WO2014112956A1 - Méthode de traitement d'un greffon vasculaire - Google Patents

Méthode de traitement d'un greffon vasculaire Download PDF

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Publication number
WO2014112956A1
WO2014112956A1 PCT/SI2013/000003 SI2013000003W WO2014112956A1 WO 2014112956 A1 WO2014112956 A1 WO 2014112956A1 SI 2013000003 W SI2013000003 W SI 2013000003W WO 2014112956 A1 WO2014112956 A1 WO 2014112956A1
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
electronically excited
treatment
vascular graft
vascular
Prior art date
Application number
PCT/SI2013/000003
Other languages
English (en)
Inventor
Ita Junkar
Martina MODIC
Alenka Vesel
Karin Stana KLEINSCHEK
Zdenka PERŠIN
Miran Mozetič
Aleš DOLIŠKA
Original Assignee
Center Odličnosti Polimerni Marteriali In Tehnologije
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Center Odličnosti Polimerni Marteriali In Tehnologije filed Critical Center Odličnosti Polimerni Marteriali In Tehnologije
Priority to PCT/SI2013/000003 priority Critical patent/WO2014112956A1/fr
Publication of WO2014112956A1 publication Critical patent/WO2014112956A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Definitions

  • Figure 6 shows the adsorbed mass of fibrinogen on untreated PET surface and on PET surface treated by the method of the invention

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une méthode de traitement d'un greffon vasculaire qui répond au besoin pour des méthodes améliorées permettant d'augmenter l'hémocompatibilité de greffons vasculaires en polymères de téréphtalate de polyéthylène par comparaison à l'état de la technique. La présente invention n'implique pas de dépôt ou de greffe d'un quelconque revêtement antithrombogène sur les parois internes de greffons vasculaires. L'invention concerne une méthode qui permet d'améliorer l'hémocompatibilité de greffons vasculaires par traitement des parois internes par des molécules d'oxygène excitées. L'efficacité de la méthode qui fait l'objet de l'invention est confirmée par le comportement de plaquettes sanguines sur des greffons vasculaires modifiés. Par comparaison à l'état de la technique, les méthodes de la présente invention empêchent les plaquettes de se transformer, d'un état normal dans du sang sain, à des états hautement activés, ce qui pourrait provoquer des réactions entraînant la formation de caillots sanguins non désirés. Ainsi, la présente invention permet d'améliorer l'hémocompatibilité des surfaces artificielles de téréphtalate de polyéthylène, et de réduire fortement la transformation de la forme des plaquettes de leur forme ronde ou discoïde à l'état normal à leur forme dendritique à dendritique étalée, et étalée à complètement étalée.
PCT/SI2013/000003 2013-01-17 2013-01-17 Méthode de traitement d'un greffon vasculaire WO2014112956A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/SI2013/000003 WO2014112956A1 (fr) 2013-01-17 2013-01-17 Méthode de traitement d'un greffon vasculaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SI2013/000003 WO2014112956A1 (fr) 2013-01-17 2013-01-17 Méthode de traitement d'un greffon vasculaire

Publications (1)

Publication Number Publication Date
WO2014112956A1 true WO2014112956A1 (fr) 2014-07-24

Family

ID=47989347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2013/000003 WO2014112956A1 (fr) 2013-01-17 2013-01-17 Méthode de traitement d'un greffon vasculaire

Country Status (1)

Country Link
WO (1) WO2014112956A1 (fr)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4326532A (en) 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4521564A (en) 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
US4613517A (en) 1983-04-27 1986-09-23 Becton, Dickinson And Company Heparinization of plasma treated surfaces
US4987181A (en) 1985-07-08 1991-01-22 Battelle Memorial Institute Substrate with an antithromogenic active surface
WO1996008149A1 (fr) 1994-09-16 1996-03-21 Beatrice Haimovich Traitement de surface thromboresistant pour biomateriaux
DE19724869A1 (de) 1997-06-12 1998-12-24 Henkel Kgaa Verwendung von Chitosan und/oder Citosanderivaten zur Oberflächenbeschichtung
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
FR2793693A3 (fr) 1999-05-18 2000-11-24 Martine Bulette Prothese vasculaire impregnee par un biopolymere d'origine vegetale ou bacterienne et procede pour la realisation d'une telle prothese
US20040234575A1 (en) 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
WO2005053765A1 (fr) 2003-11-27 2005-06-16 Floreane Medical Implants Composition de revetement a base de collagene et de polysaccharides
US20060228391A1 (en) 2004-07-12 2006-10-12 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US7803393B2 (en) 2002-03-08 2010-09-28 Board Of Regents, The University Of Texas System Preparing an implant by gas-plasma treatment of a substrate to couple cells
WO2010123465A2 (fr) * 2009-04-20 2010-10-28 Institut "Jožef Stefan" Procédé pour le traitement d'implants polymères biomédicaux pour l'amélioration de leurs propriétés antithrombogènes

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4326532A (en) 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4613517A (en) 1983-04-27 1986-09-23 Becton, Dickinson And Company Heparinization of plasma treated surfaces
US4521564A (en) 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
US4987181A (en) 1985-07-08 1991-01-22 Battelle Memorial Institute Substrate with an antithromogenic active surface
WO1996008149A1 (fr) 1994-09-16 1996-03-21 Beatrice Haimovich Traitement de surface thromboresistant pour biomateriaux
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
DE19724869A1 (de) 1997-06-12 1998-12-24 Henkel Kgaa Verwendung von Chitosan und/oder Citosanderivaten zur Oberflächenbeschichtung
FR2793693A3 (fr) 1999-05-18 2000-11-24 Martine Bulette Prothese vasculaire impregnee par un biopolymere d'origine vegetale ou bacterienne et procede pour la realisation d'une telle prothese
US7803393B2 (en) 2002-03-08 2010-09-28 Board Of Regents, The University Of Texas System Preparing an implant by gas-plasma treatment of a substrate to couple cells
US20040234575A1 (en) 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
EP1501565A1 (fr) 2002-05-09 2005-02-02 Hemoteq GmbH Composes et procedes pour recouvrir de fa on hemocompatible des surfaces
WO2005053765A1 (fr) 2003-11-27 2005-06-16 Floreane Medical Implants Composition de revetement a base de collagene et de polysaccharides
US20060228391A1 (en) 2004-07-12 2006-10-12 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
WO2010123465A2 (fr) * 2009-04-20 2010-10-28 Institut "Jožef Stefan" Procédé pour le traitement d'implants polymères biomédicaux pour l'amélioration de leurs propriétés antithrombogènes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALENKA VESEL ET AL: "Surface modification of polyester by oxygen- and nitrogen-plasma treatment", SURFACE AND INTERFACE ANALYSIS, vol. 40, no. 11, 10 October 2008 (2008-10-10), pages 1444 - 1453, XP055084372, ISSN: 0142-2421, DOI: 10.1002/sia.2923 *
CHANDY, T.; DAS, G. S.; WILSON, R. F.; RAO, G. H. R., BIOMATERIALS, vol. 21, 2000, pages 699
GOODMAN ET AL.: "Platelet responses to silicon-alloyed pyrolytic carbons", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 83A, 2006, pages 64
KASEMO, B.: "Biological surface science", SURFACE SCIENCE, vol. 500, 2002, pages 656
SHI ET AL.: "Biomaterials and Tissue Engineering", 2004, SPRINGER-VERLAG
TZONEVA-VELINOVA ET AL., JOURNAL OF MATERIAL SCIENCE, vol. 19, 2008, pages 3203
UROS CVELBAR ET AL: "Hemocompatible Poly(ethylene terephthalate) Polymer Modified via Reactive Plasma Treatment", JAPANESE JOURNAL OF APPLIED PHYSICS, vol. 50, no. 8, 1 August 2011 (2011-08-01), pages 08JF02, XP055084367, ISSN: 0021-4922, DOI: 10.1143/JJAP.50.08JF02 *
VESEL A ET AL: "Surface functionalization of organic materials by weakly ionized highly dissociated oxygen plasma", JOURNAL OF PHYSICS: CONFERENCE SERIES, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 162, no. 1, 1 April 2009 (2009-04-01), pages 12015, XP020157453, ISSN: 1742-6596 *
WISSINK, M.J.B.; BEERNINK, R.; POOT, A.A.; ENGBERS, G.H.M.; BEUGELING, T.; VAN AKEN, W.G.; FEIJEN, J.: "Improved endothelialization of vascular grafts by local release of growth factor from heparinized collagen matrices", JOURNAL OF CONTROLLED RELEASE, vol. 64, 2000, pages 103

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