WO2014152985A8 - Biomarkers of preterm necrotizing enterocolitis - Google Patents

Biomarkers of preterm necrotizing enterocolitis Download PDF

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Publication number
WO2014152985A8
WO2014152985A8 PCT/US2014/028544 US2014028544W WO2014152985A8 WO 2014152985 A8 WO2014152985 A8 WO 2014152985A8 US 2014028544 W US2014028544 W US 2014028544W WO 2014152985 A8 WO2014152985 A8 WO 2014152985A8
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
preterm
necrotizing enterocolitis
enterocolitis
necrotizing
Prior art date
Application number
PCT/US2014/028544
Other languages
French (fr)
Other versions
WO2014152985A1 (en
Inventor
Ardythe L. Morrow
Kurt SCHIBLER
Michael A. Kennedy
David S. Newburg
Original Assignee
Children's Hospital Medical Center
Miami University
Boston College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children's Hospital Medical Center, Miami University, Boston College filed Critical Children's Hospital Medical Center
Publication of WO2014152985A1 publication Critical patent/WO2014152985A1/en
Publication of WO2014152985A8 publication Critical patent/WO2014152985A8/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/10—Enterobacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for identifying a preterm infant having or at risk for necrotizing enterocolitis (NEC) based on metabolomics biomarkers in urine samples and/or microbial biomarkers in stool samples.
PCT/US2014/028544 2013-03-14 2014-03-14 Biomarkers of preterm necrotizing enterocolitis WO2014152985A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783018P 2013-03-14 2013-03-14
US61/783,018 2013-03-14

Publications (2)

Publication Number Publication Date
WO2014152985A1 WO2014152985A1 (en) 2014-09-25
WO2014152985A8 true WO2014152985A8 (en) 2014-12-31

Family

ID=51581378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/028544 WO2014152985A1 (en) 2013-03-14 2014-03-14 Biomarkers of preterm necrotizing enterocolitis

Country Status (1)

Country Link
WO (1) WO2014152985A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017141169A1 (en) * 2016-02-16 2017-08-24 Tata Consultancy Services Limited Method and system for early risk assessment of preterm delivery outcome
WO2020210754A1 (en) 2019-04-10 2020-10-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Computational filtering of methylated sequence data for predictive modeling
WO2022056032A1 (en) * 2020-09-08 2022-03-17 The Regents Of The University Of California A newborn metabolic vulnerability model for identifying preterm infants at risk of adverse outcomes, and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000022945A2 (en) * 1998-10-20 2000-04-27 Societe Des Produits Nestle S.A. Protein for treatment or prevention of a gastrointestinal tract disorder
EP2179282B1 (en) * 2007-06-29 2016-06-01 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
JP5766947B2 (en) * 2007-09-07 2015-08-19 チルドレンズ ホスピタル メディカル センター Use of secreted Lewis and sialylated antigen levels in clinical samples as predictors of disease risk
WO2012142605A1 (en) * 2011-04-15 2012-10-18 Samaritan Health Services Rapid recolonization deployment agent

Also Published As

Publication number Publication date
WO2014152985A1 (en) 2014-09-25

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