WO2014129975A1 - Identification de signatures de microarn en circulation pour la détection du cancer du sein - Google Patents

Identification de signatures de microarn en circulation pour la détection du cancer du sein Download PDF

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Publication number
WO2014129975A1
WO2014129975A1 PCT/SG2014/000073 SG2014000073W WO2014129975A1 WO 2014129975 A1 WO2014129975 A1 WO 2014129975A1 SG 2014000073 W SG2014000073 W SG 2014000073W WO 2014129975 A1 WO2014129975 A1 WO 2014129975A1
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WIPO (PCT)
Prior art keywords
mir
micrornas
microrna
breast cancer
subject
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PCT/SG2014/000073
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English (en)
Inventor
Kok Leong Maurice CHAN
Siew Gek Ann LEE-LIM
Original Assignee
Singapore Health Services Pte Ltd
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Publication date
Application filed by Singapore Health Services Pte Ltd filed Critical Singapore Health Services Pte Ltd
Publication of WO2014129975A1 publication Critical patent/WO2014129975A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

La présente invention concerne une méthode de détection du cancer du sein chez un sujet. Plus particulièrement, l'invention concerne une méthode de détection de la présence de microARN exprimés différentiellement dans le sang ou un tissu d'un sujet, lesquels sont caractéristiques de la présence d'un cancer du sein chez le sujet. La présente invention concerne également une méthode de détection si un sujet atteint d'un cancer du sein présente des caractéristiques clinico-pathologiques de positivité ER, positivité Her2 et/ou positivité des ganglions. La présente invention comprend également des trousses destinées à être utilisées dans les méthodes de l'invention.
PCT/SG2014/000073 2013-02-20 2014-02-20 Identification de signatures de microarn en circulation pour la détection du cancer du sein WO2014129975A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767054P 2013-02-20 2013-02-20
US61/767,054 2013-02-20

Publications (1)

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WO2014129975A1 true WO2014129975A1 (fr) 2014-08-28

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PCT/SG2014/000073 WO2014129975A1 (fr) 2013-02-20 2014-02-20 Identification de signatures de microarn en circulation pour la détection du cancer du sein

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144265A1 (fr) * 2015-03-09 2016-09-15 Agency For Science, Technology And Research Procédé de détermination du risque de développer un cancer du sein par détection des niveaux d'expression de micro-arn (miarn)
WO2016150475A1 (fr) * 2015-03-22 2016-09-29 Universite De Liege Micro-arn circulants pour diagnostiquer le cancer du sein
WO2017031086A1 (fr) * 2015-08-14 2017-02-23 Northwestern University Identification par la plateforme scano-mir d'une signature de microarn circulant distincte pour le diagnostic d'une maladie
WO2019117257A1 (fr) * 2017-12-13 2019-06-20 国立大学法人広島大学 Procédé d'aide à la détection du cancer du sein
WO2023014297A3 (fr) * 2021-08-02 2023-04-20 National University Of Singapore Panel de micro-arn circulants pour la détection précoce du cancer du sein et procédés associés

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012111588A1 (fr) * 2011-02-14 2012-08-23 株式会社ティーイーアイ Unité formant haut-parleur de type plat

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012111588A1 (fr) * 2011-02-14 2012-08-23 株式会社ティーイーアイ Unité formant haut-parleur de type plat

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHAN, M. ET AL.: "Identification of circulating microRNA signatures for breast cancer detection", CLINICAL CANCER RESEARCH, vol. 19, 2013, pages 4477 - 4487 ; *
GEO ACCESSION GPL14613: "Affymetrix MultiSpecies miRNA-2_0 Array", 7 October 2011 (2011-10-07), Retrieved from the Internet <URL:http://www.ncbi,;m.nlm.gov/geo/query/ace.egi?acc=gpl14613> [retrieved on 20140507] *
IORIO, M.V. ET AL.: "MicroRNA gene expression deregulation in human breast cancer", CANCER RESEARCH, vol. 65, no. 16, 2005, pages 7065 - 7070 *
NAVON, R. ET AL.: "Novel rank-based statistical methods reveal MicroRNAs with differential expression in multiple cancer types", PLOS ONE, vol. 4, no. 11, 2009, pages E8003 *
SI , H. ET AL.: "Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol. 139, no. 2, 2013, pages 223 - 229 ; *
WU, X. ET AL.: "De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 10, 2012, pages 42 *
ZHAO, H. ET AL.: "A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer", PLOS ONE, vol. 5, no. 10, 2010, pages E13735 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144265A1 (fr) * 2015-03-09 2016-09-15 Agency For Science, Technology And Research Procédé de détermination du risque de développer un cancer du sein par détection des niveaux d'expression de micro-arn (miarn)
WO2016150475A1 (fr) * 2015-03-22 2016-09-29 Universite De Liege Micro-arn circulants pour diagnostiquer le cancer du sein
WO2017031086A1 (fr) * 2015-08-14 2017-02-23 Northwestern University Identification par la plateforme scano-mir d'une signature de microarn circulant distincte pour le diagnostic d'une maladie
WO2019117257A1 (fr) * 2017-12-13 2019-06-20 国立大学法人広島大学 Procédé d'aide à la détection du cancer du sein
JPWO2019117257A1 (ja) * 2017-12-13 2020-12-24 国立大学法人広島大学 乳がんの検出を補助する方法
JP7298913B2 (ja) 2017-12-13 2023-06-27 国立大学法人広島大学 乳がんの検出を補助する方法
WO2023014297A3 (fr) * 2021-08-02 2023-04-20 National University Of Singapore Panel de micro-arn circulants pour la détection précoce du cancer du sein et procédés associés

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