WO2014146057A3 - Mesenchymal stem cells - Google Patents

Mesenchymal stem cells Download PDF

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Publication number
WO2014146057A3
WO2014146057A3 PCT/US2014/030935 US2014030935W WO2014146057A3 WO 2014146057 A3 WO2014146057 A3 WO 2014146057A3 US 2014030935 W US2014030935 W US 2014030935W WO 2014146057 A3 WO2014146057 A3 WO 2014146057A3
Authority
WO
WIPO (PCT)
Prior art keywords
pluripotent
stem cells
cells
mesenchymal stem
derived
Prior art date
Application number
PCT/US2014/030935
Other languages
French (fr)
Other versions
WO2014146057A2 (en
Inventor
Diane Rudy-Reil
Original Assignee
Cmr Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cmr Technologies, Llc filed Critical Cmr Technologies, Llc
Publication of WO2014146057A2 publication Critical patent/WO2014146057A2/en
Publication of WO2014146057A3 publication Critical patent/WO2014146057A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

As defined in the art, "pluripotent stem cells" and "pluripotent cells" refer to human embryonic stem cells (e.g., hESC) or human pluripotent cells derived from non-pluripotent sources (e.g., iPSC). "Pluripotent cells" are capable of differentiating to one or more lineages derived from all three primary germ layers and it is anticipated that virtually any pluripotent stem cell line or clone that meets the defining criteria of pluripotency may be used with the present invention.
PCT/US2014/030935 2013-03-15 2014-03-18 Mesenchymal stem cells WO2014146057A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361793933P 2013-03-15 2013-03-15
US61/793,933 2013-03-15

Publications (2)

Publication Number Publication Date
WO2014146057A2 WO2014146057A2 (en) 2014-09-18
WO2014146057A3 true WO2014146057A3 (en) 2015-10-29

Family

ID=51538606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/030935 WO2014146057A2 (en) 2013-03-15 2014-03-18 Mesenchymal stem cells

Country Status (1)

Country Link
WO (1) WO2014146057A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090045886A (en) 2006-04-14 2009-05-08 어드밴스드 셀 테크놀로지, 인코포레이티드 Hemangio-colony forming cells
CN115087730A (en) * 2019-11-28 2022-09-20 香港大学 Mesenchymal stromal cells as IPSC-induced reprogramming source

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617159B1 (en) * 1998-11-09 2003-09-09 Consorzio Per La Gestione Del Centro Di Biotechnologie Avanzate Serum free medium for chondrocyte cells
US20100184212A1 (en) * 2007-05-30 2010-07-22 Steven Stice Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
US8110400B2 (en) * 2005-03-03 2012-02-07 Roslin Foundation Culture of mammalian pluripotent stem cells in the presence of hyaluronan induces differentiation into multi-lineage progenitor cells
US20120213748A1 (en) * 2007-03-15 2012-08-23 Gabriel Nistor Cardiomyocytes and methods of producing and purifying cardiomyocytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617159B1 (en) * 1998-11-09 2003-09-09 Consorzio Per La Gestione Del Centro Di Biotechnologie Avanzate Serum free medium for chondrocyte cells
US8110400B2 (en) * 2005-03-03 2012-02-07 Roslin Foundation Culture of mammalian pluripotent stem cells in the presence of hyaluronan induces differentiation into multi-lineage progenitor cells
US20120213748A1 (en) * 2007-03-15 2012-08-23 Gabriel Nistor Cardiomyocytes and methods of producing and purifying cardiomyocytes
US20100184212A1 (en) * 2007-05-30 2010-07-22 Steven Stice Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions

Also Published As

Publication number Publication date
WO2014146057A2 (en) 2014-09-18

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