WO2014140566A1 - Magnetic detector - Google Patents
Magnetic detector Download PDFInfo
- Publication number
- WO2014140566A1 WO2014140566A1 PCT/GB2014/050731 GB2014050731W WO2014140566A1 WO 2014140566 A1 WO2014140566 A1 WO 2014140566A1 GB 2014050731 W GB2014050731 W GB 2014050731W WO 2014140566 A1 WO2014140566 A1 WO 2014140566A1
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- WO
- WIPO (PCT)
- Prior art keywords
- coils
- probe
- coil
- sense
- drive
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/065—Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/0213—Measuring direction or magnitude of magnetic fields or magnetic flux using deviation of charged particles by the magnetic field
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V3/00—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation
- G01V3/08—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices
- G01V3/10—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices using induction coils
- G01V3/104—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices using induction coils using several coupled or uncoupled coils
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
Definitions
- the invention relates generally to the field of medical devices for locating tissue in preparation for surgery and more specifically for detecting magnetic markers in tissue for excision.
- the inventors of the sensor probes for these systems seek to improve the design by: reducing thermal effects which cause coils in the sensor to shift with respect to one another and reduce the ability of the user to detect the signal from the magnetic nanoparticles; reducing interference caused by diamagnetic responses due to the body itself; and reducing the interference caused by eddy currents induced in objects near the sensor probe. In addition, it is desired that all these functional improvements be accomplished using a smaller sized probe with heightened sensitivity.
- the invention relates to a probe for detecting a magnetic marker.
- the probe includes a probe core having a first end and a second end, the probe core defining two regions for containing coils of wire, one of the regions being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the regions; and two drive coils, one each of the drive coils being located in a respective one of the regions, wherein the regions are separated by a distance equal to or greater than the diameter of one of the coils.
- the magnetic marker comprises magnetic nanoparticles.
- one of the set of two drive coils and the set of two sense coils is connected as a gradiometer, and the other of the set of two drive coils and the set of two sense coils is connected in series.
- the regions of the probe core define two channels for containing coils of wire, one of the channels being adjacent the first end of the cylindrical probe core, wherein one each of the sense coils being located in a respective one of the channels, wherein one each of the drive coils being co-located with the respective sense coil in a respective one of the channels, wherein the drive coils are connected in series, and wherein the sense coils are connected in anti-series.
- the drive coil is wound on top of the sense coil.
- the regions of the probe core define two channels for containing coils of wire, one of the channels being adjacent the first end of the cylindrical probe core, wherein one each of the sense coils being located in a respective one of the channels, wherein one each of the drive coils being co-located with the respective sense coil in a respective one of the channels, wherein the drive coils are connected in anti-series, and wherein the sense coils are connected in series.
- the regions of the probe define four channels for containing coils of wire, a respective two of the channels being located in each of the respective regions, wherein two of the channels are located adjacent the first end of the cylindrical probe core, wherein one each of the sense coils being located in a respective one of the channels in each one of the regions, wherein one each of the drive coils being located in a respective one of the channel in each one of the regions, wherein no two coils occupy the same channel, wherein the drive coils are connected in series, and wherein the sense coils are connected in anti-series.
- the regions of the probe define four channels for containing coils of wire, a respective two of the channels being located in each of the respective regions, wherein two of the channels are located adjacent the first end of the cylindrical probe core, wherein one each of the sense coils being located in a respective one of the channels in each one of the regions, wherein one each of the drive coils being located in a respective one of the channel in each one of the regions, wherein no two coils occupy the same channel, wherein the drive coils are connected in anti-series, and wherein the sense coils are connected in series.
- the order of the coils from the first end toward the second end of the probe is sense coil, drive coil, sense coil, and drive coil.
- the order of the coils from the first end toward the second end of the probe is drive coil, sense coil, drive coil, and sense coil.
- the order of the coils from the first end toward the second end of the probe is sense coil, drive coil, drive coil, and sense coil.
- the order of the coils from the first end toward the second end of the probe is drive coil, sense coil, sense coil, and drive coil.
- the sense coils and the drive coils have different diameters.
- the sense coils and the drive coils have different numbers of turns.
- the probe further includes a third drive coil, the third drive coil in series connection between the first and the second drive coil and positioned between the first and second drive coil so as to form a single solenoidal drive coil, wherein one each of the sense coils being located near a respective end of the single solenoidal drive coil.
- every turn of the single solenoidal drive coil is of the same diameter.
- the longitudinal center turn of the single solenoidal drive coil has a greater diameter than turns on the ends of the solenoidal drive coil.
- every turn of the single solenoidal drive coil is of the same spacing.
- turns in the longitudinal center of the single solenoidal drive coil have a greater spacing than turns on the ends.
- the probe core comprises a material with a thermal diffusivity of substantially > 20 x 10 "6 m 2 /s and a thermal expansion coefficient of substantially ⁇ 3 x 10 "5 /°C. US Attorney Docket No. END-005
- the probe core comprises a material that has a thermal diffusivity of substantially > 50 x 10 "6 m 2 /s and a thermal expansion coefficient of substantially ⁇ 5xlO ⁇ VC.
- FIG. 1 is a block diagram of an embodiment of a probe constructed in accordance with the invention.
- FIG. 2 is a block diagram of another embodiment of a probe constructed in accordance with the invention.
- FIG. 3 is a cross-sectional diagram of the embodiment of the probe of Fig. 2;
- FIG. 4 is a block diagram of another embodiment of a probe using a solenoid coil constructed in accordance with the invention.
- Figs. 5 (a-d) are cross-sections of four solenoid coil configurations
- Fig. 6a is a cross section of a solenoidal coil with additional coils on each end;
- Fig. 6b is a graph of the field generated by the solenoidal coil of Fig. 6a;
- Fig. 7 is a cross-sectional representation of a Helmholtz coil embodiment
- Fig. 8 is a graph of the modulation of a primary magnetic field with a secondary magnetic field and the resulting frequency spectrum
- Fig. 9 is an embodiment of a secondary field generator for use in creating the secondary magnetic field shown in Fig. 8; US Attorney Docket No. END-005
- Fig. 10 is an embodiment of a secondary field generator for use in creating the secondary magnetic field shown in Fig. 8;
- FIGS 11 and 12 provide tables 1 and 2 respectively, which are referred to in the description below.
- the material preferably has a thermal diffusivity of substantially > 20 x 10 "6 m 2 /s and a thermal expansion coefficient of substantially ⁇ 3 x 10 "5 /°C. More preferably, the material has a thermal diffusivity of substantially > 50 x 10 "6 m 2 /s and a thermal expansion coefficient of substantially ⁇ 5xl0 "6 /°C.
- Such materials may include: US Attorney Docket No. END-005
- Glassy ceramics such as borosilicate based machinable ceramics e.g. Macor® (Corning Inc, New York);
- Non-glassy ceramics such as aluminum nitride, boron nitride, silicon carbide;
- Composite ceramics such as Shapal-M, a composite of boron nitride and aluminum nitride (Tokuyama Corporation, Shunan City, Japan); and
- Carbon- and glass-filled composites for example glass or carbon filled
- PEEK Polyetheretherketone
- the material has a high stiffness to avoid change in the position of the coils due to mechanical deformation.
- the material has a Young's Modulus of > 40GPa and preferably > 80GPa, and the material has as high a toughness as can be achieved given the other material constraints.
- the likely failure mode is energy- (or shock-) induced brittle fracture, for example when the probe is knocked or dropped.
- the relevant material property is the toughness Gi C ⁇ Kj C /E (KJm ⁇ ) which, along with other probe information, is tabulated in Table 2.
- the probe's sensitivity to temperature changes is further reduced by minimizing heat transfer into the probe from outside of the probe. This is achieved by using a high conductivity polymer material for the case, so that the inside surface of the case is closer to an isothermal surface, thus minimizing thermal gradients inside the probe and providing an insulating layer of air or a highly insulating material such as aerogel or a vacuum gap around the probe core, or former, and windings.
- the coil configurations may be selected to reduce thermal effects.
- the probe includes a coil former with two sense coils and two drive coils.
- the sense and drive coils are arranged in two pairs, each consisting of one sense coil and one drive coil in close proximity to one another.
- the probe's magnetic sensing performance is maximized by locating one sense and drive coil pair close to the sensing tip of the probe, and locating the second pair of coils an axial distance away from the first pair of coils.
- the distance is preferably greater than the diameter of the smallest coil, and more preferably greater than the diameter of the largest coil in the pair.
- the diameter of the largest coil is 15mm, and in another embodiment, the diameter is 12mm.
- END-005 pair of coils is arranged such that the voltage induced in each of the sense coils by the field generated by the drive coils is approximately equal and opposite.
- the sense coils are arranged as a first order gradiometer in order to minimize the effect of far field sources.
- the coils 10, 10', 16, 16' are co-located such that each drive coil 10, 10' is co-located with a sense coil 16, 16'. Either order of the arrangement of the sense and drive coils can be used.
- the drive coil is wound on top of the sense coil in order to minimize any effect from thermal expansion of the drive coils as the drive coils warm due to ohmic heating. This arrangement is useful where thermal effects are less important than sensitivity at very small diameters (e.g. ⁇ 15mm).
- this arrangement does not require specific diameters and spacing of the drive and sense coils, it is suitable for use in probes of a very small outer diameter.
- this probe has a diameter of less than 15mm or even less than 10mm in diameter.
- drive 10, 10' and sense 16, 16' coils are staggered with the drive coils 10, 10' being separated and the sense coils 16, 16' are divided into two parts.
- the spacing of the drive coil relative to the sense coil in each pair is chosen such that the effects of the expansion of the larger of the two coils on the mutual inductance of the pair of coils is minimized. This helps further to minimize the effect of thermal expansion.
- This arrangement provides improved sensing because the sensitivity drops off more slowly with distance.
- the sense coil is closest to the sensing end of the probe in order to maximize sensing distance.
- the coil order is SD - SD where D represents a drive coil and S represents a sense coil.
- a cross-section of an embodiment of a probe 20 is shown including a housing 24, temperature barrier 26 and a coil former or probe core 30 having circumferential grooves 28 into which the coils 10, 10', 16. 16' are formed.
- a higher order gradiometer can be used for either set of coils, providing that in each case the order of gradiometer of the drive set of coils differs by one from the order of gradiometer of the sense set of coils.
- the sense coils may form a second order gradiometer and the drive coils may form a first (or third) order gradiometer.
- the winding is arranged together with the electronic circuit such that the outside layer of the coil winding is close to ground potential of the electronics. This minimizes the capacitive coupling between the probe and the patient's body which is assumed to be at ground potential.
- Further embodiments include making the sense coil the larger of the two diameters (rather than the drive coil) in combination with any of the above. If a smaller gauge wire is used for the sense coil (as it carries only a tiny current), then making the sense coil the larger of the two is advantageous because it allows the average diameters of the drive and sense coils to be maximized within the specific arrangement of the sense coil/drive coil pairs. Increasing the diameter and therefore the areas of the coils increases the sensitivity of the magnetic sensor. A larger gauge of wire may be used for the drive coil in order to minimize ohmic heating.
- the magnetic sensitivity is commensurately reduced by a factor of r 4 in the near field (drive field drops off with r 2 and sensing capability with r 2 ) and r 6 in the far field. Therefore, in order to maintain a similar level of magnetic sensitivity in a smaller diameter probe, the number of turns in the coils, particularly in the sense coils, is increased. However, as a side effect, this also magnifies any noise or drift by the same factor. Thus, drift due to changes in the coil geometry caused by temperature changes should be expected to be magnified.
- the thermal drift due to warm body contact can be maintained at an acceptable level.
- the signal change in response to US Attorney Docket No. END-005 contact with a warm body at 37°C is about 86% of the equivalent signal change in one of the prior art systems. Because the smaller probe has twice as many coil turns, the signal change should therefore be much greater than this.
- a solenoid 31 is used as the excitation (drive) coil and two sense coils 34 are positioned inside the solenoid 31.
- the sense coils 34 are not too close to the end of the solenoid 31 , they will experience a substantially uniform magnetic field from the solenoid 31.
- the benefit of this arrangement is that small movements relative to the solenoid 31 , for example due to thermal expansion, will not disturb the (magnetic) balance of the sense coils 34.
- the solenoid will also provide an additional heat conduction path to the sense coils and the coil core to help equalize temperature across all the coils. By choosing the wire gauge, the ohmic heating effect of the solenoid can be minimized.
- the solenoid coil also forms an electrostatic shield for the sense coil.
- the uniformity of the field at the ends of the solenoid is optimized by appropriate design of the coils, for example, by varying the spacing, the diameter, both the spacing and diameter, or the shape of the solenoid coils (Fig. 5 (a-d)). Design and manufacturing of such solenoids is known to those skilled in the art.
- FIG. 6a A particular example is shown in Fig. 6a, together with a graph (Fig. 6b), showing the results of modeling the resulting normalized magnetic field strength.
- the solenoid drive coil is one in which the drive coil is formed from a Helmholtz pair of coils where the separation between the coils, 1, is substantially equal to the radius of the coils (r) (Fig. 7).
- the Helmholtz coil is a well-known arrangement that provides a region of constant magnetic field between the two coils, and this region extends further than in any other arrangement of the coils with a different ratio of separation-to-radius.
- a further embodiment addresses the issue of distinguishing between the signal from the iron oxide US Attorney Docket No. END-005 nanoparticles and the signals from other metallic objects.
- a second varying magnetic drive field is generated at a lower frequency than the primary drive field and with comparable or greater magnitude than the primary drive field.
- the secondary drive field modulates the susceptibility of the magnetic nanoparticles and creates additional frequency components in the spectrum received by the sense coils at frequencies fo ⁇ 2nfi, where fo is the primary drive field frequency and fi is the secondary drive field frequency and n is a whole number (Fig. 8).
- the presence of magnetic nanoparticles can be detected by analyzing these additional frequencies that are a result of the mixing of the primary and secondary drive frequencies.
- the amplitude of the side lobe at fo ⁇ 2fi is measured to detect the presence of magnetic nanoparticles.
- the ratio of the amplitude A f o+2fi of the side lobe to the amplitude A f o of the fundamental is measured.
- Other embodiments are possible that result in an advantageous combination of frequencies. These components are less sensitive or even insensitive to coil structure and geometric imbalance, temperature effects, and also to eddy currents. Thus, by appropriate signal processing, the undesirable disturbance from coil structure and geometric imbalance, temperature sensitivity, and metallic objects can be reduced or eliminated.
- the drive field from the probe will induce eddy currents in any electrically conducting object, e.g. metallic surface that is sufficiently close, and the magnetic field created by the eddy currents may then be picked up by the sense coils as an extraneous signal.
- any electrically conducting object e.g. metallic surface that is sufficiently close
- the magnetic field created by the eddy currents may then be picked up by the sense coils as an extraneous signal.
- the mixed or modulated frequencies fo ⁇ 2nfi do not show any component of fields generated by eddy currents, which means that non-ferromagnetic materials can be distinguished from nanoparticles.
- these fi frequency components can be used to detect the presence of the nanoparticles and distinguish them from non-ferromagnetic materials.
- the existence of side lobes are indicative of nanoparticles and one such measure of the presence of nanoparticles is obtained by measuring the amplitude of the side lobe.
- it is possible to normalize the measurement of the presence of nanoparticles by using the ratio of the amplitude A f o+ ⁇ n of a side lobe to the amplitude A f o of the fundamental (A f o ⁇ 2 nf i / A f o) where n is a whole number.
- the primary drive frequency can be increased to take advantage of the increased sensitivity of the magnetic nanoparticles at higher frequencies.
- the frequency could be increased to significantly more than 10kHz; e.g., to 50kHz or 100kHz or 250kHz or more.
- ferromagnetic materials will exhibit both eddy current and magnetic responses, and have similar non-linear magnetic properties to the nanoparticles. Hence, the magnetic part of the response is not readily distinguishable from the magnetic nanoparticles.
- the magnetic nanoparticles have a non-linear frequency response, the response of the particles can be distinguished from the diamagnetic effect of the body, which has a linear effect. Therefore, the present invention can also be used to screen out the diamagnetic effect.
- a secondary drive field is suitable for use with any of the coil embodiments and, for any given embodiment, the detection of the magnetic field will be much less sensitive to imbalances in the coils.
- This system does not require a balanced coil arrangement, provided that the fundamental frequency can be filtered out effectively, although practically this may be desirable for other reasons, e.g. to avoid saturating the input electronics.
- the frequency of the secondary drive field is chosen to provide sufficient frequency separation from the primary drive frequency band. This may be, for example, in the region of 0.5% to 10% of the primary frequency and preferably in the range of 1% to 5%.
- a primary frequency of 100kHz a secondary frequency of 10Hz to 10kHz, and more preferably between 100Hz and 1kHz, could be used.
- the primary frequency is 100kHz and the secondary 1kHz.
- the secondary frequency may be chosen to be a multiple of the power supply frequency, e.g. n x 50 or n x 60Hz, such that the secondary drive can be derived from power supply frequency, but the power supply frequency does not interfere with the sensing.
- the primary frequency may be 10kHz and the secondary frequency 200Hz.
- a resonant drive circuit may be used for generating the primary field to maximize the magnetic field strength for a given level of power input.
- a secondary field strength in the region of interest of at least 15 microTesla, and preferably greater than 25 microTesla, is appropriate.
- the secondary field is generated by the handheld probe containing the sensing and primary drive fields, for example, by having a moving permanent magnet.
- the movement of the magnet can be for example an oscillatory, rotating or vibratory movement.
- an additional coil is added to the probe and is driven so as to create a time varying magnetic field.
- the secondary field is generated away from the probe for example by means of a device placed near to the patient.
- the field is generated in a pad that sits underneath or adjacent to the area of the patient that is being sensed.
- the field is generated by a coil or multiple coils arranged so as to US Attorney Docket No. END-005 create a suitable secondary magnetic field.
- a coil diameter of at least 200mm is desirable and a field strength of 2.5mT (or H field of 2000 A/m) are desirable at the center of the coil so that there is sufficient secondary field strength in the region of interest where the probe will be used.
- an alternating secondary field can be generated by rotating a permanent magnet 50, 50' using a motor 54 rotating at the desired frequency.
- the rotating permanent magnet has the advantage that it is contained within the handheld probe.
- Such a small motor 54 is capable of spinning a rare earth magnet 50 such that the magnetic polarity of the magnet changes with each rotation.
- the secondary field may be generated electromagnetically by a drive coil 60 located at the rear of the handheld probe driven by a signal generator.
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- General Life Sciences & Earth Sciences (AREA)
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Abstract
Description
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Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2015012590A MX2015012590A (en) | 2013-03-13 | 2014-03-12 | Magnetic detector. |
CN201480025724.XA CN105188529B (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
AU2014229834A AU2014229834B2 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
CA2905313A CA2905313C (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
EP14710949.0A EP2967428B1 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
BR112015022603-5A BR112015022603B1 (en) | 2013-03-13 | 2014-03-12 | MAGNETIC DETECTOR |
JP2015562308A JP6799919B2 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
AU2018203954A AU2018203954B2 (en) | 2013-03-13 | 2018-06-05 | Magnetic detector |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/799,480 US9239314B2 (en) | 2013-03-13 | 2013-03-13 | Magnetic detector |
US13/799,334 | 2013-03-13 | ||
US13/799,480 | 2013-03-13 | ||
US13/799,334 US9234877B2 (en) | 2013-03-13 | 2013-03-13 | Magnetic detector |
Publications (1)
Publication Number | Publication Date |
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WO2014140566A1 true WO2014140566A1 (en) | 2014-09-18 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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PCT/GB2014/050732 WO2014140567A2 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
PCT/GB2014/050731 WO2014140566A1 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/GB2014/050732 WO2014140567A2 (en) | 2013-03-13 | 2014-03-12 | Magnetic detector |
Country Status (7)
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EP (2) | EP2967428B1 (en) |
JP (2) | JP6799919B2 (en) |
CN (1) | CN105188529B (en) |
AU (2) | AU2014229834B2 (en) |
CA (1) | CA2905313C (en) |
MX (1) | MX2015012590A (en) |
WO (2) | WO2014140567A2 (en) |
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WO2018039672A1 (en) | 2016-08-26 | 2018-03-01 | Musc Foundation For Research Development | Metal clip detectors and methods of detection |
WO2023079293A1 (en) | 2021-11-03 | 2023-05-11 | Endomagnetics Ltd. | Improvements in or relating to implantable ferromagnetic markers |
WO2023079292A1 (en) | 2021-11-03 | 2023-05-11 | Endomagnetics Ltd. | Magnetic markers for imaging and surgical guidance |
WO2023079288A1 (en) | 2021-11-03 | 2023-05-11 | Endomagnetics Ltd. | Improvements in or relating to implantable ferromagnetic markers |
WO2023194728A1 (en) * | 2022-04-05 | 2023-10-12 | Endomagnetics Ltd | Improvements in or relating to susceptibility probes for detecting surgical markers |
WO2023194727A1 (en) * | 2022-04-05 | 2023-10-12 | Endomagnetics Ltd | Improvements in or relating to susceptibility probes for detecting surgical markers |
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GB2582123B (en) | 2018-01-25 | 2021-04-28 | Endomagnetics Ltd | Systems and methods for detecting magnetic markers for surgical guidance |
GB2573500B (en) | 2018-03-23 | 2020-11-04 | Endomagnetics Ltd | Magnetic markers for surgical guidance |
GB201905988D0 (en) | 2019-04-29 | 2019-06-12 | Endomagnetics Ltd | Novel detection system using probes |
CN110456419A (en) * | 2019-08-27 | 2019-11-15 | 刘卫军 | A kind of electromagnetic excitation response signal mutual-inductance apparatus and detection device and detection method |
GB2595858B (en) | 2020-06-08 | 2022-06-22 | Endomagnetics Ltd | Systems and methods for detecting magnetic markers for surgical guidance |
GB2596833A (en) | 2020-07-08 | 2022-01-12 | Endomagnetics Ltd | Systems and methods for detecting markers for surgical guidance |
GB2598603B (en) | 2020-09-04 | 2023-02-15 | Endomagnetics Ltd | Systems and methods for detecting magnetic markers for surgical guidance |
JPWO2023042265A1 (en) * | 2021-09-14 | 2023-03-23 | ||
EP4167255A1 (en) * | 2021-10-14 | 2023-04-19 | Premo, S.A. | Thermal conductive bobbin for a magnetic power unit |
KR102669537B1 (en) * | 2023-05-24 | 2024-05-24 | 동국대학교 와이즈캠퍼스 산학협력단 | Ferrous wear sensor |
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JP2019095462A (en) | 2019-06-20 |
EP2967428A1 (en) | 2016-01-20 |
EP2967428B1 (en) | 2019-05-29 |
JP2016517289A (en) | 2016-06-16 |
AU2018203954B2 (en) | 2020-01-30 |
WO2014140567A3 (en) | 2014-11-27 |
MX2015012590A (en) | 2016-06-02 |
EP2972514B1 (en) | 2020-12-23 |
CA2905313A1 (en) | 2014-09-18 |
WO2014140567A2 (en) | 2014-09-18 |
CN105188529B (en) | 2019-05-07 |
JP6799919B2 (en) | 2020-12-16 |
AU2014229834B2 (en) | 2018-03-08 |
CN105188529A (en) | 2015-12-23 |
EP2972514A2 (en) | 2016-01-20 |
AU2014229834A1 (en) | 2015-09-24 |
AU2018203954A1 (en) | 2018-06-28 |
CA2905313C (en) | 2020-09-22 |
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