 hour. Water was added and extracted with methylene chloride. The organic layer was washed with saturated brine and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 4e (2.18 g, yield 100%).
¹ H-NMR (CDCl ₃ ) δ: 8.08 (d, J = 8.6 Hz, 1H), 7.41-7.26 (m, 12H), 6.46 (s, 1H), 5.85-5.79 (m, 2H), 5.37 (d , J = 4.2 Hz, 1H), 4.53 (d, J = 12.8 Hz, 1H), 4.44 (d, J = 12.8 Hz, 1H), 1.88 (s, 3H), 1.63 (s, 3H), 1.60 (s , 3H), 1.53 (s, 9H), 1.43 (s, 9H).

Step 4: Synthesis of Compound 4f Compound 4e (2.18 g, 2.49 mmol) was dissolved in methylene chloride (20 mL) and cooled to −50 degrees. mCPBA (0.728 g, 2.74 mmol) was added and stirred at −50 degrees for 30 minutes. Further, mCPBA (0.728 g, 2.74 mmol) was added and stirred at −50 degrees for 30 minutes. A 5% aqueous sodium hydrogen sulfate solution (80 mL) and ethyl acetate were added, and methylene chloride was distilled off. After the liquid separation operation, the organic layer was washed twice with 5% sodium bicarbonate water and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain compound 4f (1.58 g, yield 71%).
¹ H-NMR (CDCl ₃ ) δ: 7.91 (d, J = 9.9 Hz, 1H), 7.40-7.26 (m, 12H), 6.28 (dd, J = 9.9, 4.9 Hz, 1H), 5.31 (d, J = 13.6 Hz, 1H), 4.80 (d, J = 13.6 Hz, 1H), 4.72 (dd, J = 4.9, 1.4 Hz, 1H), 3.92 (d, J = 18.8 Hz, 1H), 3.33 (d, J = 18.8 Hz, 1H), 2.02 (s, 3H), 1.60 (s, 3H), 1.58 (s, 3H), 1.53 (s, 9H), 1.41 (s, 9H).

Step: Synthesis of Compound I-4 Compound 4f (0.890 g, 1.00 mmol) was dissolved in methylene chloride (10 mL) and cooled to −40 degrees. Phosphorus tribromide (0.28 mL, 3.00 mmol) was added and stirred at -40 degrees for 1 hour. Subsequently, anisole (1.1 mL, 10.0 mmol) and 2.0 mol / L aluminum chloride-nitromethane solution (5.0 mL, 10.0 mmol) were added and stirred at −20 ° C. for 1 hour. 0.2 mol / L hydrochloric acid and diisopropyl ether were added to the reaction solution. Acetonitrile and 0.2 mol / L hydrochloric acid water were added to the mixed solution to dissolve the residue. The aqueous layer was extracted from the organic layer, HP20SS was added, and the solution was concentrated under reduced pressure. The resulting suspension was subjected to ODS chromatography. Fractions containing the desired product were concentrated and lyophilized to obtain Compound I-4 (312 mg, 57% yield).
¹ H-NMR (DMSO-D ₆ ) δ: 9.51 (d, J = 8.4 Hz, 1H), 7.30 (br s, 2H), 6.72 (s, 1H), 5.86 (dd, J = 8.4, 5.0 Hz, 1H), 5.41 (d, J = 5.0 Hz, 1H), 4.93 (d, J = 12.7 Hz, 1H), 4.69 (d, J = 12.7 Hz, 1H), 3.76 (d, J = 18.1 Hz, 1H) , 3.65 (d, J = 18.1 Hz, 1H), 2.00 (d, J = 3.7 Hz, 3H), 1.45 (s, 3H), 1.43 (s, 3H).

(Example 5)
Synthesis of Compound I-5

Step 1: Synthesis of Compound 5b To a solution of Compound 5a (6.00 g, 6.23 mmol) and nicotinaldehyde (0.58 mL, 6.23 mmol) in methylene chloride (60 mL) was added 8.4% aqueous sodium bicarbonate (62.3 g, 62 .3 mmol) was added and stirred at room temperature for 5 hours. Further, nicotinaldehyde (0.58 mL, 6.23 mmol) was added and stirred at room temperature for 5 hours. Water was added and the mixture was extracted with methylene chloride and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain compound 5b (3.82 g, yield 97%).
¹ H-NMR (CDCl ₃ ) δ: 8.46-8.44 (m, 2H), 7.68-7.15 (m, 14H), 6.99-6.89 (m, 3H), 6.60 (d, J = 12.2 Hz, 1H), 6.54 (d, J = 12.2 Hz, 1H), 6.12 (dd, J = 9.9, 4.7 Hz, 1H), 4.62 (dd, J = 4.7, 1.4 Hz, 1H), 3.83 (s, 2H), 3.74 (d, J = 18.5 Hz, 1H), 3.03 (d, J = 18.5 Hz, 1H).

Step 2: Synthesis of Compound 5c Compound 5b (1.27 g, 2.00 mmol) was dissolved in dimethylformamide (12 mL) and cooled to −40 degrees. Phosphorus trichloride (0.26 mL, 3.00 mmol) was added and stirred at −40 degrees for 2 hours. Water was added, and the mixture was extracted with ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain compound 5c (0.627 g, yield 51%).
¹ H-NMR (CDCl ₃ ) δ: 8.49-8.44 (m, 2H), 7.70-6.97 (m, 14H), 6.52-6.47 (m, 2H), 6.39 (d, J = 11.9 Hz, 1H), 5.88 (dd, J = 5.0, 9.2 Hz, 1H), 5.13 (d, J = 5.0 Hz, 1H), 3.85 (s, 2H), 3.41 (d, J = 18.0 Hz, 1H), 3.23 (d, J = 18.0 Hz, 1H), 1.69 (s, 2H).

Step 3: Synthesis of Compound 5e Phosphorus pentachloride (0.317 g, 1.52 mmol) was dissolved in methylene chloride (15 mL), and pyridine (0.139 ml, 1.73 mmol) and compound 5c (0.627 g, 1.02 mmol) was added and stirred for 1 hour under ice cooling. The mixture was cooled to −40 ° C., methanol (2 mL) was added, and the mixture was stirred for 10 minutes under ice cooling. 5% aqueous sodium bicarbonate was added, extracted with methylene chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure until about 15 mL, compound 5d (0.427 g, 1.22 mmol) was added, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain compound 5e (0.270 g, yield 39%).
¹ H-NMR (DMSO-D ₆ ) δ: 9.62 (d, J = 8.7 Hz, 1H), 8.34-8.30 (m, 2H), 7.63 (s, 1H), 7.46-7.14 (m, 14H), 6.73 (s, 1H), 6.42 (d, J = 12.0 Hz, 1H), 6.30 (d, J = 12.0 Hz, 1H), 5.88-5.83 (m, 1H), 5.43 (d, J = 4.9 Hz, 1H) , 3.86-3.78 (m, 2H), 3.55 (s, 3H).

Step 4: Synthesis of Compound I-5 Compound 5e (0.270 g, 0.399 mmol) was dissolved in methylene chloride (5 mL) and cooled to −40 degrees. Anisole (0.87 mL, 7.98 mmol) and 2.0 mol / L aluminum chloride-nitromethane solution (4.0 mL, 7.98 mmol) were added and stirred for 1 hour under ice cooling. 0.2 mol / L hydrochloric acid and diisopropyl ether were added to the reaction solution, and acetonitrile and 0.2 mol / L hydrochloric acid water were added to the mixture to dissolve the residue. The aqueous layer was extracted from the organic layer, HP20SS was added, and the solution was concentrated under reduced pressure. The resulting suspension was subjected to ODS chromatography. Fractions containing the desired product were concentrated and lyophilized to obtain Compound I-5 (20 mg, yield 10%).
¹ H-NMR (DMSO-D ₆ ) δ: 9.61 (d, J = 8.1 Hz, 1H), 8.80 (d, J = 6.0 Hz, 1H), 8.65 (s, 1H), 8.17 (d, J = 7.9 Hz, 1H), 7.98-7.94 (m, 1H), 7.21 (s, 2H), 6.74 (s, 1H), 6.68 (d, J = 12.1 Hz, 1H), 6.47 (d, J = 12.1 Hz, 1H ), 5.79-5.75 (m, 1H), 5.42 (d, J = 4.9 Hz, 1H), 4.29 (s, 3H), 3.83 (s, 3H), 3.78-3.62 (m, 2H).

(Example 6)
Synthesis of Compound I-6

Step 1: Synthesis of Compound 6c Compound 6a (9.04 g, 30.0 mmol) was dissolved in DMA and cooled to −10 ° C. under a nitrogen atmosphere. To the solution was added triethylamine (4.16 mL, 30.0 mmol), followed by methanesulfonyl chloride (2.34 mL, 30.0 mmol) in one portion. The reaction solution was stirred at −10 ° C. for 30 minutes, and compound 4b (14.3 g, 30.0 mmol) and 2,6-lutidine (6.99 mmol, 60.0 mmol) were added and stirred for 1 hour. Purified water was added to the reaction solution, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with purified water and saturated brine, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the solvent was removed under reduced pressure to obtain Compound 6b (22.88 g).
The obtained compound 6b (22.88 g) was dissolved in dichloromethane (200 mL) and cooled to −40 ° C. 65% metachloroperbenzoic acid (11.9 g, 45.0 mmol) was added, and the mixture was stirred at −40 ° C. for 1 hour. A sodium thiosulfate aqueous solution was added to the reaction solution, dichloromethane was distilled off under reduced pressure, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with purified water and saturated brine, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, the solvent was removed under reduced pressure, and the resulting residue was subjected to silica gel chromatography to obtain compound 6c (18.08 g, yield 82%).
¹ H-NMR (CDCl ₃ ) δ: 8.71 (s, 1H), 7.87 (d, J = 9.9 Hz, 1H), 7.43-7.22 (m, 12H), 6.25 (dd, J = 9.9, 4.8 Hz, 1H ), 5.02 (d, J = 12.7 Hz, 1H), 4.74 (d, J = 4.8 Hz, 1H), 4.32 (d, J = 12.7 Hz, 1H), 4.05 (s, 3H), 3.91 (d, J = 18.4 Hz, 1H), 3.50 (d, J = 18.4 Hz, 1H), 1.53 (s, 9H).

Step 2: Synthesis of Compound 6d Under a nitrogen atmosphere, Compound 6c (18.1 g, 24.5 mmol) was dissolved in DMF (180 mL), cooled to −40 ° C., and phosphorus trichloride (3.21 mL, 36.7 mmol). And stirred at -40 degrees for 10 minutes. Purified water was added to the reaction solution, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with purified water, saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, the solvent was removed under reduced pressure, and the resulting residue was subjected to silica gel chromatography to obtain compound 6d (12.94 g, yield 73%).
¹ H-NMR (CDCl ₃ ) δ: 8.57 (br s, 1H), 7.42-7.17 (m, 12H), 6.05 (dd, J = 8.9, 5.0 Hz, 1H), 5.24 (d, J = 5.0 Hz, 1H), 4.59 (d, J = 12.4 Hz, 1H), 4.38 (d, J = 12.4 Hz, 1H), 4.08 (s, 3H), 3.76 (d, J = 18.5 Hz, 1H), 3.57 (d, J = 18.5 Hz, 1H), 1.51 (s, 9H).

Step 3: Synthesis of Compound I-6 Compound 6d (0.578 g, 0.800 mmol) was dissolved in DMF (2.40 mL) under a nitrogen atmosphere, cooled to −10 ° C., and sodium iodide (0.240 g, 1.60 mmol), 2-mercapto-1,3,4-thiadiazole (0.095 g, 0.800 mmol) and potassium carbonate (0.111 g, 0.800 mmol) were added, and the mixture was stirred at 10 ° C. for 3 hours. A 1 mmol / L hydrochloric acid aqueous solution was added to the reaction solution, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with purified water and saturated brine, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the solvent was removed under reduced pressure to obtain Compound 6e.
Compound 6e (643 mg, 0.800 mmol) was dissolved in dichloromethane (10.0 mL), cooled to −20 ° C., anisole (0.874 mL, 8.00 mmol), 2 mmol / L aluminum chloride nitromethane solution (4.00 mL, 8.00 mmol) was added and stirred at 0 ° C. 2 mmol / L aluminum chloride nitromethane solution (6.00 mL, 12.0 mmol) was further added to the reaction solution, and the mixture was stirred for 1 hour. Purified water (30 mL) and diisopropyl ether (50 mL) were added to the reaction solution. Acetonitrile, 2 mmol / L hydrochloric acid aqueous solution was added to the reaction solution to dissolve the precipitate, and then the aqueous layer was separated. The organic layer was extracted with a water / acetonitrile / dilute hydrochloric acid mixture, and HP20SS was added to the combined aqueous phase and concentrated. The concentrated suspension is subjected to HP20SS / ODS column chromatography, eluted with water-acetonitrile, the fraction containing the desired product is concentrated under reduced pressure, and the concentrated solution is lyophilized to obtain Compound I-6 as a powder. It was. (Yield 199 mg, Yield 46%)
¹ H-NMR (DMSO-D ₆ ) δ: 9.68 (d, J = 8.0 Hz, 1H), 9.50 (s, 1H), 7.22 (s, 2H), 6.74 (s, 1H), 5.77 (dd, J = 8.0, 4.9 Hz, 1H), 5.36 (d, J = 4.9 Hz, 1H), 4.70 (d, J = 13.7 Hz, 1H), 4.26 (d, J = 13.7 Hz, 1H), 3.93-3.69 (m , 5H).

(Example 7)
Synthesis of Compound I-7

Step 1: Synthesis of Compound 7c Compound 7c was synthesized in the same manner as in Step 1 of Example 6 using Compound 7a and Compound 4b.
¹ H-NMR (CDCl ₃ ) δ: 8.46 (br s, 1H), 7.42-7.26 (m, 12H), 6.05 (dd, J = 9.1, 4.9 Hz, 1H), 5.24 (d, J = 4.9 Hz, 1H), 4.58 (d, J = 12.1 Hz, 1H), 4.43-4.31 (m, 3H), 3.77 (d, J = 18.1 Hz, 1H), 3.57 (d, J = 18.1 Hz, 1H), 1.52 ( s, 9H), 1.35 (t, J = 7.0 Hz, 3H).

Step 2: Synthesis of Compound I-7 Compound I-7 was synthesized in the same manner as in Step 2 and then Step 3 of Example 6 using Compound 7c.
¹ H-NMR (DMSO-D ₆ ) δ: 9.65 (d, J = 8.2 Hz, 1H), 7.22 (br s, 2H), 6.72 (s, 1H), 5.80 (dd, J = 8.1, 4.9 Hz, 1H), 5.38 (d, J = 4.9 Hz, 1H), 4.50 (d, J = 13.8 Hz, 1H), 4.17-4.03 (m, 3H), 3.89 (s, 2H), 3.84 (d, J = 18.1 Hz, 1H), 3.71 (d, J = 18.1 Hz, 1H), 1.22 (t, J = 14.1 Hz, 3H).

(Example 8)
Synthesis of Compound I-8

Step 1: Synthesis of Compound I-8 Compound I-8 was synthesized in the same manner as in Step 3 of Example 6 using Compound 6d.
¹ H-NMR (DMSO-D ₆ ) δ: 9.72 (d, J = 8.1 Hz, 1H), 7.35 (br s, 2H), 7.25 (br s, 2H), 6.78 (s, 1H), 5.79 (dd , J = 8.1, 4.9 Hz, 1H), 5.36 (d, J = 4.9 Hz, 1H), 4.49 (d, J = 13.8 Hz, 1H), 4.04 (d, J = 13.8 Hz, 1H), 3.89 (d , J = 17.6 Hz, 1H), 3.87 (s, 3H), 3.72 (d, J = 17.6 Hz, 1H).

Example 9
Synthesis of Compound I-9

Step 1: Synthesis of Compound I-9 Compound I-9 was synthesized in the same manner as in Step 3 of Example 6 using Compound 6d.
¹ H-NMR (DMSO-D ₆ ) δ: 9.68 (d, J = 8.1 Hz, 1H), 7.24 (br s, 2H), 6.74 (s, 1H), 5.75 (dd, J = 8.1, 4.8 Hz, 1H), 5.32 (d, J = 4.8 Hz, 1H), 4.44 (d, J = 13.4 Hz, 1H), 3.98 (d, J = 13.3 Hz, 1H), 3.85 (d, J = 17.8 Hz, 1H) , 3.83 (s, 3H), 3.69 (d, J = 17.8 Hz, 2H).

(Example 10)
Synthesis of Compound I-10

Step 1: Synthesis of Compound 10c Compound 10c was synthesized in the same manner as in Step 1 of Example 6 using Compound 10a and Compound 4b.
¹ H-NMR (CDCl ₃ ) δ: 9.27 (br s, 1H), 8.09 (d, J = 9.1 Hz, 1H), 7.39-7.26 (m, 11H), 6.20 (dd, J = 9.1, 4.6 Hz, 1H), 4.98 (d, J = 12.3 Hz, 1H), 4.76 (d, J = 4.6 Hz, 1H), 4.34 (d, J = 12.3 Hz, 1H), 4.04 (s, 3H), 3.88 (d, J = 18.7 Hz, 1H), 3.51 (d, J = 18.7 Hz, 1H), 1.53 (s, 9H).

Step 2: Synthesis of Compound 10d Compound 10d was synthesized in the same manner as in Step 2 of Example 6 using Compound 10c.
¹ H-NMR (CDCl ₃ ) δ: 8.69 (s, 1H), 7.55 (d, J = 8.2 Hz, 1H), 7.44-7.23 (m, 11H), 6.04 (dd, J = 8.8, 5.1 Hz, 1H ), 5.24 (d, J = 5.1 Hz, 1H), 4.58 (d, J = 11.9 Hz, 1H), 4.40 (d, J = 11.9 Hz, 1H), 4.10 (s, 3H), 3.78 (d, J = 18.3 Hz, 1H), 3.58 (d, J = 18.3 Hz, 1H), 1.47 (s, 9H).

Step 3: Synthesis of Compound I-10 Compound I-10 was synthesized in the same manner as in Step 3 of Example 6 using Compound 10d.
¹ H-NMR (DMSO-D ₆ ) δ: 9.65 (d, J = 8.4 Hz, 1H), 7.37 (s, 2H), 5.78 (dd, J = 8.4, 4.9 Hz, 1H), 5.34 (d, J = 4.9 Hz, 1H), 4.50 (d, J = 13.8 Hz, 1H), 4.05 (d, J = 13.8 Hz, 1H), 3.92-3.67 (m, 5H), 3.60 (s, 3H).

(Example 11)
Synthesis of Compound I-11

Step 1: Synthesis of Compound 11c Compound 11c was synthesized in the same manner as in Step 1 of Example 6 using Compound 11a and Compound 4b.
¹ H-NMR (CDCl ₃ ) δ: 8.35 (s, 1H), 7.67 (d, J = 9.9 Hz, 1H), 7.46-7.16 (m, 26H), 6.28 (dd, J = 9.9, 4.9 Hz, 1H ), 5.02 (d, J = 12.5 Hz, 1H), 4.60 (dd, J = 4.9, 1.3 Hz, 1H), 4.26 (d, J = 12.5 Hz, 1H), 3.73 (d, J = 18.5 Hz, 1H) ), 3.28 (d, J = 18.5 Hz, 1H), 1.48 (s, 9H).

Step 2: Synthesis of Compound 11d Compound 11d was synthesized in the same manner as in Step 2 of Example 6 using Compound 11c.
¹ H-NMR (CDCl ₃ ) δ: 8.03 (s, 1H), 7.40-7.23 (m, 26H), 6.07 (dd, J = 8.5, 4.9 Hz, 1H), 5.18 (d, J = 4.9 Hz, 1H ), 4.55 (d, J = 11.8 Hz, 1H), 4.36 (d, J = 11.8 Hz, 1H), 3.68 (d, J = 18.0 Hz, 1H), 3.42 (d, J = 18.0 Hz, 1H), 1.50 (s, 9H).

Step 3: Synthesis of Compound I-11 Compound I-11 was synthesized in the same manner as in Step 3 of Example 6 using Compound 11d.
¹ H-NMR (DMSO-D ₆ ) δ: 11.73 (s, 1H), 9.49 (d, J = 8.6 Hz, 1H), 7.26 (s, 2H), 5.80 (dd, J = 8.6, 5.0 Hz, 1H ), 5.33 (d, J = 5.0 Hz, 1H), 4.50 (d, J = 13.6 Hz, 1H), 4.05 (d, J = 13.6 Hz, 1H), 3.81 (d, J = 18.0 Hz, 1H), 3.69 (d, J = 18.0 Hz, 1H), 3.60 (s, 3H).

Example 12
Synthesis of Compound I-12 (4-position tetrazole of cefditorene)

Step 1: Synthesis of Compound 12d
Compound 12a (11.29 g, 19.4 mmol) (see WO2012 / 147773 for the synthesis method) was dissolved in methylene chloride (120 mL) and 65% -m-chloroperbenzoic acid (7.74 g, A solution of 29.1 mmol) in methylene chloride (50 mL) was added and stirred for 1 hour. Next, an aqueous solution of sodium thiosulfate (3.07 g, 19.4 mmol) was added to the reaction solution. Next, ethyl acetate was added, and the mixture was concentrated under reduced pressure. The precipitated solid was collected by filtration to obtain Compound 12b (6.09 g, yield 54%).
Compound 12b (4.92 g, 8.50 mmol) was then dissolved in dimethylformamide (20 mL) and sodium iodide (2.55 g, 17.0 mmol) was added, followed by triphenylphosphine (2.67 g, 10.5 mmol). 2 mmol) was added. The reaction mixture was stirred at room temperature for 30 minutes, isopropyl ether (70 m) and water (100 mL) were added, and the precipitated solid was collected by filtration to give compound 5a (8.19 g, yield 103%).
To a solution of Compound 5a (1.93 g, 2.1 mmol) and Compound 12c (0.763 g, 6.0 mmol) in methylene chloride (20 mL) was added 8.4% -aqueous sodium hydrogen carbonate solution at room temperature for 20 hours. Stir. Next, the methylene chloride layer was separated and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The resulting residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain compound 12d (1.17 g, yield 87%).
¹ H-NMR (CDCl ₃ ) δ: 2.31 (3H, s), 3.18, 3.75 (2H, ABq, J = 24.8 Hz), 3.85 (2H, s), 4.70 (1H, d, J = 4.7 Hz), 6.15 (1H, dd, J = 10.0, 4.8 Hz), 6.33 (1H, d, J = 11.7 Hz), 6.53 (1H, d, J = 11.7 Hz), 6.92-7.69 (22H, m), 8.51 (1H , s).

Step 2: Synthesis of Compound 12e Compound 12e was synthesized in the same manner as in Step 2 of Example 6 using Compound 12d.
¹ H-NMR (CDCl ₃ ) δ: 8.52 (s, 1H), 7.69-6.98 (m, 14H), 6.48 (d, J = 11.4 Hz, 1H), 6.28 (d, J = 9.2 Hz, 1H), 6.21 (d, J = 11.4 Hz, 1H), 5.90 (dd, J = 9.2, 4.8 Hz, 1H), 5.22 (d, J = 4.8 Hz, 1H), 3.86 (s, 2H), 3.53 (d, J = 17.9 Hz, 1H), 3.32 (d, J = 17.9 Hz, 1H), 2.29 (s, 3H).

Step 3: Synthesis of Compound 12g Under nitrogen atmosphere, phosphorus pentachloride (0.643 g, 3.09 mmol) was suspended in dichloromethane (7.5 mL), cooled to 0 ° C., and pyridine (0.274 mL, 3.40 mmol). ) And compound 12e (985 mg, 1.54 mmol) were added and stirred at 0 ° C. After completion of the reaction, the reaction solution was cooled to −40 ° C., and methanol (3.13 mL, 77.0 mmol) was added at once. The temperature was raised to room temperature, purified water was added to the reaction solution, and the organic layer was washed with purified water and saturated aqueous sodium hydrogen carbonate, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, compound 12f (0.649 g, 1.86 mmol) was added to the resulting dichloromethane solution, and the mixture was stirred at room temperature. After completion of the reaction, saturated aqueous sodium hydrogen carbonate was added to the reaction mixture, dichloromethane was distilled off under reduced pressure, and the aqueous layer was extracted with ethyl acetate. The obtained organic layer was washed with purified water and saturated brine, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, the solvent was removed under reduced pressure, and the resulting residue was subjected to silica gel chromatography to obtain 12 g (0.521 g, yield 48%) of the compound.
¹ H-NMR (CDCl ₃ ) δ: 8.53 (s, 1H), 7.45-7.08 (m, 11H), 6.90 (s, 1H), 6.51 (d, J = 11.6 Hz, 1H), 6.24 (d, J = 11.6 Hz, 1H), 6.07 (dd, J = 8.8, 4.9 Hz, 1H), 5.34 (d, J = 4.9 Hz, 1H), 5.23 (br s, 2H), 4.07 (s, 3H), 3.58 ( d, J = 18.3 Hz, 1H), 3.38 (d, J = 18.3 Hz, 1H), 2.31 (s, 3H).

Step 4: Synthesis of Compound I-12 Compound 12g (521 mg, 0.748 mmol) was dissolved in dichloromethane (5.00 mL), cooled to −20 ° C., anisole (0.817 mL, 7.48 mmol), 2 mmol / L Aluminum chloride A nitromethane solution (3.74 mL, 7.48 mmol) was added, and the mixture was stirred at 0 ° C. Anisole (0.817 mL, 7.48 mmol) and 2 mmol / L aluminum chloride nitromethane solution (3.74 mL, 7.48 mmol) were further added to the reaction solution, and the mixture was stirred for 1 hour. Purified water (30 mL) and diisopropyl ether (50 mL) were added to the reaction solution. Acetonitrile, 2 mmol / L hydrochloric acid aqueous solution was added to the reaction solution to dissolve the precipitate, and then the aqueous layer was separated. The organic layer was extracted with a water / acetonitrile / dilute hydrochloric acid mixture, and HP20SS was added to the combined aqueous phase and concentrated. The concentrated suspension is subjected to HP20SS / ODS column chromatography, eluted with water-acetonitrile, the fraction containing the target compound is concentrated under reduced pressure, and the concentrated solution is lyophilized to obtain Compound I-12 as a powder. It was. (Yield 240 mg, 61% yield)
¹ H-NMR (DMSO-D ₆ ) δ: 9.72 (d, J = 8.0 Hz, 1H), 8.91 (s, 1H), 7.22 (br s, 2H), 6.74 (s, 1H), 6.65 (d, J = 11.7 Hz, 1H), 6.28 (d, J = 11.7 Hz, 1H), 5.85 (dd, J = 8.0, 4.6 Hz, 1H), 5.47 (d, J = 4.6 Hz, 1H), 3.84 (s, 3H), 3.62 (d, J = 17.3 Hz, 1H), 3.54 (d, J = 17.3 Hz, 1H), 2.24 (s, 3H).

(Example 13)
Synthesis of Compound I-13

Step 1: Synthesis of Compound 13c Compound 13a (520 mg, 1.04 mmol) (see WO2013 / 2215 for the synthesis method) was dissolved in methylene chloride (8 mL), and Compound 13b (346 mg, 1.15 mmol), WSCD (260 mg, 1.36 mmol) was added, and the mixture was stirred for 1 hour under ice cooling. Diluted with ethyl acetate, washed with water, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (methylene chloride-ethyl acetate) to give compound 13c (730 mg, yield 90%).
¹ H-NMR (CDCl ₃ ) δ: 1.52 (s, 9H), 3.42 and 3.59 (ABq, J = 18.0Hz, 2H), 3.76 (s, 3H), 3.80 (s, 3H), 4.05 and 4.14 (ABq , J = 7.2Hz, 2H), 4.97 (d, J = 5.1Hz, 1H), 5.49 (s, 2H), 5.85 (dd, J = 9.0, 4.8Hz, 1H), 6.43-6.46 (m, 2H) , 6.99-7.02 (m, 3H), 7.24 (d, J = 9.9Hz, 2H), 7.56 (d, J = 2Hz, 1H), 8.34-8.38 (m, 2H), 8.62 (bs, 1H).

Step 2: Synthesis of Compound I-13 Compound 13c (200 mg, 0.25 mmol) was dissolved in methylene chloride (0.5 mL), anisole (0.37 ml) was added, and then trifluoroacetic acid (4 ml) was added. Stir. The mixture was concentrated under reduced pressure, ethyl ether (10 ml) was added, and the mixture was powdered and collected by filtration. Purification by HP-20 column chromatography and lyophilization gave compound I-13 (103 mg).
¹ H-NMR (DMSO-d ₆ ) δ: 3.56 and 3.81 (ABq, J = 17.4Hz, 2H), 3.84 (s, 3H), 4.14 and 4.39 (ABq, J = 13.2Hz, 2H), 5.36 (d , J = 4.8Hz, 1H), 5.75 (dd, J = 4.8 and 8.1Hz, 1H), 6.75 (s, 1H), 7.22 (d, J = 5.4Hz, 4H), 8.35 (d, J = 5.1Hz , 2H), 9.68 (d, J = 8.1Hz, 1H)

(Example 14)
Synthesis of Compound I-14

Step 1: Synthesis of Compound I-14 Ethyl iodide (0.3 mL) was added to a solution of Compound 13c (250 mg, 0.32 mmol) in dimethylformamide (2 mL), and the mixture was stirred at room temperature for 15 hours. The precipitate formed by pouring into brine was collected by filtration, dissolved in methylene chloride, washed with water, and concentrated under reduced pressure to obtain crude compound 14a. This was dissolved in a methylene chloride (1 mL) solution, anisole (0.2 mL) and then trifluoroacetic acid (4 ml) were added, and the mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, ethyl ether (10 mL) was added, and the mixture was powdered and collected by filtration. Purification by HP-20 column chromatography and lyophilization gave Compound I-14 (104 mg).
1H-NMR (DMSO-d6) δ: 1.43 (t, J = 7.2Hz, 3H), 3.55 and 3.67 (ABq, J = 17.4Hz, 2H), 3.95 (s, 3H), 4.38 and 4.63 (ABq, J = 12.6Hz, 2H), 5.25 (d, J = 4.2Hz, 1H), 5.71 (dd, J = 4.2, 8.4Hz, 1H), 7.11 (bs, 2H), 7.45 (s, 1H), 7.82 (d , J = 6.9Hz, 2H), 8.67 (d, J = 6.9Hz, 2H), 9.40 (d, J = 8.1Hz, 1H)

(Example 15)
Synthesis of Compound I-15

Step 1: Synthesis of Compound I-15 Ethyl iodide (0.4 mL) was added to a solution of Compound 15a (220 mg) (see WO2013 / 2215 for the synthesis method) in dimethylformamide (1.5 mL) and stirred at room temperature for 18 hours. . The precipitate formed by pouring into brine was collected by filtration, dissolved in methylene chloride, washed with water, and concentrated under reduced pressure to give crude compound 15b (217 mg). This was dissolved in a methylene chloride (0.8 mL) solution, anisole (0.2 mL) and then trifluoroacetic acid (5 ml) were added, and the mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, ethyl ether (10 mL) was added, and the mixture was powdered and collected by filtration. Purification by HP-20 column chromatography and lyophilization gave Compound I-15 (81 mg).
1H-NMR (DMSO-d6) δ: 1.43 (s, 3H), 1.45 (s, 3H), 1.45-1.51 (m, 3H), 3.58 and 3.70 (ABq, J = 17.4Hz, 2H), 4.34 and 4.64 (ABq, J = 13.3Hz, 2H), 4.37-4.40 (m, 2H), 5.29 (d, J = 4.8, Hz, 1H), 5.75 (dd, J = 4.8, 8.1Hz, 1H), 6.73 (s , 1H), 7.29 (bs, 2H), 7.78 (d, J = 7.2Hz, 2H), 8.65 (d, J = 7.2Hz, 2H), 9.40 (d, J = 8.1Hz, 1H)

(Example 16)
Synthesis of Compound I-16

Step 1: Synthesis of Compound I-16 Compound 15a (300 mg) (see WO2013 / 2215 for the synthesis method) in dimethylformamide (2 mL) in N-Boc-bromoethylamine (0.47 g) and potassium iodide (0. Add 82g) and stir at 50 degrees for 4 hours. Water and ethyl acetate are added for liquid separation, and the organic layer is washed with water. Concentration under reduced pressure gave crude compound 16a as an oil. This was dissolved in a methylene chloride (2 mL) solution, anisole (0.2 mL) and then trifluoroacetic acid (4 mL) were added, and the mixture was stirred at room temperature for 40 minutes. Concentrate under reduced pressure, add ethyl ether (10 mL) to powder and collect by filtration. Purification by HP-20 column chromatography and lyophilization gave compound I-16 (43 mg).
1H-NMR (DMSO-d6) δ: 1.41 (s, 3H), 1.47 (s, 3H), 3.60-3.90 (m, 6H), 4.02 and 4.25 (ABq, J = 13.2Hz, 2H), 5.35 (d , J = 4.8, Hz, 1H), 5.87 (dd, J = 4.8, 8.1Hz, 1H), 6.69 (s, 1H), 7.16 (d, J = 6.0Hz, 2H), 7.28 (bs, 2H), 8.31 (d, J = 6.0Hz, 2H)

(Example 17)
Synthesis of Compound I-17

Step 1: Synthesis of Compound I-17 Bromoacetaldehyde (68 mg) was added to a solution of Compound 15a (300 mg) in dimethylformamide (2 mL) and stirred at 40 ° C. for 2.5 hours. The precipitate that was poured into water and deposited was collected by filtration. Dissolve in methylene chloride, wash with water, and concentrate under reduced pressure to obtain crude compound 17a. This was dissolved in a methylene chloride (2 mL) solution, anisole (0.3 mL) and then trifluoroacetic acid (4 mL) were added, and the mixture was stirred at room temperature for 40 minutes. The mixture was concentrated under reduced pressure, ethyl ether (10 mL) was added, and the mixture was powdered and collected by filtration. Purification by HP-20 column chromatography and lyophilization gave Compound I-17 (107 mg).
1H-NMR (DMSO-d6) δ: 1.42 (s, 3H), 1.45 (s, 3H), 3.54 and 3.72 (ABq, J = 17.1Hz, 2H), 4.34 and 4.65 (ABq, J = 13.5Hz, 2H ), 5.16 (s, 2H), 5.30 (d, J = 4.8Hz, 1H), 5.75 (dd, J = 4.8, 8.4Hz, 1H), 6.73 (s, 1H), 7.28 (bs, 2H), 7.63 (bs, 1H), 7.75 (d, J = 7.2Hz, 2H), 7.75 (bs, 1H), 8.50 (d, J = 7.2Hz, 2H)

(Example 18)
Synthesis of Compound I-18

Step 1: Synthesis of Compound I-18 Ethyl iodide (0.4 mL) is added to a solution of Compound 18a (690 mg) (see WO2013 / 2215 for the synthesis method) in dimethylformamide (2 mL) and stirred at room temperature for 15 hours. The gum-like substance poured into water and precipitated was collected by filtration and washed with water. Dissolve in methylene chloride, wash with water, and concentrate under reduced pressure to obtain crude compound 18b. This is dissolved in a solution of methylene chloride (5 mL), anisole (0.45 mL) and then trifluoroacetic acid (3 ml) are added and stirred at room temperature for 1 hour. Concentrate under reduced pressure, add ethyl ether (10 mL) to powder and collect by filtration. Purification by HP-20 column chromatography and lyophilization gave Compound I-18 (80 mg).
1H-NMR (DMSO-d6) δ: 1.40-1.52 (m, 9H), 4.40-4.78 (m, 6H), 5.32 (d, J = 3.6Hz, 1H), 5.61 (dd, J = 3.6, 9.0Hz , 1H), 6.79 (s, 1H), 7.27 (bs, 2H), 7.89 (d, J = 6.3Hz, 2H), 8.60 (d, J = 6.3Hz, 2H), 9.03 (d, J = 9.0Hz , 1H)

(Example 19)
Synthesis of Compound I-19

Step 1: Synthesis of Compound I-19 Compound 19b (210 mg) and sodium bromide (165 mg) were added to a dimethylformamide (2 mL) solution of Compound 19a (550 mg) (see WO2013 / 2215 for the synthesis method) at room temperature for 15 hours. Stir. The mixture was poured into water and the precipitated material was collected by filtration and washed with water. Dissolve in methylene chloride, wash with water, and concentrate under reduced pressure to obtain crude compound 19c (0.66 g). This is dissolved in a methylene chloride (6 mL) solution, anisole (0.45 mL) and then trifluoroacetic acid (2 mL) are added, and the mixture is stirred at room temperature for 1 hour. Concentrate under reduced pressure, add ethyl ether (10 mL) to powder and collect by filtration. Purification by HP-20 column chromatography and lyophilization gave compound I-19 (59 mg).
MS (ESI): 733.32 ⁺ (M + H) ⁺

(Example 20)
Synthesis of Compound I-20

Sodium iodide (300 mg, 2.00 mmol) was added to a solution of compound 3a (722 mg, 1.00 mmol) in dimethylformamide (2.0 mL), and the mixture was stirred at room temperature for 5 minutes. After cooling to 0 ° C., Compound 20a (125 mg, 1.05 mmol) was added, followed by stirring at room temperature for 2 hours. Dimethylformamide (6.0 mL) was added for dilution, and the reaction mixture was slowly added to ice-cooled 5% brine containing sodium thiosulfate (1 g). The precipitated solid was collected by filtration, washed with water, and dried to give compound 20b as a pale yellow solid (765 mg). The obtained compound 20b was used in the next reaction without purification.
The obtained compound 20b was dissolved in methylene chloride (10 ml) and cooled to −40 ° C., then anisole (1.56 ml, 14.3 mmol) and 2 mol / L aluminum chloride / nitromethane solution (7.13 ml, 14.3 mmol) were sequentially added. In addition, the mixture was stirred at 0 ° C. for 6 hours. The reaction solution was dissolved in water, a 2 mol / L aqueous hydrochloric acid solution, and acetonitrile, and then washed with diisopropyl ether. HP20-SS resin was added to the aqueous layer, and acetonitrile was distilled off under reduced pressure. The resulting mixture was purified by ODS column chromatography. After adding 0.2 mol / L sodium hydroxide aqueous solution to pH = 6.0 to the obtained solution of the target compound, 1 piece of dry ice was added. The obtained solution was concentrated under reduced pressure and then lyophilized to obtain Compound I-20 as a white powder. (Yield 95.5 mg, Yield 19%)
¹ H-NMR (DMSO-D ₆ ) δ: 9.65 (1H, d, J = 8.2 Hz), 7.20 (2H, br s), 6.74 (1H, br s), 5.76 (1H, dd, J = 8.2, 4.9 Hz), 5.35 (1H, d, J = 4.9 Hz), 4.46 (1H, d, J = 13.3 Hz), 4.19-3.36 (10H, m).

(Example 21)
Synthesis of Compound I-21

Compound 15a (180 mg) was dissolved in methylene chloride (0.8 ml) and anisole (0.2 ml) was added. TFA (5 ml) was added, and the mixture was stirred at room temperature for 1 hr and concentrated under reduced pressure. Ether was added to the residue and the resulting precipitate was collected by filtration. Purification by HP-20 column chromatography and lyophilization gave Compound I-21 (80 mg).
¹ H-NMR (d6-DMSO) δ: 1.43 (3H, s), 1.45 (3H, s), 3.59-3.77 (2H, AB-q, J = 17.7 Hz), 3.77, 4.11 (2H, AB-q , J = 13.2 Hz), 5.33 (1H, s), 5.78 (1H, dd, J = 4.8, 8.1 Hz), 6.73 (1H, s), 7.13 (2H, d, J = 5.4 Hz), 8.33 (2H , d, J = 4.7 Hz), 9.42 (1H, d, J = 8.4 Hz)
MS (ESI): 603.4 ⁺ (M + H) ⁺

(Example 22)
Synthesis of Compound I-22

TFA (5 ml) was added to a solution of compound 18a (500 mg) and anisole (0.35 ml) in methylene chloride (5 ml), and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, ether was added and powdered and collected by filtration. Purification by HP-20 column chromatography and lyophilization gave I-22 (70 mg).
¹ H-NMR (d6-DMSO) δ: 1.39 (3H, s), 1.41 (3H, s), 4.24, 4.49 (2H, AB-q, J = 13.5 Hz), 4.61 (2H, bs), 5.38 ( 1H, d, J = 3.9 Hz), 5.65 (1H, dd, J = 3.8, 8.7 Hz), 6.76 (1H, s), 7.23 (2H, d, J = 5.4 Hz), 7.29 (1H, s), 8.32 (2H, d, J = 5.1 Hz), 9.13 (1H, d, J = 9.0 Hz)
MS (ESI): 587.2 ⁺ (M + H) ⁺

(Example 23)
Synthesis of Compound I-23

Compound 19a (300 mg) was dissolved in methylene chloride (5 ml), anisole (9.3 ml) and TFA (1.5 ml) were added, and the mixture was stirred at room temperature for 1.5 hours. The product was treated by a conventional method, purified by HP-20 chromatography and freeze-dried to obtain I-23 (45 mg).
¹ H-NMR (d6-DMSO) δ: 1.36 (3H, d, J = 6.9 Hz), 4.25, 4.50 (2H, AB-q, J = 13.8 Hz), 4.55-4.65 (1H, m), 4.60 ( 2H, bs), 5.37 (1H, d, J = 3.9 Hz), 5.65 (1H, dd, J = 3.9, 9.0 Hz), 7.24 (2H, d, J = 5.1 Hz), 7.43 (2H, bs), 8.32 (2H, d, J = 4.5 Hz), 9.17 (1H, d, J = 9.3 Hz)
MS (ESI): 607.2 ⁺ (M + H)

(Example 24)
Synthesis of Compound I-24

Compound 19a (440 mg) was dissolved in DMF (1.5 ml), iodoethane (0.3 ml) was added, and the mixture was stirred at room temperature for 18 hours. The gum-like substance produced by pouring into brine was collected, dissolved in methylene chloride, washed with water, dried and concentrated. The residue was dissolved in methylene chloride (5 ml), anisole (0.4 ml) and TFA (1.5 ml) were added, and the mixture was stirred at room temperature for 2 hours. The product was treated by a conventional method, purified by HP-20 chromatography and lyophilized to obtain I-24 (60 mg).
MS (ESI): 635.33+ (M + H) +

(Example 25)
Synthesis of Compound I-25

Compound 25a (100 mg) (see WO2013 / 2215 for the synthesis method) and anisole (0.12 ml) were dissolved in methylene chloride (1 ml), TFA (1.5 ml) was added at room temperature, and the mixture was stirred for 1.5 hours. Concentrated, added ether and filtered to powder. Purification by HP-20 column chromatography and lyophilization gave I-25 (28 mg).
¹ H-NMR (d6-DMSO) δ: 1.41 (3H, s), 1.50 (3H, s), 3.37, 3.93 (2H, AB-q, J = 17.4 Hz), 5.50 (1H, d, J = 5.1 Hz), 5.83 (1H, dd, J = 5.1, 8.1 Hz), 6.72 (1H, s), 7.15-7.25 (4H, m), 8.35 (2H, dd, J = 6.0 Hz)
MS (ESI): 589.2 ⁺ (M + H) ⁺

(Example 26)
Synthesis of Compound I-26 (Cefdinir 4-position tetrazole)

Step 1:
Compound 1a (14.26 g, 30 mmol) was suspended in ethyl acetate (143 mL), and 2,6-lutidine (8.74 ml, 75 mmol) and 2-phenylacetyl chloride (5.20 mL, 39 mmol) were added at 0 ° C. Added sequentially. The reaction solution was stirred at 0 ° C. for 1 hour, diluted hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, sodium bicarbonate water and saturated brine in this order, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Isopropyl ether was added to the obtained residue, and the precipitated solid was collected by filtration to obtain Compound 26a (15.37 g, yield 92%).
¹ H-NMR (CDCl ₃ ) δ: 3.64, 3.67 (2H, ABq, J = 16.0 Hz), 4.02, 4.07 (2H, ABq, J = 12.2 Hz), 5.26 (1H, d, J = 4.0 Hz), 5.63 (1H, dd, J = 8.7, 3.9 Hz), 5.94 (1H, s), 6.19 (1H, d, J = 8.6 Hz), 6.41 (1H, s), 7.23-7.41 (16H, m).

Step 2:
Compound 26a (15.36 g, 27.6 mmol) was dissolved in methylene chloride (80 mL), and 65% -m-chloroperbenzoic acid (8.05 g, 30.3 mmol) in methylene chloride (80 ml) at −50 ° C. The solution was added. The reaction solution was stirred at −50 ° C. for 30 minutes, and a solution of sodium thiosulfate (2.18 g, 13.79 mmol) and sodium bicarbonate (3.47 g, 41.4 mmol) in water (100 ml) was added, and then methylene chloride. The layers were separated. The methylene chloride layer was washed twice with aqueous sodium bicarbonate, and a solid precipitated. Therefore, ethyl acetate was added and concentrated, and the solid was collected by filtration to obtain Compound 26b (13.22 g, yield 84%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.54, 3.69 (2H, ABq, J = 13.8 Hz), 3.75, 4.01 (2H, ABq, J = 18.2 Hz), 4.67, 4.50 (2H, ABq, J = 11.8 Hz), 5.08 (1H, d, J = 4.5 Hz), 5.90 (1H, dd, J = 8.2, 4.9 Hz), 7.24-7.44 (18H, m), 7.83 (1H, s), 8.45 (1H, d, J = 8.1 Hz).

Step 3:
Compound 26b (13.2 g, 23 mmol) was suspended in dimethylformamide (106 mL), and phosphorus trichloride (6.04 ml, 69.1 mmol) was added at −50 ° C. The reaction mixture was stirred at −40 ° C. for 1 hour, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, sodium bicarbonate water and saturated brine in this order, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Ethyl acetate and isopropyl ether were added to the resulting residue and the mixture was stirred at room temperature, and the precipitated solid was collected by filtration to give compound 26c (9.03 g, yield 70%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.48, 3.55 (2H, ABq, J = 14.0 Hz), 3.65, 3.78 (2H, ABq, J = 18.0 Hz), 4.43, 4.45 (2H, ABq, J = 11.6 Hz), 5.31 (1H, d, J = 4.8 Hz), 5.76 (1H, dd, J = 8.3, 5.1 Hz), 7.23-7.43 (15H, m), 7.81 (1H, s), 9.14 (1H, d, J = 8.3 Hz).

Step 4:
Compound 26c (9.01 g, 16.17 mmol) was dissolved in dimethylformamide (45 mL) and sodium iodide (4.85 g, 32.3 mmol) was added followed by triphenylphosphine (5.09 g, 19.4 mmol). . The reaction solution was stirred at room temperature for 30 minutes, and then poured into a stirring solution of isopropyl ether (100 ml) and water (200 ml). The precipitated solid was collected by filtration to obtain Compound 26d (14.94 g, yield 101%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.48-3.58 (4H, m), 4.76-4.76 (2H, m), 5.37 (1H, d, J = 4.8 Hz), 5.69 (1H, dd, J = 7.7, 4.9 Hz), 7.19-7.79 (31H, m), 9.09 (1H, d, J = 8.1 Hz).

Step 5:
Compound 26d (14.49 g, 15.91 mmol) was dissolved in methylene chloride (145 mL), and 2 mol / L-sodium hydroxide aqueous solution (39.8 mL, 80 ml) was added at 0 ° C. The reaction solution was stirred at 0 ° C. for 50 minutes, and then the methylene chloride layer was separated. The methylene chloride layer was dried with magnesium sulfate.
Formaldehyde gas generated by thermally decomposing paraformaldehyde (4.78 g) was passed through the resulting methylene chloride solution. The resulting solution was stirred overnight at room temperature, and then the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, the solvent was distilled off under reduced pressure, and a mixture of ethyl acetate / hexane = 3/7 was added to the resulting solid and collected by filtration to give compound 26e (2.14 g, yield 25). %).
¹ H-NMR (CDCl ₃ ) δ: 3.53, 3.70 (2H, ABq, J = 17.6 Hz), 3.61, 3.67 (2H, ABq, J = 16.0 Hz), 5.11 (1H, d, J = 4.8 Hz), 5.22 (1H, d, J = 11.1 Hz), 5.39 (1H, d, J = 17.4 Hz), 5.85 (1H, dd, J = 9.1, 4.8 Hz), 6.06 (1H, d, J = 9.1 Hz), 6.83 (1H, dd, J = 17.4, 11.1 Hz), 7.26-7.38 (19H, m).

Step 6:
Compound 26f (530 mg, 1.3 mmol) was dissolved in dimethylacetamide (5.3 ml) and triethylamine (0.236 ml, 1.7 mmol) was added. The reaction solution was cooled to −20 ° C., methanesulfonyl chloride (0.117 ml, 1.5 mmol) was added, and the mixture was stirred at the same temperature for 20 minutes. This solution is defined as a mixed acid anhydride solution of compound 26f.
Meanwhile, phosphorus pentachloride (312 mg, 1.5 mmol) was suspended in methylene chloride (5.3 ml), and pyridine (0.137 ml, 1.7 mmol) was added at 0 ° C. Compound 26e (535 mg, 1 mmol) was added to the reaction solution, and the mixture was stirred at 0 ° C. for 20 minutes. The reaction was then cooled to −50 ° C. and methanol (2.7 ml) was added. The reaction mixture was stirred at 0 ° C. for 40 minutes, sodium bicarbonate water was added, and the methylene chloride layer was separated. The methylene chloride layer was dried over magnesium sulfate, and then a mixed acid anhydride solution of the above compound 26f was added at 0 ° C. The reaction solution was stirred at 0 ° C. for 30 minutes, ethyl acetate and water were added, and the mixture was concentrated under reduced pressure to remove methylene chloride. The organic layer was separated, washed with water and saturated brine in that order, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain 26 g (781 mg, 97% yield) of the compound.
¹ H-NMR (CDCl ₃ ) δ: 1.53 (9H, s), 3.49, 3.59 (2H, ABq, J = 17.6 Hz), 3.77 (3H, s), 5.16 (1H, d, J = 4.8 Hz), 5.20-5.27 (3H, m), 5.42 (1H, d, J = 17.4 Hz), 5.95 (1H, dd, J = 9.0, 4.9 Hz), 6.81-7.39 (25H, m).

Step 7:
Compound 26g (0.761 g, 0.944 mmol) was dissolved in methylene chloride (7.6 mL) and anisole (722 μL, 6.61 mmol) was added. The reaction mixture was then cooled to −30 ° C., 2 mol / L-aluminum chloride / nitromethane solution (3.31 mL, 6.61 mmol) was added, and the mixture was stirred at 0 ° C. for 1 hr. Isopropyl ether and 2N aqueous hydrochloric acid (3 ml) were added to the reaction solution to precipitate an oily insoluble material, and the supernatant was removed by decantation. Dilute hydrochloric acid and acetonitrile were added to the resulting residue and dissolved. HP-20SS was added to the resulting solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to obtain Compound I-26 (60 mg, 15% yield).
¹ H-NMR (DMSO-D ₆ ) δ: 3.59, 3.92 (2H, ABq, J = 17.6 Hz), 5.26 (1H, d, J = 11.2 Hz), 5.34 (1H, d, J = 4.8 Hz), 5.58 (1H, d, J = 17.3 Hz), 5.73 (1H, dd, J = 7.8, 4.9 Hz), 6.61 (1H, s), 6.68 (1H, dd, J = 17.3, 11.2 Hz), 7.07 (2H , s), 9.50 (1H, d, J = 8.2 Hz).

(Example 27)
Synthesis of Compound I-27 (4-position tetrazole of cefixime)

Step 1:
Phosphorus pentachloride (312 mg, 1.5 mmol) was suspended in methylene chloride (5.3 ml), and pyridine (0.137 ml, 1.7 mmol) was added at 0 ° C. Compound 26e (535 mg, 1 mmol) was added to the reaction solution, and the mixture was stirred at 0 ° C. for 20 minutes. The reaction was then cooled to −50 ° C. and methanol (2.7 ml) was added. The reaction mixture was stirred at 0 ° C. for 40 minutes, sodium bicarbonate water was added, and the methylene chloride layer was separated. The methylene chloride layer was dried over magnesium sulfate, and dimethylformamide (5.3 ml) and compound 27a (882 mg, 1.7 mmol) were added. The reaction solution was concentrated under reduced pressure to remove methylene chloride, and N-methylmorpholine (165 μl, 1.5 mmol) was added. The reaction solution was stirred at 60 ° C. for 1.5 hours and then allowed to stand at room temperature for 4 days. Dilute hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was removed under reduced pressure to give compound 27b (618 mg, 77% yield).
¹ H-NMR (CDCl ₃ ) δ: 1.39 (9H, s), 1.54 (9H, s), 3.58, 3.75 (2H, ABq, J = 17.4 Hz), 4.69-4.79 (2H, m), 5.23-5.27 (2H, m), 5.43 (1H, d, J = 17.4 Hz), 5.97 (1H, dd, J = 8.5, 4.9 Hz), 6.89 (1H, dd, J = 17.4, 11.0 Hz), 7.26-7.39 ( 13H, m), 5.40 (1H, br s), 8.70 (1H, d, J = 8.5 Hz).

Step 2:
Compound 27b (0.607 g, 0.759 mmol) was dissolved in methylene chloride (6 mL) and anisole (829 μL, 7.59 mmol) was added. The reaction mixture was then cooled to −30 ° C., 2 mol / L-aluminum chloride / nitromethane solution (3.79 mL, 7.59 mmol) was added, and the mixture was stirred at 0 ° C. for 1 hr. The reaction mixture was extracted with isopropyl ether, dilute hydrochloric acid, acetonitrile, and tetrahydrofuran. The organic layer was extracted in the order of water and sodium bicarbonate water, and all aqueous layers were collected. HP-20SS was added to the obtained aqueous solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to give compound I-27 (228 mg, yield 63%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.62, 3.93 (2H, dd, J = 17.6 Hz), 4.53 (2H, s), 5.27 (1H, d, J = 11.3 Hz), 5.36 (1H, d , J = 4.8 Hz), 5.59 (1H, d, J = 17.3 Hz), 5.75 (1H, dd, J = 8.0, 4.9 Hz), 6.67 (1H, dd, J = 17.3, 11.2 Hz), 6.75 (1H , s), 7.20 (2H, s), 9.58 (1H, d, J = 8.2 Hz).

(Example 28)
Synthesis of Compound I-28 (Cefpodoxime 4-position tetrazole)

Step 1:
Compound 28a (722 mg, 1.0 mmol) was dissolved in methanol (7 mL), sodium bicarbonate (252 mg, 3 mmol) was added, and the mixture was stirred at room temperature for 1 day. Next, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 28b (702 mg, yield 98%).
¹ H-NMR (CDCl ₃ ) δ: 1.54 (9H, s), 3.14 (3H, s), 3.78, 3.83 (2H, ABq, J = 12.2 Hz), 4.09 (3H, s), 5.42 (1H, d , J = 4.0 Hz), 5.81 (1H, dd, J = 8.8, 4.0 Hz), 5.87 (1H, s), 6.34 (1H, s), 7.28-7.36 (19H, m), 8.43 (1H, s) .

Step 2:
Compound 28b (689 mg, 0.96 mmol) was dissolved in methylene chloride (4 mL), and a solution of 65% -m-chloroperbenzoic acid (268 mg, 1 mmol) in methylene chloride (3 ml) was added at -70 ° C. The reaction solution was stirred at −70 ° C. for 20 minutes, and further stirred at −30 ° C. for 30 minutes. Sodium thiosulfate (76 mg, 0.48 mmol), aqueous sodium bicarbonate, and ethyl acetate were added to the reaction solution, and the mixture was concentrated under reduced pressure to remove methylene chloride. Next, the organic layer was separated, washed twice with aqueous sodium bicarbonate, then with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography, eluting with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 28c (505 mg, yield 72%).
¹ H-NMR (CDCl ₃ ) δ: 1.53 (9H, s), 3.25 (3H, d, J = 6.4 Hz), 3.29, 4.03 (2H, Abq. J = 12.0 Hz), 4.08 (3H, s), 4.23, 4.47 (2H, ABq, J = 13.2 Hz), 4.72 (1H, dd, J = 4.8, 1.4 Hz), 6.25 (1H, dd, J = 10.0, 4.8 Hz), 7.26-7.41 (12H, m) , 7.83 (1H, d, J = 10.0 Hz), 8.56 (1H, s).

Step 3:
Compound 28c (0.496 g, 0.676 mmol) was dissolved in methylene chloride (5 mL), and phosphorus tribromide (127 μl, 1.35 mmol) was added at −50 ° C. The reaction solution was stirred at −40 ° C. for 30 minutes. Anisole (738 μL, 6.76 mmol), 2 mol / L-aluminum chloride / nitromethane solution (2.7 mL, 5.41 mmol) were sequentially added to the reaction solution, and the mixture was stirred at 0 ° C. for 1 hour. The reaction solution was extracted by adding isopropyl ether, dilute hydrochloric acid and acetonitrile. The organic layer was extracted in the order of water and sodium bicarbonate water, and all aqueous layers were collected. HP-20SS was added to the obtained aqueous solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to obtain Compound I-28 (241 mg, yield 79%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.18 (3H, s), 3.63, 3.70 (2H, Abq. J = 17.8 Hz), 3.84 (3H, s), 4.13 (2H, s), 5.38 (1H , d, J = 4.8 Hz), 5.77 (1H, dd, J = 8.1, 5.1 Hz), 6.75 (1H, s), 7.22 (2H, s), 9.68 (1H, d, J = 8.1 Hz).

(Example 29)
Synthesis of Compound I-29 (Cethotium 4-position tetrazole)

Step 1:
Compound 29a (1.75 g, 6.0 mmol) was dissolved in dimethylacetamide (17 mL) and triethylamine (1.04 ml, 7.5 mmol) was added. Methanesulfonyl chloride (0.545 ml, 7 mmol) was added to the mixture at −20 ° C., and the mixture was stirred at the same temperature for 20 minutes. Next, 2,6-lutidine (1.46 ml, 12.5 mmol) and compound 29b (2.38 g, 5 mmol) were sequentially added to the reaction solution, followed by stirring at 0 ° C. for 30 minutes. Dilute hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain compound 29c (1.35 g, yield 38%).
¹ H-NMR (CDCl ₃ ) δ: 3.58, 3.52 (2H, ABq, J = 16.2 Hz), 4.04, 4.07 (2H, ABq, J = 12.6, Hz), 5.21 (1H, d, J = 3.8 Hz) , 5.28 (2H, s), 5.56 (1H, dd, J = 8.1, 4.0 Hz), 5.92 (1H, s), 6.33 (1H, s), 6.67 (1H, s), 7.24-7.52 (17H, m ).

Step 2:
Compound 29c (1.3 g, 1.82 mmol) was dissolved in methylene chloride (7 mL), and a solution of 65% -m-chloroperbenzoic acid (508 mg, 1.91 mmol) in methylene chloride (6 ml) at −50 ° C. added. The reaction solution was stirred at −50 ° C. for 30 minutes. Sodium thiosulfate (144 mg, 0.91 mmol), aqueous sodium bicarbonate, and ethyl acetate were added to the reaction solution, and the mixture was concentrated under reduced pressure to remove methylene chloride. Next, the organic layer was separated, washed twice with aqueous sodium bicarbonate, then with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 29d (1.0 g, yield 75%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.63, 3.66 (2H, ABq, J = 15.8 Hz), 3.77, 4.02 (2H, ABq, J = 18.6 Hz), 4.50, 4.67 (2H, ABq, J = 11.6 Hz), 5.11 (1H, d, J = 4.4 Hz), 5.22 (2H, s), 5.97 (1H, dd, J = 8.7, 4.9 Hz), 6.95 (1H, s), 7.32-7.43 (16H, m), 7.83 (1H, s), 8.21 (1H, d, J = 8.7 Hz).

Step 3:
Compound 29d (957 mg, 1.31 mmol) was dissolved in dimethylformamide (10 mL), and sodium iodide (393 mg, 2.62 mmol) was added at 0 ° C. The reaction solution was stirred at 0 ° C. for 1 hour, and then compound 29e (273 mg, 1.58 mmol) and potassium carbonate (200 mg, 1.44 mmol) were sequentially added. The reaction solution was stirred at 0 ° C. for 3 hours and then allowed to stand overnight in a 5 ° C. refrigerator. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and then with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain Compound 29f (1.10 g, yield 97%).
¹ H-NMR (CDCl ₃ ) δ: 2.18 (6H, d, J = 16.9 Hz), 2.50-2.69 (2H, m), 3.51, 3.60 (2H, ABq, J = 16.4 Hz), 3.41, 4.05 (2H , ABq, J = 18.4 Hz), 4.09-4.43 (4H, m), 4.52 (1H, d, J = 4.5 Hz), 5.23 (2H, dd, J = 30.1, 11.9 Hz), 6.07 (1H, dd, J = 10.4, 4.8 Hz), 6.64 (1H, s), 7.23-7.37 (16H, m, J = 22.1, 8.1 Hz), 8.41 (1H, d, J = 10.1 Hz).

Step 4:
Compound 29f (1.09 g, 1.26 mmol) was dissolved in methylene chloride (10 mL), and phosphorus tribromide (237 μl, 2.52 mmol) was added at −50 ° C. The reaction solution was stirred at −40 ° C. for 30 minutes. Next, anisole (1.38 mL, 12.59 mmol), 2 mol / L-aluminum chloride / nitromethane solution (5.04 mL, 10.07 mmol) were sequentially added to the reaction solution, and the mixture was stirred at 0 ° C. for 1 hour. A 2 mol / L-aluminum chloride / nitromethane solution (3.78 mL, 7.56 mmol) was added to the reaction solution twice, and the mixture was further stirred at 0 ° C. for 2 hours. Isopropyl ether, dilute hydrochloric acid and acetonitrile were added to the reaction solution, and the aqueous layer was separated. HP-20SS was added to the obtained aqueous solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound were collected by elution with 0.002 M / L sulfuric acid aqueous solution-acetonitrile, and after concentration, the pyridine polymer was added with stirring to adjust the pH to 3.3. The pyridine polymer was filtered, and the filtrate was freeze-dried to obtain Compound I-29 (294 mg, yield 36%).
¹ H-NMR (DMSO-D ₆ ) δ: 2.50 (6H, s), 3.40 (2H, s), 3.48 (2H, t, J = 6.1 Hz), 3.75, 3.83 (2H, ABq, J = 18.0 Hz ), 4.25, 4.47 (2H, ABq, J = 13.4 Hz), 4.66 (2H, dd, J = 10.4, 6.1 Hz), 5.25 (1H, d, J = 5.1 Hz), 5.69 (1H, dd, J = 8.2, 4.9 Hz), 6.27 (1H, s), 6.97 (2H, s), 8.92 (1H, d, J = 8.3 Hz).

(Example 30)
Synthesis of Compound I-30 (4-position tetrazole of cefteram)

Step 1:
Compound 30a (738 mg, 1.0 mmol) was dissolved in dimethylformamide (3.7 mL), sodium iodide (300 mg, 2.0 mmol) was added at 15 ° C., and the mixture was stirred at the same temperature for 30 min. Compound 30b (109 mg, 1.30 mmol) and then potassium carbonate (166 mg, 1.2 mmol) were added to the reaction solution at −30 ° C. The reaction solution was stirred at −30 ° C. for 1 hour and then stirred at 0 ° C. for 4 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 30c (277 g, yield 35%).
¹ H-NMR (DMSO-D ₆ ) δ: 1.47 (9H, s), 2.30 (3H, s), 3.46, 3.91 (2H, ABq, J = 17.2 Hz), 3.89 (3H, s), 5.13 (1H , d, J = 3.8 Hz), 5.28, 5.49 (2H, ABq, J = 15.6 Hz), 5.98 (1H, t, J = 6.2 Hz), 7.37 (11H, dt, J = 33.6, 7.2 Hz), 7.86 (1H, s), 9.23 (1H, d, J = 7.7 Hz).

Step 2:
Compound I-30 (88 mg, 52% yield) was obtained by treating in the same manner as in Step 3 of Example 28 using Compound 30c (266 mg, 0.34 mmol).
¹ H-NMR (DMSO-D ₆ ) δ: 3.50, 5.57 (2H, ABq, J = 18.0 Hz), 3.84 (3H, s), 5.32, 5.39 (2H, ABq, J = 15.2 Hz), 5.40 (1H , d, J = 5.0 Hz), 5.82 (1H, dd, J = 8.2, 4.9 Hz), 6.75 (1H, s), 7.25 (2H, s), 9.72 (1H, d, J = 8.2 Hz).

(Example 31)
Synthesis of compound I-31 (4-position tetrazole of cefetameth)

Step 1:
Compound 31a (10.71 g, 50 mmol) was suspended in water (54 mL), and sodium bicarbonate (10.50 g, 125 mmol) and 1,4-dioxane (54 mL) were sequentially added at 0 ° C. The mixture was stirred and dissolved at 0 ° C. for 1 hour, and then allyl chloroformate (6.4 mL, 60 mmol) was added. After stirring the reaction solution at 0 ° C. for 40 minutes, ethyl acetate and dilute hydrochloric acid were added to confirm that the pH was 2 or less, and the organic layer was separated. The organic layer was washed with water and saturated brine in that order and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. Ethyl acetate and a 5% aqueous sodium bicarbonate solution (100 mL) were added to the resulting residue, and the aqueous layer was separated. After adding ethyl acetate to the obtained aqueous layer, the pH was adjusted to 2 or less with concentrated hydrochloric acid, and the organic layer was separated. The organic layer was washed with water and saturated brine in that order, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give compound 31b (10.42 g, yield 70%).
¹ H-NMR (DMSO-D ₆ ) δ: 2.02 (3H, s), 3.37, 3.53 (2H, ABq, J = 18.0 Hz), 4.53 (2H, d, J = 5.1 Hz), 5.03 (1H, d , J = 4.5 Hz), 5.20 (1H, d, J = 10.6 Hz), 5.31 (1H, d, J = 17.2 Hz), 5.41 (1H, dd, J = 8.6, 4.5 Hz), 5.89-5.96 (1H , m), 8.36 (1H, d, J = 8.6 Hz).

Step 2:
Compound 31b (9.56 g, 32 mmol) was suspended in methylene chloride (96 mL), and 1-chloroN, N, 2-trimethyl-1-propenylamine (5.09 mL, 38.5 mmol) was added at 0 ° C. It was. The reaction was stirred at 0 ° C. for 30 minutes and then cooled to −60 ° C., after which 4-methoxybenzylamine (10.47 mL, 80 mmol) in methylene chloride (20 ml) was added. The reaction solution was stirred at −60 ° C. for 20 minutes, ethyl acetate and dilute hydrochloric acid were added, and the mixture was concentrated under reduced pressure to remove methylene chloride. Since the mixed solution gelled, tetrahydrofuran was added and dissolved, and then the organic layer was separated. The organic layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give compound 31c (13.66 g, yield 102%).
¹ H-NMR (DMSO-D ₆ ) δ: 1.98 (3H, s), 3.31, 3.39 (2H, ABq, J = 17.4 Hz), 3.72 (3H, s), 4.26-4.32 (2H, m), 4.54 (2H, d, J = 5.1 Hz), 4.96 (1H, d, J = 4.5 Hz), 5.20 (1H, d, J = 10.6 Hz), 5.30-5.32 (2H, m), 5.89-5.95 (1H, m), 6.86 (2H, d, J = 8.6 Hz), 7.23 (2H, d, J = 8.6 Hz), 8.38 (1H, d, J = 9.1 Hz), 8.59 (1H, t, J = 10.0 Hz) .

Step 3:
Compound 31c (4.17 g, 10 mmol) was dissolved in methylene chloride (42 mL), triphosgene (1.48 g, 5.0 mmol) was added at 0 ° C., and pyridine (2.83 mL, 35 mmol) was added dropwise. The reaction solution was stirred at 0 ° C. for 30 minutes, and then trimethylsilyl azide (3.97 mL, 30 mmol) and methanol (1.01 mL, 25 mmol) were sequentially added. The reaction solution was stirred at 0 ° C. overnight, and the solvent was distilled off under reduced pressure. Dilute hydrochloric acid was added to the residue and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography, eluting with hexane-ethyl acetate. Fractions containing the desired compound were collected, and the solvent was distilled off under reduced pressure to obtain compound 31d (4.24 g, yield 96%).
¹ H-NMR (DMSO-D ₆ ) δ: 1.37 (3H, s), 3.40, 3.58 (2H, ABq, J = 18.0 Hz), 3.74 (4H, s), 4.54 (2H, d, J = 5.3 Hz ), 5.19-5.23 (2H, m), 5.31 (1H, dd, J = 17.3, 1.6 Hz), 5.53-5.59 (3H, m), 5.89-5.95 (1H, m), 6.92 (2H, d, J = 9.4 Hz), 7.23 (2H, d, J = 8.7 Hz), 8.45 (1H, d, J = 8.9 Hz).

Step 4:
Compound 31d (4.09 g, 9.24 mmol) was dissolved in methylene chloride (41 mL) and dimedone (3.89 g, 27.7 mmol) was added followed by tetrakis (triphenylphosphine) palladium (534 mg, 0.462 mmol). . The reaction solution was stirred overnight at room temperature, and then the solvent was concentrated under reduced pressure. Sodium bicarbonate water was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography, eluting with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 31e (2.88 g, yield 87%).
¹ H-NMR (CDCl ₃ ) δ: 1.64 (3H, s), 3.13, 3.49 (2H, ABq, J = 18.0 Hz), 3.79, (3H, s), 4.68 (1H, br s), 4.97 (1H , d, J = 5.1 Hz), 5.53 (2H, s), 6.86 (2H, d, J = 8.6 Hz), 7.18 (2H, d, J = 8.6 Hz).

Step 5:
Compound 31f (362 mg, 1.2 mmol) was dissolved in dimethylacetamide (4 mL) and triethylamine (0.208 mL, 1.5 mmol) was added. The mixture was cooled to −20 ° C. and methanesulfonyl chloride (0.109 mL, 1.4 mmol) was added. The reaction solution was stirred at −20 ° C. for 20 minutes, and then N-methylmorpholine (0.132 mL, 1.2 mmol) and then compound 31e (358 mg, 1 mmol)) were added. The reaction mixture was stirred at 0 ° C. for 30 minutes, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography, eluting with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 31g (449 mg, yield 70%).
¹ H-NMR (CDCl ₃ ) δ: 1.42 (3H, s), 1.53 (9H, s), 3.17, 3.51 (2H, ABq, J = 24.2 Hz), 3.78 (3H, s), 4.08 (3H, s ), 5.06 (1H, d, J = 4.8 Hz), 5.47, 5.55 (2H, ABq, J = 15.0 Hz), 5.87 (1H, dd, J = 8.8, 4.8 Hz), 6.85 (2H, d, J = 8.6 Hz), 7.15 (2H, d, J = 8.6 Hz), 7.26 (1H, s), 7.33 (1H, d, J = 8.6 Hz), 8.49 (1H, s).

Step 6:
Compound 31g (433 mg, 0.63 mmol) was dissolved in methylene chloride (4.3 mL) and anisole (0.688 mL, 6.3 mmol) was added. The reaction mixture was then cooled to −30 ° C., 2 mol / L-aluminum chloride / nitromethane solution (2.52 mL, 5.04 mmol) was added, and the mixture was stirred at 0 ° C. for 30 min. The reaction solution was extracted by adding isopropyl ether, dilute hydrochloric acid, and acetonitrile. The organic layer was extracted in the order of water and sodium bicarbonate water, and all aqueous layers were collected. HP-20SS was added to the obtained aqueous solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to obtain Compound I-31 (125 mg, yield 47%).
¹ H-NMR (DMSO-D ₆ ) δ: 1.94 (3H, s), 3.45, 3.61 (2H, ABq, J = 18.8 Hz), 3.77 (3H, s), 5.25 (1H, d, J = 4.8 Hz ), 5.65 (1H, dd, J = 8.2, 4.6 Hz), 6.69 (1H, s), 7.16 (2H, s), 9.61 (1H, d, J = 8.2 Hz).

(Example 32)
Synthesis of Compound I-32 (4-position tetrazole of ceftibutene)

Step 1:
Compound 32a (21.99 g, 60 mmol) was suspended in tetrahydrofuran (220 mL), pyridine (7.26 mL, 90 mmol) was added, and then allyl chloroformate (7.68 mL, 72 mmol) was added at 0 ° C. Since a gum-like insoluble material was precipitated from the reaction solution, the temperature was raised to room temperature, methylene chloride (220 mL) was added, and pyridine (2.4 mL, 30 mmol and allyl chloroformate (1.92 mL, 18 mmol) were added twice. After stirring the reaction solution at room temperature for 1 hour, ethyl acetate and dilute hydrochloric acid were added to confirm that the pH was 2 or less, and methylene chloride was removed by concentration under reduced pressure. The organic layer was washed successively with water and saturated brine and dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain compound 32b (26.65 g, yield 99%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.60-3.69 (2H, m), 4.54 (2H, d, J = 5.1 Hz), 5.09 (1H, d, J = 5.1 Hz), 5.20 (1H, dd , J = 10.5, 0.9 Hz), 5.31 (1H, dd, J = 17.2, 1.5 Hz), 5.64 (1H, dd, J = 8.8, 5.1 Hz), 5.89-5.95 (1H, m), 6.76 (1H, dd, J = 6.2, 2.7 Hz), 6.91 (1H, s), 7.32-7.49 (10H, m), 8.44 (1H, d, J = 9.1 Hz).

Step 2:
Compound 32b (26.55 g, 58.9 mmol) was dissolved in methylene chloride (266 mL), anisole (25.7 mL, 236 mmol) was added, and the mixture was cooled to −30 ° C. 118 mL, 236 mmol) was added. The reaction solution was stirred at −20 ° C. for 30 minutes, and then ethyl acetate and dilute hydrochloric acid were added. The mixture was concentrated under reduced pressure to remove methylene chloride, and the organic layer was separated. The organic layer was washed with water, an aqueous sodium bicarbonate solution (100 mL) was added, the pH was adjusted to 7 or more, and the aqueous layer was separated. After adding ethyl acetate to the obtained aqueous layer, the pH was adjusted to 2 or less with concentrated hydrochloric acid, and the organic layer was separated. The organic layer was washed in turn with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give compound 32c (14.81 g, yield 88%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.53-3.62 (2H, m), 4.53 (2H, d, J = 5.3 Hz), 5.04 (1H, d, J = 4.9 Hz), 5.20 (1H, dd , J = 10.5, 1.5 Hz), 5.31 (1H, dd, J = 17.3, 1.7 Hz), 5.56 (1H, dd, J = 8.8, 5.0 Hz), 5.87-5.96 (1H, m), 6.47 (1H, dd, J = 6.1, 2.6 Hz), 8.41 (1H, d, J = 8.9 Hz).

Step 3:
Compound 32c (14.7 g, 51.7 mmol) was suspended in methylene chloride (147 mL) and 1-chloroN, N, 2-trimethyl-1-propenylamine (8.21 mL, 62.1 mmol) was suspended at 0 ° C. Was added. The reaction solution was stirred at 0 ° C. for 30 minutes and then cooled to −60 ° C., and then a solution of 4-methoxybenzylamine (16.9 mL, 129 mmol) in methylene chloride (30 ml) was added. The reaction solution was stirred at −60 ° C. for 20 minutes and then concentrated under reduced pressure to remove methylene chloride. Ethyl acetate and water were added to the residue, and the precipitated solid was collected by filtration. The obtained solid was air-dried to obtain Compound 32d (19.24 g, yield 92%).
¹ H-NMR (DMSO-D ₆ ) δ: 3.49-3.60 (2H, m), 3.72 (3H, s), 4.32 (2H, d, J = 5.9 Hz), 4.54 (2H, d, J = 5.4 Hz ), 5.05 (1H, d, J = 4.9 Hz), 5.20 (1H, dd, J = 10.5, 1.6 Hz), 5.31 (1H, dd, J = 17.3, 1.7 Hz), 5.48 (1H, dd, J = 8.9, 4.9 Hz), 5.87-5.97 (1H, m), 6.25 (1H, dd, J = 6.1, 2.6 Hz), 6.87 (2H, d, J = 8.7 Hz), 7.23 (2H, d, J = 8.7 Hz), 8.44 (1H, d, J = 9.0 Hz), 8.61 (1H, t, J = 5.9 Hz).

Step 4:
Compound 32e (1.41 g, 33% yield) was obtained by treating in the same manner as in Step 3 of Example 31 using Compound 32d (4.03 g, 10 mmol).
¹ H-NMR (CDCl ₃ ) δ: 3.38-3.53 (2H, m), 3.80 (3H, s), 4.63 (2H, d, J = 5.6 Hz), 4.94 (1H, d, J = 5.1 Hz), 5.27 (1H, d, J = 10.4 Hz), 5.34 (1H, d, J = 17.2 Hz), 5.47-5.68 (4H, m), 5.89-5.94 (2H, m), 6.87 (2H, d, J = 8.6 Hz), 7.07 (2H, d, J = 8.3 Hz).

Step 5:
Compound 32f (0.91 g, 81% yield) was obtained by treating in the same manner as in Step 4 of Example 31 using Compound 32e (1.40 g, 3.27 mmol).
¹ H-NMR (CDCl ₃ ) δ: 1.81 (2H, s), 3.36-3.53 (2H, m), 3.79 (3H, s), 4.81 (1H, d, J = 1.3 Hz), 4.95 (1H, d , J = 5.1 Hz), 5.47, 5.62 (2H, dd, J = 15.2 Hz), 5.84 (1H, dd, J = 6.6, 2.3 Hz), 6.86 (2H, d, J = 8.6 Hz), 7.08 (2H , d, J = 8.6 Hz).

Step 6:
Compound 32f (0.86 g, 2.50 mmol) and compound 32 g (1.51 g, 3.50 mmol, cis / trans = about 2/1, see CN85101417 for the synthesis method) dissolved in methylene chloride (8.6 mL) 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.67 g, 3.50 mmol) was added at 0 ° C. The reaction solution was stirred at room temperature for 30 minutes, and then the solvent was distilled off under reduced pressure. Water was added to the residue and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate. Fractions containing the desired compound were collected and the solvent was distilled off under reduced pressure to obtain Compound 32h (1.77 g, 94% yield) as a mixture of cis / trans = 3/2 at the side chain site.
The obtained compound 32h (1.69 g, 2.11 mmol) was dissolved in methylene chloride (16.9 mL), and anisole (2.30 mL, 6.3 mmol) was added. The reaction mixture was then cooled to −30 ° C., 2 mol / L-4 titanium chloride / methylene chloride solution (7.37 mL, 14.7 mmol) was added, and the mixture was stirred at room temperature for 30 min. The reaction solution was extracted by adding isopropyl ether, dilute hydrochloric acid, and acetonitrile. The organic layer was extracted in the order of water and sodium bicarbonate water, and all aqueous layers were collected. HP-20SS was added to the obtained aqueous solution, concentrated under reduced pressure, and then subjected to HP20SS column chromatography. Fractions containing the desired compound eluted with water-acetonitrile were collected, concentrated, and lyophilized to obtain a compound of I-32 (417 mg, yield 46%) as a mixture of cis / trans = 1/1 at the side chain site. Got.
¹ H-NMR (DMSO-D ₆ ) δ: 3.17 (1H, d, J = 7.4 Hz), 3.39 (1H, dd, J = 7.2, 1.6 Hz), 3.55-3.67 (2H, m), 5.30 (0.5 H, d, J = 5.0 Hz), 5.33 (0.5H, d, J = 5.0 Hz), 5.80-5.85 (1H, m), 6.24 (0.5H, s), 6.30-6.34 (1H, m), 6.44 (0.5H, t, J = 7.4 Hz), 6.54 (0.5H, s), 6.62 (0.5H, t, J = 7.3 Hz), 7.01 (1H, s), 7.12 (1H, s), 9.29 (0.5 H, d, J = 8.5 Hz), 9.37 (0.5H, d, J = 7.9 Hz).

The present invention also includes the compounds shown below and pharmaceutically acceptable salts.

Furthermore, the present invention provides the following formulas (IA) and (IB):

In the above, Ra, Rb, Rc, Rd and Re are selected from Ra1 to Ra27, Rb1 to Rb2, (Rc1 to Rc5, Rcc1, Rcc2), (Rd1 to Rd29, Rdd1 to Rdd8) and Re1 to Re13 shown below Also included are compounds that are combinations.
Here, the bonding mode of the double bond between the carbon atoms in Rc may be any of a cis bond, a trans bond, or a mixture thereof.

Examples of Ra:

(In the formula, Me represents methyl.)

(In the formula, Me represents methyl.)

Rb example:
-S-: Rb1
-O-: Rb2
Rc example:

Rd example:

(In the formula, Me represents methyl, Et represents ethyl, and Ph represents phenyl.)
Here, in Rd1, Rd4, Rd5, Rd9, Rd12, and Rd16 to Rd23, any carbon atom that can be bonded on the ring can bond to Rc. For example, Rd1 is represented by the following formula:

The group shown by these is included.

Re example:

(In the formula, Me represents methyl and Ph represents phenyl.)

In the compound represented by the formula (IA), combinations of Ra, Rb, Rc and Rd include the following.
(Ra, Rb, Rc, Rd) = (Ra1, Rb1, Rc1, Rd1), (Ra1, Rb1, Rc1, Rd2), (Ra1, Rb1, Rc1, Rd3), (Ra1, Rb1, Rc1, Rd4), (Ra1, Rb1, Rc1, Rd5), (Ra1, Rb1, Rc1, Rd6), (Ra1, Rb1, Rc1, Rd7), (Ra1, Rb1, Rc1, Rd8), (Ra1, Rb1, Rc1, Rd9), (Ra1, Rb1, Rc1, Rd10), (Ra1, Rb1, Rc1, Rd11), (Ra1, Rb1, Rc1, Rd12), (Ra1, Rb1, Rc1, Rd13), (Ra1, Rb1, Rc1, Rd14), (Ra1, Rb1, Rc1, Rd15), (Ra1, Rb1, Rc1, Rd16), (Ra1, Rb1, Rc1, Rd17), (Ra1, Rb1, Rc1, Rd18), (Ra1, Rb1, Rc1, Rd19), (Ra1, Rb1, Rc1, Rd20), (Ra1, Rb1, Rc1, Rd21), (Ra1, Rb1, Rc1, Rd22), (Ra1, Rb1, Rc1, Rd23), (Ra1, Rb1, Rc1, Rd24), (Ra1, Rb1, Rc1, Rd25), (Ra1, Rb1, Rc1, Rd26), (Ra1, Rb1, Rc1, Rd27), (Ra1, Rb1, Rc1, Rd28), (Ra1, Rb1, Rc1, Rd29), (Ra1, Rb1, Rc2, Rd1), (Ra1, Rb1, Rc2, Rd2), (Ra1, Rb1, Rc2, Rd3), (Ra1, Rb1, Rc2, Rd4), (Ra1, Rb1, Rc2, Rd5), (Ra1, Rb1, Rc2, Rd6), (Ra1, Rb1, Rc2, Rd7), (Ra1, Rb1, Rc2, Rd8), (Ra1, Rb1, Rc2, Rd9), (Ra1, Rb1, Rc2, Rd10), (Ra1, Rb1, Rc2, Rd11), (Ra1, Rb1, Rc2, Rd12), (Ra1, Rb1, Rc2, Rd13), (Ra1, Rb1, Rc2, Rd14), (Ra1, Rb1, Rc2, Rd15), (Ra1, Rb1, Rc2, Rd16), (Ra1, Rb1, Rc2, Rd17), (Ra1, Rb1, Rc2, Rd18), (Ra1, Rb1, Rc2, Rd19), (Ra1, Rb1, Rc2, Rd20), (Ra1, Rb1, Rc2, Rd21), (Ra1, Rb1, Rc2, Rd22), (Ra1, Rb1, Rc2, Rd23), (Ra1, Rb1, Rc2, Rd24), (Ra1, Rb1, Rc2, Rd25), (Ra1, Rb1, Rc2, Rd26), (Ra1, Rb1, Rc2, Rd27), (Ra1, Rb1, Rc2, Rd28), (Ra1, Rb1, Rc2, Rd29), (Ra1, Rb1, Rc3, Rd1), (Ra1, Rb1, Rc3, Rd2), (Ra1, Rb1, Rc3, Rd3), (Ra1, Rb1, Rc3, Rd4), (Ra1, Rb1, Rc3, Rd5), (Ra1, Rb1, Rc3, Rd6), (Ra1, Rb1, Rc3, Rd7), (Ra1, Rb1, Rc3, Rd8), (Ra1, Rb1, Rc3, Rd9), (Ra1, Rb1, Rc3, Rd10), (Ra1, Rb1, Rc3, Rd11), (Ra1, Rb1, Rc3, Rd12), (Ra1, Rb1, Rc3, Rd13), (Ra1, Rb1, Rc3, Rd14), (Ra1, Rb1, Rc3, Rd15), (Ra1, Rb1, Rc3, Rd16), (Ra1, Rb1, Rc3, Rd17), (Ra1, Rb1, Rc3, Rd18), (Ra1, Rb1, Rc3, Rd19), (Ra1, Rb1, Rc3, Rd20), (Ra1, Rb1, Rc3, Rd21), (Ra1, Rb1, Rc3, Rd22), (Ra1, Rb1, Rc3, Rd23), (Ra1, Rb1, Rc3, Rd24), (Ra1, Rb1, Rc3, R d25), (Ra1, Rb1, Rc3, Rd26), (Ra1, Rb1, Rc3, Rd27), (Ra1, Rb1, Rc3, Rd28), (Ra1, Rb1, Rc3, Rd29), (Ra1, Rb1, Rc4, Rd1), (Ra1, Rb1, Rc4, Rd2), (Ra1, Rb1, Rc4, Rd3), (Ra1, Rb1, Rc4, Rd4), (Ra1, Rb1, Rc4, Rd5), (Ra1, Rb1, Rc4, Rd6), (Ra1, Rb1, Rc4, Rd7), (Ra1, Rb1, Rc4, Rd8), (Ra1, Rb1, Rc4, Rd9), (Ra1, Rb1, Rc4, Rd10), (Ra1, Rb1, Rc4, Rd11), (Ra1, Rb1, Rc4, Rd12), (Ra1, Rb1, Rc4, Rd13), (Ra1, Rb1, Rc4, Rd14), (Ra1, Rb1, Rc4, Rd15), (Ra1, Rb1, Rc4, Rd16), (Ra1, Rb1, Rc4, Rd17), (Ra1, Rb1, Rc4, Rd18), (Ra1, Rb1, Rc4, Rd19), (Ra1, Rb1, Rc4, Rd20), (Ra1, Rb1, Rc4, Rd21), (Ra1, Rb1, Rc4, Rd22), (Ra1, Rb1, Rc4, Rd23), (Ra1, Rb1, Rc4, Rd24), (Ra1, Rb1, Rc4, Rd25), (Ra1, Rb1, Rc4, Rd26), (Ra1, Rb1, Rc4, Rd27), (Ra1, Rb1, Rc4, Rd28), (Ra1, Rb1, Rc4, Rd29), (Ra1, Rb1, Rc5, Rd1), (Ra1, Rb1, Rc5, Rd2), (Ra1, Rb1, Rc5, Rd3), (Ra1, Rb1, Rc5, Rd4), (Ra1, Rb1, Rc5, Rd5), (Ra1, Rb1, Rc5, Rd6), (Ra1, Rb1, Rc5, Rd7), (Ra1, Rb1, Rc5, Rd8), (Ra1, Rb1, Rc5, Rd9), (Ra 1, Rb1, Rc5, Rd10), (Ra1, Rb1, Rc5, Rd11), (Ra1, Rb1, Rc5, Rd12), (Ra1, Rb1, Rc5, Rd13), (Ra1, Rb1, Rc5, Rd14), ( (Ra1, Rb1, Rc5, Rd15), (Ra1, Rb1, Rc5, Rd16), (Ra1, Rb1, Rc5, Rd17), (Ra1, Rb1, Rc5, Rd18), (Ra1, Rb1, Rc5, Rd19), ( (Ra1, Rb1, Rc5, Rd20), (Ra1, Rb1, Rc5, Rd21), (Ra1, Rb1, Rc5, Rd22), (Ra1, Rb1, Rc5, Rd23), (Ra1, Rb1, Rc5, Rd24), ( (Ra1, Rb1, Rc5, Rd25), (Ra1, Rb1, Rc5, Rd26), (Ra1, Rb1, Rc5, Rd27), (Ra1, Rb1, Rc5, Rd28), (Ra1, Rb1, Rc5, Rd29), ( (Ra1, Rb2, Rc1, Rd1), (Ra1, Rb2, Rc1, Rd2), (Ra1, Rb2, Rc1, Rd3), (Ra1, Rb2, Rc1, Rd4), (Ra1, Rb2, Rc1, Rd5), ( (Ra1, Rb2, Rc1, Rd6), (Ra1, Rb2, Rc1, Rd7), (Ra1, Rb2, Rc1, Rd8), (Ra1, Rb2, Rc1, Rd9), (Ra1, Rb2, Rc1, Rd10), ( (Ra1, Rb2, Rc1, Rd11), (Ra1, Rb2, Rc1, Rd12), (Ra1, Rb2, Rc1, Rd13), (Ra1, Rb2, Rc1, Rd14), (Ra1, Rb2, Rc1, Rd15), ( (Ra1, Rb2, Rc1, Rd16), (Ra1, Rb2, Rc1, Rd17), (Ra1, Rb2, Rc1, Rd18), (Ra1, Rb2, Rc1, Rd19), (Ra1, Rb2, Rc1, Rd20), ( Ra1, Rb2, Rc1, Rd21), (Ra1, Rb2, Rc1, Rd22), (Ra1 , Rb2, Rc1, Rd23), (Ra1, Rb2, Rc1, Rd24), (Ra1, Rb2, Rc1, Rd25), (Ra1, Rb2, Rc1, Rd26), (Ra1, Rb2, Rc1, Rd27), (Ra1 , Rb2, Rc1, Rd28), (Ra1, Rb2, Rc1, Rd29), (Ra1, Rb2, Rc2, Rd1), (Ra1, Rb2, Rc2, Rd2), (Ra1, Rb2, Rc2, Rd3), (Ra1 , Rb2, Rc2, Rd4), (Ra1, Rb2, Rc2, Rd5), (Ra1, Rb2, Rc2, Rd6), (Ra1, Rb2, Rc2, Rd7), (Ra1, Rb2, Rc2, Rd8), (Ra1 , Rb2, Rc2, Rd9), (Ra1, Rb2, Rc2, Rd10), (Ra1, Rb2, Rc2, Rd11), (Ra1, Rb2, Rc2, Rd12), (Ra1, Rb2, Rc2, Rd13), (Ra1 , Rb2, Rc2, Rd14), (Ra1, Rb2, Rc2, Rd15), (Ra1, Rb2, Rc2, Rd16),

(Ra1, Rb2, Rc2, Rd17), (Ra1, Rb2, Rc2, Rd18), (Ra1, Rb2, Rc2, Rd19), (Ra1, Rb2, Rc2, Rd20), (Ra1, Rb2, Rc2, Rd21), (Ra1, Rb2, Rc2, Rd22), (Ra1, Rb2, Rc2, Rd24), (Ra1, Rb2, Rc2, Rd25), (Ra1, Rb2, Rc2, Rd26), (Ra1, Rb2, Rc2, Rd27), (Ra1, Rb2, Rc2, Rd28), (Ra1, Rb2, Rc2, Rd29), (Ra1, Rb2, Rc3, Rd1), (Ra1, Rb2, Rc3, Rd2), (Ra1, Rb2, Rc3, Rd3), (Ra1, Rb2, Rc3, Rd4), (Ra1, Rb2, Rc3, Rd5), (Ra1, Rb2, Rc3, Rd6), (Ra1, Rb2, Rc3, Rd7), (Ra1, Rb2, Rc3, Rd8), (Ra1, Rb2, Rc3, Rd9), (Ra1, Rb2, Rc3, Rd10), (Ra1, Rb2, Rc3, Rd11), (Ra1, Rb2, Rc3, Rd12), (Ra1, Rb2, Rc3, Rd13), (Ra1, Rb2, Rc3, Rd14), (Ra1, Rb2, Rc3, Rd15), (Ra1, Rb2, Rc3, Rd16), (Ra1, Rb2, Rc3, Rd17), (Ra1, Rb2, Rc3, 18Rd18), (Ra1, Rb2, Rc3, Rd19), (Ra1, Rb2, Rc3, Rd20), (Ra1, Rb2, Rc3, Rd21), (Ra1, Rb2, Rc3, Rd22), (Ra1, Rb2, Rc3, Rd23), (Ra1, Rb2, Rc3, Rd24), (Ra1, R b2, Rc3, Rd25), (Ra1, Rb2, Rc3, Rd26), (Ra1, Rb2, Rc3, Rd27), (Ra1, Rb2, Rc3, Rd28), (Ra1, Rb2, Rc3, Rd29), (Ra1, Rb2, Rc4, Rd1), (Ra1, Rb2, Rc4, Rd2), (Ra1, Rb2, Rc4, Rd3), (Ra1, Rb2, Rc4, Rd4), (Ra1, Rb2, Rc4, Rd5), (Ra1, Rb2, Rc4, Rd6), (Ra1, Rb2, Rc4, Rd7), (Ra1, Rb2, Rc4, Rd8), (Ra1, Rb2, Rc4, Rd9), (Ra1, Rb2, Rc4, Rd10), (Ra1, Rb2, Rc4, Rd11), (Ra1, Rb2, Rc4, Rd12), (Ra1, Rb2, Rc4, Rd13), (Ra1, Rb2, Rc4, Rd14), (Ra1, Rb2, Rc4, Rd15), (Ra1, Rb2, Rc4, Rd16), (Ra1, Rb2, Rc4, Rd17), (Ra1, Rb2, Rc4, Rd18), (Ra1, Rb2, Rc4, Rd19), (Ra1, Rb2, Rc4, Rd20), (Ra1, Rb2, Rc4, Rd21), (Ra1, Rb2, Rc4, Rd22), (Ra1, Rb2, Rc4, Rd23), (Ra1, Rb2, Rc4, Rd24), (Ra1, Rb2, Rc4, Rd25), (Ra1, Rb2, Rc4, Rd26), (Ra1, Rb2, Rc4, Rd27), (Ra1, Rb2, Rc4, Rd28), (Ra1, Rb2, Rc4, Rd29), (Ra1, Rb2, Rc5, Rd1), (Ra1, Rb2, Rc5, Rd2), (Ra1, Rb2, Rc5, Rd3), (Ra1, Rb2, Rc5, Rd 4), (Ra1, Rb2, Rc5, Rd5), (Ra1, Rb2, Rc5, Rd6), (Ra1, Rb2, Rc5, Rd7), (Ra1, Rb2, Rc5, Rd8), (Ra1, Rb2, Rc5, Rd9), (Ra1, Rb2, Rc5, Rd10), (Ra1, Rb2, Rc5, Rd11), (Ra1, Rb2, Rc5, Rd12), (Ra1, Rb2, Rc5, Rd13), (Ra1, Rb2, Rc5, Rd14), (Ra1, Rb2, Rc5, Rd15), (Ra1, Rb2, Rc5, Rd16), (Ra1, Rb2, Rc5, Rd17), (Ra1, Rb2, Rc5, Rd18), (Ra1, Rb2, Rc5, Rd19), (Ra1, Rb2, Rc5, Rd20), (Ra1, Rb2, Rc5, Rd21), (Ra1, Rb2, Rc5, Rd22), (Ra1, Rb2, Rc5, Rd23), (Ra1, Rb2, Rc5, Rd24), (Ra1, Rb2, Rc5, Rd25), (Ra1, Rb2, Rc5, Rd26), (Ra1, Rb2, Rc5, Rd27), (Ra1, Rb2, Rc5, Rd28), (Ra1, Rb2, Rc5, Rd29), (Ra2, Rb1, Rc1, Rd1), (Ra2, Rb1, Rc1, Rd2), (Ra2, Rb1, Rc1, Rd3), (Ra2, Rb1, Rc1, Rd4), (Ra2, Rb1, Rc1, Rd5), (Ra2, Rb1, Rc1, Rd6), (Ra2, Rb1, Rc1, Rd7), (Ra2, Rb1, Rc1, Rd8), (Ra2, Rb1, Rc1, Rd9), (Ra2, Rb1, Rc1, Rd10), (Ra2, Rb1, Rc1, Rd11), (Ra2, Rb1, Rc1, Rd12), (Ra2, Rb1 , Rc1, Rd13), (Ra2, Rb1, Rc1, Rd14), (Ra2, Rb1, Rc1, Rd15), (Ra2, Rb1, Rc1, Rd16), (Ra2, Rb1, Rc1, Rd17), (Ra2, Rb1 , Rc1, Rd18), (Ra2, Rb1, Rc1, Rd19), (Ra2, Rb1, Rc1, Rd20), (Ra2, Rb1, Rc1, Rd21), (Ra2, Rb1, Rc1, Rd22), (Ra2, Rb1 , Rc1, Rd23), (Ra2, Rb1, Rc1, Rd24), (Ra2, Rb1, Rc1, Rd25), (Ra2, Rb1, Rc1, Rd26), (Ra2, Rb1, Rc1, Rd27), (Ra2, Rb1 , Rc1, Rd28), (Ra2, Rb1, Rc1, Rd29), (Ra2, Rb1, Rc2, Rd1), (Ra2, Rb1, Rc2, Rd2), (Ra2, Rb1, Rc2, Rd3), (Ra2, Rb1 , Rc2, Rd4), (Ra2, Rb1, Rc2, Rd5), (Ra2, Rb1, Rc2, Rd6), (Ra2, Rb1, Rc2, Rd7), (Ra2, Rb1, Rc2, Rd8), (Ra2, Rb1 , Rc2, Rd9), (Ra2, Rb1, Rc2, Rd10), (Ra2, Rb1, Rc2, Rd11), (Ra2, Rb1, Rc2, Rd12), (Ra2, Rb1, Rc2, Rd13), (Ra2, Rb1 , Rc2, Rd14), (Ra2, Rb1, Rc2, Rd15), (Ra2, Rb1, Rc2, Rd16), (Ra2, Rb1, Rc2, Rd17), (Ra2, Rb1, Rc2, Rd18), (Ra2, Rb1 , Rc2, Rd19), (Ra2, Rb1, Rc2, Rd20), (Ra2, Rb1, Rc2, R d21), (Ra2, Rb1, Rc2, Rd22), (Ra2, Rb1, Rc2, Rd23), (Ra2, Rb1, Rc2, Rd24), (Ra2, Rb1, Rc2, Rd25), (Ra2, Rb1, Rc2, Rd26), (Ra2, Rb1, Rc2, Rd27), (Ra2, Rb1, Rc2, Rd28), (Ra2, Rb1, Rc2, Rd29), (Ra2, Rb1, Rc3, Rd1), (Ra2, Rb1, Rc3, Rd2), (Ra2, Rb1, Rc3, Rd3), (Ra2, Rb1, Rc3, Rd4), (Ra2, Rb1, Rc3, Rd5), (Ra2, Rb1, Rc3, Rd6), (Ra2, Rb1, Rc3, Rd7), (Ra2, Rb1, Rc3, Rd8), (Ra2, Rb1, Rc3, Rd9), (Ra2, Rb1, Rc3, Rd10), (Ra2, Rb1, Rc3, Rd11), (Ra2, Rb1, Rc3, Rd12), (Ra2, Rb1, Rc3, Rd13), (Ra2, Rb1, Rc3, Rd14), (Ra2, Rb1, Rc3, Rd15), (Ra2, Rb1, Rc3, Rd16), (Ra2, Rb1, Rc3, Rd17), (Ra2, Rb1, Rc3, Rd18), (Ra2, Rb1, Rc3, Rd19), (Ra2, Rb1, Rc3, Rd20), (Ra2, Rb1, Rc3, Rd21), (Ra2, Rb1, Rc3, Rd22), (Ra2, Rb1, Rc3, Rd23), (Ra2, Rb1, Rc3, Rd24), (Ra2, Rb1, Rc3, Rd25), (Ra2, Rb1, Rc3, Rd26), (Ra2, Rb1, Rc3, Rd27), (Ra2, Rb1, Rc3, Rd28), (Ra2, Rb1, Rc3, Rd29), (Ra 2, Rb1, Rc4, Rd1), (Ra2, Rb1, Rc4, Rd2), (Ra2, Rb1, Rc4, Rd3), (Ra2, Rb1, Rc4, Rd4), (Ra2, Rb1, Rc4, Rd5), ( (Ra2, Rb1, Rc4, Rd6), (Ra2, Rb1, Rc4, Rd7), (Ra2, Rb1, Rc4, Rd8), (Ra2, Rb1, Rc4, Rd9), (Ra2, Rb1, Rc4, Rd10), ( Ra2, Rb1, Rc4, Rd11), (Ra2, Rb1, Rc4, Rd12), (Ra2, Rb1, Rc4, Rd13), (Ra2, Rb1, Rc4, Rd14), (Ra2, Rb1, Rc4, Rd15), ( Ra2, Rb1, Rc4, Rd16), (Ra2, Rb1, Rc4, Rd17), (Ra2, Rb1, Rc4, Rd18), (Ra2, Rb1, Rc4, Rd19), (Ra2, Rb1, Rc4, Rd20), ( (Ra2, Rb1, Rc4, Rd21), (Ra2, Rb1, Rc4, Rd22), (Ra2, Rb1, Rc4, Rd23), (Ra2, Rb1, Rc4, Rd24), (Ra2, Rb1, Rc4, Rd25), ( Ra2, Rb1, Rc4, Rd26), (Ra2, Rb1, Rc4, Rd27), (Ra2, Rb1, Rc4, Rd28), (Ra2, Rb1, Rc4, Rd29), (Ra2, Rb1, Rc5, Rd1), ( (Ra2, Rb1, Rc5, Rd2), (Ra2, Rb1, Rc5, Rd3), (Ra2, Rb1, Rc5, Rd4), (Ra2, Rb1, Rc5, Rd5), (Ra2, Rb1, Rc5, Rd6), ( Ra2, Rb1, Rc5, Rd7), (Ra2, Rb1, Rc5, Rd8), (Ra2, Rb1, Rc5, Rd 9), (Ra2, Rb1, Rc5, Rd10), (Ra2, Rb1, Rc5, Rd11), (Ra2, Rb1, Rc5, Rd12), (Ra2, Rb1, Rc5, Rd13), (Ra2, Rb1, Rc5, Rd14), (Ra2, Rb1, Rc5, Rd15), (Ra2, Rb1, Rc5, Rd16), (Ra2, Rb1, Rc5, Rd17), (Ra2, Rb1, Rc5, Rd18), (Ra2, Rb1, Rc5, Rd19), (Ra2, Rb1, Rc5, Rd20), (Ra2, Rb1, Rc5, Rd21), (Ra2, Rb1, Rc5, Rd22), (Ra2, Rb1, Rc5, Rd23), (Ra2, Rb1, Rc5, Rd24), (Ra2, Rb1, Rc5, Rd25), (Ra2, Rb1, Rc5, Rd26), (Ra2, Rb1, Rc5, Rd27), (Ra2, Rb1, Rc5, Rd28), (Ra2, Rb1, Rc5, Rd29), (Ra2, Rb2, Rc1, Rd1), (Ra2, Rb2, Rc1, Rd2), (Ra2, Rb2, Rc1, Rd3), (Ra2, Rb2, Rc1, Rd4), (Ra2, Rb2, Rc1, Rd5), (Ra2, Rb2, Rc1, Rd6), (Ra2, Rb2, Rc1, Rd7), (Ra2, Rb2, Rc1, Rd8), (Ra2, Rb2, Rc1, Rd9), (Ra2, Rb2, Rc1, Rd10), (Ra2, Rb2, Rc1, Rd11), (Ra2, Rb2, Rc1, Rd12), (Ra2, Rb2, Rc1, Rd13), (Ra2, Rb2, Rc1, Rd14), (Ra2, Rb2, Rc1, Rd15), (Ra2, Rb2, Rc1, Rd16), (Ra2, Rb2, Rc1, Rd17), (Ra2, Rb2, Rc1, Rd18), (Ra2, Rb2, Rc1, Rd19), (Ra2, Rb2, Rc1, Rd20), (Ra2, Rb2, Rc1, Rd21), (Ra2, Rb2, Rc1, Rd22), (Ra2, Rb2, Rc1, Rd23), (Ra2, Rb2, Rc1, Rd24), (Ra2, Rb2, Rc1, Rd25), (Ra2, Rb2, Rc1, Rd26), (Ra2, Rb2, Rc1, Rd27), (Ra2, Rb2, Rc1, Rd28), (Ra2, Rb2, Rc1, Rd29), (Ra2, Rb2, Rc2, Rd1), (Ra2, Rb2, Rc2, Rd2), (Ra2, Rb2, Rc2, Rd3), (Ra2, Rb2, Rc2, Rd4), (Ra2, Rb2, Rc2, Rd5), (Ra2, Rb2, Rc2, Rd6), (Ra2, Rb2, Rc2, Rd7), (Ra2, Rb2, Rc2, Rd8), (Ra2, Rb2, Rc2, Rd9), (Ra2, Rb2, Rc2, Rd10), (Ra2, Rb2, Rc2, Rd11), (Ra2, Rb2, Rc2, Rd12), (Ra2, Rb2, Rc2, Rd13), (Ra2, Rb2, Rc2, Rd14), (Ra2, Rb2, Rc2, Rd15), (Ra2, Rb2, Rc2, Rd16),

(Ra2, Rb2, Rc2, Rd17), (Ra2, Rb2, Rc2, Rd18), (Ra2, Rb2, Rc2, Rd19), (Ra2, Rb2, Rc2, Rd20), (Ra2, Rb2, Rc2, Rd21), (Ra2, Rb2, Rc2, Rd22), (Ra2, Rb2, Rc2, Rd23), (Ra2, Rb2, Rc2, Rd24), (Ra2, Rb2, Rc2, Rd25), (Ra2, Rb2, Rc2, Rd26), (Ra2, Rb2, Rc2, Rd27), (Ra2, Rb2, Rc2, Rd28), (Ra2, Rb2, Rc2, Rd29), (Ra2, Rb2, Rc3, Rd1), (Ra2, Rb2, Rc3, Rd2), (Ra2, Rb2, Rc3, Rd3), (Ra2, Rb2, Rc3, Rd4), (Ra2, Rb2, Rc3, Rd5), (Ra2, Rb2, Rc3, Rd6), (Ra2, Rb2, Rc3, Rd7), (Ra2, Rb2, Rc3, Rd8), (Ra2, Rb2, Rc3, Rd9), (Ra2, Rb2, Rc3, Rd10), (Ra2, Rb2, Rc3, Rd11), (Ra2, Rb2, Rc3, Rd12), (Ra2, Rb2, Rc3, Rd13), (Ra2, Rb2, Rc3, Rd14), (Ra2, Rb2, Rc3, Rd15), (Ra2, Rb2, Rc3, Rd16), (Ra2, Rb2, Rc3, Rd17), (Ra2, Rb2, Rc3, Rd18), (Ra2, Rb2, Rc3, Rd19), (Ra2, Rb2, Rc3, Rd20), (Ra2, Rb2, Rc3, Rd21), (Ra2, Rb2, Rc3, Rd22), (Ra2, Rb2, Rc3, Rd23), (Ra2, Rb2, Rc3, Rd24), (Ra2, R b2, Rc3, Rd25), (Ra2, Rb2, Rc3, Rd26), (Ra2, Rb2, Rc3, Rd27), (Ra2, Rb2, Rc3, Rd28), (Ra2, Rb2, Rc3, Rd29), (Ra2, Rb2, Rc4, Rd1), (Ra2, Rb2, Rc4, Rd2), (Ra2, Rb2, Rc4, Rd3), (Ra2, Rb2, Rc4, Rd4), (Ra2, Rb2, Rc4, Rd5), (Ra2, Rb2, Rc4, Rd6), (Ra2, Rb2, Rc4, Rd7), (Ra2, Rb2, Rc4, Rd8), (Ra2, Rb2, Rc4, Rd9), (Ra2, Rb2, Rc4, Rd10), (Ra2, Rb2, Rc4, Rd11), (Ra2, Rb2, Rc4, Rd12), (Ra2, Rb2, Rc4, Rd13), (Ra2, Rb2, Rc4, Rd14), (Ra2, Rb2, Rc4, Rd15), (Ra2, Rb2, Rc4, Rd16), (Ra2, Rb2, Rc4, Rd17), (Ra2, Rb2, Rc4, Rd18), (Ra2, Rb2, Rc4, Rd19), (Ra2, Rb2, Rc4, Rd20), (Ra2, Rb2, Rc4, Rd21), (Ra2, Rb2, Rc4, Rd22), (Ra2, Rb2, Rc4, Rd23), (Ra2, Rb2, Rc4, Rd24), (Ra2, Rb2, Rc4, Rd25), (Ra2, Rb2, Rc4, Rd26), (Ra2, Rb2, Rc4, Rd27), (Ra2, Rb2, Rc4, Rd28), (Ra2, Rb2, Rc4, Rd29), (Ra2, Rb2, Rc5, Rd1), (Ra2, Rb2, Rc5, Rd2), (Ra2, Rb2, Rc5, Rd3), (Ra2, Rb2, Rc5, Rd 4), (Ra2, Rb2, Rc5, Rd5), (Ra2, Rb2, Rc5, Rd6), (Ra2, Rb2, Rc5, Rd7), (Ra2, Rb2, Rc5, Rd8), (Ra2, Rb2, Rc5, Rd9), (Ra2, Rb2, Rc5, Rd10), (Ra2, Rb2, Rc5, Rd11), (Ra2, Rb2, Rc5, Rd12), (Ra2, Rb2, Rc5, Rd13), (Ra2, Rb2, Rc5, Rd14), (Ra2, Rb2, Rc5, Rd15), (Ra2, Rb2, Rc5, Rd16), (Ra2, Rb2, Rc5, Rd17), (Ra2, Rb2, Rc5, Rd18), (Ra2, Rb2, Rc5, Rd19), (Ra2, Rb2, Rc5, Rd20), (Ra2, Rb2, Rc5, Rd21), (Ra2, Rb2, Rc5, Rd22), (Ra2, Rb2, Rc5, Rd23), (Ra2, Rb2, Rc5, Rd24), (Ra2, Rb2, Rc5, Rd25), (Ra2, Rb2, Rc5, Rd26), (Ra2, Rb2, Rc5, Rd27), (Ra2, Rb2, Rc5, Rd28), (Ra2, Rb2, Rc5, Rd29), (Ra3, Rb1, Rc1, Rd1), (Ra3, Rb1, Rc1, Rd2), (Ra3, Rb1, Rc1, Rd3), (Ra3, Rb1, Rc1, Rd4), (Ra3, Rb1, Rc1, Rd5), (Ra3, Rb1, Rc1, Rd6), (Ra3, Rb1, Rc1, Rd7), (Ra3, Rb1, Rc1, Rd8), (Ra3, Rb1, Rc1, Rd9), (Ra3, Rb1, Rc1, Rd10), (Ra3, Rb1, Rc1, Rd11), (Ra3, Rb1, Rc1, Rd12), (Ra3, Rb1 , Rc1, Rd13), (Ra3, Rb1, Rc1, Rd14), (Ra3, Rb1, Rc1, Rd15), (Ra3, Rb1, Rc1, Rd16), (Ra3, Rb1, Rc1, Rd17), (Ra3, Rb1 , Rc1, Rd18), (Ra3, Rb1, Rc1, Rd19), (Ra3, Rb1, Rc1, Rd21), (Ra3, Rb1, Rc1, Rd22), (Ra3, Rb1 , Rc1, Rd23), (Ra3, Rb1, Rc1, Rd24), (Ra3, Rb1, Rc1, Rd25), (Ra3, Rb1, Rc1, Rd26), (Ra3, Rb1, Rc1, Rd27), (Ra3, Rb1 , Rc1, Rd28), (Ra3, Rb1, Rc1, Rd29), (Ra3, Rb1, Rc2, Rd1), (Ra3, Rb1, Rc2, Rd2), (Ra3, Rb1, Rc2, Rd3), (Ra3, Rb1 , Rc2, Rd4), (Ra3, Rb1, Rc2, Rd5), (Ra3, Rb1, Rc2, Rd6), (Ra3, Rb1, Rc2, Rd7), (Ra3, Rb1, Rc2, Rd8), (Ra3, Rb1 , Rc2, Rd9), (Ra3, Rb1, Rc2, Rd10), (Ra3, Rb1, Rc2, Rd11), (Ra3, Rb1, Rc2, Rd12), (Ra3, Rb1, Rc2, Rd13), (Ra3, Rb1 , Rc2, Rd14), (Ra3, Rb1, Rc2, Rd16), (Ra3, Rb1, Rc2, Rd17), (Ra3, Rb1, Rc2, Rd18), (Ra3, Rb1) , Rc2, Rd19), (Ra3, Rb1, Rc2, Rd20), (Ra3, Rb1, Rc2, R d21), (Ra3, Rb1, Rc2, Rd22), (Ra3, Rb1, Rc2, Rd23), (Ra3, Rb1, Rc2, Rd24), (Ra3, Rb1, Rc2, Rd25), (Ra3, Rb1, Rc2, Rd26), (Ra3, Rb1, Rc2, Rd27), (Ra3, Rb1, Rc2, Rd28), (Ra3, Rb1, Rc2, Rd29), (Ra3, Rb1, Rc3, Rd1), (Ra3, Rb1, Rc3, Rd2), (Ra3, Rb1, Rc3, Rd3), (Ra3, Rb1, Rc3, Rd4), (Ra3, Rb1, Rc3, Rd5), (Ra3, Rb1, Rc3, Rd6), (Ra3, Rb1, Rc3, Rd7), (Ra3, Rb1, Rc3, Rd8), (Ra3, Rb1, Rc3, Rd9), (Ra3, Rb1, Rc3, Rd10), (Ra3, Rb1, Rc3, Rd11), (Ra3, Rb1, Rc3, Rd12), (Ra3, Rb1, Rc3, Rd13), (Ra3, Rb1, Rc3, Rd14), (Ra3, Rb1, Rc3, Rd15), (Ra3, Rb1, Rc3, Rd16), (Ra3, Rb1, Rc3, Rd17), (Ra3, Rb1, Rc3, Rd18), (Ra3, Rb1, Rc3, Rd19), (Ra3, Rb1, Rc3, Rd20), (Ra3, Rb1, Rc3, Rd21), (Ra3, Rb1, Rc3, Rd22), (Ra3, Rb1, Rc3, Rd23), (Ra3, Rb1, Rc3, Rd24), (Ra3, Rb1, Rc3, Rd25), (Ra3, Rb1, Rc3, Rd26), (Ra3, Rb1, Rc3, Rd27), (Ra3, Rb1, Rc3, Rd28), (Ra3, Rb1, Rc3, Rd29), (Ra 3, Rb1, Rc4, Rd1), (Ra3, Rb1, Rc4, Rd2), (Ra3, Rb1, Rc4, Rd3), (Ra3, Rb1, Rc4, Rd4), (Ra3, Rb1, Rc4, Rd5), (Ra3, Rb1, Rc4, Rd6), (Ra3, Rb1, Rc4, Rd7), (Ra3, Rb1, Rc4, Rd8), (Ra3, Rb1, Rc4, Rd9), (Ra3, Rb1, Rc4, Rd10), (Ra3, Rb1, Rc4, Rd11), (Ra3, Rb1, Rc4, Rd12), (Ra3, Rb1, Rc4, Rd13), (Ra3, Rb1, Rc4, Rd14), (Ra3, Rb1, Rc4, Rd15), (Ra3, Rb1, Rc4, Rd16), (Ra3, Rb1, Rc4, Rd17), (Ra3, Rb1, Rc4, Rd18), (Ra3, Rb1, Rc4, Rd19), (Ra3, Rb1, Rc4, Rd20), (Ra3, Rb1, Rc4, Rd21), (Ra3, Rb1, Rc4, Rd22), (Ra3, Rb1, Rc4, Rd23), (Ra3, Rb1, Rc4, Rd24), (Ra3, Rb1, Rc4, Rd25), (Ra3, Rb1, Rc4, Rd26), (Ra3, Rb1, Rc4, Rd27), (Ra3, Rb1, Rc4, bRd28), (Ra3, Rb1, Rc4, Rd29), (Ra3, Rb1, Rc5, Rd1), (Ra3, Rb1, Rc5, Rd2), (Ra3, Rb1, Rc5, Rd3), (Ra3, Rb1, Rc5, Rd4), (Ra3, Rb1, Rc5, Rd5), (Ra3, Rb1, Rc5, Rd6), Ra3, Rb1, cRc5, Rd7), (Ra3, Rb1, Rc5, Rd8), (Ra3, Rb1, Rc5, Rd 9), (Ra3, Rb1, Rc5, Rd10), (Ra3, Rb1, Rc5, Rd11), (Ra3, Rb1, Rc5, Rd12), (Ra3, Rb1, Rc5, Rd13), (Ra3, Rb1, Rc5, Rd14), (Ra3, Rb1, Rc5, Rd15), (Ra3, Rb1, Rc5, Rd16), (Ra3, Rb1, Rc5, Rd17), (Ra3, Rb1, Rc5, Rd18), (Ra3, Rb1, Rc5, Rd19), (Ra3, Rb1, Rc5, Rd20), (Ra3, Rb1, Rc5, Rd21), (Ra3, Rb1, Rc5, Rd22), (Ra3, Rb1, Rc5, Rd23), (Ra3, Rb1, Rc5, Rd24), (Ra3, Rb1, Rc5, Rd25), (Ra3, Rb1, Rc5, Rd26), (Ra3, Rb1, Rc5, Rd27), (Ra3, Rb1, Rc5, Rd28), (Ra3, Rb1, Rc5, Rd29), (Ra3, Rb2, Rc1, Rd1), (Ra3, Rb2, Rc1, Rd2), (Ra3, Rb2, Rc1, Rd3), (Ra3, Rb2, Rc1, Rd4), (Ra3, Rb2, Rc1, Rd5), (Ra3, Rb2, Rc1, Rd6), (Ra3, Rb2, Rc1, Rd7),

(Ra3, Rb2, Rc1, Rd8), (Ra3, Rb2, Rc1, Rd9), (Ra3, Rb2, Rc1, Rd10), (Ra3, Rb2, Rc1, Rd11), (Ra3, Rb2, Rc1, Rd12), (Ra3, Rb2, Rc1, Rd13), (Ra3, Rb2, Rc1, Rd15), (Ra3, Rb2, Rc1, Rd16), (Ra3, Rb2, Rc1, Rd17), (Ra3, Rb2, Rc1, Rd18), (Ra3, Rb2, Rc1, Rd20), (Ra3, Rb2, Rc1, Rd21), (Ra3, Rb2, Rc1, Rd22), (Ra3, Rb2, Rc1, Rd23), (Ra3, Rb2, Rc1, Rd25), (Ra3, Rb2, Rc1, Rd26), (Ra3, Rb2, Rc1, Rd27), (Ra3, Rb2, Rc2, Rd28), (Ra3, Rb2, Rc2, Rd1), (Ra3, Rb2, Rc2, Rd2), (Ra3, Rb2, Rc2, Rd3), (Ra3, Rb2, Rc2, Rd4), (Ra3, Rb2, Rc2, Rd6), (Ra3, Rb2, Rc2, Rd7), (Ra3, Rb2, Rc2, Rd8), (Ra3, Rb2, Rc2, Rd9), (Ra3, Rb2, Rc2, Rd11), (Ra3, Rb2, Rc2, Rd12), (Ra3, Rb2, Rc2, Rd13), (Ra3, Rb2, Rc2, Rd14), (Ra3, Rb2, Rc2, Rd15), (Ra3, Rb2 , Rc2, Rd16), (Ra3, Rb2, Rc2, Rd17), (Ra3, Rb2, Rc2, 3Rd19), (Ra3, Rb2, Rc2, Rd20), (Ra3, Rb2 , Rc2, Rd21), (Ra3, Rb2, Rc2, Rd22), (Ra3, Rb2, Rc2, Rd23), (Ra3, Rb2, Rc2, Rd24), (Ra3, Rb2, Rc2, Rd25), (Ra3, Rb2 , Rc2, Rd26), (Ra3, Rb2, Rc2, Rd27), (Ra3, Rb2, Rc2, Rd28), (Ra3, Rb2, Rc2, Rd29), (Ra3, Rb2, Rc3, Rd1), (Ra3, Rb2 , Rc3, Rd2), (Ra3, Rb2, Rc3, Rd3), (Ra3, Rb2, Rc3, Rd4), (Ra3, Rb2, Rc3, Rd5), (Ra3, Rb2, Rc3, Rd6), (Ra3, Rb2) , Rc3, Rd7), (Ra3, Rb2, Rc3, Rd8), (Ra3, Rb2, Rc3, Rd9), (Ra3, Rb2, Rc3, Rd10), (Ra3, Rb2, Rc3, Rd11), (Ra3, Rb2) , Rc3, Rd12), (Ra3, Rb2, Rc3, Rd13), (Ra3, Rb2, Rc3, Rd14), (Ra3, Rb2, Rc3, Rd15), (Ra3, Rb2, Rc3, Rd16), (Ra3, Rb2) , Rc3, Rd17), (Ra3, Rb2, Rc3, Rd19), (Ra3, Rb2, Rc3, Rd21), (Ra3, Rb2, Rc3, Rd21), (Ra3, Rb2) , Rc3, Rd22), (Ra3, Rb2, Rc3, 、 Rd23), (Ra3, Rb2, Rc3, R d24), (Ra3, Rb2, Rc3, Rd25), (Ra3, Rb2, Rc3, Rd26), (Ra3, Rb2, Rc3, Rd27), (Ra3, Rb2, Rc3, Rd28), (Ra3, Rb2, Rc3, Rd29), (Ra3, Rb2, Rc4, Rd1), (Ra3, Rb2, Rc4, Rd2), (Ra3, Rb2, Rc4, Rd3), (Ra3, Rb2, Rc4, Rd4), (Ra3, Rb2, Rc4, Rd5), (Ra3, Rb2, Rc4, Rd6), (Ra3, Rb2, Rc4, Rd7), (Ra3, Rb2, Rc4, Rd8), (Ra3, Rb2, Rc4, Rd9), (Ra3, Rb2, Rc4, Rd10), (Ra3, Rb2, Rc4, Rd11), (Ra3, Rb2, Rc4, Rd12), (Ra3, Rb2, Rc4, Rd13), (Ra3, Rb2, Rc4, Rd14), (Ra3, Rb2, Rc4, Rd15), (Ra3, Rb2, Rc4, Rd16), (Ra3, Rb2, Rc4, Rd17), (Ra3, Rb2, Rc4, Rd18), (Ra3, Rb2, Rc4, Rd19), (Ra3, Rb2, Rc4, Rd20), (Ra3, Rb2, Rc4, Rd21), (Ra3, Rb2, Rc4, Rd22), (Ra3, Rb2, Rc4, Rd23), (Ra3, Rb2, Rc4, Rd24), (Ra3, Rb2, Rc4, Rd25), (Ra3, Rb2, Rc4, Rd26), (Ra3, Rb2, Rc4, Rd27), (Ra3, Rb2, Rc4, Rd28), (Ra3, Rb2, Rc4, Rd29), (Ra3, Rb2, Rc5, Rd1), (Ra3, Rb2, Rc5, Rd2), (Ra3, Rb2, Rc5, Rd3), (Ra3, Rb2, Rc5, Rd4), (Ra3, Rb2, Rc5, Rd5), (Ra3, Rb2, Rc5, Rd6), (Ra3, Rb2, Rc5, Rd7), (Ra3, Rb2, Rc5, Rd8), (Ra3, Rb2, Rc5, Rd9), (Ra3, Rb2, Rc5, Rd10), (Ra3, Rb2, Rc5, Rd11), (Ra3, Rb2, Rc5, Rd12), (Ra3, Rb2, Rc5, Rd13), (Ra3, Rb2, Rc5, Rd14), (Ra3, Rb2, Rc5, Rd15), (Ra3, Rb2, Rc5, Rd16), (Ra3, Rb2, Rc5, Rd17), (Ra3, Rb2, Rc5, Rd18), (Ra3, Rb2, Rc5, Rd19), (Ra3, Rb2, Rc5, Rd20), (Ra3, Rb2, Rc5, Rd21), (Ra3, Rb2, Rc5, Rd22), (Ra3, Rb2, Rc5, Rd23), (Ra3, Rb2, Rc5, Rd24), (Ra3, Rb2, Rc5, Rd25), (Ra3, Rb2, Rc5, Rd26), (Ra3, Rb2, Rc5, Rd27), (Ra3, Rb2, Rc5, Rd28), (Ra3, Rb2, Rc5, Rd29), (Ra4, Rb1, Rc1, Rd1), (Ra4, Rb1, Rc1, Rd2), (Ra4, Rb1, Rc1, Rd3), (Ra4, Rb1, Rc1, Rd4), (Ra4, Rb1, Rc1, Rd5), (Ra4, Rb1, Rc1, Rd6), (Ra4, Rb1, Rc1, Rd7), (Ra4, Rb1, Rc1, Rd8), (Ra4, Rb1, Rc1, Rd9), (Ra4, Rb1, Rc1, Rd10), (Ra4, Rb1, Rc1, Rd11), (Ra4, Rb1, Rc1, Rd1 2), (Ra4, Rb1, Rc1, Rd13), (Ra4, Rb1, Rc1, Rd14), (Ra4, Rb1, Rc1, Rd15), (Ra4, Rb1, Rc1, Rd16), (Ra4, Rb1, Rc1, Rd17), (Ra4, Rb1, Rc1, Rd18), (Ra4, Rb1, Rc1, Rd19), (Ra4, Rb1, Rc1, Rd20), (Ra4, Rb1, Rc1, Rd21), (Ra4, Rb1, Rc1, Rd22), (Ra4, Rb1, Rc1, Rd23), (Ra4, Rb1, Rc1, Rd24), (Ra4, Rb1, Rc1, Rd25), (Ra4, Rb1, Rc1, Rd26), (Ra4, Rb1, Rc1, Rd27), (Ra4, Rb1, Rc1, Rd28), (Ra4, Rb1, Rc1, Rd29), (Ra4, Rb1, Rc2, Rd1), (Ra4, Rb1, Rc2, Rd2), (Ra4, Rb1, Rc2, Rd3), (Ra4, Rb1, Rc2, Rd4), (Ra4, Rb1, Rc2, Rd5), (Ra4, Rb1, Rc2, Rd6), (Ra4, Rb1, Rc2, Rd7), (Ra4, Rb1, Rc2, Rd8), (Ra4, Rb1, Rc2, Rd9), (Ra4, Rb1, Rc2, Rd10), (Ra4, Rb1, Rc2, Rd11), (Ra4, Rb1, Rc2, Rd12), (Ra4, Rb1, Rc2, Rd13), (Ra4, Rb1, Rc2, Rd14), (Ra4, Rb1, Rc2, Rd15), (Ra4, Rb1, Rc2, Rd16), (Ra4, Rb1, Rc2, Rd17), (Ra4, Rb1, Rc2, Rd18), (Ra4, Rb1, Rc2, Rd19), (Ra4, Rb1, Rc2, Rd20), (Ra4, Rb1, Rc2, Rd21), (Ra4, Rb1, Rc2, Rd22), (Ra4, Rb1, Rc2, Rd23), (Ra4, Rb1, Rc2, Rd24), (Ra4, Rb1, Rc2, Rd25), (Ra4, Rb1, Rc2, Rd26), (Ra4, Rb1, Rc2, Rd27), (Ra4, Rb1, Rc2, Rd28), (Ra4, Rb1, Rc2, Rd29), (Ra4, Rb1, Rc3, Rd1), (Ra4, Rb1, Rc3, Rd2), (Ra4, Rb1, Rc3, Rd3), (Ra4, Rb1, Rc3, Rd4), (Ra4, Rb1, Rc3, Rd5), (Ra4, Rb1, Rc3, Rd6), (Ra4, Rb1, Rc3, Rd7), (Ra4, Rb1, Rc3, Rd8), (Ra4, Rb1, Rc3, Rd9), (Ra4, Rb1, Rc3, Rd10), (Ra4, Rb1, Rc3, Rd11), (Ra4, Rb1, Rc3, Rd12), (Ra4, Rb1, Rc3, Rd13), (Ra4, Rb1, Rc3, Rd14), (Ra4, Rb1, Rc3, Rd15), (Ra4, Rb1, Rc3, Rd16), (Ra4, Rb1, Rc3, Rd17), (Ra4, Rb1, Rc3, Rd18), (Ra4, Rb1, Rc3, Rd19), (Ra4, Rb1, Rc3, Rd20), (Ra4, Rb1, Rc3, Rd21), (Ra4, Rb1, Rc3, Rd22), (Ra4, Rb1, Rc3, Rd23), (Ra4, Rb1, Rc3, Rd24), (Ra4, Rb1, Rc3, Rd25), (Ra4, Rb1, Rc3, Rd26), (Ra4, Rb1, Rc3, Rd27), (Ra4, Rb1, Rc3, Rd28), (Ra4, Rb1, Rc 3, Rd29), (Ra4, Rb1, Rc4, Rd1), (Ra4, Rb1, Rc4, Rd2), (Ra4, Rb1, Rc4, Rd3), (Ra4, Rb1, Rc4, Rd4), (Ra4, Rb1, Rc4, Rd5), (Ra4, Rb1, Rc4, Rd6), (Ra4, Rb1, Rc4, Rd7), (Ra4, Rb1, Rc4, Rd8), (Ra4, Rb1, Rc4, Rd9), (Ra4, Rb1, Rc4, Rd10), (Ra4, Rb1, Rc4, Rd11), (Ra4, Rb1, Rc4, Rd12), (Ra4, Rb1, Rc4, Rd13), (Ra4, Rb1, Rc4, Rd14), (Ra4, Rb1, Rc4, Rd15), (Ra4, Rb1, Rc4, Rd16), (Ra4, Rb1, Rc4, Rd17), (Ra4, Rb1, Rc4, Rd18), (Ra4, Rb1, Rc4, Rd19), (Ra4, Rb1, Rc4, Rd20), (Ra4, Rb1, Rc4, Rd21), (Ra4, Rb1, Rc4, Rd22), (Ra4, Rb1, Rc4, Rd23), (Ra4, Rb1, Rc4, Rd24), (Ra4, Rb1, Rc4, Rd25), (Ra4, Rb1, Rc4, Rd26), (Ra4, Rb1, Rc4, Rd27), (Ra4, Rb1, Rc4, Rd28), (Ra4, Rb1, Rc4, Rd29), (Ra4, Rb1, Rc5, Rd1), (Ra4, Rb1, Rc5, Rd2), (Ra4, Rb1, Rc5, Rd3), (Ra4, Rb1, Rc5, Rd4), (Ra4, Rb1, Rc5, Rd5), (Ra4, Rb1, Rc5, Rd6), (Ra4, Rb1, Rc5, Rd7), (Ra4, Rb1, Rc5, Rd8), (Ra4, Rb1, Rc5, Rd9), (Ra4, Rb1, Rc5, Rd10), (Ra4, Rb1, Rc5, Rd11), (Ra4, Rb1, Rc5, Rd12), (Ra4, Rb1, Rc5, Rd13), (Ra4, Rb1, Rc5, Rd14), (Ra4, Rb1, Rc5, Rd15), (Ra4, Rb1, Rc5, Rd16), (Ra4, Rb1, Rc5, Rd17), (Ra4, Rb1, Rc5, Rd18), (Ra4, Rb1, Rc5, Rd19), (Ra4, Rb1, Rc5, Rd20), (Ra4, Rb1, Rc5, Rd21), (Ra4, Rb1, Rc5, Rd22), (Ra4, Rb1, Rc5, Rd23), (Ra4, Rb1, Rc5, Rd24), (Ra4, Rb1, Rc5, Rd25), (Ra4, Rb1, Rc5, Rd26), (Ra4, Rb1, Rc5, Rd27), (Ra4, Rb1, Rc5, Rd28),

(Ra4, Rb1, Rc5, Rd29), (Ra4, Rb2, Rc1, Rd1), (Ra4, Rb2, Rc1, Rd2), (Ra4, Rb2, Rc1, Rd3), (Ra4, Rb2, Rc1, Rd4), (Ra4, Rb2, Rc1, Rd5), (Ra4, Rb2, Rc1, Rd6), (Ra4, Rb2, Rc1, Rd7), (Ra4, Rb2, Rc1, Rd8), (Ra4, Rb2, Rc1, Rd9), (Ra4, Rb2, Rc1, Rd10), (Ra4, Rb2, Rc1, Rd12), (Ra4, Rb2, Rc1, Rd13), (Ra4, Rb2, Rc1, Rd14), (Ra4, Rb2, Rc1, Rd15), (Ra4, Rb2, Rc1, Rd17), (Ra4, Rb2, Rc1, Rd18), (Ra4, Rb2, Rc1, Rd19), (Ra4, Rb2, Rc1, Rd20), (Ra4, Rb2, Rc1, Rd21), (Ra4, Rb2, Rc1, Rd22), (Ra4, Rb2, Rc1, Rd23), (Ra4, Rb2, Rc1, Rd24), (Ra4, Rb2, Rc1, Rd25), (Ra4, Rb2, Rc1, Rd26), (Ra4, Rb2, Rc1, Rd27), (Ra4, Rb2, Rc1, Rd28), (Ra4, Rb2, Rc1, Rd29), (Ra4, Rb2, Rc2, Rd1), (Ra4, Rb2, Rc2, Rd3), (Ra4, Rb2, Rc2, Rd4), (Ra4, Rb2, Rc2, Rd5), (Ra4, Rb2, Rc2, Rd6), (Ra4, Rb2, Rc2, Rd7), (Ra4, Rb2, Rc 2, Rd8), (Ra4, Rb2, Rc2, Rd9), (Ra4, Rb2, Rc2, Rd10), (Ra4, Rb2, Rc2, Rd11), (Ra4, Rb2, Rc2, Rd12), (Ra4, Rb2, Rc2, Rd13), (Ra4, Rb2, Rc2, Rd14), (Ra4, Rb2, Rc2, Rd15), (Ra4, Rb2, Rc2, Rd16), (Ra4, Rb2, Rc2, Rd17), (Ra4, Rb2, Rc2, Rd18), (Ra4, Rb2, Rc2, Rd19), (Ra4, Rb2, Rc2, Rd20), (Ra4, Rb2, Rc2, Rd21), (Ra4, Rb2, Rc2, Rd22), (Ra4, Rb2, Rc2, Rd23), (Ra4, Rb2, Rc2, Rd24), (Ra4, Rb2, Rc2, Rd25), (Ra4, Rb2, Rc2, Rd26), (Ra4, Rb2, Rc2, Rd27), (Ra4, Rb2, Rc2, Rd28), (Ra4, Rb2, Rc2, Rd29), (Ra4, Rb2, Rc3, Rd1), (Ra4, Rb2, Rc3, Rd2), (Ra4, Rb2, Rc3, Rd3), (Ra4, Rb2, Rc3, Rd4), (Ra4, Rb2, Rc3, Rd5), (Ra4, Rb2, Rc3, Rd6), (Ra4, Rb2, Rc3, Rd7), (Ra4, Rb2, Rc3, Rd8), (Ra4, Rb2, Rc3, Rd9), (Ra4, Rb2, Rc3, Rd10), (Ra4, Rb2, Rc3, Rd11), (Ra4, Rb2, Rc3, Rd12), (Ra4, Rb2, Rc3, Rd13), (Ra4, Rb2, Rc3, Rd14), (Ra4, Rb2, Rc3, Rd15), (Ra4, Rb2, Rc3, Rd16), (Ra4, Rb2, Rc3, Rd17), (Ra4, Rb2, Rc3, Rd18), (Ra4, Rb2, Rc3, Rd19), (Ra4, Rb2, Rc3, Rd20), (Ra4, Rb2, Rc3, Rd21), (Ra4, Rb2, Rc3, Rd22), (Ra4, Rb2, Rc3, Rd23), (Ra4, Rb2,4Rc3, bRd24), (Ra4, Rb2, Rc3, Rd25), (Ra4, Rb2, Rc3, Rd26), (Ra4, Rb2, Rc3, Rd27), (Ra4, Rb2, Rc3, Rd28), (Ra4, Rb2, Rc3, Rd29), (Ra4, Rb2, Rc4, Rd1), (Ra4, Rb2, Rc4, Rd2), (Ra4, Rb2, Rc4, Rd3), (Ra4, Rb2, Rc4, Rd4), (Ra4, Rb2, Rc4, Rd5), (Ra4, Rb2, Rc4, Rd6), (Ra4, Rb2, Rc4, Rd7), (Ra4, Rb2, Rc4, Rd8), (Ra4, Rb2, Rc4, Rd9), (Ra4, Rb2, Rc4, Rd10), (Ra4, Rb2, (Rc4, bRd11), (Ra4, Rb2, Rc4, Rd12), (Ra4, Rb2, Rc4, Rd13), (Ra4, Rb2, Rc4, Rd14), (Ra4, Rb2, Rc4, Rd15), (Ra4, Rb2, Rc4, Rd16), (Ra4, Rb2, Rc4, Rd17), (Ra4, Rb2, Rc4, Rd18), (Ra4, Rb2, Rc4, Rd19), (Ra4, Rb2, Rc4, Rd20), (Ra4, Rb2, 、 Rc4, Rd21), (Ra4, Rb2, Rc4, Rd22), (Ra4, Rb2, Rc4, Rd23), (Ra4, Rb2, Rc4, Rd24), (Ra4, Rb2 , Rc4, Rd25), (Ra4, Rb2, Rc4, Rd26), (Ra4, Rb2, Rc4, Rd27), (Ra4, Rb2, Rc4, Rd28), (Ra4, Rb2, Rc4, Rd29), (Ra4, Rb2) , Rc5, Rd1), (Ra4, Rb2, Rc5, Rd2), (Ra4, Rb2, Rc5, Rd3), (Ra4, Rb2, Rc5, Rd4), (Ra4, Rb2, Rc5, Rd5), (Ra4, Rb2) , Rc5, Rd6), (Ra4, Rb2, Rc5, Rd7), (Ra4, Rb2, Rc5, Rd8), (Ra4, Rb2, Rc5, Rd9), (Ra4, Rb2, Rc5, Rd10), (Ra4, Rb2) , Rc5, Rd11), (Ra4, Rb2, Rc5, Rd12), (Ra4, Rb2, Rc5, Rd13), (Ra4, Rb2, Rc5, Rd14), (Ra4, Rb2, Rc5, Rd15), (Ra4, Rb2) , Rc5, Rd16), (Ra4, Rb2, Rc5, Rd17), (Ra4, Rb2, Rc5, Rd18), (Ra4, Rb2, Rc5, Rd19), (Ra4, Rb2, Rc5, Rd20), (Ra4, Rb2) , Rc5, Rd21), (Ra4, Rb2, Rc5, Rd22), (Ra4, Rb2, Rc5, Rd23), (Ra4, Rb2, Rc5, Rd24), (Ra4, Rb2, Rc5, Rd25), (Ra4, Rb2) , Rc5, Rd26), (Ra4, Rb2, Rc5, Rd27), (Ra4, Rb2, Rc5, Rd28), (Ra4, Rb2, Rc5, Rd29), (Ra5, Rb1, Rc1, Rd1), (Ra5, Rb1) , Rc1, Rd2), (Ra5, Rb1, Rc1, Rd3), (Ra5, Rb1, Rc1, Rd4) , (Ra5, Rb1, Rc1, Rd5), (Ra5, Rb1, Rc1, Rd6), (Ra5, Rb1, Rc1, Rd7), (Ra5, Rb1, Rc1, Rd8), (Ra5, Rb1, Rc1, Rd9) , (Ra5, Rb1, Rc1, 10Rd10), (Ra5, Rb1, Rc1, Rd11), (Ra5, Rb1, Rc1, Rd12), (Ra5, Rb1, Rc1, Rd13), (Ra5, Rb1, Rc1, Rd14) , (Ra5, Rb1, Rc1, Rd15), (Ra5, Rb1, Rc1, Rd16), (Ra5, Rb1, Rc1, Rd17), (Ra5, Rb1, Rc1, Rd18), (Ra5, Rb1, Rc1, Rd19) , (Ra5, Rb1, Rc1, Rd20), (Ra5, Rb1, Rc1, Rd21), (Ra5, Rb1, Rc1, Rd22), (Ra5, Rb1, Rc1, Rd23), (Ra5, Rb1, Rc1, Rd24) , (Ra5, Rb1, Rc1, Rd25), (Ra5, Rb1, Rc1, Rd26), (Ra5, Rb1, Rc1, Rd27), (Ra5, Rb1, Rc1, Rd28), (Ra5, Rb1, Rc1, Rd29) , (Ra5, Rb1, Rc2, 1Rd1), (Ra5, Rb1, Rc2, Rd2), (Ra5, Rb1, Rc2, Rd3), (Ra5, Rb1, Rc2, Rd4), (Ra5, Rb1, Rc2, Rd5) , (Ra5, Rb1, Rc2, Rd6), (Ra5, Rb1, Rc2, Rd7), (Ra5, Rb1, Rc2, Rd8), (Ra5, Rb1, Rc2, Rd9), (Ra5, Rb1, Rc2, Rd10) , (Ra5, Rb1, Rc2, Rd11), (Ra5, Rb1, Rc2, Rd12), (Ra5, Rb1, Rc2, Rd13), (Ra5, Rb1, Rc2, Rd14), (Ra5, Rb1, Rc2, Rd15), (Ra5, Rb1, Rc2, Rd16), (Ra5, Rb1, Rc2, Rd17), (Ra5, Rb1, Rc2, Rd18), (Ra5, Rb1, Rc2, Rd19), (Ra5, Rb1, Rc2, Rd20), (Ra5, Rb1, Rc2, Rd21), (Ra5, Rb1, Rc2, Rd22), (Ra5, Rb1, Rc2, Rd23), (Ra5, Rb1, Rc2, Rd24), (Ra5, Rb1, Rc2, Rd25), (Ra5, Rb1, Rc2, Rd26), (Ra5, Rb1, Rc2, Rd27), (Ra5, Rb1, Rc2, Rd28), (Ra5, Rb1, Rc2, Rd29), (Ra5, Rb1, Rc3, Rd1), (Ra5, Rb1, Rc3, Rd2), (Ra5, Rb1, Rc3, Rd3), (Ra5, Rb1, Rc3, Rd4), (Ra5, Rb1, Rc3, Rd5), (Ra5, Rb1, Rc3, Rd6), (Ra5, Rb1, Rc3, Rd7), (Ra5, Rb1, Rc3, Rd8), (Ra5, Rb1, Rc3, Rd9), (Ra5, Rb1, Rc3, Rd10), (Ra5, Rb1, Rc3, Rd11), (Ra5, Rb1, Rc3, Rd12), (Ra5, Rb1, Rc3, Rd13), (Ra5, Rb1, Rc3, Rd14), (Ra5, Rb1, Rc3, Rd15), (Ra5, Rb1, Rc3, Rd16), (Ra5, Rb1, Rc3, Rd17), (Ra5, Rb1, Rc3, Rd18), (Ra5, Rb1, Rc3, Rd19), (Ra5, Rb1, Rc3, Rd20), (Ra5, Rb1, Rc3, Rd2 (1), (Ra5, Rb1, Rc3, Rd22), (Ra5, Rb1, Rc3, Rd23), (Ra5, Rb1, Rc3, Rd24), (Ra5, Rb1, Rc3, Rd25), (Ra5, Rb1, Rc3, Rd26), (Ra5, Rb1, Rc3, Rd27), (Ra5, Rb1, Rc3, Rd28), (Ra5, Rb1, Rc3, Rd29), (Ra5, Rb1, Rc4, Rd1), (Ra5, Rb1, Rc4, Rd2), (Ra5, Rb1, Rc4, Rd3), (Ra5, Rb1, Rc4, Rd4), (Ra5, Rb1, Rc4, Rd5), (Ra5, Rb1, Rc4, Rd6), (Ra5, Rb1, Rc4, Rd7), (Ra5, Rb1, Rc4, Rd8), (Ra5, Rb1, Rc4, Rd9), (Ra5, Rb1, Rc4, Rd10), (Ra5, Rb1, Rc4, Rd11), (Ra5, Rb1, Rc4, Rd12), (Ra5, Rb1, Rc4, Rd13), (Ra5, Rb1, Rc4, Rd14), (Ra5, Rb1, Rc4, Rd15), (Ra5, Rb1, Rc4, Rd16), (Ra5, Rb1, Rc4, Rd17), (Ra5, Rb1, Rc4, Rd18), (Ra5, Rb1, Rc4, Rd19), (Ra5, Rb1, Rc4, Rd20), (Ra5, Rb1, Rc4, Rd21), (Ra5, Rb1, Rc4, Rd22), (Ra5, Rb1, Rc4, Rd23), (Ra5, Rb1, Rc4, Rd24), (Ra5, Rb1, Rc4, Rd25), (Ra5, Rb1, Rc4, Rd26), (Ra5, Rb1, Rc4, Rd27), (Ra5, Rb1, Rc4, Rd28), (Ra5, Rb1, Rc4, Rd29), (Ra5, Rb1, Rc5, Rd1), (Ra5, Rb1, Rc5, Rd2), (Ra5, Rb1, Rc5, Rd3), (Ra5, Rb1, Rc5, Rd4), (Ra5, Rb1, Rc5, Rd5), (Ra5, Rb1, Rc5, Rd6), (Ra5, Rb1, Rc5, Rd7), (Ra5, Rb1, Rc5, Rd8), (Ra5, Rb1, Rc5, Rd9), (Ra5, Rb1, Rc5, Rd10), (Ra5, Rb1, Rc5, Rd11), (Ra5, Rb1, Rc5, Rd12), (Ra5, Rb1, Rc5, Rd13), (Ra5, Rb1, Rc5, Rd14), (Ra5, Rb1, Rc5, Rd15), (Ra5, Rb1, Rc5, Rd16), (Ra5, Rb1, Rc5, Rd17), (Ra5, Rb1, Rc5, Rd18), (Ra5, Rb1, Rc5, Rd19), (Ra5, Rb1, Rc5, Rd20), (Ra5, Rb1, Rc5, Rd21), (Ra5, Rb1, Rc5, Rd22), (Ra5, Rb1, Rc5, Rd23), (Ra5, Rb1, Rc5, Rd24), (Ra5, Rb1, Rc5, Rd25), (Ra5, Rb1, Rc5, Rd26), (Ra5, Rb1, Rc5, Rd27), (Ra5, Rb1, Rc5, Rd28), (Ra5, Rb1, Rc5, Rd29), (Ra5, Rb2, Rc1, Rd1), (Ra5, Rb2, Rc1, Rd2), (Ra5, Rb2, Rc1, Rd3), (Ra5, Rb2, Rc1, Rd4), (Ra5, Rb2, Rc1, Rd5), (Ra5, Rb2, Rc1, Rd6), (Ra5, Rb2, Rc1, Rd7), (Ra5, Rb2, Rc1, Rd8), (Ra5, Rb2, Rc1, Rd9) , (Ra5, Rb2, Rc1, Rd10), (Ra5, Rb2, Rc1, Rd11), (Ra5, Rb2, Rc1, Rd12), (Ra5, Rb2, Rc1, Rd13), (Ra5, Rb2, Rc1, Rd14) , (Ra5, Rb2, Rc1, Rd15), (Ra5, Rb2, Rc1, Rd16), (Ra5, Rb2, Rc1, Rd17), (Ra5, Rb2, Rc1, Rd18), (Ra5, Rb2, Rc1, Rd19) , (Ra5, Rb2, Rc1, 20Rd20), (Ra5, Rb2, Rc1, Rd21), (Ra5, Rb2, Rc1, Rd22), (Ra5, Rb2, Rc1, Rd23), (Ra5, Rb2, Rc1, Rd24) , (Ra5, Rb2, cRc1, Rd25), (Ra5, Rb2, Rc1, Rd26), (Ra5, Rb2, Rc1, Rd27), (Ra5, Rb2, Rc1, Rd28), (Ra5, Rb2, Rc1, Rd29) , (Ra5, Rb2, Rc2, Rd1), (Ra5, Rb2, Rc2, Rd2), (Ra5, Rb2, Rc2, Rd3), (Ra5, Rb2, Rc2, Rd4), (Ra5, Rb2, Rc2, Rd5) , (Ra5, Rb2, Rc2, Rd6), (Ra5, Rb2, Rc2, Rd7), (Ra5, Rb2, Rc2, Rd8), (Ra5, Rb2, Rc2, Rd9), (Ra5, Rb2, Rc2, Rd10) , (Ra5, Rb2, Rc2, Rd11), (Ra5, Rb2, Rc2, Rd12), (Ra5, Rb2, Rc2, Rd13), (Ra5, Rb2, Rc2, Rd14), (Ra5, Rb2, Rc2, Rd15) , (Ra5, Rb2, Rc2, Rd16), (Ra5, Rb2, Rc2, Rd17), (Ra5, Rb2, Rc2, Rd18), (Ra5, Rb2, Rc2, Rd19), (Ra5, Rb2, Rc2, Rd20), (Ra5, Rb2, Rc2, Rd21), (Ra5, Rb2, Rc2, Rd22), (Ra5, Rb2, Rc2, Rd23), (Ra5, Rb2, Rc2, Rd24), (Ra5, Rb2, Rc2, Rd25), (Ra5, Rb2, Rc2, Rd26), (Ra5, Rb2, Rc2, Rd27), (Ra5, Rb2, Rc2, Rd28), (Ra5, Rb2, Rc2, Rd29), (Ra5, Rb2, Rc3, Rd1), (Ra5, Rb2, Rc3, Rd2), (Ra5, Rb2, Rc3, Rd3), (Ra5, Rb2, Rc3, Rd4), (Ra5, Rb2, Rc3, Rd5), (Ra5, Rb2, Rc3, Rd6), (Ra5, Rb2, Rc3, Rd7), (Ra5, Rb2, Rc3, Rd8), (Ra5, Rb2, Rc3, Rd9), (Ra5, Rb2, Rc3, Rd10), (Ra5, Rb2, Rc3, Rd11), (Ra5, Rb2, Rc3, Rd12), (Ra5, Rb2, Rc3, Rd13), (Ra5, Rb2, Rc3, Rd14), (Ra5, Rb2, Rc3, Rd15), (Ra5, Rb2, Rc3, Rd16), (Ra5, Rb2, Rc3, Rd17), (Ra5, Rb2, Rc3, Rd18), (Ra5, Rb2, Rc3, Rd19), (Ra5, Rb2, Rc3, Rd20), (Ra5, Rb2, Rc3, Rd21), (Ra5, Rb2, Rc3, Rd22), (Ra5, Rb2, Rc3, Rd23), (Ra5, Rb2, Rc3, Rd24), (Ra5, Rb2, Rc3, Rd25), (Ra5, Rb2, Rc3, Rd26), (Ra5, Rb2, Rc3, Rd27), (Ra5, Rb2, Rc3, Rd28), (Ra5, Rb2, Rc3, Rd29), (Ra5, Rb2, Rc4, Rd1), (Ra5, Rb2, Rc4, Rd2), (Ra5, Rb2, Rc4, Rd3), (Ra5, Rb2, Rc4, Rd4), (Ra5, Rb2, Rc4, Rd5), (Ra5, Rb2, Rc4, Rd6), (Ra5, Rb2, Rc4, Rd7), (Ra5, Rb2, Rc4, Rd8), (Ra5, Rb2, Rc4, Rd9), (Ra5, Rb2, Rc4, Rd10), (Ra5, Rb2, Rc4, Rd11), (Ra5, Rb2, Rc4, Rd12), (Ra5, Rb2, Rc4, Rd13), (Ra5, Rb2, Rc4, Rd14), (Ra5, Rb2, Rc4, Rd15), (Ra5, Rb2, Rc4, Rd16), (Ra5, Rb2, Rc4, Rd17), (Ra5, Rb2, Rc4, Rd18), (Ra5, Rb2, Rc4, Rd19), (Ra5, Rb2, Rc4, Rd20), (Ra5, Rb2, Rc4, Rd21), (Ra5, Rb2, Rc4, Rd22), (Ra5, Rb2, Rc4, Rd23), (Ra5, Rb2, Rc4, Rd24), (Ra5, Rb2, Rc4, Rd25), (Ra5, Rb2, Rc4, Rd26), (Ra5, Rb2, Rc4, Rd27), (Ra5, Rb2, Rc4, Rd28), (Ra5, Rb2, Rc4, Rd29), (Ra5, Rb2, Rc5, Rd1), (Ra5, Rb2, Rc5, Rd2), (Ra5, Rb2, Rc5, Rd3), (Ra5, Rb2, Rc5, Rd4), (Ra5, Rb2, Rc5, Rd5), (Ra5, Rb2, Rc5, Rd6), (Ra5, Rb2, Rc5, Rd7), (Ra5, Rb2, Rc5, Rd8), (Ra5, Rb2, Rc5, Rd9), (Ra5, Rb2, Rc5, Rd10), (Ra5, Rb2, Rc5, Rd11), (Ra5, Rb2, Rc5, Rd12), (Ra5, Rb2, Rc5, Rd13),

(Ra5, Rb2, Rc5, Rd14), (Ra5, Rb2, Rc5, Rd15), (Ra5, Rb2, Rc5, Rd16), (Ra5, Rb2, Rc5, Rd17), (Ra5, Rb2, dRc5, Rd18), (Ra5, Rb2, Rc5, Rd19), (Ra5, Rb2, Rc5, Rd20), (Ra5, Rb2,5Rc5, Rd21), (Ra5, Rb2, Rc5, Rd22), (Ra5, Rb2, Rc5, Rd23), (Ra5, Rb2, Rc5, Rd24), (Ra5, Rb2, Rc5, Rd25), (Ra5, Rb2, Rc5, Rd26), (Ra5, Rb2, 、 Rc5, Rd27), (Ra5, Rb2, Rc5, Rd28), (Ra5, Rb2, Rc5, Rd29), (Ra6, Rb1, Rc1, Rd1), (Ra6, Rb1, Rc1, Rd2), (Ra6, Rb1, Rc1, Rd3), (Ra6, Rb1, Rc1, Rd4), (Ra6, Rb1, Rc1, Rd5), (Ra6, Rb1, Rc1, Rd7), (Ra6, Rb1, Rc1, Rd8), (Ra6, Rb1, Rc1, Rd9), (Ra6, Rb1, Rc1, Rd10), (Ra6, Rb1, Rc1, Rd12), (Ra6, Rb1, Rc1, Rd13), (Ra6, Rb1, Rc1, Rd14), (Ra6, Rb1, Rc1, Rd15), (Ra6, Rb1, Rc1, Rd17), (Ra6, Rb1, Rc1, Rd18), (Ra6, Rb1, Rc1, Rd19), (Ra6, Rb1, Rc1, Rd20), (Ra6, Rb1, Rc1, Rd21), (Ra6, R b1, Rc1, Rd22), (Ra6, Rb1, Rc1, Rd23), (Ra6, Rb1, Rc1, Rd24), (Ra6, Rb1, Rc1, Rd25), (Ra6, Rb1, Rc1, Rd26), (Ra6, Rb1, Rc1, Rd27), (Ra6, Rb1, Rc1, Rd28), (Ra6, Rb1, Rc1, Rd29), (Ra6, Rb1, Rc2, Rd1), (Ra6, Rb1, Rc2, Rd2), (Ra6, Rb1, Rc2, Rd3), (Ra6, Rb1, Rc2, Rd4), (Ra6, Rb1, Rc2, Rd5), (Ra6, Rb1, Rc2, Rd6), (Ra6, Rb1, Rc2, Rd7), (Ra6, Rb1, Rc2, Rd8), (Ra6, Rb1, Rc2, Rd9), (Ra6, Rb1, Rc2, Rd10), (Ra6, Rb1, Rc2, Rd11), (Ra6, Rb1, Rc2, Rd12), (Ra6, Rb1, Rc2, Rd13), (Ra6, Rb1, Rc2, Rd14), (Ra6, Rb1, Rc2, Rd15), (Ra6, Rb1, Rc2, Rd16), (Ra6, Rb1, Rc2, Rd17), (Ra6, Rb1, Rc2, Rd18), (Ra6, Rb1, Rc2, Rd19), (Ra6, Rb1, Rc2, Rd20), (Ra6, Rb1, Rc2, Rd21), (Ra6, Rb1, Rc2, Rd22), (Ra6, Rb1, Rc2, Rd23), (Ra6, Rb1, Rc2, Rd24), (Ra6, Rb1, Rc2, Rd25), (Ra6, Rb1, Rc2, Rd26), (Ra6, Rb1, Rc2, Rd27), (Ra6, Rb1, Rc2, Rd28), (Ra6, Rb1, Rc2, Rd29), (Ra6, Rb1, Rc3, Rd1), (Ra6, Rb1, Rc3, Rd2), (Ra6, Rb1, Rc3, Rd3), (Ra6, Rb1, Rc3, Rd4), (Ra6, Rb1, Rc3, Rd5), (Ra6, Rb1, Rc3, Rd6), (Ra6, Rb1, Rc3, Rd7), (Ra6, Rb1, Rc3, Rd8), (Ra6, Rb1, Rc3, Rd9), (Ra6, Rb1, Rc3, Rd10), (Ra6, Rb1, Rc3, Rd11), (Ra6, Rb1, Rc3, Rd12), (Ra6, Rb1, Rc3, Rd13), (Ra6, Rb1, Rc3, Rd14), (Ra6, Rb1, Rc3, Rd15), (Ra6, Rb1, Rc3, Rd16), (Ra6, Rb1, Rc3, Rd17), (Ra6, Rb1, Rc3, Rd18), (Ra6, Rb1, Rc3, Rd19), (Ra6, Rb1, Rc3, Rd20), (Ra6, Rb1, Rc3, Rd21), (Ra6, Rb1, Rc3, Rd22), (Ra6, Rb1, Rc3, Rd23), (Ra6, Rb1, Rc3, Rd24), (Ra6, Rb1, Rc3, Rd25), (Ra6, Rb1, Rc3, Rd26), (Ra6, Rb1, Rc3, Rd27), (Ra6, Rb1, Rc3, Rd28), (Ra6, Rb1, Rc3, Rd29), (Ra6, Rb1, Rc4, Rd1), (Ra6, Rb1, Rc4, Rd2), (Ra6, Rb1, Rc4, Rd3), (Ra6, Rb1, Rc4, Rd4), (Ra6, Rb1, Rc4, Rd5), (Ra6, Rb1, Rc4, Rd6), (Ra6, Rb1, Rc4, Rd7), (Ra6, Rb1, Rc4, Rd8), (Ra6, Rb1, Rc4, Rd9), (Ra6, Rb1 , Rc4, Rd10), (Ra6, Rb1, Rc4, Rd11), (Ra6, Rb1, Rc4, Rd12), (Ra6, Rb1, Rc4, Rd13), (Ra6, Rb1, Rc4, Rd14), (Ra6, Rb1) , Rc4, Rd15), (Ra6, Rb1, Rc4, Rd16), (Ra6, Rb1, Rc4, Rd17), (Ra6, Rb1, Rc4, Rd18), (Ra6, Rb1, Rc4, Rd19), (Ra6, Rb1) , Rc4, Rd20), (Ra6, Rb1, Rc4, Rd21), (Ra6, Rb1, Rc4, Rd22), (Ra6, Rb1, Rc4, Rd23), (Ra6, Rb1, Rc4, Rd24), (Ra6, Rb1) , Rc4, Rd25), (Ra6, Rb1, Rc4, Rd26), (Ra6, Rb1, Rc4, Rd27), (Ra6, Rb1, Rc4, Rd28), (Ra6, Rb1, Rc4, Rd29), (Ra6, Rb1) , Rc5, Rd1), (Ra6, Rb1, Rc5, Rd2), (Ra6, Rb1, Rc5, Rd3), (Ra6, Rb1, Rc5, Rd4), (Ra6, Rb1, Rc5, Rd5), (Ra6, Rb1) , Rc5, Rd6), (Ra6,6Rb1, Rc5, Rd7), (Ra6, Rb1, Rc5, Rd8), (Ra6, Rb1, Rc5, Rd9), (Ra6, Rb1, Rc5, Rd10), (Ra6, Rb1) , Rc5, Rd11), (Ra6, Rb1, Rc5, Rd12), (Ra6, Rb1, Rc5, Rd13), (Ra6, Rb1, Rc5, Rd14), (Ra6, Rb1, Rc5, Rd15), (Ra6, Rb1) , Rc5, Rd16), (Ra6, Rb1, Rc5, Rd17), (Ra6, Rb1, Rc5, R d18), (Ra6, Rb1, Rc5, Rd19), (Ra6, Rb1, Rc5, Rd20), (Ra6, Rb1, Rc5, Rd21), (Ra6, Rb1, Rc5, Rd22), (Ra6, Rb1, Rc5, Rd23), (Ra6, Rb1, Rc5, Rd24), (Ra6, Rb1, Rc5, Rd25), (Ra6, Rb1, Rc5, Rd26), (Ra6, Rb1, Rc5, Rd27), (Ra6, Rb1, Rc5, Rd28), (Ra6, Rb1, Rc5, Rd29), (Ra6, Rb2, Rc1, Rd1), (Ra6, Rb2, Rc1, Rd2), (Ra6, Rb2, Rc1, Rd3), (Ra6, Rb2, Rc1, Rd4), (Ra6, Rb2, Rc1, Rd5), (Ra6, Rb2, Rc1, Rd6), (Ra6, Rb2, Rc1, Rd7), (Ra6, Rb2, Rc1, Rd8), (Ra6, Rb2, Rc1, Rd9), (Ra6, Rb2, Rc1, Rd10), (Ra6, Rb2, Rc1, Rd11), (Ra6, Rb2, Rc1, Rd12), (Ra6, Rb2, Rc1, Rd13), (Ra6, Rb2, Rc1, Rd14), (Ra6, Rb2, Rc1, Rd15), (Ra6, Rb2, Rc1, Rd16), (Ra6, Rb2, Rc1, Rd17), (Ra6, Rb2, Rc1, Rd18), (Ra6, Rb2, Rc1, Rd19), (Ra6, Rb2, Rc1, Rd20), (Ra6, Rb2, Rc1, Rd21), (Ra6, Rb2, Rc1, Rd22), (Ra6, Rb2, Rc1, Rd23), (Ra6, Rb2, Rc1, Rd24), (Ra6, Rb2, Rc1, Rd25), (Ra6, Rb2, Rc1, Rd26), (Ra 6, Rb2, Rc1, Rd27), (Ra6, Rb2, Rc1, Rd28), (Ra6, Rb2, Rc1, Rd29), (Ra6, Rb2, Rc2, Rd1), (Ra6, Rb2, Rc2, Rd2), ( Ra6, Rb2, Rc2, Rd3), (Ra6, Rb2, Rc2,) Rd4), (Ra6, Rb2, Rc2, Rd5), (Ra6, Rb2, Rc2, Rd6), (Ra6, Rb2, Rc2, Rd7), ( (Ra6, Rb2, Rc2, Rd8), (Ra6, Rb2, Rc2, Rd9), (Ra6, Rb2, Rc2, Rd10), (Ra6, Rb2, Rc2, Rd11), (Ra6, Rb2, Rc2, Rd12), ( Ra6, Rb2, Rc2, Rd13), (Ra6, Rb2, Rc2, (Rd14), (Ra6, Rb2, 16Rc2, Rd15), (Ra6, Rb2, Rc2, Rd16), (Ra6, Rb2, Rc2, Rd17), ( Ra6, Rb2, Rc2, Rd18), (Ra6, Rb2, Rc2, 、 Rd19), (Ra6, Rb2, Rc2, Rd20), (Ra6, Rb2, Rc2, Rd21), (Ra6, Rb2, Rc2, Rd22), ( Ra6, Rb2, Rc2, Rd23), (Ra6, Rb2, Rc2, Rd24), (Ra6, Rb2, Rc2, Rd25), (Ra6, Rb2, Rc2, Rd26), (Ra6, Rb2, Rc2, Rd27), ( (Ra6, Rb2, Rc2, 28Rd28), (Ra6, Rb2, Rc2, Rd29), (Ra6, Rb2, Rc3, Rd1), (Ra6, Rb2, Rc3, Rd2), (Ra6, Rb2, Rc3, Rd3), Ra6, Rb2, Rc3, Rd4), (Ra6, Rb2, Rc3, Rd5), (Ra6, Rb2, Rc3, Rd6), (Ra6, Rb2, Rc3, Rd7), (Ra6, Rb2, Rc3, Rd8), (Ra6, Rb2, Rc3, Rd9), (Ra6, Rb2, Rc3, Rd10), (Ra6, Rb2, Rc3, Rd11), (Ra6, Rb2, Rc3, Rd12), (Ra6, Rb2, Rc3, Rd13), (Ra6, Rb2, Rc3, Rd14), (Ra6, Rb2, Rc3, Rd15), (Ra6, Rb2, Rc3, Rd16), (Ra6, Rb2, Rc3, Rd17), (Ra6, Rb2, Rc3, Rd18), (Ra6, Rb2, Rc3, Rd19), (Ra6, Rb2, Rc3, Rd20), (Ra6, Rb2, Rc3, Rd21), (Ra6, Rb2, Rc3, Rd22), (Ra6, Rb2, Rc3, Rd23), (Ra6, Rb2, Rc3, Rd24), (Ra6, Rb2, Rc3, Rd25),

(Ra6, Rb2, Rc3, Rd26), (Ra6, Rb2, Rc3, Rd27), (Ra6, Rb2, Rc3, Rd28), (Ra6, Rb2, Rc3, Rd29), (Ra6, Rb2, Rc4, Rd1), (Ra6, Rb2, Rc4, Rd2), (Ra6, Rb2, Rc4, Rd3), (Ra6, Rb2, Rc4, Rd4), (Ra6, Rb2, 、 Rc4, Rd5), (Ra6, Rb2, Rc4, Rd6), (Ra6, Rb2, Rc4, Rd7), (Ra6, Rb2, Rc4, Rd8), (Ra6, Rb2, Rc4, Rd9), (Ra6, Rb2, Rc4, Rd10), (Ra6, Rb2, Rc4, Rd11), (Ra6, Rb2, Rc4, Rd12), (Ra6, Rb2, Rc4, Rd13), (Ra6, Rb2, Rc4, Rd14), (Ra6, Rb2, Rc4, Rd15), (Ra6, Rb2, Rc4, Rd16), (Ra6, Rb2, Rc4, Rd17), (Ra6, Rb2, Rc4, Rd18), (Ra6, Rb2, Rc4, Rd19), (Ra6, Rb2, Rc4, Rd20), (Ra6, Rb2, Rc4, Rd21), (Ra6, Rb2, Rc4, Rd22), (Ra6, Rb2, Rc4, Rd23), (Ra6, Rb2, Rc4, Rd24), (Ra6, Rb2, Rc4, Rd25), (Ra6, Rb2, Rc4, Rd26), (Ra6, Rb2, Rc4, Rd27), (Ra6, Rb2, Rc4, Rd28), (Ra6, Rb2, Rc4, Rd29), (Ra6, Rb2, Rc5, Rd1), (Ra6, Rb2, Rc5, Rd2), (Ra6, Rb2, Rc5, Rd3), (Ra6, Rb2, Rc5, Rd4), (Ra6, Rb2, Rc5, Rd5), (Ra6, Rb2, Rc5, Rd6), (Ra6, Rb2, Rc5, Rd7), (Ra6, Rb2, Rc5, Rd8), (Ra6, Rb2, Rc5, Rd9), (Ra6, Rb2, Rc5, Rd10), (Ra6, Rb2, Rc5, Rd11), (Ra6, Rb2, Rc5, Rd12), (Ra6, Rb2, Rc5, Rd13), (Ra6, Rb2, Rc5, Rd14), (Ra6, Rb2, Rc5, Rd15), (Ra6, Rb2, Rc5, Rd16), (Ra6, Rb2, Rc5, Rd17), (Ra6, Rb2, Rc5, Rd18), (Ra6, Rb2, Rc5, Rd19), (Ra6, Rb2, Rc5, Rd20), (Ra6, Rb2, Rc5, Rd21), (Ra6, Rb2, Rc5, Rd22), (Ra6, Rb2, Rc5, Rd23), (Ra6, Rb2, Rc5, Rd24), (Ra6, Rb2, Rc5, Rd25), (Ra6, Rb2, Rc5, Rd26), (Ra6, Rb2, Rc5, Rd27), (Ra6, Rb2, Rc5, Rd28), (Ra6, Rb2, Rc5, Rd29), (Ra7, Rb1, Rc1, Rd1), (Ra7, Rb1, Rc1, Rd2), (Ra7, Rb1, Rc1, Rd3), (Ra7, Rb1, Rc1, Rd4), (Ra7, Rb1, Rc1, Rd5), (Ra7, Rb1, Rc1, Rd6), (Ra7, Rb1, Rc1, Rd7), (Ra7, Rb1, Rc1, Rd8), (Ra7, Rb1, Rc1, Rd9), (Ra7, Rb1, Rc1, Rd10), (Ra7, Rb1, Rc1, Rd11), (Ra7, Rb1, Rc1, Rd12), (Ra7, Rb1, Rc1, Rd13), (Ra7, Rb1, Rc1, Rd14), (Ra7, Rb1, Rc1, Rd16), (Ra7, Rb1, Rc1, Rd17), (Ra7, Rb1, Rc1, Rd18), (Ra7, Rb1, Rc1, Rd19), (Ra7, Rb1, Rc1, Rd21), (Ra7, Rb1, Rc1, Rd22), (Ra7, Rb1, Rc1, Rd23), (Ra7, Rb1, Rc1, Rd24), (Ra7, Rb1, Rc1, Rd26), (Ra7, Rb1, Rc1, Rd27), (Ra7, Rb1, Rc1, Rd28), (Ra7, Rb1, Rc1, 29Rd29), (Ra7, Rb1, Rc2, (Rd2), (Ra7, Rb1, Rc2, Rd3), (Ra7, Rb1, Rc2, Rd4), (Ra7, Rb1, Rc2, Rd5), (Ra7, Rb1, Rc2, (Rd6), (Ra7, Rb1, Rc2, Rd7), (Ra7, Rb1, Rc2, Rd8), (Ra7, Rb1, Rc2, Rd9), (Ra7, Rb1, Rc2, Rd10), (Ra7, Rb1, Rc2, Rd11), (Ra7, Rb1, Rc2, Rd12), (Ra7, Rb1, Rc2, Rd13), (Ra7, Rb1, Rc2, Rd14), (Ra7, Rb1, Rc2, Rd15), (Ra7, Rb1, Rc2, (Rd17), (Ra7, Rb1, Rc2, Rd18), (Ra7, Rb1, Rc2, Rd19), (Ra7, Rb1, Rc2, Rd20), (Ra7, Rb1, Rc2, Rd21), (Ra7, Rb1 , Rc2, Rd22), (Ra7, Rb1, Rc2, Rd24), (Ra7, Rb1, Rc2, Rd25), (Ra7, Rb1, Rc2, Rd26), (Ra7, Rb1) , Rc2, Rd27), (Ra7, Rb1, Rc2, Rd28), (Ra7, Rb1, Rc2, Rd29), (Ra7, Rb1, Rc3, Rd1), (Ra7, Rb1, Rc3, Rd2), (Ra7, Rb1) , Rc3, Rd3), (Ra7, Rb1, Rc3, Rd4), (Ra7, Rb1, Rc3, Rd5), (Ra7, Rb1, Rc3, Rd6), (Ra7, Rb1, Rc3, Rd7), (Ra7, Rb1) , Rc3, Rd8), (Ra7, Rb1, Rc3, Rd10), (Ra7, Rb1, Rc3, Rd11), (Ra7, Rb1, Rc3, Rd12), (Ra7, Rb1) , Rc3, Rd13), (Ra7, Rb1, Rc3, Rd15), (Ra7, Rb1, Rc3, Rd16), (Ra7, Rb1, Rc3, Rd17), (Ra7, Rb1) , Rc3, dRd18), (Ra7, Rb1, Rc3, Rd19), (Ra7, Rb1, Rc3, Rd20), (Ra7, Rb1, Rc3, Rd21), (Ra7, Rb1, Rc3, Rd22), (Ra7, Rb1) , Rc3, Rd23), (Ra7, Rb1, Rc3, Rd24), (Ra7, Rb1, Rc3, Rd25), (Ra7, Rb1, Rc3, Rd26), (Ra7, Rb1, Rc3, Rd27), (Ra7, Rb1) , Rc3, Rd28), (Ra7,7Rb1, Rc3, Rd29), (Ra7, Rb1, Rc4, R d1), (Ra7, Rb1, Rc4, Rd2), (Ra7, Rb1, Rc4, Rd3), (Ra7, Rb1, Rc4, Rd4), (Ra7, Rb1, Rc4, Rd5), (Ra7, Rb1, Rc4, Rd6), (Ra7, Rb1, Rc4, Rd7), (Ra7, Rb1, Rc4, Rd8), (Ra7, Rb1, Rc4, Rd9), (Ra7, Rb1, Rc4, Rd10), (Ra7, Rb1, Rc4, Rd11), (Ra7, Rb1, Rc4, Rd12), (Ra7, Rb1, Rc4, Rd13), (Ra7, Rb1, Rc4, Rd14), (Ra7, Rb1, Rc4, Rd15), (Ra7, Rb1, Rc4, Rd16), (Ra7, Rb1, Rc4, Rd17), (Ra7, Rb1, Rc4, Rd18), (Ra7, Rb1, Rc4, Rd19), (Ra7, Rb1, Rc4, Rd20), (Ra7, Rb1, Rc4, Rd21), (Ra7, Rb1, Rc4, Rd22), (Ra7, Rb1, Rc4, Rd23), (Ra7, Rb1, Rc4, Rd24), (Ra7, Rb1, Rc4, Rd25), (Ra7, Rb1, Rc4, Rd26), (Ra7, Rb1, Rc4, Rd27), (Ra7, Rb1, Rc4, Rd28), (Ra7, Rb1, Rc4, Rd29), (Ra7, Rb1, Rc5, Rd1), (Ra7, Rb1, Rc5, Rd2), (Ra7, Rb1, Rc5, Rd3), (Ra7, Rb1, Rc5, Rd4), (Ra7, Rb1, Rc5, Rd5), (Ra7, Rb1, Rc5, Rd6), (Ra7, Rb1, Rc5, Rd7), (Ra7, Rb1, Rc5, Rd8), (Ra7, Rb1, Rc5, Rd9), (Ra7, Rb1, Rc5, Rd10), (Ra7, Rb1, Rc5, Rd11), (Ra7, Rb1, Rc5, Rd12), (Ra7, Rb1, Rc5, Rd13), (Ra7, Rb1, Rc5, Rd14), (Ra7, Rb1, Rc5, Rd15), (Ra7, Rb1, Rc5, Rd16), (Ra7, Rb1, Rc5, Rd17), (Ra7, Rb1, Rc5, Rd18), (Ra7, Rb1, Rc5, Rd19), (Ra7, Rb1, Rc5, Rd20), (Ra7, Rb1, Rc5, Rd21), (Ra7, Rb1, Rc5, Rd22), (Ra7, Rb1, Rc5, Rd23), (Ra7, Rb1, Rc5, Rd24), (Ra7, Rb1, Rc5, Rd25), (Ra7, Rb1, Rc5, Rd26), (Ra7, Rb1, Rc5, Rd27), (Ra7, Rb1, Rc5, Rd28), (Ra7, Rb1, Rc5, Rd29), (Ra7, Rb2, Rc1, Rd1), (Ra7, Rb2, Rc1, Rd2), (Ra7, Rb2, Rc1, Rd3), (Ra7, Rb2, Rc1, Rd4), (Ra7, Rb2, Rc1, Rd5), (Ra7, Rb2, Rc1, Rd6), (Ra7, Rb2, Rc1, Rd7), (Ra7, Rb2, Rc1, Rd8), (Ra7, Rb2, Rc1, Rd9), (Ra7, Rb2, Rc1, Rd10), (Ra7, Rb2, Rc1, Rd11), (Ra7, Rb2, Rc1, Rd12), (Ra7, Rb2, Rc1, Rd13), (Ra7, Rb2, Rc1, Rd14), (Ra7, Rb2, Rc1, Rd15), (Ra7, Rb2, Rc1, Rd16), (Ra7, Rb2, Rc1, Rd17), (Ra7, Rb2, Rc1, Rd1 8), (Ra7, Rb2, Rc1, Rd19), (Ra7, Rb2, Rc1, Rd20), (Ra7, Rb2, Rc1, Rd21), (Ra7, Rb2, Rc1, Rd22), (Ra7, Rb2, Rc1, Rd23), (Ra7, Rb2, Rc1, Rd24), (Ra7, Rb2, Rc1, Rd25), (Ra7, Rb2, Rc1, Rd26), (Ra7, Rb2, Rc1, Rd27), (Ra7, Rb2, Rc1, Rd28), (Ra7, Rb2, Rc1, Rd29), (Ra7, Rb2, Rc2, Rd1), (Ra7, Rb2, Rc2, Rd2), (Ra7, Rb2, Rc2, Rd3), (Ra7, Rb2, Rc2, Rd4), (Ra7, Rb2, Rc2, Rd5), (Ra7, Rb2, Rc2, Rd6), (Ra7, Rb2, Rc2, Rd7), (Ra7, Rb2, Rc2, Rd8), (Ra7, Rb2, Rc2, Rd9), (Ra7, Rb2, Rc2, Rd10), (Ra7, Rb2, Rc2, Rd11), (Ra7, Rb2, Rc2, Rd12), (Ra7, Rb2, Rc2, Rd13), (Ra7, Rb2, Rc2, Rd14), (Ra7, Rb2, Rc2, Rd15), (Ra7, Rb2, Rc2, Rd16), (Ra7, Rb2, Rc2, Rd17), (Ra7, Rb2, Rc2, Rd18), (Ra7, Rb2, Rc2, Rd19), (Ra7, Rb2, Rc2, Rd20), (Ra7, Rb2, Rc2, Rd21), (Ra7, Rb2, Rc2, Rd22), (Ra7, Rb2, Rc2, Rd23), (Ra7, Rb2, Rc2, Rd24), (Ra7, Rb2, Rc2, Rd25), (Ra7, Rb2, Rc2, Rd26), (Ra7, Rb2, Rc2, Rd27), (Ra7, Rb2, Rc2, Rd28), (Ra7, Rb2, Rc2, Rd29), (Ra7, Rb2, Rc3, Rd1), (Ra7, Rb2, Rc3, Rd2), (Ra7, Rb2, Rc3, Rd3), (Ra7, Rb2, Rc3, Rd4), (Ra7, Rb2, Rc3, Rd5), (Ra7, Rb2, Rc3, Rd6), (Ra7, Rb2, Rc3, Rd7), (Ra7, Rb2, Rc3, Rd8), (Ra7, Rb2, Rc3, Rd9), (Ra7, Rb2, Rc3, Rd10),

(Ra7, Rb2, Rc3, Rd11), (Ra7, Rb2, Rc3, Rd12), (Ra7, Rb2, Rc3, Rd13), (Ra7, Rb2, Rc3, Rd14), (Ra7, Rb2, Rc3, Rd15), (Ra7, Rb2, Rc3, Rd16), (Ra7, Rb2, Rc3, Rd17), (Ra7, Rb2, Rc3, Rd18), (Ra7, Rb2, Rc3, Rd19), (Ra7, Rb2, Rc3, Rd20), (Ra7, Rb2, Rc3, Rd21), (Ra7, Rb2, Rc3, Rd22), (Ra7, Rb2, Rc3, Rd23), (Ra7, Rb2, Rc3, Rd24), (Ra7, Rb2, Rc3, Rd25), (Ra7, Rb2, Rc3, Rd26), (Ra7, Rb2, Rc3, Rd27), (Ra7, Rb2, Rc3, Rd28), (Ra7, Rb2, 、 Rc3, Rd29), (Ra7, Rb2, Rc4, Rd1), (Ra7, Rb2, Rc4, Rd2), (Ra7, Rb2, Rc4, Rd3), (Ra7, Rb2, Rc4, Rd4), (Ra7, Rb2, Rc4, Rd5), (Ra7, Rb2, Rc4, Rd6), (Ra7, Rb2, Rc4, Rd7), (Ra7, Rb2, Rc4, (Rd8), (Ra7, Rb2, Rc4, Rd9), (Ra7, Rb2, Rc4, Rd10), (Ra7, Rb2, Rc4, Rd11), (Ra7, Rb2, Rc4, Rd12), (Ra7, Rb2, Rc4, Rd13), (Ra7, Rb2, Rc4, Rd14), (Ra7, Rb2, Rc4, Rd15), (Ra7, Rb2, Rc4, Rd16), (Ra7, Rb2, Rc4, Rd17), (Ra7, Rb2, Rc4, Rd18), (Ra7, R b2, Rc4, Rd19), (Ra7, Rb2, Rc4, Rd20), (Ra7, Rb2, Rc4, Rd21), (Ra7, Rb2, Rc4, Rd22), (Ra7, Rb2, Rc4, Rd23), (Ra7, Rb2, Rc4, Rd24), (Ra7, Rb2, Rc4, Rd25), (Ra7, Rb2, Rc4, Rd26), (Ra7, Rb2, Rc4, Rd27), (Ra7, Rb2, Rc4, Rd28), (Ra7, Rb2, Rc4, Rd29), (Ra7, Rb2, Rc5, Rd1), (Ra7, Rb2, Rc5, Rd2), (Ra7, Rb2, Rc5, Rd3), (Ra7, Rb2, Rc5, Rd4), (Ra7, Rb2, Rc5, Rd5), (Ra7, Rb2, Rc5, Rd6), (Ra7, Rb2, Rc5, Rd7), (Ra7, Rb2, Rc5, Rd8), (Ra7, Rb2, Rc5, Rd9), (Ra7, Rb2, Rc5, Rd10), (Ra7, Rb2, Rc5, Rd11), (Ra7, Rb2, Rc5, Rd12), (Ra7, Rb2, Rc5, Rd13), (Ra7, Rb2, Rc5, Rd14), (Ra7, Rb2, Rc5, Rd15), (Ra7, Rb2, Rc5, Rd16), (Ra7, Rb2, Rc5, Rd17), (Ra7, Rb2, Rc5, Rd18), (Ra7, Rb2, Rc5, Rd19), (Ra7, Rb2, Rc5, Rd20), (Ra7, Rb2, Rc5, Rd21), (Ra7, Rb2, Rc5, Rd22), (Ra7, Rb2, Rc5, Rd23), (Ra7, Rb2, Rc5, Rd24), (Ra7, Rb2, Rc5, Rd25), (Ra7, Rb2, Rc5, Rd26), (Ra7, Rb2, Rc5, Rd27), (Ra7, Rb2, Rc5, Rd28), (Ra7, Rb2, Rc5, Rd29), (Ra8, Rb1, Rc1, Rd1), (Ra8, Rb1, Rc1, Rd2), (Ra8, Rb1, Rc1, Rd3), (Ra8, Rb1, Rc1, Rd4), (Ra8, Rb1, Rc1, Rd5), (Ra8, Rb1, Rc1, Rd6), (Ra8, Rb1, Rc1, Rd7), (Ra8, Rb1, Rc1, Rd8), (Ra8, Rb1, Rc1, Rd9), (Ra8, Rb1, Rc1, Rd10), (Ra8, Rb1, Rc1, Rd11), (Ra8, Rb1, Rc1, Rd12), (Ra8, Rb1, Rc1, Rd13), (Ra8, Rb1, Rc1, Rd14), (Ra8, Rb1, Rc1, Rd15), (Ra8, Rb1, Rc1, Rd16), (Ra8, Rb1, Rc1, Rd17), (Ra8, Rb1, Rc1, Rd18), (Ra8, Rb1, Rc1, Rd19), (Ra8, Rb1, Rc1, Rd20), (Ra8, Rb1, Rc1, Rd21), (Ra8, Rb1, Rc1, Rd22), (Ra8, Rb1, Rc1, Rd23), (Ra8, Rb1, Rc1, Rd24), (Ra8, Rb1, Rc1, Rd25), (Ra8, Rb1, Rc1, Rd26), (Ra8, Rb1, Rc1, Rd27), (Ra8, Rb1, Rc1, Rd28), (Ra8, Rb1, Rc1, Rd29), (Ra8, Rb1, Rc2, Rd1), (Ra8, Rb1, Rc2, Rd2), (Ra8, Rb1, Rc2, Rd3), (Ra8, Rb1, Rc2, Rd4), (Ra8, Rb1, Rc2, Rd5), (Ra8, Rb1, Rc2, Rd6), (Ra8, Rb1, Rc2, Rd7), (Ra8, Rb1, Rc2, Rd8), (Ra8, Rb1, Rc2, Rd9), (Ra8, Rb1, Rc2, Rd10), (Ra8, Rb1, Rc2, Rd11), (Ra8, Rb1, Rc2, Rd12), (Ra8, Rb1, Rc2, Rd13), (Ra8, Rb1, Rc2, Rd14), (Ra8, Rb1, Rc2, Rd15), (Ra8, Rb1, Rc2, Rd16), (Ra8, Rb1, Rc2, Rd17), (Ra8, Rb1, Rc2, Rd18), (Ra8, Rb1, Rc2, Rd19), (Ra8, Rb1, Rc2, Rd20), (Ra8, Rb1, Rc2, Rd21), (Ra8, Rb1, Rc2, Rd22), (Ra8, Rb1, Rc2, Rd23), (Ra8, Rb1, Rc2, Rd25), (Ra8, Rb1, Rc2, Rd25), (Ra8, Rb1, Rc2, Rd26), (Ra8, Rb1, Rc2, Rd27), (Ra8, Rb1, Rc2, Rd28), (Ra8, Rb1, Rc2, Rd29), (Ra8, Rb1, Rc3, Rd1), (Ra8, Rb1, Rc3, Rd2), (Ra8, Rb1, Rc3, Rd3), (Ra8, Rb1, Rc3, Rd4), (Ra8, Rb1, Rc3, Rd5), (Ra8, Rb1, Rc3, Rd6), (Ra8, Rb1, Rc3, Rd7), (Ra8, Rb1, Rc3, Rd8), (Ra8, Rb1, Rc3, Rd9), (Ra8, Rb1, Rc3, Rd10), (Ra8, Rb1, Rc3, Rd11), (Ra8, Rb1, Rc3, Rd12), (Ra8, Rb1, Rc3, Rd13), (Ra8, Rb1, Rc3, Rd14), (Ra8, Rb1, Rc3, R d15), (Ra8, Rb1, Rc3, Rd16), (Ra8, Rb1, Rc3, Rd17), (Ra8, Rb1, Rc3, Rd18), (Ra8, Rb1, Rc3, Rd19), (Ra8, Rb1, Rc3, Rd20), (Ra8, Rb1, Rc3, Rd21), (Ra8, Rb1, Rc3, Rd22), (Ra8, Rb1, Rc3, Rd23), (Ra8, Rb1, Rc3, Rd24), (Ra8, Rb1, Rc3, Rd25), (Ra8, Rb1, Rc3, Rd26), (Ra8, Rb1, Rc3, Rd27), (Ra8, Rb1, Rc3, Rd28), (Ra8, Rb1, Rc3, Rd29), (Ra8, Rb1, Rc4, Rd1), (Ra8, Rb1, Rc4, Rd2), (Ra8, Rb1, Rc4, Rd3), (Ra8, Rb1, Rc4, Rd4), (Ra8, Rb1, Rc4, Rd5), (Ra8, Rb1, Rc4, Rd6), (Ra8, Rb1, Rc4, Rd7), (Ra8, Rb1, Rc4, Rd8), (Ra8, Rb1, Rc4, Rd9), (Ra8, Rb1, Rc4, Rd10), (Ra8, Rb1, Rc4, Rd11), (Ra8, Rb1, Rc4, Rd12), (Ra8, Rb1, Rc4, Rd13), (Ra8, Rb1, Rc4, Rd14), (Ra8, Rb1, Rc4, Rd15), (Ra8, Rb1, Rc4, Rd16), (Ra8, Rb1, Rc4, Rd17), (Ra8, Rb1, Rc4, Rd18), (Ra8, Rb1, Rc4, Rd19), (Ra8, Rb1, Rc4, Rd20), (Ra8, Rb1, Rc4, Rd21), (Ra8, Rb1, Rc4, Rd22), (Ra8, Rb1, Rc4, Rd23), (Ra 8, Rb1, Rc4, Rd24), (Ra8, Rb1, Rc4, Rd25), (Ra8, Rb1, Rc4, Rd26), (Ra8, Rb1, Rc4, Rd27), (Ra8, Rb1, Rc4, Rd28), ( (Ra8, Rb1, Rc4, Rd29), (Ra8, Rb1, Rc5, Rd1), (Ra8, Rb1, Rc5, Rd2), (Ra8, Rb1, Rc5, Rd3), (Ra8, Rb1, Rc5,8Rd4), (Ra8, Rb1, Rc5, Rd5), (Ra8, Rb1, Rc5, Rd6), (Ra8, Rb1, Rc5, Rd7), (Ra8, Rb1, Rc5, Rd8), (Ra8, Rb1, Rc5, Rd9), (Ra8, Rb1, Rc5, Rd10), (Ra8, Rb1, Rc5, Rd11), (Ra8, Rb1, Rc5, Rd12), (Ra8, Rb1, Rc5, Rd13), (Ra8, Rb1, Rc5, Rd14), (Ra8, Rb1, Rc5, Rd15), (Ra8, Rb1, Rc5, Rd16), (Ra8, Rb1, Rc5, Rd17), (Ra8, Rb1, Rc5, Rd18), (Ra8, Rb1, Rc5, Rd19), (Ra8, Rb1, Rc5, Rd20), (Ra8, Rb1, Rc5, Rd21), (Ra8, Rb1, Rc5, Rd22), (Ra8, Rb1, Rc5, Rd23), (Ra8, Rb1, Rc5, Rd24), (Ra8, Rb1, Rc5, Rd25), (Ra8, Rb1, Rc5, Rd26), (Ra8, Rb1, Rc5, Rd27), (Ra8, Rb1, Rc5, Rd28), (Ra8, Rb1, Rc5, Rd29), Ra8, Rb2, Rc1, Rd1), (Ra8, Rb2, Rc1, Rd2), (Ra8, Rb2, Rc 1, Rd3), (Ra8, Rb2, Rc1, Rd4), (Ra8, Rb2, Rc1, Rd5), (Ra8, Rb2, Rc1, Rd6), (Ra8, Rb2, Rc1, Rd7), (Ra8, Rb2, Rc1, Rd8), (Ra8, Rb2, Rc1, Rd9), (Ra8, Rb2, Rc1, Rd10), (Ra8, Rb2, Rc1, Rd11), (Ra8, Rb2, Rc1, Rd12), (Ra8, Rb2, Rc1, Rd13), (Ra8, Rb2, Rc1, Rd14), (Ra8, Rb2, Rc1, Rd15), (Ra8, Rb2, Rc1, Rd16), (Ra8, Rb2, Rc1, Rd17), (Ra8, Rb2, Rc1, Rd18), (Ra8, Rb2, Rc1, Rd19), (Ra8, Rb2, Rc1, Rd20), (Ra8, Rb2, Rc1, Rd21), (Ra8, Rb2, Rc1, Rd22), (Ra8, Rb2, Rc1, Rd23), (Ra8, Rb2, Rc1, Rd24), (Ra8, Rb2, Rc1, Rd25), (Ra8, Rb2, Rc1, Rd26), (Ra8, Rb2, Rc1, Rd27), (Ra8, Rb2, Rc1, Rd28), (Ra8, Rb2, Rc1, Rd29), (Ra8, Rb2, Rc2, Rd1), (Ra8, Rb2, Rc2, Rd2), (Ra8, Rb2, Rc2, Rd3), (Ra8, Rb2, Rc2, Rd4), (Ra8, Rb2, Rc2, Rd5), (Ra8, Rb2, Rc2, Rd6), (Ra8, Rb2, Rc2, Rd7), (Ra8, Rb2, Rc2, Rd8), (Ra8, Rb2, Rc2, Rd9), (Ra8, Rb2, Rc2, Rd10), (Ra8, Rb2, Rc2, Rd11), (Ra8, Rb2, Rc2, Rd12), (Ra8, Rb2, Rc2, Rd13), (Ra8, Rb2, Rc2, Rd15), (Ra8, Rb2, Rc2, Rd16), (Ra8, Rb2, Rc2, Rd17), (Ra8, Rb2, Rc2, Rd18), (Ra8, Rb2, Rc2, Rd19), (Ra8, Rb2, Rc2, Rd20), (Ra8, Rb2, Rc2, Rd21), (Ra8, Rb2, Rc2, Rd22), (Ra8, Rb2, Rc2, Rd23), (Ra8, Rb2, Rc2, Rd24), (Ra8, Rb2, Rc2, Rd25), (Ra8, Rb2, Rc2, Rd26), (Ra8, Rb2, Rc2, Rd27), (Ra8, Rb2, Rc2, Rd28), (Ra8, Rb2, Rc2, Rd29), (Ra8, Rb2, Rc3, Rd1), (Ra8, Rb2, Rc3, Rd2),

(Ra8, Rb2, Rc3, Rd3), (Ra8, Rb2, Rc3, Rd4), (Ra8, Rb2, Rc3, Rd5), (Ra8, Rb2, Rc3, Rd6), (Ra8, Rb2, Rc3, Rd7), (Ra8, Rb2, Rc3, Rd8), (Ra8, Rb2, Rc3, Rd9), (Ra8, Rb2, Rc3, Rd10), (Ra8, Rb2, Rc3, Rd11), (Ra8, Rb2, Rc3, Rd12), (Ra8, Rb2, Rc3, Rd13), (Ra8, Rb2, Rc3, Rd14), (Ra8, Rb2, Rc3, Rd15), (Ra8, Rb2, Rc3, Rd16), (Ra8, Rb2, Rc3, Rd17), (Ra8, Rb2, Rc3, Rd18), (Ra8, Rb2, Rc3, Rd19), (Ra8, Rb2, Rc3, Rd20), (Ra8, Rb2, Rc3, Rd21), (Ra8, Rb2, Rc3, Rd22), (Ra8, Rb2, Rc3, Rd23), (Ra8, Rb2, Rc3, Rd24), (Ra8, Rb2, Rc3, Rd25), (Ra8, Rb2, Rc3, Rd26), (Ra8, Rb2, Rc3, Rd27), (Ra8, Rb2, Rc3, Rd28), (Ra8, Rb2, Rc3, Rd29), (Ra8, Rb2, Rc4, Rd1), (Ra8, Rb2, Rc4, Rd2), (Ra8, Rb2, Rc4, Rd3), (Ra8, Rb2, Rc4, Rd4), (Ra8, Rb2, Rc4, Rd5), (Ra8, Rb2, Rc4, Rd6), (Ra8, Rb2, Rc4, Rd7), (Ra8, Rb2, Rc4, Rd8), (Ra8, Rb2, Rc4, Rd9), (Ra8, Rb2, Rc4, Rd10), (Ra8, Rb2, Rc4, Rd11), (Ra8, Rb2, Rc4, Rd12), (Ra8, Rb2, Rc4, Rd13), (Ra8, Rb2, Rc4, Rd14), (Ra8, Rb2, Rc4, Rd15), (Ra8, Rb 2, Rc4, Rd16), (Ra8, Rb2, Rc4, Rd17), (Ra8, Rb2, Rc4, Rd18), (Ra8, Rb2, Rc4, Rd19), (Ra8, Rb2, Rc4, Rd20), (Ra8, Rb2, Rc4, Rd21), (Ra8, Rb2, Rc4, Rd22), (Ra8, Rb2, Rc4, Rd23), (Ra8, Rb2, Rc4, Rd24), (Ra8, Rb2, Rc4, Rd25), (Ra8, Rb2, Rc4, Rd26), (Ra8, Rb2, Rc4, Rd27), (Ra8, Rb2, Rc4, Rd28), (Ra8, Rb2, Rc4, Rd29), (Ra8, Rb2, Rc5, Rd1), (Ra8, Rb2, Rc5, Rd2), (Ra8, Rb2, Rc5, Rd3), (Ra8, Rb2, Rc5, Rd4), (Ra8, Rb2, Rc5, Rd5), (Ra8, Rb2, Rc5, Rd6), (Ra8, Rb2, Rc5, Rd7), (Ra8, Rb2, Rc5, Rd8), (Ra8, Rb2, Rc5, Rd9), (Ra8, Rb2, Rc5, Rd10), (Ra8, Rb2, Rc5, Rd11), (Ra8, Rb2, Rc5, Rd12), (Ra8, Rb2, Rc5, Rd13), (Ra8, Rb2, Rc5, Rd14), (Ra8, Rb2, Rc5, Rd15), (Ra8, Rb2, Rc5, Rd16), (Ra8, Rb2, Rc5, Rd17), (Ra8, Rb2, Rc5, Rd18), (Ra8, Rb2, Rc5, Rd19), (Ra8, Rb2, Rc5, Rd20), (Ra8, Rb2, Rc5, Rd21), (Ra8, Rb2, Rc5, Rd22), (Ra8, Rb2, Rc5, Rd23), (Ra8, Rb2, Rc5, Rd24), (Ra8, Rb2, Rc5, Rd25), (Ra8, Rb2, Rc5, Rd26), (Ra8, Rb2, Rc5, Rd27), (Ra8, Rb2, Rc5, Rd28), (Ra8, Rb2 , Rc5, Rd29), (Ra9, Rb1, Rc1, Rd1), (Ra9, Rb1, Rc1, Rd2), (Ra9, Rb1, Rc1, Rd3), (Ra9, Rb1, Rc1, Rd4), (Ra9, Rb1 , Rc1, Rd5), (Ra9, Rb1, Rc1, Rd6), (Ra9, Rb1, Rc1, Rd7), (Ra9, Rb1, Rc1, Rd8), (Ra9, Rb1, Rc1, Rd9), (Ra9, Rb1 , Rc1, Rd10), (Ra9, Rb1, Rc1, Rd11), (Ra9, Rb1, Rc1, Rd12), (Ra9, Rb1, Rc1, Rd13), (Ra9, Rb1, Rc1, Rd14), (Ra9, Rb1 , Rc1, Rd15), (Ra9, Rb1, Rc1, Rd16), (Ra9, Rb1, Rc1, Rd17), (Ra9, Rb1, Rc1, Rd18), (Ra9, Rb1, Rc1, Rd19), (Ra9, Rb1 , Rc1, Rd20), (Ra9, Rb1, Rc1, Rd21), (Ra9, Rb1, Rc1, Rd22), (Ra9, Rb1, Rc1, Rd23), (Ra9, Rb1, Rc1, Rd24), (Ra9, Rb1 , Rc1, Rd25), (Ra9, Rb1, Rc1, Rd26), (Ra9, Rb1, Rc1, Rd27), (Ra9, Rb1, Rc1, Rd28), (Ra9, Rb1, Rc1, Rd29), (Ra9, Rb1 , Rc2, Rd1), (Ra9, Rb1, Rc2, Rd2), (Ra9, Rb1, Rc2, Rd3), (Ra9, Rb1, Rc2, Rd4), (Ra9, Rb1, Rc2, Rd5), (Ra9, Rb1 , Rc2, Rd6), (Ra9, Rb1, Rc2, Rd7), (Ra9, Rb1, Rc2, Rd8), (Ra9, Rb1, Rc2, Rd9), (Ra9, Rb1, Rc2, Rd10), (Ra9, Rb1 , Rc2, Rd11), (Ra9, Rb1, Rc2, Rd12), (Ra9, Rb1, Rc2, Rd1 3), (Ra9, Rb1, Rc2, Rd14), (Ra9, Rb1, Rc2, Rd15), (Ra9, Rb1, Rc2, Rd16), (Ra9, Rb1, Rc2, Rd17), (Ra9, Rb1, Rc2, Rd18), (Ra9, Rb1, Rc2, Rd19), (Ra9, Rb1, Rc2, Rd20), (Ra9, Rb1, Rc2, Rd21), (Ra9, Rb1, Rc2, Rd22), (Ra9, Rb1, Rc2, Rd23), (Ra9, Rb1, Rc2, Rd24), (Ra9, Rb1, Rc2, Rd25), (Ra9, Rb1, Rc2, Rd26), (Ra9, Rb1, Rc2, Rd27), (Ra9, Rb1, Rc2, Rd28), (Ra9, Rb1, Rc2, Rd29), (Ra9, Rb1, Rc3, Rd1), (Ra9, Rb1, Rc3, Rd2), (Ra9, Rb1, Rc3, Rd3), (Ra9, Rb1, Rc3, Rd4), (Ra9, Rb1, Rc3, Rd5), (Ra9, Rb1, Rc3, Rd6), (Ra9, Rb1, Rc3, Rd7), (Ra9, Rb1, Rc3, Rd8), (Ra9, Rb1, Rc3, Rd9), (Ra9, Rb1, Rc3, Rd10), (Ra9, Rb1, Rc3, Rd11), (Ra9, Rb1, Rc3, Rd12), (Ra9, Rb1, Rc3, Rd13), (Ra9, Rb1, Rc3, Rd14), (Ra9, Rb1, Rc3, Rd15), (Ra9, Rb1, Rc3, Rd16), (Ra9, Rb1, Rc3, Rd17), (Ra9, Rb1, Rc3, Rd18), (Ra9, Rb1, Rc3, Rd19), (Ra9, Rb1, Rc3, Rd20), (Ra9, Rb1, Rc3, Rd21), (Ra9, Rb1, Rc3, Rd22), (Ra9, Rb1, Rc3, Rd23), (Ra9, Rb1, Rc3, Rd24), (Ra9, Rb1, Rc3, Rd25), (Ra9, Rb1, Rc3, Rd26 ), (Ra9, Rb1, Rc3, Rd27), (Ra9, Rb1, Rc3, Rd28), (Ra9, Rb1, Rc3, Rd29), (Ra9, Rb1, Rc4, Rd1), (Ra9, Rb1, Rc4, Rd2) ), (Ra9, Rb1, Rc4, Rd3), (Ra9, Rb1, Rc4, Rd4), (Ra9, Rb1, Rc4, Rd5), (Ra9, Rb1, Rc4, Rd6), (Ra9, Rb1, Rc4, Rd7) ), (Ra9, Rb1, Rc4, Rd8), (Ra9, Rb1, Rc4, Rd9), (Ra9, Rb1, Rc4, Rd10), (Ra9, Rb1, Rc4, Rd11), (Ra9, Rb1, Rc4, Rd12) ), (Ra9, Rb1, Rc4, Rd13), (Ra9, Rb1, Rc4, Rd14), (Ra9, Rb1, Rc4, Rd15), (Ra9, Rb1, Rc4, Rd16), (Ra9, Rb1, Rc4, Rd17) ), (Ra9, Rb1, Rc4, Rd18), (Ra9, Rb1, Rc4, Rd19), (Ra9, Rb1, Rc4, Rd20), (Ra9, Rb1, Rc4, Rd21), (Ra9, Rb1, Rc4, Rd22) ), (Ra9, Rb1, Rc4, Rd23), (Ra9, Rb1, Rc4, Rd24), (Ra9, Rb1, Rc4, Rd25), (Ra9, Rb1, Rc4, Rd26), (Ra9, Rb1, Rc4, Rd27) ), (Ra9, Rb1, Rc4, Rd28), (Ra9, Rb1, Rc4, Rd29), (Ra9, Rb1, Rc5, Rd1), (Ra9, Rb1, Rc5, Rd2), (Ra9, Rb1, Rc5, Rd3) ), (Ra9, Rb1, Rc5, Rd4), (Ra9, Rb1, Rc5, Rd5), (Ra9, Rb1, Rc5, Rd6), (Ra9, Rb1, Rc5, Rd7), (Ra9, Rb1, Rc5, Rd8) ), (Ra9, Rb1, Rc5, Rd9), (Ra9, Rb1, Rc5, Rd10), (Ra9, Rb1, Rc5, Rd11), (Ra9, Rb1, Rc5, Rd12), (Ra9, Rb1, Rc5, Rd13), (Ra9, Rb1, Rc5, Rd14), (Ra9, Rb1, Rc5, Rd15), (Ra9, Rb1, Rc5, Rd16), (Ra9, Rb1, Rc5, Rd17), (Ra9, Rb1, Rc5, Rd18), (Ra9, Rb1, Rc5, Rd19), (Ra9, Rb1, Rc5, Rd20), (Ra9, Rb1, Rc5, Rd21), (Ra9, Rb1, Rc5, Rd22), (Ra9, Rb1, Rc5, Rd23), (Ra9, Rb1, Rc5, Rd24), (Ra9, Rb1, Rc5, Rd25), (Ra9, Rb1, Rc5, Rd26), (Ra9, Rb1, Rc5, Rd27), (Ra9, Rb1, Rc5, Rd28), (Ra9, Rb1, Rc5, Rd29), (Ra9, Rb2, Rc1, Rd1), (Ra9, Rb2, Rc1, Rd2), (Ra9, Rb2, Rc1, Rd3), (Ra9, Rb2, Rc1, Rd4), (Ra9, Rb2, Rc1, Rd5), (Ra9, Rb2, Rc1, Rd6), (Ra9, Rb2, Rc1, Rd7), (Ra9, Rb2, Rc1, Rd8), (Ra9, Rb2, Rc1, Rd9), (Ra9, Rb2, Rc1, Rd10), (Ra9, Rb2, Rc1, Rd11), (Ra9, Rb2, Rc1, Rd12), (Ra9, Rb2, Rc1, Rd13), (Ra9, Rb2, Rc1, Rd14), (Ra9, Rb2, Rc1, Rd15), (Ra9, Rb2, Rc1, Rd16), (Ra9, Rb2, Rc1, Rd17), (Ra9, Rb2, Rc1, Rd18), (Ra9, Rb2, Rc1, Rd19), (Ra9, Rb2, Rc1, Rd20), (Ra9, Rb2, Rc1, Rd21), (Ra9, Rb2, Rc1, Rd22), (Ra9, Rb2, Rc1, Rd23), (Ra9, R b2, Rc1, Rd24), (Ra9, Rb2, Rc1, Rd25), (Ra9, Rb2, Rc1, Rd26), (Ra9, Rb2, Rc1, Rd27), (Ra9, Rb2, Rc1, Rd28), (Ra9, Rb2, Rc1, Rd29), (Ra9, Rb2, Rc2, Rd1), (Ra9, Rb2, Rc2, Rd2), (Ra9, Rb2, Rc2, Rd3), (Ra9, Rb2, Rc2, Rd4), (Ra9, Rb2, Rc2, Rd5), (Ra9, Rb2, Rc2, Rd6), (Ra9, Rb2, Rc2, Rd7), (Ra9, Rb2, Rc2, Rd8), (Ra9, Rb2, Rc2, Rd9), (Ra9, Rb2, Rc2, Rd10), (Ra9, Rb2, Rc2, Rd11), (Ra9, Rb2, Rc2, Rd12), (Ra9, Rb2, Rc2, Rd13), (Ra9, Rb2, Rc2, Rd14), (Ra9, Rb2, Rc2, Rd15), (Ra9, Rb2, Rc2, Rd16), (Ra9, Rb2, Rc2, Rd17), (Ra9, Rb2, Rc2, Rd18), (Ra9, Rb2, Rc2, Rd19), (Ra9, Rb2, Rc2, Rd20), (Ra9, Rb2, Rc2, Rd21), (Ra9, Rb2, Rc2, Rd22), (Ra9, Rb2, Rc2, Rd23), (Ra9, Rb2, Rc2, Rd24), (Ra9, Rb2, Rc2, Rd25), (Ra9, Rb2, Rc2, Rd26), (Ra9, Rb2, Rc2, Rd27), (Ra9, Rb2, Rc2, Rd28), (Ra9, Rb2, Rc2, Rd29), (Ra9, Rb2, Rc3, Rd1), (Ra9, Rb2, Rc3, Rd2), (Ra9, Rb2, Rc3, Rd3), (Ra9, Rb2, Rc3, Rd4), (Ra9, Rb2, Rc3, Rd5), (Ra9, Rb2, Rc3, Rd6), (Ra9, Rb2, Rc3, Rd7), (Ra9, Rb2, Rc3, Rd8), (Ra9, Rb2, Rc3, Rd9), (Ra9, Rb2, Rc3, Rd10), (Ra9, Rb2, Rc3, Rd11), (Ra9, Rb2, Rc3, Rd12), (Ra9, Rb2, Rc3, Rd13), (Ra9, Rb2, Rc3, Rd14), (Ra9, Rb2, Rc3, Rd15), (Ra9, Rb2, Rc3, Rd16), (Ra9, Rb2, Rc3, Rd17), (Ra9, Rb2, Rc3, Rd18), (Ra9, Rb2, Rc3, Rd19), (Ra9, Rb2, Rc3, Rd20), (Ra9, Rb2, Rc3, Rd21), (Ra9, Rb2, Rc3, Rd22), (Ra9, Rb2, Rc3, Rd23), (Ra9, Rb2, Rc3, Rd24), (Ra9, Rb2, Rc3, Rd25), (Ra9, Rb2, Rc3, Rd26), (Ra9, Rb2, Rc3, Rd27), (Ra9, Rb2, Rc3, Rd28), (Ra9, Rb2, Rc3, Rd29), (Ra9, Rb2, Rc4, Rd1), (Ra9, Rb2, Rc4, Rd2), (Ra9, Rb2, Rc4, Rd3), (Ra9, Rb2, Rc4, Rd4), (Ra9, Rb2, Rc4, Rd5), (Ra9, Rb2, Rc4, Rd6), (Ra9, Rb2, Rc4, Rd7), (Ra9, Rb2, Rc4, Rd8), (Ra9, Rb2, Rc4, Rd9), (Ra9, Rb2, Rc4, Rd10), (Ra9, Rb2, Rc4, Rd11), (Ra9, Rb2, Rc4, Rd12), (Ra9, Rb2, Rc4, Rd13), (Ra9, Rb2, Rc4, Rd14), (Ra9, Rb2, Rc4, Rd15), (Ra9, Rb2, Rc4, Rd16), (Ra9, Rb2, Rc4, Rd17), (Ra9, Rb2, Rc4, Rd18), (Ra9, Rb2, Rc4, Rd19), (Ra9, Rb2, Rc4, Rd20), (Ra9, Rb2, Rc4, Rd 21), (Ra9, Rb2, Rc4, Rd22), (Ra9, Rb2, Rc4, Rd23), (Ra9, Rb2, Rc4, Rd24), (Ra9, Rb2, Rc4, Rd25), (Ra9, Rb2, Rc4, Rd26), (Ra9, Rb2, Rc4, Rd27), (Ra9, Rb2, Rc4, Rd28), (Ra9, Rb2, Rc4, Rd29), (Ra9, Rb2, Rc5, Rd1), (Ra9, Rb2, Rc5, Rd2), (Ra9, Rb2, Rc5, Rd3), (Ra9, Rb2, Rc5, Rd4), (Ra9, Rb2, Rc5, Rd5), (Ra9, Rb2, Rc5, Rd6), (Ra9, Rb2, Rc5, Rd7), (Ra9, Rb2, Rc5, Rd8), (Ra9, Rb2, Rc5, Rd9), (Ra9, Rb2, Rc5, Rd10), (Ra9, Rb2, Rc5, Rd11), (Ra9, Rb2, Rc5, Rd12), (Ra9, Rb2, Rc5, Rd13), (Ra9, Rb2, Rc5, Rd14), (Ra9, Rb2, Rc5, Rd15), (Ra9, Rb2, Rc5, Rd16), (Ra9, Rb2, Rc5, Rd17), (Ra9, Rb2, Rc5, Rd18), (Ra9, Rb2, Rc5, Rd19), (Ra9, Rb2, Rc5, Rd20), (Ra9, Rb2, Rc5, Rd21), (Ra9, Rb2, Rc5, Rd22), (Ra9, Rb2, Rc5, Rd23), (Ra9, Rb2, Rc5, Rd24), (Ra9, Rb2, Rc5, Rd25), (Ra9, Rb2, Rc5, Rd26), (Ra9, Rb2, Rc5, Rd27), (Ra9, Rb2, Rc5, Rd28), (Ra9, Rb2, Rc5, Rd29), (Ra10, Rb1, Rc1, Rd1), (Ra10, Rb1, Rc1, Rd2), (Ra10, Rb1, Rc1, Rd3), (Ra10, Rb1, Rc1, Rd4), (Ra10, Rb1, Rc1, Rd 5), (Ra10, Rb1, Rc1, Rd6), (Ra10, Rb1, Rc1, Rd7), (Ra10, Rb1, Rc1, Rd8), (Ra10, Rb1, Rc1, Rd9), (Ra10, Rb1, Rc1, Rd10), (Ra10, Rb1, Rc1, Rd11), (Ra10, Rb1, Rc1, Rd12), (Ra10, Rb1, Rc1, Rd13), (Ra10, Rb1, Rc1, Rd14), (Ra10, Rb1, Rc1, Rd15), (Ra10, Rb1, Rc1, Rd16), (Ra10, Rb1, Rc1, Rd17), (Ra10, Rb1, Rc1, Rd18), (Ra10, Rb1, Rc1, Rd19), (Ra10, Rb1, Rc1, Rd20), (Ra10, Rb1, Rc1, Rd21), (Ra10, Rb1, Rc1, Rd22), (Ra10, Rb1, Rc1, Rd23), (Ra10, Rb1, Rc1, Rd24), (Ra10, Rb1, Rc1, Rd25), (Ra10, Rb1, Rc1, Rd26), (Ra10, Rb1, Rc1, Rd27), (Ra10, Rb1, Rc1, Rd28), (Ra10, Rb1, Rc1, Rd29), (Ra10, Rb1, Rc2, Rd1), (Ra10, Rb1, Rc2, Rd2), (Ra10, Rb1, Rc2, Rd3), (Ra10, Rb1, Rc2, Rd4), (Ra10, Rb1, Rc2, Rd5), (Ra10, Rb1, Rc2, Rd6), (Ra10, Rb1, Rc2, Rd7), (Ra10, Rb1, Rc2, Rd8), (Ra10, Rb1, Rc2, Rd9), (Ra10, Rb1, Rc2, Rd10), (Ra10, Rb1, Rc2, Rd11), (Ra10, Rb1, Rc2, Rd12), (Ra10, Rb1, Rc2, Rd13), (Ra10, Rb1, Rc2, Rd14), (Ra10, Rb1, Rc2, Rd15), (Ra10, Rb1, Rc2, Rd16), (Ra10, R b1, Rc2, Rd17), (Ra10, Rb1, Rc2, Rd18), (Ra10, Rb1, Rc2, Rd19), (Ra10, Rb1, Rc2, Rd20), (Ra10, Rb1, Rc2, Rd21), (Ra10, Rb1, Rc2, Rd22), (Ra10, Rb1, Rc2, Rd23), (Ra10, Rb1, Rc2, Rd24), (Ra10, Rb1, Rc2, Rd25), (Ra10, Rb1, Rc2, Rd26), (Ra10, Rb1, Rc2, Rd27), (Ra10, Rb1, Rc2, Rd28), (Ra10, Rb1, Rc2, Rd29), (Ra10, Rb1, Rc3, Rd1), (Ra10, Rb1, Rc3, Rd2), (Ra10, Rb1, Rc3, Rd3), (Ra10, Rb1, Rc3, Rd4), (Ra10, Rb1, Rc3, Rd5), (Ra10, Rb1, Rc3, Rd6), (Ra10, Rb1, Rc3, Rd7), (Ra10, Rb1, Rc3, Rd8), (Ra10, Rb1, Rc3, Rd9), (Ra10, Rb1, Rc3, Rd10), (Ra10, Rb1, Rc3, Rd11), (Ra10, Rb1, Rc3, Rd12), (Ra10, Rb1, Rc3, Rd13), (Ra10, Rb1, Rc3, Rd14), (Ra10, Rb1, Rc3, Rd15), (Ra10
, Rb1, Rc3, Rd16), (Ra10, Rb1, Rc3, Rd17), (Ra10, Rb1, Rc3, Rd18), (Ra10, Rb1, Rc3, Rd19), (Ra10, Rb1, Rc3, Rd20), (Ra10 , Rb1, Rc3, Rd21), (Ra10, Rb1, Rc3, Rd22), (Ra10, Rb1, Rc3, Rd23), (Ra10, Rb1, Rc3, Rd24), (Ra10, Rb1, Rc3, Rd25), (Ra10 , Rb1, Rc3, Rd26), (Ra10, Rb1, Rc3, Rd27), (Ra10, Rb1, Rc3, Rd28), (Ra10, Rb1, Rc3, Rd29), (Ra10, Rb1, Rc4, Rd1), (Ra10 , Rb1, Rc4, Rd2), (Ra10, Rb1, Rc4, Rd3), (Ra10, Rb1, Rc4, Rd4), (Ra10, Rb1, Rc4, Rd5), (Ra10, Rb1, Rc4, Rd6), (Ra10 , Rb1, Rc4, Rd7), (Ra10, Rb1, Rc4, Rd8), (Ra10, Rb1, Rc4, Rd9), (Ra10, Rb1, Rc4, Rd10), (Ra10, Rb1, Rc4, Rd11), (Ra10 , Rb1, Rc4, Rd12), (Ra10, Rb1, Rc4, Rd13), (Ra10, Rb1, Rc4, Rd14), (Ra10, Rb1, Rc4, Rd15), (Ra10, Rb1, Rc4, Rd16), (Ra10 , Rb1, Rc4, Rd17), (Ra10, Rb1, Rc4, Rd18), (Ra10, Rb1, Rc4, Rd19), (Ra10, Rb1, Rc4, Rd20), (Ra10, Rb1, Rc4, Rd21), (Ra10 , Rb1, Rc4, Rd22), (Ra10, Rb1, Rc4, Rd23), (Ra10, Rb1, Rc4, Rd24), (Ra10, Rb1, Rc4, Rd25), (Ra10, Rb1, Rc4, Rd26), (Ra10 , Rb1, Rc 4, Rd27), (Ra10, Rb1, Rc4, Rd28), (Ra10, Rb1, Rc4, Rd29), (Ra10, Rb1, Rc5, Rd1), (Ra10, Rb1, Rc5, Rd2), (Ra10, Rb1, Rc5, Rd3), (Ra10, Rb1, Rc5, Rd4), (Ra10, Rb1, Rc5, Rd5), (Ra10, Rb1, Rc5, Rd6), (Ra10, Rb1, Rc5, Rd7), (Ra10, Rb1, Rc5, Rd8), (Ra10, Rb1, Rc5, Rd9), (Ra10, Rb1, Rc5, Rd10), (Ra10, Rb1, Rc5, Rd11), (Ra10, Rb1, Rc5, Rd12), (Ra10, Rb1, Rc5, Rd13), (Ra10, Rb1, Rc5, Rd14), (Ra10, Rb1, Rc5, Rd15), (Ra10, Rb1, Rc5, Rd16), (Ra10, Rb1, Rc5, Rd17), (Ra10, Rb1, Rc5, Rd18), (Ra10, Rb1, Rc5, Rd19), (Ra10, Rb1, Rc5, Rd20), (Ra10, Rb1, Rc5, Rd21), (Ra10, Rb1, Rc5, Rd22), (Ra10, Rb1, Rc5, Rd23), (Ra10, Rb1, Rc5, Rd24), (Ra10, Rb1, Rc5, Rd25), (Ra10, Rb1, Rc5, Rd26), (Ra10, Rb1, Rc5, Rd27), (Ra10, Rb1, Rc5, Rd28), (Ra10, Rb1, Rc5, Rd29), (Ra10, Rb2, Rc1, Rd1),

(Ra10, Rb2, Rc1, Rd2), (Ra10, Rb2, Rc1, (Rd3), (Ra10, Rb2, Rc1, Rd4), (Ra10, Rb2, Rc1, Rd5), (Ra10, Rb2, Rc1, Rd6), (Ra10, Rb2, Rc1, Rd7), (Ra10, Rb2, Rc1, Rd8), (Ra10, Rb2, Rc1, Rd9), (Ra10, Rb2, Rc1, Rd10), (Ra10, Rb2, Rc1, Rd11), (Ra10, Rb2, Rc1, Rd12), (Ra10, Rb2, Rc1, Rd14), (Ra10, Rb2, Rc1, Rd15), (Ra10, Rb2, Rc1, Rd16), (Ra10, Rb2, Rc1, Rd17), (Ra10, Rb2, Rc1, Rd19), (Ra10, Rb2, Rc1, Rd20), (Ra10, Rb2, Rc1, Rd21), (Ra10, Rb2, Rc1, Rd22), (Ra10, Rb2, Rc1, Rd24), (Ra10, Rb2, Rc1, Rd25), (Ra10, Rb2, Rc1, Rd26), (Ra10, Rb2, Rc1, Rd27), (Ra10, Rb2, Rc1, Rd29), (Ra10, Rb2, Rc2, Rd1), (Ra10, Rb2, Rc2, Rd2), (Ra10, Rb2, Rc2, Rd3), (Ra10, Rb2, Rc2, Rd5), (Ra10, Rb2, Rc2, Rd6), (Ra10, Rb2, Rc2, Rd7), (Ra10, Rb2, Rc2, Rd8), (Ra10, Rb2, Rc2, Rd9), (Ra10, Rb2, Rc2, Rd10), (Ra10, Rb2, Rc2, Rd11), (Ra10, Rb2, Rc2, Rd12), (Ra10, Rb2, Rc2, Rd13), (Ra10, Rb2, Rc2, Rd14), (Ra10, Rb2, Rc2, Rd15), (Ra10, Rb2, Rc2, Rd16), (Ra10, Rb2, Rc2, Rd17), (Ra10, Rb2, Rc2, Rd18), (Ra10, Rb2, Rc2, Rd19), (Ra10, Rb2, Rc2, Rd20), (Ra10, Rb2, Rc2, Rd21), (Ra10, Rb2, Rc2, Rd22), (Ra10, Rb2, Rc2, Rd23), (Ra10, Rb2, Rc2, Rd24), (Ra10, Rb2, Rc2, Rd25), (Ra10, Rb2, Rc2, Rd26), (Ra10, Rb2, Rc2, Rd27), (Ra10, Rb2, Rc2, Rd28), (Ra10, Rb2, Rc2, Rd29), (Ra10, Rb2, Rc3, Rd1), (Ra10, Rb2, Rc3, Rd2), (Ra10, Rb2, Rc3, Rd3), (Ra10, Rb2, Rc3, Rd4), (Ra10, Rb2, Rc3, Rd5), (Ra10, Rb2, Rc3, Rd6), (Ra10, Rb2, Rc3, Rd7), (Ra10, Rb2, Rc3, Rd8), (Ra10, Rb2, Rc3, Rd9), (Ra10, Rb2, Rc3, Rd10), (Ra10, Rb2, Rc3, Rd11), (Ra10, Rb2, Rc3, Rd12), (Ra10, Rb2, Rc3, Rd13), (Ra10, Rb2, Rc3, Rd14), (Ra10, Rb2, Rc3, Rd15), (Ra10, Rb2, Rc3, Rd16), (Ra10, Rb2, Rc3, Rd17), (Ra10, Rb2, Rc3, Rd18), (Ra10, Rb2, Rc3, Rd19), (Ra10, Rb2, Rc3, Rd20), (Ra10, Rb2, Rc3, Rd21), (Ra10, Rb2, Rc3, Rd22), (Ra10, Rb2, Rc3, Rd23), (Ra10, Rb2, Rc3, Rd24), (Ra10, Rb2, Rc3, Rd25), (Ra10, Rb2, Rc3, Rd26), (Ra10, Rb2, Rc3, Rd27), (Ra10, Rb2, Rc3, Rd28), (Ra10, Rb2, Rc3, Rd29), (Ra10, Rb2, Rc4, Rd1), (Ra10, Rb2, Rc4, Rd2), (Ra10, Rb2, Rc4, Rd3), (Ra10, Rb2, Rc4, Rd4), (Ra10, Rb2, Rc4, Rd5), (Ra10, Rb2, Rc4, Rd6), (Ra10, Rb2, Rc4, Rd7), (Ra10, Rb2, Rc4, Rd8), (Ra10, Rb2, Rc4, Rd9), (Ra10, Rb2, Rc4, Rd10), (Ra10, Rb2, Rc4, Rd11), (Ra10, Rb2, Rc4, Rd12), (Ra10, Rb2, Rc4, Rd13), (Ra10, Rb2, Rc4, Rd14), (Ra10, Rb2, Rc4, Rd15), (Ra10, Rb2, Rc4, Rd16), (Ra10, Rb2, Rc4, Rd17), (Ra10, Rb2, Rc4, Rd18), (Ra10, Rb2, Rc4, Rd19), (Ra10, Rb2, Rc4, Rd20), (Ra10, Rb2, Rc4, Rd21), (Ra10, Rb2, Rc4, Rd22), (Ra10, R b2, Rc4, Rd23), (Ra10, Rb2, Rc4, Rd24), (Ra10, Rb2, Rc4, Rd25), (Ra10, Rb2, Rc4, Rd26), (Ra10, Rb2, Rc4, Rd27), (Ra10, Rb2, Rc4, Rd28), (Ra10, Rb2, Rc4, Rd29), (Ra10, Rb2, Rc5, Rd1), (Ra10, Rb2, Rc5, Rd2), (Ra10, Rb2, Rc5, Rd3), (Ra10, Rb2, Rc5, Rd4), (Ra10, Rb2, Rc5, Rd5), (Ra10, Rb2, Rc5, Rd6), (Ra10, Rb2, Rc5, Rd7), (Ra10, Rb2, Rc5, Rd8), (Ra10, Rb2, Rc5, Rd9), (Ra10, Rb2, Rc5, Rd10), (Ra10, Rb2, Rc5, Rd11), (Ra10, Rb2, Rc5, Rd12), (Ra10, Rb2, Rc5, Rd13), (Ra10, Rb2, Rc5, Rd14), (Ra10, Rb2, Rc5, Rd15), (Ra10, Rb2, Rc5, Rd16), (Ra10, Rb2, Rc5, Rd17), (Ra10, Rb2, Rc5, Rd18), (Ra10, Rb2, Rc5, Rd19), (Ra10, Rb2, Rc5, Rd20), (Ra10, Rb2, Rc5, Rd21), (Ra10, Rb2, Rc5, Rd22), (Ra10, Rb2, Rc5, Rd23), (Ra10, Rb2, Rc5, Rd24), (Ra10, Rb2, Rc5, Rd25), (Ra10, Rb2, Rc5, Rd26), (Ra10, Rb2, Rc5, Rd27), (Ra10, Rb2, Rc5, Rd28), (Ra10, Rb2, Rc5, Rd29), (Ra11, Rb 1, Rc1, Rd1), (Ra11, Rb1, Rc1, Rd2), (Ra11, Rb1, Rc1, Rd3), (Ra11, Rb1, Rc1, Rd4), (Ra11, Rb1, Rc1, Rd5), (Ra11, Rb1, Rc1, Rd6), (Ra11, Rb1, Rc1, Rd7), (Ra11, Rb1, Rc1, Rd8), (Ra11, Rb1, Rc1, Rd9), (Ra11, Rb1, Rc1, Rd10), (Ra11, Rb1, Rc1, Rd11), (Ra11, Rb1, Rc1, Rd12), (Ra11, Rb1, Rc1, Rd14), (Ra11, Rb1, Rc1, Rd14), (Ra11, Rb1, Rc1, Rd15), (Ra11, Rb1, Rc1, Rd16), (Ra11, Rb1, Rc1, Rd17), (Ra11, Rb1, Rc1, Rd18), (Ra11, Rb1, Rc1, Rd19), (Ra11, Rb1, Rc1, Rd20), (Ra11, Rb1, Rc1, Rd21), (Ra11, Rb1, Rc1, Rd22), (Ra11, Rb1, Rc1, Rd23), (Ra11, Rb1, Rc1, Rd24), (Ra11, Rb1, Rc1, Rd25), (Ra11, Rb1, Rc1, Rd26), (Ra11, Rb1, Rc1, Rd27), (Ra11, Rb1, Rc1, Rd28), (Ra11, Rb1, Rc1, Rd29), (Ra11, Rb1, Rc2, Rd1), (Ra11, Rb1, Rc2, Rd2), (Ra11, Rb1, Rc2, Rd3), (Ra11, Rb1, Rc2, Rd4), (Ra11, Rb1, Rc2, Rd5), (Ra11, Rb1, Rc2, Rd6), (Ra11, Rb1, Rc2, Rd7), (Ra11, Rb1, Rc2, Rd8), (Ra11, Rb1, Rc2, Rd9), (Ra11, Rb1, Rc2, Rd10), (Ra11, Rb1, Rc2, Rd11), (Ra11, Rb1, Rc2, Rd12), (Ra11, Rb1, Rc2, Rd13), (Ra11, Rb1, Rc2, Rd14), (Ra11, Rb1, Rc2, Rd15), (Ra11, Rb1, Rc2, Rd16), (Ra11, Rb1, Rc2, Rd17), (Ra11, Rb1, Rc2, Rd18), (Ra11, Rb1, Rc2, Rd19), (Ra11, Rb1, Rc2, Rd20), (Ra11, Rb1, Rc2, Rd21), (Ra11, Rb1, Rc2, Rd22), (Ra11, Rb1, Rc2, Rd23), (Ra11, Rb1, Rc2, Rd24), (Ra11, Rb1, Rc2, Rd25), (Ra11, Rb1, Rc2, Rd26), (Ra11, Rb1, Rc2, Rd27), (Ra11, Rb1, Rc2, Rd28), (Ra11, Rb1, Rc2, Rd29), (Ra11, Rb1, Rc3, Rd1), (Ra11, Rb1, Rc3, Rd2), (Ra11, Rb1, Rc3, Rd3), (Ra11, Rb1, Rc3, Rd4), (Ra11, Rb1, Rc3, Rd5), (Ra11, Rb1, Rc3, Rd6), (Ra11, Rb1, Rc3, Rd7), (Ra11, Rb1, Rc3, Rd8), (Ra11, Rb1, Rc3, Rd9), (Ra11, Rb1, Rc3, Rd10), (Ra11, Rb1, Rc3, Rd11), (Ra11, Rb1, Rc3, Rd12), (Ra11, Rb1, Rc3, Rd13), (Ra11, Rb1, Rc3, Rd14), (Ra11, Rb1, Rc3, R d15), (Ra11, Rb1, Rc3, Rd16), (Ra11, Rb1, Rc3, Rd17), (Ra11, Rb1, Rc3, Rd18), (Ra11, Rb1, Rc3, Rd19), (Ra11, Rb1, Rc3, Rd20), (Ra11, Rb1, Rc3, Rd21), (Ra11, Rb1, Rc3, Rd22), (Ra11, Rb1, Rc3, Rd23), (Ra11, Rb1, Rc3, Rd24), (Ra11, Rb1, Rc3, Rd25), (Ra11, Rb1, Rc3, Rd26), (Ra11, Rb1, Rc3, Rd27), (Ra11, Rb1, Rc3, Rd28), (Ra11, Rb1, Rc3, Rd29), (Ra11, Rb1, Rc4, Rd1), (Ra11, Rb1, Rc4, Rd2), (Ra11, Rb1, Rc4, Rd3), (Ra11, Rb1, Rc4, Rd4), (Ra11, Rb1, Rc4, Rd5), (Ra11, Rb1, Rc4, Rd6), (Ra11, Rb1, Rc4, Rd7), (Ra11, Rb1, Rc4, Rd8), (Ra11, Rb1, Rc4, Rd9), (Ra11, Rb1, Rc4, Rd10), (Ra11, Rb1, Rc4, Rd11), (Ra11, Rb1, Rc4, Rd12), (Ra11, Rb1, Rc4, Rd13), (Ra11, Rb1, Rc4, Rd14), (Ra11, Rb1, Rc4, Rd15), (Ra11, Rb1, Rc4, Rd16), (Ra11, Rb1, Rc4, Rd17), (Ra11, Rb1, Rc4, Rd18), (Ra11, Rb1, Rc4, Rd19), (Ra11, Rb1, Rc4, Rd20), (Ra11, Rb1, Rc4, Rd21), (Ra11, Rb1, Rc4, Rd 22), (Ra11, Rb1, Rc4, Rd23), (Ra11, Rb1, Rc4, Rd24), (Ra11, Rb1, Rc4, Rd25), (Ra11, Rb1, Rc4, Rd26), (Ra11, Rb1, Rc4, Rd27), (Ra11, Rb1, Rc4, Rd28), (Ra11, Rb1, Rc4, Rd29), (Ra11, Rb1, Rc5, Rd1), (Ra11, Rb1, Rc5, Rd2), (Ra11, Rb1, Rc5, Rd3), (Ra11, Rb1, Rc5, Rd4), (Ra11, Rb1, Rc5, Rd5), (Ra11, Rb1, Rc5, Rd6), (Ra11, Rb1, Rc5, Rd7), (Ra11, Rb1, Rc5, Rd8), (Ra11, Rb1, Rc5, Rd9), (Ra11, Rb1, Rc5, Rd10), (Ra11, Rb1, Rc5, Rd11), (Ra11, Rb1, Rc5, Rd12), (Ra11, Rb1, Rc5, Rd13), (Ra11, Rb1, Rc5, Rd14), (Ra11, Rb1, Rc5, Rd15), (Ra11, Rb1, Rc5, Rd16), (Ra11, Rb1, Rc5, Rd17), (Ra11, Rb1, Rc5, Rd18), (Ra11, Rb1, Rc5, Rd19), (Ra11, Rb1, Rc5, Rd20), (Ra11, Rb1, Rc5, Rd21), (Ra11, Rb1, Rc5, Rd22), (Ra11, Rb1, Rc5, Rd23), (Ra11, Rb1, Rc5, Rd24), (Ra11, Rb1, Rc5, Rd25), (Ra11, Rb1, Rc5, Rd26), (Ra11, Rb1, Rc5, Rd27), (Ra11, Rb1, Rc5, Rd28), (Ra11, Rb1, Rc5, Rd2 9), (Ra11, Rb2, Rc1, Rd1), (Ra11, Rb2, Rc1, Rd2), (Ra11, Rb2, Rc1, Rd3), (Ra11, Rb2, Rc1, Rd4), (Ra11, Rb2, Rc1, Rd5), (Ra11, Rb2, Rc1, Rd6), (Ra11, Rb2, Rc1, Rd7), (Ra11, Rb2, Rc1, Rd8), (Ra11, Rb2, Rc1, Rd9), (Ra11, Rb2, Rc1, Rd10), (Ra11, Rb2, Rc1, Rd11), (Ra11, Rb2, Rc1, Rd12), (Ra11, Rb2, Rc1, Rd13), (Ra11, Rb2, Rc1, Rd14), (Ra11, Rb2, Rc1, Rd15), (Ra11, Rb2, Rc1, Rd16), (Ra11, Rb2, Rc1, Rd17), (Ra11, Rb2, Rc1, Rd18), (Ra11, Rb2, Rc1, Rd19), (Ra11, Rb2, Rc1, Rd20), (Ra11, Rb2, Rc1, Rd21), (Ra11, Rb2, Rc1, Rd22), (Ra11, Rb2, Rc1, Rd23), (Ra11, Rb2, Rc1, Rd24), (Ra11, Rb2, Rc1, Rd25), (Ra11, Rb2, Rc1, Rd26), (Ra11, Rb2, Rc1, Rd27), (Ra11, Rb2, Rc1, Rd28), (Ra11, Rb2, Rc1, Rd29), (Ra11, Rb2, Rc2, Rd1), (Ra11, Rb2, Rc2, Rd2), (Ra11, Rb2, Rc2, Rd3), (Ra11, Rb2, Rc2, Rd4), (Ra11, Rb2, Rc2, Rd5), (Ra11, Rb2, Rc2, Rd6), (Ra11, Rb2, Rc2, Rd7), (Ra 11, Rb2, Rc2, Rd8), (Ra11, Rb2, Rc2, Rd9), (Ra11, Rb2, Rc2, Rd10), (Ra11, Rb2, Rc2, Rd11), (Ra11, Rb2, Rc2, Rd12), ( Ra11, Rb2, Rc2, Rd13), (Ra11, Rb2, Rc2, Rd15), (Ra11, Rb2, Rc2, Rd16), (Ra11, Rb2, Rc2, Rd17), ( (Ra11, Rb2, Rc2, Rd18), (Ra11, Rb2, Rc2, Rd20), (Ra11, Rb2, Rc2, Rd21), (Ra11, Rb2, Rc2, Rd22), ( Ra11, Rb2, Rc2, dRd23), (Ra11, Rb2, Rc2, Rd25), (Ra11, Rb2, Rc2, Rd26), (Ra11, Rb2, Rc2, Rd27), ( (Ra11, Rb2, Rc2, Rd28), (Ra11, Rb2, Rc2, Rd29), (Ra11, Rb2, Rc3, Rd1), (Ra11, Rb2, Rc3, Rd2), (Ra11, Rb2, Rc3, Rd3), (Ra11, Rb2, Rc3, Rd4), (Ra11, Rb2, Rc3, Rd5), (Ra11, Rb2, Rc3, Rd6), (Ra11, Rb2, Rc3, Rd7), (Ra11, Rb2, Rc3, Rd8), Ra11, Rb2, Rc3, Rd9), (Ra11, Rb2, Rc3, Rd10), (Ra11, Rb2, Rc3, Rd11), (Ra11, Rb2, Rc3, Rd12), (Ra11, Rb2, Rc3, Rd13), Ra11, Rb2, Rc3, Rd14), (Ra11, Rb2, Rc3, Rd15), (Ra11, Rb2, Rc3, Rd16), (Ra11, Rb2, Rc3, Rd17), (Ra11, Rb2, Rc3, Rd18), (Ra11, Rb2, Rc3, Rd19), (Ra11, Rb2, Rc3, Rd20), (Ra11, Rb2, Rc3, Rd21), (Ra11, Rb2, Rc3, Rd22), (Ra11, Rb2, Rc3, Rd23), (Ra11, Rb2, Rc3, Rd24), (Ra11, Rb2, Rc3, Rd25), (Ra11, Rb2, Rc3, Rd26), (Ra11, Rb2, Rc3, Rd27), (Ra11, Rb2, Rc3, Rd28), (Ra11, Rb2, Rc3, Rd29), (Ra11, Rb2, Rc4, Rd1), (Ra11, Rb2, Rc4, Rd2), (Ra11, Rb2, Rc4, Rd3), (Ra11, Rb2, Rc4, Rd4), (Ra11, Rb2, Rc4, Rd5), (Ra11, Rb2, Rc4, Rd6), (Ra11, Rb2, Rc4, Rd7), (Ra11, Rb2, Rc4, Rd8), (Ra11, Rb2, Rc4, Rd9), (Ra11, Rb2, Rc4, Rd10), (Ra11, Rb2, Rc4, Rd11), (Ra11, Rb2, Rc4, Rd12), (Ra11, Rb2, Rc4, Rd13), (Ra11, Rb2, Rc4, Rd14),

(Ra11, Rb2, Rc4, Rd15), (Ra11, Rb2, Rc4, Rd16), (Ra11, Rb2, Rc4, Rd17), (Ra11, Rb2, Rc4, Rd18), (Ra11, Rb2, Rc4, Rd19), (Ra11, Rb2, Rc4, Rd20), (Ra11, Rb2, Rc4, Rd21), (Ra11, Rb2, Rc4, Rd22), (Ra11, Rb2, Rc4, Rd23), (Ra11, Rb2, Rc4, Rd24), (Ra11, Rb2, Rc4, Rd25), (Ra11, Rb2, Rc4, Rd27), (Ra11, Rb2, Rc4, Rd28), (Ra11, Rb2, Rc4, Rd29), (Ra11, Rb2, Rc5, Rd1), (Ra11, Rb2, Rc5, Rd2), (Ra11, Rb2, Rc5, Rd3), (Ra11, Rb2, Rc5, Rd4), (Ra11, Rb2, Rc5, Rd5), (Ra11, Rb2, Rc5, Rd6), (Ra11, Rb2, Rc5, Rd7), (Ra11, Rb2,11Rc5, bRd8), (Ra11, Rb2, Rc5, Rd9), (Ra11, Rb2, Rc5, Rd10), (Ra11, Rb2, Rc5, Rd11), (Ra11, Rb2, Rc5, Rd12), (Ra11, Rb2, Rc5, Rd13), (Ra11, Rb2, Rc5, Rd14), (Ra11, Rb2, Rc5, Rd15), (Ra11, Rb2, Rc5, Rd16), (Ra11, Rb2, Rc5, Rd17), (Ra11, Rb2, Rc5, Rd18), (Ra11, Rb2, Rc5, Rd19), (Ra11, Rb2, Rc5, Rd20), (Ra11, Rb2, Rc5, Rd21) (Ra11, Rb2, Rc5, Rd22), (Ra11, Rb2, Rc5, Rd24), (Ra11, Rb2, Rc5, Rd25), (Ra11, Rb2, Rc5, Rd26), (Ra11, Rb2, Rc5, Rd27), (Ra11, Rb2, Rc5, Rd28), (Ra11, Rb2, Rc5, Rd29), (Ra12, Rb1, 、 Rc1, Rd1), (Ra12, Rb1, Rc1, Rd2), (Ra12, Rb1, Rc1, Rd3), (Ra12, Rb1, Rc1, Rd4), (Ra12, Rb1, Rc1, Rd5), (Ra12, Rb1, Rc1, Rd6), (Ra12, Rb1, Rc1, (Rd7), (Ra12, Rb1, Rc1, Rd8), (Ra12, Rb1, Rc1, Rd10), (Ra12, Rb1, Rc1, Rd11), (Ra12, Rb1, Rc1, Rd12), (Ra12, Rb1, Rc1, Rd13), (Ra12, Rb1, Rc1, Rd15), (Ra12, Rb1, Rc1, Rd16), (Ra12, Rb1, Rc1, Rd17), (Ra12, Rb1, Rc1, Rd18), (Ra12, Rb1, Rc1, Rd20), (Ra12, Rb1, Rc1, Rd21), (Ra12, Rb1, Rc1, Rd22), (Ra12, Rb1, Rc1, Rd23), (Ra12, Rb1, Rc1, Rd25), (Ra12, Rb1, Rc1, Rd26), (Ra12, Rb1, Rc1, Rd27), (Ra12, Rb1, Rc1, Rd28), (Ra12, Rb1, Rc1, 29Rd29), (Ra12, Rb1, Rc2, Rd1), (Ra12, Rb1, Rc2, Rd2), (Ra12, Rb1, Rc2, Rd3), (Ra12, Rb1, Rc2, Rd4), (Ra12, Rb1, Rc2, Rd5), (Ra12, Rb1, Rc2, Rd6), (Ra12, Rb1, Rc2, Rd7), (Ra12, Rb1, Rc2, Rd8), (Ra12, Rb1, Rc2, Rd9), (Ra12, Rb1, Rc2, Rd10), (Ra12, Rb1, Rc2, Rd12), (Ra12, Rb1, Rc2, Rd13), (Ra12, Rb1, Rc2, Rd14), (Ra12, Rb1, Rc2, Rd15), (Ra12, Rb1, Rc2, Rd17), (Ra12, Rb1, Rc2, Rd18), (Ra12, Rb1, Rc2, Rd19), (Ra12, Rb1, Rc2, Rd20), (Ra12, Rb1, Rc2, Rd22), (Ra12, Rb1, Rc2, Rd23), (Ra12, Rb1, Rc2, Rd24), (Ra12, Rb1, Rc2, Rd25), (Ra12, Rb1, Rc2, Rd27), (Ra12, Rb1, Rc2, Rd28), (Ra12, Rb1, Rc2, Rd29), (Ra12, Rb1, Rc3, Rd1), (Ra12, Rb1, Rc3, Rd2), (Ra12, Rb1,12Rc3, bRd3), (Ra12, Rb1, Rc3, Rd4), (Ra12, Rb1, Rc3, Rd5), (Ra12, Rb1, Rc3, Rd6), (Ra12, Rb1, Rc3, Rd7), (Ra12, Rb1, Rc3, Rd8), (Ra12, Rb1, Rc3, Rd9), (Ra12, Rb1, Rc3, Rd10), (Ra12, Rb1, Rc3, Rd11), (Ra12, Rb1, Rc3, Rd12), (Ra12, Rb1, Rc3, Rd13), (Ra12, Rb1, Rc3, Rd14), (Ra12, Rb1, Rc3, Rd15), (Ra12, Rb1, Rc3, Rd16), (Ra12, Rb1, Rc3, Rd17), (Ra12, Rb1, Rc3, Rd18), (Ra12, Rb1, Rc3, Rd19), (Ra12, Rb1, Rc3, Rd20), (Ra12, Rb1, Rc3, Rd21), (Ra12, Rb1, Rc3, Rd22), (Ra12, Rb1, Rc3, Rd23), (Ra12, Rb1, Rc3, Rd24), (Ra12, Rb1, Rc3, Rd25), (Ra12, Rb1, Rc3, Rd26), (Ra12, Rb1, Rc3, Rd27), (Ra12, Rb1, Rc3, Rd28), (Ra12, Rb1, Rc3, Rd29), (Ra12, Rb1, Rc4, Rd1), (Ra12, Rb1, Rc4, Rd2), (Ra12, Rb1, Rc4, Rd3), (Ra12, Rb1, Rc4, Rd4), (Ra12, Rb1, Rc4, Rd5), (Ra12, Rb1, Rc4, Rd6), (Ra12, Rb1, Rc4, Rd7), (Ra12, Rb1, Rc4, Rd8), (Ra12, Rb1, Rc4, Rd9), (Ra12, Rb1, Rc4, Rd10), (Ra12, Rb1, Rc4, Rd11), (Ra12, Rb1, Rc4, Rd12), (Ra12, Rb1, Rc4, Rd13), (Ra12, Rb1 , Rc4, Rd14), (Ra12, Rb1, Rc4, Rd15), (Ra12, Rb1, Rc4, Rd16), (Ra12, Rb1, Rc4, Rd17), (Ra12, Rb1, Rc4, Rd18), (Ra12, Rb1) , Rc4, Rd19), (Ra12, Rb1, Rc4, Rd20), (Ra12, Rb1, Rc4, Rd21), (Ra12, Rb1, Rc4, Rd22), (Ra12, Rb1, Rc4, Rd23), (Ra12, Rb1) , Rc4, Rd24), (Ra12,12Rb1, Rc4, Rd25), (Ra12, Rb1, Rc4, Rd27), (Ra12, Rb1, Rc4, Rd28), (Ra12, Rb1) , Rc4, Rd29), (Ra12, Rb1, Rc5, Rd2), (Ra12, Rb1, Rc5, Rd3), (Ra12, Rb1,) Rc5, Rd4), (Ra12, Rb1) , Rc5, Rd5), (Ra12, Rb1, Rc5, Rd6), (Ra12, Rb1, Rc5, Rd7), (Ra12, Rb1, Rc5, Rd8), (Ra12, Rb1, Rc5, Rd9), (Ra12, Rb1) , Rc5, Rd10), (Ra12, Rb1, Rc5, Rd11), (Ra12, Rb1, Rc5, Rd12), (Ra12, Rb1, Rc5, Rd13), (Ra12, Rb1, Rc5, Rd14), (Ra12, Rb1) , Rc5, dRd15), (Ra12, Rb1, Rc5, Rd16), (Ra12, Rb1, Rc5, Rd18), (Ra12, Rb1, Rc5, Rd19), (Ra12, Rb1) , Rc5, Rd20), (Ra12, Rb1, Rc5, Rd21), (Ra12, Rb1, Rc5, Rd23), (Ra12, Rb1, Rc5, (Rd24), (Ra12, Rb1, Rc5, Rd25), (Ra12, Rb1, Rc5, Rd26), (Ra12, Rb1, Rc5, Rd27), (Ra12, Rb1, Rc5, Rd28), (Ra12, Rb1, Rc5, Rd29), (Ra12, Rb2, Rc1, Rd1), (Ra12, Rb2, Rc1, Rd2), (Ra12, Rb2, Rc1, Rd3), (Ra12, Rb2, Rc1, Rd4), (Ra12, Rb2, Rc1, Rd5), (Ra12, Rb2, Rc1, Rd6), (Ra12, Rb2, Rc1, Rd7), (Ra12, Rb2, Rc1, Rd8), (Ra12, Rb2, Rc1, Rd9), (Ra12, Rb2, Rc1, Rd10), (Ra12, Rb2, Rc1, Rd11), (Ra12, Rb2, Rc1, Rd12), (Ra12, Rb2, Rc1, Rd13), (Ra12, Rb2, Rc1, Rd14), (Ra12, Rb2, Rc1, Rd15), (Ra12, Rb2, Rc1, Rd16), (Ra12, Rb2, Rc1, Rd17), (Ra12, Rb2, Rc1, Rd18), (Ra12, Rb2, Rc1, Rd19), (Ra12, Rb2, Rc1, Rd20), (Ra12, Rb2, Rc1, Rd21), (Ra12, Rb2, Rc1, Rd22), (Ra12, Rb2, Rc1, Rd23), (Ra12, Rb2, Rc1, Rd24), (Ra12, Rb2, Rc1, Rd25), (Ra12, Rb2, Rc1, Rd26), (Ra12, Rb2, Rc1, Rd27), (Ra12, Rb2, Rc1, Rd28), (Ra12, Rb2, Rc1, Rd29), (Ra12, Rb2, Rc2, Rd1), (Ra12, Rb2, Rc2, Rd2), (Ra12, Rb2, Rc2, Rd3), (Ra12, Rb2, Rc2, Rd4), (Ra12, Rb2, Rc2, Rd5), (Ra12, Rb2, Rc2, Rd6), (Ra12, Rb2, Rc2, Rd7), (Ra12, Rb2, Rc2, Rd8), (Ra12, Rb2, Rc2, Rd9), (Ra12, Rb2, Rc2, Rd10), (Ra12, Rb2, Rc2, Rd11), (Ra12, Rb2, Rc2, Rd12), (Ra12, Rb2, Rc2, Rd13), (Ra12, Rb2, Rc2, Rd14), (Ra12, Rb2, Rc2, Rd15), (Ra12, Rb2, Rc2, Rd16), (Ra12, Rb2, Rc2, Rd17), (Ra12, Rb2, Rc2, Rd18), (Ra12, Rb2, Rc2, Rd19), (Ra12, Rb2, Rc2, Rd20), (Ra12, Rb2, Rc2, Rd21), (Ra12, Rb2, Rc2, Rd22), (Ra12, Rb2, Rc2, Rd23), (Ra12, Rb2, Rc2, Rd24), (Ra12, Rb2, Rc2, Rd25), (Ra12, Rb2, Rc2, Rd26), (Ra12, Rb2, Rc2, Rd27), (Ra12, Rb2, Rc2, Rd28), (Ra12, Rb2, Rc2, Rd29), (Ra12, Rb2, Rc3, Rd1), (Ra12, Rb2, Rc3, Rd2), (Ra12, Rb2, Rc3, Rd3), (Ra12, Rb2, Rc3, Rd4), (Ra12, Rb2, Rc3, Rd5), (Ra12, Rb2, Rc3, Rd6), (Ra12, Rb2, Rc3, Rd7), (Ra12, Rb2, Rc3, Rd8), (Ra12, Rb2, Rc3, Rd9), (Ra12, Rb2, Rc3, Rd10), (Ra12, Rb2, Rc3, Rd11), (Ra12, Rb2, Rc3, Rd12), (Ra12, Rb2, Rc3, Rd13), (Ra12, Rb2, Rc3, Rd14), (Ra12, Rb2, Rc3, Rd15), (Ra12, Rb2, Rc3, Rd16), (Ra12, Rb2, Rc3, Rd17), (Ra12, Rb2, Rc3, Rd18), (Ra12, Rb2, Rc3, Rd19), (Ra12, Rb2, Rc3, Rd20), (Ra12, Rb2, Rc3, Rd21), (Ra12, Rb2, Rc3, Rd22), (Ra12, Rb2, Rc3, Rd23), (Ra12, Rb2, Rc3, Rd24), (Ra12, Rb2, Rc3, Rd25), (Ra12, Rb2, Rc3, Rd26), (Ra12, Rb2, Rc3, Rd27), (Ra12, Rb2, Rc3, Rd28), (Ra12, Rb2, Rc3, Rd29), (Ra12, Rb2, Rc4, Rd1), (Ra12, Rb2, Rc4, Rd2), (Ra12, Rb2, Rc4, Rd3), (Ra12, Rb2, Rc4, Rd4), (Ra12, Rb2, Rc4, Rd5), (Ra12, Rb2, Rc4, Rd6), (Ra12, Rb2, Rc4, Rd7), (Ra12, Rb2, Rc4, Rd8), (Ra12, Rb2, Rc4, Rd9), (Ra12, Rb2, Rc4, Rd10), (Ra12, Rb2, Rc4, Rd11), (Ra12, Rb2, Rc4, Rd12), (Ra12, Rb2, Rc4, Rd13 ), (Ra12, Rb2, Rc4, Rd14), (Ra12, Rb2, Rc4, Rd15), (Ra12, Rb2, Rc4, Rd16), (Ra12, Rb2, Rc4, Rd17), (Ra12, Rb2, Rc4, Rd18) ), (Ra12, Rb2, Rc4, Rd19), (Ra12, Rb2, Rc4, Rd20), (Ra12, Rb2, Rc4, Rd21), (Ra12, Rb2, Rc4, Rd22), (Ra12, Rb2, Rc4, Rd23) ), (Ra12, Rb2, Rc4, Rd24), (Ra12, Rb2, Rc4, Rd25), (Ra12, Rb2, Rc4, Rd26), (Ra12, Rb2, Rc4, Rd27), (Ra12, Rb2, Rc4, Rd28) ), (Ra12, Rb2, Rc4, Rd29), (Ra12, Rb2, Rc5, Rd1), (Ra12, Rb2, Rc5, Rd2), (Ra12, Rb2, Rc5, Rd3), (Ra12, Rb2, Rc5, Rd4) ), (Ra12, Rb2, Rc5, Rd5), (Ra12, Rb2, Rc5, Rd6), (Ra12, Rb2, Rc5, Rd7), (Ra12, Rb2, Rc5, Rd8), (Ra12, Rb2, Rc5, Rd9) ), (Ra12, Rb2, Rc5, Rd10), (Ra12, Rb2, Rc5, Rd11), (Ra12, Rb2, Rc5, Rd12), (Ra12, Rb2, Rc5, Rd13), (Ra12, Rb2, Rc5, Rd14) ), (Ra12, Rb2, Rc5, Rd15), (Ra12, Rb2, Rc5, Rd17), (Ra12, Rb2, Rc5, Rd18), (Ra12, Rb2, Rc5, Rd19) ), (Ra12, Rb2, Rc5, Rd20) , (Ra12, Rb2, Rc5, Rd21), (Ra12, Rb2, Rc5, Rd22), (Ra12, Rb2, Rc5, Rd23), (Ra12, Rb2, Rc5, Rd24), (Ra12, Rb2, Rc5, Rd25) , (Ra12, Rb2, cRc5, Rd26), (Ra12, Rb2, Rc5, Rd27), (Ra12, Rb2, Rc5, Rd28), (Ra12, Rb2, Rc5, Rd29), (Ra13, Rb1, Rc1, Rd1) , (Ra13, Rb1, Rc1, Rd2), (Ra13, Rb1, Rc1, Rd3), (Ra13, Rb1, Rc1, Rd4), (Ra13, Rb1, Rc1, Rd5), (Ra13, Rb1, Rc1, Rd6) , (Ra13, Rb1, Rc1, Rd7), (Ra13, Rb1, Rc1, Rd8), (Ra13, Rb1, Rc1, Rd9), (Ra13, Rb1, Rc1, Rd10), (Ra13, Rb1, Rc1, Rd11) , (Ra13, Rb1, Rc1, Rd12), (Ra13, Rb1, Rc1, Rd13), (Ra13, Rb1, Rc1, Rd14), (Ra13, Rb1, Rc1, Rd15), (Ra13, Rb1, Rc1, Rd16) , (Ra13, Rb1, Rc1, Rd17), (Ra13, Rb1, Rc1, Rd18), (Ra13, Rb1, Rc1, Rd19), (Ra13, Rb1, Rc1, Rd20), (Ra13, Rb1, Rc1, Rd21) , (Ra13, Rb1, Rc1, Rd22), (Ra13, Rb1, Rc1, Rd23), (Ra13, Rb1, Rc1, Rd24), (Ra13, Rb1, Rc1, Rd25), (Ra13, Rb1, Rc1, Rd26) , (Ra13, Rb1, Rc1, Rd27) (Ra13, Rb1, Rc1, Rd28), (Ra13, Rb1, Rc1, Rd29), (Ra13, Rb1, Rc2, Rd1), (Ra13, Rb1, Rc2, Rd2), (Ra13, Rb1, Rc2, Rd3), (Ra13, Rb1, Rc2, Rd4), (Ra13, Rb1, Rc2, Rd6), (Ra13, Rb1, Rc2, Rd7), (Ra13, Rb1, Rc2, Rd8), (Ra13, Rb1, Rc2, Rd9), (Ra13, Rb1, Rc2, Rd11), (Ra13, Rb1, Rc2, Rd12), (Ra13, Rb1, Rc2, Rd13), (Ra13, Rb1, Rc2, Rd14), (Ra13, Rb1, Rc2, Rd16), (Ra13, Rb1, Rc2, Rd17), (Ra13, Rb1, Rc2, Rd18), (Ra13, Rb1, Rc2, Rd19), (Ra13, Rb1, Rc2, Rd20), (Ra13, Rb1, Rc2, Rd21),

(Ra13, Rb1, Rc2, Rd22), (Ra13, Rb1, Rc2, Rd24), (Ra13, Rb1, Rc2, Rd25), (Ra13, dRb1, Rc2, Rd26), (Ra13, Rb1, Rc2, Rd27), (Ra13, Rb1, Rc2, Rd29), (Ra13, Rb1, Rc3, Rd1), (Ra13, Rb1, (Rc3, Rd2), (Ra13, Rb1, Rc3, Rd3), (Ra13, Rb1, Rc3, Rd4), (Ra13, Rb1, Rc3, Rd5), (Ra13, Rb1, Rc3, Rd6), (Ra13, Rb1, Rc3, Rd7), (Ra13, Rb1, Rc3, Rd8), (Ra13, Rb1, Rc3, Rd9), (Ra13, Rb1, Rc3, Rd10), (Ra13, Rb1, Rc3, Rd11), (Ra13, Rb1, Rc3, Rd12), (Ra13, Rb1, Rc3, Rd13), (Ra13, Rb1, Rc3, Rd14), (Ra13, Rb1, Rc3, Rd15), (Ra13, Rb1, Rc3, Rd16), (Ra13, Rb1, Rc3, Rd17), (Ra13, Rb1, Rc3, Rd18), (Ra13, Rb1, Rc3, Rd19), (Ra13, Rb1, Rc3, Rd20), (Ra13, Rb1, Rc3, Rd21), (Ra13, Rb1, Rc3, Rd22), (Ra13, Rb1, Rc3, Rd23), (Ra13, Rb1, Rc3, Rd24), (Ra13, Rb1, Rc3, Rd25), (Ra13, Rb1, Rc3, Rd26), (Ra13, Rb1, Rc3, Rd27), (Ra13, Rb1, Rc3,3Rd28) (Ra13, Rb1, Rc3, Rd29), (Ra13, Rb1, Rc4, Rd1), (Ra13, Rb1, Rc4, Rd2), (Ra13, Rb1, 、 Rc4, Rd3), (Ra13, Rb1, Rc4, Rd4), (Ra13, Rb1, Rc4, Rd5), (Ra13, Rb1, Rc4, Rd7), (Ra13, Rb1, Rc4, Rd8), (Ra13, Rb1, Rc4, Rd9), (Ra13, Rb1, Rc4, Rd10), (Ra13, Rb1, Rc4, Rd11), (Ra13, Rb1, Rc4, Rd12), (Ra13, Rb1, Rc4, Rd13), (Ra13, Rb1, Rc4, Rd14), (Ra13, Rb1, Rc4, Rd15), (Ra13, Rb1, Rc4, Rd16), (Ra13, Rb1, Rc4, Rd17), (Ra13, Rb1, Rc4, Rd18), (Ra13, Rb1, Rc4, Rd19), (Ra13, Rb1, Rc4, Rd20), (Ra13, Rb1, Rc4, Rd21), (Ra13, Rb1, Rc4, Rd22), (Ra13, Rb1, Rc4, Rd23), (Ra13, Rb1, Rc4, Rd24), (Ra13, Rb1, Rc4, Rd25), (Ra13, Rb1, Rc4, Rd27), (Ra13, Rb1, Rc4, Rd27), (Ra13, Rb1, Rc4, Rd28), (Ra13, Rb1, Rc4, Rd29), (Ra13, Rb1, Rc5, Rd1), (Ra13, Rb1, Rc5, Rd2), (Ra13, Rb1, Rc5, Rd3), (Ra13, Rb1, Rc5, Rd4), (Ra13, Rb1, Rc5, Rd5), (Ra13, Rb1, Rc5, Rd6), (Ra13, Rb1, Rc5, Rd7), (Ra13, Rb1, Rc5, Rd8), (Ra13, Rb1, Rc5, Rd9), (Ra13, Rb1, Rc5, Rd10), (Ra13, Rb1, Rc5, Rd11), (Ra13, Rb1, Rc5, Rd12), (Ra13, Rb1, Rc5, Rd13), (Ra13, Rb1, Rc5, Rd14), (Ra13, Rb1, Rc5, Rd15), (Ra13, Rb1, Rc5, Rd16), (Ra13, Rb1, Rc5, Rd17), (Ra13, Rb1, Rc5, Rd18), (Ra13, Rb1, Rc5, Rd19), (Ra13, Rb1, Rc5, Rd20), (Ra13, Rb1, Rc5, Rd21), (Ra13, Rb1, Rc5, Rd22), (Ra13, Rb1, Rc5, Rd23), (Ra13, Rb1, Rc5, Rd24), (Ra13, Rb1, Rc5, Rd25), (Ra13, Rb1, Rc5, Rd26), (Ra13, Rb1, Rc5, Rd27), (Ra13, Rb1, Rc5, Rd28), (Ra13, Rb1, Rc5, Rd29), (Ra13, Rb2, Rc1, Rd1), (Ra13, Rb2, Rc1, Rd2), (Ra13, Rb2, Rc1, Rd3), (Ra13, Rb2, Rc1, Rd4), (Ra13, Rb2, Rc1, Rd5), (Ra13, Rb2, Rc1, Rd6), (Ra13, Rb2, Rc1, Rd7), (Ra13, Rb2, Rc1, Rd8), (Ra13, Rb2, Rc1, Rd9), (Ra13, Rb2, Rc1, Rd10), (Ra13, Rb2, Rc1, Rd11), (Ra13, Rb2, Rc1, Rd12), (Ra13, Rb2, Rc1, Rd13), (Ra13, Rb 2, Rc1, Rd14), (Ra13, Rb2, Rc1, Rd15), (Ra13, Rb2, Rc1, Rd16), (Ra13, Rb2, Rc1, Rd17), (Ra13, Rb2, Rc1, Rd18), (Ra13, Rb2, Rc1, Rd19), (Ra13, Rb2, Rc1, Rd20), (Ra13, Rb2, Rc1, Rd21), (Ra13, Rb2, Rc1, Rd22), (Ra13, Rb2, Rc1, Rd23), (Ra13, Rb2, Rc1, Rd24), (Ra13, Rb2, Rc1, Rd26), (Ra13, Rb2, Rc1, Rd27), (Ra13, Rb2, Rc1, Rd28), (Ra13, Rb2, Rc1, Rd29), (Ra13, Rb2, Rc2, Rd1), (Ra13, Rb2, Rc2, Rd2), (Ra13, Rb2, Rc2, Rd3), (Ra13, Rb2, Rc2, Rd4), (Ra13, Rb2, Rc2, Rd5), (Ra13, Rb2, Rc2, Rd6), (Ra13, Rb2, Rc2, Rd7), (Ra13, Rb2, Rc2, Rd8), (Ra13, Rb2, Rc2, Rd9), (Ra13, Rb2, Rc2, Rd10), (Ra13, Rb2, Rc2, Rd11), (Ra13, Rb2, Rc2, Rd12), (Ra13, Rb2, Rc2, Rd13), (Ra13, Rb2, Rc2, Rd14), (Ra13, Rb2, Rc2, Rd15), (Ra13, Rb2, Rc2, Rd16), (Ra13, Rb2, Rc2, Rd17), (Ra13, Rb2, Rc2, Rd18), (Ra13, Rb2, Rc2, Rd19), (Ra13, Rb2, Rc2, Rd20), (Ra13, Rb2 , Rc2, Rd21), (Ra13, Rb2, Rc2, Rd22), (Ra13, Rb2, Rc2, Rd23), (Ra13, Rb2, Rc2, Rd24), (Ra13, Rb2, Rc2, Rd25), (Ra13, Rb2 , Rc2, Rd26), (Ra13, Rb2, Rc2, Rd28), (Ra13, Rb2, Rc2, Rd29), (Ra13, Rb2, Rc3, Rd1), (Ra13, Rb2) , Rc3, Rd2), (Ra13, Rb2, Rc3, Rd3), (Ra13, Rb2, Rc3, Rd4), (Ra13, Rb2, Rc3, Rd5), (Ra13, Rb2, Rc3, Rd6), (Ra13, Rb2) , Rc3, Rd7), (Ra13, Rb2, Rc3, Rd8), (Ra13, Rb2, Rc3, Rd9), (Ra13, Rb2, Rc3, Rd10), (Ra13, Rb2, Rc3, Rd11), (Ra13, Rb2) , Rc3, Rd12), (Ra13, Rb2, Rc3, Rd13), (Ra13, Rb2, Rc3, Rd15), (Ra13, Rb2, Rc3, Rd16), (Ra13, Rb2) , Rc3, Rd17), (Ra13, Rb2, Rc3, Rd18), (Ra13, Rb2, Rc3, Rd20), (Ra13, Rb2, Rc3, Rd21), (Ra13, Rb2) , Rc3, Rd22), (Ra13, Rb2, Rc3, Rd23), (Ra13, Rb2, Rc3, Rd25), (Ra13, Rb2, Rc3, Rd26), (Ra13, Rb2) , Rc3, Rd27), (Ra13, Rb2, Rc3, Rd28), (Ra13, Rb2, Rc3, Rd29), (Ra13, Rb2, Rc4, Rd1), (Ra13, Rb2, Rc4, Rd2), (Ra13, Rb2, Rc4, Rd3), (Ra13, Rb2, Rc4, Rd4), (Ra13, Rb2, Rc4, Rd5), (Ra13, Rb2, Rc4, Rd6), (Ra13, Rb2, Rc4, Rd7), (Ra13, Rb2, Rc4, Rd8), (Ra13, Rb2, Rc4, Rd9), (Ra13, Rb2, Rc4, Rd10), (Ra13, Rb2, Rc4, Rd11), (Ra13, Rb2, Rc4, Rd12), (Ra13, Rb2, Rc4, Rd13), (Ra13, Rb2, Rc4, Rd14), (Ra13, Rb2, Rc4, Rd15), (Ra13, Rb2, Rc4, Rd16), (Ra13, Rb2, Rc4, Rd17), (Ra13, Rb2, Rc4, Rd18), (Ra13, Rb2, Rc4, Rd19), (Ra13, Rb2, Rc4, Rd20), (Ra13, Rb2, Rc4, Rd21), (Ra13, Rb2, Rc4, Rd22), (Ra13, Rb2, Rc4, Rd23), (Ra13, Rb2, Rc4, Rd24), (Ra13, Rb2, Rc4, Rd25), (Ra13, Rb2, Rc4, Rd26), (Ra13, Rb2, Rc4, Rd27), (Ra13, Rb2, Rc4, Rd28), (Ra13, Rb2, Rc4, Rd29), (Ra13, Rb2, Rc5, Rd1), (Ra13, Rb2, Rc5, Rd2), (Ra13, Rb2, Rc5, Rd3), (Ra13, Rb2, Rc5, Rd4), (Ra13, Rb2, Rc5, Rd5), (Ra13, Rb2, Rc5, Rd6), (Ra13, Rb2, Rc5, Rd7), (Ra13, Rb2, Rc5, Rd8), (Ra13, Rb2, Rc5, Rd9), (Ra13, Rb2, Rc5, Rd10), (Ra13, Rb2, Rc5, Rd11), (Ra13, Rb2, Rc5, Rd12), (Ra13, Rb2, Rc5, Rd13), (Ra13, Rb2, Rc5, Rd14), (Ra13, Rb2, Rc5, Rd15), (Ra13, Rb2, Rc5, Rd16), (Ra13, Rb2, Rc5, Rd17), (Ra13, Rb2, Rc5, Rd18), (Ra13, Rb2, Rc5, Rd19), (Ra13, Rb2, Rc5, Rd20), (Ra13, Rb2, Rc5, Rd21), (Ra13, Rb2, Rc5, Rd22), (Ra13, Rb2, Rc5, Rd23), (Ra13, Rb2, Rc5, Rd24), (Ra13, Rb2, Rc5, Rd25), (Ra13, Rb2, Rc5, Rd26), (Ra13, Rb2, Rc5, Rd27), (Ra13, Rb2, Rc5, Rd28), (Ra13, Rb2, Rc5, Rd29), (Ra14, Rb1, Rc1, Rd1), (Ra14, Rb1, Rc1, Rd2), (Ra14, Rb1, Rc1, Rd3), (Ra14, Rb1, Rc1, Rd4), (Ra14, Rb1, Rc1, Rd5), (Ra14, Rb1, Rc1, Rd6), (Ra14, Rb1, Rc1, Rd7), (Ra14, Rb1, Rc1, Rd8), (Ra14, Rb1, Rc1, Rd9), (Ra14, Rb1, Rc1, Rd10), (Ra14, Rb1, Rc1, Rd11), (Ra14, Rb1, Rc1, Rd12), (Ra14, Rb1, Rc1, Rd1 3), (Ra14, Rb1, Rc1, Rd14), (Ra14, Rb1, Rc1, Rd15), (Ra14, Rb1, Rc1, Rd16), (Ra14, Rb1, Rc1, Rd17), (Ra14, Rb1, Rc1, Rd18), (Ra14, Rb1, Rc1, Rd19), (Ra14, Rb1, Rc1, Rd20), (Ra14, Rb1, Rc1, Rd21), (Ra14, Rb1, Rc1, Rd22), (Ra14, Rb1, Rc1, Rd23), (Ra14, Rb1, Rc1, Rd24), (Ra14, Rb1, Rc1, Rd25), (Ra14, Rb1, Rc1, Rd26), (Ra14, Rb1, Rc1, Rd27), (Ra14, Rb1, Rc1, Rd28), (Ra14, Rb1, Rc1, Rd29), (Ra14, Rb1, Rc2, Rd1), (Ra14, Rb1, Rc2, Rd2), (Ra14, Rb1, Rc2, Rd3), (Ra14, Rb1, Rc2, Rd4), (Ra14, Rb1, Rc2, Rd5), (Ra14, Rb1, Rc2, Rd6), (Ra14, Rb1, Rc2, Rd7), (Ra14, Rb1, Rc2, Rd8), (Ra14, Rb1, Rc2, Rd9), (Ra14, Rb1, Rc2, Rd10), (Ra14, Rb1, Rc2, Rd11), (Ra14, Rb1, Rc2, Rd12), (Ra14, Rb1, Rc2, Rd13), (Ra14, Rb1, Rc2, Rd14), (Ra14, Rb1, Rc2, Rd15), (Ra14, Rb1, Rc2, Rd16), (Ra14, Rb1, Rc2, Rd17), (Ra14, Rb1, Rc2, Rd18), (Ra14, Rb1, Rc2, Rd19), (Ra14, Rb1, Rc2, Rd20 ), (Ra14, Rb1, Rc2, Rd21), (Ra14, Rb1, Rc2, Rd22), (Ra14, Rb1, Rc2, Rd23), (Ra14, Rb1, Rc2, Rd24), (Ra14, Rb1, Rc2, Rd25) ), (Ra14, Rb1, Rc2, Rd26), (Ra14, Rb1, Rc2, Rd27), (Ra14, Rb1, Rc2, Rd28), (Ra14, Rb1, Rc2, Rd29), (Ra14, Rb1, Rc3, Rd1 ), (Ra14, Rb1, Rc3, Rd2), (Ra14, Rb1, Rc3, Rd3), (Ra14, Rb1, Rc3, Rd4), (Ra14, Rb1, Rc3, Rd5), (Ra14, Rb1, Rc3, Rd6) ), (Ra14, Rb1, Rc3, Rd7), (Ra14, Rb1, Rc3, Rd8), (Ra14, Rb1, Rc3, Rd9), (Ra14, Rb1, Rc3, Rd10), (Ra14, Rb1, Rc3, Rd11) ), (Ra14, Rb1, Rc3, Rd12), (Ra14, Rb1, Rc3, Rd13), (Ra14, Rb1, Rc3, Rd14), (Ra14, Rb1, Rc3, Rd15), (Ra14, Rb1, Rc3, Rd16) ), (Ra14, Rb1, Rc3, Rd17), (Ra14, Rb1, Rc3, Rd18), (Ra14, Rb1, Rc3, Rd19), (Ra14, Rb1, Rc3, Rd20), (Ra14, Rb1, Rc3, Rd21) ), (Ra14, Rb1, Rc3, Rd22), (Ra14, Rb1, Rc3, Rd23), (Ra14, Rb1, Rc3, Rd24), (Ra14, Rb1, Rc3, Rd25), (Ra14, Rb1, Rc3, Rd26 ), (Ra14, Rb1, Rc3, Rd27) , (Ra14, Rb1, Rc3, Rd28), (Ra14, Rb1, Rc3, Rd29), (Ra14, Rb1, Rc4, Rd1), (Ra14, Rb1, Rc4, Rd2), (Ra14, Rb1, Rc4, Rd3) , (Ra14, Rb1, Rc4, Rd4), (Ra14, Rb1, Rc4, Rd5), (Ra14, Rb1, Rc4, Rd6), (Ra14, Rb1, Rc4, Rd7), (Ra14, Rb1, Rc4, Rd8) , (Ra14, Rb1, Rc4, Rd9), (Ra14, Rb1, Rc4, Rd10), (Ra14, Rb1, Rc4, Rd11), (Ra14, Rb1, Rc4, Rd12), (Ra14, Rb1, Rc4, Rd13) , (Ra14, Rb1, Rc4, Rd14), (Ra14, Rb1, Rc4, Rd15), (Ra14, Rb1, Rc4, Rd16), (Ra14, Rb1, Rc4, Rd17), (Ra14, Rb1, Rc4, Rd18) , (Ra14, Rb1, Rc4, Rd19), (Ra14, Rb1, Rc4, Rd20), (Ra14, Rb1, Rc4, Rd21), (Ra14, Rb1, Rc4, Rd22), (Ra14, Rb1, Rc4, Rd23) , (Ra14, Rb1, Rc4, Rd24), (Ra14, Rb1, Rc4, Rd25), (Ra14, Rb1, Rc4, Rd26), (Ra14, Rb1, Rc4, Rd27), (Ra14, Rb1, Rc4, Rd28) , (Ra14, Rb1, Rc4, Rd29), (Ra14, Rb1, Rc5, Rd1), (Ra14, Rb1, Rc5, Rd2), (Ra14, Rb1, Rc5, Rd3), (Ra14, Rb1, Rc5, Rd4) , (Ra14, Rb1, Rc5, Rd5), (Ra 14, Rb1, Rc5, Rd6), (Ra14, Rb1, Rc5, Rd7), (Ra14, Rb1, Rc5, Rd8), (Ra14, Rb1, Rc5, Rd9), (Ra14, Rb1, Rc5, Rd10), (Ra14, Rb1, Rc5, 11Rd11), (Ra14, Rb1, Rc5, Rd12), (Ra14, Rb1, Rc5, Rd13), (Ra14, Rb1, Rc5, Rd14), (Ra14, Rb1, Rc5, Rd15), (Ra14, Rb1, Rc5, 16Rd16), (Ra14, Rb1, Rc5, Rd17), (Ra14, Rb1, Rc5, Rd18), (Ra14, Rb1, Rc5, Rd19), (Ra14, Rb1, Rc5, Rd20), (Ra14, Rb1, Rc5, Rd21), (Ra14, Rb1, Rc5, Rd22), (Ra14, Rb1, Rc5, Rd23), (Ra14, Rb1, Rc5, Rd24), (Ra14, Rb1, Rc5, Rd25), (Ra14, Rb1, Rc5, Rd26), (Ra14, Rb1, Rc5, Rd27), (Ra14, Rb1, Rc5, Rd28), (Ra14, Rb1, Rc5, Rd29), (Ra14, Rb2, Rc1, Rd1), Ra14, Rb2, Rc1, Rd2),

(Ra14, Rb2, Rc1, Rd3), (Ra14, Rb2, Rc1, Rd5), (Ra14, Rb2, Rc1, Rd6), (Ra14, Rb2, Rc1, Rd7), (Ra14, Rb2, Rc1, Rd8), (Ra14, Rb2, Rc1, Rd9), (Ra14, Rb2, Rc1, Rd10), (Ra14, Rb2, Rc1, Rd11), (Ra14, Rb2, Rc1, Rd12), (Ra14, Rb2, Rc1, Rd13), (Ra14, Rb2, Rc1, Rd15), (Ra14, Rb2, Rc1, Rd16), (Ra14, Rb2, Rc1, Rd17), (Ra14, Rb2, Rc1, Rd18), (Ra14, Rb2, Rc1, Rd20), (Ra14, Rb2, Rc1, Rd21), (Ra14, Rb2, Rc1, Rd22), (Ra14, Rb2, Rc1, Rd23), (Ra14, Rb2, Rc1, Rd25), (Ra14, Rb2, Rc1, Rd26), (Ra14, Rb2, Rc1, Rd27), (Ra14, Rb2, Rc1, Rd28), (Ra14, Rb2, Rc1, Rd29), (Ra14, Rb2, Rc2, Rd1), (Ra14, Rb2, Rc2, Rd2), (Ra14, Rb2, Rc2, Rd3), (Ra14, Rb2, Rc2, Rd4), (Ra14, Rb2, Rc2, Rd6), (Ra14, Rb2, Rc2, Rd7), (Ra14, Rb2, Rc2, Rd8), (Ra14, Rb2, Rc2, Rd9), (Ra14, Rb2, Rc2, Rd10), (Ra14, Rb2, Rc2, Rd11), (Ra14, Rb2, Rc2, Rd12), (Ra14, Rb2, Rc2, Rd13), (Ra14, Rb2, Rc2, Rd14), (Ra14, Rb2, Rc2, Rd15), (Ra14, Rb2, Rc2, Rd16), (Ra14, Rb2, Rc2, Rd17), (Ra14, Rb2, Rc2, Rd18), (Ra14, Rb2, Rc2, Rd19), (Ra14, Rb2, Rc2, Rd20), (Ra14, Rb2, Rc2, Rd21), (Ra14, Rb2, Rc2, Rd22), (Ra14, Rb2, Rc2, Rd23), (Ra14, Rb2, Rc2, Rd24), (Ra14, Rb2, Rc2, Rd25), (Ra14, Rb2, Rc2, Rd26), (Ra14, Rb2, Rc2, Rd27), (Ra14, Rb2, Rc2, Rd28), (Ra14, Rb2, Rc2, Rd29), (Ra14, Rb2, Rc3, Rd1), (Ra14, Rb2, Rc3, Rd2), (Ra14, Rb2, Rc3, Rd3), (Ra14, Rb2, Rc3, Rd4), (Ra14, Rb2, Rc3, Rd5), (Ra14, Rb2, Rc3, Rd6), (Ra14, Rb2, Rc3, Rd7), (Ra14, Rb2, Rc3, Rd8), (Ra14, Rb2, Rc3, Rd9), (Ra14, Rb2, Rc3, Rd10), (Ra14, Rb2, Rc3, Rd11), (Ra14, Rb2, Rc3, Rd12), (Ra14, Rb2, Rc3, Rd13), (Ra14, Rb2, Rc3, Rd14), (Ra14, Rb2, Rc3, Rd15), (Ra14, Rb2, Rc3, Rd16), (Ra14, Rb2, Rc3, Rd17), (Ra14, Rb2, Rc3, Rd18), (Ra14, Rb2, Rc3, Rd19), (Ra14, Rb2, Rc3, Rd20), (Ra14, Rb2, Rc3, Rd21), (Ra14, Rb2, Rc3, Rd22), (Ra14, Rb2, Rc3, Rd23), (Ra14, Rb2, Rc3, Rd24), (Ra14, Rb2, Rc3, Rd25), (Ra14, Rb2, Rc3, Rd26), (Ra14, Rb2, Rc3, Rd27), (Ra14, Rb2, Rc3, Rd28), (Ra14, Rb2, Rc3, Rd29), (Ra14, Rb2, Rc4, Rd1), (Ra14, Rb2, Rc4, Rd2), (Ra14, Rb2, Rc4, Rd3), (Ra14, Rb2, Rc4, Rd4), (Ra14, Rb2, Rc4, Rd5), (Ra14, Rb2, Rc4, Rd6), (Ra14, Rb2, Rc4, Rd7), (Ra14, Rb2, Rc4, Rd8), (Ra14, Rb2, Rc4, Rd9), (Ra14, Rb2, Rc4, Rd10), (Ra14, Rb2, Rc4, Rd11), (Ra14, Rb2, Rc4, Rd12), (Ra14, Rb2, Rc4, Rd13), (Ra14, Rb2, Rc4, Rd14), (Ra14, Rb2, Rc4, Rd15), (Ra14, Rb2, Rc4, Rd16), (Ra14, Rb2, Rc4, Rd17), (Ra14, Rb2, Rc4, Rd18), (Ra14, Rb2, Rc4, Rd19), (Ra14, Rb2, Rc4, Rd20), (Ra14, Rb2, Rc4, Rd21), (Ra14, Rb2, Rc4, Rd22), (Ra14, Rb2, Rc4, Rd23), (Ra14, Rb2, Rc4, Rd24), (Ra14, Rb2, Rc4, Rd25), (Ra14, Rb2, Rc4, Rd26), (Ra14, Rb2, Rc4, Rd27), (Ra14, Rb2, Rc4, Rd28), (Ra14, Rb2, Rc4, Rd29), (Ra14, Rb2, Rc5, Rd1), (Ra14, Rb2, Rc5, Rd2), (Ra14, Rb2, Rc5, Rd3), (Ra14, Rb2, Rc5, Rd4), (Ra14, Rb2, Rc5, Rd5), (Ra14, Rb2, Rc5, Rd6), (Ra14, Rb2, Rc5, Rd7), (Ra14, Rb2, Rc5, Rd8), (Ra14, Rb2, Rc5, Rd9), (Ra14, Rb2, Rc5, Rd10), (Ra14, Rb2, Rc5, Rd11), (Ra14, Rb2, Rc5, Rd12), (Ra14, Rb2, Rc5, Rd13), (Ra14, Rb2, Rc5, Rd14), (Ra14, Rb2, Rc5, Rd15), (Ra14, Rb2, Rc5, Rd16), (Ra14, Rb2, Rc5, Rd17), (Ra14, Rb2, Rc5, Rd18), (Ra14, Rb2, Rc5, Rd19), (Ra14, Rb2, Rc5, Rd20), (Ra14, Rb2, Rc5, Rd21), (Ra14, Rb2, Rc5, Rd22), (Ra14, Rb2, Rc5, Rd23), (Ra14, Rb2, Rc5, Rd24), (Ra14, Rb2, Rc5, Rd25), (Ra14, Rb2, Rc5, Rd26), (Ra14, Rb2, Rc5, Rd27), (Ra14, Rb2, Rc5, Rd28), (Ra14, Rb2, Rc5, Rd29), (Ra15, Rb1, Rc1, Rd1), (Ra15, Rb 1, Rc1, Rd2), (Ra15, Rb1, Rc1, Rd3), (Ra15, Rb1, Rc1, Rd4), (Ra15, Rb1, Rc1, Rd5), (Ra15, Rb1, Rc1, Rd6), (Ra15, Rb1, Rc1, Rd7), (Ra15, Rb1, Rc1, Rd8), (Ra15, Rb1, Rc1, Rd9), (Ra15, Rb1, Rc1, Rd10), (Ra15, Rb1, Rc1, Rd11), (Ra15, Rb1, Rc1, Rd12), (Ra15, Rb1, Rc1, Rd13), (Ra15, Rb1, Rc1, Rd14), (Ra15, Rb1, Rc1, Rd15), (Ra15, Rb1, Rc1, Rd16), (Ra15, Rb1, Rc1, Rd17), (Ra15, Rb1, Rc1, Rd18), (Ra15, Rb1, Rc1, Rd19), (Ra15, Rb1, Rc1, Rd20), (Ra15, Rb1, Rc1, Rd21), (Ra15, Rb1, Rc1, Rd22), (Ra15, Rb1, Rc1, Rd23), (Ra15, Rb1, Rc1, Rd24), (Ra15, Rb1, Rc1, Rd25), (Ra15, Rb1, Rc1, Rd26), (Ra15, Rb1, Rc1, Rd27), (Ra15, Rb1, Rc1, Rd28), (Ra15, Rb1, Rc1, Rd29), (Ra15, Rb1, Rc2, Rd1), (Ra15, Rb1, Rc2, Rd2), (Ra15, Rb1, Rc2, Rd3), (Ra15, Rb1, Rc2, Rd4), (Ra15, Rb1, Rc2, Rd6), (Ra15, Rb1, Rc2, Rd6), (Ra15, Rb1, Rc2, Rd7), (Ra15, Rb1, Rc2, Rd8), (Ra15, Rb1, Rc2, Rd9), (Ra15, Rb1, Rc2, Rd10), (Ra15, Rb1, Rc2, Rd11), (Ra15, Rb1, Rc2, Rd12), (Ra15, Rb1, Rc2, Rd13), (Ra15, Rb1, Rc2, Rd14), (Ra15, Rb1, Rc2, Rd15), (Ra15, Rb1, Rc2, Rd16), (Ra15, Rb1, Rc2, Rd17), (Ra15, Rb1, Rc2, Rd18), (Ra15, Rb1, Rc2, Rd19), (Ra15, Rb1, Rc2, Rd20), (Ra15, Rb1, Rc2, Rd21), (Ra15, Rb1, Rc2, Rd22), (Ra15, Rb1, Rc2, Rd23), (Ra15, Rb1, Rc2, Rd24), (Ra15, Rb1, Rc2, Rd25), (Ra15, Rb1, Rc2, Rd26), (Ra15, Rb1, Rc2, Rd27), (Ra15, Rb1, Rc2, Rd28), (Ra15, Rb1, Rc2, Rd29), (Ra15, Rb1, Rc3, Rd1), (Ra15, Rb1, Rc3, Rd3), (Ra15, Rb1, Rc3, Rd3), (Ra15, Rb1, Rc3, Rd4), (Ra15, Rb1, Rc3, Rd5), (Ra15, Rb1, Rc3, Rd6), (Ra15, Rb1, Rc3, Rd7), (Ra15, Rb1, Rc3, Rd8), (Ra15, Rb1, Rc3, Rd9), (Ra15, Rb1, Rc3, Rd10), (Ra15, Rb1, Rc3, Rd11), (Ra15, Rb1, Rc3, Rd12), (Ra15, Rb1, Rc3, Rd13), (Ra15, Rb1, Rc3, Rd14), (Ra15, Rb1, Rc3, Rd15), (Ra15, Rb1, Rc3, Rd16), (Ra15, Rb1, Rc3, Rd17), (Ra15, Rb1, Rc3, Rd18), (Ra15, Rb1, Rc3, Rd19), (Ra15, Rb1, Rc3, Rd20), (Ra15, Rb1, Rc3, Rd21), (Ra15, Rb1, Rc3, Rd22), (Ra15, Rb1, Rc3, Rd23), (Ra15, Rb1, Rc3, Rd24), (Ra15, Rb1, Rc3, Rd25), (Ra15, Rb1, Rc3, Rd26), (Ra15, Rb1, Rc3, Rd27), (Ra15, Rb1, Rc3, Rd28), (Ra15, Rb1, Rc3, Rd29), (Ra15, Rb1, Rc4, Rd1), (Ra15, Rb1, Rc4, Rd2), (Ra15, Rb1, Rc4, Rd3), (Ra15, Rb1, Rc4, Rd4), (Ra15, Rb1, Rc4, Rd5), (Ra15, Rb1, Rc4, Rd6), (Ra15, Rb1, Rc4, Rd7), (Ra15, Rb1, Rc4, Rd8), (Ra15, Rb1, Rc4, Rd9), (Ra15, Rb1, Rc4, Rd10), (Ra15, Rb1, Rc4, Rd11), (Ra15, Rb1, Rc4, Rd12), (Ra15, Rb1, Rc4, Rd13), (Ra15, Rb1, Rc4, Rd14), (Ra15, Rb1, Rc4, Rd15), (Ra15, Rb1, Rc4, Rd16), (Ra15, Rb1, Rc4, Rd17), (Ra15, Rb1, Rc4, Rd18), (Ra15, Rb1, Rc4, Rd19), (Ra15, Rb1, Rc4, Rd20), (Ra15, Rb1, Rc4, Rd21), (Ra15, Rb1, Rc4, Rd22), (Ra15, Rb1, Rc4, R d23), (Ra15, Rb1, Rc4, Rd24), (Ra15, Rb1, Rc4, Rd25), (Ra15, Rb1, Rc4, Rd26), (Ra15, Rb1, Rc4, Rd27), (Ra15, Rb1, Rc4, Rd28), (Ra15, Rb1, Rc4, Rd29), (Ra15, Rb1, Rc5, Rd1), (Ra15, Rb1, Rc5, Rd2), (Ra15, Rb1, Rc5, Rd3), (Ra15, Rb1, Rc5, Rd4), (Ra15, Rb1, Rc5, Rd5), (Ra15, Rb1, Rc5, Rd6), (Ra15, Rb1, Rc5, Rd7), (Ra15, Rb1, Rc5, Rd8), (Ra15, Rb1, Rc5, Rd9), (Ra15, Rb1, Rc5, Rd10), (Ra15, Rb1, Rc5, Rd11), (Ra15, Rb1, Rc5, Rd12), (Ra15, Rb1, Rc5, Rd13), (Ra15, Rb1, Rc5, Rd14), (Ra15, Rb1, Rc5, Rd15), (Ra15, Rb1, Rc5, Rd16), (Ra15, Rb1, Rc5, Rd17), (Ra15, Rb1, Rc5, Rd18), (Ra15, Rb1, Rc5, Rd19), (Ra15, Rb1, Rc5, Rd20), (Ra15, Rb1, Rc5, Rd21), (Ra15, Rb1, Rc5, Rd22), (Ra15, Rb1, Rc5, Rd23), (Ra15, Rb1, Rc5, Rd24), (Ra15, Rb1, Rc5, Rd25), (Ra15, Rb1, Rc5, Rd26), (Ra15, Rb1, Rc5, Rd27), (Ra15, Rb1, Rc5, Rd28), (Ra15, Rb1, Rc5, Rd29), (Ra15, Rb2, Rc1, Rd 1), (Ra15, Rb2, Rc1, Rd2), (Ra15, Rb2, Rc1, Rd3), (Ra15, Rb2, Rc1, Rd4), (Ra15, Rb2, Rc1, Rd5), (Ra15, Rb2, Rc1, Rd6), (Ra15, Rb2, Rc1, Rd7), (Ra15, Rb2, Rc1, Rd8), (Ra15, Rb2, Rc1, Rd9), (Ra15, Rb2, Rc1, Rd10), (Ra15, Rb2, Rc1, Rd11), (Ra15, Rb2, Rc1, Rd12), (Ra15, Rb2, Rc1, Rd13), (Ra15, Rb2, Rc1, Rd14), (Ra15, Rb2, Rc1, Rd15), (Ra15, Rb2, Rc1, Rd16), (Ra15, Rb2, Rc1, Rd17), (Ra15, Rb2, Rc1, Rd18), (Ra15, Rb2, Rc1, Rd19), (Ra15, Rb2, Rc1, Rd20), (Ra15, Rb2, Rc1, Rd21), (Ra15, Rb2, Rc1, Rd22), (Ra15, Rb2, Rc1, Rd23), (Ra15, Rb2, Rc1, Rd24), (Ra15, Rb2, Rc1, Rd25), (Ra15, Rb2, Rc1, Rd26), (Ra15, Rb2, Rc1, Rd27), (Ra15, Rb2, Rc1, Rd28), (Ra15, Rb2, Rc1, Rd29), (Ra15, Rb2, Rc2, Rd1), (Ra15, Rb2, Rc2, Rd2), (Ra15, Rb2, Rc2, Rd3), (Ra15, Rb2, Rc2, Rd4), (Ra15, Rb2, Rc2, Rd5), (Ra15, Rb2, Rc2, Rd6), (Ra15, Rb2, Rc2, Rd7), (Ra15, Rb2, Rc2, Rd8), (Ra 15, Rb2, Rc2, Rd9), (Ra15, Rb2, Rc2, Rd10), (Ra15, Rb2, Rc2, Rd11), (Ra15, Rb2, Rc2, Rd12), (Ra15, Rb2, Rc2, Rd13), ( Ra15, Rb2, Rc2, Rd14), (Ra15, Rb2, Rd2, (Rd16), (Ra15, Rb2, 17Rc2, Rd17), (Ra15, Rb2, Rc2, Rd18), ( Ra15, Rb2, Rc2, Rd19), (Ra15, Rb2, Rc2, Rd20), (Ra15, Rb2, Rc2, Rd21), (Ra15, Rb2, Rc2, Rd22), (Ra15, Rb2, Rc2, Rd23), ( Ra15, Rb2, Rc2, Rd24), (Ra15, Rb2, Rc2, (Rd26), (Ra15, Rb2, Rc2, Rd27), (Ra15, Rb2, Rc2, Rd28), ( (Ra15, Rb2, Rc2, Rd29), (Ra15, Rb2, Rc3, Rd1), (Ra15, Rb2, Rc3, Rd2), (Ra15, Rb2, Rc3, Rd3), (Ra15, Rb2, Rc3, Rd4), (Ra15, Rb2, Rc3, 5Rd5), (Ra15, Rb2, Rc3, Rd6), (Ra15, Rb2, Rc3, Rd7), (Ra15, Rb2, Rc3, Rd8), (Ra15, Rb2, Rc3, Rd9), (Ra15, Rb2, Rc3, 10Rd10), (Ra15, Rb2, Rc3, Rd11), (Ra15, Rb2, Rc3, Rd12), (Ra15, Rb2, Rc3, Rd13), (Ra15, Rb2, Rc3, Rd14), Ra15, Rb2, Rc3, Rd15), (Ra15 , Rb2, Rc3, Rd16), (Ra15, Rb2, Rc3, Rd17), (Ra15, Rb2, Rc3, Rd18), (Ra15, Rb2, Rc3, Rd19), (Ra15, Rb2, Rc3, Rd20), (Ra15 , Rb2, Rc3, Rd21), (Ra15, Rb2, Rc3, Rd22), (Ra15, Rb2, Rc3, Rd23), (Ra15, Rb2, Rc3, Rd24), (Ra15, Rb2, Rc3, Rd25), (Ra15 , Rb2, Rc3, Rd26), (Ra15, Rb2, Rc3, Rd27), (Ra15, Rb2, Rc3, Rd28), (Ra15, Rb2, Rc3, Rd29), (Ra15, Rb2, Rc4, Rd1), (Ra15 , Rb2, Rc4,4Rd2), (Ra15, Rb2, Rc4, Rd3), (Ra15, Rb2, Rc4, Rd4), (Ra15, Rb2, Rc4, Rd5),

(Ra15, Rb2, Rc4, Rd6), (Ra15, Rb2, Rc4, Rd7), (Ra15, Rb2, Rc4, Rd8), (Ra15, Rb2, Rc4, Rd9), (Ra15, Rb2, Rc4, Rd10), (Ra15, Rb2, Rc4, Rd11), (Ra15, Rb2, Rc4, Rd12), (Ra15, Rb2, Rc4, Rd13), (Ra15, Rb2, Rc4, Rd14), (Ra15, Rb2, Rc4, Rd15), (Ra15, Rb2, Rc4, Rd16), (Ra15, Rb2, Rc4, Rd17), (Ra15, Rb2, Rc4, Rd18), (Ra15, Rb2, Rc4, Rd19), (Ra15, Rb2, Rc4, Rd20), (Ra15, Rb2, Rc4, Rd21), (Ra15, Rb2, Rc4, Rd22), (Ra15, Rb2, Rc4, Rd23), (Ra15, Rb2, Rc4, Rd24), (Ra15, Rb2, Rc4, Rd25), (Ra15, Rb2, Rc4, Rd26), (Ra15, Rb2, Rc4, Rd27), (Ra15, Rb2, Rc4, Rd28), (Ra15, Rb2, Rc4, Rd29), (Ra15, Rb2, Rc5, Rd1), (Ra15, Rb2, Rc5, Rd2), (Ra15, Rb2, Rc5, Rd3), (Ra15, Rb2, Rc5, Rd4), (Ra15, Rb2, Rc5, Rd5), (Ra15, Rb2, Rc5, Rd6), (Ra15, Rb2, Rc5, Rd7), (Ra15, Rb2, Rc5, Rd8), (Ra15, Rb2, Rc5, Rd9), (Ra15, Rb2, Rc5, Rd10), (Ra15, Rb2, Rc5, Rd11), (Ra15, Rb2, Rc5, Rd12), (Ra 15, Rb2, Rc5, Rd13), (Ra15, Rb2, Rc5, Rd14), (Ra15, Rb2, Rc5, Rd15), (Ra15, Rb2, Rc5, Rd16), (Ra15, Rb2, Rc5, Rd17), (Ra15, Rb2, Rc5, 18Rd18), (Ra15, Rb2, Rc5, Rd19), (Ra15, Rb2, Rc5, Rd20), (Ra15, Rb2, Rc5, Rd21), (Ra15, Rb2, Rc5, Rd22), (Ra15, Rb2, Rc5, 23Rd23), (Ra15, Rb2, Rc5, Rd24), (Ra15, Rb2, Rc5, Rd25), (Ra15, Rb2, Rc5, Rd26), (Ra15, Rb2, Rc5, Rd27), (Ra15, bRb2, Rc5, Rd28), (Ra15, Rb2, Rc5, Rd29), (Ra16, Rb1, Rc1, Rd1), (Ra16, Rb1, Rc1, Rd2), (Ra16, Rb1, Rc1, Rd3), ( Ra16, Rb1, Rc1, Rd4), (Ra16, Rb1, Rc1, Rd5), (Ra16, Rb1, Rc1, Rd6), (Ra16, Rb1, Rc1, Rd7), (Ra16, Rb1, Rc1, Rd8), ( Ra16, Rb1, Rc1, 9Rd9), (Ra16, Rb1, Rc1, Rd10), (Ra16, Rb1, Rc1, Rd11), (Ra16, Rb1, Rc1, Rd12), (Ra16, Rb1, Rc1, Rd13), ( Ra16, Rb1, Rc1, Rd14), (Ra16, Rb1, Rc1, Rd15), (Ra16, Rb1, Rc1, Rd16), (Ra16, Rb1, Rc1, Rd17), (Ra16, Rb1, Rc1, Rd18), ( Ra16, Rb1, Rc1, Rd19), (Ra1 6, Rb1, cRc1, Rd20), (Ra16, Rb1, Rc1, Rd21), (Ra16, Rb1, Rc1, Rd22), (Ra16, Rb1, Rc1, Rd23), (Ra16, Rb1, Rc1, Rd24), ( Ra16, Rb1, Rc1, Rd25), (Ra16, Rb1, Rc1, Rd26), (Ra16, Rb1, Rc1, Rd27), (Ra16, Rb1, Rc1, Rd28), (Ra16, Rb1, Rc1, Rd29), ( Ra16, Rb1, Rc2, Rd1), (Ra16, Rb1, Rc2, Rd3), (Ra16, Rb1, Rc2, Rd4), (Ra16, Rb1, Rc2, Rd5), ( (Ra16, Rb1, cRc2, Rd6), (Ra16, Rb1, Rc2, Rd8), (Ra16, Rb1, Rc2, Rd9), (Ra16, Rb1, Rc2, Rd10), ( (Ra16, Rb1, Rc2, Rd11), (Ra16, Rb1, Rc2, Rd13), (Ra16, Rb1, Rc2, Rd14), (Ra16, Rb1, Rc2, Rd15), ( Ra16, Rb1, Rc2, dRd16), (Ra16, Rb1, Rc2, Rd17), (Ra16, Rb1, Rc2, Rd18), (Ra16, Rb1, Rc2, Rd19), (Ra16, Rb1, Rc2, Rd20), ( (Ra16, Rb1, Rc2, Rd21), (Ra16, Rb1, Rc2, Rd23), (Ra16, Rb1, Rc2, Rd24), (Ra16, Rb1, Rc2, Rd25), ( Ra16, Rb1, Rc2, Rd26), (Ra16 , Rb1, Rc2, Rd27), (Ra16, Rb1, Rc2, Rd28), (Ra16, Rb1, Rc2, Rd29), (Ra16, Rb1, Rc3, Rd1), (Ra16, Rb1, Rc3, Rd2), (Ra16 , Rb1, Rc3, Rd3), (Ra16, Rb1, Rc3, Rd4), (Ra16, Rb1, Rc3, Rd5), (Ra16, Rb1, Rc3, Rd6), (Ra16, Rb1, Rc3, Rd7), (Ra16 , Rb1, Rc3, Rd8), (Ra16, Rb1, Rc3, Rd9), (Ra16, Rb1, Rc3, Rd10), (Ra16, Rb1, Rc3, Rd11), (Ra16, Rb1, Rc3, Rd12), (Ra16 , Rb1, Rc3, Rd13), (Ra16, Rb1, Rc3, Rd14), (Ra16, Rb1, Rc3, Rd15), (Ra16, Rb1, Rc3, Rd16), (Ra16, Rb1, Rc3, Rd17), (Ra16 , Rb1, Rc3, Rd18), (Ra16, Rb1, Rc3, Rd19), (Ra16, Rb1, Rc3, Rd20), (Ra16, Rb1, Rc3, Rd21), (Ra16, Rb1, Rc3, Rd22), (Ra16 , Rb1, Rc3, Rd23), (Ra16, Rb1, Rc3, Rd24), (Ra16, Rb1, Rc3, Rd25), (Ra16, Rb1, Rc3, Rd26), (Ra16, Rb1, Rc3, Rd27), (Ra16 , Rb1, Rc3, Rd28), (Ra16, Rb1, Rc3, Rd29), (Ra16, Rb1, Rc4, Rd1), (Ra16, Rb1, Rc4, Rd2), (Ra16, Rb1, Rc4, Rd3), (Ra16 , Rb1, Rc4, Rd4), (Ra16, Rb 1, Rc4, Rd5), (Ra16, Rb1, Rc4, Rd6), (Ra16, Rb1, Rc4, Rd7), (Ra16, Rb1, Rc4, Rd8), (Ra16, Rb1, Rc4, Rd9), (Ra16, Rb1, Rc4, Rd10), (Ra16, Rb1, Rc4, Rd11), (Ra16, Rb1, Rc4, Rd12), (Ra16, Rb1, Rc4, Rd13), (Ra16, Rb1, Rc4, Rd14), (Ra16, Rb1, Rc4, Rd15), (Ra16, Rb1, Rc4, Rd16), (Ra16, Rb1, Rc4, Rd17), (Ra16, Rb1, Rc4, Rd18), (Ra16, Rb1, Rc4, Rd19), (Ra16, Rb1, Rc4, Rd20), (Ra16, Rb1, Rc4, Rd21), (Ra16, Rb1, Rc4, Rd22), (Ra16, Rb1, Rc4, Rd23), (Ra16, Rb1, Rc4, Rd24), (Ra16, Rb1, Rc4, Rd25), (Ra16, Rb1, Rc4, Rd26), (Ra16, Rb1, Rc4, Rd27), (Ra16, Rb1, Rc4, Rd28), (Ra16, Rb1, Rc4, Rd29), (Ra16, Rb1, Rc5, Rd1), (Ra16, Rb1, Rc5, Rd2), (Ra16, Rb1, Rc5, Rd3), (Ra16, Rb1, Rc5, Rd4), (Ra16, Rb1, Rc5, Rd5), (Ra16, Rb1, Rc5, Rd6), (Ra16, Rb1, Rc5, Rd7), (Ra16, Rb1, Rc5, Rd8), (Ra16, Rb1, Rc5, Rd9), (Ra16, Rb1, Rc5, Rd10), (Ra16, Rb1, Rc5, Rd11), (Ra16, Rb1, Rc 5, Rd12), (Ra16, Rb1, Rc5, Rd13), (Ra16, Rb1, Rc5, Rd14), (Ra16, Rb1, Rc5, Rd15), (Ra16, Rb1, Rc5, Rd16), (Ra16, Rb1, Rc5, Rd17), (Ra16, Rb1, Rc5, Rd18), (Ra16, Rb1, Rc5, Rd19), (Ra16, Rb1, Rc5, Rd20), (Ra16, Rb1, Rc5, Rd21), (Ra16, Rb1, Rc5, Rd22), (Ra16, Rb1, Rd5), (Ra16, Rb1, Rc5, Rd25), (Ra16, Rb1, Rc5, Rd26), (Ra16, Rb1, Rc5, Rd27), (Ra16, Rb1, Rc5, Rd28), (Ra16, Rb1, Rc5, Rd29), (Ra16, Rb2, Rc1, Rd1), (Ra16, Rb2, Rc1, Rd2), (Ra16, Rb2, Rc1, Rd3), (Ra16, Rb2, Rc1, Rd4), (Ra16, Rb2, Rc1, Rd5), (Ra16, Rb2, Rc1, Rd6), (Ra16, Rb2, Rc1, Rd7), (Ra16, Rb2, Rc1, Rd8), (Ra16, Rb2, Rc1, Rd9), (Ra16, Rb2, Rc1, Rd10), (Ra16, Rb2, Rc1, Rd11), (Ra16, Rb2, Rc1, Rd12), (Ra16, Rb2, Rc1, Rd13), (Ra16, Rb2, Rc1, Rd14), (Ra16, Rb2, Rc1, Rd15), (Ra16, Rb2, Rc1, Rd16), (Ra16, Rb2, Rc1, Rd17), (Ra16, Rb2, Rc1, Rd18), (Ra16, Rb2, Rc1 , Rd19), (Ra16, Rb2, Rc1, Rd20), (Ra16, Rb2, Rc1, Rd21), (Ra16, Rb2, Rc1, Rd22), (Ra16, Rb2, Rc1, Rd23), (Ra16, Rb2, Rc1 , Rd24), (Ra16, Rb2, Rc1, Rd26), (Ra16, Rb2, Rc1, Rd27), (Ra16, Rb2, Rc1, Rd28), (Ra16, Rb2, Rc1) , Rd29), (Ra16, Rb2, Rc2, Rd1), (Ra16, Rb2, Rc2, Rd2), (Ra16, Rb2, Rc2, Rd3), (Ra16, Rb2, Rc2, Rd4), (Ra16, Rb2, Rc2 , Rd5), (Ra16, Rb2, Rc2, Rd6), (Ra16, Rb2, Rc2, Rd7), (Ra16, Rb2, Rc2, Rd8), (Ra16, Rb2, Rc2, Rd9), (Ra16, Rb2, Rc2 , Rd10), (Ra16, Rb2, Rc2, Rd11), (Ra16, Rb2, Rc2, Rd12), (Ra16, Rb2, Rc2, Rd13), (Ra16, Rb2, Rc2, Rd14), (Ra16, Rb2, Rc2 , Rd15), (Ra16, Rb2, Rd2, RaRd16), (Ra16, Rb2, Rc2, Rd18), (Ra16, Rb2, Rc2, Rd19), (Ra16, Rb2, Rc2 , Rd20), (Ra16, Rb2, Rc2, Rd21), (Ra16, Rb2, Rc2, Rd22), (Ra16, Rb2, Rc2, Rd23), (Ra16, Rb2, Rc2, Rd24), (Ra16, Rb2, Rc2 , Rd25), (Ra16, Rb2, Rc2, Rd26), (Ra16, Rb2, Rc2, Rd27), (Ra16, Rb2, Rc2, Rd28), (Ra16, Rb2, Rc2, Rd29), (Ra16, Rb2, Rc3, Rd1), (Ra16, Rb2, Rc3, Rd2), (Ra16, Rb2, Rc3, Rd3), (Ra16, Rb2, Rc3, Rd4), (Ra16, Rb2, Rc3, Rd5), (Ra16, Rb2, Rc3, Rd6), (Ra16, Rb2, Rc3, Rd7), (Ra16, Rb2, Rc3, Rd8), (Ra16, Rb2, Rc3, Rd9), (Ra16, Rb2, Rc3, Rd10), (Ra16, Rb2, Rc3, Rd11), (Ra16, Rb2, Rc3, Rd12), (Ra16, Rb2, Rc3, Rd13), (Ra16, Rb2, Rc3, Rd14), (Ra16, Rb2, Rc3, Rd15), (Ra16, Rb2, Rc3, Rd16), (Ra16, Rb2, Rc3, Rd17), (Ra16, Rb2, Rc3, Rd18), (Ra16, Rb2, Rc3, Rd19), (Ra16, Rb2, Rc3, Rd20), (Ra16, Rb2, Rc3, Rd21), (Ra16, Rb2, Rc3, Rd22), (Ra16, Rb2, Rc3, Rd23), (Ra16, Rb2, Rc3, Rd24), (Ra16, Rb2, Rc3, Rd25), (Ra16, Rb2, Rc3, Rd26), (Ra16, Rb2, Rc3, Rd27), (Ra16, Rb2, Rc3, Rd28), (Ra16, Rb2, Rc3, Rd29), (Ra16, Rb2, Rc4, Rd1), (Ra16, Rb2, Rc4, Rd2), (Ra16, Rb2, Rc4, Rd3), (Ra16, Rb2, Rc4, Rd 4), (Ra16, Rb2, Rc4, Rd5), (Ra16, Rb2, Rc4, Rd6), (Ra16, Rb2, Rc4, Rd7), (Ra16, Rb2, Rc4, Rd8), (Ra16, Rb2, Rc4, Rd9), (Ra16, Rb2, Rc4, Rd10), (Ra16, Rb2, Rc4, Rd11), (Ra16, Rb2, Rc4, Rd12), (Ra16, Rb2, Rc4, Rd13), (Ra16, Rb2, Rc4, Rd14), (Ra16, Rb2, Rc4, Rd15), (Ra16, Rb2, Rc4, Rd16), (Ra16, Rb2, Rc4, Rd17), (Ra16, Rb2, Rc4, Rd18), (Ra16, Rb2, Rc4, Rd19), (Ra16, Rb2, Rc4, Rd20), (Ra16, Rb2, Rc4, Rd21), (Ra16, Rb2, Rc4, Rd22), (Ra16, Rb2, Rc4, Rd23), (Ra16, Rb2, Rc4, Rd24), (Ra16, Rb2, Rc4, Rd25), (Ra16, Rb2, Rc4, Rd26), (Ra16, Rb2, Rc4, Rd27), (Ra16, Rb2, Rc4, Rd28), (Ra16, Rb2, Rc4, Rd29), (Ra16, Rb2, Rc5, Rd1), (Ra16, Rb2, Rc5, Rd2), (Ra16, Rb2, Rc5, Rd3), (Ra16, Rb2, Rc5, Rd4), (Ra16, Rb2, Rc5, Rd5), (Ra16, Rb2, Rc5, Rd6), (Ra16, Rb2, Rc5, Rd7), (Ra16, Rb2, Rc5, Rd8), (Ra16, Rb2, Rc5, Rd9), (Ra16, Rb2, Rc5, Rd10), (Ra16, Rb2, Rc5, Rd11), ( (Ra16, Rb2, Rc5, Rd12), (Ra16, Rb2, Rc5, Rd13), (Ra16, Rb2, Rc5, Rd14), (Ra16, Rb2, Rc5, Rd15), (Ra16, Rb2, Rc5, Rd16), Ra16, Rb2, Rc5, 17Rd17), (Ra16, Rb2, Rc5, Rd18), (Ra16, Rb2, Rc5, Rd19), (Ra16, Rb2, Rc5, Rd20), (Ra16, Rb2, Rc5, Rd21), Ra16, Rb2, cRc5, Rd22), (Ra16, Rb2, Rc5, Rd23), (Ra16, Rb2, Rc5, Rd24), (Ra16, Rb2, Rc5, Rd25), (Ra16, Rb2, Rc5, Rd26), (Ra16, Rb2, Rc5,) Rd27), (Ra16, Rb2, Rc5, Rd28), (Ra16, Rb2, Rc5, Rd29), (Ra17, Rb1, Rc1, Rd1), (Ra17, Rb1, Rc1, Rd2), ( Ra17, Rb1, Rc1, 3Rd3), (Ra17, Rb1, Rc1, Rd4), (Ra17, Rb1, Rc1, Rd5), (Ra17, Rb1, Rc1, Rd6), (Ra17, Rb1, Rc1, Rd7), ( (Ra17, Rb1, cRc1, Rd8), (Ra17, Rb1, Rc1, Rd10), (Ra17, Rb1, 、 Rc1, Rd11), (Ra17, Rb1, Rc1, Rd12), ( Ra17, Rb1, Rc1, 13Rd13), (Ra17, Rb1, Rc1, Rd14), (Ra17, Rb1, Rc1, Rd15), (Ra17, Rb1, Rc1, Rd16), (Ra17, Rb1, Rc1, Rd17), ( Ra17, Rb1, Rc1, Rd18), (R a17, Rb1, Rc1, Rd19), (Ra17, Rb1, Rc1, Rd20), (Ra17, Rb1, Rc1, Rd21), (Ra17, Rb1, Rc1, Rd22), (Ra17, Rb1, Rc1, Rd23), ( Ra17, Rb1, Rc1, 24Rd24), (Ra17, Rb1, Rd1, RaRd26), (Ra17, Rb1, Rc1, Rd27), (Ra17, Rb1, Rc1, Rd28), ( Ra17, Rb1, Rc1, Rd29), (Ra17, Rb1, Rc2, Rd1), (Ra17, Rb1, Rc2, Rd2), (Ra17, Rb1, Rc2, Rd3), (Ra17, Rb1, Rc2, Rd4), ( Ra17, Rb1, Rc2, Rd5), (Ra17, Rb1, Rc2, Rd6), (Ra17, Rb1, Rc2, Rd7), (Ra17, Rb1, Rc2, Rd8),

(Ra17, Rb1, Rc2, Rd9), (Ra17, RaRb1, Rc2, Rd11), (Ra17, Rb1, Rc2, Rd12), (Ra17, Rb1, Rc2, Rd13), (Ra17, Rb1, Rc2, Rd14), (Ra17, Rb1, Rc2, Rd16), (Ra17, Rb1, Rc2, Rd17), (Ra17, Rb1, Rc2, Rd18), (Ra17, Rb1, Rc2, Rd19), (Ra17, Rb1, Rc2, Rd20), (Ra17, Rb1, Rc2, Rd21), (Ra17, Rb1, Rc2, Rd22), (Ra17, Rb1, Rc2, Rd23), (Ra17, Rb1, Rc2, Rd24), (Ra17, Rb1, Rc2, Rd25), (Ra17, Rb1, Rc2, Rd26), (Ra17, Rb1, Rc2, Rd27), (Ra17, Rb1, Rc2, Rd28), (Ra17, Rb1, Rc2, Rd29), (Ra17, Rb1, Rc3, Rd1), (Ra17, Rb1, Rc3, Rd2), (Ra17, Rb1, Rc3, Rd3), (Ra17, Rb1, Rc3, Rd4), (Ra17, Rb1, Rc3, Rd5), (Ra17, Rb1, Rc3, Rd6), (Ra17, Rb1, Rc3, Rd7), (Ra17, Rb1, Rc3, Rd8), (Ra17, Rb1, Rc3, Rd9), (Ra17, Rb1, Rc3, Rd10), (Ra17, Rb1, Rc3, Rd11), (Ra17, Rb1, Rc3, Rd12), (Ra17, Rb1, Rc3, Rd13), (Ra17, Rb1, Rc3, Rd14), (Ra17, Rb1, Rc3, Rd15), (Ra17, Rb1, Rc3, Rd16), (Ra17, Rb1, Rc3, Rd17), (Ra17, Rb1, Rc3, Rd18), (Ra17, Rb1, Rc3, Rd19), (Ra17, Rb1, Rc3, Rd20), (Ra17, Rb1, Rc3, Rd21), (Ra17, Rb1, Rc3, Rd22), (Ra17, Rb1, Rc3, Rd23), (Ra17, Rb1, Rc3, Rd24), (Ra17, Rb1, Rc3, Rd25), (Ra17, Rb1, Rc3, Rd26), (Ra17, Rb1, Rc3, Rd27), (Ra17, Rb1, Rc3, Rd28), (Ra17, Rb1, Rc3, Rd29), (Ra17, Rb1, Rc4, Rd1), (Ra17, Rb1, Rc4, Rd2), (Ra17, Rb1, Rc4, Rd3), (Ra17, Rb1, Rc4, Rd4), (Ra17, Rb1, Rc4, Rd5), (Ra17, Rb1, Rc4, Rd6), (Ra17, Rb1, Rc4, Rd7), (Ra17, Rb1, Rc4, Rd8), (Ra17, Rb1, Rc4, Rd9), (Ra17, Rb1, Rc4, Rd10), (Ra17, Rb1, Rc4, Rd11), (Ra17, Rb1, Rc4, Rd12), (Ra17, Rb1, Rc4, Rd13), (Ra17, Rb1, Rc4, Rd14), (Ra17, Rb1, Rc4, Rd15), (Ra17, Rb1, Rc4, Rd16), (Ra17, Rb1, Rc4, Rd17), (Ra17, Rb1, Rc4, Rd18), (Ra17, Rb1, Rc4, Rd19), (Ra17, Rb1, Rc4, Rd20), (Ra17, Rb1, Rc4, Rd21), (Ra17, Rb1, Rc4, Rd22), ( (Ra17, Rb1, cRc4, Rd23), (Ra17, Rb1, Rc4, Rd24), (Ra17, Rb1, Rc4, Rd25), (Ra17, Rb1, Rc4, Rd26), (Ra17, Rb1, Rc4, Rd27), Ra17, Rb1, Rc4, Rd28), (Ra17, Rb1, Rc4, Rd29), (Ra17, Rb1, Rc5, Rd1), (Ra17, Rb1, Rc5, Rd2), (Ra17, Rb1, Rc5, Rd3), (Ra17, Rb1, Rc5, Rd4), (Ra17, Rb1, Rc5, Rd5), (Ra17, Rb1, Rc5, Rd6), (Ra17, Rb1, Rc5, Rd7), (Ra17, Rb1, Rc5, Rd8), Ra17, Rb1, Rc5, Rd9), (Ra17, Rb1, Rc5, Rd10), (Ra17, Rb1, Rc5, Rd11), (Ra17, Rb1, Rc5, Rd12), (Ra17, Rb1, Rc5, Rd13), (Ra17, Rb1, Rc5, Rd14), (Ra17, Rb1, Rc5, Rd15), (Ra17, Rb1, Rc5, Rd16), (Ra17, Rb1, Rc5, Rd17), (Ra17, Rb1, Rc5, Rd18), (Ra17, Rb1, Rc5, 19Rd19), (Ra17, Rb1, Rc5, Rd20), (Ra17, Rb1, Rc5, Rd21), (Ra17, Rb1, Rc5, Rd22), (Ra17, Rb1, Rc5, Rd23), (Ra17, Rb1, cRc5, Rd24), (Ra17, Rb1, Rc5, (Rd26), (Ra17, Rb1, Rc5, Rd27), (Ra17, Rb1, Rc5, Rd28), Ra17, Rb1, Rc5, Rd29), (R a17, Rb2, Rc1, 1Rd1), (Ra17, Rb2, Rc1, Rd2), (Ra17, Rb2, Rc1, Rd3), (Ra17, Rb2, Rc1, Rd4), (Ra17, Rb2, Rc1, Rd5), ( Ra17, Rb2, Rc1, Rd6), (Ra17, Rb2, Rc1, Rd7), (Ra17, Rb2, Rc1, Rd8), (Ra17, Rb2, Rc1, Rd9), (Ra17, Rb2, Rc1, Rd10), ( Ra17, Rb2, Rc1, Rd11), (Ra17, Rb2, Rc1, 、 Rd12), (Ra17, Rb2, Rc1, Rd13), (Ra17, Rb2, Rc1, Rd14), (Ra17, Rb2, Rc1, Rd15), ( Ra17, Rb2, Rc1, Rd16), (Ra17, Rb2, Rc1, Rd17), (Ra17, Rb2, Rc1, Rd18), (Ra17, Rb2, Rc1, Rd19), (Ra17, Rb2, Rc1, Rd20), ( Ra17, Rb2, Rc1, Rd21), (Ra17, Rb2, Rd1, Rd23), (Ra17, Rb2, Rc1, 17Rd24), (Ra17, Rb2, Rc1, Rd25), ( Ra17, Rb2, Rc1, Rd26), (Ra17, Rb2, Rc1, Rd27), (Ra17, Rb2, Rc1, Rd28), (Ra17, Rb2, Rc1, Rd29), (Ra17, Rb2, Rc2, Rd1), ( Ra17, Rb2, Rc2, Rd2), (Ra17, Rb2, Rd2, RaRd4), (Ra17, Rb2, Rc2, Rd5), (Ra17, Rb2, Rc2, Rd6), ( Ra17, Rb2, Rc2, Rd7), (Ra17, Rb 2, Rc2, Rd8), (Ra17, Rb2, Rc2, Rd9), (Ra17, Rb2, Rc2, Rd10), (Ra17, Rb2, Rc2, Rd11), (Ra17, Rb2, Rc2, Rd12), (Ra17, Rb2, Rc2, Rd13), (Ra17, Rb2, Rc2, Rd14), (Ra17, Rb2, Rc2, Rd15), (Ra17, Rb2, Rc2, Rd16), (Ra17, Rb2, Rc2, Rd17), (Ra17, Rb2, Rc2, Rd18), (Ra17, Rb2, Rc2, Rd19), (Ra17, Rb2, Rc2, Rd20), (Ra17, Rb2, Rc2, Rd21), (Ra17, Rb2, Rc2, Rd22), (Ra17, Rb2, Rc2, Rd23), (Ra17, Rb2, Rc2, Rd24), (Ra17, Rb2, Rc2, Rd25), (Ra17, Rb2, Rc2, Rd26), (Ra17, Rb2, Rc2, Rd27), (Ra17, Rb2, Rc2, Rd28), (Ra17, Rb2, Rc2, Rd29), (Ra17, Rb2, Rc3, Rd1), (Ra17, Rb2, Rc3, Rd2), (Ra17, Rb2, Rc3, Rd3), (Ra17, Rb2, Rc3, Rd4), (Ra17, Rb2, Rc3, Rd5), (Ra17, Rb2, Rc3, Rd6), (Ra17, Rb2, Rc3, Rd7), (Ra17, Rb2, Rc3, Rd8), (Ra17, Rb2, Rc3, Rd9), (Ra17, Rb2, Rc3, Rd10), (Ra17, Rb2, Rc3, Rd11), (Ra17, Rb2, Rc3, Rd12), (Ra17, Rb2, Rc3, Rd13), (Ra17, Rb2, Rc3, Rd14), (Ra17, Rb2, Rc3, Rd15), (Ra17, Rb2, Rc3, Rd16), (Ra17, Rb2, Rc3, Rd17), (Ra17, Rb2, Rc3, Rd18), (Ra17, Rb2, Rc3, Rd19), (Ra17, Rb2, Rc3, Rd20), (Ra17, Rb2, Rc3, Rd21), (Ra17, Rb2, Rc3, Rd22), (Ra17, Rb2, Rc3, Rd23), (Ra17, Rb2, Rc3, Rd24), (Ra17, Rb2, Rc3, Rd25), (Ra17, Rb2, Rc3, Rd26), (Ra17, Rb2, Rc3, Rd27), (Ra17, Rb2, Rc3, Rd28), (Ra17, Rb2, Rc3, Rd29), (Ra17, Rb2, Rc4, Rd1), (Ra17, Rb2, Rc4, Rd2), (Ra17, Rb2, Rc4, Rd3), (Ra17, Rb2, Rc4, Rd4), (Ra17, Rb2, Rc4, Rd5), (Ra17, Rb2, Rc4, Rd6), (Ra17, Rb2, Rc4, Rd7), (Ra17, Rb2, Rc4, Rd8), (Ra17, Rb2, Rc4, Rd9), (Ra17, Rb2, Rc4, Rd10), (Ra17, Rb2, Rc4, Rd11), (Ra17, Rb2, Rc4, Rd12), (Ra17, Rb2, Rc4, Rd13), (Ra17, Rb2, Rc4, Rd14), (Ra17, Rb2, Rc4, Rd15), (Ra17, Rb2, Rc4, Rd16), (Ra17, Rb2, Rc4, Rd17), (Ra17, Rb2, Rc4, Rd18), (Ra17, Rb2, Rc4, Rd19), (Ra17, Rb2, Rc4, Rd20), (Ra17, Rb2, Rc4, Rd21), (Ra17, Rb2, Rc4, Rd22), (Ra17, Rb2, Rc4, Rd23), (Ra17, Rb2, Rc4, Rd24), (Ra17, Rb2, Rc4, Rd25), (Ra17, Rb2, Rc4, Rd26), (Ra17, Rb2, Rc4, Rd27), (Ra17, Rb2, Rc4, Rd28), (Ra17, Rb2, Rc4, Rd29), (Ra17, Rb2, Rc5, Rd1), (Ra17, Rb2, Rc5, Rd2), (Ra17, Rb2, Rc5, Rd3), (Ra17, Rb2, Rc5, Rd4), (Ra17, Rb2, Rc5, Rd5), (Ra17, Rb2, Rc5, Rd6), (Ra17, Rb2, Rc5, Rd7), (Ra17, Rb2, Rc5, Rd8), (Ra17, Rb2, Rc5, Rd9), (Ra17, Rb2, Rc5, Rd10), (Ra17, Rb2, Rc5, Rd11), (Ra17, Rb2, Rc5, Rd12), (Ra17, Rb2, Rc5, Rd13), (Ra17, Rb2, Rc5, Rd14), (Ra17, Rb2, Rc5, Rd15), (Ra17, Rb2, Rc5, Rd16), (Ra17, Rb2, Rc5, Rd17), (Ra17, Rb2, Rc5, Rd18), (Ra17, Rb2, Rc5, Rd19), (Ra17, Rb2, Rc5, Rd20), (Ra17, Rb2, Rc5, Rd21), (Ra17, Rb2, Rc5, Rd22), (Ra17, Rb2, Rc5, Rd23), (Ra17, Rb2, Rc5, Rd24), (Ra17, Rb2, Rc5, Rd25), (Ra17, Rb2, Rc5, Rd26), (Ra17, Rb2, Rc5, Rd27), (Ra17, Rb2, Rc5, Rd28), (Ra17, Rb2, R c5, Rd29), (Ra18, Rb1, Rc1, Rd1), (Ra18, Rb1, Rc1, Rd3), (Ra18, Rb1, Rc1, Rd4), (Ra18, Rb1, Rc1, Rd5), (Ra18, Rb1, Rc1, Rd6), (Ra18, Rb1, Rc1, Rd7), (Ra18, Rb1, Rc1, Rd8), (Ra18, Rb1, Rc1, Rd9), (Ra18, Rb1, Rc1, Rd10), (Ra18, Rb1, Rc1, Rd11), (Ra18, Rb1, Rc1, Rd12), (Ra18, Rb1, Rc1, Rd13), (Ra18, Rb1, Rc1, Rd14), (Ra18, Rb1, Rc1, Rd15), (Ra18, Rb1, Rc1, Rd16), (Ra18, Rb1, Rc1, Rd17), (Ra18, Rb1, Rc1, Rd18), (Ra18, Rb1, Rc1, Rd19), (Ra18, Rb1, Rc1, Rd20), (Ra18, Rb1, Rc1, Rd21), (Ra18, Rb1, Rc1, Rd22), (Ra18, Rb1, Rc1, Rd23), (Ra18, Rb1, Rc1, Rd24), (Ra18, Rb1, Rc1, Rd25), (Ra18, Rb1, Rc1, Rd26), (Ra18, Rb1, Rc1, Rd27), (Ra18, Rb1, Rc1, Rd28), (Ra18, Rb1, Rc1, Rd29), (Ra18, Rb1, Rc2, Rd1), (Ra18, Rb1, Rc2, Rd2), (Ra18, Rb1, Rc2, Rd3), (Ra18, Rb1, Rc2, Rd4), (Ra18, Rb1, Rc2, Rd5), (Ra18, Rb1, Rc2, Rd6), (Ra18, Rb1, Rc2, Rd 7), (Ra18, Rb1, Rc2, Rd8), (Ra18, Rb1, Rc2, Rd9), (Ra18, Rb1, Rc2, Rd10), (Ra18, Rb1, Rc2, Rd11), (Ra18, Rb1, Rc2, Rd12), (Ra18, Rb1, Rc2, Rd13), (Ra18, Rb1, Rc2, Rd14), (Ra18, Rb1, Rc2, Rd15), (Ra18, Rb1, Rc2, Rd16), (Ra18, Rb1, Rc2, Rd17), (Ra18, Rb1, Rc2, Rd18), (Ra18, Rb1, Rc2, Rd19), (Ra18, Rb1, Rc2, Rd20), (Ra18, Rb1, Rc2, Rd21), (Ra18, Rb1, Rc2, Rd22), (Ra18, Rb1, Rc2, Rd23), (Ra18, Rb1, Rc2, Rd24), (Ra18, Rb1, Rc2, Rd25), (Ra18, Rb1, Rc2, Rd26), (Ra18, Rb1, Rc2, Rd27), (Ra18, Rb1, Rc2, Rd28), (Ra18, Rb1, Rc2, Rd29), (Ra18, Rb1, Rc3, Rd1), (Ra18, Rb1, Rc3, Rd2), (Ra18, Rb1, Rc3, Rd3), (Ra18, Rb1, Rc3, Rd4), (Ra18, Rb1, Rc3, Rd5), (Ra18, Rb1, Rc3, Rd6), (Ra18, Rb1, Rc3, Rd7), (Ra18, Rb1, Rc3, Rd8), (Ra18, Rb1, Rc3, Rd9), (Ra18, Rb1, Rc3, Rd10), (Ra18, Rb1, Rc3, Rd11), (Ra18, Rb1, Rc3, Rd12), (Ra18, Rb1, Rc3, Rd13), (Ra18, Rb1, Rc3, Rd14) (Ra18, Rb1, Rc3, Rd15), (Ra18, Rb1, Rc3, Rd17), (Ra18, Rb1, Rc3, Rd18), (Ra18, Rb1, Rc3, Rd19), (Ra18, Rb1, Rc3, Rd20), (Ra18, Rb1, Rc3, Rd21), (Ra18, Rb1, Rc3, Rd22), (Ra18, Rb1, Rc3, Rd23), (Ra18, Rb1, Rc3, Rd24), (Ra18, Rb1, Rc3, Rd25), (Ra18, Rb1, Rc3, Rd26), (Ra18, Rb1, Rc3, Rd27), (Ra18, Rb1, Rc3, Rd28), (Ra18, Rb1, Rc3, Rd29), (Ra18, Rb1, Rc4, Rd1), (Ra18, Rb1, Rc4, Rd2), (Ra18, Rb1, Rc4, Rd3), (Ra18, Rb1, Rc4, Rd4), (Ra18, Rb1, Rc4, Rd5), (Ra18, Rb1, Rc4, Rd6), (Ra18, Rb1, Rc4, Rd7), (Ra18, Rb1, Rc4, Rd8), (Ra18, Rb1, Rc4, Rd9), (Ra18, Rb1, Rc4, Rd10), (Ra18, Rb1, Rc4, Rd11), (Ra18, Rb1, Rc4, Rd12), (Ra18, Rb1, Rc4, Rd13), (Ra18, Rb1, Rc4, Rd14), (Ra18, Rb1, Rc4, Rd15), (Ra18, Rb1, Rc4, Rd16), (Ra18, Rb1, Rc4, Rd17), (Ra18, Rb1, Rc4, Rd18), (Ra18, Rb1, Rc4, Rd19), (Ra18, Rb1, Rc4, Rd20), (Ra18, Rb1, Rc4, Rd21) (Ra18, Rb1, Rc4, Rd22), (Ra18, Rb1, Rc4, Rd23), (Ra18, Rb1, Rc4, Rd24), (Ra18, Rb1, Rc4, Rd25), (Ra18, Rb1, Rc4, Rd26), (Ra18, Rb1, Rc4, Rd27), (Ra18, Rb1, Rc4, Rd28), (Ra18, Rb1, Rc4, Rd29), (Ra18, Rb1, Rc5, Rd1), (Ra18, Rb1, Rc5, Rd2), (Ra18, Rb1, Rc5, Rd3), (Ra18, Rb1, Rc5, Rd4), (Ra18, Rb1, Rc5, Rd5), (Ra18, Rb1, Rc5, Rd6), (Ra18, Rb1, Rc5, Rd7), (Ra18, Rb1, Rc5, Rd8), (Ra18, Rb1, Rc5, Rd9), (Ra18, Rb1, Rc5, Rd10), (Ra18, Rb1, Rc5, Rd11), (Ra18, Rb1, Rc5, Rd12), (Ra18, Rb1, Rc5, Rd13), (Ra18, Rb1, Rc5, Rd15), (Ra18, Rb1,18Rc5, bRd16), (Ra18, Rb1, Rc5, Rd17), (Ra18, Rb1, Rc5, Rd18),

(Ra18, Rb1, Rc5, Rd19), (Ra18, Rb1, Rc5, Rd20), (Ra18, Rb1, Rc5, Rd21), (Ra18, Rb1, Rc5, Rd22), (Ra18, Rb1, Rc5, Rd23), (Ra18, Rb1, Rc5, Rd24), (Ra18, Rb1, Rc5, Rd25), (Ra18, Rb1, Rc5, Rd26), (Ra18, Rb1, Rc5, Rd27), (Ra18, Rb1, Rc5, Rd28), (Ra18, Rb1, Rc5, Rd29), (Ra18, Rb2, Rc1, Rd1), (Ra18, Rb2, Rc1, Rd2), (Ra18, Rb2, Rc1, Rd3), (Ra18, Rb2, Rc1, Rd4), (Ra18, Rb2, Rc1, Rd5), (Ra18, Rb2, Rc1, Rd6), (Ra18, Rb2, Rc1, Rd7), (Ra18, Rb2, Rc1, Rd8), (Ra18, Rb2, Rc1, Rd9), (Ra18, Rb2, Rc1, Rd10), (Ra18, Rb2, Rc1, Rd12), (Ra18, Rb2,18Rc1, Rd13), (Ra18, Rb2, Rc1, Rd14), (Ra18, Rb2, Rc1, Rd15), (Ra18, Rb2, Rc1, Rd17), (Ra18, Rb2, Rc1, Rd18), (Ra18, Rb2, Rc1, Rd19), (Ra18, Rb2, Rc1, Rd20), (Ra18, Rb2, Rc1, Rd21), (Ra18, Rb2, Rc1, Rd22), (Ra18, Rb2, Rc1, Rd23), (Ra18, Rb2, Rc1, Rd24), (Ra18, Rb2, Rc1, Rd25) (Ra18, Rb2, Rc1, Rd26), (Ra18, Rb2, Rc1, Rd28), (Ra18, Rb2, Rc1, Rd29), (Ra18, Rb2, Rc2, Rd1), (Ra18, Rb2, Rc2, Rd2), (Ra18, Rb2, Rc2, Rd3), (Ra18, Rb2, Rc2, Rd4), (Ra18, Rb2, Rc2, Rd5), (Ra18, Rb2, Rc2, Rd6), (Ra18, Rb2, Rc2, Rd7), (Ra18, Rb2, Rc2, Rd8), (Ra18, Rb2, Rc2, Rd9), (Ra18, Rb2, Rc2, Rd10), (Ra18, Rb2, Rc2, Rd11), (Ra18, Rb2, Rc2, Rd12), (Ra18, Rb2, Rc2, Rd14), (Ra18, Rb2, Rc2, Rd15), (Ra18, Rb2, Rc2, Rd16), (Ra18, Rb2, Rc2, Rd17), (Ra18, Rb2, Rc2, Rd19), (Ra18, Rb2, Rc2, Rd20), (Ra18, Rb2, Rc2, Rd21), (Ra18, Rb2, Rc2, Rd22), (Ra18, Rb2, Rc2, Rd24), (Ra18, Rb2, Rc2, Rd25), (Ra18, Rb2, Rc2, Rd26), (Ra18, Rb2, Rc2, Rd27), (Ra18, RaRb2, Rc2, Rd29), (Ra18, Rb2, Rc3, Rd1), (Ra18, Rb2, Rc3, Rd2), (Ra18, Rb2, Rc3, Rd3), (Ra 18, Rb2, Rc3, Rd4), (Ra18, Rb2, Rc3, Rd5), (Ra18, Rb2, Rc3, Rd6), (Ra18, Rb2, Rc3, Rd7), (Ra18, Rb2, Rc3, Rd8), (Ra18, Rb2, Rc3, Rd9), (Ra18, Rb2, Rc3, Rd10), (Ra18, Rb2, Rc3, Rd11), (Ra18, Rb2, Rc3, Rd12), (Ra18, Rb2, Rc3, Rd13), Ra18, Rb2, Rc3, Rd14), (Ra18, Rb2, Rc3, Rd15), (Ra18, Rb2, Rc3, Rd16), (Ra18, Rb2, Rc3, Rd17), (Ra18, Rb2, Rc3, Rd18), (Ra18, Rb2, Rc3, Rd19), (Ra18, Rb2, Rc3, Rd20), (Ra18, Rb2, Rc3, Rd21), (Ra18, Rb2, Rc3, Rd22), (Ra18, Rb2, Rc3, Rd23), (Ra18, Rb2, Rc3, Rd24), (Ra18, Rb2, Rc3, Rd25), (Ra18, Rb2, Rc3, Rd26), (Ra18, Rb2, Rc3, Rd27), (Ra18, Rb2, Rc3, Rd28), (Ra18, Rb2, Rc3, Rd29), (Ra18, Rb2, Rc4, Rd1), (Ra18, Rb2, Rc4, Rd2), (Ra18, Rb2, Rc4, Rd3), (Ra18, Rb2, Rc4, Rd4), (Ra18, Rb2, Rc4, Rd5), (Ra18, Rb2, Rc4, Rd6), (Ra18, Rb2, Rc4, Rd7), (Ra18, Rb2, Rc4, Rd8), (Ra18, Rb2, Rc4, Rd9), Ra18, Rb2, Rc4, Rd10), (Ra18, Rb 2, Rc4, Rd11), (Ra18, Rb2, Rc4, Rd12), (Ra18, Rb2, Rc4, Rd13), (Ra18, Rb2, Rc4, Rd14), (Ra18, Rb2, Rc4, Rd15), (Ra18, Rb2, Rc4, Rd16), (Ra18, Rb2, Rc4, Rd17), (Ra18, Rb2, Rc4, Rd18), (Ra18, Rb2, Rc4, Rd19), (Ra18, Rb2, Rc4, Rd20), (Ra18, Rb2, Rc4, Rd21), (Ra18, Rb2, Rc4, Rd22), (Ra18, Rb2, Rc4, Rd23), (Ra18, Rb2, Rc4, Rd24), (Ra18, Rb2, Rc4, Rd25), (Ra18, Rb2, Rc4, Rd26), (Ra18, Rb2, Rc4, Rd27), (Ra18, Rb2, Rc4, Rd28), (Ra18, Rb2, Rc4, Rd29), (Ra18, Rb2, Rc5, Rd1), (Ra18, Rb2, Rc5, Rd2), (Ra18, Rb2, Rc5, Rd3), (Ra18, Rb2, Rc5, Rd4), (Ra18, Rb2, Rc5, Rd5), (Ra18, Rb2, Rc5, Rd6), (Ra18, Rb2, Rc5, Rd7), (Ra18, Rb2, Rc5, Rd8), (Ra18, Rb2, Rc5, Rd9), (Ra18, Rb2, Rc5, Rd10), (Ra18, Rb2, Rc5, Rd11), (Ra18, Rb2, Rc5, Rd12), (Ra18, Rb2, Rc5, Rd13), (Ra18, Rb2, Rc5, Rd14), (Ra18, Rb2, Rc5, Rd15), (Ra18, Rb2, Rc5, Rd16), (Ra18, Rb2, Rc5, Rd17), (Ra18, Rb2 , Rc5, Rd18), (Ra18, Rb2, Rc5, Rd19), (Ra18, Rb2, Rc5, Rd20), (Ra18, Rb2, Rc5, Rd21), (Ra18, Rb2, Rc5, Rd22), (Ra18, Rb2) , Rc5, Rd23), (Ra18, Rb2, Rc5, Rd24), (Ra18, Rb2, Rc5, Rd25), (Ra18, Rb2, Rc5, Rd26), (Ra18, Rb2, Rc5, Rd27), (Ra18, Rb2) , Rc5, Rd28), (Ra18, Rb2, Rc5, 、 Rd29), (Ra19, Rb1, Rc1, Rd1), (Ra19, Rb1, Rc1, Rd2), (Ra19, Rb1, Rc1, Rd3), (Ra19, Rb1 , Rc1, Rd4), (Ra19, Rb1, Rc1, Rd5), (Ra19, Rb1, Rc1, Rd6), (Ra19, Rb1, Rc1, Rd7), (Ra19, Rb1, Rc1, Rd8), (Ra19, Rb1 , Rc1, Rd9), (Ra19, Rb1, Rc1, Rd10), (Ra19, Rb1, Rc1, Rd11), (Ra19, Rb1, Rc1, Rd12), (Ra19, Rb1, Rc1, Rd13), (Ra19, Rb1 , Rc1, Rd14), (Ra19, Rb1, Rc1, Rd15), (Ra19, Rb1, Rc1, Rd16), (Ra19, Rb1, Rc1, Rd17), (Ra19, Rb1, Rc1, Rd18), (Ra19, Rb1 , Rc1, Rd19), (Ra19, Rb1, Rc1, Rd20), (Ra19, Rb1, Rc1, Rd21), (Ra19, Rb1, Rc1, Rd22), (Ra19, Rb1, Rc1, Rd23), (Ra19, Rb1 , Rc1, Rd24), (Ra19, Rb1, Rc1, Rd25), (Ra19, Rb1, Rc1, Rd26), (Ra19, Rb1, Rc1, Rd27), (Ra19, Rb1, Rc1, Rd28), (Ra19, Rb1, Rc1, Rd29), (Ra19, Rb1, Rc2, Rd1), (Ra19, Rb1, Rc2, Rd2), (Ra19, Rb1, Rc2, Rd3), (Ra19, Rb1, Rc2, Rd4), (Ra19, Rb1, Rc2, Rd5), (Ra19, Rb1, Rc2, Rd6), (Ra19, Rb1, Rc2, Rd7), (Ra19, Rb1, Rc2, Rd8), (Ra19, Rb1, Rc2, Rd9), (Ra19, Rb1, Rc2, Rd10), (Ra19, Rb1, Rc2, Rd11), (Ra19, Rb1, Rc2, Rd12), (Ra19, Rb1, Rc2, Rd13), (Ra19, Rb1, Rc2, Rd14), (Ra19, Rb1, Rc2, Rd15), (Ra19, Rb1, Rc2, Rd16), (Ra19, Rb1, Rc2, Rd17), (Ra19, Rb1, Rc2, Rd18), (Ra19, Rb1, Rc2, Rd19), (Ra19, Rb1, Rc2, Rd20), (Ra19, Rb1, Rc2, Rd21), (Ra19, Rb1, Rc2, Rd22), (Ra19, Rb1, Rc2, Rd23), (Ra19, Rb1, Rc2, Rd24), (Ra19, Rb1, Rc2, Rd25), (Ra19, Rb1, Rc2, Rd26), (Ra19, Rb1, Rc2, Rd27), (Ra19, Rb1, Rc2, Rd28), (Ra19, Rb1, Rc2, Rd29), (Ra19, Rb1, Rc3, Rd1), (Ra19, Rb1, Rc3, Rd2), (Ra19, Rb1, R c3, Rd3), (Ra19, Rb1, Rc3, Rd4), (Ra19, Rb1, Rc3, Rd6), (Ra19, Rb1, Rc3, Rd7), (Ra19, Rb1, Rc3, Rd8), (Ra19, Rb1, Rc3, Rd9), (Ra19, Rb1, Rc3, Rd10), (Ra19, Rb1, Rc3, Rd11), (Ra19, Rb1, Rc3, Rd12), (Ra19, Rb1, Rc3, Rd13), (Ra19, Rb1, Rc3, Rd14), (Ra19, Rb1, Rc3, Rd15), (Ra19, Rb1, Rc3, Rd16), (Ra19, Rb1, Rc3, Rd17), (Ra19, Rb1, Rc3, Rd18), (Ra19, Rb1, Rd3), (Ra19, Rb1, Rc3, Rd20), (Ra19, Rb1, Rc3, Rd21), (Ra19, Rb1, Rc3, Rd22), (Ra19, Rb1, Rc3, Rd23), (Ra19, Rb1, Rc3, Rd24), (Ra19, Rb1, Rc3, Rd25), (Ra19, Rb1, Rc3, Rd26), (Ra19, Rb1, Rc3, Rd27), (Ra19, Rb1, Rc3, Rd28), (Ra19, Rb1, Rc3, Rd29), (Ra19, Rb1, Rc4, Rd1), (Ra19, Rb1, Rc4, Rd2), (Ra19, Rb1, Rc4, Rd3), (Ra19, Rb1, Rc4, Rd4), (Ra19, Rb1, Rc4, Rd5), (Ra19, Rb1, Rc4, Rd6), (Ra19, Rb1, Rc4, Rd7), (Ra19, Rb1, Rc4, Rd8), (Ra19, Rb1, Rc4, Rd9), (Ra19, Rb1, Rc4, Rd1 0), (Ra19, Rb1, Rc4, Rd11), (Ra19, Rb1, Rc4, Rd12), (Ra19, Rb1, Rc4, Rd13), (Ra19, Rb1, Rc4, Rd14), (Ra19, Rb1, Rc4, Rd15), (Ra19, Rb1, Rc4, Rd16), (Ra19, Rb1, Rc4, Rd17), (Ra19, Rb1, Rc4, Rd18), (Ra19, Rb1, Rc4, Rd19), (Ra19, Rb1, Rc4, Rd20), (Ra19, Rb1, Rc4, Rd21), (Ra19, Rb1, Rc4, Rd22), (Ra19, Rb1, Rc4, Rd23), (Ra19, Rb1, Rc4, Rd24), (Ra19, Rb1, Rc4, Rd25), (Ra19, Rb1, Rc4, Rd26), (Ra19, Rb1, Rc4, Rd27), (Ra19, Rb1, Rc4, Rd28), (Ra19, Rb1, Rc4, Rd29), (Ra19, Rb1, Rc5, Rd1), (Ra19, Rb1, Rc5, Rd2), (Ra19, Rb1, Rc5, Rd3), (Ra19, Rb1, Rc5, Rd4), (Ra19, Rb1, Rc5, Rd5), (Ra19, Rb1, Rc5, Rd6), (Ra19, Rb1, Rc5, Rd7), (Ra19, Rb1, Rc5, Rd8), (Ra19, Rb1, Rc5, Rd9), (Ra19, Rb1, Rc5, Rd10), (Ra19, Rb1, Rc5, Rd11), (Ra19, Rb1, Rc5, Rd12), (Ra19, Rb1, Rc5, Rd13), (Ra19, Rb1, Rc5, Rd14), (Ra19, Rb1, Rc5, Rd15), (Ra19, Rb1, Rc5, Rd16), (Ra19, Rb1, Rc5, Rd17 ), (Ra19, Rb1, Rc5, Rd18), (Ra19, Rb1, Rc5, Rd19), (Ra19, Rb1, Rc5, Rd20), (Ra19, Rb1, Rc5, Rd21), (Ra19, Rb1, Rc5, Rd22) ), (Ra19, Rb1, Rc5, Rd23), (Ra19, Rb1, Rc5, Rd24), (Ra19, Rb1, Rc5, Rd25), (Ra19, Rb1, Rc5, Rd26), (Ra19, Rb1, Rc5, Rd27) ), (Ra19, Rb1, Rc5, Rd28), (Ra19, Rb1, Rc5, Rd29), (Ra19, Rb2, Rc1, Rd1), (Ra19, Rb2, Rc1, Rd2), (Ra19, Rb2, Rc1, Rd3) ), (Ra19, Rb2, Rc1, Rd4), (Ra19, Rb2, Rc1, Rd5), (Ra19, Rb2, Rc1, Rd6), (Ra19, Rb2, Rc1, Rd7), (Ra19, Rb2, Rc1, Rd8) ), (Ra19, Rb2, Rc1, Rd9), (Ra19, Rb2, Rc1, Rd10), (Ra19, Rb2, Rc1, Rd11), (Ra19, Rb2, Rc1, Rd12), (Ra19, Rb2, Rc1, Rd13) ), (Ra19, Rb2, Rc1, Rd14), (Ra19, Rb2, Rc1, Rd15), (Ra19, Rb2, Rc1, Rd16), (Ra19, Rb2, Rc1, Rd17), (Ra19, Rb2, Rc1, Rd18) ), (Ra19, Rb2, Rc1, Rd19), (Ra19, Rb2, Rc1, Rd20), (Ra19, Rb2, Rc1, Rd21), (Ra19, Rb2, Rc1, Rd22), (Ra19, Rb2, Rc1, Rd23) ), (Ra19, Rb2, Rc1, Rd24) , (Ra19, Rb2, Rc1, Rd25), (Ra19, Rb2, Rc1, Rd27), (Ra19, Rb2, Rc1, Rd28), (Ra19, Rb2, Rc1, Rd29) , (Ra19, Rb2, Rc2, Rd1), (Ra19, Rb2, Rc2, Rd2), (Ra19, Rb2, Rc2, Rd3), (Ra19, Rb2, Rc2, Rd4), (Ra19, Rb2, Rc2, Rd5) , (Ra19, Rb2, Rc2, Rd6), (Ra19, Rb2, Rc2, Rd7), (Ra19, Rb2, Rc2, Rd8), (Ra19, Rb2, Rc2, Rd9), (Ra19, Rb2, Rc2, Rd10) , (Ra19, Rb2, Rc2, Rd11), (Ra19, Rb2, Rc2, Rd13), (Ra19, Rb2, Rc2, Rd14), (Ra19, Rb2, Rc2, Rd15) , (Ra19, Rb2, Rc2, Rd16), (Ra19, Rb2, Rc2, Rd17), (Ra19, Rb2, Rc2, Rd18), (Ra19, Rb2, Rc2, Rd19), (Ra19, Rb2, Rc2, Rd20) , (Ra19, Rb2, Rc2, Rd21), (Ra19, Rb2, Rc2, Rd22), (Ra19, Rb2, Rc2, Rd23), (Ra19, Rb2, Rc2, Rd24), (Ra19, Rb2, Rc2, Rd25) , (Ra19, Rb2, Rc2, Rd26), (Ra19, Rb2, Rc2, Rd27), (Ra19, Rb2, Rc2, Rd28), (Ra19, Rb2, Rc2, Rd29), (Ra19, Rb2, Rc3, Rd1) , (Ra19, Rb2, Rc3, Rd2), (Ra19, Rb2, Rc3, Rd3), (Ra19, Rb2, Rc3, Rd4), (Ra19, Rb2, Rc3, Rd5), (Ra19, Rb2, Rc3, Rd6), (Ra19, Rb2, Rc3, Rd7), (Ra19, Rb2, Rc3, Rd8), (Ra19, Rb2, Rc3, Rd9), (Ra19, Rb2, Rc3, Rd10), (Ra19, Rb2, Rc3, Rd11), (Ra19, Rb2, Rc3, Rd12), (Ra19, Rb2, Rc3, Rd13), (Ra19, Rb2, Rc3, Rd14), (Ra19, Rb2, Rc3, Rd15), (Ra19, Rb2, Rc3, Rd16), (Ra19, Rb2, Rc3, Rd17), (Ra19, Rb2, Rc3, Rd18), (Ra19, RaRb2, Rc3, Rd19), (Ra19, Rb2, Rc3, Rd20), (Ra19, Rb2, Rc3, Rd21),

(Ra19, Rb2, Rc3, Rd22), (Ra19, Rb2, Rc3, Rd23), (Ra19, 3Rb2, Rc3, Rd24), (Ra19, Rb2, Rc3, Rd25), (Ra19, Rb2, Rc3, Rd26), (Ra19, Rb2, Rc3, Rd27), (Ra19, Rb2, Rc3, (Rd28), (Ra19, 3Rb2, Rc3, Rd29), (Ra19, Rb2, Rc4, Rd1), (Ra19, Rb2, Rc4, Rd2), (Ra19, Rb2, Rc4, Rd3), (Ra19, Rb2, Rc4, Rd4), (Ra19, Rb2, Rc4, Rd5), (Ra19, Rb2, Rc4, Rd6), (Ra19, Rb2, Rc4, Rd7), (Ra19, Rb2, Rc4, Rd8), (Ra19, Rb2, Rc4, Rd9), (Ra19, Rb2, Rc4, Rd10), (Ra19, Rb2, Rc4, Rd11), (Ra19, Rb2, Rc4, Rd12), (Ra19, Rb2, Rc4, Rd13), (Ra19, Rb2, Rc4, Rd15), (Ra19, Rb2, Rc4, Rd16), (Ra19, Rb2, Rc4, Rd17), (Ra19, Rb2, Rc4, Rd18), (Ra19, Rb2, Rc4, Rd19), (Ra19, Rb2, Rc4, Rd20), (Ra19, Rb2, Rc4, Rd21), (Ra19, Rb2, Rc4, Rd22), (Ra19, Rb2, Rc4, Rd23), (Ra19, Rb2, Rc4, Rd25), (Ra19, Rb2, Rc4, Rd26), (Ra19, Rb2, Rc4, Rd27), (Ra19, Rb2, Rc4,4Rd28) (Ra19, Rb2, Rc4, Rd29), (Ra19, Rb2, Rc5, Rd1), (Ra19, Rb2, Rc5, Rd2), (Ra19, Rb2, Rc5, Rd3), (Ra19, Rb2, Rc5, Rd4), (Ra19, Rb2, Rc5, Rd5), (Ra19, Rb2, Rc5, Rd6), (Ra19, Rb2, Rc5, Rd7), (Ra19, Rb2, Rc5, Rd8), (Ra19, Rb2, Rc5, Rd9), (Ra19, Rb2, Rc5, Rd10), (Ra19, Rb2, Rc5, Rd11), (Ra19, Rb2, Rc5, Rd12), (Ra19, Rb2, Rc5, Rd13), (Ra19, Rb2, Rc5, Rd14), (Ra19, Rb2, Rc5, Rd15), (Ra19, Rb2, Rc5, Rd16), (Ra19,) Rb2, Rc5, Rd17), (Ra19, Rb2, Rc5, Rd18), (Ra19, Rb2, Rc5, Rd19), (Ra19, Rb2, Rc5, Rd20), (Ra19, Rb2, Rc5, Rd21), (Ra19, Rb2, Rc5, Rd22), (Ra19, Rb2, Rc5, Rd23), (Ra19, Rb2, Rc5, Rd24), (Ra19, Rb2, Rc5, Rd25), (Ra19, Rb2, Rc5, Rd26), (Ra19, Rb2, 27Rc5, Rd27), (Ra19, Rb2, (Rc5, bRd28), (Ra19, Rb2, Rc5, Rd29), (Ra20, Rb1, Rc1, Rd1), (Ra20, Rb1, Rc1, Rd2), (Ra20, Rb1, Rc1, Rd3), (Ra20, Rb1, Rc1, Rd4), (Ra20, Rb1, Rc1, Rd5), (Ra20, Rb1, Rc1, Rd6), (Ra20, Rb1, Rc1, Rd7), (Ra20, Rb1, Rc1, Rd8), (Ra20, Rb1, Rc1, Rd10), (Ra20, Rb1, Rc1, Rd10), (Ra20, Rb1, Rc1, Rd11), (Ra20, Rb1, Rc1, Rd12), (Ra20, Rb1, Rc1, Rd13), (Ra20, Rb1, Rc1, Rd14), (Ra20, Rb1, Rc1, Rd15), (Ra20, Rb1, Rc1, Rd16), (Ra20, Rb1, Rc1, Rd17), (Ra20, Rb1, Rc1, Rd18), (Ra20, Rb1, Rc1, Rd19), (Ra20, Rb1, Rc1, Rd20), (Ra20, Rb1, Rc1, Rd21), (Ra20, Rb1, Rc1, Rd22), (Ra20, Rb1, Rc1, Rd23), (Ra20, Rb1, Rc1, Rd24), (Ra20, Rb1, Rc1, Rd25), (Ra20, Rb1, Rc1, Rd26), (Ra20, Rb1, Rc1, Rd27), (Ra20, Rb1, Rc1, Rd28), (Ra20, Rb1, Rc1, Rd29), (Ra20, Rb1, Rc2, Rd1), (Ra20, Rb1, Rc2, Rd2), (Ra20, Rb1, Rc2, Rd3), (Ra20, Rb1, Rc2, Rd4), (Ra20, Rb1, Rc2, Rd5), (Ra20, Rb1, Rc2, Rd6), (Ra20, Rb1, Rc2, Rd7), (Ra20, Rb1, Rc2, Rd8), (Ra20, Rb1, Rc2, Rd9), (Ra20, Rb1, Rc2, Rd10), (Ra20, Rb1, Rc2, Rd11), (Ra20, Rb1, Rc2, Rd12), (Ra20, Rb1, Rc2, Rd13), (Ra20, Rb 1, Rc2, Rd14), (Ra20, Rb1, Rc2, Rd15), (Ra20, Rb1, Rc2, Rd16), (Ra20, Rb1, Rc2, Rd17), (Ra20, Rb1, Rc2, Rd18), (Ra20, Rb1, Rc2, Rd19), (Ra20, Rb1, Rc2, Rd20), (Ra20, Rb1, Rc2, Rd21), (Ra20, Rb1, Rc2, Rd22), (Ra20, Rb1, Rc2, Rd23), (Ra20, Rb1, Rc2, Rd24), (Ra20, Rb1, Rc2, Rd25), (Ra20, Rb1, Rc2, Rd26), (Ra20, Rb1, Rc2, Rd27), (Ra20, Rb1, Rc2, Rd28), (Ra20, Rb1, Rc2, Rd29), (Ra20, Rb1, Rc3, Rd1), (Ra20, Rb1, Rc3, Rd2), (Ra20, Rb1, Rc3, Rd3), (Ra20, Rb1, Rc3, Rd4), (Ra20, Rb1, Rc3, Rd5), (Ra20, Rb1, Rc3, Rd6), (Ra20, Rb1, Rc3, Rd7), (Ra20, Rb1, Rc3, Rd8), (Ra20, Rb1, Rc3, Rd9), (Ra20, Rb1, Rc3, Rd10), (Ra20, Rb1, Rc3, Rd11), (Ra20, Rb1, Rc3, Rd12), (Ra20, Rb1, Rc3, Rd13), (Ra20, Rb1, Rc3, Rd14), (Ra20, Rb1, Rc3, Rd15), (Ra20, Rb1, Rc3, Rd16), (Ra20, Rb1, Rc3, Rd17), (Ra20, Rb1, Rc3, Rd18), (Ra20, Rb1, Rc3, Rd19), (Ra20, Rb1, Rc3, Rd20), (Ra20, Rb1 , Rc3, Rd21), (Ra20, Rb1, Rc3, Rd23), (Ra20, Rb1, Rc3, Rd24), (Ra20, Rb1, Rc3, Rd25), (Ra20, Rb1) , Rc3, Rd26), (Ra20, Rb1, Rc3, Rd27), (Ra20, Rb1, Rc3, Rd28), (Ra20, Rb1, Rc3, Rd29), (Ra20, Rb1, Rc4, Rd1), (Ra20, Rb1) , Rc4, Rd2), (Ra20, Rb1, Rd4), (Ra20, Rb1, Rc4, Rd5), (Ra20, Rb1, Rc4, 、 Rd6), (Ra20, Rb1) , Rc4, Rd7), (Ra20, Rb1, Rc4, Rd8), (Ra20, Rb1, Rc4, Rd9), (Ra20, Rb1, Rc4, Rd10), (Ra20, Rb1, Rc4, Rd11), (Ra20, Rb1) , Rc4, Rd12), (Ra20, Rb1, Rc4, Rd13), (Ra20, Rb1, Rc4, Rd14), (Ra20, Rb1, Rc4, Rd15), (Ra20, Rb1, Rc4, Rd16), (Ra20, Rb1) , Rc4, Rd17), (Ra20,20Rb1, Rc4, Rd18), (Ra20, Rb1, Rc4, Rd20), (Ra20, Rb1, Rc4, Rd21), (Ra20, Rb1) , Rc4, Rd22), (Ra20, Rb1, Rc4, Rd23), (Ra20, Rb1, Rc4, Rd25), (Ra20, Rb1, Rc4, Rd26), (Ra20, Rb1) , Rc4, Rd27), (Ra20, Rb1, Rc4, Rd28), (Ra20, Rb1, Rc4, Rd29), (Ra20, Rb1, Rc5, Rd1), (Ra20, Rb1, Rc5, Rd2), (Ra20, Rb1, Rc5, Rd3), (Ra20, Rb1, Rc5, Rd4), (Ra20, Rb1, Rc5, Rd5), (Ra20, Rb1, Rc5, Rd7), (Ra20, Rb1, Rc5, Rd8), (Ra20, Rb1, Rc5, Rd9), (Ra20, Rb1, Rc5, Rd10), (Ra20, Rb1, Rc5, Rd11), (Ra20, Rb1, Rc5, Rd12), (Ra20, Rb1, Rc5, Rd13), (Ra20, Rb1, Rc5, Rd14), (Ra20, Rb1, Rc5, Rd15), (Ra20, Rb1, Rc5, Rd16), (Ra20, Rb1, Rc5, Rd17), (Ra20, Rb1, Rc5, Rd18), (Ra20, Rb1, Rc5, Rd19), (Ra20, Rb1, Rc5, Rd20), (Ra20, Rb1, Rc5, Rd21), (Ra20, Rb1, Rc5, Rd22), (Ra20, Rb1, Rc5, Rd23), (Ra20, Rb1, Rc5, Rd24), (Ra20, Rb1, Rc5, Rd25), (Ra20, Rb1, Rc5, Rd26), (Ra20, Rb1, Rc5, Rd27), (Ra20, Rb1, Rc5, Rd28), (Ra20, Rb1, Rc5, Rd29), (Ra20, Rb2, Rc1, Rd1), (Ra20, Rb2, Rc1, Rd2), (Ra20, Rb2, Rc1, Rd3), (Ra20, Rb2, Rc1, Rd4), (Ra20, Rb2, Rc1, Rd5), (Ra20, Rb2, Rc1, Rd6), (Ra20, Rb2, Rc1, Rd7), (Ra20, Rb2, Rc1, Rd8), (Ra20, Rb2, Rc1, Rd9), (Ra20, Rb2, Rc1, Rd10), (Ra20, Rb2, Rc1, Rd11), (Ra20, Rb2, Rc1, Rd12), (Ra20, Rb2, Rc1, Rd13), (Ra20, Rb2, Rc1, Rd14), (Ra20, Rb2, Rc1, Rd15), (Ra20, Rb2, Rc1, Rd16), (Ra20, Rb2, Rc1, Rd17), (Ra20, Rb2, Rc1, Rd18), (Ra20, Rb2, Rc1, Rd19), (Ra20, Rb2, Rc1, Rd20), (Ra20, Rb2, Rc1, Rd21), (Ra20, Rb2, Rc1, Rd22), (Ra20, Rb2, Rc1, Rd23), (Ra20, Rb2, Rc1, Rd24), (Ra20, Rb2, Rc1, Rd25), (Ra20, Rb2, Rc1, Rd26), (Ra20, Rb2, Rc1, Rd27), (Ra20, Rb2, Rc1, Rd28), (Ra20, Rb2, Rc1, Rd29), (Ra20, Rb2, Rc2, Rd1), (Ra20, Rb2, Rc2, Rd2), (Ra20, Rb2, Rc2, Rd3), (Ra20, Rb2, Rc2, Rd4), (Ra20, Rb2, Rc2, Rd5), (Ra20, Rb2, Rc2, Rd6), (Ra20, Rb2, Rc2, Rd7), (Ra20, Rb2, Rc2, Rd8), (Ra20, Rb2, Rc2, Rd9), (Ra20, Rb2, Rc2, Rd10), (Ra20, Rb2, Rc2, Rd11), (Ra20, Rb2, Rc2, Rd12), (Ra20, Rb2, Rc2, Rd1 3), (Ra20, Rb2, Rc2, Rd14), (Ra20, Rb2, Rc2, Rd15), (Ra20, Rb2, Rc2, Rd16), (Ra20, Rb2, Rc2, Rd17), (Ra20, Rb2, Rc2, Rd18),

(Ra20, Rb2, Rc2, Rd19), (Ra20, Rb2, Rc2, Rd21), (Ra20, Rb2, Rc2, Rd22), (Ra20, Rb2, Rc2, Rd23), (Ra20, Rb2, Rc2, Rd24), (Ra20, Rb2, Rc2, Rd26), (Ra20, Rb2, Rc2, Rd27), (Ra20, Rb2, Rc2, Rd28), (Ra20, Rb2, Rc2, Rd29), (Ra20, Rb2, Rc3, Rd1), (Ra20, Rb2, Rc3, Rd2), (Ra20, Rb2, Rc3, Rd3), (Ra20, Rb2, Rc3, Rd4), (Ra20, Rb2, Rc3, Rd5), (Ra20, Rb2, Rc3, (Rd6), (Ra20, Rb2, Rc3, Rd7), (Ra20, Rb2, Rc3, Rd8), (Ra20, Rb2, Rc3, Rd9), (Ra20, Rb2, Rc3, Rd10), (Ra20, Rb2, Rc3, Rd11), (Ra20, Rb2, Rc3, Rd12), (Ra20, Rb2, Rc3, Rd13), (Ra20, Rb2, Rc3, Rd14), (Ra20, Rb2, Rc3, Rd15), (Ra20, Rb2, Rc3, Rd16), (Ra20, Rb2, Rc3, Rd17), (Ra20, Rb2, Rc3, Rd18), (Ra20, Rb2, Rc3, Rd19), (Ra20, Rb2, Rc3, Rd20), (Ra20, Rb2, Rc3, Rd21), (Ra20, Rb2, Rc3, Rd22), (Ra20, Rb2, Rc3, Rd23), (Ra20, Rb2, Rc3, Rd24), (Ra20, Rb2, Rc3, Rd25) (Ra20, Rb2, Rc3, Rd26), (Ra20, Rb2, Rc3, (Rd27), (Ra20, 3Rb2, Rc3, Rd28), (Ra20, Rb2, Rc3, Rd29), (Ra20, Rb2, Rc4, Rd1), (Ra20, Rb2, Rc4, Rd2), (Ra20, Rb2, Rc4, Rd3), (Ra20, Rb2, Rc4, Rd4), (Ra20, Rb2, Rc4, Rd5), (Ra20, Rb2, Rc4, Rd6), (Ra20, Rb2, Rc4, Rd7), (Ra20, Rb2, Rc4, Rd8), (Ra20, Rb2, Rc4, Rd9), (Ra20, Rb2, Rc4, Rd10), (Ra20, Rb2, Rc4, Rd11), (Ra20, Rb2, Rc4, Rd12), (Ra20, Rb2, Rc4, Rd13), (Ra20, Rb2,20Rc4, bRd14), (Ra20, Rb2, Rc4, Rd15), (Ra20, Rb2, Rc4, Rd16), (Ra20, Rb2, Rc4, Rd17), (Ra20, Rb2, Rc4, Rd18), (Ra20, Rb2, Rc4, Rd19), (Ra20, Rb2, Rc4, Rd20), (Ra20, Rb2, Rc4, Rd21), (Ra20, Rb2, Rc4, Rd22), (Ra20, Rb2, Rc4, Rd23), (Ra20, Rb2, Rc4, Rd24), (Ra20, Rb2, Rc4, Rd25), (Ra20, Rb2, Rc4, Rd26), (Ra20, Rb2, Rc4, Rd27), (Ra20, Rb2, Rc4, Rd28), (Ra20, Rb2, Rc4, Rd29), (Ra20, Rb2, Rc5, Rd1), (Ra20, Rb2, Rc5, Rd2), (Ra20, Rb2, Rc5, Rd3), (Ra 20, Rb2, Rc5, Rd4), (Ra20, Rb2, Rc5, Rd5), (Ra20, Rb2, Rc5, Rd6), (Ra20, Rb2, Rc5, Rd7), (Ra20, Rb2, Rc5, Rd8), (Ra20, Rb2, Rc5, Rd9), (Ra20, Rb2, Rc5, Rd10), (Ra20, Rb2, Rc5, Rd11), (Ra20, Rb2, Rc5, Rd12), (Ra20, Rb2, Rc5, Rd13), (Ra20, Rb2, Rc5, Rd14), (Ra20, Rb2, Rc5, Rd15), (Ra20, Rb2, Rc5, Rd16), (Ra20, Rb2, Rc5, Rd17), (Ra20, Rb2, Rc5, Rd18), (Ra20, bRb2, 5Rc5, Rd19), (Ra20, Rb2, Rc5, Rd20), (Ra20, Rb2, Rc5, Rd21), (Ra20, Rb2, Rc5, Rd22), (Ra20, Rb2, Rc5, Rd23), Ra20, Rb2, Rc5, 24Rd24), (Ra20, Rb2, Rc5, Rd25), (Ra20, Rb2, Rc5, Rd26), (Ra20, Rb2, Rc5, Rd27), (Ra20, Rb2, Rc5, Rd28), Ra20, Rb2, Rc5, Rd29), (Ra21, Rb1, Rc1, Rd1), (Ra21, Rb1, Rc1, Rd2), (Ra21, Rb1, Rc1, Rd3), (Ra21, Rb1, Rc1, Rd4), ( Ra21, Rb1, Rc1, Rd5), (Ra21, Rb1, Rd1, (Rd7), (Ra21, Rb1, Rc1, Rd8), (Ra21, Rb1, Rc1, Rd9), ( Ra21, Rb1, Rc1, Rd10), (Ra21, Rb 1, Rc1, Rd11), (Ra21, Rb1, Rc1, Rd12), (Ra21, Rb1, Rc1, Rd13), (Ra21, Rb1, Rc1, Rd14), (Ra21, Rb1, Rc1, Rd15), (Ra21, Rb1, Rc1, Rd16), (Ra21, Rb1, Rc1, Rd17), (Ra21, Rb1, Rc1, Rd19), (Ra21, Rb1, Rc1, Rd19), (Ra21, Rb1, Rc1, Rd20), (Ra21, Rb1, Rc1, Rd21), (Ra21, Rb1, Rc1, Rd22), (Ra21, Rb1, Rc1, Rd23), (Ra21, Rb1, Rc1, Rd24), (Ra21, Rb1, Rc1, Rd25), (Ra21, Rb1, Rc1, Rd26), (Ra21, Rb1, Rc1, Rd27), (Ra21, Rb1, Rc1, Rd28), (Ra21, Rb1, Rc1, Rd29), (Ra21, Rb1, Rc2, Rd1), (Ra21, Rb1, Rc2, Rd2), (Ra21, Rb1, Rc2, Rd3), (Ra21, Rb1, Rc2, Rd4), (Ra21, Rb1, Rc2, Rd5), (Ra21, Rb1, Rc2, Rd6), (Ra21, Rb1, Rc2, Rd7), (Ra21, Rb1, Rc2, Rd8), (Ra21, Rb1, Rc2, Rd9), (Ra21, Rb1, Rc2, Rd10), (Ra21, Rb1, Rc2, Rd11), (Ra21, Rb1, Rc2, Rd12), (Ra21, Rb1, Rc2, Rd13), (Ra21, Rb1, Rc2, Rd14), (Ra21, Rb1, Rc2, Rd15), (Ra21, Rb1, Rc2, Rd16), (Ra21, Rb1, Rc2, Rd17), (Ra21, Rb1 , Rc2, Rd18), (Ra21, Rb1, Rc2, Rd19), (Ra21, Rb1, Rc2, Rd20), (Ra21, Rb1, Rc2, Rd21), (Ra21, Rb1, Rc2, Rd22), (Ra21, Rb1 , Rc2, Rd23), (Ra21,21Rb1, Rc2, Rd25), (Ra21, Rb1, Rc2, Rd26), (Ra21, Rb1, Rc2, Rd27), (Ra21, Rb1) , Rc2, Rd28), (Ra21, Rb1, Rc2, Rd29), (Ra21, Rb1, Rc3, Rd1), (Ra21, Rb1, Rc3, Rd2), (Ra21, Rb1, Rc3, Rd3), (Ra21, Rb1) , Rc3, Rd4), (Ra21, Rb1, Rc3, Rd5), (Ra21, Rb1, Rc3, Rd6), (Ra21, Rb1, Rc3, Rd7), (Ra21, Rb1, Rc3, Rd8), (Ra21, Rb1) , Rc3, Rd9), (Ra21, Rb1, Rc3, Rd10), (Ra21, Rb1, Rc3, Rd11), (Ra21, Rb1, Rc3, Rd12), (Ra21, Rb1, Rc3, Rd13), (Ra21, Rb1) , Rc3, Rd14), (Ra21, Rb1, Rc3, Rd16), (Ra21, Rb1, Rc3, Rd17), (Ra21, Rb1, Rc3, Rd18), (Ra21, Rb1) , Rc3, dRd19), (Ra21, Rb1, Rc3, Rd20), (Ra21, Rb1, Rc3, Rd21), (Ra21, Rb1, Rc3, Rd22), (Ra21, Rb1, Rc3, Rd23), (Ra21, Rb1) , Rc3, Rd24), (Ra21, Rb1, Rc3, Rd25), (Ra21, Rb1, Rc3, Rd26), (Ra21, Rb1, Rc3, Rd27), (Ra21, Rb1, Rc3, Rd28), (Ra21, Rb1, Rc3, Rd29), (Ra21, Rb1, Rc4, Rd1), (Ra21, Rb1, Rd4), (Ra21, Rb1, Rc4, Rd4), (Ra21, Rb1, Rc4, Rd5), (Ra21, Rb1, Rc4, Rd6), (Ra21, Rb1, Rc4, Rd7), (Ra21, Rb1, Rc4, Rd8), (Ra21, Rb1, Rc4, Rd9), (Ra21, Rb1, Rc4, Rd10), (Ra21, Rb1, Rc4, Rd11), (Ra21, Rb1, Rc4, Rd12), (Ra21, Rb1, Rc4, Rd13), (Ra21, Rb1, Rc4, Rd14), (Ra21, Rb1, Rc4, Rd15), (Ra21, Rb1, Rc4, Rd16), (Ra21, Rb1, Rc4, Rd17), (Ra21, Rb1, Rc4, Rd18), (Ra21, Rb1, Rc4, Rd19), (Ra21, Rb1, Rc4, Rd20), (Ra21, Rb1, Rc4, Rd21), (Ra21, Rb1, Rc4, Rd22), (Ra21, Rb1, Rc4, Rd23), (Ra21, Rb1, Rc4, Rd24), (Ra21, Rb1, Rc4, Rd25), (Ra21, Rb1, Rc4, Rd26), (Ra21, Rb1, Rc4, Rd27), (Ra21, Rb1, Rc4, Rd28), (Ra21, Rb1, Rc4, Rd29), (Ra21, Rb1, Rc5, Rd1), (Ra21, Rb1, Rc5, Rd2), (Ra21, Rb1, R c5, Rd3), (Ra21, Rb1, Rc5, Rd4), (Ra21, Rb1, Rc5, Rd5), (Ra21, Rb1, Rc5, Rd6), (Ra21, Rb1, Rc5, Rd7), (Ra21, Rb1, Rc5, Rd8), (Ra21, Rb1, Rc5, Rd9), (Ra21, Rb1, Rc5, Rd10), (Ra21, Rb1, Rc5, Rd11), (Ra21, Rb1, Rc5, Rd12), (Ra21, Rb1, Rc5, Rd13), (Ra21, Rb1, Rc5, Rd14), (Ra21, Rb1, Rc5, Rd15), (Ra21, Rb1, Rc5, Rd16), (Ra21, Rb1, Rc5, Rd17), (Ra21, Rb1, Rc5, Rd18), (Ra21, Rb1, Rc5, Rd19), (Ra21, Rb1, Rc5, Rd20), (Ra21, Rb1, Rc5, Rd21), (Ra21, Rb1, Rc5, Rd22), (Ra21, Rb1, Rc5, Rd23), (Ra21, Rb1, Rc5, Rd24), (Ra21, Rb1, Rc5, Rd25), (Ra21, Rb1, Rc5, Rd26), (Ra21, Rb1, Rc5, Rd27), (Ra21, Rb1, Rc5, Rd28), (Ra21, Rb1, Rc5, Rd29), (Ra21, Rb2, Rc1, Rd1), (Ra21, Rb2, Rc1, Rd2), (Ra21, Rb2, Rc1, Rd3), (Ra21, Rb2, Rc1, Rd4), (Ra21, Rb2, Rc1, Rd5), (Ra21, Rb2, Rc1, Rd6), (Ra21, Rb2, Rc1, Rd7), (Ra21, Rb2, Rc1, Rd8), (Ra21, Rb2, Rc1, Rd9), (Ra21, Rb2, Rc1, Rd1 0), (Ra21, Rb2, Rc1, Rd11), (Ra21, Rb2, Rc1, Rd12), (Ra21, Rb2, Rc1, Rd13), (Ra21, Rb2, Rc1, Rd14), (Ra21, Rb2, Rc1, Rd15), (Ra21, Rb2, Rc1, Rd16), (Ra21, Rb2, Rc1, Rd17), (Ra21, Rb2, Rc1, Rd18), (Ra21, Rb2, Rc1, Rd19), (Ra21, Rb2, Rc1, Rd20), (Ra21, Rb2, Rc1, Rd21), (Ra21, Rb2, Rc1, Rd22), (Ra21, Rb2, Rc1, Rd23), (Ra21, Rb2, Rc1, Rd24), (Ra21, Rb2, Rc1, Rd25), (Ra21, Rb2, Rc1, Rd26), (Ra21, Rb2, Rc1, Rd27), (Ra21, Rb2, Rc1, Rd28), (Ra21, Rb2, Rc1, Rd29), (Ra21, Rb2, Rc2, Rd1), (Ra21, Rb2, Rc2, Rd2), (Ra21, Rb2, Rc2, Rd3), (Ra21, Rb2, Rc2, Rd4), (Ra21, Rb2, Rc2, Rd5), (Ra21, Rb2, Rc2, Rd6), (Ra21, Rb2, Rc2, Rd7), (Ra21, Rb2, Rc2, Rd8), (Ra21, Rb2, Rc2, Rd9), (Ra21, Rb2, Rc2, Rd10), (Ra21, Rb2, Rc2, Rd11), (Ra21, Rb2, Rc2, Rd12), (Ra21, Rb2, Rc2, Rd13), (Ra21, Rb2, Rc2, Rd14), (Ra21, Rb2, Rc2, Rd15), (Ra21, Rb2, Rc2, Rd16), (Ra21, Rb2, Rc2, Rd17 ), (Ra21, Rb2, Rc2, Rd18), (Ra21, Rb2, Rc2, Rd19), (Ra21, Rb2, Rc2, Rd20), (Ra21, Rb2, Rc2, Rd21), (Ra21, Rb2, Rc2, Rd22) ), (Ra21, Rb2, Rc2, Rd23), (Ra21, Rb2, Rc2, Rd24), (Ra21, Rb2, Rc2, Rd25), (Ra21, Rb2, Rc2, Rd26), (Ra21, Rb2, Rc2, Rd27) ), (Ra21, Rb2, Rc2, Rd28), (Ra21, Rb2, Rc2, Rd29), (Ra21, Rb2, Rc3, Rd1), (Ra21, Rb2, Rc3, Rd2), (Ra21, Rb2, Rc3, Rd3) ), (Ra21, Rb2, Rc3, Rd4), (Ra21, Rb2, Rc3, Rd5), (Ra21, Rb2, Rc3, Rd6), (Ra21, Rb2, Rc3, Rd7), (Ra21, Rb2, Rc3, Rd8) ), (Ra21, Rb2, Rc3, Rd9), (Ra21, Rb2, Rc3, Rd10), (Ra21, Rb2, Rc3, Rd11), (Ra21, Rb2, Rc3, Rd12), (Ra21, Rb2, Rd3, Rd13) ), (Ra21, Rb2, Rc3, Rd14), (Ra21, Rb2, Rc3, Rd15), (Ra21, Rb2, Rc3, Rd16), (Ra21, Rb2, Rc3, Rd17), (Ra21, Rb2, Rc3, Rd18) ), (Ra21, Rb2, Rc3, Rd19), (Ra21, Rb2, Rc3, Rd20), (Ra21, Rb2, Rc3, Rd21), (Ra21, Rb2, Rc3, Rd22), (Ra21, Rb2, Rc3, Rd23) ), (Ra21, Rb2, Rc3, Rd24) , (Ra21, Rb2, Rc3, Rd25), (Ra21, Rb2, Rc3, Rd26), (Ra21, Rb2, Rc3, Rd27), (Ra21, Rb2, Rc3, Rd28), (Ra21, Rb2, Rc3, Rd29) , (Ra21, Rb2, Rc4, Rd1), (Ra21, Rb2, Rc4, Rd2), (Ra21, Rb2, Rc4, Rd3), (Ra21, Rb2, Rc4, Rd4), (Ra21, Rb2, Rc4, Rd5) , (Ra21, Rb2, Rc4, Rd6), (Ra21, Rb2, Rc4, Rd7), (Ra21, Rb2, Rc4, Rd8), (Ra21, Rb2, Rc4, Rd9), (Ra21, Rb2, Rc4, Rd10) , (Ra21, Rb2, Rc4, Rd11), (Ra21, Rb2, Rc4, Rd12), (Ra21, Rb2, Rc4, Rd13), (Ra21, Rb2, Rc4, Rd14), (Ra21, Rb2, Rc4, Rd15) , (Ra21, Rb2, Rc4, Rd16), (Ra21, Rb2, Rc4, Rd17), (Ra21, Rb2, Rc4, Rd18), (Ra21, Rb2, Rc4, Rd19), (Ra21, Rb2, Rc4, Rd20) , (Ra21, Rb2, Rc4, Rd21), (Ra21, Rb2, Rc4, (Rd22), (Ra21, Rb2, Rc4, Rd23), (Ra21, Rb2, Rc4, Rd24), (Ra21, Rb2, Rc4, Rd25) , (Ra21, Rb2, Rc4, Rd26), (Ra21, Rb2, Rc4, Rd27), (Ra21, Rb2, Rc4, Rd28), (Ra21, Rb2, Rc4, Rd29), (Ra21, Rb2, Rc5, Rd1) , (Ra21, Rb2, Rc5, Rd2), (Ra21, Rb2, Rc5, Rd3), (Ra21, Rb2, Rc5, Rd4), (Ra21, Rb2, Rc5, Rd5), (Ra21, Rb2, Rc5, Rd6), (Ra21, Rb2, Rc5, Rd7), (Ra21, Rb2, Rc5, Rd8), (Ra21, Rb2, Rc5, Rd9), (Ra21, Rb2, Rc5, Rd10), (Ra21, Rb2, Rc5, Rd11), (Ra21, Rb2, Rc5, Rd12), (Ra21, Rb2, Rc5, Rd13), (Ra21, Rb2, Rc5, Rd14), (Ra21, Rb2, Rc5, Rd15), (Ra21, Rb2, Rc5, Rd16), (Ra21, Rb2, Rc5, Rd17), (Ra21, Rb2, Rc5, Rd18), (Ra21, Rb2, Rc5, Rd19), (Ra21, Rb2, Rc5, Rd20), (Ra21, Rb2, Rc5, Rd21),

(Ra21, Rb2, Rc5, Rd22), (Ra21, Rb2, Rc5, Rd23), (Ra21, Rb2, Rc5, Rd24), (Ra21, Rb2, Rc5, Rd25), (Ra21, Rb2, Rc5, Rd26), (Ra21, Rb2, Rc5, Rd27), (Ra21, Rb2, Rc5, Rd28), (Ra21, Rb2,21Rc5, Rd29), (Ra22, Rb1, Rc1, Rd1), (Ra22, Rb1, Rc1, Rd2), (Ra22, Rb1, Rc1, Rd3), (Ra22, Rb1, Rc1, Rd5), (Ra22, Rb1, Rc1, Rd6), (Ra22, Rb1, Rc1, Rd7), (Ra22, Rb1, Rc1, Rd8), (Ra22, Rb1, Rc1, Rd9), (Ra22, Rb1, Rc1, Rd10), (Ra22, Rb1, Rc1, Rd11), (Ra22, Rb1, Rc1, Rd12), (Ra22, Rb1, Rc1, Rd13), (Ra22, Rb1, Rc1, Rd15), (Ra22, Rb1, Rc1, Rd16), (Ra22, Rb1, Rc1, Rd17), (Ra22, Rb1, Rc1, Rd18), (Ra22, Rb1, Rc1, Rd20), (Ra22, Rb1, Rc1, Rd21), (Ra22, Rb1, Rc1, Rd22), (Ra22, Rb1, Rc1, Rd23), (Ra22, Rb1, Rc1, Rd25), (Ra22, Rb1, Rc1, Rd26), (Ra22, Rb1, Rc1, Rd27), (Ra22, Rb1, Rc1, Rd28) (Ra22, Rb1, Rc1, Rd29), (Ra22, Rb1, Rc2, Rd2), (Ra22, Rb1, Rc2, Rd3), (Ra22, Rb1, Rc2, Rd4), (Ra22, Rb1, Rc2, Rd5), (Ra22, Rb1, Rc2, Rd7), (Ra22, Rb1, Rc2, Rd8), (Ra22, Rb1, Rc2, Rd9), (Ra22, Rb1, Rc2, Rd10), (Ra22, Rb1, Rc2, Rd12), (Ra22, Rb1, Rc2, Rd13), (Ra22, Rb1, Rc2, Rd14), (Ra22, Rb1, Rc2, Rd15), (Ra22, Rb1, Rc2, Rd17), (Ra22, Rb1, Rc2, Rd18), (Ra22, Rb1, Rc2, Rd19), (Ra22, Rb1, Rc2, Rd20), (Ra22, Rb1, Rc2, Rd21), (Ra22, Rb1, Rc2, Rd22), (Ra22, Rb1, Rc2, Rd23), (Ra22, Rb1, Rc2, Rd24), (Ra22, Rb1, Rc2, Rd25), (Ra22, Rb1, Rc2, Rd27), (Ra22, Rb1, Rc2, Rd28), (Ra22, Rb1, Rc2, Rd29), (Ra22, Rb1, Rc3, Rd1), (Ra22, Rb1, Rc3, Rd2), (Ra22, Rb1, Rc3, Rd3), (Ra22, Rb1, 、 Rc3, Rd4), (Ra22, Rb1, Rc3, Rd5), (Ra22, Rb1, Rc3, Rd6), (Ra22, Rb1, Rc3, Rd7), (Ra22, Rb1, Rc3, Rd8), (Ra22, Rb1, Rc3, Rd9), (Ra22, Rb1, Rc3, Rd10), (Ra22, Rb1, Rc3, Rd11), (Ra22, Rb1, Rc3, Rd12), (Ra22, Rb1, Rc3, Rd13), (Ra22, Rb1, Rc3, Rd14), (Ra22, Rb1, Rc3, Rd15), (Ra22, Rb1, Rc3, Rd16), (Ra22, Rb1, Rc3, Rd17), (Ra22, Rb1, Rc3, Rd18), (Ra22, Rb1, Rc3, Rd19), (Ra22, Rb1, Rc3, Rd20), (Ra22, Rb1, Rc3, Rd21), (Ra22, Rb1, Rc3, Rd22), (Ra22, Rb1, Rc3, Rd23), (Ra22, Rb1, Rc3, Rd24), (Ra22, Rb1, Rc3, Rd25), (Ra22, Rb1, Rc3, Rd26), (Ra22, Rb1, Rc3, Rd27), (Ra22, Rb1, Rc3, Rd28), (Ra22, Rb1, Rc3, Rd29), (Ra22, Rb1, Rc4, Rd1), (Ra22, Rb1, Rc4, Rd2), (Ra22, Rb1, Rc4, Rd3), (Ra22, Rb1, Rc4, Rd4), (Ra22, Rb1, Rc4, Rd5), (Ra22, Rb1, Rc4, Rd6), (Ra22, Rb1, Rc4, Rd7), (Ra22, Rb1, Rc4, Rd8), (Ra22, Rb1, Rc4, Rd9), (Ra22, Rb1, Rc4, Rd10), (Ra22, Rb1, Rc4, Rd11), (Ra22, Rb1, Rc4, Rd12), (Ra22, Rb1, Rc4, Rd13), (Ra22, Rb 1, Rc4, Rd14), (Ra22, Rb1, Rc4, Rd15), (Ra22, Rb1, Rc4, Rd16), (Ra22, Rb1, Rc4, Rd17), (Ra22, Rb1, Rc4, Rd18), (Ra22, Rb1, Rc4, Rd19), (Ra22, Rb1, Rc4, Rd20), (Ra22, Rb1, Rc4, Rd21), (Ra22, Rb1, Rc4, Rd22), (Ra22, Rb1, Rc4, Rd23), (Ra22, Rb1, Rc4, Rd24), (Ra22, Rb1, Rc4, Rd25), (Ra22, Rb1, Rc4, Rd26), (Ra22, Rb1, Rc4, Rd27), (Ra22, Rb1, Rc4, Rd28), (Ra22, Rb1, Rc4, Rd29), (Ra22, Rb1, Rc5, Rd1), (Ra22, Rb1, Rc5, Rd2), (Ra22, Rb1, Rc5, Rd3), (Ra22, Rb1, Rc5, Rd4), (Ra22, Rb1, Rc5, Rd5), (Ra22, Rb1, Rc5, Rd6), (Ra22, Rb1, Rc5, Rd7), (Ra22, Rb1, Rc5, Rd8), (Ra22, Rb1, Rc5, Rd9), (Ra22, Rb1, Rc5, Rd10), (Ra22, Rb1, Rc5, Rd11), (Ra22, Rb1, Rc5, Rd12), (Ra22, Rb1, Rc5, Rd13), (Ra22, Rb1, Rc5, Rd14), (Ra22, Rb1, Rc5, Rd15), (Ra22, Rb1, Rc5, Rd16), (Ra22, Rb1, Rc5, Rd17), (Ra22, Rb1, Rc5, Rd18), (Ra22, Rb1, Rc5, Rd19), (Ra22, Rb1, Rc5, Rd20), (Ra22, Rb1 , Rc5, Rd21), (Ra22, Rb1, Rc5, Rd22), (Ra22, Rb1, Rc5, Rd23), (Ra22, Rb1, Rc5, Rd24), (Ra22, Rb1, Rc5, Rd25), (Ra22, Rb1) , Rc5, Rd26), (Ra22, Rb1, Rc5, Rd27), (Ra22, Rb1, Rc5, Rd28), (Ra22, Rb1, Rc5, Rd29), (Ra22, Rb2, Rc1, Rd1), (Ra22, Rb2) , Rc1, Rd2), (Ra22, Rb2, Rc1, Rd3), (Ra22, Rb2, Rc1, Rd5), (Ra22, Rb2, Rc1, Rd6), (Ra22, Rb2) , Rc1, Rd7), (Ra22, Rb2, Rc1, Rd8), (Ra22, Rb2, Rc1, Rd9), (Ra22, Rb2, Rc1, Rd10), (Ra22, Rb2, Rc1, Rd11), (Ra22, Rb2 , Rc1, Rd12), (Ra22, Rb2, Rc1, Rd13), (Ra22, Rb2, Rc1, Rd14), (Ra22, Rb2, Rc1, Rd15), (Ra22, Rb2, Rc1, Rd16), (Ra22, Rb2 , Rc1, Rd17), (Ra22, Rb2, Rc1, Rd18), (Ra22, Rb2, Rc1, Rd19), (Ra22, Rb2, Rc1, Rd20), (Ra22, Rb2, Rc1, Rd21), (Ra22, Rb2 , Rc1, Rd22), (Ra22, Rb2, Rc1, Rd23), (Ra22, Rb2, Rc1, Rd24), (Ra22, Rb2, Rc1, Rd25), (Ra22, Rb2, Rc1, Rd26), (Ra22, Rb2 , Rc1, Rd27), (Ra22, Rb2, Rc1, Rd28), (Ra22, Rb2, Rc1, Rd29), (Ra22, Rb2, Rc2, Rd1), (Ra22, Rb2, Rc2, Rd2), (Ra22, Rb2, Rc2, Rd3), (Ra22, Rb2, Rc2, Rd4), (Ra22, Rb2, Rc2, Rd5), (Ra22, Rb2, Rc2, Rd6), (Ra22, Rb2, Rc2, Rd7), (Ra22, Rb2, Rc2, Rd8), (Ra22, Rb2, Rc2, Rd9), (Ra22, Rb2, Rc2, Rd10), (Ra22, Rb2, Rc2, Rd11), (Ra22, Rb2, Rc2, Rd12), (Ra22, Rb2, Rc2, Rd13), (Ra22, Rb2, Rc2, Rd14), (Ra22, Rb2, Rd2, RaRd15), (Ra22, Rb2, Rc2, Rd17), (Ra22, Rb2, Rc2, Rd18), (Ra22, Rb2, Rc2, Rd19), (Ra22, Rb2, Rc2, Rd20), (Ra22, Rb2, Rc2, Rd21), (Ra22, Rb2, Rc2, Rd22), (Ra22, Rb2, Rc2, Rd23), (Ra22, Rb2, Rc2, Rd24), (Ra22, Rb2, Rc2, Rd25), (Ra22, Rb2, Rc2, Rd26), (Ra22, Rb2, Rc2, Rd27), (Ra22, Rb2, Rc2, Rd28), (Ra22, Rb2, Rc2, Rd29), (Ra22, Rb2, Rc3, Rd1), (Ra22, Rb2, Rc3, Rd2), (Ra22, Rb2, Rc3, Rd3), (Ra22, Rb2, Rc3, Rd4), (Ra22, Rb2, Rc3, Rd5), (Ra22, Rb2, Rc3, Rd6), (Ra22, Rb2, Rc3, Rd7), (Ra22, Rb2, Rc3, Rd8), (Ra22, Rb2, Rc3, Rd9), (Ra22, Rb2, Rc3, Rd10), (Ra22, Rb2, Rc3, Rd11), (Ra22, Rb2, Rc3, Rd12), (Ra22, Rb2, Rc3, Rd13), (Ra22, Rb2, Rc3, Rd14), (Ra22, Rb2, Rc3, Rd15), (Ra22, Rb2, Rc3, Rd16), (Ra22, Rb2, Rc3, Rd17), (Ra22, Rb2, Rc3, Rd18), (Ra22, Rb2, Rc3, Rd19), (Ra22, Rb2, Rc3, Rd20), (Ra22, Rb2, Rc3, Rd21), (Ra22, Rb2, Rc3, Rd22), (Ra22, Rb2, Rc3, Rd23), (Ra22, Rb2, Rc3, Rd24), (Ra22, Rb2, Rc3, Rd25), (Ra22, Rb2, Rc3, Rd26), (Ra22, Rb2, Rc3, Rd27), (Ra22, Rb2, Rc3, Rd28), (Ra22, Rb2, Rc3, Rd29), (Ra22, Rb2, Rc4, Rd1), (Ra22, Rb2, Rc4, Rd2), (Ra22, Rb2, Rc4, Rd3), (Ra22, Rb2, Rc4, Rd4), (Ra22, Rb2, Rc4, Rd5), (Ra22, Rb2, Rc4, Rd6), (Ra22, Rb2, Rc4, Rd7), (Ra22, Rb2, Rc4, Rd8), (Ra22, Rb2, Rc4, Rd9), (Ra22, Rb2, Rc4, Rd10), (Ra22, Rb2, Rc4, Rd11), (Ra22, Rb2, Rc4, Rd12), (Ra22, Rb2, Rc4, Rd1 3), (Ra22, Rb2, Rc4, Rd14), (Ra22, Rb2, Rc4, Rd15), (Ra22, Rb2, Rc4, Rd16), (Ra22, Rb2, Rc4, Rd17), (Ra22, Rb2, Rc4, Rd18),

(Ra22, Rb2, Rc4, Rd19), (Ra22, Rb2, Rc4, Rd20), (Ra22, Rb2, Rc4, Rd21), (Ra22, Rb2, Rc4, Rd22), (Ra22, Rb2, Rc4, Rd23), (Ra22, Rb2, Rc4, Rd24), (Ra22, Rb2, Rc4, Rd25), (Ra22, Rb2, Rc4, Rd26), (Ra22, Rb2, Rc4, Rd27), (Ra22, Rb2, Rc4, Rd28), (Ra22, Rb2, Rc4, Rd29), (Ra22, Rb2, Rc5, Rd1), (Ra22, Rb2, Rc5, Rd2), (Ra22, Rb2, Rc5, Rd3), (Ra22, Rb2, Rc5, Rd4), (Ra22, Rb2, Rc5, Rd5), (Ra22, Rb2, Rc5, Rd6), (Ra22, Rb2, Rc5, Rd7), (Ra22, Rb2, Rc5, Rd8), (Ra22, Rb2, Rc5, Rd9), (Ra22, Rb2, Rc5, Rd10), (Ra22, Rb2, Rc5, Rd11), (Ra22, Rb2, Rc5, Rd12), (Ra22, Rb2, Rc5, Rd13), (Ra22, Rb2, Rc5, Rd14), (Ra22, Rb2, Rc5, Rd15), (Ra22, Rb2, Rc5, Rd16), (Ra22, Rb2, Rc5, Rd17), (Ra22, Rb2, Rc5, Rd18), (Ra22, Rb2, Rc5, Rd19), (Ra22, Rb2, Rc5, Rd20), (Ra22, Rb2, Rc5, Rd21), (Ra22, Rb2, Rc5, Rd22), (Ra22, Rb2, Rc5, Rd23), (Ra22, Rb2, Rc5, Rd24), (Ra22, Rb2, Rc5, Rd25), (Ra22, Rb2, Rc5, Rd26), (Ra22, Rb2, Rc5, Rd27), (Ra22, Rb2, Rc5, Rd28), (Ra22, Rb2, Rc5, Rd29), (Ra23, Rb 1, Rc1, Rd1), (Ra23, Rb1, Rc1, Rd2), (Ra23, Rb1, Rc1, Rd3), (Ra23, Rb1, Rc1, Rd4), (Ra23, Rb1, Rc1, Rd5), (Ra23, Rb1, Rc1, Rd6), (Ra23, Rb1, Rc1, Rd7), (Ra23, Rb1, Rc1, Rd8), (Ra23, Rb1, Rc1, Rd9), (Ra23, Rb1, Rc1, Rd10), (Ra23, Rb1, Rc1, Rd11), (Ra23, Rb1, Rc1, Rd12), (Ra23, Rb1, Rc1, Rd13), (Ra23, Rb1, Rc1, Rd14), (Ra23, Rb1, Rc1, Rd15), (Ra23, Rb1, Rc1, Rd16), (Ra23, Rb1, Rc1, Rd17), (Ra23, Rb1, Rc1, Rd18), (Ra23, Rb1, Rc1, Rd19), (Ra23, Rb1, Rc1, Rd20), (Ra23, Rb1, Rc1, Rd21), (Ra23, Rb1, Rc1, Rd22), (Ra23, Rb1, Rc1, Rd23), (Ra23, Rb1, Rc1, Rd24), (Ra23, Rb1, Rc1, Rd25), (Ra23, Rb1, Rc1, Rd26), (Ra23, Rb1, Rc1, Rd27), (Ra23, Rb1, Rc1, Rd28), (Ra23, Rb1, Rc1, Rd29), (Ra23, Rb1, Rc2, Rd1), (Ra23, Rb1, Rc2, Rd2), (Ra23, Rb1, Rc2, Rd3), (Ra23, Rb1, Rc2, Rd4), (Ra23, Rb1, Rc2, Rd5), (Ra23, Rb1, Rc2, Rd6), (Ra23, Rb1, Rc2, Rd7), (Ra23, Rb1, Rc2, Rd8), (Ra23, Rb1, Rc2, Rd9), (Ra23, Rb1, Rc2, Rd10), (Ra23, Rb1, Rc2, Rd11), (Ra23, Rb1, Rc2, Rd12), (R a23, Rb1, Rc2, Rd13), (Ra23, Rb1, Rc2, Rd14), (Ra23, Rb1, Rc2, Rd15), (Ra23, Rb1, Rc2, Rd16), (Ra23, Rb1, Rc2, Rd17), ( (Ra23, Rb1, Rc2, Rd18), (Ra23, Rb1, Rc2, Rd19), (Ra23, Rb1, Rc2, Rd20), (Ra23, Rb1, Rc2, Rd21), (Ra23, Rb1, Rc2, Rd22), ( (Ra23, Rb1, Rc2, Rd23), (Ra23, Rb1, Rc2, Rd24), (Ra23, Rb1, Rc2, Rd25), (Ra23, Rb1, Rc2, Rd26), (Ra23, Rb1, Rc2, Rd27), ( (Ra23, Rb1, Rc2, Rd28), (Ra23, Rb1, Rc2, Rd29), (Ra23, Rb1, Rc3, Rd1), (Ra23, Rb1, Rc3, Rd2), (Ra23, Rb1, Rc3, Rd3), ( (Ra23, Rb1, Rc3, Rd4), (Ra23, Rb1, Rc3, Rd5), (Ra23, Rb1, Rc3, Rd6), (Ra23, Rb1, Rc3, Rd7), (Ra23, Rb1, Rc3, Rd8), ( (Ra23, Rb1, Rc3, Rd9), (Ra23, Rb1, Rc3, Rd10), (Ra23, Rb1, Rc3, Rd11), (Ra23, Rb1, Rc3, Rd12), (Ra23, Rb1, Rc3, Rd13), ( (Ra23, Rb1, Rc3, Rd14), (Ra23, Rb1, Rc3, Rd15), (Ra23, Rb1, Rc3, Rd16), (Ra23, Rb1, Rc3, Rd17), (Ra23, Rb1, Rc3, Rd18), ( (Ra23, Rb1, Rc3, Rd19), (Ra23, Rb1, Rc3, Rd20), (Ra23, Rb1, Rc3, Rd21), (Ra23, Rb1, Rc3, Rd22), (Ra23, Rb1, Rc3, Rd23), ( Ra23, Rb1, Rc3, Rd24), (Ra23, Rb1, Rc3, Rd25), (Ra23, Rb1, Rc3, Rd26), (Ra23, Rb1, Rc3, Rd27), (Ra23, Rb1, Rc3, Rd28), (Ra23, Rb1, Rc3, Rd29), (Ra23, Rb1, Rc4, Rd1), (Ra23, Rb1, Rc4, Rd2), (Ra23, Rb1, Rc4, Rd3), (Ra23, Rb1, Rc4, Rd4), (Ra23, Rb1, Rc4, Rd5), (Ra23, Rb1, Rc4, Rd6), (Ra23, Rb1, Rc4, Rd7), (Ra23, Rb1, Rc4, Rd8), (Ra23, Rb1, Rc4, Rd9), (Ra23, Rb1, Rc4, Rd10), (Ra23, Rb1, Rc4, Rd11), (Ra23, Rb1, Rc4, Rd12), (Ra23, Rb1, Rc4, Rd13), (Ra23, Rb1, Rc4, Rd14), (Ra23, Rb1, Rc4, Rd15), (Ra23, Rb1, Rc4, Rd16), (Ra23, Rb1, Rc4, Rd17), (Ra23, Rb1, Rc4, Rd18), (Ra23, Rb1, Rc4, Rd19), (Ra23, Rb1, Rc4, Rd20), (Ra23, Rb1, Rc4, Rd21), (Ra23, Rb1, Rc4, Rd22), (Ra23, Rb1, Rc4, Rd23), (Ra23, Rb1, Rc4, Rd24), (Ra23, Rb1, Rc4, Rd25), (Ra23, Rb1, Rc4, Rd26), (Ra23, Rb1, Rc4, Rd27), (Ra23, Rb1, Rc4, Rd28), (Ra23, Rb1, Rc4, Rd29), (Ra23, Rb1, Rc5, Rd1), (Ra23, Rb1, Rc5, Rd2), (Ra23, Rb1, Rc5, Rd3), (Ra23, Rb1, Rc5, Rd4), (Ra23, Rb1, Rc5, Rd5), (Ra23, Rb1, Rc5, Rd6), ( (Ra23, Rb1, Rc5, Rd7), (Ra23, Rb1, Rc5, Rd8), (Ra23, Rb1, Rc5, Rd9), (Ra23, Rb1, Rc5, Rd10), (Ra23, Rb1, Rc5, Rd11), ( (Ra23, Rb1, Rc5, Rd12), (Ra23, Rb1, Rc5, Rd13), (Ra23, Rb1, Rc5, Rd14), (Ra23, Rb1, Rc5, Rd15), (Ra23, Rb1, Rc5, Rd16), ( (Ra23, Rb1, Rc5, Rd17), (Ra23, Rb1, Rc5, Rd18), (Ra23, Rb1, Rc5, Rd19), (Ra23, Rb1, Rc5, Rd20), (Ra23, Rb1, Rc5, Rd21), ( (Ra23, Rb1, Rc5, Rd22), (Ra23, Rb1, Rc5, Rd23), (Ra23, Rb1, Rc5, Rd24), (Ra23, Rb1, Rc5, Rd25), (Ra23, Rb1, Rc5, Rd26), ( (Ra23, Rb1, Rc5, Rd27), (Ra23, Rb1, Rc5, Rd28), (Ra23, Rb1, Rc5, Rd29), (Ra23, Rb2, Rc1, Rd1), (Ra23, Rb2, Rc1, Rd2), ( (Ra23, Rb2, Rc1, Rd3), (Ra23, Rb2, Rc1, Rd4), (Ra23, Rb2, Rc1, Rd5), (Ra23, Rb2, Rc1, Rd6), (Ra23, Rb2, Rc1, Rd7), ( (Ra23, Rb2, Rc1, Rd8), (Ra23, Rb2, Rc1, Rd9), (Ra23, Rb2, Rc1, Rd10), (Ra23, Rb2, Rc1, Rd11), (Ra23, Rb2, Rc1, Rd12), ( (Ra23, Rb2, Rc1, Rd13), (Ra23, Rb2, Rc1, Rd14), (Ra23, Rb2, Rc1, Rd15), (Ra23, Rb2, Rc1, Rd16), (Ra23, Rb2, Rc1, Rd17), ( Ra23, Rb2, R c1, Rd18), (Ra23, Rb2, Rc1, Rd19), (Ra23, Rb2, Rc1, Rd20), (Ra23, Rb2, Rc1, Rd21), (Ra23, Rb2, Rc1, Rd22), (Ra23, Rb2, Rc1, Rd23), (Ra23, Rb2, Rc1, Rd24), (Ra23, Rb2, Rc1, Rd25), (Ra23, Rb2, Rc1, Rd26), (Ra23, Rb2, Rc1, Rd27), (Ra23, Rb2, Rc1, Rd28), (Ra23, Rb2, Rc1, Rd29), (Ra23, Rb2, Rc2, Rd1), (Ra23, Rb2, Rc2, Rd2), (Ra23, Rb2, Rc2, Rd3), (Ra23, Rb2, Rc2, Rd4), (Ra23, Rb2, Rc2, Rd5), (Ra23, Rb2, Rc2, Rd6), (Ra23, Rb2, Rc2, Rd7), (Ra23, Rb2, Rc2, Rd8), (Ra23, Rb2, Rc2, Rd9), (Ra23, Rb2, Rc2, Rd10), (Ra23, Rb2, Rc2, Rd11), (Ra23, Rb2, Rc2, Rd12), (Ra23, Rb2, Rc2, Rd13), (Ra23, Rb2, Rc2, Rd14), (Ra23, Rb2, Rc2, Rd15), (Ra23, Rb2, Rc2, Rd16), (Ra23, Rb2, Rc2, Rd17), (Ra23, Rb2, Rc2, Rd18), (Ra23, Rb2, Rc2, Rd19), (Ra23, Rb2, Rc2, Rd20), (Ra23, Rb2, Rc2, Rd21), (Ra23, Rb2, Rc2, Rd22), (Ra23, Rb2, Rc2, Rd23), (Ra23, Rb2, Rc2, Rd24), (Ra23, Rb2, Rc2, Rd25), (Ra23, Rb2, Rc2, Rd26), (Ra23, Rb2, Rc2, Rd27), (Ra23, Rb2, Rc2, Rd28), (Ra23, Rb2, Rc2, Rd29) , (Ra23, Rb2, Rc3, Rd1), (Ra23, Rb2, Rc3, Rd2), (Ra23, Rb2, Rc3, Rd3), (Ra23, Rb2, Rc3, Rd4), (Ra23, Rb2, Rc3, Rd5) , (Ra23, Rb2, Rc3, Rd6), (Ra23, Rb2, Rc3, Rd7), (Ra23, Rb2, Rc3, Rd8), (Ra23, Rb2, Rc3, Rd9), (Ra23, Rb2, Rc3, Rd10) , (Ra23, Rb2, Rc3, Rd11), (Ra23, Rb2, Rc3, Rd12), (Ra23, Rb2, Rc3, Rd13), (Ra23, Rb2, Rc3, Rd14), (Ra23, Rb2, Rc3, Rd15) , (Ra23, Rb2, Rc3, Rd16), (Ra23, Rb2, Rc3, Rd17), (Ra23, Rb2, Rc3, Rd18), (Ra23, Rb2, Rc3, Rd19), (Ra23, Rb2, Rc3, Rd20) , (Ra23, Rb2, Rc3, Rd21), (Ra23, Rb2, Rc3, Rd22), (Ra23, Rb2, Rc3, Rd23), (Ra23, Rb2, Rc3, Rd24), (Ra23, Rb2, Rc3, Rd25) , (Ra23, Rb2, Rc3, Rd26), (Ra23, Rb2, Rc3, Rd27), (Ra23, Rb2, Rc3, Rd28), (Ra23, Rb2, Rc3, Rd29), (Ra23, Rb2, Rc4, Rd1) , (Ra23, Rb2, Rc4, Rd2), (Ra23, Rb2, Rc4, Rd3), (Ra23, Rb2, Rc4, Rd4), (Ra23, Rb2, Rc4, Rd5), (Ra23, Rb2, Rc4, Rd6) , (Ra23, Rb2, Rc4, Rd7), (Ra23, Rb2, Rc4, Rd8), (Ra23, Rb2, Rc4, Rd9), (Ra23, Rb2, Rc4, Rd10), (Ra23, Rb2, Rc4, Rd11) , (Ra23, Rb2, Rc4 , Rd12), (Ra23, Rb2, Rc4, Rd13), (Ra23, Rb2, Rc4, Rd14), (Ra23, Rb2, Rc4, Rd15), (Ra23, Rb2, Rc4, Rd16), (Ra23, Rb2, Rc4 , Rd17), (Ra23, Rb2, Rc4, Rd18), (Ra23, Rb2, Rc4, Rd19), (Ra23, Rb2, Rc4, Rd20), (Ra23, Rb2, Rc4, Rd21), (Ra23, Rb2, Rc4) , Rd22), (Ra23, Rb2, Rc4, Rd23), (Ra23, Rb2, Rc4, Rd24), (Ra23, Rb2, Rc4, Rd25), (Ra23, Rb2, Rc4, Rd26), (Ra23, Rb2, Rc4 , Rd27), (Ra23, Rb2, Rc4, Rd28), (Ra23, Rb2, Rc4, Rd29), (Ra23, Rb2, Rc5, Rd1), (Ra23, Rb2, Rc5, Rd2), (Ra23, Rb2, Rc5) , Rd3), (Ra23, Rb2, Rc5, Rd4), (Ra23, Rb2, Rc5, Rd5), (Ra23, Rb2, Rc5, Rd6), (Ra23, Rb2, Rc5, Rd7), (Ra23, Rb2, Rc5) , Rd8), (Ra23, Rb2, Rc5, Rd9), (Ra23, Rb2, Rc5, Rd10), (Ra23, Rb2, Rc5, Rd11), (Ra23, Rb2, Rc5, Rd12), (Ra23, Rb2, Rc5) , Rd13), (Ra23, Rb2, Rc5, Rd14), (Ra23, Rb2, Rc5, Rd15), (Ra23, Rb2, Rc5, Rd16), (Ra23, Rb2, Rc5, Rd17), (Ra23, Rb2, Rc5) , Rd18), (Ra23, Rb2, Rc5, Rd19), (Ra23, Rb2, Rc5, Rd20), (Ra23, Rb2, Rc5, Rd21), (Ra23, Rb2, Rc5, Rd22), (Ra23, Rb2, Rc5) , Rd23) (Ra23, Rb2, Rc5, Rd24), (Ra23, Rb2, Rc5, Rd25), (Ra23, Rb2, Rc5, Rd26), (Ra23, Rb2, Rc5, Rd27), (Ra23, Rb2, Rc5, Rd28), (Ra23, Rb2, Rc5, Rd29), (Ra24, Rb1, Rc1, Rd1), (Ra24, Rb1, Rc1, Rd2), (Ra24, Rb1, Rc1, Rd3), (Ra24, Rb1, Rc1, Rd4), (Ra24, Rb1, Rc1, Rd5), (Ra24, Rb1, Rc1, Rd6), (Ra24, Rb1, Rc1, Rd7), (Ra24, Rb1, Rc1, Rd8), (Ra24, Rb1, Rc1, Rd9), (Ra24, Rb1, Rc1, Rd10), (Ra24, Rb1, Rc1, Rd11), (Ra24, Rb1, Rc1, Rd12), (Ra24, Rb1, Rc1, Rd13), (Ra24, Rb1, Rc1, Rd14), (Ra24, Rb1, Rc1, Rd15), (Ra24, Rb1, Rc1, Rd16), (Ra24, Rb1, Rc1, Rd17), (Ra24, Rb1, Rc1, Rd18), (Ra24, Rb1, Rc1, Rd19), (Ra24, Rb1, Rc1, Rd20), (Ra24, Rb1, Rc1, Rd21), (Ra24, Rb1, Rc1, Rd22), (Ra24, Rb1, Rc1, Rd23), (Ra24, Rb1, Rc1, Rd24), (Ra24, Rb1, Rc1, Rd25), (Ra24, Rb1, Rc1, Rd26), (Ra24, Rb1, Rc1, Rd27), (Ra24, Rb1, Rc1, Rd28), (Ra24, Rb1, Rc1, Rd29), (Ra24, Rb1, Rc2, Rd1), (Ra24, Rb1, Rc2, Rd2), (Ra24, Rb1, Rc2, Rd3), (Ra24, Rb1, Rc2, Rd4), (Ra24, Rb1, Rc2, Rd5), (Ra24, Rb1, R c2, Rd6), (Ra24, Rb1, Rc2, Rd7), (Ra24, Rb1, Rc2, Rd8), (Ra24, Rb1, Rc2, Rd9), (Ra24, Rb1, Rc2, Rd10), (Ra24, Rb1, Rc2, Rd11), (Ra24, Rb1, Rc2, Rd12), (Ra24, Rb1, Rc2, Rd13), (Ra24, Rb1, Rc2, Rd14), (Ra24, Rb1, Rc2, Rd15), (Ra24, Rb1, Rc2, Rd16), (Ra24, Rb1, Rc2, Rd17), (Ra24, Rb1, Rc2, Rd18), (Ra24, Rb1, Rc2, Rd19), (Ra24, Rb1, Rc2, Rd20), (Ra24, Rb1, Rc2, Rd21), (Ra24, Rb1, Rc2, Rd22), (Ra24, Rb1, Rc2, Rd23), (Ra24, Rb1, Rc2, Rd24), (Ra24, Rb1, Rc2, Rd25), (Ra24, Rb1, Rc2, Rd26), (Ra24, Rb1, Rc2, Rd27), (Ra24, Rb1, Rc2, Rd28), (Ra24, Rb1, Rc2, Rd29), (Ra24, Rb1, Rc3, Rd1), (Ra24, Rb1, Rc3, Rd2), (Ra24, Rb1, Rc3, Rd3), (Ra24, Rb1, Rc3, Rd4), (Ra24, Rb1, Rc3, Rd5), (Ra24, Rb1, Rc3, Rd6), (Ra24, Rb1, Rc3, Rd7), (Ra24, Rb1, Rc3, Rd8), (Ra24, Rb1, Rc3, Rd9), (Ra24, Rb1, Rc3, Rd10), (Ra24, Rb1, Rc3, Rd11), (Ra24, Rb1, Rc3, Rd12), (Ra24, Rb1, Rc3, Rd13), (Ra24, Rb1, Rc3, Rd14), (Ra24, Rb1, Rc3, Rd15), (Ra24, Rb1, Rc3, Rd16), (Ra24, Rb1, Rc3, Rd17), ( (Ra24, Rb1, Rc3, Rd18), (Ra24, Rb1, Rc3, Rd19), (Ra24, Rb1, Rc3, Rd20), (Ra24, Rb1, Rc3, Rd21), (Ra24, Rb1, Rc3, Rd22), ( (Ra24, Rb1, Rc3, Rd23), (Ra24, Rb1, Rc3, Rd24), (Ra24, Rb1, Rc3, Rd25), (Ra24, Rb1, Rc3, Rd26), (Ra24, Rb1, Rc3, Rd27), ( (Ra24, Rb1, Rc3, Rd28), (Ra24, Rb1, Rc3, Rd29), (Ra24, Rb1, Rc4, Rd1), (Ra24, Rb1, Rc4, Rd2), (Ra24, Rb1, Rc4, Rd3), ( (Ra24, Rb1, Rc4, Rd4), (Ra24, Rb1, Rc4, Rd5), (Ra24, Rb1, Rc4, Rd6), (Ra24, Rb1, Rc4, Rd7), (Ra24, Rb1, Rc4, Rd8), ( (Ra24, Rb1, Rc4, Rd9), (Ra24, Rb1, Rc4, Rd10), (Ra24, Rb1, Rc4, Rd11), (Ra24, Rb1, Rc4, Rd12), (Ra24, Rb1, Rc4, Rd13), ( Ra24, Rb1, Rc4, Rd14), (Ra24, Rb1, Rc4, Rd15), (Ra24,
Rb1, Rc4, Rd16), (Ra24, Rb1, Rc4, Rd17), (Ra24, Rb1, Rc4, Rd18), (Ra24, Rb1, Rc4, Rd19), (Ra24, Rb1, Rc4, Rd20), (Ra24, Rb1, Rc4, Rd21), (Ra24, Rb1, Rc4, Rd22), (Ra24, Rb1, Rc4, Rd23), (Ra24, Rb1, Rc4, Rd24), (Ra24, Rb1, Rc4, Rd25), (Ra24, Rb1, Rc4, Rd26), (Ra24, Rb1, Rc4, Rd27), (Ra24, Rb1, Rc4, Rd28), (Ra24, Rb1, Rc4, Rd29), (Ra24, Rb1, Rc5, Rd1), (Ra24, Rb1, Rc5, Rd2), (Ra24, Rb1, Rc5, Rd3), (Ra24, Rb1, Rc5, Rd4), (Ra24, Rb1, Rc5, Rd5), (Ra24, Rb1, Rc5, Rd6), (Ra24, Rb1, Rc5, Rd7), (Ra24, Rb1, Rc5, Rd8), (Ra24, Rb1, Rc5, Rd9), (Ra24, Rb1, Rc5, Rd10), (Ra24, Rb1, Rc5, Rd11), (Ra24, Rb1, Rc5, Rd12), (Ra24, Rb1, Rc5, Rd13), (Ra24, Rb1, Rc5, Rd14), (Ra24, Rb1, Rc5, Rd15), (Ra24, Rb1, Rc5, Rd16), (Ra24, Rb1, Rc5, Rd17), (Ra24, Rb1, Rc5, Rd18), (Ra24, Rb1, Rc5, Rd19), (Ra24, Rb1, Rc5, Rd20), (Ra24, Rb1, Rc5, Rd21), (Ra24, Rb1, Rc5, Rd22), (Ra24, Rb1, Rc5, Rd23), (Ra24, Rb1, Rc5, Rd24), (Ra24, Rb1, Rc5, Rd25), (Ra24, Rb1, Rc5, Rd26), (Ra24, Rb1, Rc5, Rd27), (Ra24, Rb1, Rc5, Rd28), (Ra24, Rb1, Rc5, Rd29), (Ra24, Rb2, Rc1, Rd1), (Ra24, Rb2, Rc1, Rd2), (Ra24, Rb2, Rc1, Rd3), (Ra24, Rb2, Rc1, Rd4), (Ra24, Rb2, Rc1, Rd5), (Ra24, Rb2, Rc1, Rd6), (Ra24, Rb2, Rc1, Rd7), (Ra24, Rb2, Rc1, Rd8), (Ra24, Rb2, Rc1, Rd9), (Ra24, Rb2, Rc1, Rd10), (Ra24, Rb2, Rc1, Rd11), (Ra24, Rb2, Rc1, Rd12), (Ra24, Rb2, Rc1, Rd13), (Ra24, Rb2, Rc1, Rd14), (Ra24, Rb2, Rc1, Rd15), (Ra24, Rb2, Rc1, Rd16), (Ra24, Rb2, Rc1, Rd17), (Ra24, Rb2, Rc1, Rd18), (Ra24, Rb2, Rc1, Rd19), (Ra24, Rb2, Rc1, Rd20), (Ra24, Rb2, Rc1, Rd21), (Ra24, Rb2, Rc1, Rd22), (Ra24, Rb2, Rc1, Rd23), (Ra24, Rb2, Rc1, Rd24), (Ra24, Rb2, Rc1, Rd25), (Ra24, Rb2, Rc1, Rd26), (Ra24, Rb2, Rc1, Rd27), (Ra24, Rb2, Rc1, Rd28), (Ra24, Rb2, Rc1, Rd29), (Ra24, Rb2, Rc2, Rd1), (Ra24, Rb2, Rc2, Rd2), (Ra24, Rb2, Rc2, Rd3), (Ra24, Rb2, Rc2, Rd4), (Ra24, Rb2, Rc2, Rd5),

(Ra24, Rb2, Rc2, Rd6), (Ra24, Rb2, Rc2, Rd7), (Ra24, Rb2, Rc2, Rd8), (Ra24, Rb2, Rc2, Rd9), (Ra24, Rb2, Rc2, Rd10), (Ra24, Rb2, Rc2, Rd11), (Ra24, Rb2, Rc2, Rd13), (Ra24, Rb2, Rc2, Rd14), (Ra24, Rb2, Rc2, Rd15), (Ra24, Rb2, Rc2, Rd16), (Ra24, Rb2, Rc2, Rd18), (Ra24, Rb2, Rc2, Rd19), (Ra24, Rb2, Rc2, Rd20), (Ra24, Rb2, Rc2, Rd21), (Ra24, Rb2, Rc2, Rd23), (Ra24, Rb2, Rc2, Rd24), (Ra24, Rb2, Rc2, Rd25), (Ra24, Rb2, Rc2, Rd26), (Ra24, Rb2, Rc2, (Rd27), (Ra24, Rb2, Rc2, Rd28), (Ra24, Rb2, Rc2, Rd29), (Ra24, Rb2, Rc3, Rd1), (Ra24, Rb2, Rc3, Rd2), (Ra24, Rb2, Rc3, Rd3), (Ra24, Rb2, Rc3, Rd4), (Ra24, Rb2, Rc3, Rd5), (Ra24, Rb2, Rc3, Rd6), (Ra24, Rb2, Rc3, Rd7), (Ra24, Rb2, Rc3, Rd8), (Ra24, Rb2,24Rc3, bRd9), (Ra24, Rb2, Rc3, Rd10), (Ra24, Rb2, Rc3, Rd11), (Ra24, Rb2, Rc3, Rd12), (Ra 24, Rb2, Rc3, Rd13), (Ra24, Rb2, Rc3, Rd14), (Ra24, Rb2, Rc3, Rd15), (Ra24, Rb2, Rc3, Rd16), (Ra24, Rb2, Rc3, Rd17), (Ra24, Rb2, 3Rc3, Rd18), (Ra24, Rb2, Rc3, Rd19), (Ra24, Rb2, Rc3, Rd20), (Ra24, Rb2, Rc3, Rd21), (Ra24, Rb2, Rc3, Rd22), (Ra24, Rb2, Rc3, Rd23), (Ra24, Rb2, Rc3, (Rd24), (Ra24, Rb2, Rc3, Rd25), (Ra24, Rb2, Rc3, Rd26), (Ra24, Rb2, Rc3, Rd27), (Ra24, Rb2, Rc3, Rd28), (Ra24, Rb2, Rc3, Rd29), (Ra24, Rb2, Rc4, Rd1), (Ra24, Rb2, Rc4, Rd2), (Ra24, Rb2, Rc4, Rd3), (Ra24, Rb2, Rc4, Rd4), (Ra24, Rb2, Rc4, Rd5), (Ra24, Rb2, Rc4, Rd6), (Ra24, Rb2, Rc4, Rd7), (Ra24, Rb2, Rc4, Rd8), (Ra24, Rb2, Rc4, Rd9), (Ra24, Rb2, Rc4, Rd10), (Ra24, Rb2, Rc4, Rd11), (Ra24, Rb2, Rc4, Rd12), (Ra24, Rb2, Rc4, Rd13), Ra24, Rb2, Rc4, Rd14), (Ra24, Rb2, Rc4, 、 Rd15), (Ra24, Rb2, Rc4, Rd16), (Ra24, Rb2, Rc4, Rd17), (Ra24, Rb2, Rc4, Rd18), Ra24, Rb2, Rc4, Rd19), (Ra2 4, Rb2, Rc4, Rd20), (Ra24, Rb2, Rc4, Rd21), (Ra24, Rb2, Rc4, Rd22), (Ra24, Rb2, Rc4, Rd23), (Ra24, Rb2, Rc4, Rd24), Ra24, Rb2, Rc4, Rd25), (Ra24, Rb2, Rc4, Rd26), (Ra24, Rb2, Rc4, Rd27), (Ra24, Rb2, Rc4, Rd28), (Ra24, Rb2, Rc4, Rd29), Ra24, Rb2, Rc5, 1Rd1), (Ra24, Rb2, Rc5, 、 Rd2), (Ra24, cRb2, Rc5, Rd3), (Ra24, Rb2, Rc5, Rd4), (Ra24, Rb2, Rc5, Rd5), (Ra24, Rb2, Rc5, Rd6), (Ra24, Rb2, Rc5, Rd7), (Ra24, Rb2, Rc5, Rd8), (Ra24, Rb2, Rc5, Rd9), (Ra24, Rb2, Rc5, Rd10), Ra24, Rb2, Rc5, 11Rd11), (Ra24, Rb2, Rc5, Rd12), (Ra24, Rb2, Rc5, Rd13), (Ra24, Rb2, Rc5, Rd14), (Ra24, Rb2, Rc5, Rd15), (Ra24, Rb2, 5Rc5, Rd16), (Ra24, Rb2, Rc5, Rd17), (Ra24, Rb2, Rc5, Rd18), (Ra24, Rb2, Rc5, Rd19), (Ra24, Rb2, Rc5, Rd20), Ra24, Rb2, Rc5, Rd21), (Ra24, Rb2, Rc5, (Rd22), (Ra24, 5Rb2, Rc5, Rd23), (Ra24, Rb2, Rc5, Rd24), (Ra24, Rb2, Rc5, Rd25), Ra24, Rb2, Rc5, Rd26), (Ra24 , Rb2, Rc5, Rd27), (Ra24, Rb2, Rc5, Rd28), (Ra24, Rb2, Rc5, Rd29), (Ra25, Rb1, Rc1, Rd1), (Ra25, Rb1, Rc1, Rd2), (Ra25 , Rb1, Rc1, Rd3), (Ra25, Rb1, Rc1, (Rd4), (Ra25, Rb1, Rc1, Rd5), (Ra25, Rb1, Rc1, Rd6), (Ra25, Rb1, Rc1, Rd7), (Ra25 , Rb1, Rc1, Rd8), (Ra25, Rb1, Rc1, Rd9), (Ra25, Rb1, Rc1, Rd10), (Ra25, Rb1, Rc1, Rd11), (Ra25, Rb1, Rc1, Rd12), (Ra25 , Rb1, Rc1, Rd13), (Ra25, Rb1, Rc1, (Rd14), (Ra25, Rb1, Rc1, Rd15), (Ra25, Rb1, Rc1, Rd16), (Ra25, Rb1, Rc1, Rd17), (Ra25 , Rb1, Rc1, Rd18), (Ra25, Rb1, Rc1, (Rd19), (Ra25, Rb1, Rc1, Rd20), (Ra25, Rb1, Rc1, Rd21), (Ra25, Rb1, Rc1, Rd22), (Ra25 , Rb1, Rc1, Rd23), (Ra25, Rb1, Rc1, Rd24), (Ra25, Rb1, Rc1, Rd25), (Ra25, Rb1, Rc1, Rd26), (Ra25, Rb1, Rc1, Rd27), (Ra25 , Rb1, Rc1, Rd28), (Ra25, Rb1, Rc1, Rd29), (Ra25, Rb1, Rc2, Rd1), (Ra25, Rb1, Rc2, Rd2), (Ra25, Rb1, Rc2, Rd3), (Ra25 , Rb1, Rc2, Rd4), (Ra25, Rb 1, Rc2, Rd5), (Ra25, Rb1, Rc2, Rd6), (Ra25, Rb1, Rc2, Rd7), (Ra25, Rb1, Rc2, Rd8), (Ra25, Rb1, Rc2, Rd9), (Ra25, Rb1, Rc2, Rd10), (Ra25, Rb1, Rc2, Rd11), (Ra25, Rb1, Rc2, Rd13), (Ra25, Rb1, Rc2, Rd13), (Ra25, Rb1, Rc2, Rd14), (Ra25, Rb1, Rc2, Rd15), (Ra25, Rb1, Rc2, Rd16), (Ra25, Rb1, Rc2, Rd17), (Ra25, Rb1, Rc2, Rd18), (Ra25, Rb1, Rc2, Rd19), (Ra25, Rb1, Rc2, Rd20), (Ra25, Rb1, Rc2, Rd21), (Ra25, Rb1, Rc2, Rd22), (Ra25, Rb1, Rc2, Rd23), (Ra25, Rb1, Rc2, Rd24), (Ra25, Rb1, Rc2, Rd25), (Ra25, Rb1, Rc2, Rd26), (Ra25, Rb1, Rc2, Rd27), (Ra25, Rb1, Rc2, Rd28), (Ra25, Rb1, Rc2, Rd29), (Ra25, Rb1, Rc3, Rd1), (Ra25, Rb1, Rc3, Rd2), (Ra25, Rb1, Rc3, Rd3), (Ra25, Rb1, Rc3, Rd4), (Ra25, Rb1, Rc3, Rd5), (Ra25, Rb1, Rc3, Rd6), (Ra25, Rb1, Rc3, Rd7), (Ra25, Rb1, Rc3, Rd8), (Ra25, Rb1, Rc3, Rd9), (Ra25, Rb1, Rc3, Rd10), (Ra25, Rb1, Rc3, Rd11), (Ra25, Rb1, Rc 3, Rd12), (Ra25, Rb1, Rc3, Rd13), (Ra25, Rb1, Rc3, Rd15), (Ra25, Rb1, Rc3, Rd16), (Ra25, Rb1, Rc3, Rd17), (Ra25, Rb1, Rc3, Rd18), (Ra25, Rb1, Rc3, Rd19), (Ra25, Rb1, Rc3, Rd20), (Ra25, Rb1, Rc3, Rd21), (Ra25, Rb1, Rc3, Rd22), (Ra25, Rb1, Rc3, Rd23), (Ra25, Rb1, Rc3, Rd24), (Ra25, Rb1, Rc3, Rd25), (Ra25, Rb1, Rc3, Rd26), (Ra25, Rb1, Rc3, Rd27), (Ra25, Rb1, Rc3, Rd28), (Ra25, Rb1, Rc3, Rd29), (Ra25, Rb1, Rc4, Rd1), (Ra25, Rb1, Rc4, Rd2), (Ra25, Rb1, Rc4, Rd3), (Ra25, Rb1, Rd4), (Ra25, Rb1, Rc4, Rd6), (Ra25, Rb1, Rc4, Rd7), (Ra25, Rb1, Rc4, Rd8), (Ra25, Rb1, Rc4, Rd9), (Ra25, Rb1, Rc4, Rd10), (Ra25, Rb1, Rc4, Rd11), (Ra25, Rb1, Rc4, Rd12), (Ra25, Rb1, Rc4, Rd13), (Ra25, Rb1, Rc4, Rd15), (Ra25, Rb1, Rc4, Rd16), (Ra25, Rb1, Rc4, Rd17), (Ra25, Rb1, Rc4, Rd18), (Ra25, Rb1, Rc4 , Rd19), (Ra25, Rb1, Rc4, Rd20), (Ra25, Rb1, Rc4, Rd22), (Ra25, Rb1, Rc4, Rd23), (Ra25, Rb1, Rc4) , Rd24), (Ra25, Rb1, Rc4, Rd26), (Ra25, Rb1, Rc4, Rd27), (Ra25, Rb1, Rc4, Rd28), (Ra25, Rb1, Rc4) , Rd29), (Ra25, Rb1, Rc5, Rd1), (Ra25, Rb1, Rc5, Rd3), (Ra25, Rb1, Rc5, Rd4), (Ra25, Rb1, Rc5) , Rd5), (Ra25, Rb1, Rc5, Rd6), (Ra25, Rb1, Rc5, Rd8), (Ra25, Rb1, Rc5, Rd9), (Ra25, Rb1, Rc5) , Rd10), (Ra25, Rb1, Rc5, Rd11), (Ra25, Rb1, Rc5, Rd13), (Ra25, Rb1, Rc5, Rd14), (Ra25, Rb1, Rc5) , Rd15), (Ra25, Rb1, Rc5, Rd16), (Ra25, Rb1, Rc5, Rd18), (Ra25, Rb1, Rc5, Rd19), (Ra25, Rb1, Rc5) , Rd20), (Ra25, Rb1, Rc5, Rd21), (Ra25, Rb1, Rc5, Rd23), (Ra25, Rb1, Rc5, Rd24), (Ra25, Rb1, Rc5) , Rd25), (Ra25, Rb1, Rc5, Rd26), (Ra25, Rb1, Rc5, Rd27), (Ra25, Rb1, Rc5, Rd28), (Ra25, Rb1, Rc5, Rd29), (Ra25, Rb2, Rc1, Rd1), (Ra25, Rb2, Rc1, Rd2), (Ra25, Rb2, Rc1, Rd3), (Ra25, Rb2, Rc1, Rd4), (Ra25, Rb2, Rc1, Rd5), (Ra25, Rb2, Rc1, Rd6), (Ra25, Rb2, Rc1, Rd7), (Ra25, Rb2, Rc1, Rd8), (Ra25, Rb2, Rc1, Rd9), (Ra25, Rb2, Rc1, Rd10), (Ra25, Rb2, Rc1, Rd11), (Ra25, Rb2, Rc1, Rd12), (Ra25, Rb2, Rc1, Rd13), (Ra25, Rb2, Rc1, Rd14), (Ra25, Rb2, Rc1, Rd15), (Ra25, Rb2, Rc1, Rd16), (Ra25, Rb2, Rc1, Rd17), (Ra25, Rb2, Rc1, Rd18), (Ra25, Rb2, Rc1, Rd19), (Ra25, Rb2, Rc1, Rd20), (Ra25, Rb2, Rc1, Rd21), (Ra25, Rb2, Rc1, Rd22), (Ra25, Rb2, Rc1, Rd23), (Ra25, Rb2, Rc1, Rd24), (Ra25, Rb2, Rc1, Rd25), (Ra25, Rb2, Rc1, Rd26), (Ra25, Rb2, Rc1, Rd27), (Ra25, Rb2, Rc1, Rd28), (Ra25, Rb2, Rc1, Rd29), (Ra25, Rb2, Rc2, Rd1), (Ra25, Rb2, Rc2, Rd2), (Ra25, Rb2, Rc2, Rd3), (Ra25, Rb2, Rc2, Rd 4), (Ra25, Rb2, Rc2, Rd5), (Ra25, Rb2, Rc2, Rd6), (Ra25, Rb2, Rc2, Rd7), (Ra25, Rb2, Rc2, Rd8), (Ra25, Rb2, Rc2, Rd9), (Ra25, Rb2, Rc2, Rd10), (Ra25, Rb2, Rc2, Rd11), (Ra25, Rb2, Rc2, Rd12), (Ra25, Rb2, Rc2, Rd13), (Ra25, Rb2, Rc2, Rd14), (Ra25, Rb2, Rc2, Rd15), (Ra25, Rb2, Rc2, Rd16), (Ra25, Rb2, Rc2, Rd17), (Ra25, Rb2, Rc2, Rd18), (Ra25, Rb2, Rc2, Rd19), (Ra25, Rb2, Rc2, Rd20), (Ra25, Rb2, Rc2, Rd21), (Ra25, Rb2, Rc2, Rd22), (Ra25, Rb2, Rc2, Rd23), (Ra25, Rb2, Rc2, Rd24), (Ra25, Rb2, Rc2, Rd25), (Ra25, Rb2, Rc2, Rd26), (Ra25, Rb2, Rc2, Rd27), (Ra25, Rb2, Rc2, Rd28), (Ra25, Rb2, Rc2, Rd29), (Ra25, Rb2, Rc3, Rd1), (Ra25, Rb2, Rc3, Rd2), (Ra25, Rb2, Rc3, Rd3), (Ra25, Rb2, Rc3, Rd4), (Ra25, Rb2, Rc3, Rd5), (Ra25, Rb2, Rc3, Rd6), (Ra25, Rb2, Rc3, Rd7), (Ra25, Rb2, Rc3, Rd8), (Ra25, Rb2, Rc3, Rd9), (Ra25, Rb2, Rc3, Rd10), (Ra25, Rb2, Rc3, Rd11), ( (Ra25, Rb2, Rc3, Rd12), (Ra25, Rb2, Rc3, Rd13), (Ra25, Rb2, Rc3, Rd14), (Ra25, Rb2, Rc3, Rd15), (Ra25, Rb2, Rc3, Rd16), Ra25, Rb2, Rc3, 17Rd17), (Ra25, Rb2, Rc3, Rd18), (Ra25, Rb2, Rc3, Rd19), (Ra25, Rb2, Rc3, Rd20), (Ra25, Rb2, Rc3, Rd21), (Ra25, Rb2, Rc3, Rd22), (Ra25, Rb2, Rc3, Rd23), (Ra25, Rb2, Rc3, Rd24), (Ra25, Rb2, Rc3, Rd25), (Ra25, Rb2, Rc3, Rd26), (Ra25, Rb2, Rc3, Rd27), (Ra25, Rb2, Rc3, Rd28), (Ra25, Rb2, Rc3, Rd29), (Ra25, Rb2, Rc4, Rd1), (Ra25, Rb2, Rc4, Rd2), (Ra25, Rb2, Rc4, Rd3), (Ra25, Rb2, Rc4, Rd4), (Ra25, Rb2, Rc4, Rd5), (Ra25, Rb2, Rc4, Rd6), (Ra25, Rb2, Rc4, Rd7), (Ra25, Rb2, Rc4, Rd8), (Ra25, Rb2, Rc4, Rd9), (Ra25, Rb2, Rc4, Rd10), (Ra25, Rb2, Rc4, Rd11), (Ra25, Rb2, Rc4, Rd12), Ra25, Rb2, Rc4, 13Rd13), (Ra25, Rb2, Rc4, 、 Rd14), (Ra25, Rb2, Rc4, Rd15), (Ra25, Rb2, Rc4, Rd16), (Ra25, Rb2, Rc4, Rd17), Ra25, Rb2, Rc4, Rd18), (R a25, Rb2, Rc4, Rd19), (Ra25, Rb2, Rc4, Rd20), (Ra25, Rb2, Rc4, Rd21), (Ra25, Rb2, Rc4, Rd22), (Ra25, Rb2, Rc4, Rd23), (Ra25, Rb2, Rc4, 24Rd24), (Ra25, Rb2, Rc4, Rd25), (Ra25, Rb2, Rc4, Rd26), (Ra25, Rb2, Rc4, Rd27), (Ra25, Rb2, Rc4, Rd28), Ra25, Rb2, Rc4, 29Rd29), (Ra25, Rb2, Rc5, Rd1), (Ra25, Rb2, Rc5, Rd2), (Ra25, Rb2, Rc5, Rd3), (Ra25, Rb2, Rc5, Rd4), (Ra25, Rb2, Rc5, Rd5), (Ra25, Rb2, Rc5, Rd6), (Ra25, Rb2, Rc5, Rd7), (Ra25, Rb2, (Rc5, Rd8), (Ra25, Rb2, Rc5, Rd9), Ra25, Rb2, Rc5, Rd10), (Ra25, Rb2, Rc5, Rd11), (Ra25, Rb2, Rc5, Rd12), (Ra25, Rb2, Rc5, Rd13), (Ra25, Rb2, Rc5, Rd14), Ra25, Rb2, Rc5, 15Rd15), (Ra25, Rb2, Rc5, Rd16), (Ra25, Rb2, Rc5, Rd17), (Ra25, Rb2, Rc5, Rd18), (Ra25, Rb2, Rc5, Rd19), Ra25, Rb2, Rc5, 20Rd20), (Ra25, Rb2, Rc5, Rd21), (Ra25, Rb2, Rc5, Rd22), (Ra25, Rb2, Rc5, Rd23), (Ra25, Rb2, Rc5, Rd24), Ra25, Rb2, Rc5, Rd25), (Ra 25, Rb2, Rc5, Rd26), (Ra25, Rb2, Rc5, (Rd27), (Ra25, Rb2, Rc5, Rd28), (Ra25, Rb2, Rc5, Rd29), (Ra26, Rb1, Rc1, Rd1), Ra26, Rb1, Rc1, Rd2), (Ra26, Rb1, Rc1, Rd3), (Ra26, Rb1, Rc1, Rd4),

(Ra26, Rb1, Rc1, Rd5), (Ra26, Rb1, Rc1, Rd7), (Ra26, Rb1, Rc1, Rd8), (Ra26, Rb1, Rc1, Rd9), (Ra26, Rb1, Rc1, Rd10), (Ra26, Rb1, Rc1, Rd11), (Ra26, Rb1, Rc1, Rd12), (Ra26, Rb1, Rc1, Rd13), (Ra26, Rb1, Rc1, Rd14), (Ra26, Rb1, Rc1, Rd15), (Ra26, Rb1, Rc1, Rd17), (Ra26, Rb1, Rc1, Rd18), (Ra26, Rb1, Rc1, Rd19), (Ra26, Rb1, Rc1, Rd20), (Ra26, Rb1, Rc1, Rd22), (Ra26, Rb1, Rc1, Rd23), (Ra26, Rb1, Rc1, Rd24), (Ra26, Rb1, Rc1, Rd25), (Ra26, Rb1, Rc1, Rd27), (Ra26, Rb1, Rc1, Rd28), (Ra26, Rb1, Rc1, Rd29), (Ra26, Rb1, Rc2, Rd1), (Ra26, Rb1, Rc2, Rd3), (Ra26, Rb1, Rc2, Rd4), (Ra26, Rb1, Rc2, Rd5), (Ra26, Rb1, Rc2, Rd6), (Ra26, Rb1, Rc2, (Rd8), (Ra26, Rb1, Rc2, Rd9), (Ra26, Rb1, Rc2, Rd10), (Ra26, Rb1, Rc2, cRd11), (Ra2 6, Rb1, Rc2, Rd12), (Ra26, Rb1, Rc2, Rd13), (Ra26, Rb1, Rc2, Rd14), (Ra26, Rb1, Rc2, Rd15), (Ra26, Rb1, Rc2, Rd16), ( Ra26, Rb1, Rc2, Rd17), (Ra26, Rb1, Rc2, Rd18), (Ra26, Rb1, Rc2, Rd19), (Ra26, Rb1, Rc2, Rd20), (Ra26, Rb1, Rc2, Rd21), ( Ra26, Rb1, Rc2, Rd22), (Ra26, Rb1, Rc2, Rd24), (Ra26, Rb1, Rc2, Rd25), (Ra26, Rb1, Rc2, Rd26), ( (Ra26, Rb1, Rc2, Rd27), (Ra26, Rb1, Rc2, Rd29), (Ra26, Rb1, Rc3, Rd1), (Ra26, Rb1, Rc3, Rd2), ( (Ra26, Rb1, Rc3, Rd3), (Ra26, Rb1, Rc3, Rd4), (Ra26, Rb1, Rc3, Rd5), (Ra26, Rb1, Rc3, Rd6), (Ra26, Rb1,6Rc3, Rd7), (Ra26, Rb1, Rc3, Rd8), (Ra26, Rb1, Rc3, (Rd9), (Ra26, Rb1, Rc3, Rd10), (Ra26, Rb1, Rc3, Rd11), (Ra26, Rb1, Rc3, Rd12), (Ra26, Rb1, Rc3, Rd13), (Ra26, Rb1, Rc3, Rd14), (Ra26, Rb1, Rc3, Rd15), (Ra26, Rb1, Rc3, Rd16), (Ra26, Rb1, Rc3, Rd17), Ra26, Rb1, Rc3, 18Rd18), (Ra26 , Rb1, Rc3, Rd19), (Ra26, Rb1, Rc3, Rd20), (Ra26, Rb1, Rc3, Rd21), (Ra26, Rb1, Rc3, Rd22), (Ra26, Rb1, Rc3, Rd23), (Ra26 , Rb1, Rc3, Rd24), (Ra26, Rb1, Rc3, Rd25), (Ra26, Rb1, Rc3, Rd26), (Ra26, Rb1, Rc3, Rd27), (Ra26, Rb1, Rc3, Rd28), (Ra26 , Rb1, Rc3, Rd29), (Ra26, Rb1, Rc4, Rd1), (Ra26, Rb1, Rc4, Rd2), (Ra26, Rb1, Rc4, Rd3), (Ra26, Rb1, Rc4, Rd4), (Ra26 , Rb1, Rc4, Rd5), (Ra26, Rb1, Rc4, Rd6), (Ra26, Rb1, Rc4, Rd7), (Ra26, Rb1, Rc4, Rd8), (Ra26, Rb1, Rc4, Rd9), (Ra26 , Rb1, Rc4, Rd10), (Ra26, Rb1, Rc4, Rd11), (Ra26, Rb1, Rc4, Rd12), (Ra26, Rb1, Rc4, Rd13), (Ra26, Rb1, Rc4, Rd14), (Ra26 , Rb1, Rc4, Rd15), (Ra26, Rb1, Rc4, Rd16), (Ra26, Rb1, Rc4, Rd17), (Ra26, Rb1, Rc4, Rd18), (Ra26, Rb1, Rc4, Rd19), (Ra26 , Rb1, Rc4, Rd20), (Ra26, Rb1, Rc4, Rd21), (Ra26, Rb1, Rc4, Rd22), (Ra26, Rb1, Rc4, Rd23), (Ra26, Rb1, Rc4, Rd24), (Ra26 , Rb1, Rc4, Rd25), (Ra26, Rb1, Rc4, Rd26), (Ra26, Rb1, Rc4, Rd27), (Ra26, Rb1, Rc4, Rd28), (Ra26, Rb1, Rc4, Rd29), (Ra26, Rb1, Rc5, Rd1), (Ra26, Rb1, Rc5, Rd2), (Ra26, Rb1, Rc5, Rd3), (Ra26, Rb1, Rc5, Rd4), (Ra26, Rb1, Rc5, Rd5), (Ra26, Rb1, Rc5, Rd6), (Ra26, Rb1, Rc5, Rd7), (Ra26, Rb1, Rc5, Rd8), (Ra26, Rb1, Rc5, Rd9), (Ra26, Rb1, Rc5, Rd10), (Ra26, Rb1, Rc5, Rd11), (Ra26, Rb1, Rc5, Rd12), (Ra26, Rb1, Rc5, Rd13), (Ra26, Rb1, Rc5, Rd14), (Ra26, Rb1, Rc5, Rd15), (Ra26, Rb1, Rc5, Rd16), (Ra26, Rb1, Rc5, Rd17), (Ra26, Rb1, Rc5, Rd18), (Ra26, Rb1, Rc5, Rd19), (Ra26, Rb1, Rc5, Rd20), (Ra26, Rb1, Rc5, Rd21), (Ra26, Rb1, Rc5, Rd22), (Ra26, Rb1, Rc5, Rd23), (Ra26, Rb1, Rc5, Rd24), (Ra26, Rb1, Rc5, Rd25), (Ra26, Rb1, Rc5, Rd26), (Ra26, Rb1, Rc5, Rd27), (Ra26, Rb1, Rc5, Rd28), (Ra26, Rb1, Rc5, Rd29), (Ra26, Rb2, Rc1, Rd1), (Ra26, Rb2, Rc1, Rd2), (Ra26, Rb2, Rc1, Rd3), (Ra26, Rb 2, Rc1, Rd4), (Ra26, Rb2, Rc1, Rd5), (Ra26, Rb2, Rc1, Rd6), (Ra26, Rb2, Rc1, Rd7), (Ra26, Rb2, Rc1, Rd8), (Ra26, Rb2, Rc1, Rd9), (Ra26, Rb2, Rc1, Rd10), (Ra26, Rb2, Rc1, Rd11), (Ra26, Rb2, Rc1, Rd12), (Ra26, Rb2, Rc1, Rd13), (Ra26, Rb2, Rc1, Rd14), (Ra26, Rb2, Rc1, Rd15), (Ra26, Rb2, Rc1, Rd16), (Ra26, Rb2, Rc1, Rd17), (Ra26, Rb2, Rc1, Rd18), (Ra26, Rb2, Rc1, Rd19), (Ra26, Rb2, Rc1, Rd21), (Ra26, Rb2, Rc1, Rd22), (Ra26, Rb2, Rc1, Rd23), (Ra26, Rb2, Rc1, Rd24), (Ra26, Rb2, Rc1, Rd25), (Ra26, Rb2, Rc1, Rd26), (Ra26, Rb2, Rc1, Rd27), (Ra26, Rb2, Rc1, Rd28), (Ra26, Rb2, Rc1, Rd29), (Ra26, Rb2, Rc2, Rd1), (Ra26, Rb2, Rc2, Rd3), (Ra26, Rb2, Rc2, Rd4), (Ra26, Rb2, Rc2, Rd5), (Ra26, Rb2, Rc2, Rd6), (Ra26, Rb2, Rc2, Rd7), (Ra26, Rb2, Rc2, Rd8), (Ra26, Rb2, Rc2, Rd9), (Ra26, Rb2, Rc2, Rd10), (Ra26, Rb2, Rc2 , Rd11), (Ra26, Rb2, bRc2, Rd12), (Ra26, Rb2, Rc2, Rd14), (Ra26, Rb2, Rc2, Rd15), (Ra26, Rb2, Rc2) , Rd16), (Ra26, bRb2, Rc2, Rd17), (Ra26, Rb2, Rc2, Rd18), (Ra26, Rb2, Rc2, Rd19), (Ra26, Rb2, Rc2, Rd20), (Ra26, Rb2, Rc2 , Rd21), (Ra26, Rb2, Rd2, RaRd22), (Ra26, Rb2, Rc2, Rd24), (Ra26, Rb2, Rc2, Rd25), (Ra26, Rb2, Rc2 , Rd26), (Ra26, bRb2, Rc2, Rd27), (Ra26, Rb2, Rc2, Rd28), (Ra26, Rb2, Rc2, Rd29), (Ra26, Rb2, Rc3, Rd1), (Ra26, Rb2, Rc3 , Rd2), (Ra26, Rb2, Rd3), (Ra26, Rb2, Rc3, Rd5), (Ra26, Rb2, Rc3, Rd6), (Ra26, Rb2, Rc3) , Rd7), (Ra26, Rb2, Rc3, dRd9), (Ra26, Rb2, Rc3, Rd10), (Ra26, Rb2, Rc3, Rd11), (Ra26, Rb2, Rc3) , Rd12), (Ra26, Rb2, Rc3,) Rd13), (Ra26, Rb2, Rc3, Rd15), (Ra26, Rb2, Rc3, Rd16), (Ra26, Rb2, Rc3) , Rd17), (Ra26, Rb2, Rc3, Rd18), (Ra26, Rb2, Rc3, Rd19), (Ra26, Rb2, Rc3, Rd20), (Ra26, Rb2, Rc3, Rd21), (Ra26, Rb2, Rc3, Rd22), (Ra26, Rb2, Rc3, Rd23), (Ra26, Rb2, Rc3, Rd24), (Ra26, Rb2, Rc3, Rd26), (Ra26, Rb2, Rc3, Rd26), (Ra26, Rb2, Rc3, Rd27), (Ra26, Rb2, Rc3, Rd28), (Ra26, Rb2, Rc3, Rd29), (Ra26, Rb2, Rc4, Rd1), (Ra26, Rb2, Rc4, Rd2), (Ra26, Rb2, Rc4, Rd3), (Ra26, Rb2, Rc4, Rd4), (Ra26, Rb2, Rc4, Rd5), (Ra26, Rb2, Rc4, Rd6), (Ra26, Rb2, Rc4, Rd7), (Ra26, Rb2, Rc4, Rd8), (Ra26, Rb2, Rc4, Rd9), (Ra26, Rb2, Rc4, Rd10), (Ra26, Rb2, Rc4, Rd11), (Ra26, Rb2, Rc4, Rd12), (Ra26, Rb2, Rc4, Rd13), (Ra26, Rb2, Rc4, Rd14), (Ra26, Rb2, Rc4, Rd15), (Ra26, Rb2, Rc4, Rd16), (Ra26, Rb2, Rc4, Rd17), (Ra26, Rb2, Rc4, Rd18), (Ra26, Rb2, Rc4, Rd19), (Ra26, Rb2, Rc4, Rd20), (Ra26, Rb2, Rc4, Rd21), (Ra26, Rb2, Rc4, Rd22), (Ra26, Rb2, Rc4, Rd23), (Ra26, Rb2, Rc4, Rd24), (Ra26, Rb2, Rc4, Rd25), (Ra26, Rb2, Rc4, Rd26), (Ra26, Rb2, Rc4, Rd28), (Ra26, Rb2, Rc4, Rd28), (Ra26, Rb2, Rc4, Rd29), (Ra26, Rb2, Rc5, Rd1), (Ra26, Rb2, Rc5, Rd2), (Ra26, Rb2, Rc5, Rd3), (Ra26, Rb2, Rc5, Rd4), (Ra26, Rb2, Rc5, Rd5), (Ra26, Rb2, Rc5, Rd6), (Ra26, Rb2, Rc5, Rd7), (Ra26, Rb2, Rc5, Rd8), (Ra26, Rb2, Rc5, Rd9), (Ra26, Rb2, Rc5, Rd10), (Ra26, Rb2, Rc5, Rd11), (Ra26, Rb2, Rc5, Rd12), (Ra26, Rb2, Rc5, Rd13), (Ra26, Rb2, Rc5, Rd14), (Ra26, Rb2, Rc5, Rd15), (Ra26, Rb2, Rc5, Rd16), (Ra26, Rb2, Rc5, Rd17), (Ra26, Rb2, Rc5, Rd18), (Ra26, Rb2, Rc5, Rd19), (Ra26, Rb2, Rc5, Rd20), (Ra26, Rb2, Rc5, Rd21), (Ra26, Rb2, Rc5, Rd22), (Ra26, Rb2, Rc5, Rd23), (Ra26, Rb2, Rc5, Rd24), (Ra26, Rb2, Rc5, Rd25), (Ra26, Rb2, Rc5, Rd26), (Ra26, Rb2, Rc5, Rd27), (Ra26, Rb2, Rc5, Rd28), (Ra26, Rb2, Rc5, Rd29), (Ra27, Rb1, Rc1, Rd1), (Ra27, Rb1, Rc1, Rd2), (Ra27, Rb1, Rc1, Rd (3), (Ra27, Rb1, Rc1, Rd4), (Ra27, Rb1, Rc1, Rd5), (Ra27, Rb1, Rc1, Rd6), (Ra27, Rb1, Rc1, Rd7), (Ra27, Rb1, Rc1, Rd8), (Ra27, Rb1, Rc1, Rd9), (Ra27, Rb1, Rc1, Rd10), (Ra27, Rb1, Rc1, Rd11), (Ra27, Rb1, Rc1, Rd12), (Ra27, Rb1, Rc1, Rd13), (Ra27, Rb1, Rc1, Rd14), (Ra27, Rb1, Rc1, Rd15), (Ra27, Rb1, Rc1, Rd16), (Ra27, Rb1, Rc1, Rd17), (Ra27, Rb1, Rc1, Rd18), (Ra27, Rb1, Rc1, Rd19), (Ra27, Rb1, Rc1, Rd20), (Ra27, Rb1, Rc1, Rd21), (Ra27, Rb1, Rc1, Rd22), (Ra27, Rb1, Rc1, Rd23), (Ra27, Rb1, Rc1, Rd24), (Ra27, Rb1, Rc1, Rd25), (Ra27, Rb1, Rc1, Rd26), (Ra27, Rb1, Rc1, Rd27), (Ra27, Rb1, Rc1, Rd28), (Ra27, Rb1, Rc1, Rd29), (Ra27, Rb1, Rc2, Rd1), (Ra27, Rb1, Rc2, Rd2), (Ra27, Rb1, Rc2, Rd3), (Ra27, Rb1, Rc2, Rd4), (Ra27, Rb1, Rc2, Rd5), (Ra27, Rb1, Rc2, Rd6), (Ra27, Rb1, Rc2, Rd7), (Ra27, Rb1, Rc2, Rd8), (Ra27, Rb1, Rc2, Rd9), (Ra27, Rb1, Rc2, Rd10), (R a27, Rb1, Rc2, 11Rd11), (Ra27, Rb1, Rc2, Rd12), (Ra27, Rb1, Rc2, Rd13), (Ra27, Rb1, Rc2, Rd14), (Ra27, Rb1, Rc2, Rd15), ( Ra27, Rb1, Rc2, Rd16), (Ra27, Rb1, Rc2, Rd18), (Ra27, Rb1, Rc2, Rd19), (Ra27, Rb1, Rc2, Rd20), ( Ra27, Rb1, Rc2, 21Rd21), (Ra27, Rb1, Rc2, Rd23), (Ra27, Rb1, Rc2, Rd24), (Ra27, Rb1, Rc2, Rd25), ( Ra27, Rb1, Rc2, Rd26), (Ra27, Rb1, Rc2, Rd27), (Ra27, Rb1, Rc2, Rd28), (Ra27, Rb1, Rc2, Rd29), (Ra27, Rb1, Rc3, Rd1), ( (Ra27, Rb1, Rc3, 2Rd2), (Ra27, Rb1, Rc3, Rd3), (Ra27, Rb1, Rc3, Rd4), (Ra27, Rb1, Rc3, Rd5), (Ra27, Rb1, Rc3, Rd6), (Ra27, Rb1, Rc3, Rd7), (Ra27, Rb1, Rc3, Rd8), (Ra27, Rb1, Rc3, Rd9), (Ra27, Rb1, Rc3, Rd10), (Ra27, Rb1, Rc3, Rd11), (Ra27, Rb1, Rc3, Rd12), (Ra27, Rb1, Rc3, Rd13), (Ra27, Rb1, Rc3, Rd14), (Ra27, Rb1, Rc3, Rd15), (Ra27, Rb1, Rc3, Rd16), Ra27, Rb1, Rc3, Rd17), (Ra 27, Rb1, Rc3, Rd18), (Ra27, Rb1, Rc3, Rd19), (Ra27, Rb1, Rc3, Rd20), (Ra27, Rb1, Rc3, Rd21), (Ra27, Rb1, Rc3, Rd22), Ra27, Rb1, Rc3, Rd23), (Ra27, Rb1, Rc3, Rd24), (Ra27, Rb1, Rc3, Rd25),

(Ra27, Rb1, Rc3, Rd26), (Ra27, Rb1, Rc3, Rd27), (Ra27, Rb1, Rc3, Rd28), (Ra27, Rb1, Rc3, Rd29), (Ra27, Rb1, Rc4, Rd1), (Ra27, Rb1, Rc4, Rd2), (Ra27, Rb1, Rc4, Rd3), (Ra27, Rb1, Rc4, Rd4), (Ra27, Rb1, Rc4, Rd5), (Ra27, Rb1, Rc4, Rd6), (Ra27, Rb1, Rc4, Rd7), (Ra27, Rb1, Rc4, Rd8), (Ra27, Rb1, Rc4, Rd9), (Ra27, Rb1, Rc4, Rd10), (Ra27, Rb1, Rc4, Rd11), (Ra27, Rb1, Rc4, Rd12), (Ra27, Rb1, Rc4, Rd13), (Ra27, Rb1, Rc4, Rd14), (Ra27, Rb1, Rc4, Rd15), (Ra27, Rb1, Rc4, Rd16), (Ra27, Rb1, Rc4, 17Rd17), (Ra27, Rb1, Rc4, Rd18), (Ra27, Rb1, Rc4, Rd19), (Ra27, Rb1, Rc4, Rd20), (Ra27, Rb1, Rc4, Rd21), (Ra27, Rb1, Rc4, Rd22), (Ra27, Rb1, Rc4, Rd23), (Ra27, Rb1, Rc4, Rd24), (Ra27, Rb1, Rc4, Rd25), (Ra27, Rb1, Rc4, Rd26), (Ra27, Rb1, Rc4, Rd27), (Ra27, Rb1, Rc4, Rd28), (Ra27, Rb1, Rc4, Rd29), (Ra27, Rb1, Rc5, Rd1), (Ra27, Rb1, Rc5, Rd2), (Ra27, Rb1, Rc5, Rd3), (R a27, Rb1, Rc5, Rd4), (Ra27, Rb1, Rc5, Rd5), (Ra27, Rb1, Rc5, Rd6), (Ra27, Rb1, Rc5, Rd7), (Ra27, Rb1, Rc5, Rd8), (Ra27, Rb1, Rc5, Rd9), (Ra27, Rb1, Rc5, Rd10), (Ra27, Rb1, Rc5, Rd11), (Ra27, Rb1, Rc5, Rd12), (Ra27, Rb1, Rc5, Rd13), (Ra27, Rb1, Rc5, Rd14), (Ra27, Rb1, Rc5, Rd15), (Ra27, Rb1, Rc5, Rd16), (Ra27, Rb1, Rc5, Rd17), (Ra27, Rb1, Rc5, Rd18), (Ra27, Rb1, cRc5, Rd19), (Ra27, Rb1, Rc5, Rd20), (Ra27, Rb1, Rc5, Rd21), (Ra27, Rb1, Rc5, Rd22), (Ra27, Rb1, Rc5, Rd23), (Ra27, Rb1, cRc5, Rd24), (Ra27, Rb1, Rc5, Rd25), (Ra27, Rb1, Rc5, Rd26), (Ra27, Rb1, Rc5, Rd27), (Ra27, Rb1, Rc5, Rd28), Ra27, Rb1, Rc5, Rd29), (Ra27, Rb2, Rc1, Rd1), (Ra27, Rb2, Rc1, Rd2), (Ra27, Rb2, Rc1, Rd3), (Ra27, Rb2, Rc1, Rd4), ( Ra27, Rb2, Rc1, Rd5), (Ra27, Rb2, Rc1, Rd6), (Ra27, Rb2, Rc1, Rd7), (Ra27, Rb2, Rc1, Rd8), (Ra27, Rb2, Rc1, Rd9), ( Ra27, Rb2, Rc1, Rd10), (Ra27, R b2, Rc1, Rd11), (Ra27, Rb2, Rc1, Rd12), (Ra27, Rb2, Rc1, Rd13), (Ra27, Rb2, Rc1, Rd14), (Ra27, Rb2, Rc1, Rd15), (Ra27, Rb2, Rc1, Rd16), (Ra27, Rb2, Rc1, Rd17), (Ra27, Rb2, Rc1, Rd18), (Ra27, Rb2, Rc1, Rd19), (Ra27, Rb2, Rc1, Rd20), (Ra27, Rb2, Rc1, Rd21), (Ra27, Rb2, Rc1, Rd22), (Ra27, Rb2, Rc1, Rd23), (Ra27, Rb2, Rc1, Rd24), (Ra27, Rb2, Rc1, Rd25), (Ra27, Rb2, Rc1, Rd26), (Ra27, Rb2, Rc1, Rd27), (Ra27, Rb2, Rc1, Rd28), (Ra27, Rb2, Rc1, Rd29), (Ra27, Rb2, Rc2, Rd1), (Ra27, Rb2, Rc2, Rd2), (Ra27, Rb2, Rc2, Rd3), (Ra27, Rb2, Rc2, Rd4), (Ra27, Rb2, Rc2, Rd5), (Ra27, Rb2, Rc2, Rd6), (Ra27, Rb2, Rc2, Rd7), (Ra27, Rb2, Rc2, Rd8), (Ra27, Rb2, Rc2, Rd9), (Ra27, Rb2, Rc2, Rd10), (Ra27, Rb2, Rc2, Rd11), (Ra27, Rb2, Rc2, Rd12), (Ra27, Rb2, Rc2, Rd13), (Ra27, Rb2, Rc2, Rd14), (Ra27, Rb2, Rc2, Rd15), (Ra27, Rb2, Rc2, Rd16), (Ra27, Rb2, Rc2, Rd17), (Ra27, Rb 2, Rc2, Rd18), (Ra27, Rb2, Rc2, Rd19), (Ra27, Rb2, Rc2, Rd20), (Ra27, Rb2, Rc2, Rd21), (Ra27, Rb2, Rc2, Rd22), (Ra27, Rb2, Rc2, Rd23), (Ra27, Rb2, Rc2, Rd24), (Ra27, Rb2, Rc2, Rd25), (Ra27, Rb2, Rc2, Rd26), (Ra27, Rb2, Rc2, Rd27), (Ra27, Rb2, Rc2, Rd28), (Ra27, Rb2, Rc2, Rd29), (Ra27, Rb2, Rc3, Rd1), (Ra27, Rb2, Rc3, Rd2), (Ra27, Rb2, Rc3, Rd3), (Ra27, Rb2, Rc3, Rd4), (Ra27, Rb2, Rc3, Rd5), (Ra27, Rb2, Rc3, Rd6), (Ra27, Rb2, Rc3, Rd7), (Ra27, Rb2, Rc3, Rd8), (Ra27, Rb2, Rc3, Rd9), (Ra27, Rb2, Rc3, Rd10), (Ra27, Rb2, Rc3, Rd11), (Ra27, Rb2, Rc3, Rd12), (Ra27, Rb2, Rc3, Rd13), (Ra27, Rb2, Rc3, Rd14), (Ra27, Rb2, Rc3, Rd15), (Ra27, Rb2, Rc3, Rd16), (Ra27, Rb2, Rc3, Rd17), (Ra27, Rb2, Rc3, Rd18), (Ra27, Rb2, Rc3, Rd19), (Ra27, Rb2, Rc3, Rd20), (Ra27, Rb2, Rc3, Rd21), (Ra27, Rb2, Rc3, Rd22), (Ra27, Rb2, Rc3, Rd23), (Ra27, Rb2, Rc3, Rd24), (Ra27, Rb2 , Rc3, Rd25), (Ra27, Rb2, Rc3, Rd26), (Ra27, Rb2, Rc3, Rd27), (Ra27, Rb2, Rc3, Rd28), (Ra27, Rb2, Rc3, Rd29), (Ra27, Rb2) , Rc4, dRd1), (Ra27, Rb2, Rc4, Rd2), (Ra27, Rb2, Rc4, Rd3), (Ra27, Rb2, Rc4, Rd4), (Ra27, Rb2, Rc4, Rd5), (Ra27, Rb2) , Rc4, Rd6), (Ra27, Rb2, Rc4, Rd7), (Ra27, Rb2, Rc4, Rd8), (Ra27, Rb2, Rc4, Rd9), (Ra27, Rb2, Rc4, Rd10), (Ra27, Rb2) , Rc4, dRd11), (Ra27, Rb2, Rc4, Rd12), (Ra27, Rb2, Rc4, Rd13), (Ra27, Rb2, Rc4, Rd14), (Ra27, Rb2, Rc4, Rd15), (Ra27, Rb2) , Rc4, Rd16), (Ra27, Rb2, Rc4, Rd17), (Ra27, Rb2, Rc4, Rd19), (Ra27, Rb2, Rc4, Rd20), (Ra27, Rb2) , Rc4, Rd21), (Ra27, Rb2, Rc4, Rd22), (Ra27, Rb2, Rc4, Rd23), (Ra27, Rb2, Rc4, Rd24), (Ra27, Rb2, Rc4, Rd25), (Ra27, Rb2) , Rc4, Rd26), (Ra27, Rb2, Rc4, Rd27), (Ra27, Rb2, Rc4, Rd28), (Ra27, Rb2, Rc4, Rd29), (Ra27, Rb2, Rc5, Rd1), (Ra27, Rb2) , Rc5, Rd2), (Ra27, Rb2, Rc5, Rd3), (Ra27, Rb2, Rc5, Rd4), (Ra27, Rb2, Rc5, Rd5), (Ra27, Rb2, Rc5, Rd6), (Ra27, Rb2, Rc5, Rd7), (Ra27, Rb2, Rc5, Rd8), (Ra27, Rb2, Rc5, Rd9), (Ra27, Rb2, Rc5, Rd10), (Ra27, Rb2, Rc5, Rd11), (Ra27, Rb2, Rc5, Rd12), (Ra27, Rb2, Rc5, Rd13), (Ra27, Rb2, Rc5, Rd14), (Ra27, Rb2, Rc5, Rd15), (Ra27, Rb2, Rc5, Rd16), (Ra27, Rb2, Rc5, Rd17), (Ra27, Rb2, Rc5, Rd18), (Ra27, Rb2, Rc5, Rd19), (Ra27, Rb2, Rc5, Rd20), (Ra27, Rb2, Rc5, Rd21), (Ra27, Rb2, Rc5, Rd22), (Ra27, Rb2, Rc5, Rd23), (Ra27, Rb2, Rc5, Rd24), (Ra27, Rb2, Rc5, Rd25), (Ra27, Rb2, Rc5, Rd26), (Ra27, Rb2, Rc5, Rd27), (Ra27, Rb2, Rc5, Rd28), (Ra27, Rb2, Rc5, Rd29),

(Ra1, Rb1, Rcc1, Rdd1), (Ra1, Rb1, Rcc1, Rdd3), (Ra1, Rb1, Rcc1, Rdd4), (Ra1, Rb1, Rcc1, Rdd5), (Ra1, Rb1, Rcc1, Rdd6), (Ra1, Rb1, Rcc1, Rdd8), (Ra1, Rb1, Rcc2, Rdd1), (Ra1, Rb1, Rcc2, Rdd2), (Ra1, Rb1, Rcc2, Rdd3), (Ra1, Rb1, Rcc2, Rdd5), (Ra1, Rb1, Rcc2, Rdd6), (Ra1, Rb1, Rcc2, Rdd7), (Ra1, Rb1, Rcc2, Rdd8), (Ra1, Rb2, Rcc1, Rdd2), (Ra1, Rb2, Rcc1, Rdd3), (Ra1, Rb2, Rcc1, Rdd4), (Ra1, Rb2, Rcc1, Rdd5), (Ra1, Rb2, Rcc1, Rdd7), (Ra1, Rb2, Rcc1, Rdd8), (Ra1, Rb2, Rcc2, Rdd1), (Ra1, Rb2, Rcc2, Rdd2), (Ra1, Rb2, Rcc2, Rdd4), (Ra1, Rb2, Rcc2, Rdd5), (Ra1, Rb2, Rcc2, Rdd6), (Ra1, Rb2, Rcc2, Rdd7), (Ra1, Rb2, Rcc2, Rdd8), (Ra2, Rb1, Rcc1, Rdd1), (Ra2, Rb1, Rcc1, Rdd2), (Ra2, Rb1, Rcc1, Rdd3), (Ra2, Rb1, Rcc1, Rdd4), (Ra2, Rb1, Rcc1, Rdd5), (Ra2, Rb1, Rcc1, Rdd6), (Ra2, Rb1, Rcc1, Rdd7), (Ra2, Rb1, Rcc1, Rdd8), (Ra2, Rb1, Rcc2, Rdd1), (Ra2, Rb1, Rcc2, Rdd2), (Ra2, Rb1, Rcc2, Rdd3), (Ra2, Rb1, Rcc2, Rdd4), (Ra2, Rb1, Rcc2, Rdd5), (Ra2, Rb1, Rcc2, Rdd6), (Ra2, Rb1, Rcc2, Rdd7), (Ra2, Rb1, Rcc2, Rdd8), (Ra2, Rb2, Rcc1, Rdd1), (Ra2, Rb2, Rcc1, Rdd2), (Ra2, Rb2, Rcc1, Rdd3), (Ra2, Rb2, Rcc1, Rdd4), (Ra2, Rb2, Rcc1, Rdd5), (Ra2, Rb2, Rcc1, Rdd6), (Ra2, Rb2, Rcc1, Rdd7), (Ra2, Rb2, Rcc1, Rdd8), (Ra2, Rb2, Rcc2, Rdd1), (Ra2, Rb2, Rcc2, Rdd2), (Ra2, Rb2, Rcc2, Rdd3), (Ra2, Rb2, Rcc2, Rdd4), (Ra2, Rb2, Rcc2, Rdd5), (Ra2, Rb2, Rcc2, Rdd6), (Ra2, Rb2, Rcc2, Rdd7), (Ra2, Rb2, Rcc2, Rdd8), (Ra3, Rb1, Rcc1, Rdd1), (Ra3, Rb1, Rcc1, Rdd2), (Ra3, Rb1, Rcc1, Rdd3), (Ra3, Rb1, Rcc1, Rdd4), (Ra3, Rb1, Rcc1, Rdd5), (Ra3, Rb1, Rcc1, Rdd6), (Ra3, Rb1, Rcc1, Rdd7), (Ra3, Rb1, Rcc1, Rdd8), (Ra3, Rb1, Rcc2, Rdd1), (Ra3, Rb1, Rcc2, Rdd2), (Ra3, Rb1, Rcc2, Rdd3), (Ra3, Rb1, Rcc2, Rdd4), (Ra3, Rb1, Rcc2, Rdd5), (Ra3, Rb1, Rcc2, Rdd6), (Ra3, Rb1, Rcc2, Rdd7), (Ra3, Rb1, Rcc2, Rdd8), (Ra3, Rb2, Rcc1, Rdd1), (Ra3, Rb2, Rcc1, Rdd2), (Ra3, Rb2, Rcc1, Rdd3), (Ra3, Rb2, Rcc1, Rdd4), (Ra3, Rb2, Rcc1, Rdd5), (Ra3, Rb2, Rcc1, Rdd6), (Ra3, Rb2, Rcc1, Rdd7), (Ra3, Rb2, Rcc1, Rdd8), (Ra3, Rb2, Rcc2, Rdd1), (Ra3, Rb2, Rcc2, Rdd2), (Ra3, Rb2, Rcc2, Rdd3), (Ra3, Rb2, Rcc2, Rdd4), (Ra3, Rb2, Rcc2, Rdd5), (Ra3, Rb2, Rcc2, Rdd6), (Ra3, Rb2, Rcc2, Rdd7), (Ra3, Rb2, Rcc2, Rdd8), (Ra4, Rb1, Rcc1, Rdd1), (Ra4, Rb1, Rcc1, Rdd2), (Ra4, Rb1, Rcc1, Rdd3), (Ra4, Rb1, Rcc1, Rdd4), (Ra4, Rb1, Rcc1, Rdd5), (Ra4, Rb1, Rcc1, Rdd6), (Ra4, Rb1, Rcc1, Rdd7), (Ra4, Rb1, Rcc1, Rdd8), (Ra4, Rb1, Rcc2, Rdd1), (Ra4, Rb1, Rcc2, Rdd2), (Ra4, Rb1, Rcc2, Rdd3), (Ra4 , Rb1, Rcc2, Rdd4), (Ra4, Rb1, Rcc2, (Rdd6), (Ra4, Rb1, Rcc2, Rdd7), (Ra4, Rb1, Rcc2, Rdd8), (Ra4 , Rb2, Rcc1, Rdd1), (Ra4, Rb2, Rcc1, Rdd3), (Ra4, Rb2, Rcc1, Rdd4), (Ra4, Rb2, Rcc1, Rdd5), (Ra4 , Rb2, Rcc1, Rdd6), (Ra4, Rb2, Rcc1, Rdd7), (Ra4, Rb2, Rcc1, Rdd8), (Ra4, Rb2, Rcc2, Rdd1), (Ra4, Rb2, Rcc2, Rdd2), (Ra4 , Rb2, Rcc2, Rdd3), (Ra4, Rb2, Rcc2, Rdd5), (Ra4, Rb2, Rcc2, Rdd6), (Ra4, Rb2, Rcc2, Rdd7), (Ra4 , Rb2, Rcc2, Rdd8), (Ra5, Rb1, Rcc1, (Rdd2), (Ra5, Rb1, Rcc1, Rdd3), (Ra5, ddRb1, Rcc1, Rdd4), (Ra5 , Rb1, Rcc1, Rdd5), (Ra5, Rb1, Rcc1, Rdd7), (Ra5, Rb1, Rcc1, Rdd8), (Ra5, Rb1, Rcc2, Rdd1), (Ra5 , Rb1, Rcc2, Rdd2), (Ra5, Rb1, Rcc2, (Rdd4), (Ra5, Rb1, Rcc2, Rdd5), (Ra5, Rb1, Rcc2, Rdd6), (Ra5 , Rb1, Rcc2, Rdd7 ), (Ra5, Rb1, Rcc2, 8Rdd8), (Ra5, Rb2, Rcc1, Rdd1), (Ra5, Rb2, Rcc1, Rdd2), (Ra5, Rb2, Rcc1, Rdd3), (Ra5, Rb2, Rcc1, Rdd4) ), (Ra5, Rb2, Rcc1, Rdd5), (Ra5, Rb2, Rcc1, (Rdd6), (Ra5, Rb2, Rcc1, Rdd7), (Ra5, Rb2, Rcc1, Rdd8), (Ra5, Rb2, Rcc2, Rdd1 ), (Ra5, Rb2, Rcc2, Rdd2), (Ra5, Rb2, Rcc2, Rdd3), (Ra5, Rb2, Rcc2, Rdd4), (Ra5, Rb2, Rcc2, Rdd5), (Ra5, Rb2, Rcc2, Rdd6) ), (Ra5, Rb2, Rcc2, Rdd7), (Ra5, Rb2, Rcc2, Rdd8), (Ra6, Rb1, Rcc1, Rdd1), (Ra6, Rb1, Rcc1, Rdd2), (Ra6, Rb1, Rcc1, Rdd3) ), (Ra6, Rb1, Rcc1, Rdd4), (Ra6, Rb1, Rcc1, Rdd5), (Ra6, Rb1, Rcc1, Rdd6), (Ra6, Rb1, Rcc1, Rdd7), (Ra6, Rb1, Rcc1, Rdd8) ), (Ra6, Rb1, Rcc2, Rdd1), (Ra6, RaRb1, Rcc2, Rdd3), (Ra6, Rb1, Rcc2, Rdd4), (Ra6, Rb1, Rcc2, Rdd5) ), (Ra6, Rb1, Rcc2, Rdd6), (Ra6, Rb1, Rcc2, Rdd7), (Ra6, Rb1, Rcc2, Rdd8), (Ra6, Rb2, Rcc1, Rdd1), (Ra6, Rb2, Rcc1, Rdd2) ), (Ra6, Rb2, Rcc 1, Rdd3), (Ra6, Rb2, Rcc1, Rdd4), (Ra6, Rb2, Rcc1, Rdd5), (Ra6, Rb2, Rcc1, Rdd6), (Ra6, Rb2, Rcc1, Rdd7), (Ra6, Rb2, Rcc1, Rdd8), (Ra6, Rb2, Rcc2, Rdd1), (Ra6, Rb2, Rcc2, Rdd2), (Ra6, Rb2, Rcc2, Rdd3), (Ra6, Rb2, Rcc2, Rdd4), (Ra6, Rb2, Rcc2, Rdd5), (Ra6, Rb2, Rcc2, Rdd6), (Ra6, Rb2, Rcc2, Rdd7), (Ra6, Rb2, Rcc2, Rdd8), (Ra7, Rb1, Rcc1, Rdd1), (Ra7, Rb1, Rcc1, Rdd2), (Ra7, Rb1, Rcc1, Rdd3), (Ra7, Rb1, Rcc1, Rdd4), (Ra7, Rb1, Rcc1, Rdd5), (Ra7, Rb1, Rcc1, Rdd6), (Ra7, Rb1, Rcc1, Rdd7), (Ra7, Rb1, Rcc1, Rdd8), (Ra7, Rb1, Rcc2, Rdd1), (Ra7, Rb1, Rcc2, Rdd2), (Ra7, Rb1, Rcc2, Rdd3), (Ra7, Rb1, Rcc2, Rdd4), (Ra7, Rb1, Rcc2, Rdd5), (Ra7, Rb1, Rcc2, Rdd6), (Ra7, Rb1, Rcc2, Rdd7), (Ra7, Rb1, Rcc2, Rdd8), (Ra7, Rb2, Rcc1, Rdd1), (Ra7, Rb2, Rcc1, Rdd2), (Ra7, Rb2, Rcc1, Rdd3), (Ra7, Rb2, Rcc1, Rdd4), (Ra7, Rb2, Rcc1, Rdd5), (Ra7, Rb2, Rcc1, Rdd6), (Ra7, R b2, Rcc1, Rdd7), (Ra7, Rb2, Rcc1, Rdd8), (Ra7, Rb2, Rcc2, Rdd1), (Ra7, Rb2, Rcc2, Rdd2), (Ra7, Rb2, Rcc2, Rdd3), (Ra7, (Rb2, Rcc2, Rdd4), (Ra7, Rb2, Rcc2, Rdd6), (Ra7, Rb2, Rcc2, Rdd7), (Ra7, Rb2, Rcc2, Rdd8), (Ra8, (Rb1, Rcc1, Rdd1), (Ra8, Rb1, Rcc1, Rdd2), (Ra8, Rb1, Rcc1, Rdd4), (Ra8, Rb1, Rcc1, Rdd5), (Ra8, (Rb1, Rcc1, Rdd6), (Ra8, Rb1, Rcc1, Rdd7), (Ra8, Rb1, Rcc2, Rdd1), (Ra8, Rb1, Rcc2, Rdd2), (Ra8, Rb1, Rcc2, Rdd3), (Ra8, Rb1, Rcc2, Rdd6), (Ra8, Rb1, Rcc2, Rdd6), (Ra8, Rb1, Rcc2, Rdd7), (Ra8, Rb1, Rcc2, Rdd8), (Ra8, Rb2, Rcc1, Rdd1), (Ra8, Rb2, Rcc1, Rdd2), (Ra8, Rb2, Rcc1, Rdd3), (Ra8, Rb2, Rcc1, Rdd4), (Ra8, Rb2, Rcc1, Rdd5), (Ra8, Rb2, Rcc1, Rdd6), (Ra8, Rb2, Rcc1, Rdd7), (Ra8, Rb2, Rcc1, Rdd8), (Ra8, Rb2, Rcc2, Rdd1), (Ra8, Rb2, Rcc2, Rdd2), (Ra8, Rb2, Rcc2, Rdd3), (Ra8, Rb2, Rcc2, Rdd5), (Ra8, Rb2, Rcc2, Rdd6), (Ra8, Rb2, Rcc2, Rdd7), (Ra8, Rb2, Rcc2, Rdd8), (Ra9, Rb1, Rcc1, Rdd2), (Ra9, Rb1, Rcc1, Rdd3), (Ra9, Rb1, Rcc1, Rdd4), (Ra9, Rb1, Rcc1, Rdd5), (Ra9, Rb1, Rcc1, Rdd7), (Ra9, Rb1, Rcc1, Rdd8), (Ra9, Rb1, Rcc2, Rdd1), (Ra9, Rb1, Rcc2, Rdd2), (Ra9, Rb1, Rcc2, Rdd4), (Ra9, Rb1, Rcc2, Rdd5), (Ra9, Rb1, Rcc2, Rdd6), (Ra9, Rb1, Rcc2, Rdd7), (Ra9, Rb2, Rcc1, Rdd1), (Ra9, Rb2, Rcc1, Rdd2), (Ra9, Rb2, Rcc1, Rdd3), (Ra9, Rb2, Rcc1, Rdd4), (Ra9, Rb2, Rcc1, Rdd6), (Ra9, Rb2, Rcc1, Rdd7), (Ra9, Rb2, Rcc1, Rdd8), (Ra9, Rb2, Rcc2, Rdd1), (Ra9, Rb2, Rcc2, Rdd3), (Ra9, Rb2, Rcc2, Rdd4), (Ra9, Rb2, Rcc2, Rdd5), (Ra9, Rb2, Rcc2, Rdd6), (Ra9, Rb2, Rcc2, Rdd7), (Ra9, Rb2, Rcc2, Rdd8), (Ra10, Rb1, Rcc1, Rdd1), (Ra10, Rb1, Rcc1, Rdd2), (Ra10, Rb1, Rcc1, Rdd3), (Ra10, Rb1, Rcc1, Rdd4), (Ra10, Rb1, Rcc1, Rdd5), (Ra10, Rb1, Rcc1, Rdd6), (Ra10, Rb1, Rcc1, Rdd7), (Ra10, Rb1, Rcc1, Rdd8), (Ra10, Rb1, Rcc2, Rdd1), (Ra10, Rb1, Rcc2, Rdd2), (Ra10, Rb1, Rcc2, Rdd3), (Ra10, Rb1, Rcc2, Rdd4), (Ra10, Rb1, Rcc2, Rdd5), (Ra10, Rb1, Rcc2, Rdd6), (Ra10, Rb1, Rcc2, Rdd7), (Ra10, Rb1, Rcc2, Rdd8), (Ra10, Rb2, Rcc1, Rdd1), (Ra10, Rb2, Rcc1, Rdd2), (Ra10, Rb2, Rcc1, Rdd3), (Ra10, Rb2, Rcc1, Rdd4), (Ra10, Rb2, Rcc1, Rdd5), (Ra10, Rb2, Rcc1, Rdd6), (Ra10, Rb2, Rcc1, Rdd7), (Ra10, Rb2, Rcc1, Rdd8), (Ra10, Rb2, Rcc2, Rdd1), (Ra10, Rb2, Rcc2, Rdd2), (Ra10, Rb2, Rcc2, Rdd3), (Ra10, Rb2, Rcc2, Rdd4), (Ra10, Rb2, Rcc2, Rdd5), (Ra10, Rb2, Rcc2, Rdd6), (Ra10, Rb2, Rcc2, Rdd7), (Ra10, Rb2, Rcc2, Rdd8), (Ra11, Rb1, Rcc1, Rdd1), (Ra11, Rb1, Rcc1, Rdd2), (Ra11, Rb1, Rcc1, Rdd3), (Ra11, Rb1, Rcc1, Rdd4), (Ra11, Rb1, Rcc1, Rdd5), (Ra11, Rb1, Rcc1, Rdd6), (Ra11, Rb1, Rcc1, Rdd7), (Ra11, Rb1, Rcc1, Rdd8), (Ra11, Rb1, Rcc2, Rdd1), (Ra11, Rb1, Rcc2, Rdd2), (Ra11, Rb1, Rcc2, Rdd3), (Ra11, Rb1, Rcc2, Rdd6), (Ra11, Rb1, Rcc2, Rdd6), (Ra11, Rb1, Rcc2, Rdd7), (Ra11, (Rb1, Rcc2, Rdd8), (Ra11, Rb2, Rcc1, Rdd1), (Ra11, Rb2, Rcc1, Rdd2), (Ra11, Rb2, Rcc1, Rdd3), (Ra11, Rb2, Rcc1, Rdd4), (Ra11, (Rb2, Rcc1, Rdd5), (Ra11, Rb2, Rcc1, Rdd6), (Ra11, Rb2, Rcc1, Rdd8), (Ra11, Rb2, Rcc2, Rdd1), (Ra11, Rb2, Rcc2, Rdd2), (Ra11, Rb2, Rcc2, Rdd4), (Ra11, Rb2, Rcc2, Rdd5), (Ra11, Rb2, Rcc2, Rdd6), (Ra11, Rb2, Rcc2, Rdd7), (Ra11, Rb2, Rcc2, Rdd8), (Ra12, Rb1, Rcc1, Rdd1), (Ra12, Rb1, Rcc1, Rdd2), (Ra12, Rb1, Rcc1, R dd3), (Ra12, Rb1, Rcc1, Rdd4), (Ra12, Rb1, Rcc1, Rdd5), (Ra12, Rb1, Rcc1, Rdd6), (Ra12, Rb1, Rcc1, Rdd7), (Ra12, Rb1, Rcc1, Rdd8), (Ra12, Rb1, Rcc2, Rdd1), (Ra12, Rb1, Rcc2, Rdd2), (Ra12, Rb1, Rcc2, Rdd3), (Ra12, Rb1, Rcc2, Rdd4), (Ra12, Rb1, Rcc2, Rdd5), (Ra12, Rb1, Rcc2, Rdd6), (Ra12, Rb1, Rcc2, Rdd7), (Ra12, Rb1, Rcc2, Rdd8), (Ra12, Rb2, Rcc1, Rdd1), (Ra12, Rb2, Rcc1, Rdd2), (Ra12, Rb2, Rcc1, Rdd3), (Ra12, Rb2, Rcc1, Rdd4), (Ra12, Rb2, Rcc1, Rdd5), (Ra12, Rb2, Rcc1, Rdd6), (Ra12, Rb2, Rcc1, Rdd7), (Ra12, Rb2, Rcc1, Rdd8), (Ra12, Rb2, Rcc2, Rdd1), (Ra12, Rb2, Rcc2, Rdd2), (Ra12, Rb2, Rcc2, Rdd3), (Ra12, Rb2, Rcc2, Rdd4), (Ra12, Rb2, Rcc2, Rdd5), (Ra12, Rb2, Rcc2, Rdd6), (Ra12, Rb2, Rcc2, Rdd7), (Ra12, Rb2, Rcc2, Rdd8), (Ra13, Rb1, Rcc1, Rdd1), (Ra13, Rb1, Rcc1, Rdd2), (Ra13, Rb1, Rcc1, Rdd3), (Ra13, Rb1, Rcc1, Rdd4), (Ra13, Rb1, Rcc1, Rdd5), (Ra13, Rb1, Rcc1, Rdd6), (Ra13, Rb1, Rcc1, Rdd7), (Ra13, Rb1, Rcc1, Rdd8), (Ra13, Rb1, Rcc2, Rdd1), (Ra13, Rb1, Rcc2, Rdd2), (Ra13, Rb1, Rcc2, Rdd3), (Ra13, Rb1, Rcc2, Rdd4), (Ra13, Rb1, Rcc2, Rdd5), (Ra13, Rb1, Rcc2, Rdd6), (Ra13, Rb1, Rcc2, Rdd7), (Ra13, Rb1, Rcc2, Rdd8), (Ra13, Rb2, Rcc1, Rdd1), (Ra13, Rb2, Rcc1, Rdd2), (Ra13, Rb2, Rcc1, Rdd3), (Ra13, Rb2, Rcc1, Rdd4), (Ra13, Rb2, Rcc1, Rdd5), (Ra13, Rb2, Rcc1, Rdd6), (Ra13, Rb2, Rcc1, Rdd8), (Ra13, Rb2, Rcc2, Rdd1), (Ra13, Rb2, Rcc2, Rdd2), (Ra13, Rb2, Rcc2, Rdd3), (Ra13, Rb2, Rcc2, Rdd4), (Ra13, Rb2, Rcc2, Rdd5),

(Ra13, Rb2, Rcc2, Rdd6), (Ra13, Rb2, Rcc2, Rdd8), (Ra14, Rb1, Rcc1, Rdd1), (Ra14, Rb1, Rcc1, Rdd2), (Ra14, Rb1, Rcc1, Rdd3), (Ra14, Rb1, Rcc1, Rdd5), (Ra14, Rb1, Rcc1, Rdd6), (Ra14, Rb1, Rcc1, Rdd7), (Ra14, Rb1, Rcc2, Rdd8), (Ra14, Rb1, Rcc2, Rdd2), (Ra14, Rb1, Rcc2, Rdd3), (Ra14, Rb1, Rcc2, Rdd4), (Ra14, Rb1, Rcc2, Rdd5), (Ra14, Rb1, Rcc2, Rdd7), (Ra14, Rb1, Rcc2, Rdd8), (Ra14, Rb2, Rcc1, Rdd1), (Ra14, Rb2, Rcc1, Rdd2), (Ra14, Rb2, Rcc1, Rdd3), (Ra14, Rb2, Rcc1, Rdd5), (Ra14, Rb2, Rcc1, Rdd6), (Ra14, Rb2, Rcc2, 7Rdd7), (Ra14, Rb2, Rcc1, (Rdd1), (Ra14, Rb2, Rcc2, Rdd2), (Ra14, Rb2, Rcc2, Rdd3), (Ra14, Rb2, Rcc2, Rdd4), (Ra14, Rb2, Rcc2, Rdd6), (Ra14, Rb2, Rcc2, Rdd7), (Ra14, Rb2, Rcc2, Rdd8), (Ra15, Rb1, Rcc1, Rdd1), (Ra15, Rb1, Rcc1, Rdd2), (Ra15, Rb1, Rcc1, Rdd3), (Ra15, Rb1, Rcc1, Rdd4), (Ra15, Rb1, Rcc1, Rdd5), (Ra15, Rb1, Rcc1, Rdd6), (Ra15, Rb1, Rcc1, Rdd7), (Ra15, Rb1, Rcc1, Rdd8), (Ra15, Rb1, Rcc2, Rdd1), (Ra15, Rb1, Rcc2, Rdd2), (Ra15, Rb1, Rcc2, Rdd3), (Ra15, Rb1, Rcc2, Rdd4), (Ra15, Rb1, Rcc2, Rdd5), (Ra15, Rb1, Rcc2, Rdd6), (Ra15, Rb1, Rcc2, Rdd7), (Ra15, Rb1, Rcc2, Rdd8), (Ra15, Rb2, Rcc1, Rdd1), (Ra15, Rb2, Rcc1, Rdd2), (Ra15, Rb2, Rcc1, Rdd3), (Ra15, Rb2, Rcc1, Rdd4), (Ra15, Rb2, Rcc1, Rdd5), (Ra15, Rb2, Rcc1, Rdd6), (Ra15, Rb2, Rcc1, Rdd7), (Ra15, Rb2, Rcc1, Rdd8), (Ra15, Rb2, Rcc2, Rdd1), (Ra15, Rb2, Rcc2, Rdd2), (Ra15, Rb2, Rcc2, Rdd3), (Ra15, Rb2, Rcc2, Rdd4), (Ra15, Rb2, Rcc2, Rdd5), (Ra15, Rb2, Rcc2, Rdd6), (Ra15, Rb2, Rcc2, Rdd7), (Ra15, Rb2, Rcc2, Rdd8), (Ra16, Rb1, Rcc1, Rdd1), (Ra16, Rb1, Rcc1, Rdd2) , (Ra16, Rb1, Rcc1, Rdd3), (Ra16, Rb1, Rcc1, 16Rdd4), (Ra16, Rb1,) Rcc1, Rdd5), (Ra16, Rb1, Rcc1, Rdd6), (Ra16, Rb1, Rcc1, Rdd7) , (Ra16, Rb1, Rcc1, Rdd8), (Ra16, Rb1, Rcc2, Rdd1), (Ra16, Rb1, Rcc2, Rdd2), (Ra16, Rb1, Rcc2, Rdd3), (Ra16, Rb1, Rcc2, Rdd4) , (Ra16, Rb1, Rcc2, Rdd5), (Ra16, Rb1, Rcc2, Rdd7), (Ra16, Rb1, Rcc2, Rdd8), (Ra16, Rb2, Rcc1, Rdd1) , (Ra16, Rb2, ccRcc1, Rdd2), (Ra16, Rb2, Rcc1, Rdd3), (Ra16, Rb2, Rcc1, Rdd4), (Ra16, Rb2, Rcc1, Rdd5), (Ra16, Rb2, Rcc1, Rdd6) , (Ra16, Rb2, Rcc1, ddRdd7), (Ra16, Rb2, Rcc1, Rdd8), (Ra16, Rb2, Rcc2, Rdd1), (Ra16, Rb2, Rcc2, Rdd2), (Ra16, Rb2, Rcc2, Rdd3) (Ra16, Rb2, bRcc2, Rdd4), (Ra16, Rb2, Rcc2, Rdd6), (Ra16, Rb2, Rcc2, Rdd7), (Ra16, Rb2, Rcc2, Rdd8) , (Ra17, Rb1, Rcc1, Rdd1), (Ra17, Rb1, Rcc1, Rdd2), (Ra17, Rb1, Rcc1, Rdd3), (Ra17, Rb1, Rcc1, Rdd4), (Ra17, Rb1 , Rcc1, Rdd5), (Ra17, Rb1, Rcc1, Rdd6), (Ra17, Rb1, Rcc1, Rdd8), (Ra17, Rb1, Rcc2, Rdd1), (Ra17, Rb1 , Rcc2, Rdd2), (Ra17, Rb1, Rcc2, Rdd3), (Ra17, Rb1, Rcc2, Rdd5), (Ra17, Rb1, Rcc2, Rdd6), (Ra17, Rb1 , Rcc2, Rdd7), (Ra17, Rb2, Rcc2, Rdd8), (Ra17, Rb2, Rcc1, Rdd1), (Ra17, Rb2, Rcc1, Rdd2), (Ra17, Rb2, Rcc1, Rdd3), (Ra17, Rb2 , Rcc1, Rdd4), (Ra17, Rb2, Rcc1, Rdd6), (Ra17, Rb2, 8Rcc1, Rdd7), (Ra17, Rb2, Rcc1, Rdd8), (Ra17, Rb2 , Rcc2, Rdd1), (Ra17, Rb2, Rcc2, Rdd3), (Ra17, Rb2, Rcc2, Rdd4), (Ra17, Rb2, Rcc2, Rdd5), (Ra17, Rb2) , Rcc2, Rdd6), (Ra17, Rb2, Rcc2, Rdd8), (Ra18, Rb1, Rcc1, Rdd2), (Ra18, Rb1, Rcc1, Rdd2), (Ra18, Rb1) , Rcc1, Rdd3), (Ra18, Rb1, Rcc1, Rdd6), (Ra18, Rb1, Rcc1, Rdd6), (Ra18, Rb1, Rcc1, Rdd7) ), (Ra18, Rb1, Rcc1, Rdd8), (Ra18, Rb1, Rcc2, Rdd1), (Ra18, Rb1, Rcc2, Rdd2), (Ra18, Rb1, Rcc2, Rdd3), (Ra18, Rb1, Rcc2, Rdd4) ), (Ra18, Rb1, Rcc2, Rdd5), (Ra18, Rb1, Rcc2, Rdd6), (Ra18, Rb1, Rcc2, Rdd7), (Ra18, Rb1, Rcc2, Rdd8), (Ra18, Rb2, Rcc1, Rdd1) ), (Ra18, Rb2, Rcc1, Rdd2), (Ra18, Rb2, Rcc1, Rdd3), (Ra18, Rb2, Rcc1, Rdd4), (Ra18, Rb2, Rcc1, Rdd5), (Ra18, Rb2, Rcc1, Rdd6) ), (Ra18, Rb2, Rcc1, Rdd7), (Ra18, Rb2, Rcc1, Rdd8), (Ra18, Rb2, Rcc2, Rdd1), (Ra18, Rb2, Rcc2, Rdd2), (Ra18, Rb2, Rcc2, Rdd3) ), (Ra18, Rb2, Rcc2, Rdd4), (Ra18, Rb2, Rcc2, Rdd5), (Ra18, Rb2, Rcc2, Rdd6), (Ra18, Rb2, Rcc2, Rdd7), (Ra18, Rb2, Rcc2, Rdd8) ), (Ra19, Rb1, Rcc1, Rdd1), (Ra19, RaRb1, Rcc1, Rdd2), (Ra19, Rb1, Rcc1, Rdd3), (Ra19, Rb1, Rcc1, Rdd4), (Ra19, Rb1, Rcc1, Rdd5) ), (Ra19, Rb1, Rcc1, Rdd6), (Ra19, Rb1, Rcc1, Rdd7), (Ra19, Rb1, Rcc1, Rdd8), (Ra19, Rb1, Rcc2, Rdd1), (Ra19, Rb1) 1, Rcc2, Rdd2), (Ra19, Rb1, Rcc2, Rdd3), (Ra19, Rb1, Rcc2, Rdd5), (Ra19, Rb1, Rcc2, Rdd6), (Ra19, Rb1, Rcc2, Rdd7), (Ra19, Rb1, Rcc2, Rdd8), (Ra19, Rb2, Rcc1, Rdd1), (Ra19, Rb2, Rcc1, Rdd2), (Ra19, Rb2, Rcc1, Rdd3), (Ra19, Rb2, Rcc1, Rdd4), (Ra19, Rb2, Rcc1, Rdd6), (Ra19, Rb2, Rcc1, Rdd7), (Ra19, Rb2, Rcc1, Rdd8), (Ra19, Rb2, Rcc2, Rdd1), (Ra19, Rb2, Rcc2, Rdd3), (Ra19, Rb2, Rcc2, Rdd4), (Ra19, Rb2, Rcc2, Rdd5), (Ra19, Rb2, Rcc2, Rdd6), (Ra19, Rb2, Rcc2, Rdd7), (Ra19, Rb2, Rcc2, Rdd8), (Ra20, Rb1, Rcc1, Rdd1), (Ra20, Rb1, Rcc1, Rdd2), (Ra20, Rb1, Rcc1, Rdd3), (Ra20, Rb1, Rcc1, Rdd6), (Ra20, Rb1, Rcc1, Rdd6), (Ra20, Rb1, Rcc1, Rdd7), (Ra20, Rb1, Rcc1, Rdd8), (Ra20, Rb1, Rcc2, Rdd1), (Ra20, Rb1, Rcc2, Rdd2), (Ra20, Rb1, Rcc2, Rdd3), (Ra20, Rb1, Rcc2, Rdd3) 4), (Ra20, Rb1, Rcc2, Rdd5), (Ra20, Rb1, Rcc2, Rdd6), (Ra20, Rb1, Rcc2, Rdd7), (Ra20, Rb1, Rcc2, Rdd8), (Ra20, Rb2, Rcc1, Rdd1), (Ra20, Rb2, Rcc1, Rdd2), (Ra20, Rb2, Rcc1, Rdd3), (Ra20, Rb2, Rcc1, Rdd4), (Ra20, Rb2, Rcc1, Rdd5), (Ra20, Rb2, Rcc1, Rdd6), (Ra20, Rb2, Rcc1, Rdd7), (Ra20, Rb2, Rcc1, Rdd8), (Ra20, Rb2, Rcc2, Rdd1), (Ra20, Rb2, Rcc2, Rdd2), (Ra20, Rb2, Rcc2, Rdd3), (Ra20, Rb2, Rcc2, Rdd4), (Ra20, Rb2, Rcc2, Rdd5), (Ra20, Rb2, Rcc2, Rdd6), (Ra20, Rb2, Rcc2, Rdd7), (Ra20, Rb2, Rcc2, Rdd8), (Ra21, Rb1, Rcc1, Rdd1), (Ra21, Rb1, Rcc1, Rdd2), (Ra21, Rb1, Rcc1, Rdd3), (Ra21, Rb1, Rcc1, Rdd4), (Ra21, Rb1, Rcc1, Rdd5), (Ra21, Rb1, Rcc1, Rdd6), (Ra21, Rb1, Rcc1, Rdd7), (Ra21, Rb1, Rcc1, Rdd8), (Ra21, Rb1, Rcc2, Rdd1), (Ra21, Rb1, Rcc2, Rdd2), (Ra21, Rb1, Rcc2, Rdd3), (Ra21, Rb1, Rcc2, Rdd4), (Ra21, Rb1, Rcc2, Rdd5), (Ra21, Rb1, Rcc2, Rdd6), (Ra21, R b1, Rcc2, Rdd7), (Ra21, Rb1, Rcc2, Rdd8), (Ra21, Rb2, Rcc1, Rdd1), (Ra21, Rb2, Rcc1, Rdd2), (Ra21, Rb2, Rcc1, Rdd3), (Ra21, Rb2, Rcc1, Rdd4), (Ra21, Rb2, Rcc1, Rdd6), (Ra21, Rb2, Rcc1, Rdd7), (Ra21, Rb2, Rcc1, Rdd8), (Ra21, Rb2, Rcc2, Rdd1), (Ra21, Rb2, Rcc2, Rdd3), (Ra21, Rb2, Rcc2, Rdd4), (Ra21, Rb2, Rcc2, Rdd5), (Ra21, Rb2, Rcc2, Rdd6), (Ra21, Rb2, Rcc2, Rdd1), (Ra22, Rb1, Rcc1, Rdd1), (Ra22, Rb1, Rcc1, Rdd2), (Ra22, Rb1, Rcc1, Rdd3), (Ra22, Rb1, Rcc1, Rdd6), (Ra22, Rb1, Rcc1, Rdd6), (Ra22, Rb1, Rcc1, Rdd7), (Ra22, (Rb1, Rcc1, Rdd8), (Ra22, Rb1, Rcc2, Rdd2), (Ra22, Rb1, Rcc2, Rdd3), (Ra22, Rb1, Rcc2, Rdd4), (Ra22, Rb1, Rcc2, Rdd5), (Ra22, Rb1, Rcc2, Rdd6), (Ra22, Rb1, Rcc2, Rdd7), (Ra22, Rb1, Rcc2, Rdd8), (Ra22, Rb2, Rcc1, Rd d1), (Ra22, Rb2, Rcc1, Rdd2), (Ra22, Rb2, Rcc1, Rdd3), (Ra22, Rb2, Rcc1, Rdd4), (Ra22, Rb2, Rcc1, Rdd5), (Ra22, Rb2, Rcc1, Rdd6), (Ra22, Rb2, Rcc1, Rdd7), (Ra22, Rb2, Rcc1, Rdd8), (Ra22, Rb2, Rcc2, Rdd1), (Ra22, Rb2, Rcc2, Rdd2), (Ra22, Rb2, Rcc2, Rdd3), (Ra22, Rb2, Rcc2, Rdd4), (Ra22, Rb2, Rcc2, Rdd5), (Ra22, Rb2, Rcc2, Rdd6), (Ra22, Rb2, Rcc2, Rdd7), (Ra22, Rb2, Rcc2, Rdd8), (Ra23, Rb1, Rcc1, Rdd1), (Ra23, Rb1, Rcc1, Rdd2), (Ra23, Rb1, Rcc1, Rdd3), (Ra23, Rb1, Rcc1, Rdd4), (Ra23, Rb1, Rcc1, Rdd5), (Ra23, Rb1, Rcc1, Rdd6), (Ra23, Rb1, Rcc1, Rdd7), (Ra23, Rb1, Rcc1, Rdd8), (Ra23, Rb1, Rcc2, Rdd1), (Ra23, Rb1, Rcc2, Rdd2), (Ra23, Rb1, Rcc2, Rdd3), (Ra23, Rb1, Rcc2, Rdd4), (Ra23, Rb1, Rcc2, Rdd5), (Ra23, Rb1, Rcc2, Rdd6), (Ra23, Rb1, Rcc2, Rdd7), (Ra23, Rb1, Rcc2, Rdd8), (Ra23, Rb2, Rcc1, Rdd1), (Ra23, Rb2, Rcc1, Rdd2), (Ra23, Rb2, Rcc1, Rdd3), (Ra23, Rb2, Rcc1, Rdd4), (Ra23, Rb2, Rcc1, Rdd5), (Ra23, Rb2, Rcc1, Rdd6), (Ra23, Rb2, Rcc1, Rdd7), (Ra23, Rb2, Rcc1, Rdd8), (Ra23, Rb2, Rcc2, Rdd1), (Ra23, Rb2, Rcc2, Rdd4), (Ra23, Rb2, Rcc2, Rdd4), (Ra23, Rb2, Rcc2, Rdd5), (Ra23, Rb2, Rcc2, Rdd6), (Ra23, Rb2, Rcc2, Rdd7), (Ra23, Rb2, Rcc2, Rdd8), (Ra24, Rb1, Rcc1, Rdd1), (Ra24, Rb1, Rcc1, Rdd2), (Ra24, Rb1, Rcc1, Rdd3), (Ra24, Rb1, Rcc1, Rdd4), (Ra24, Rb1, Rcc1, Rdd5), (Ra24, Rb1, Rcc1, Rdd6), (Ra24, Rb1, Rcc1, Rdd7), (Ra24, Rb1, Rcc1, Rdd8), (Ra24, Rb1, Rcc2, Rdd1), (Ra24, Rb1, Rcc2, Rdd2), (Ra24, Rb1, Rcc2, Rdd3), (Ra24, Rb1, Rcc2, Rdd4), (Ra24, Rb1, Rcc2, Rdd5), (Ra24, Rb1, Rcc2, Rdd6), (Ra24, Rb1, Rcc2, Rdd7), (Ra24, Rb1, Rcc2, Rdd8), (Ra24, Rb2, Rcc1, Rdd1), (Ra24, Rb2, Rcc1, Rdd2), (Ra24, Rb2, Rcc1, Rdd3), (Ra24, Rb2, Rcc1, Rdd4), (Ra24, Rb2, Rcc1, Rdd5), (Ra24, Rb2, Rcc1, R dd6), (Ra24, Rb2, Rcc1, Rdd7), (Ra24, Rb2, Rcc1, Rdd8), (Ra24, Rb2, Rcc2, Rdd1), (Ra24, Rb2, Rcc2, Rdd2), (Ra24, Rb2, Rcc2, Rdd3), (Ra24, Rb2, Rcc2, Rdd4), (Ra24, Rb2, Rcc2, Rdd5), (Ra24, Rb2, Rcc2, Rdd6), (Ra24, Rb2, Rcc2, Rdd7), (Ra24, Rb2, Rcc2, Rdd8), (Ra25, Rb1, Rcc1, Rdd1), (Ra25, Rb1, Rcc1, Rdd2), (Ra25, Rb1, Rcc1, Rdd3), (Ra25, Rb1, Rcc1, Rdd4), (Ra25, Rb1, Rcc1, Rdd5), (Ra25, Rb1, Rcc1, Rdd6), (Ra25, Rb1, Rcc1, Rdd7), (Ra25, Rb1, Rcc1, Rdd8), (Ra25, Rb1, Rcc2, Rdd1), (Ra25, Rb1, Rcc2, Rdd2), (Ra25, Rb1, Rcc2, Rdd3), (Ra25, Rb1, Rcc2, Rdd4), (Ra25, Rb1, Rcc2, Rdd5), (Ra25, Rb1, Rcc2, Rdd6), (Ra25, Rb1, Rcc2, Rdd7), (Ra25, Rb1, Rcc2, Rdd8), (Ra25, Rb2, Rcc1, Rdd1), (Ra25, Rb2, Rcc1, Rdd2), (Ra25, Rb2, Rcc1, Rdd3), (Ra25, Rb2, Rcc1, Rdd4), (Ra25, Rb2, Rcc1, Rdd5), (Ra25, Rb2, Rcc1, Rdd6), (Ra25, Rb2, Rcc1, Rdd7),

(Ra25, Rb2, Rcc2, Rdd4), (Ra25, Rb2, Rcc2, Rdd2), (Ra25, Rb2, Rcc2, Rdd3), (Ra25, Rb2, Rcc2, Rdd4), (Ra25, Rb2, Rcc2, Rdd5), (Ra25, Rb2, Rcc2, Rdd7), (Ra25, Rb2, Rcc2, Rdd8), (Ra26, Rb1, Rcc1, Rdd1), (Ra26, Rb1, Rcc1, Rdd2), (Ra26, Rb1, Rcc1, Rdd4), (Ra26, Rb1, Rcc1, Rdd5), (Ra26, Rb1, Rcc1, Rdd6), (Ra26, Rb1, Rcc1, Rdd7), (Ra26, Rb1, Rcc2, (Rdd1), (Ra26, Rb1, Rcc2, Rdd2), (Ra26, Rb1, Rcc2, Rdd3), (Ra26, Rb1, Rcc2, Rdd4), (Ra26, Rb1, Rcc2, Rdd6), (Ra26, Rb1, Rcc2, Rdd7), (Ra26, Rb1, Rcc2, Rdd8), (Ra26, Rb2, Rcc1, Rdd1), (Ra26, Rb2, Rcc1, Rdd3), (Ra26, Rb2, Rcc1, Rdd4), (Ra26, Rb2, Rcc1, Rdd5), (Ra26, Rb2, Rcc1, Rdd6), (Ra26, Rb2, Rcc1, Rdd8), (Ra26, Rb2, Rcc2, Rdd1), (Ra26, Rb2, Rcc2, Rdd2), (Ra26, Rb2, Rcc2, Rdd3), (Ra26, Rb2, Rcc2, Rdd5), (Ra26, Rb2, Rcc2, Rdd6), (Ra26, Rb2, Rcc2, Rdd7), (Ra26, Rb2, Rcc2, Rdd8), (Ra27, Rb1, Rcc1, Rdd1), (Ra27, Rb1, Rcc1, Rdd2), (Ra27, Rb1, Rcc1, Rdd3), (Ra27, Rb1, Rcc1, Rdd4), (Ra27, Rb1, Rcc1, Rdd5), (Ra27, Rb1, Rcc1, Rdd6), (Ra27, Rb1, Rcc1, Rdd7), (Ra27, Rb1, Rcc1, Rdd8), (Ra27, Rb1, Rcc2, Rdd1), (Ra27, Rb1, Rcc2, Rdd2), (Ra27, Rb1, Rcc2, Rdd3), (Ra27, Rb1, Rcc2, Rdd4), (Ra27, Rb1, Rcc2, Rdd5), (Ra27, Rb1, Rcc2, Rdd6), (Ra27, Rb1, Rcc2, Rdd7), (Ra27, Rb1, Rcc2, Rdd8), (Ra27, Rb2, Rcc1, Rdd1), (Ra27, Rb2, Rcc1, Rdd2), (Ra27, Rb2, Rcc1, Rdd3), (Ra27, Rb2, Rcc1, Rdd4), (Ra27, Rb2, Rcc1, Rdd5), (Ra27, Rb2, Rcc1, Rdd6), (Ra27, Rb2, Rcc1, Rdd7), (Ra27, Rb2, Rcc1, Rdd8), (Ra27, Rb2, Rcc2, Rdd1), (Ra27, Rb2, Rcc2, Rdd2), (Ra27, Rb2, Rcc2, Rdd3), (Ra27, Rb2, Rcc2, Rdd4) , (Ra27, Rb2, ddRcc2, Rdd5), (Ra27, Rb2, Rcc2, Rdd6), (Ra27, Rb2, Rcc2, Rdd7), (Ra27, Rb2, Rcc2, Rdd8).

In the compound represented by the formula (IB), examples of the combination of Ra, Rb and Re include the following.
(Ra, Rb, Re) = (Ra1, Rb1, Re1), (Ra1, Rb1, Re2), (Ra1, Rb1, Re3), (Ra1, Rb1, Re4), (Ra1, Rb1, Re5), (Ra1 , Rb1, Re6), (Ra1, Rb1, Re7), (Ra1, Rb1, Re8), (Ra1, Rb1, Re9), (Ra1, Rb1, Re10), (Ra1, Rb1, Re11), (Ra1, Rb1 , Re12), (Ra1, Rb1, Re13), (Ra1, Rb2, Re1), (Ra1, Rb2, Re2), (Ra1, Rb2, Re3), (Ra1, Rb2, Re4), (Ra1, Rb2, Re5) ), (Ra1, Rb2, Re6), (Ra1, Rb2, Re7), (Ra1, Rb2, Re8), (Ra1, Rb2, Re9), (Ra1, Rb2, Re10), (Ra1, Rb2, Re11), (Ra1, Rb2, Re12), (Ra1, Rb2, Re13), (Ra2, Rb1, Re1), (Ra2, Rb1, Re2), (Ra2, Rb1, Re3), (Ra2, Rb1, Re4), (Ra2 , Rb1, Re5), (Ra2, Rb1, Re6), (Ra2, Rb1, Re7), (Ra2, Rb1, Re8), (Ra2, Rb1, Re9), (Ra2, Rb1, Re10), (Ra2, Rb1 , Re11), (Ra2, Rb1, Re12), (Ra2, Rb1, Re13), (Ra2, Rb2, Re1), (Ra2, Rb2, Re2), (Ra2, Rb2, Re3), (Ra2, Rb2, Re4) ), (Ra2, Rb2, Re5), (Ra2, Rb2, Re6), (Ra2, Rb2, Re7), (Ra2, Rb2, Re8), (Ra2, Rb2, Re9), (Ra2, Rb2, Re10), (Ra2, Rb2, Re11), (Ra2, Rb2, Re12), (Ra2, Rb2, Re13), (Ra3, Rb1, Re1) , (Ra3, Rb1, Re2), (Ra3, Rb1, Re3), (Ra3, Rb1, Re4), (Ra3, Rb1, Re5), (Ra3, Rb1, Re6), (Ra3, Rb1, Re7), ( (Ra3, Rb1, Re8), (Ra3, Rb1, Re9), (Ra3, Rb1, Re10), (Ra3, Rb1, Re11), (Ra3, Rb1, Re12), (Ra3, Rb1, Re13), (Ra3, Rb2, Re1), (Ra3, Rb2, Re2), (Ra3, Rb2, Re3), (Ra3, Rb2, Re4), (Ra3, Rb2, Re5), (Ra3, Rb2, Re6), (Ra3, Rb2, (Re7), (Ra3, Rb2, Re8), (Ra3, Rb2, Re9), (Ra3, Rb2, Re10), (Ra3, Rb2, Re11), (Ra3, Rb2, Re12), (Ra3, Rb2, Re13) , (Ra4, Rb1, Re1), (Ra4, Rb1, Re2), (Ra4, Rb1, Re3), (Ra4, Rb1, Re4), (Ra4, Rb1, Re5), (Ra4, Rb1, Re6), ( (Ra4, Rb1, Re7), (Ra4, Rb1, Re8), (Ra4, Rb1, Re9), (Ra4, Rb1, Re10), (Ra4, Rb1, Re11), (Ra4, Rb1, Re12), (Ra4, Rb1, Re13), (Ra4, Rb2, Re1), (Ra4, Rb2, Re2), (Ra4, Rb2, Re3), (Ra4, Rb2, Re4), (Ra4, Rb2, Re5), (Ra4, Rb2, (Re6), (Ra4, Rb2, Re7), (Ra4, Rb2, Re8), (Ra4, Rb2, Re9), (Ra4, Rb2, Re10), (Ra4, Rb2, Re11), (Ra4, Rb2, Re12) , (Ra4, Rb2, Re13), (Ra5, Rb1, Re1), (Ra5, Rb1, Re2), (Ra5, Rb1, Re3), (Ra5, Rb1 , Re4), (Ra5, Rb1, Re5), (Ra5, Rb1, Re6), (Ra5, Rb1, Re7), (Ra5, Rb1, Re8), (Ra5, Rb1, Re9), (Ra5, Rb1, Re10) ), (Ra5, Rb1, Re11), (Ra5, Rb1, Re12), (Ra5, Rb1, Re13), (Ra5, Rb2, Re1), (Ra5, Rb2, Re2), (Ra5, Rb2, Re3), (Ra5, Rb2, Re4), (Ra5, Rb2, Re5), (Ra5, Rb2, Re6), (Ra5, Rb2, Re7), (Ra5, Rb2, Re8), (Ra5, Rb2, Re9), (Ra5 , Rb2, Re10), (Ra5, Rb2, Re11), (Ra5, Rb2, Re12), (Ra5, Rb2, Re13), (Ra6, Rb1, Re1), (Ra6, Rb1, Re2), (Ra6, Rb1 , Re3), (Ra6, Rb1, Re4), (Ra6, Rb1, Re5), (Ra6, Rb1, Re6), (Ra6, Rb1, Re7), (Ra6, Rb1, Re8), (Ra6, Rb1, Re9) ), (Ra6, Rb1, Re10), (Ra6, Rb1, Re11), (Ra6, Rb1, Re12), (Ra6, Rb1, Re13), (Ra6, Rb2, Re1), (Ra6, Rb2, Re2), (Ra6, Rb2, Re3), (Ra6, Rb2, Re4), (Ra6, Rb2, Re5), (Ra6, Rb2, Re6), (Ra6, Rb2, Re7), (Ra6, Rb2, Re8), (Ra6 , Rb2, Re9), (Ra6, Rb2, Re10), (Ra6, Rb2, Re11), (Ra6, Rb2, Re12), (Ra6, Rb2, Re13), (Ra7, Rb1, Re1), (Ra7, Rb1 , Re2), (Ra7, Rb1, Re3), (Ra7, Rb1, Re4), (Ra7, Rb1, Re5), (Ra7, Rb1, Re6), (Ra 7, Rb1, Re7), (Ra7, Rb1, Re8), (Ra7, Rb1, Re9), (Ra7, Rb1, Re10), (Ra7, Rb1, Re11), (Ra7, Rb1, Re12),

(Ra7, Rb1, Re13), (Ra7, Rb2, Re1), (Ra7, Rb2, Re2), (Ra7, Rb2, Re3), (Ra7, Rb2, Re4), (Ra7, Rb2, Re5), (Ra7 , Rb2, Re6), (Ra7, Rb2, Re7), (Ra7, Rb2, Re8), (Ra7, Rb2, Re9), (Ra7, Rb2, Re10), (Ra7, Rb2, Re11), (Ra7, Rb2 , Re12), (Ra7, Rb2, Re13), (Ra8, Rb1, Re1), (Ra8, Rb1, Re2), (Ra8, Rb1, Re3), (Ra8, Rb1, Re4), (Ra8, Rb1, Re5 ), (Ra8, Rb1, Re6), (Ra8, Rb1, Re7), (Ra8, Rb1, Re8), (Ra8, Rb1, Re9), (Ra8, Rb1, Re10), (Ra8, Rb1, Re11), (Ra8, Rb1, Re12), (Ra8, Rb1, Re13), (Ra8, Rb2, Re1), (Ra8, Rb2, Re2), (Ra8, Rb2, Re3), (Ra8, Rb2, Re4), (Ra8 , Rb2, Re5), (Ra8, Rb2, Re6), (Ra8, Rb2, Re7), (Ra8, Rb2, Re8), (Ra8, Rb2, Re9), (Ra8, Rb2, Re10), (Ra8, Rb2 , Re11), (Ra8, Rb2, Re12), (Ra8, RaRb2, Re13), (Ra9, Rb1, Re1), (Ra9, Rb1, Re2), (Ra9, Rb1, Re3), (Ra9, Rb1, Re4) ), (Ra9, Rb1, Re5), (Ra9, Rb1, Re6), (Ra9, Rb1, Re7), (Ra9, Rb1, Re8), (Ra9, Rb1, Re9), (Ra9, Rb1, Re10), (Ra9, Rb1, Re11), (Ra9, Rb1, Re12), (Ra9, Rb1, Re13), (Ra9, Rb2, Re1), (Ra9, Rb2, Re2), (Ra9, Rb2, (Re3), (Ra9, Rb2, Re4), (Ra9, Rb2, Re5), (Ra9, Rb2, Re6), (Ra9, Rb2, Re7), (Ra9, Rb2, Re8), (Ra9, Rb2, Re9) , (Ra9, Rb2, Re10), (Ra9, Rb2, Re11), (Ra9, Rb2, Re12), (Ra9, Rb2, Re13), (Ra10, Rb1, Re1), (Ra10, Rb1, Re2), ( (Ra10, Rb1, Re3), (Ra10, Rb1, Re4), (Ra10, Rb1, Re5), (Ra10, Rb1, Re6), (Ra10, Rb1, Re7), (Ra10, Rb1, Re8), (Ra10, Rb1, Re9), (Ra10, Rb1, Re10), (Ra10, Rb1, Re11), (Ra10, Rb1, Re12), (Ra10, Rb1, Re13), (Ra10, Rb2, Re1), (Ra10, Rb2, (Re2), (Ra10, Rb2, Re3), (Ra10, Rb2, Re4), (Ra10, Rb2, Re5), (Ra10, Rb2, Re6), (Ra10, Rb2, Re7), (Ra10, Rb2, Re8) , (Ra10, Rb2, Re9), (Ra10, Rb2, Re10), (Ra10, Rb2, Re11), (Ra10, Rb2, Re12), (Ra10, Rb2, Re13), (Ra11, Rb1, Re1), ( Ra11, Rb1, Re2), (Ra11, Rb1, Re3), (Ra11, Rb1, Re4), (Ra11, Rb1, Re5), (Ra11, Rb1, Re7), (Ra11, Rb1, Re8), (Ra11, Rb1, Re9), (Ra11, Rb1, Re10), (Ra11, Rb1, Re11), (Ra11 , Rb1, Re12), (Ra11, Rb1, Re13), (Ra11, Rb2, Re1), (Ra11, Rb2, Re2), (Ra11, Rb2, Re3), (Ra11, Rb2, Re4), (Ra11, Rb2 , Re5), (Ra11, Rb2, Re6), (Ra11, Rb2, Re7), (Ra11, Rb2, Re8), (Ra11, Rb2, Re9), (Ra11, Rb2, Re10), (Ra11, Rb2, Re11 ), (Ra11, Rb2, Re12), (Ra11, Rb2, Re13), (Ra12, Rb1, Re1), (Ra12, Rb1, Re2), (Ra12, Rb1, Re3), (Ra12, Rb1, Re4), (Ra12, Rb1, Re5), (Ra12, Rb1, Re6), (Ra12, Rb1, Re7), (Ra12,) Rb1, Re8), (Ra12, Rb1, Re9), (Ra12, Rb1, Re10), (Ra12 , Rb1, Re11), (Ra12, Rb1, Re12), (Ra12, Rb1, Re13), (Ra12, Rb2, Re1), (Ra12, Rb2, Re2), (Ra12, Rb2, Re3), (Ra12, Rb2 , Re4), (Ra12, Rb2, Re5), (Ra12, Rb2, Re6), (Ra12, Rb2, Re7), (Ra12, Rb2, Re8), (Ra12, Rb2, Re9), (Ra12, Rb2, Re10) ), (Ra12, Rb2, Re11), (Ra12, Rb2, Re12), (Ra12, Rb2, Re13) , (Ra13, Rb1, Re1), (Ra13, Rb1, Re3), (Ra13, Rb1, Re4), (Ra13, Rb1, Re5), (Ra13, Rb1, Re6), ( (Ra13, Rb1, Re7), (Ra13, Rb1, Re8), (Ra13, Rb1, Re9), (Ra13, Rb1, Re10), (Ra13, Rb1, Re11), (Ra13, Rb1, Re12), (Ra13, Rb1, Re13), (Ra13, Rb2, Re1), (Ra13, Rb2, Re2), (Ra13, Rb2, Re3), (Ra13, Rb2, Re4), (Ra13, Rb2, Re5), (Ra13, Rb2, (Re6), (Ra13, Rb2, Re7), (Ra13, Rb2, Re8), (Ra13, Rb2, Re9), (Ra13, Rb2, Re10), (Ra13, Rb2, Re11), (Ra13, Rb2, Re12) , (Ra13, Rb2, Re13), (Ra14, Rb1, Re1), (Ra14, Rb1, Re2), (Ra14, Rb1, Re3), (Ra14, Rb1, Re4), (Ra14, Rb1, Re5), ( (Ra14, Rb1, Re6), (Ra14, Rb1, Re7), (Ra14, Rb1, Re8), (Ra14, Rb1, Re9), (Ra14, Rb1, Re10), (Ra14, Rb1, Re11), (Ra14, Rb1, Re12),

(Ra14, Rb1, Re13), (Ra14, Rb2, Re1), (Ra14, Rb2, Re2), (Ra14, Rb2, Re3), (Ra14, Rb2, Re4), (Ra14, Rb2, Re5), (Ra14 , Rb2, Re6), (Ra14, Rb2, Re7), (Ra14, Rb2, Re8), (Ra14, Rb2, Re9), (Ra14, Rb2, Re10), (Ra14, Rb2, Re11), (Ra14, Rb2 , Re12), (Ra14, b Rb2, Re13), (Ra15, Rb1, Re1), (Ra15, Rb1, Re2), (Ra15, Rb1, Re3), (Ra15, Rb1, Re4), (Ra15, Rb1, Re5 ), (Ra15, Rb1, Re6), (Ra15, Rb1, Re7), (Ra15, Rb1, Re8), (Ra15, Rb1, Re9), (Ra15, Rb1, Re10), (Ra15, Rb1, Re11), (Ra15, Rb1, Re12), (Ra15, Rb1, Re13), (Ra15, Rb2, Re1), (Ra15, Rb2, Re2), (Ra15, Rb2, Re3), (Ra15, Rb2, Re4), (Ra15 , Rb2, Re5), (Ra15, Rb2, Re6), (Ra15, Rb2, Re7), (Ra15, Rb2, Re8), (Ra15, Rb2, Re9), (Ra15, Rb2, Re10), (Ra15, Rb2 , Re11), (Ra15, Rb2, Re12), (Ra15, Rb2, Re13), (Ra16, Rb1, Re1), (Ra16, Rb1, Re2), (Ra16, Rb1, Re3), (Ra16, Rb1, Re4) ), (Ra16, Rb1, Re5), (Ra16, Rb1, Re6), (Ra16, Rb1, Re7), (Ra16, Rb1, Re8), (Ra16, Rb1, Re10), (Ra16, Rb1, Re11), (Ra16, Rb1, Re12), (Ra16, Rb1, Re13), (Ra16 , Rb2, Re1), (Ra16, Rb2, Re2), (Ra16, Rb2, Re3), (Ra16, Rb2, Re4), (Ra16, Rb2, Re5), (Ra16, Rb2, Re6), (Ra16, Rb2 , Re7), (Ra16, Rb2, Re8), (Ra16, Rb2, Re9), (Ra16, Rb2, Re10), (Ra16, Rb2, Re11), (Ra16, Rb2, Re12), (Ra16, Rb2, Re13 ), (Ra17, Rb1, Re1), (Ra17, Rb1, Re2), (Ra17, Rb1, Re3), (Ra17, Rb1, Re4), (Ra17, Rb1, Re5), (Ra17, Rb1, Re6), (Ra17, Rb1, Re7), (Ra17, Rb1, Re8), (Ra17, Rb1, Re9), (Ra17, Rb1, Re10), (Ra17, Rb1, Re11), (Ra17, Rb1, Re12), (Ra17 , Rb1, Re13), (Ra17, Rb2, Re1), (Ra17, Rb2, Re2), (Ra17, Rb2, Re3), (Ra17, Rb2, Re4), (Ra17, Rb2, Re5), (Ra17, Rb2 , Re6), (Ra17, Rb2, Re7), (Ra17, Rb2, Re8), (Ra17, Rb2, Re9), (Ra17, Rb2, Re10), (Ra17, Rb2, Re11), (Ra17, Rb2, Re12 ), (Ra17, Rb2, Re13), (Ra18, Rb1, Re1), (Ra18, Rb1, Re2) , (Ra18, Rb1, Re3), (Ra18, Rb1, Re5), (Ra18, Rb1, Re6), (Ra18, Rb1, Re7), (Ra18, Rb1, Re8), ( (Ra18, Rb1, 9Re9), (Ra18, Rb1, Re10), (Ra18, Rb1, Re11), (Ra18, Rb1, Re12), (Ra18, Rb1, Re13), (Ra18, Rb2, Re1), (Ra18, Rb2, Re2), (Ra18, Rb2, Re3), (Ra18, Rb2, Re4), (Ra18, Rb2, Re5), (Ra18, Rb2, Re6), (Ra18, Rb2, Re7), (Ra18, Rb2, (Re8), (Ra18, Rb2, Re9), (Ra18, Rb2, Re10), (Ra18, Rb2, Re11), (Ra18, Rb2, Re12), (Ra18, Rb2, Re13), (Ra19, Rb1, Re1) , (Ra19, Rb1, 2 Re2), (Ra19, Rb1, Re4), (Ra19, Rb1, Re5), (Ra19, Rb1, Re6), (Ra19, Rb1, Re7), ( (Ra19, Rb1, Re9), (Ra19, Rb1, Re10), (Ra19, Rb1, Re11), (Ra19, Rb1, Re12), (Ra19, Rb1, Re13), (Ra19, Rb2, Re1), (Ra19, Rb2, Re2), (Ra19, Rb2, Re3), (Ra19, Rb2, Re4), (Ra19, Rb2, Re5), (Ra19, Rb2, Re6), (Ra19, Rb2, Re7), (Ra19, Rb2, Re8), (Ra19, Rb2, Re9), (Ra19, Rb2, Re10) , (Ra19, Rb2, Re11), (Ra19, Rb2, Re12), (Ra19, Rb2, Re13), (Ra20, Rb1, Re1), (Ra20, Rb1, Re2), (Ra20, Rb1, Re3), ( (Ra20, Rb1, Re4), (Ra20, Rb1, Re5), (Ra20, Rb1, Re6), (Ra20, Rb1, Re7), (Ra20, Rb1, Re8), (Ra20, Rb1, Re9), (Ra20, Rb1, Re10), (Ra20, Rb1, Re11), (Ra20, Rb1, Re12), (Ra20, Rb1, Re13), (Ra20, Rb2, Re1), (Ra20, Rb2, Re2), (Ra20, Rb2, (Re3), (Ra20, Rb2, Re4), (Ra20, Rb2, Re5), (Ra20, Rb2, Re6), (Ra20, Rb2, Re7), (Ra20, Rb2, Re8), (Ra20, Rb2, Re9) , (Ra20, Rb2, Re10), (Ra20, Rb2, Re11), (Ra20, Rb2, Re12), (Ra20, Rb2, Re13), (Ra21, Rb1, Re1), (Ra21, Rb1, Re2), ( (Ra21, Rb1, Re3), (Ra21, Rb1, Re4), (Ra21, Rb1, Re5), (Ra21, Rb1, Re6), (Ra21, Rb1, Re7), (Ra21, Rb1, Re8), (Ra21, Rb1, Re9), (Ra21, Rb1, Re10), (Ra21, Rb1, Re11), (Ra21, Rb1, Re12), (Ra21, Rb1, Re13), (Ra21, Rb2, Re1), (Ra21, Rb2, Re2), (Ra21, Rb2, Re3), (Ra21, Rb2, Re4), (Ra21, Rb2, Re 5), (Ra21, Rb2, Re6), (Ra21, Rb2, Re7), (Ra21, Rb2, Re8), (Ra21, Rb2, Re9), (Ra21, Rb2, Re10), (Ra21, Rb2, Re11) , (Ra21, Rb2, Re12), (Ra21, Rb2, Re13), (Ra22, Rb1, Re1), (Ra22, Rb1, Re2), (Ra22, Rb1, Re3), (Ra22, Rb1, Re4), ( (Ra22, Rb1, Re5), (Ra22, Rb1, Re7), (Ra22, Rb1, Re8), (Ra22, Rb1, Re9), (Ra22, Rb1, Re10), (Ra22, Rb1, Re11), (Ra22, Rb1, Re12), (Ra22, Rb1, Re13), (Ra22, Rb2, Re1), (Ra22, Rb2, Re2), (Ra22, Rb2, Re3), (Ra22, Rb2, (Re4), (Ra22, Rb2, Re5), (Ra22, Rb2, Re6), (Ra22, Rb2, Re7), (Ra22, Rb2, Re8), (Ra22, Rb2, Re9), (Ra22, Rb2, Re10) , (Ra22, Rb2, Re11), (Ra22, Rb2, Re12), (Ra22, Rb2, Re13), (Ra23, Rb1, Re1),

(Ra23, Rb1, Re2), (Ra23, Rb1, Re3), (Ra23, Rb1, Re4), (Ra23, Rb1, Re5), (Ra23, Rb1, Re6), (Ra23, Rb1, Re7), (Ra23 , Rb1, Re8), (Ra23, Rb1, Re9), (Ra23, Rb1, Re10), (Ra23, Rb1,23Re11), (Ra23, Rb1, Re12), (Ra23, Rb1, Re13), (Ra23, Rb2 , Re1), (Ra23, b Rb2,) Re2), (Ra23, Rb2, Re3), (Ra23, Rb2, Re4), (Ra23, Rb2, Re5), (Ra23, Rb2, Re6), (Ra23, Rb2, Re7 ), (Ra23, Rb2, Re8), (Ra23, Rb2, Re9), (Ra23, Rb2, Re10), (Ra23, Rb2, Re11), (Ra23, Rb2, Re12), (Ra23, Rb2, Re13), (Ra24, Rb1, Re1), (Ra24, Rb1, Re2), (Ra24, Rb1, Re3), (Ra24, Rb1, Re4), (Ra24, Rb1, (Re5), (Ra24, Rb1, Re6), (Ra24 , Rb1, Re7), (Ra24, Rb1, Re8), (Ra24, Rb1, Re9), (Ra24, Rb1, Re10), (Ra24, Rb1, Re11), (Ra24, Rb1, Re12), (Ra24, Rb1 , Re13), (Ra24, Rb2, Re1), (Ra24, Rb2, Re2), (Ra24, Rb2, Re3), (Ra24, Rb2, Re4), (Ra24, Rb2, Re5), (Ra24, Rb2, Re6) ), (Ra24, Rb2, Re7), (Ra24, Rb2, Re8), (Ra24, Rb2, Re9) (Ra24, Rb2, Re10), (Ra24, Rb2, Re11), (Ra24, Rb2, Re12), (Ra24, Rb2, Re13), (Ra25, Rb1, Re1), (Ra25, Rb1, Re2), (Ra25 , Rb1, Re3), (Ra25, Rb1, Re4), (Ra25, Rb1, Re5), (Ra25, Rb1, Re6), (Ra25, Rb1, Re7), (Ra25, Rb1, Re8), (Ra25, Rb1 , Re9), (Ra25, Rb1, Re10), (Ra25, Rb1, Re11), (Ra25, Rb1, Re12), (Ra25, Rb1, Re13), (Ra25, Rb2, Re1), (Ra25, Rb2, Re2 ), (Ra25, Rb2, Re3), (Ra25, Rb2, Re4), (Ra25, Rb2, Re5), (Ra25, Rb2, Re6), (Ra25, Rb2, Re7), (Ra25, Rb2, Re8), (Ra25, Rb2, Re9), (Ra25, Rb2, Re10), (Ra25, Rb2, Re11), (Ra25, Rb2, Re12), (Ra25, (Rb2, Re13), (Ra26, Rb1, Re1), (Ra26 , Rb1, Re2), (Ra26, Rb1, Re3), (Ra26, Rb1, Re4), (Ra26, Rb1, Re5), (Ra26, Rb1, Re6), (Ra26, Rb1, Re7), (Ra26, Rb1 , Re8), (Ra26, Rb1, Re9), (Ra26, Rb1, Re10), (Ra26, Rb1, Re11), (Ra26, Rb1, Re12), (Ra26, Rb1, Re13), (Ra26, Rb2, Re1 ), (Ra26, Rb2, Re2), (Ra26, Rb2, Re3), (Ra26, Rb2, Re4) ), (Ra26, Rb2, Re5), (Ra26, Rb2, Re6), (Ra26, Rb2, Re7), (Ra26, Rb2, Re8), (Ra26, Rb2, Re9), (Ra26, Rb2, Re10), (Ra26, Rb2, Re11), (Ra26, Rb2, Re12), (Ra26, Rb2, Re13), (Ra27, Rb1, Re1), (Ra27, Rb1, Re2), (Ra27, Rb1, Re3), (Ra27 , Rb1, Re4), (Ra27, Rb1, Re5), (Ra27, Rb1, Re6), (Ra27, Rb1, Re7), (Ra27, Rb1, Re8), (Ra27, Rb1, Re9), (Ra27, Rb1 , Re10), (Ra27, Rb1,) Re11), (Ra27, Rb1, Re12), (Ra27, Rb1, Re13), (Ra27, Rb2, Re1), (Ra27, Rb2, Re2), (Ra27, Rb2, Re3 ), (Ra27, Rb2, Re4), (Ra27, Rb2, Re5), (Ra27, Rb2, Re6), (Ra27, Rb2, Re7), (Ra27, Rb2, Re8), (Ra27, Rb2, Re9), (Ra27, Rb2, Re10), (Ra27, Rb2, Re11), (Ra27, Rb2, Re12), (Ra27, Rb2, Re13).

(Test example)
The in vitro antibacterial activity of the compound (I) of the present invention was confirmed.
(Test method)
Minimum inhibitory concentration: Measurements of (MIC μg / mL) is according to the CLSI (clinical and Laboratory Standards Institute) method, the amount of test bacteria 5 × ¹⁰ 5 cfu / mL, the test medium using cation adjusted Mueller Hinton broth This was carried out by a micro liquid dilution method. The strains used are shown in Table 1.

The following existing drugs were used as comparative compounds.

(result)
The results of Example compounds are shown in Tables 2 and 3, and the results of comparative compounds are shown in Table 4. The unit of the antibacterial activity (MIC) in the table is μg / ml.

Compounds of the present invention I-2, I-3, I-12, I-1 and I-27 obtained by converting carboxy at the 4-position of cephem to tetrazole relative to Comparative compounds 1 to 5 are β-lactamase production gram It showed strong antibacterial action against negative bacteria, especially ESBL-producing bacteria.
The compound of the present invention also showed a strong antibacterial action against gram-positive bacteria such as penicillin resistant pneumococci (PRSP).

Hereinafter, biological test examples of the compounds of the present invention will be described.

Test Example 1: Examination of BA test oral absorbability Experimental materials and methods (1) Animals used: Mice or SD rats were used.
(2) Breeding conditions: Mice or SD rats were allowed to freely take solid feed and sterilized tap water.
(3) Setting of dose and grouping: Oral administration and intravenous administration were administered at a predetermined dose. Groups were set up as follows. (Dose may vary for each compound)
Oral administration 1-30 mg / kg (n = 2-3)
Intravenous administration 0.5-10 mg / kg (n = 2-3)
(4) Preparation of administration solution: Oral administration was administered as a solution or suspension. Intravenous administration was solubilized.
(5) Administration method: Oral administration was forcibly administered into the stomach with an oral sonde. Intravenous administration was carried out from the tail vein using a syringe with an injection needle.
(6) Evaluation items: Blood was collected over time, and the concentration of the compound of the present invention in plasma was measured using LC / MS / MS.
(7) Statistical analysis: The plasma concentration-time curve area (AUC) is calculated using the non-linear least squares program WinNonlin (Registered Trademark) for plasma compound concentration transition, and the oral administration group and intravenous administration The bioavailability (BA) of the compound of the present invention was calculated from the AUC of the group.

Test Example 2: About 5 mg of visual solubility test compound was weighed into three microscopic test tubes, and each medium (water for injection, saline injection, 0.5% glucose solution) was added to a compound concentration of 20%. After stirring by vortex, the presence or absence of dissolution was confirmed visually. If so, the solubility in the medium was> 20%. Each medium (water for injection, saline feed, glucose solution) was further added to these test solutions to prepare a test solution with a compound concentration of 10%. After vortexing, the presence or absence of dissolution was confirmed visually. If dissolved, the solubility in the medium was set to 20% to 10%. Similarly, the test was conducted up to 5% concentration, 2.5% concentration, and 1% concentration, and when it did not dissolve at 1% concentration, the solubility in the medium was set to <1%. The pH in a 1% test solution was measured and recorded.

Test Example 3: Solubility test The solubility of the compound of the present invention is determined under the condition of addition of 1% DMSO. Prepare a 10 mmol / L compound solution in DMSO, add 6 μL of the compound solution of the present invention to pH 6.8 artificial intestinal fluid (0.2 mol / L potassium dihydrogen phosphate test solution 250 mL, add 0.2 mol / L NaOH test solution 118 mL, water) Add to 594 μL. After allowing to stand at 25 ° C. for 16 hours, the mixed solution is subjected to suction filtration. The filtrate is diluted 2-fold with methanol / water = 1/1 (V / V), and the concentration in the filtrate is measured by HPLC or LC / MS / MS by the absolute calibration method.

Test Example 4: Powder Solubility Test An appropriate amount of the compound of the present invention is placed in an appropriate container, and JP-1 solution (2.0 g of sodium chloride, 7.0 mL of hydrochloric acid is added to 1000 mL) and JP-2 solution are added to each container. (Add 500 mL of water to 500 mL of phosphate buffer at pH 6.8), 20 mmol / L sodium taurocholate (TCA) / JP-2 solution (JP-2 solution is added to 1.08 g of TCA to make 100 mL) 200 μL each Added. When the entire amount is dissolved after the addition of the test solution, the compound of the present invention is appropriately added. After sealing at 37 ° C. for 1 hour, the mixture is filtered, and 100 μL of methanol is added to 100 μL of each filtrate to perform 2-fold dilution. Change the dilution factor as necessary. Check for bubbles and deposits, seal and shake. The compound of the present invention is quantified using HPLC by the absolute calibration curve method.

Test Example 5: CYP Inhibition Test O-deethylation of 7-ethoxyresorufin as a typical substrate metabolic reaction of human major CYP5 molecular species (CYP1A2, 2C9, 2C19, 2D6, 3A4) using commercially available pooled human liver microsomes (CYP1A2), methyl-hydroxylation of tolbutamide (CYP2C9), 4′-hydroxylation of mephenytoin (CYP2C19), O-demethylation of dextromethorphan (CYP2D6), and hydroxylation of terfenadine (CYP3A4), respectively. The degree to which the amount of metabolite produced is inhibited by the compound of the present invention is evaluated.

The reaction conditions are as follows.
Substrate, 0.5 μmol / L ethoxyresorufin (CYP1A2), 100 μmol / L tolbutamide (CYP2C9), 50 μmol / L S-mephenytoin (CYP2C19), 5 μmol / L dextromethorphan (CYP2D6), 1 μmol / L terfenadine (CYP3A4) Reaction time, 15 minutes; reaction temperature, 37 ° C .; enzyme, pooled human liver microsome 0.2 mg protein / mL; concentration of the compound of the present invention 1, 5, 10, 20 μmol / L (4 points)

As a reaction solution in a 96-well plate, each of 5 types of substrate, human liver microsome, and the compound of the present invention are added in the above composition in a 50 mmol / L Hepes buffer solution, and NADPH, a coenzyme, is added as an indicator for metabolic reaction. To start. After reacting at 37 ° C. for 15 minutes, the reaction is stopped by adding a methanol / acetonitrile = 1/1 (V / V) solution. After centrifuging at 3000 rpm for 15 minutes, resorufin (CYP1A2 metabolite) in the centrifugation supernatant was quantified with a fluorescent multi-label counter, tolbutamide hydroxide (CYP2C9 metabolite), mephenytoin 4 ′ hydroxide (CYP2C19 metabolite) , Dextrorphan (CYP2D6 metabolite) and terfenadine alcohol (CYP3A4 metabolite) are quantified by LC / MS / MS.

The control (100%) was obtained by adding only DMSO, which is a solvent in which the drug was dissolved, to the reaction system, the residual activity (%) was calculated, and the IC ₅₀ was calculated by inverse estimation using a logistic model using the concentration and the inhibition rate. calculate.

Test Example 6: Metabolic stability test A commercially available pooled human liver microsome and the compound of the present invention are reacted for a certain period of time, and the residual ratio is calculated by comparing the reaction sample with the unreacted sample to evaluate the degree of metabolism of the compound of the present invention in the liver. To do.

In 0.2 mL buffer (50 mmol / L Tris-HCl pH 7.4, 150 mmol / L potassium chloride, 10 mmol / L magnesium chloride) containing 0.5 mg protein / mL human liver microsomes in the presence of 1 mmol / L NADPH React at 37 ° C. for 0 or 30 minutes (oxidative reaction). After the reaction, 50 μL of the reaction solution was added to 100 μL of a methanol / acetonitrile = 1/1 (v / v) solution, mixed, and centrifuged at 3000 rpm for 15 minutes. The compound of the present invention in the centrifugal supernatant is quantified by LC / MS / MS, and the residual amount of the compound of the present invention after the reaction is calculated with the compound amount at 0 minute reaction as 100%. The hydrolysis reaction is carried out in the absence of NADPH, the glucuronic acid conjugation reaction is carried out in the presence of 5 mmol / L UDP-glucuronic acid instead of NADPH, and the same operation is carried out thereafter.

Test Example 7: CYP3A4 Fluorescence MBI Test The CYP3A4 fluorescence MBI test is a test for examining the enhancement of CYP3A4 inhibition of the compound of the present invention by metabolic reaction. 7-Benzyloxytrifluoromethylcoumarin (7-BFC) is debenzylated by CYP3A4 enzyme (E. coli-expressed enzyme) to produce a fluorescent metabolite 7-hydroxytrifluoromethylcoumarin (7-HFC). CYP3A4 inhibition is evaluated using 7-HFC production reaction as an index.

The reaction conditions are as follows.
Substrate, 5.6 μmol / L 7-BFC; pre-reaction time, 0 or 30 minutes; reaction time, 15 minutes; reaction temperature, 25 ° C. (room temperature); CYP3A4 content (E. coli expression enzyme), 62.5 pmol / mL, 6.25 pmol / mL at the time of reaction (10-fold dilution); concentration of the compound of the present invention, 0.625, 1.25, 2.5, 5, 10, 20 μmol / L (6 points)

The enzyme and the compound solution of the present invention are added to the 96-well plate as a pre-reaction solution in K-Pi buffer (pH 7.4) in the above-mentioned pre-reaction composition, and the substrate and K-Pi buffer are added to another 96-well plate. Transfer part of it to be diluted 1/10. The reaction using NADPH as a coenzyme is started (no pre-reaction), and after reaction for a predetermined time, acetonitrile / 0.5 mol / L Tris (trishydroxyaminomethane) = 4/1 (V / V ) To stop the reaction. In addition, NADPH is also added to the remaining pre-reaction solution to start the pre-reaction (pre-reaction is present), and after pre-reaction for a predetermined time, one plate is diluted to 1/10 with the substrate and K-Pi buffer. Start the reaction with the part as the indicator. After the reaction for a predetermined time, the reaction is stopped by adding acetonitrile / 0.5 mol / L Tris (trishydroxyaminomethane) = 4/1 (V / V). The fluorescence value of 7-HFC, which is a metabolite, is measured using a fluorescent plate reader on the plate on which each index reaction has been performed. (Ex = 420nm, Em = 535nm)

A control (100%) was obtained by adding only DMSO, which is a solvent in which the compound of the present invention was dissolved, to the reaction system, and the residual activity (%) when each concentration of the compound of the present invention was added was calculated. Is used to calculate IC ₅₀ by inverse estimation using a logistic model. The case where the difference in IC ₅₀ value is 5 μmol / L or more is (+), and the case where it is 3 μmol / L or less is (−).

Test Example 8: Fluctuation Ames Test
This is a test for evaluating the mutagenicity of the compound of the present invention.
20 μL of Salmonella typhimurium TA98 strain, TA100 strain, which has been cryopreserved, is inoculated into 10 mL liquid nutrient medium (2.5% Oxoid nutritive broth No. 2) and cultured at 37 ° C. for 10 hours before shaking. For TA98 strain, 9 mL of the bacterial solution is centrifuged (2000 × g, 10 minutes) to remove the culture solution. 9 mL of Micro F buffer (K ₂ HPO ₄ : 3.5 g / L, KH ₂ PO ₄ : 1 g / L, (NH ₄ ) ₂ SO ₄ : 1 g / L, trisodium citrate dihydrate: 0. MicroF containing 110 mL Exposure medium (Biotin: 8 μg / mL, Histidine: 0.2 μg / mL, Glucose: 8 mg / mL) suspended in 25 g / L, MgSO ₄ · 7H ₂ 0: 0.1 g / L) Buffer). The TA100 strain is added to 120 mL of Exposure medium with respect to the 3.16 mL bacterial solution to prepare a test bacterial solution. Compound DMSO solution of the present invention (maximum dose of 50 mg / mL to several-fold dilution at 2-3 times common ratio), DMSO as a negative control, and non-metabolic activation conditions as a positive control, 50 μg / mL 4-TA Nitroquinoline-1-oxide DMSO solution, 0.25 μg / mL 2- (2-furyl) -3- (5-nitro-2-furyl) acrylamide DMSO solution for TA100 strain, TA98 under metabolic activation conditions 40 μg / mL 2-aminoanthracene DMSO solution for the strain and 20 μg / mL 2-aminoanthracene DMSO solution for the TA100 strain, respectively, and 588 μL of the test bacterial solution (under the metabolic activation conditions, 498 μL of the test bacterial solution and S9 mix 90 μL of the mixture) and incubate with shaking at 37 ° C. for 90 minutes. 460 μL of the bacterial solution exposed to the compound of the present invention was added 2300 μL of Indicator medium (MicroF buffer containing biotin: 8 μg / mL, histidine: 0.2 μg / mL, glucose: 8 mg / mL, bromocresol purple: 37.5 μg / mL). 50 μL each, and dispensed into 48 wells / dose of the microplate, and statically cultured at 37 ° C. for 3 days. Since wells containing bacteria that have acquired growth ability by mutation of the amino acid (histidine) synthase gene change from purple to yellow due to pH change, the number of bacteria growth wells that changed to yellow in 48 wells per dose was counted. Evaluation is made in comparison with the negative control group. A negative mutagenicity is indicated as (−), and a positive mutagenicity is indicated as (+).

Test Example 9: hERG Test For the purpose of evaluating the risk of prolonging the electrocardiogram QT interval of the compound of the present invention, using HEK293 cells expressing human ether-a-go-related gene (hERG) channel, it is important for ventricular repolarization process Consider the action of the compounds of the present invention on the delayed rectifier K ⁺ current (I _Kr ) that plays a role.
Using a fully automatic patch clamp system (PatchXpress 7000A, Axon Instruments Inc.), the cells were held at a membrane potential of −80 mV by the whole cell patch clamp method, followed by a +40 mV depolarization stimulus for 2 seconds and a further −50 mV repolarization. Record the I _Kr elicited when the stimulus is applied for 2 seconds. After the generated current is stabilized, an extracellular fluid (NaCl: 135 mmol / L, KCl: 5.4 mmol / L, NaH ₂ PO ₄ : 0.3 mmol / L, in which the compound of the present invention is dissolved at a target concentration, CaCl ₂ · 2H ₂ O: 1.8 mmol / L, MgCl ₂ · 6H ₂ O: 1 mmol / L, glucose: 10 mmol / L, HEPES (4- (2-hydroxyethyl) -1-piperazine ethersulfonic acid, 4- (2- Hydroxyethyl) -1-piperazineethanesulfonic acid): 10 mmol / L, pH = 7.4) is applied to the cells for 10 minutes at room temperature. From the obtained I _Kr , the absolute value of the maximum tail current is measured based on the current value at the holding membrane potential using analysis software (DataXpress ver. 1, Molecular Devices Corporation). Furthermore, the inhibition rate with respect to the maximum tail current before application of the compound of the present invention is calculated, and compared with the vehicle application group (0.1% dimethyl sulfoxide solution), the effect of the compound of the present invention on I _Kr is evaluated.

(Formulation example 1)
An injection is prepared by powder filling the compound of the present invention.

The compound of the present invention has a broad antibacterial spectrum against gram-positive and gram-negative bacteria, and is particularly effective against penicillin-resistant pneumococci and β-lactamase-producing gram-negative bacteria. In addition, since it has good pharmacokinetics and high water solubility, it is particularly effective as an injection.

Claims

Formula (I):

(Where
W is —CH 2 —, —S— or —O—,
a) when W is —CH 2 —, U is —CH 2 —, —S—, —S (═O) — or —O—, or b) W is —S— or —O—. When U is —CH 2 —;
L is a single bond, -CH 2 -, - CH = CH -, - S -, - CH 2 -S -, - CH = CH-S -, - CH = CH-CH 2 -S-, and the following formula :

Wherein Y 1 and Y 2 are each independently —CR 4 R 5 —, —C (═O) —, —NR 4 —, —O— or —S (═O) 2 — 4 and R 5 are each independently a hydrogen atom, substituted or unsubstituted lower alkyl or halogen, and n is an integer of 1 to 3.
A group selected from
G is a single bond or a substituted or unsubstituted heterocyclic group,
R 1 is a substituted or unsubstituted carbocyclic group or a substituted or unsubstituted heterocyclic group;
R 2A and R 2B together form oxo, substituted or unsubstituted methylidene, or substituted or unsubstituted hydroxyimino;
R 3 is a hydrogen atom, —OCH 3 or —NH—CH (═O),
R 11 is a carboxy cyclic bioisostere;
R 20 represents the following formulas (Ia) and (Ib):

Wherein R 10a is a hydrogen atom, halogen, hydroxy, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted Lower alkoxy, substituted or unsubstituted acyl, substituted or unsubstituted carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted acyloxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aromatic carbocyclic A group, a substituted or unsubstituted non-aromatic heterocyclic group or a substituted or unsubstituted aromatic heterocyclic group,
E is the formula:

(In the formula, the bond from the cationic nitrogen atom indicates the bond with R 10b , the other bond indicates the bond with G, and the broken line indicates a single bond between the cationic nitrogen atom and the adjacent atom. Or a lower alkylene between a cationic nitrogen atom and a ring member atom other than an adjacent atom.)
A divalent heterocyclic group containing a substituted or unsubstituted saturated or unsaturated monocyclic or condensed quaternary ammonium ion, wherein R 10b is a substituted or unsubstituted amino, substituted Or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, or substituted or unsubstituted lower alkoxy)
Is a group selected from
However, the following:
1) Compounds (A-1) and (A-3):

and,
2) L is -S -, - CH 2 -S - , - CH = CH-S- or -CH = CH-CH 2 -S-, G is a single bond, R 20 is formula (Ib), and, E Is monocyclic or fused-ring pyridinium substituted with at least two adjacent hydroxys,
except for. )
Or a pharmaceutically acceptable salt thereof.
R 1 is the formula:

(Wherein X is N, C (—H) or C (—R 12 ), and R 12 is halogen)
The compound of Claim 1 which is group shown by these, or its pharmaceutically acceptable salt.
The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein X is C (-H) or C (-Cl).
R 2A and R 2B taken together are oxo, substituted methylidene as shown below:

(Wherein R 14 is substituted or unsubstituted lower alkyl, and the wavy bond means cis, trans, or a mixture thereof)
Or a substituted or unsubstituted hydroxyimino as shown below:

(Wherein R 9 is a hydrogen atom or a substituted or unsubstituted lower alkyl)
The compound according to any one of claims 1 to 3, and a pharmaceutically acceptable salt thereof.
R 2A and R 2B taken together form the substituted hydroxyimino shown below

Wherein R 7 and R 8 are each independently a hydrogen atom, halogen, hydroxy, carboxy, substituted or unsubstituted lower alkyl, substituted or unsubstituted carbocyclic group, or substituted or unsubstituted heterocyclic Or R 7 and R 8 together with adjacent atoms may form a substituted or unsubstituted carbocyclic ring or a substituted or unsubstituted heterocyclic ring,
Q is a single bond, a substituted or unsubstituted carbocycle, or a substituted or unsubstituted heterocycle,
m represents an integer of 0 to 3)
Or

The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof.
R 2A and R 2B together are substituted methylidene as shown below:

(Wherein the wavy bond means cis, trans, or a mixture thereof)
The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof.
The compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, wherein R 3 is a hydrogen atom or -OCH 3 .
The R 11 carboxy cyclic bioisostere has the formula:

(In the formula, R 13 is a group having an electron-withdrawing property)
The compound according to any one of claims 1 to 7, or a pharmaceutically acceptable salt thereof, selected from:
Carboxy cyclic bioisosteres have the formula:

The compound according to any one of claims 1 to 7, or a pharmaceutically acceptable salt thereof, which is a group represented by:
R 20 represents formula (Ia):

The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof.
R 20 represents formula (Ib):

The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof.
The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, wherein E is a divalent group containing a substituted or unsubstituted monocyclic or condensed ring pyridinium.
E is the formula:

(In the formula, one or more substituents selected from halogen, lower alkyl, and lower alkoxy may be the same or different on the ring.)
The compound according to any one of claims 1 to 9 and 11, or a pharmaceutically acceptable salt thereof, which is a group selected from:
E is the formula:

(In the formula, one or more substituents selected from halogen, lower alkyl, and lower alkoxy may be the same or different on the ring.)
The compound according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, which is a group represented by:
R 10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted ethyl, substituted or unsubstituted methoxy, substituted or unsubstituted ethoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy Substituted or unsubstituted aminomethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, substituted or unsubstituted carbamoylethyl, substituted or unsubstituted piperazylcarbonylmethyl, substituted or unsubstituted morpholine Nylcarbonylmethyl, substituted or unsubstituted piperazylcarbonylethyl, substituted or unsubstituted morpholinylcarbonylethyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted dihydropyrimimi Dinyl, substituted or unsubstituted dihydropyridanidyl, substituted or unsubstituted quinolyl, substituted or unsubstituted phenyl, substituted or unsubstituted pyridyl, substituted or unsubstituted pyrimidyl, substituted or unsubstituted pyridazyl, substituted or unsubstituted Substituted pyrazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted dihydrooxazolyl, substituted or unsubstituted oxadiazolyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted dihydroimidazolyl, Substituted or unsubstituted isothiazolyl, substituted or unsubstituted isoxadiazolyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted tetra A dihydrothiazolyl Lil, or a substituted or unsubstituted compound or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 10.
R 10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy substituted or unsubstituted aminoethyl, substituted or unsubstituted pyrrolyl Substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, substituted Alternatively, the compound according to any one of claims 1 to 10, or a pharmaceutically acceptable salt thereof, which is unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl.
R 10b is substituted or unsubstituted methyl, substituted or unsubstituted ethyl, substituted or unsubstituted aminomethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, substituted or unsubstituted carbamoylethyl, substituted Or an unsubstituted piperazylcarbonylmethyl, a substituted or unsubstituted morpholinylcarbonylmethyl, a substituted or unsubstituted piperazinylcarbonylethyl, or a substituted or unsubstituted morpholinylcarbonylethyl, 15. The compound according to any one of 11 to 14, or a pharmaceutically acceptable salt thereof.
Any one of claims 1-9 and 11-14, wherein R 10b is substituted or unsubstituted ethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, or substituted or unsubstituted piperazinylcarbonylmethyl. Or a pharmaceutically acceptable salt thereof.
The compound according to any one of claims 1 to 18, or a pharmaceutically acceptable salt thereof, wherein W is -CH 2- .
The compound according to any one of claims 1 to 19, or a pharmaceutically acceptable salt thereof, wherein U is -S- or -O-.
L is a single bond, —CH 2 —, —CH═CH—, —S—, —CH 2 —S— or the following formula:

The compound according to any one of claims 1 to 20, or a pharmaceutically acceptable salt thereof, which is a group represented by:
G is a single bond or formula:

The compound according to any one of claims 1 to 21, or a pharmaceutically acceptable salt thereof, which is a group represented by:
W is —CH 2 —;
U is -S- or -O-;
L is a single bond, —CH 2 —, —CH═CH—, —S—, —CH 2 —S— or the following formula:

A group represented by
G is a single bond or formula:

A group represented by
R 1 is the formula:

(Wherein X is N, C (—H) or C (—R 12 ), and R 12 is halogen)
A group represented by
R 2A and R 2B taken together are oxo, substituted methylidene as shown below:

(Wherein R 14 is substituted or unsubstituted lower alkyl, and the wavy bond means cis, trans, or a mixture thereof)
Or a substituted or unsubstituted hydroxyimino as shown below:

(Wherein R 9 is a hydrogen atom or a substituted or unsubstituted lower alkyl)
And
R 3 is a hydrogen atom or -OCH 3,
R 11 represents the formula:

A group represented by
R 10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aminoethyl, substituted or unsubstituted Pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, Substituted or unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl,
E is a divalent group containing substituted or unsubstituted pyridinium;
The compound according to claim 1, wherein R 10b is substituted or unsubstituted ethyl, substituted or unsubstituted aminoethyl, substituted or unsubstituted carbamoylmethyl, or substituted or unsubstituted piperazinylcarbonylmethyl, or a pharmaceutically acceptable salt thereof. Acceptable salt.
W is —CH 2 —;
U is -S- or -O-;
L is a single bond, —CH 2 —, —CH═CH—, —S—, —CH 2 —S— or the following formula:

A group represented by
G is a single bond or formula:

A group represented by
R 1 is the formula:

(Wherein X is N, C (—H) or C (—R 12 ), and R 12 is halogen)
A group represented by
R 2A and R 2B taken together are oxo, substituted methylidene as shown below:

(Wherein R 14 is substituted or unsubstituted lower alkyl, and the wavy bond means cis, trans, or a mixture thereof)
Or a substituted or unsubstituted hydroxyimino as shown below:

(Wherein R 9 is a hydrogen atom or a substituted or unsubstituted lower alkyl)
And
R 3 is a hydrogen atom or -OCH 3,
R 11 represents the formula:

A group represented by
R 20 is R 10a ;
R 10a is a hydrogen atom, amino, substituted or unsubstituted methyl, substituted or unsubstituted methoxy, substituted or unsubstituted acetoxy, substituted or unsubstituted carbamoyloxy, substituted or unsubstituted aminoethyl, substituted or unsubstituted Pyrrolyl, substituted or unsubstituted dihydrotriazinyl, substituted or unsubstituted tetrahydrotriazinyl, substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, The compound according to claim 1, which is substituted or unsubstituted tetrazolyl or substituted or unsubstituted dihydrothiazolyl, or a pharmaceutically acceptable salt thereof.
formula:

The compound of Claim 1 selected from these, or its pharmaceutically acceptable salt.
A pharmaceutical composition comprising the compound according to any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof.
27. The pharmaceutical composition according to claim 26, which has an antibacterial action.
The compound according to any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof for the treatment and / or prevention of an infectious disease.
A method for treating and / or preventing an infectious disease, comprising administering the compound according to any one of claims 1 to 25 or a pharmaceutically acceptable salt thereof.