WO2014112956A1 - Méthode de traitement d'un greffon vasculaire - Google Patents
Méthode de traitement d'un greffon vasculaire Download PDFInfo
- Publication number
- WO2014112956A1 WO2014112956A1 PCT/SI2013/000003 SI2013000003W WO2014112956A1 WO 2014112956 A1 WO2014112956 A1 WO 2014112956A1 SI 2013000003 W SI2013000003 W SI 2013000003W WO 2014112956 A1 WO2014112956 A1 WO 2014112956A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- molecules
- electronically excited
- treatment
- vascular graft
- vascular
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Definitions
- Figure 6 shows the adsorbed mass of fibrinogen on untreated PET surface and on PET surface treated by the method of the invention
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
L'invention concerne une méthode de traitement d'un greffon vasculaire qui répond au besoin pour des méthodes améliorées permettant d'augmenter l'hémocompatibilité de greffons vasculaires en polymères de téréphtalate de polyéthylène par comparaison à l'état de la technique. La présente invention n'implique pas de dépôt ou de greffe d'un quelconque revêtement antithrombogène sur les parois internes de greffons vasculaires. L'invention concerne une méthode qui permet d'améliorer l'hémocompatibilité de greffons vasculaires par traitement des parois internes par des molécules d'oxygène excitées. L'efficacité de la méthode qui fait l'objet de l'invention est confirmée par le comportement de plaquettes sanguines sur des greffons vasculaires modifiés. Par comparaison à l'état de la technique, les méthodes de la présente invention empêchent les plaquettes de se transformer, d'un état normal dans du sang sain, à des états hautement activés, ce qui pourrait provoquer des réactions entraînant la formation de caillots sanguins non désirés. Ainsi, la présente invention permet d'améliorer l'hémocompatibilité des surfaces artificielles de téréphtalate de polyéthylène, et de réduire fortement la transformation de la forme des plaquettes de leur forme ronde ou discoïde à l'état normal à leur forme dendritique à dendritique étalée, et étalée à complètement étalée.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SI2013/000003 WO2014112956A1 (fr) | 2013-01-17 | 2013-01-17 | Méthode de traitement d'un greffon vasculaire |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SI2013/000003 WO2014112956A1 (fr) | 2013-01-17 | 2013-01-17 | Méthode de traitement d'un greffon vasculaire |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014112956A1 true WO2014112956A1 (fr) | 2014-07-24 |
Family
ID=47989347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SI2013/000003 WO2014112956A1 (fr) | 2013-01-17 | 2013-01-17 | Méthode de traitement d'un greffon vasculaire |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014112956A1 (fr) |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
US4521564A (en) | 1984-02-10 | 1985-06-04 | Warner-Lambert Company | Covalent bonded antithrombogenic polyurethane material |
US4613517A (en) | 1983-04-27 | 1986-09-23 | Becton, Dickinson And Company | Heparinization of plasma treated surfaces |
US4987181A (en) | 1985-07-08 | 1991-01-22 | Battelle Memorial Institute | Substrate with an antithromogenic active surface |
WO1996008149A1 (fr) | 1994-09-16 | 1996-03-21 | Beatrice Haimovich | Traitement de surface thromboresistant pour biomateriaux |
DE19724869A1 (de) | 1997-06-12 | 1998-12-24 | Henkel Kgaa | Verwendung von Chitosan und/oder Citosanderivaten zur Oberflächenbeschichtung |
US6033582A (en) | 1996-01-22 | 2000-03-07 | Etex Corporation | Surface modification of medical implants |
FR2793693A3 (fr) | 1999-05-18 | 2000-11-24 | Martine Bulette | Prothese vasculaire impregnee par un biopolymere d'origine vegetale ou bacterienne et procede pour la realisation d'une telle prothese |
US20040234575A1 (en) | 2002-05-09 | 2004-11-25 | Roland Horres | Medical products comprising a haemocompatible coating, production and use thereof |
WO2005053765A1 (fr) | 2003-11-27 | 2005-06-16 | Floreane Medical Implants | Composition de revetement a base de collagene et de polysaccharides |
US20060228391A1 (en) | 2004-07-12 | 2006-10-12 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
US7803393B2 (en) | 2002-03-08 | 2010-09-28 | Board Of Regents, The University Of Texas System | Preparing an implant by gas-plasma treatment of a substrate to couple cells |
WO2010123465A2 (fr) * | 2009-04-20 | 2010-10-28 | Institut "Jožef Stefan" | Procédé pour le traitement d'implants polymères biomédicaux pour l'amélioration de leurs propriétés antithrombogènes |
-
2013
- 2013-01-17 WO PCT/SI2013/000003 patent/WO2014112956A1/fr active Application Filing
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
US4613517A (en) | 1983-04-27 | 1986-09-23 | Becton, Dickinson And Company | Heparinization of plasma treated surfaces |
US4521564A (en) | 1984-02-10 | 1985-06-04 | Warner-Lambert Company | Covalent bonded antithrombogenic polyurethane material |
US4987181A (en) | 1985-07-08 | 1991-01-22 | Battelle Memorial Institute | Substrate with an antithromogenic active surface |
WO1996008149A1 (fr) | 1994-09-16 | 1996-03-21 | Beatrice Haimovich | Traitement de surface thromboresistant pour biomateriaux |
US6033582A (en) | 1996-01-22 | 2000-03-07 | Etex Corporation | Surface modification of medical implants |
DE19724869A1 (de) | 1997-06-12 | 1998-12-24 | Henkel Kgaa | Verwendung von Chitosan und/oder Citosanderivaten zur Oberflächenbeschichtung |
FR2793693A3 (fr) | 1999-05-18 | 2000-11-24 | Martine Bulette | Prothese vasculaire impregnee par un biopolymere d'origine vegetale ou bacterienne et procede pour la realisation d'une telle prothese |
US7803393B2 (en) | 2002-03-08 | 2010-09-28 | Board Of Regents, The University Of Texas System | Preparing an implant by gas-plasma treatment of a substrate to couple cells |
US20040234575A1 (en) | 2002-05-09 | 2004-11-25 | Roland Horres | Medical products comprising a haemocompatible coating, production and use thereof |
EP1501565A1 (fr) | 2002-05-09 | 2005-02-02 | Hemoteq GmbH | Composes et procedes pour recouvrir de fa on hemocompatible des surfaces |
WO2005053765A1 (fr) | 2003-11-27 | 2005-06-16 | Floreane Medical Implants | Composition de revetement a base de collagene et de polysaccharides |
US20060228391A1 (en) | 2004-07-12 | 2006-10-12 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
WO2010123465A2 (fr) * | 2009-04-20 | 2010-10-28 | Institut "Jožef Stefan" | Procédé pour le traitement d'implants polymères biomédicaux pour l'amélioration de leurs propriétés antithrombogènes |
Non-Patent Citations (9)
Title |
---|
ALENKA VESEL ET AL: "Surface modification of polyester by oxygen- and nitrogen-plasma treatment", SURFACE AND INTERFACE ANALYSIS, vol. 40, no. 11, 10 October 2008 (2008-10-10), pages 1444 - 1453, XP055084372, ISSN: 0142-2421, DOI: 10.1002/sia.2923 * |
CHANDY, T.; DAS, G. S.; WILSON, R. F.; RAO, G. H. R., BIOMATERIALS, vol. 21, 2000, pages 699 |
GOODMAN ET AL.: "Platelet responses to silicon-alloyed pyrolytic carbons", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 83A, 2006, pages 64 |
KASEMO, B.: "Biological surface science", SURFACE SCIENCE, vol. 500, 2002, pages 656 |
SHI ET AL.: "Biomaterials and Tissue Engineering", 2004, SPRINGER-VERLAG |
TZONEVA-VELINOVA ET AL., JOURNAL OF MATERIAL SCIENCE, vol. 19, 2008, pages 3203 |
UROS CVELBAR ET AL: "Hemocompatible Poly(ethylene terephthalate) Polymer Modified via Reactive Plasma Treatment", JAPANESE JOURNAL OF APPLIED PHYSICS, vol. 50, no. 8, 1 August 2011 (2011-08-01), pages 08JF02, XP055084367, ISSN: 0021-4922, DOI: 10.1143/JJAP.50.08JF02 * |
VESEL A ET AL: "Surface functionalization of organic materials by weakly ionized highly dissociated oxygen plasma", JOURNAL OF PHYSICS: CONFERENCE SERIES, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 162, no. 1, 1 April 2009 (2009-04-01), pages 12015, XP020157453, ISSN: 1742-6596 * |
WISSINK, M.J.B.; BEERNINK, R.; POOT, A.A.; ENGBERS, G.H.M.; BEUGELING, T.; VAN AKEN, W.G.; FEIJEN, J.: "Improved endothelialization of vascular grafts by local release of growth factor from heparinized collagen matrices", JOURNAL OF CONTROLLED RELEASE, vol. 64, 2000, pages 103 |
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