WO2014123280A1 - Dispositif de stérilisation à plasma micro-ondes - Google Patents

Dispositif de stérilisation à plasma micro-ondes Download PDF

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Publication number
WO2014123280A1
WO2014123280A1 PCT/KR2013/004709 KR2013004709W WO2014123280A1 WO 2014123280 A1 WO2014123280 A1 WO 2014123280A1 KR 2013004709 W KR2013004709 W KR 2013004709W WO 2014123280 A1 WO2014123280 A1 WO 2014123280A1
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WO
WIPO (PCT)
Prior art keywords
plasma
reaction chamber
microwave
hydrogen peroxide
generating unit
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Application number
PCT/KR2013/004709
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English (en)
Korean (ko)
Inventor
노태협
석동찬
Original Assignee
한국 기초 과학 지원연구원
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Publication of WO2014123280A1 publication Critical patent/WO2014123280A1/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14Plasma, i.e. ionised gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20Gaseous substances, e.g. vapours
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20Gaseous substances, e.g. vapours
    • A61L2/208Hydrogen peroxide

Definitions

  • the present invention relates to a plasma sterilization apparatus, and more particularly, to a device for adding a hydrogen peroxide to generate a plasma and to generate OH radicals effective for sterilization to achieve the sterilization of the workpiece.
  • Sterilization of medical devices includes the use of ethylene oxide (ETO) gas, the use of ozone and water, and the use of high temperature steam.
  • ETO ethylene oxide
  • the ETO contact method has excellent sterilization effect, but the ETO gas is toxic, so it may cause serious harm to the user's health and is difficult to handle. And the use of ozone and water requires very long treatment times. In addition, the sterilization method using high temperature steam has a short sterilization time and excellent sterilization effect.
  • the present invention is to solve the problems described above, to provide a plasma sterilization apparatus that can be used for the low-cost and heat-sensitive material to be processed and can shorten the sterilization treatment time.
  • Plasma sterilization apparatus the reaction chamber; A vacuum forming unit connected to the reaction chamber and configured to vacuum the inside of the reaction chamber; A hydrogen peroxide supply unit providing gaseous hydrogen peroxide to the reaction chamber; It includes; and a microwave plasma generating unit for generating a plasma by using a microwave.
  • the vacuum forming unit may be to evacuate the reaction chamber through the plasma generating unit, but is not limited thereto.
  • the microwave plasma generating unit the electromagnetic wave generating source; A plasma generator; And a microwave guide configured to transfer the microwave generated from the electromagnetic wave generating source to the plasma generator.
  • the present invention is not limited thereto.
  • the plasma generating unit may be a dielectric material, but is not limited thereto.
  • the plasma generating unit may be a tube or cup shape, but is not limited thereto.
  • the plasma generating unit is made of a double tube, the cooling fluid may flow between the two tubes, but is not limited thereto.
  • the microwave guide is in the form of a tube closed at both ends, the electromagnetic wave source and the plasma generating unit may be spaced apart along the longitudinal direction, but is not limited thereto.
  • the microwave plasma generating unit may be separated from the reaction chamber, but is not limited thereto.
  • the to-be-processed object may be sterilized by a radical element formed by being decomposed in the reaction chamber by the plasma generated from the hydrogen peroxide supply unit, the microwave plasma generating unit, It is not limited to this.
  • the radical element may be one containing an OH radical element, a HO 2 radical element or both, but is not limited thereto.
  • the present invention provides a sterilization apparatus that can be reused after use of a workpiece, provides a sterilization apparatus that can be used to sterilize a workpiece that is susceptible to heat deformation, and provides a relatively low-cost hydrogen peroxide plasma sterilization apparatus, and short sterilization. It provides a sterilization device having a time, provides a sterilization device of a simple structure, a simple procedure of use, and provides a sterilization device capable of sterilization even at an ambient temperature of less than 30 °C.
  • a microwave generator MicroWave
  • the plasma is mainly generated in the region other than the periphery of the workpiece to allow the generated radical elements to contact the workpiece.
  • Figure 1 is a schematic diagram showing a plasma sterilization apparatus according to an embodiment of the present invention.
  • FIG. 2 is a configuration diagram schematically showing a hydrogen peroxide supply unit.
  • FIG. 3 is a perspective view of a microwave plasma generating unit.
  • FIG. 4 is a plan view of the microwave plasma generation unit of FIG.
  • FIG. 5 is a configuration diagram schematically showing a state in which the microwave plasma generation unit of FIG. 3 is connected to the reaction chamber.
  • Figure 6 is a flow chart illustrating a sterilization method of the medical equipment to be processed by the plasma sterilization apparatus of the present invention.
  • the plasma sterilization apparatus according to the present invention has the following features.
  • a microwave can be trapped in a cavity such as a waveguide, and a standing wave can be constructed to obtain a high electric field, which can generate a plasma in a specific gas.
  • Microwave plasmas have the advantage of being able to obtain higher electron temperatures and plasma densities than conventional DC or RF plasmas and to maintain the plasma in a wider range of pressure conditions. (eg 5 to 15 eV, 108 to 1015 cm -3 , unmagnetized: 10 mtorr to 760 torr, magnetized: several ⁇ torr to 10 mtorr) Also, relatively high ionization rates can be achieved, and the sheath voltage is low, resulting in sputtering ) Has the advantage of minimizing the damage to the electrode or structure.
  • an appropriate wave guide to an electromagnetic wave source (magnetron, etc.) that can generate microwaves, and by installing a dielectric load at one end, a plasma can be generated by forming an appropriate pd (pressure ⁇ gap) inside the dielectric load.
  • pd pressure ⁇ gap
  • Plasma can be generated at low temperature, so it is possible to sterilize heat-sensitive materials such as resin, and can be applied to medical devices with fine and complicated structure by adjusting pressure.
  • the plasma generating unit is spaced apart from the object to be processed, failure of the object to be processed by an electric shock, for example, a medical device can be prevented.
  • the plasma sterilization apparatus 100 includes a reaction chamber 110, a vacuum forming unit 120, an outside air supply unit 130, a hydrogen peroxide supply unit 140, and a microwave plasma generating unit 150. It includes.
  • the reaction chamber 110 is a reactor to be sterilized with, for example, medical equipment or cooking utensils.
  • the reaction chamber 110 includes a temperature measuring sensor 111 for measuring a temperature in the reaction chamber 110, a pressure measuring sensor 112 for measuring a pressure in the reaction chamber 110, a reaction chamber 110, and an object to be processed.
  • a heater (not shown) for controlling the temperature of the water is provided.
  • the reaction chamber 110 is provided with an openable work door, a vacuum exhaust port, an ozone supply port, a hydrogen peroxide supply port, and an external air supply port.
  • the interior of the reaction chamber 110 can guarantee a vacuum degree of less than about 100 mtorr, and the internal volume is calculated according to the needs of the intended use.
  • the vacuum forming unit 120 is connected to the reaction chamber 110, and includes a vacuum pump 121, a first connection pipe 122, and a first control valve 122.
  • the vacuum forming unit 120 makes the inside of the reaction chamber 110 in a vacuum state through the microwave plasma generating unit 150.
  • the vacuum pump 121 exhausts the gas inside the reaction chamber 110 to the outside.
  • the vacuum pump 121 preferably has durability against hydrogen peroxide.
  • the first connection pipe 122 connects between the vacuum pump 121 and the vacuum exhaust pipe (not shown) provided in the reaction chamber 110.
  • the first control valve 123 is installed on the first connection pipe 122 to open and close the first connection pipe 122.
  • the exhaust gas passing through the vacuum pump 121 passes through the oxidant removal device 124 and is finally exhausted.
  • the outside air supply unit 130 includes a second control valve 131, a second connection pipe 132, and a heater 133.
  • the outside air supply unit 130 supplies outside air to the reaction chamber 110 when necessary.
  • the second control valve 131 is installed on the second connection pipe 132 to open and close the second connection pipe 132.
  • the second connection pipe 132 is connected to an external air supply port (not shown) provided in the reaction chamber 110.
  • the heater 133 is installed adjacent to an external air supply port (not shown) on the second connection pipe 132 to control the temperature of the reaction chamber 110.
  • the hydrogen peroxide supply unit 140 includes a hydrogen peroxide vaporizer 141, a third connecting pipe 142, and a third control valve 143.
  • the hydrogen peroxide supply unit 140 supplies the vaporized hydrogen peroxide into the reaction chamber 110.
  • the hydrogen peroxide vaporizer 141 provides a storage space in which hydrogen peroxide is stored, and includes a heater 141a, a temperature controller 141b, a drain valve 141c, a water supply valve 141d, and a water level sensor 141e. It is provided.
  • the heater 141a prevents the liquid hydrogen peroxide from being cooled and frozen by excessive evaporation.
  • the temperature controller 141b controls the operation of the heater 141a.
  • the drain valve 141c is used to drain the liquid hydrogen peroxide stored in the hydrogen peroxide vaporizer 141.
  • the water supply valve 141d is used to supply liquid hydrogen peroxide in the hydrogen peroxide vaporizer 141.
  • the amount of liquid hydrogen peroxide stored in the hydrogen peroxide vaporizer 141 is measured through the water level sensor 141e.
  • the concentration of hydrogen peroxide used in the hydrogen peroxide vaporizer 141 is 1 to 100%.
  • hydrogen peroxide may be provided to the reaction chamber 110 by a method such as spraying or ozone acid.
  • the hydrogen peroxide vaporization apparatus 141 has a concentration of 3 to 100% so that the hydrogen peroxide supply amount is evaporated and supplied by an amount corresponding to less than 100% of the saturation pressure of the internal volume of the reaction chamber 110 at the set temperature of the reaction chamber 110. Liquid hydrogen peroxide can be evaporated.
  • the third connection pipe 142 connects between the hydrogen peroxide vaporizer 141 and the microwave plasma generator 150. It is preferable that the 3rd connection pipe 142 becomes temperature control or heat insulation.
  • the third control valve 143 is installed on the third connection pipe 142 to open and close the third connection pipe 142.
  • FIG. 3 is a perspective view of the microwave plasma generating unit
  • FIG. 4 is a plan view of the microwave plasma generating unit
  • FIG. 5 is a configuration diagram schematically showing a state in which the microwave plasma generating unit of FIG. 3 is connected to the reaction chamber.
  • the microwave plasma generating unit 150 is separated from the reaction chamber 110, the microwave generating source 153, the plasma generating unit 151, the microwave generated from the electromagnetic wave generating source. It is provided with a microwave guide 152 and the power supply 159 for transmitting to the plasma generating unit.
  • the electromagnetic wave generator 153 generates a microwave.
  • Microwave is a frequency of 0.3 to 300 kHz, which is used in military radar, home cooker, wireless communication, etc., and has the same band as rotational frequency of water atom to absorb water and heat water molecules. Have In addition, the possibility of long distance power transmission has been reported.
  • the magnetron is used as the electromagnetic wave generator 153, but the present invention is not limited thereto.
  • the electromagnetic wave generation source 153 includes an antenna 153a.
  • the electromagnetic wave generator 153 operates by receiving power from the power supply 159.
  • the microwave guide 152 is in the form of a tube of square cross-section with both ends closed.
  • the microwave source 153 and the microwave plasma generator 154 are spaced apart from each other in the microwave guide 152 along the longitudinal direction.
  • the antenna 153a of the electromagnetic wave generator 153 is located in the inner space of the microwave guide 152.
  • the microwave guide 152 transmits the microwaves generated from the electromagnetic wave generator 153 to the plasma generator 154.
  • the microwave guide 152 has an electromagnetic wave source installation hole 152a formed corresponding to the position where the electromagnetic wave source 153 is installed, and a plasma generation unit installation hole 152b formed corresponding to the position where the plasma generator 154 is installed. ) Is provided.
  • a plurality of tuner mounting holes 152c are provided between the electromagnetic wave source mounting hole 152a and the plasma generating unit mounting hole 152b, which are sequentially located along the longitudinal direction of the microwave guide 152.
  • the plasma generating unit 154 may be made of a dielectric material and is installed in the plasma generating unit installation hole 152b to pass through the inner space of the microwave guide 152 as a tube or cup shape.
  • One end of the plasma generating unit 154 is connected to the reaction chamber 110 and the other end is connected to the third connection pipe 142 of the hydrogen peroxide supply unit 140 so that the hydrogen peroxide gas passes through the plasma generating unit 154 and the reaction chamber 110. Is provided.
  • the plasma is generated by the microwave of the plasma generating unit 154, and the object to be processed is formed by decomposing the hydrogen peroxide supplied from the hydrogen peroxide supply unit 140 in the reaction chamber by the plasma supplied from the microwave plasma generating unit. Sterilized by a radical element.
  • the radical element may be one containing OH radicals, HO 2 radicals, or both, and high oxidizing chemicals are produced to accelerate the sterilization reaction.
  • the plasma generator 154 may be configured as a double tube to allow a cooling fluid (oil, compressed air, etc.) to flow between the tube and the tube.
  • the tuner unit 155 includes a plurality of tuning members 155a.
  • the tuning member 155a is coupled to the tuner installation hole 152c formed in the microwave guide 152 in a rod-like manner in the same manner as the screwing.
  • Tuning member 155a is adjusted in length protruding into the inner space of the microwave guide 152, respectively. In the present embodiment, it will be described that three tuning members 155a are provided.
  • the air outside the reaction chamber 110 may be opened by opening the first control valve 131. Condition by purging. In this case, the heated air may be supplied using the heater 133.
  • the sterilization method of the object for example medical equipment by the plasma sterilization apparatus of the present invention.
  • the to-be-processed object of the present invention is not limited to medical equipment, and various devices requiring sterilization or sterilization such as cooking utensils may be applied.
  • FIG. 6 is a flowchart illustrating a sterilization method of a target object by the plasma sterilization apparatus of the present invention.
  • the sterilization method of the workpiece the workpiece loading step (S10), temperature control step (S20), vacuum exhaust step (S30), plasma generation step (S40), hydrogen peroxide injection step (S50), sterilization step (S60), the ventilation step (S70), the vacuum release step (S80), and the workpiece recovery step (S90).
  • the medical equipment which is the processing object, is loaded in the reaction chamber (110 of FIG. 1) while the plasma sterilization apparatus shown in FIG. 1 does not operate.
  • the temperature of the reaction chamber is properly maintained so that vaporized hydrogen peroxide supplied from the hydrogen peroxide supply unit (140 in FIG. 1) does not condense in the reaction chamber (110 in FIG. 1).
  • the inside of the reaction chamber (110 of FIG. 1) is evacuated to 10 torr or less by using the vacuum forming unit 120 so that the sterilant can be evenly penetrated to the inside of the microstructure of the workpiece. .
  • the microwave plasma generation unit (150 in FIG. 1) is operated to generate plasma in the plasma generation unit (154 in FIG. 3).
  • Plasma generation can then continue within a time range of up to 60 minutes after hydrogen peroxide injection. Plasma generation is terminated before venting to the reaction chamber, or after continuing to the venting procedure for the reaction chamber if the vacuum evacuation proceeds through the plasma generator.
  • hydrogen peroxide injection step (S50) hydrogen peroxide vaporized by the hydrogen peroxide supply unit (FIG. 140) is injected into the reaction chamber (110 in FIG. 1) through the plasma generation unit (154 in FIG. 3).
  • vacuum evacuation to less than 10torr for the reaction chamber (110 in FIG. 1) is performed.
  • the vacuum exhaust may proceed to pass through the plasma generating unit 154 of FIG. 3, in which case the unreacted hydrogen peroxide may be changed into water and oxygen to prevent the residual hydrogen peroxide from being discharged to the outside.
  • the vacuum state formed inside the reaction chamber (110 of FIG. 1) is released through the ventilation step S70.
  • the sterilized treatment object is recovered.
  • the plasma generating step S40 to the ventilation step S70 may be repeated two or more times.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

La présente invention concerne un dispositif de stérilisation à plasma. Le dispositif de stérilisation à plasma, selon la présente invention, comprend : une chambre de réaction ; une unité de formation de vide qui est raccordée à la chambre de réaction et forme un état de vide à l'intérieur de la chambre de réaction ; une unité d'alimentation de peroxyde d'hydrogène pour alimenter du peroxyde d'hydrogène dans un état gazeux à l'intérieur de la chambre de réaction ; et une unité de génération de plasma micro-ondes pour générer un plasma en utilisant des micro-ondes.
PCT/KR2013/004709 2013-02-07 2013-05-29 Dispositif de stérilisation à plasma micro-ondes WO2014123280A1 (fr)

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KR1020130013749A KR20140100699A (ko) 2013-02-07 2013-02-07 마이크로웨이브 플라즈마 멸균 장치
KR10-2013-0013749 2013-02-07

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017218832A1 (fr) * 2016-06-17 2017-12-21 Sterifre Medical Inc. Dispositifs thérapeutiques, systèmes et procédés pour la stérilisation, la désinfection, le nettoyage et la décontamination
USRE47582E1 (en) 2009-07-28 2019-08-27 Sterifre Medical, Inc. Free radical sterilization system and method
US11344643B2 (en) 2017-10-25 2022-05-31 Sterifre Medical, Inc. Devices, systems, and methods for sterilization, disinfection, sanitization and decontamination

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102630045B1 (ko) * 2021-07-10 2024-01-25 오영래 알에프 전자기파 에너지를 이용한 플라즈마 연속 공급형 공기살균장치

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KR100458112B1 (ko) * 2003-12-26 2004-11-20 (주)케이.씨.텍 과산화수소 플라즈마 멸균 시스템
JP2005279042A (ja) * 2004-03-30 2005-10-13 Yasuo Suzuki 滅菌方法及び滅菌装置
KR20080081102A (ko) * 2004-11-26 2008-09-05 주식회사 휴먼메디텍 과산화수소 증기 멸균 장치 및 이를 이용한 멸균 방법
US20100028200A1 (en) * 2004-01-16 2010-02-04 CISA s.r.l Vacuum sterilization process and devices
KR20120135129A (ko) * 2011-06-03 2012-12-12 한국기초과학지원연구원 마이크로웨이브를 이용한 의료용 멸균장치
KR20120135128A (ko) * 2011-06-03 2012-12-12 한국기초과학지원연구원 의료용 플라즈마 멸균장치

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Publication number Priority date Publication date Assignee Title
KR100458112B1 (ko) * 2003-12-26 2004-11-20 (주)케이.씨.텍 과산화수소 플라즈마 멸균 시스템
US20100028200A1 (en) * 2004-01-16 2010-02-04 CISA s.r.l Vacuum sterilization process and devices
JP2005279042A (ja) * 2004-03-30 2005-10-13 Yasuo Suzuki 滅菌方法及び滅菌装置
KR20080081102A (ko) * 2004-11-26 2008-09-05 주식회사 휴먼메디텍 과산화수소 증기 멸균 장치 및 이를 이용한 멸균 방법
KR20120135129A (ko) * 2011-06-03 2012-12-12 한국기초과학지원연구원 마이크로웨이브를 이용한 의료용 멸균장치
KR20120135128A (ko) * 2011-06-03 2012-12-12 한국기초과학지원연구원 의료용 플라즈마 멸균장치

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47582E1 (en) 2009-07-28 2019-08-27 Sterifre Medical, Inc. Free radical sterilization system and method
USRE49474E1 (en) 2009-07-28 2023-03-28 Sterifre Medical, Inc. Free radical sterilization system and method
WO2017218832A1 (fr) * 2016-06-17 2017-12-21 Sterifre Medical Inc. Dispositifs thérapeutiques, systèmes et procédés pour la stérilisation, la désinfection, le nettoyage et la décontamination
US11253620B2 (en) 2016-06-17 2022-02-22 Sterifre Medical, Inc. Sterilization, disinfection, sanitization, decontamination, and therapeutic devices, systems, and methods
US11344643B2 (en) 2017-10-25 2022-05-31 Sterifre Medical, Inc. Devices, systems, and methods for sterilization, disinfection, sanitization and decontamination

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