WO2014109658A3 - Aip56 derived peptides - Google Patents

Aip56 derived peptides Download PDF

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Publication number
WO2014109658A3
WO2014109658A3 PCT/PT2014/000001 PT2014000001W WO2014109658A3 WO 2014109658 A3 WO2014109658 A3 WO 2014109658A3 PT 2014000001 W PT2014000001 W PT 2014000001W WO 2014109658 A3 WO2014109658 A3 WO 2014109658A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
aip56
derived peptides
phdp
piscicida
Prior art date
Application number
PCT/PT2014/000001
Other languages
French (fr)
Other versions
WO2014109658A2 (en
Inventor
Nuno Dos Santos
Ana Do Vale
Daniela SILVA
Liliana PEREIRA
Jorge AZEVEDO
Pedro Pereira
Sandra MACEDO-RIBEIRO
Original Assignee
Instituto De Biologia Molecular E Celular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto De Biologia Molecular E Celular filed Critical Instituto De Biologia Molecular E Celular
Publication of WO2014109658A2 publication Critical patent/WO2014109658A2/en
Publication of WO2014109658A3 publication Critical patent/WO2014109658A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides which are able to enter mammalian cells by translocating into the cell cytosol are disclosed, as well as nucleic acids encoding such peptides. Further, peptides for inhibiting NF-kB, and the nucleic acid encoding these peptides are also described. These peptides are based on the toxin AIP56 found in the Gram-negative bacterium Photobacterium damselae piscicida (Phdp).
PCT/PT2014/000001 2013-01-09 2014-01-09 Peptides WO2014109658A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201300381A GB201300381D0 (en) 2013-01-09 2013-01-09 Peptides
GB1300381.9 2013-01-09

Publications (2)

Publication Number Publication Date
WO2014109658A2 WO2014109658A2 (en) 2014-07-17
WO2014109658A3 true WO2014109658A3 (en) 2014-09-18

Family

ID=47748180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2014/000001 WO2014109658A2 (en) 2013-01-09 2014-01-09 Peptides

Country Status (2)

Country Link
GB (1) GB201300381D0 (en)
WO (1) WO2014109658A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014629A2 (en) * 2003-07-29 2005-02-17 Novartis Ag Protein from photobacterium damselae and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014629A2 (en) * 2003-07-29 2005-02-17 Novartis Ag Protein from photobacterium damselae and use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANA DO VALE ET AL: "AIP56, a novel plasmid-encoded virulence factor of Photobacterium damselae subsp. piscicida with apoptogenic activity against sea bass macrophages and neutrophils", MOLECULAR MICROBIOLOGY, vol. 58, no. 4, 1 November 2005 (2005-11-01), pages 1025 - 1038, XP055106980, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.2005.04893.x *
DANIELA S. SILVA ET AL: "The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-[kappa]b P65", PLOS PATHOGENS, vol. 9, no. 2, 28 February 2013 (2013-02-28), US, pages - 12, XP055105799, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1003128 *
M. HOFFMANN ET AL: "Vibrio caribbeanicus sp. nov., isolated from the marine sponge Scleritoderma cyanea", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, vol. 62, no. Pt 8, 19 September 2011 (2011-09-19), pages 1736 - 1743, XP055107063, ISSN: 1466-5026, DOI: 10.1099/ijs.0.032375-0 *
MANUEL T. SILVA ET AL: "AIP56: A Novel Bacterial Apoptogenic Toxin", TOXINS, vol. 2, no. 4, 26 April 2010 (2010-04-26), pages 905 - 918, XP055106810, ISSN: 2072-6651, DOI: 10.3390/toxins2040905 *

Also Published As

Publication number Publication date
WO2014109658A2 (en) 2014-07-17
GB201300381D0 (en) 2013-02-20

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