WO2014124174A3 - Circulating bmec and related cells as biomarkers of cns diseases associated with the blood-brain-barrier disorders - Google Patents

Circulating bmec and related cells as biomarkers of cns diseases associated with the blood-brain-barrier disorders Download PDF

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Publication number
WO2014124174A3
WO2014124174A3 PCT/US2014/015158 US2014015158W WO2014124174A3 WO 2014124174 A3 WO2014124174 A3 WO 2014124174A3 US 2014015158 W US2014015158 W US 2014015158W WO 2014124174 A3 WO2014124174 A3 WO 2014124174A3
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WO
WIPO (PCT)
Prior art keywords
blood
brain
bmec
biomarkers
circulating
Prior art date
Application number
PCT/US2014/015158
Other languages
French (fr)
Other versions
WO2014124174A2 (en
Inventor
Sheng-he HUANG
Ambrose JONG
Feng Chi
Lin Wang
Original Assignee
Children's Hospital Los Angeles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children's Hospital Los Angeles filed Critical Children's Hospital Los Angeles
Publication of WO2014124174A2 publication Critical patent/WO2014124174A2/en
Publication of WO2014124174A3 publication Critical patent/WO2014124174A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Abstract

Described herein are processes, assays and methods for detecting damage to the blood-brain barrier by assaying the levels of any one or more of cBMEC, EPC and/or UCHL1. An increase in the levels of cBMEC, EPC and/or UCHL1 in a sample obtained from the subject is indicative of damage to the blood-brain barrier.
PCT/US2014/015158 2013-02-08 2014-02-06 Circulating bmec and related cells as biomarkers of cns diseases associated with the blood-brain-barrier disorders WO2014124174A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361762794P 2013-02-08 2013-02-08
US61/762,794 2013-02-08

Publications (2)

Publication Number Publication Date
WO2014124174A2 WO2014124174A2 (en) 2014-08-14
WO2014124174A3 true WO2014124174A3 (en) 2014-10-23

Family

ID=51300263

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/015158 WO2014124174A2 (en) 2013-02-08 2014-02-06 Circulating bmec and related cells as biomarkers of cns diseases associated with the blood-brain-barrier disorders

Country Status (1)

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WO (1) WO2014124174A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190336541A1 (en) * 2017-01-11 2019-11-07 Sungkwang Medical Foundation Pcnt as a target protein for treatment or diagnosis of brain-nervous system diseases
US10345302B2 (en) * 2017-02-19 2019-07-09 Sheng-He Huang Circulating astrocytes and MFSD2A as biomarkers
CN110494752A (en) * 2017-03-23 2019-11-22 雅培实验室 With the method for early stage biomarker ubiquitin carboxy terminal hydrolase-l 1 assisted diagnosis measurement people experimenter traumatic brain injury degree
AU2018275235A1 (en) 2017-05-30 2019-10-31 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I and early biomarkers
US20210172950A1 (en) * 2018-06-29 2021-06-10 The General Hospital Corporation Isolating and analyzing rare brain-derived cells and particles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086915A1 (en) * 2002-08-28 2004-05-06 Board Of Regents, The University Of Texas System Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample
US20120172254A1 (en) * 2009-06-12 2012-07-05 Vaccine Technologies, Incorporated Methods and compositions for diagnostic assays for measuring cell mediated immune response

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086915A1 (en) * 2002-08-28 2004-05-06 Board Of Regents, The University Of Texas System Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample
US20120172254A1 (en) * 2009-06-12 2012-07-05 Vaccine Technologies, Incorporated Methods and compositions for diagnostic assays for measuring cell mediated immune response

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHI ET AL.: "Meningitic Escherichia coli K1 Penetration and Neutrophil Transmigration Across the Blood's Brain Barrier are Modulated by Alpha7 Nicotinic Receptor", PLOS ONE, vol. 6, no. 9, 2011, pages 2 *
NADAR ET AL.: "Circulating endothelial cells in acute ischaemic stroke", THROMB HAEMOST, vol. 94, 2005, pages 707 - 712 *
POURCYROUS ET AL.: "613.6. Detection of brain-derived circulating endothelial cells in peripheral blood of newborn infants with cerebrovascular disorders.", FASEB J., April 2009 (2009-04-01) *
WOYWODT ET AL.: "An improved assay for enumeration of circulating endothelial cells", ANN HEMATOL, vol. 83, 2004, pages 491 - 494 *

Also Published As

Publication number Publication date
WO2014124174A2 (en) 2014-08-14

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