WO2014133541A3 - Method and system for treatment of cardiovascular disorders - Google Patents
Method and system for treatment of cardiovascular disorders Download PDFInfo
- Publication number
- WO2014133541A3 WO2014133541A3 PCT/US2013/028579 US2013028579W WO2014133541A3 WO 2014133541 A3 WO2014133541 A3 WO 2014133541A3 US 2013028579 W US2013028579 W US 2013028579W WO 2014133541 A3 WO2014133541 A3 WO 2014133541A3
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- WO
- WIPO (PCT)
- Prior art keywords
- ecm
- treatment
- cardiovascular disorders
- based compositions
- cardiovascular
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K38/1825—Fibroblast growth factor [FGF]
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- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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Abstract
Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US2013/028579 WO2014133541A2 (en) | 2013-03-01 | 2013-03-01 | Method and system for treatment of cardiovascular disorders |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US2013/028579 WO2014133541A2 (en) | 2013-03-01 | 2013-03-01 | Method and system for treatment of cardiovascular disorders |
Publications (2)
Publication Number | Publication Date |
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WO2014133541A2 WO2014133541A2 (en) | 2014-09-04 |
WO2014133541A3 true WO2014133541A3 (en) | 2015-06-18 |
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PCT/US2013/028579 WO2014133541A2 (en) | 2013-03-01 | 2013-03-01 | Method and system for treatment of cardiovascular disorders |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090138074A1 (en) * | 2003-07-17 | 2009-05-28 | Boston Scientific Scimed, Inc. | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
US20100145442A1 (en) * | 2006-11-03 | 2010-06-10 | Bull David A | Ventricular assist device capable of implantation of stem cells |
US20100233235A1 (en) * | 2009-02-18 | 2010-09-16 | Matheny Robert G | Compositions and methods for preventing cardiac arrhythmia |
US20130023721A1 (en) * | 2007-05-10 | 2013-01-24 | Matheny Robert G | Extracellular matrix encasement structures and methods |
-
2013
- 2013-03-01 WO PCT/US2013/028579 patent/WO2014133541A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090138074A1 (en) * | 2003-07-17 | 2009-05-28 | Boston Scientific Scimed, Inc. | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
US20100145442A1 (en) * | 2006-11-03 | 2010-06-10 | Bull David A | Ventricular assist device capable of implantation of stem cells |
US20130023721A1 (en) * | 2007-05-10 | 2013-01-24 | Matheny Robert G | Extracellular matrix encasement structures and methods |
US20100233235A1 (en) * | 2009-02-18 | 2010-09-16 | Matheny Robert G | Compositions and methods for preventing cardiac arrhythmia |
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WO2014133541A2 (en) | 2014-09-04 |
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