WO2014146464A1 - 一种经皮给药装置 - Google Patents

一种经皮给药装置 Download PDF

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Publication number
WO2014146464A1
WO2014146464A1 PCT/CN2013/089618 CN2013089618W WO2014146464A1 WO 2014146464 A1 WO2014146464 A1 WO 2014146464A1 CN 2013089618 W CN2013089618 W CN 2013089618W WO 2014146464 A1 WO2014146464 A1 WO 2014146464A1
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WO
WIPO (PCT)
Prior art keywords
annular
cavity
top surface
wall
negative pressure
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Application number
PCT/CN2013/089618
Other languages
English (en)
French (fr)
Inventor
陈刚
王梅林
Original Assignee
北京神州汉方医药科技有限公司
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Publication date
Application filed by 北京神州汉方医药科技有限公司 filed Critical 北京神州汉方医药科技有限公司
Priority to JP2015558334A priority Critical patent/JP6205434B2/ja
Priority to US14/655,641 priority patent/US10052466B2/en
Priority to EP13879016.7A priority patent/EP2977076B1/en
Publication of WO2014146464A1 publication Critical patent/WO2014146464A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/92—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with liquid supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/94—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with gas supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1586—Holding accessories for holding infusion needles on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Definitions

  • the present invention relates to the field of medical devices, and more particularly to a transdermal drug delivery device.
  • the top surface of the outer ring cavity and the top surface of the central cavity are the same plane or curved surface formed by close connection. Since the application tray has a certain thickness, the top surface has a certain distance from the skin, and when the application tray is applied to a relatively flat part of the body, it can be applied very firmly, but when the application tray is applied to the uneven portion, For example, when the curvature of the neck, leg, arm, etc. is relatively large, the top surface of the central cavity of the applicator disk will have a large pinning force on the top surface of the connected outer ring cavity, which weakens the adsorption of the outer ring cavity by the negative pressure. Force, the dressing plate is easy to fall off, affecting the normal progress of the treatment process.
  • the temperature of the air in the central cavity is gradually increased under the skin temperature or/and the external heat source, and the volatile components in the drug are gradually released, so that the pressure in the central cavity is gradually increased. Promotes percutaneous penetration of the drug.
  • the increased pressure also causes the top surface of the central cavity to be lifted outwardly away from the surface of the skin. When the pressure is high, the top surface is convex outward, which causes a great pulling force on the top surface of the connected outer ring cavity. It weakens the adsorption force generated by the negative pressure in the outer ring cavity, which makes the applicator plate easy to fall off and affects the normal progress of the treatment process.
  • the vacuum tube is located on the top surface of the outer ring cavity.
  • the pulling force of the vacuum tube is directly transmitted to the annular outer wall through the top surface of the outer ring cavity, thereby weakening the adsorption force generated by the negative pressure in the outer ring cavity.
  • the application tray is easily detached, which affects the normal progress of the treatment process.
  • the invention provides a transdermal drug delivery device, which solves the problem that the adsorption force generated by the negative pressure of the outer ring cavity is weakened in the prior art, and the applicator disk is easily detached.
  • a transdermal delivery device comprising:
  • first top surface and an annular outer wall and an annular inner wall disposed on both sides of the first top surface and fixed to a side of the first top surface, the first top surface, the annular outer wall and the annular inner wall constitute a first annular cavity;
  • a first connecting pipe one end is connected to the first ring cavity, and the other end is connected to the negative pressure source;
  • the central annular cavity includes a first annular wall and a second top surface, and the first annular wall is connected to one end of the annular inner wall through the first annular bottom surface;
  • the annular inner wall, the first annular bottom surface and the first annular wall constitute a first annular groove opening in the direction of the first top surface.
  • the method further includes: a second annular wall, a third annular wall and a second annular bottom surface; the second annular wall, the third annular wall and the second annular bottom surface constitute a second annular groove opening in the second top surface direction.
  • the method further includes: a fourth annular wall and a second connecting tube, wherein the fourth annular wall and the second top surface constitute a second annular cavity; the first annular wall, the fourth annular wall and the second top surface form a central partial ring cavity One end of the second connecting pipe is in communication with the second ring cavity, and the other end is connected to the negative pressure source.
  • the method further includes: a connecting post for supporting the first connecting pipe, disposed on the second top surface; one end of the first connecting pipe communicates with the first ring cavity through the connecting post, and the other end is in communication with the negative pressure source.
  • the first connecting tube further includes: a negative pressure source connecting section and a first annular cavity connecting section; the negative pressure source connecting section is in communication with the first annular cavity connecting section, and the first annular cavity connecting section has one end and the first annular cavity The connection between the other end and the connection port of the negative pressure source is in communication with the second ring cavity.
  • the length of the first annular cavity connecting section is greater than the linear distance of the horizontal state of the first annular cavity and the second annular cavity.
  • the method further includes: a third annular wall and a fourth annular wall; the third annular wall and the second top surface constitute a third annular cavity; the fourth annular wall and the second top surface constitute a fourth annular cavity; and the second ring The cavity, the third ring cavity and the fourth ring cavity are equally divided on the second top surface.
  • the first connecting pipe comprises: a second ring cavity connecting section, one end is in communication with the third ring cavity, and the other end is in communication with the negative pressure source section; the third ring cavity connecting section is connected to the fourth ring cavity at one end, and the other end is connected Connected to the negative pressure source section.
  • the method further comprises: an annular pad for preventing the skin from being excessively stretched under the action of the negative pressure, and the skin is damaged, and is disposed in the first annular cavity.
  • the annular pad is a breathable annular pad.
  • the first annular groove formed by the annular inner wall, the first annular bottom surface and the first annular wall is attached to the uneven portion (such as the back neck, the leg, and the arm) having different curvatures on the body surface, due to the first
  • the annular groove separates the first top surface and the second top surface, and the first annular groove can change the curvature of the upper end by a suitable curvature, thereby preventing the second top from being pinned against the first annular cavity, so Clothing is not easy to fall off in uneven parts;
  • the second annular cavity can be attached to the skin, thereby reducing the deformation of the top surface outward due to the increase of gas pressure. Degree, so it is not easy to fall off;
  • the force acts first on the second top surface, and the second top surface can be elastically deformed accordingly.
  • the force is dissipated to prevent it from being directly transmitted to the first annular cavity, thereby preventing it from weakening the adsorption force of the first annular cavity, and thus is not easy to fall off.
  • the negative pressure source connecting section and the first annular cavity connecting section are connected, since the force applied to the first connecting pipe is applied to the second top surface, the adsorption force of the first annular cavity can be prevented from being weakened, so that it is difficult to be Fall off.
  • Figure 1 is a schematic view showing the structure of an embodiment of a transdermal drug delivery device of the present invention
  • FIG. 2 is a schematic structural view of another embodiment of a transdermal drug delivery device according to the present invention.
  • Figure 3 is a schematic view showing the structure of a transdermal drug delivery device according to still another embodiment of the present invention.
  • Figure 4 is a schematic view showing the structure of a transdermal drug delivery device according to still another embodiment of the present invention.
  • Figure 5 is a schematic view showing the structure of a transdermal drug delivery device according to still another embodiment of the present invention.
  • Figure 6 is a schematic view showing the structure of a transdermal drug delivery device according to still another embodiment of the present invention.
  • Figure 7 is a schematic view showing the structure of an embodiment of a central annulus in a transdermal drug delivery device of the present invention.
  • a transdermal delivery device comprises:
  • the first connecting pipe 5 has one end connected to the first ring cavity 4 and the other end being connected to the negative pressure source;
  • the central annular cavity (6) includes a first annular wall 7 and a second top surface 8, and the first annular wall 7 is connected to one end of the annular inner wall 3 through the first annular bottom surface 9;
  • the annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7 constitute a first annular groove 10 opening in the direction of the first top surface 1.
  • the first annular groove 10 formed by the annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7 is attached to the uneven portion of the body surface having different curvatures (such as the back neck, the leg, the arm),
  • the annular groove 10 separates the first top surface 1 and the second top surface 8, and the first annular groove 10 can be changed by a suitable curvature of the upper end thereof, thereby preventing the second top surface 8 from facing the first annular chamber 4.
  • the pinning, so that the patch is not easy to fall off in the uneven part.
  • the first annular cavity 4 is formed by the first top surface 1, the annular outer wall 2 and the annular inner wall 3, wherein one end of the first connecting tube 5 is in communication with the first annular chamber 4, and the other end is negative.
  • the pressure source communicates with a central annular cavity 6 composed of a first annular wall 7 and a second top surface 8, and the first annular wall 7 is connected to one end of the first annular bottom surface 9, and one end of the first annular bottom surface 9 is connected to the annular inner wall 3.
  • annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7 constitute a first annular groove 10; in the use phase, the first annular cavity 4 and the central annular cavity 6 are applied to the skin 20 and the drug is placed In the central annular chamber 6, the negative pressure source generates an adsorption force to lift the skin 20 through the first connecting tube 5, so that the first annular chamber 4 is adsorbed on the skin 20, and at the same time, the central annular chamber 6 is completely sealed, so that it is located in the central ring.
  • the medicine in the cavity 6 is volatilized, it does not escape to the external environment, and when applied to the uneven portion, the open end of the first annular groove 10 is opened, and the spacing is increased to adapt to the change of the bending rate of the uneven portion. This avoids the pinching of the first top surface 1 by the second top surface 8 and avoids weakening A suction force of the annular chamber 4, so that not falling.
  • the second annular wall 21, the third annular wall 22 and the second annular bottom surface 23; the second annular wall 21 and the third annular wall 22 are further included.
  • a second annular bottom surface 23 constitutes a second annular groove 24 opening in the direction of the second top surface 8.
  • the second annular wall 21 is connected to one end of the second annular bottom surface 23, and the third annular wall 22 is connected to the other end of the second annular bottom surface 23, and is formed by the second annular wall 21, the second annular bottom surface 23 and the third annular wall 22.
  • the design further avoids weakening the adsorption force of the first annular chamber 4, making it difficult to fall off.
  • the fourth annular wall 11 and the second connecting tube 12 are further formed, and the fourth annular wall 11 and the second top surface 8 constitute a second annular cavity 13
  • the first annular wall 7, the fourth annular wall 11 and the second top surface 8 constitute a central partial ring chamber 14; one end of the second connecting tube 12 is in communication with the second annular chamber 13, and the other end of the negative pressure source is in communication.
  • a second annular cavity 13 composed of a fourth annular wall 11 and a second top surface 8, and the second annular cavity 13 communicates with the negative pressure source through the second connecting pipe 12, and passes through the second annular cavity 13 to divide the central annular cavity 6
  • the second connecting tube 12 can be separately connected to the negative pressure source.
  • the second connecting tube 12 and the first connecting tube 5 can also be used in the case where the first connecting tube 5 is used.
  • the skin 20 under the second annular cavity 13 is adsorbed by the second connecting tube 12 under the action of the negative pressure source, that is, the central portion of the second top surface 8 is anchored, so that the gas is expanded or pressure gradually When the case is increased, the protrusion is not expanded outward, and the adsorption force of the first ring cavity 4 is not weakened, so that it is not easy to fall off.
  • the method further includes: a connecting post 15 for supporting the first connecting tube 5, disposed on the second top surface 8;
  • the connecting post 15 is in communication with the first annular chamber 4 and the other end is in communication with a source of negative pressure.
  • the second top surface 8 is provided with a connecting post 15 fixed thereto.
  • One end of the first connecting tube 5 passes through the connecting post 15 and is fixed on the connecting post 15, and the first connecting tube 5 passes through the connecting post.
  • One end of 15 is in communication with the first annular chamber 4, and the length of the first connecting tube 5 passing through the end of the connecting post 15 is greater than the line between the center point and the center point of the first annular chamber 4 when the first top surface 1 is in a water equilibrium state.
  • the distance of the first top surface 1 is not pinched; at the same time, since the first connecting tube 5 is fixed to the second top surface 8 through the connecting post 15, when the first connecting tube 5 is pulled, its force Firstly, it acts on the second top surface 8, and the second top surface 8 can resolve the force by corresponding elastic deformation, avoiding its direct transmission to the first top surface 1, thereby preventing it from weakening the adsorption force of the first annular chamber 4. Therefore, it is not easy to fall off.
  • the first connecting pipe 5 further comprises: a negative pressure source connecting section 16 and a first annular cavity connecting section 17; the negative pressure source connecting section 16 is in communication with the first annular cavity connecting section 17, and the first annular cavity connecting section 17 One end is in communication with the first annular chamber 4, and the other end is connected to the second annular chamber 13 at a junction with the negative pressure source connecting portion 16.
  • the length of the first annular cavity connecting section 17 is greater than the linear distance of the first annular cavity 4 and the second annular cavity 13 in a horizontal state.
  • the first connecting pipe 5 includes a negative pressure source connecting section 16 and a first annular cavity connecting section 17, and the first annular cavity connecting section 17 is connected to the first annular cavity 4.
  • the junction of the first annular cavity connecting section 17 and the negative pressure source connecting section 16 is in communication with the second annular cavity 13, wherein the length of the first annular cavity connecting section 17 is greater than that of the first annular cavity 4 and the second annular cavity 13
  • the linear distance in the horizontal state when applied to a portion with a large curvature of the body, the first annular cavity connecting portion 17 can have a sufficient length to accommodate the increase of the distance between the two ends, and the first top surface 1 is prevented from being pinched.
  • the skin 20 under the second annular cavity 13 is adsorbed by the first connecting tube 5 under the action of the negative pressure source, that is, the central portion of the second top surface 8 is anchored, so that it expands in gas, pressure
  • the protrusion is not expanded outward, and the adsorption force of the first ring chamber 4 is not weakened, so that it is not easy to fall off.
  • the method further includes: a third annular wall 22 and a fourth annular wall 11; the third annular wall 22 and the second top surface 8 constitute a third annular cavity 18; the fourth annular wall 11 and the second top surface 8 form a fourth The annular chamber 19; and the second annular chamber 13, the third annular chamber 18 and the fourth annular chamber 19 are equally disposed on the second top surface 8.
  • the third annular cavity 18 is formed by the third annular wall 22 and the second top surface 8, and the fourth annular wall 11 and the second top surface 8 constitute a fourth annular cavity. 19, and the second annular cavity 13, the third annular cavity 18 and the fourth annular cavity 19 are equally divided on the second top surface 8, and it is a preferred technical solution to provide a ring cavity in the present invention, in order to avoid the second top
  • the surface 8 cannot be expanded outwardly, and 4, 5 or more ring cavities can be disposed. To save space, the present embodiment does not limit this.
  • the second top surface 8 is provided with a ring.
  • the passage connects the second annular chamber 13, the third annular chamber 18 and the fourth annular chamber 19, and anchors the second top surface 8 through three parts, so that the second top surface 8 can be more effectively restrained from being
  • the outer expansion protrusions, thereby avoiding weakening the adsorption force of the first annular chamber 4, are therefore less likely to fall off.
  • the first connecting pipe 5 includes: a second ring cavity connecting section, one end is in communication with the third ring cavity 18, and the other end is connected to the negative pressure source section; the third ring cavity connecting section One end is in communication with the fourth annular chamber 19, and the other end is in communication with the negative pressure source section.
  • the second annular cavity connecting section and the third annular cavity connecting section are respectively connected to the second annular cavity 13 and the fourth annular cavity 19, and are passed through three parts under the action of negative pressure before administration.
  • the anchoring of the top surface 8 can more effectively restrain the second top surface 8 so that it cannot expand the protrusion outward, thereby avoiding weakening the adsorption force of the first ring chamber 4, and thus is not easy to fall off.
  • the method further includes: an annular pad 25 for preventing the skin 20 from being excessively stretched under the action of the negative pressure, and the skin 20 is damaged.
  • an annular pad 25 for preventing the skin 20 from being excessively stretched under the action of the negative pressure, and the skin 20 is damaged.
  • the annular pad 25 is permeable to the annular pad 25.
  • the annular pad 25 is disposed in the first annular cavity 4, and the skin 20 is stretched under the action of the negative pressure, but is placed on the annular pad 25 when the skin 20 is stretched to a certain extent, thereby avoiding excessive stretching of the skin 20.
  • the problem of damage to the skin 20 occurs.
  • the annular pad 25 can also be disposed in the second ring cavity 13 and fixed to one side wall or both side walls of the first ring cavity 4, or the annular pad 25 can also be One side is fixed with the first top surface 1 , that is, the annular pad 25 and the first top surface 1 are adhered by adhesive or the like; the annular pad 25 can also be fixed in the first annular cavity 4 by other means, but In this embodiment, the annular pad 25 can be an annular pad 25 with a venting hole, so that the skin 20 can be effectively lifted under the action of a negative pressure source.
  • the annular pad 25 can also be a cotton pad, a non-woven pad, etc., all of which can ensure the problem that the skin 20 is excessively stretched and the skin 20 is damaged under the premise of being breathable.

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  • Media Introduction/Drainage Providing Device (AREA)
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Abstract

一种经皮给药装置包括：第一顶面（1），设置在第一顶面（1）两侧并与第一顶面（1）一侧面固接的环形外壁（2）和环形内壁（3），第一顶面（1）、环形外壁（2）和环形内壁（3）组成第一环腔（4）；第一连接管（5），一端与第一环腔（4）连通，另一端与负压源连通；中央环腔（6），用于放置药物，包括第一环形壁（7）和第二顶面（8），且第一环形壁（7）通过第一环形底面（9）与环形内壁（3）—端连接；环形内壁（3）、第一环形底面（9）和第一环形壁（7）组成开口在第一顶面（1）方向上的第一环形槽（10）。该经皮给药装置通过第一环形槽（10）上端的张合适应曲率的变化，避免了第二顶面（8）对第一环腔（4）的牵制，使得贴服在不平整部位时不易脱落，解决了现有技术中外环腔由负压产生的吸附力减弱而使敷贴盘容易脱落的问题。

Description

一种经皮给药装置 技术领域
本发明涉及医疗器具领域，特别是指一种经皮给药装置。
背景技术
中国发明专利CN99126047.3，公开日2001年7月18日，发明创造名称为经皮给药仪，通过可以敷贴在皮肤表面的敷贴盘将药物加压渗透到皮肤内，发挥治疗作用。治疗时将敷贴盘置放在皮肤上，由于外环腔与负压源相通，外环腔由负压产生吸附力将其下的皮肤抬起，使敷贴盘吸附在皮肤上，同时使得中央腔得以完全密封，位于中央腔内的药物中的挥发成份不会逃逸到外部环境中。在实际应用过程中发现敷贴盘在一些情况下存在容易脱落的问题：
1、外环腔的顶面与中央腔的顶面是紧密相连而形成的同一平面或曲面。由于敷贴盘具有一定的厚度，顶面离皮肤具有一定距离，当敷贴盘敷贴在身体较为平整的部位时可敷贴得很牢固，但当敷贴盘敷贴在不平整的部位时，比如后颈、腿部、手臂等曲率较大部位时，敷贴盘的中央腔顶面会对相连的外环腔顶面产生很大的牵制力，削弱了外环腔由负压产生的吸附力，使敷贴盘容易脱落，影响治疗过程的正常进行。
2、在治疗过程中中央腔内空气温度在皮肤温度或/和外部热源加热下，温度逐步升高，其内的药物中的挥发性成分也逐步释放，使得中央腔内的压力逐步升高，促进了药物的经皮渗透。增大的压力也使得中央腔顶面受到背离皮肤表面方向而向外的抬升力，当压力较大时，会使顶面向外凸出，对相连的外环腔顶面产生很大的牵制力，削弱了外环腔由负压产生的吸附力，使敷贴盘容易脱落，影响治疗过程的正常进行。
3、在该技术方案中，真空管位于外环腔顶面。在治疗过程中，当真空管受到牵拉时，比如不小心碰到时，真空管所受的拉扯力会通过外环腔顶面直接传给环形外壁，减弱外环腔由负压产生的吸附力，使敷贴盘容易脱落，影响治疗过程的正常进行。
 技术问题
本发明提出一种经皮给药装置，解决了现有技术中削弱了外环腔由负压产生的吸附力，使敷贴盘容易脱落的问题。
技术解决方案
本发明的技术方案是这样实现的：
一种经皮给药装置，包括：
第一顶面，以及设置在第一顶面两侧并与第一顶面一侧面固接的环形外壁和环形内壁，第一顶面、环形外壁和环形内壁组成第一环腔；
第一连接管，一端与第一环腔连通，另一端与负压源连通；
中央环腔，用于放置药物；
所述中央环腔包括第一环形壁和第二顶面，且第一环形壁通过第一环形底面与环形内壁一端连接；
环形内壁、第一环形底面和第一环形壁组成开口在第一顶面方向上的第一环形槽。
优选的，还包括：第二环形壁、第三环形壁和第二环形底面；第二环形壁、第三环形壁和第二环形底面组成开口在第二顶面方向上的第二环形槽。
优选的，还包括：第四环形壁和第二连接管，第四环形壁和第二顶面组成第二环腔；第一环形壁、第四环形壁和第二顶面组成中央分环腔；第二连接管一端与第二环腔连通，另一端负压源连通。
优选的，还包括：连接柱，用于支撑第一连接管，设置在第二顶面上；第一连接管一端穿过连接柱与第一环腔连通，另一端与负压源连通。
优选的，第一连接管还包括：负压源连接段和第一环腔连接段；负压源连接段与第一环腔连接段连通，且第一环腔连接段一端与第一环腔连通，另一端与负压源连接段的连接处与第二环腔连通。
优选的，第一环腔连接段的长度大于第一环腔与第二环腔的水平状态下的直线距离。
优选的，还包括：第三环形壁和第四环形壁；第三环形壁和第二顶面组成第三环腔；第四环形壁和第二顶面组成第四环腔；且第二环腔、第三环腔和第四环腔等分设置在第二顶面上。
优选的，第一连接管包括：第二环腔连接段，一端与第三环腔连通，另一端与负压源段连通；第三环腔连接段，一端与第四环腔连通，另一端与负压源段连通。
优选的，还包括：环形垫，用于防止在负压的作用下拉伸皮肤过度，使皮肤受损，设置在第一环腔内。
优选的，环形垫透气环形垫。
 有益效果
本发明技术方案通过环形内壁、第一环形底面和第一环形壁组成的第一环形槽，当贴在身体表面曲率不同的不平整部位（如后颈、腿部、手臂）时，由于第一环形槽将第一顶面和第二顶面分隔开来，第一环形槽可以通过其上端的张合适应曲率的变化，从而避免第二顶面对第一环腔的牵制，所以使得贴服在不平整部位不易脱落；
另外，通过设有第二环腔，并通过第二连接管与负压源连通，能够使第二环腔附在皮肤上，从而减少其因其气体压力增大而使顶面向外凸出变形程度，所以不易脱落；
再者，由于通过连接柱固定在中央腔的顶面上，当第一连接管受到牵拉时，其作用力首先作用在第二顶面上，而第二顶面可通过相应的弹性变形来化解作用力，避免其直接传递到第一环腔上，从而避免其减弱第一环腔的吸附力，因此不易脱落。当采用负压源连接段和第一环腔连接段进行连接时，由于加在第一连接管的作用力施加在第二顶面上，可避免其减弱第一环腔的吸附力，因此不易脱落。
 附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本发明一种经皮给药装置一个实施例的结构示意图；
图2为本发明一种经皮给药装置另一个实施例的结构示意图；
图3为本发明一种经皮给药装置再一个实施例的结构示意图；
图4为本发明一种经皮给药装置再一个实施例的结构示意图；
图5为本发明一种经皮给药装置再一个实施例的结构示意图；
图6为本发明一种经皮给药装置再一个实施例的结构示意图；
图7为本发明一种经皮给药装置中中央环腔的一个实施例的结构示意图。
图中：
1、第一顶面；2、环形外壁；3、环形内壁；4、第一环腔；5、第一连接管；6、中央环腔；7、第一环形壁；8、第二顶面；9、第一环形底面；10、第一环形槽；11、第四环形壁；12、第二连接管；13、第二环腔；14、中央分环腔；15、连接柱；16、负压源连接段；17、第一环腔连接段；18、第三环腔；19、第四环腔；20、皮肤；21、第二环形壁；22、第三环形壁；23、第二环形底面；24、第二环形槽；25、环形垫。
 本发明的最佳实施方式
本发明的实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
如图1-7所示，本发明所述的一种经皮给药装置，包括：
第一顶面1，以及设置在第一顶面1两侧并与第一顶面1一侧面固接的环形外壁2和环形内壁3，第一顶面1、环形外壁2和环形内壁3组成第一环腔4；
第一连接管5，一端与第一环腔4连通，另一端与负压源连通；
中央环腔6，用于放置药物；
所述中央环腔（6）包括第一环形壁7和第二顶面8，且第一环形壁7通过第一环形底面9与环形内壁3一端连接；
环形内壁3、第一环形底面9和第一环形壁7组成开口在第一顶面1方向上的第一环形槽10。
通过环形内壁3、第一环形底面9和第一环形壁7组成的第一环形槽10，当贴在身体表面曲率不同的不平整部位（如后颈、腿部、手臂）时，由于第一环形槽10将第一顶面1和第二顶面8分隔开来，第一环形槽10可以通过其上端的张合适应曲率的变化，从而避免第二顶面8对第一环腔4的牵制，所以使得贴服在不平整部位不易脱落。
本发明的一个实施例中，通过第一顶面1、环形外壁2和环形内壁3组成的第一环腔4，其中，第一连接管5一端与第一环腔4连通，另一端与负压源连通，通过第一环形壁7和第二顶面8组成的中央环腔6，并且第一环形壁7与第一环形底面9一端连接，第一环形底面9的一端与环形内壁3连接，进而环形内壁3、第一环形底面9和第一环形壁7组成第一环形槽10；在使用阶段，第一环腔4和中央环腔6敷贴在皮肤20上，并将药物放置在中央环腔6内，负压源产生吸附力通过第一连接管5将皮肤20抬起，使第一环腔4吸附在皮肤20上，同时使中央环腔6得以完全密封，使得位于中央环腔6内的药物挥发后不会逃逸到外部环境中，且当敷贴在不平整部位时，第一环形槽10的开口端张开，间距增大，以适应不平整部位弯曲率的变化，这样就避免了第二顶面8对第一顶面1的牵制，避免削弱第一环腔4的吸附力，使得不易脱落。
如图5所示，本发明的另一个实施例中，优选的，还包括：第二环形壁21、第三环形壁22和第二环形底面23；第二环形壁21、第三环形壁22和第二环形底面23组成开口在第二顶面8方向上的第二环形槽24。
第二环形壁21与第二环形底面23一端连接，第三环形壁22与第二环形底面23的另一端连接，通过第二环形壁21、第二环形底面23和第三环形壁22组成第二环形槽24，当敷贴在弯曲程度较大的部位时，第二环形槽24配合第一环形槽10，两者看口端均张口，以使用弯曲程度较大部位的弯曲率，通过这样的设计进一步的避免削弱第一环腔4的吸附力，使得不易脱落。
如图2所示，本发明的另一个实施例中，优选的，还包括：第四环形壁11和第二连接管12，第四环形壁11和第二顶面8组成第二环腔13；第一环形壁7、第四环形壁11和第二顶面8组成中央分环腔14；第二连接管12一端与第二环腔13连通，另一端负压源连通。
第四环形壁11和第二顶面8组成的第二环腔13，且第二环腔13通过第二连接管12与负压源连通，通过第二环腔13，将中央环腔6分为中央分环腔14，本实施例中，第二连接管12可以单独与负压源连通，当然在使用第一连接管5的情况下也可以将第二连接管12与第一连接管5连通，再通过第一连接管5与负压源连通，通过这种方式可以在一定程度上节约制造成本，具体情况以实际的使用需求而定，本发明中对此不作进一步的限定；使用阶段，在负压源的作用下通过第二连接管12将第二环腔13下的皮肤20吸附住，即对第二顶面8的中心部进行了锚定，使得其在气体膨胀或压力逐步增大情况下不会向外膨胀凸起，避免削弱第一环腔4的吸附力，因此不易脱落。
如图3所示，本发明的再一个实施例中，优选的，还包括：连接柱15，用于支撑第一连接管5，设置在第二顶面8上；第一连接管5一端穿过连接柱15与第一环腔4连通，另一端与负压源连通。
本实施例中，第二顶面8上增设一与其固结的连接柱15，第一连接管5一端穿过连接柱15并固定在该连接柱15上，第一连接管5穿过连接柱15的一端与第一环腔4连通，且穿过连接柱15端的第一连接管5的长度大于第一顶面1处于水平衡状态时中心点与第一环腔4中心点之间的直线距离，即当第二顶面8为水平展状态时，第一连接管5是弯曲的，而当敷贴在身体曲率较大的部位时，第一连接管5的长度可以适应这种增大了的距离，不会对第一顶面1形成牵制；同时，由于第一连接管5通过连接柱15固定在第二顶面8上，当第一连接管5受到牵拉时，其作用力首先作用第二顶面8上，而第二顶面8能够通过相应的弹性变形来化解作用力，避免其直接传递到第一顶面1上，从而避免其减弱第一环腔4的吸附力，因此不易脱落。
优选的，第一连接管5还包括：负压源连接段16和第一环腔连接段17；负压源连接段16与第一环腔连接段17连通，且第一环腔连接段17一端与第一环腔4连通，另一端与负压源连接段16的连接处与第二环腔13连通。
优选的，第一环腔连接段17的长度大于第一环腔4与第二环腔13的水平状态下的直线距离。
如图4所示，本发明的再一实施例中，第一连接管5包括负压源连接段16和第一环腔连接段17，第一环腔连接段17与第一环腔4连通，第一环腔连接段17和负压源连接段16的连接处与第二环腔13连通，其中，第一环腔连接段17的长度大于第一环腔4与第二环腔13的水平状态下的直线距离，当敷贴在身体曲率较大的部位时，第一环腔连接段17可以有足够的长度来适应其两端距离的增大，避免第一顶面1受到牵制，同时，在负压源的作用下通过第一连接管5将第二环腔13下的皮肤20吸附住，即对第二顶面8的中心部进行了锚定，使得其在气体膨胀，压力逐步增大情况下不会向外膨胀凸起，避免削弱第一环腔4的吸附力，因此不易脱落。
优选的，还包括：第三环形壁22和第四环形壁11；第三环形壁22和第二顶面8组成第三环腔18；第四环形壁11和第二顶面8组成第四环腔19；且第二环腔13、第三环腔18和第四环腔19等分设置在第二顶面8上。
如图7所示，本发明的再一个实施例中，通过第三环形壁22和第二顶面8组成第三环腔18，第四环形壁11和第二顶面8组成第四环腔19，且第二环腔13、第三环腔18和第四环腔19等分设置在第二顶面8上，在本发明中设置个环腔为优选的技术方案，为避免第二顶面8不能向外膨胀凸起，可以设置4个、5个或更多的环腔，为节省篇幅本实施例中对此不作限定，在本实施例中，第二顶面8内设置有环形通道将第二环腔13、第三环腔18和第四环腔19连通，通过3个部位对第二顶面8进行锚定，能够更加有效的约束第二顶面8，使其不能向外膨胀凸起，进而避免削弱第一环腔4的吸附力，因此不易脱落。
本发明的再一个实施例中，优选的，第一连接管5包括：第二环腔连接段，一端与第三环腔18连通，另一端与负压源段连通；第三环腔连接段，一端与第四环腔19连通，另一端与负压源段连通。
本实施例中，通过第二环腔连接段和第三环腔连接段分别与第二环腔13和第四环腔19连通，在给药前在负压的作用下通过3个部位对第二顶面8进行锚定，能够更加有效的约束第二顶面8，使其不能向外膨胀凸起，进而避免削弱第一环腔4的吸附力，因此不易脱落。
如图6所示，本发明的再一个实施例中，优选的，还包括：环形垫25，用于防止在负压的作用下拉伸皮肤20过度，使皮肤20受损，设置在第一环腔4内。
优选的，环形垫25透气环形垫25。
环形垫25设置在第一环腔4内，当在负压的作用下皮肤20被拉伸，但当皮肤20拉伸到一定程度时顶在环形垫25上，因此避免了皮肤20拉伸过度对皮肤20造成损坏的问题出现，环形垫25还可以设置在第二环腔13内，并与第一环腔4的一侧壁或两侧壁固结在一起，也可以将环形垫25的一面与第一顶面1固结在一起，即将环形垫25与第一顶面1通过黏胶等贴合在一起；环形垫25还可以通过其他的方式固定在第一环腔4中，但为节省篇幅本实施例中对此不再赘述；本实施例中环形垫25上具体可以为带透气孔的环形垫25，这样才能够有效的在负压源的作用下将皮肤20抬起，当然环形垫25还可以为棉垫、无纺布垫等，均可以保证透气的前提下，避免了皮肤20拉伸过度对皮肤20造成损坏的问题出现。
以上仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
 工业实用性
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Claims (1)

1、一种经皮给药装置，包括：
第一顶面（1），以及设置在所述第一顶面（1）两侧并与所述第一顶面（1）一侧面固接的环形外壁（2）和环形内壁（3），所述第一顶面（1）、所述环形外壁（2）和所述环形内壁（3）组成第一环腔（4）；
第一连接管（5），一端与所述第一环腔（4）连通，另一端与负压源连通；中央环腔（6），用于放置药物；
其特征在于，
所述中央环腔（6）包括第一环形壁（7）和第二顶面（8），且所述第一环形壁（7）通过第一环形底面（9）与所述环形内壁（3）一端连接；
所述环形内壁（3）、所述第一环形底面（9）和所述第一环形壁（7）组成开口在第一顶面（1）方向上的第一环形槽（10）。
2、如权利要求1所述的经皮给药装置，其特征在于，还包括：
第二环形壁（21）、第三环形壁（22）和第二环形底面（23）；
所述第二环形壁（21）、所述第三环形壁（22）和所述第二环形底面（23）组成开口在第二顶面（8）方向上的第二环形槽（24）。
3、如权利要求1所述的经皮给药装置，其特征在于，还包括：
第四环形壁（11）和第二连接管（12），所述第四环形壁（11）和所述第二顶面（8）组成第二环腔（13）；
所述第一环形壁（7）、所述第四环形壁（11）和所述第二顶面（8）组成中央分环腔（14）；
所述第二连接管（12）一端与所述第二环腔（13）连通，另一端负压源连通。
4、如权利要求1所述的经皮给药装置，其特征在于，还包括：
连接柱（15），用于支撑所述第一连接管（5），设置在所述第二顶面（8）上；
所述第一连接管（5）一端穿过所述连接柱（15）与所述第一环腔（4）连通，另一端与负压源连通。
5、如权利要求3所述的经皮给药装置，其特征在于，所述第一连接管（5）还包括：
负压源连接段（16）和第一环腔连接段（17）；
所述负压源连接段（16）与所述第一环腔连接段（17）连通，且所述第一环腔连接段（17）一端与所述第一环腔（4）连通，另一端与所述负压源连接段（16）的连接处与所述第二环腔（13）连通。
6、如权利要求5所述的经皮给药装置，其特征在于，所述第一环腔连接段（17）的长度大于所述第一环腔（4）与所述第二环腔（13）的水平状态下的直线距离。
7、如权利要求6所述的经皮给药装置，其特征在于，还包括：
第三环形壁（22）和第四环形壁（11）；
所述第三环形壁（22）和所述第二顶面（8）组成第三环腔（18）；所述第四环形壁（11）和所述第二顶面（8）组成第四环腔（19）；且所述第二环腔（13）、所述第三环腔（18）和所述第四环腔（19）等分设置在所述第二顶面（8）上。
8、如权利要求7所述的经皮给药装置，其特征在于，所述第一连接管（5）包括：
第二环腔连接段，一端与所述第三环腔（18）连通，另一端与所述负压源段连通；
第三环腔连接段，一端与所述第四环腔（19）连通，另一端与所述负压源段连通。
9、如权利要求1至8任一项所述的经皮给药装置，其特征在于，还包括：环形垫（25），用于防止在负压的作用下拉伸皮肤（20）过度，使皮肤（20）受损，设置在所述第一环腔（4）内。
10、如权利要求9所述的经皮给药装置，其特征在于，所述环形垫（25）具体为透气环形垫（25）。
PCT/CN2013/089618 2013-03-22 2013-12-17 一种经皮给药装置 WO2014146464A1 (zh)

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JP2015558334A JP6205434B2 (ja) 2013-03-22 2013-12-17 経皮的薬剤配達装置
US14/655,641 US10052466B2 (en) 2013-03-22 2013-12-17 Transdermal drug delivering device
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EP2977076C0 (en) 2023-08-09
JP2016507310A (ja) 2016-03-10
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